• Principal Investigator
  • Male

Prof. dr. M.J.A.P. Daemen

Position: Professor
Main activities: Research, Patient care
Specialisation: Cardiovascular Pathology, Atherosclerosis
foto M.J.A.P. Daemen is one of the AMC Principal Investigators
Focus of research:

Atherosclerosis

Plaque (in)stability

Molecular imaging of aherosclerosis

Heart and Brain connections

AMC themes: Cardiovascular Diseases
Departments: Pathology
Bronzwaer ASGT. Maintaining cerebral blood flow: from heart to brain. S.l.: s.n.; 2017. 251p. ISBN 9789492683427 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Daemen MJAP, van Lieshout JJ; copromotor(s): van Osch MJP)
Bronzwaer ASGT, Bogert LWJ, Westerhof BE, Piek JJ, Daemen MJAP, van Lieshout JJ, Abnormal haemodynamic postural response in patients with chronic heart failure. ESC HEART FAIL 2017;4 (2):146-153 [PubMed]
Bronzwaer ASGT, Verbree J, Stok WJ, Daemen MJAP, van Buchem MA, van Osch MJP, van Lieshout JJ, Aging modifies the effect of cardiac output on middle cerebral artery blood flow velocity. PHYSIOL REP 2017;ahead of print [PubMed]
Bronzwaer ASGT, Verbree J, Stok WJ, Daemen MJAP, van Buchem MA, van Osch MJP, van Lieshout JJ, The cerebrovascular response to lower-body negative pressure vs. head-up tilt. J APPL PHYSIOL 2017;122 (4):877-883 [PubMed]
Cai B, Thorp EB, Doran AC, Sansbury BE, Daemen MJAP, Dorweiler B, Spite M, Fredman G, Tabas I, MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis. J CLIN INVEST 2017;127 (2):564-568 [PubMed]
Daugherty A, Tall AR, Daemen MJAP, Falk E, Fisher EA, García-Cardeña G, Lusis AJ, Owens AP 3rd, Rosenfeld ME, Virmani R, Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies A Scientific Statement From the American Heart Association. ARTERIOSCL THROM VAS 2017;37 (9):E131-E157 [PubMed]
Daugherty A, Tall AR, Daemen MJAP, Falk E, Fisher EA, García-Cardeña G, Lusis AJ, Owens AP 3rd, Rosenfeld ME, Virmani R, Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies A Scientific Statement From the American Heart Association. CIRC RES 2017;121 (6):E53-E79 [PubMed]
Hooghiemstra AM, Bertens AS, Leeuwis AE, Bron EE, Bots ML, Brunner-La Rocca HP, de Craen AJM, van der Geest RJ, Greving JP, Kappelle LJ, Niessen WJ, van Oostenbrugge RJ, van Osch MJP, de Roos A, van Rossum AC, Biessels GJ, van Buchem MA, Daemen MJAP, van der Flier WM, The Missing Link in the Pathophysiology of Vascular Cognitive Impairment: Design of the Heart-Brain Study. CEREBROVASC DIS EXTRA 2017;7 (3):140-152 [PubMed]
Mandell DM, Mossa-Basha M, Qiao Y, Hess CP, Hui F, Matouk C, Johnson MH, Daemen MJAP, Vossough A, Edjlali M, Saloner D, Ansari SA, Wasserman BA, Mikulis DJ, Intracranial Vessel Wall MRI: Principles and Expert Consensus Recommendations of the American Society of Neuroradiology. AM J NEURORADIOL 2017;38 (2):218-229 [PubMed]
Stam OCG, Daemen MJAP, van Rijswijk JW, de Mol BAJM, van der Wal AC, Intraleaflet hemorrhages are a common finding in symptomatic aortic and mitral valves. CARDIOVASC PATHOL 2017;30:12-18 [PubMed]
van Hoof RHM, Hermeling E, Sluimer JC, Salzmann J, Hoeks APG, Roussel J, Daemen MJAP, Struijker-Boudier H, Wildberger JE, Heeneman S, Kooi ME, Heart rate lowering treatment leads to a reduction in vulnerable plaque features in atherosclerotic rabbits. PLOS ONE 2017;12 (6):e0179024 [PubMed]
van Hoof RHM, Vöö SA, Sluimer JC, Wijnen NJA, Hermeling E, Schreuder FHBM, Truijman MTB, Cleutjens JPM, Daemen MJAP, Daemen JWH, van Oostenbrugge RJ, Mess WH, Wildberger JE, Heeneman S, Kooi ME, Vessel Wall and Adventitial DCE-MRI Parameters Demonstrate Similar Correlations With Carotid Plaque Microