• Male

J. Heijmans MD

Position: PhD student
Main activities: Research
Specialisation: gastroenterology and hepatology
foto
Focus of research:

Intestinal homeostasis. Translational control in the intestine.

AMC themes: Metabolic disorders and gastrointestinal diseases
Departments: Tytgat Institute for Liver and Intestinal Research
van Lidth de Jeude JF, Meijer BJ, Wielenga MCB , Spaan CN, Baan B, Rosekrans SL, Meisner S, Shen YH, Lee AS, Paton JC, Paton AW, Muncan V, van den Brink GR, Heijmans J, Induction of endoplasmic reticulum stress by deletion of Grp78 depletes Apc mutant intestinal epithelial stem cells. ONCOGENE 2017;36 (24):3397-3405 [PubMed]
Wielenga MCB. Between cancer and therapy: Studies of the colon. S.l.: s.n.; 2016. 153p. ISBN 978-94-6259-973-4 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Heijmans J, Muncan V; copromotor(s): )
Büller NVJA, Rosekrans SL, Metcalfe C, Heijmans J, van Dop WA, Fessler E, Jansen M, Ahn C, Vermeulen JLM, Westendorp BF, Robanus-Maandag EC, Offerhaus GJ, Medema JP, D'Haens GRAM, Wildenberg ME, de Sauvage FJ, Muncan V , van den Brink GR, Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice. GASTROENTEROLOGY 2015;148 (1):170-180.e6 [PubMed]
Rosekrans SL. Homeostasis of the esophageal epithelium: A quest for the stem cell. S.l.: s.n.; 2015. 147p. ISBN 978-94-6259-657-3 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van den Brink GR; copromotor(s): Muncan V, Heijmans J)
Rosekrans SL, Heijmans J, Büller NVJA, Westerlund J , Lee AS, Muncan V , van den Brink GR, ER stress induces epithelial differentiation in the mouse oesophagus. GUT 2015;64 (2):195-202 [PubMed]
van Lidth de Jeude JF, Vermeulen JLM, Montenegro-Miranda PS, van den Brink GR, Heijmans J, A protocol for lentiviral transduction and downstream analysis of intestinal organoids. JOVE-J VIS EXP 2015;2015 (98):e52531 [PubMed]
Wielenga MCB, Colak S, Heijmans J, van Lidth de Jeude JF, Rodermond HM, Paton JC, Paton AW, Vermeulen L, Medema JP, van den Brink GR, ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy. CELL REP 2015;13 (3):490-494 [PubMed]
Amos-Landgraf JM, Heijmans J, Wielenga MCB, Dunkin E, Krentz KJ, Clipson L, Ederveen AG, Groothuis PG, Mosselman S, Muncan V , Hommes DW, Shedlovsky A, Dove WF, van den Brink GR, Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones. P NATL ACAD SCI USA 2014;111 (46):16514-16519 [PubMed]
Heijmans J, Wielenga MCB, Rosekrans SL, van Lidth de Jeude JF, Roelofs J, Groothuis P, Ederveen A, de Jonge-Muller ESM, Biemond I, Hardwick JCH, D'Haens G, Hommes DW, Muncan V , van den Brink GR, Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer. GUT 2014;63 (2):310-316 [PubMed]
Wielenga MCB, van Lidth de Jeude JF, Rosekrans SL, Levin AD, Schukking M, D'Haens GRAM, Heijmans J, Jansen M, Muncan V , van den Brink GR, Azathioprine does not reduce adenoma formation in a mouse model of sporadic intestinal tumorigenesis. WORLD J GASTROENTERO 2014;20 (44):16683-16689 [PubMed]
Heijmans J. A close-up of colon cancer. s.l.: s.n.; 2013. 209p. ISBN 9789090277530 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van den Brink GR, Hommes DW; copromotor(s): Muncan V)
Heijmans J, Büller NVJA, Hoff E, Dihal AA, van der Poll T, van Zoelen MAD, Bierhaus A, Biemond I, Hardwick JCH, Hommes DW, Muncan V, van den Brink GR, Rage signalling promotes intestinal tumourigenesis. ONCOGENE 2013;32 (9):1202-1206 [PubMed]
Heijmans J, van Lidth de Jeude JF, Koo BK, Rosekrans SL, Wielenga MCB, van de Wetering M, Ferrante M, Lee AS, Onderwater JJM, Paton JC, Paton AW, Mommaas AM, Kodach LL, Hardwick JC, Hommes DW, Clevers H, Muncan V , van den Brink GR, ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. CELL REP 2013;3 (4):1128-1139 [PubMed]
Pelczar P, Zibat A, van Dop WA, Heijmans J, Bleckmann A, Gruber W, Nitzki F, Uhmann A, Guijarro MV, Hernando E, Dittmann K, Wienands J, Dressel R, Wojnowski L, Binder C, Taguchi T, Beissbarth T, Hogendoorn PCW, Antonescu CR, Rubin BP, Schulz-Schaeffer W, Aberger F, van den Brink GR, Hahn H, Inactivation of Patched1 in mice leads to development of gastrointestinal stromal-like tumors that express Pdgfrα but not kit. GASTROENTEROLOGY 2013;144 (1):134-144.e6 [PubMed]
Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Göktuna SI, Ziegler PK, Canli O, Heijmans J, Huels DJ, Moreaux G, Rupec RA, Gerhard M, Schmid R, Barker N, Clevers H, Lang R, Neumann J, Kirchner T, Taketo MM, van den Brink GR, Sansom OJ, Arkan MC, Greten FR, Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. CELL 2013;152 (1-2):25-38 [PubMed]
van Dop WA, Rosekrans SL, Uhmann A, Jaks V, Offerhaus GJA, van den Bergh Weerman MA, Kasper M, Heijmans J, Hardwick JCH, Verspaget HW, Hommes DW, Toftgård R, Hahn H, van den Brink GR, Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine oesophagus. GUT 2013;62 (3):348-357 [PubMed]
Baan B , Dihal AA, Hoff E, Bos CL, Voorneveld PW, Koelink PJ, Wildenberg ME, Muncan V , Heijmans J, Verspaget HW, Richel DJ, Hardwick JCH, Hommes DW, Peppelenbosch MP, van den Brink GR, 5-aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer. GUT 2012;61 (12):1708-1715 [PubMed]
Heijmans J, Büller NVJA, Muncan V , van den Brink GR, Rage mediated DAMP signaling in intestinal tumorigenesis. ONCOIMMUNOLOGY 2012;1 (7):1165-1166 [PubMed]
Heijmans J, Büller NV, Muncan V, van den Brink GR, Role of mast cells in colorectal cancer development, the jury is still out. BBA-MOL BASIS DIS 2012;1822 (1):9-13 [PubMed]
Heijmans J, Muncan V , Jacobs RJ, de Jonge-Muller ESM, Graven L, Biemond I, Ederveen AG, Groothuis PG, Mosselman S, Hardwick JC, Hommes DW, van den Brink GR, Intestinal tumorigenesis is not affected by progesterone signaling in rodent models. PLOS ONE 2011;6 (7):e22620 [PubMed]
Muncan V , Heijmans J, Krasinski SD, Büller NV, Wildenberg ME, Meisner S, Radonjic M, Stapleton KA, Lamers WH, Biemond I, van den Bergh Weerman MA, O'Carroll D, Hardwick JC, Hommes DW, van den Brink GR, Blimp1 regulates the transition of neonatal to adult intestinal epithelium. NAT COMMUN 2011;2:452 [PubMed]
Heijmans J, van den Brink GR, Morphogens and the parietal cell: shaping up acid secretion. GASTROENTEROLOGY 2010;139 (6):1830-1833 [PubMed]
Kodach LL, Jacobs RJ, Heijmans J, van Noesel CJM, Langers AMJ, Verspaget HW, Hommes DW, Offerhaus GJA, van den Brink GR, Hardwick JCH, The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer. CARCINOGENESIS 2010;31 (9):1567-1575 [PubMed]
van Dop WA, Heijmans J, Büller NVJA, Snoek SA, Rosekrans SL, Wassenberg EA, van den Bergh Weerman MA, Lanske B, Clarke AR, Winton DJ, Wijgerde M, Offerhaus GJ, Hommes DW, Hardwick JC, de Jonge WJ, Biemond I, van den Brink GR, Loss of Indian Hedgehog activates multiple aspects of a wound healing response in the mouse intestine. GASTROENTEROLOGY 2010;139 (5):1665-76, 1676.e1-10 [PubMed]
van Dop WA, Uhmann A, Wijgerde M, Sleddens-Linkels E, Heijmans J, Offerhaus GJ, van den Bergh Weerman MA, Boeckstaens GE, Hommes DW, Hardwick JC, Hahn H, van den Brink GR, Depletion of the Colonic Epithelial Precursor Cell Compartment Upon Conditional Activation of the Hedgehog Pathway. GASTROENTEROLOGY 2009;136 (7):2195-2203 [PubMed]
de Lorijn F, van Rijn RR, Heijmans J, Reitsma JB, Voskuijl WP, Henneman ODF, Taminiau JA, Benninga MA, The Leech method for diagnosing constipation: intra- and interobserver variability and accuracy. PEDIATR RADIOL 2006;36 (1):43-49 [PubMed]
Voskuijl W, de Lorijn F, Verwijs W, Hogeman P, Heijmans J, Mäkel W, Taminiau J, Benninga M, PEG 3350 (Transipeg) versus lactulose in the treatment of childhood functional constipation: a double blind, randomised, controlled, multicentre trial. GUT 2004;53 (11):1590-1594 [PubMed]
Voskuijl WP, Heijmans J, Heijmans HSA, Taminiau JAJM, Benninga MA, Use of Rome II criteria in childhood defecation disorders: Applicability in clinical and research practice. J PEDIATR-US 2004;145 (2):213-217 [PubMed]
Key publications

Muncan V , Heijmans J, Krasinski SD, Büller NV, Wildenberg ME, Meisner S, Radonjic M, Stapleton KA, Lamers WH, Biemond I, van den Bergh Weerman MA, O'Carroll D, Hardwick JC, Hommes DW, van den Brink GR, Blimp1 regulates the transition of neonatal to adult intestinal epithelium. NAT COMMUN 2011;2:452 [PubMed]
Heijmans J, Muncan V , Jacobs RJ, de Jonge-Muller ESM, Graven L, Biemond I, Ederveen AG, Groothuis PG, Mosselman S, Hardwick JC, Hommes DW, van den Brink GR, Intestinal tumorigenesis is not affected by progesterone signaling in rodent models. PLOS ONE 2011;6 (7):e22620 [PubMed]
van Dop WA, Heijmans J, Büller NVJA, Snoek SA, Rosekrans SL, Wassenberg EA, van den Bergh Weerman MA, Lanske B, Clarke AR, Winton DJ, Wijgerde M, Offerhaus GJ, Hommes DW, Hardwick JC, de Jonge WJ, Biemond I, van den Brink GR, Loss of Indian Hedgehog activates multiple aspects of a wound healing response in the mouse intestine. GASTROENTEROLOGY 2010;139 (5):1665-76, 1676.e1-10 [PubMed]


All Publications

Research programmes
Other research related activities
  • None reported
Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • ZonMw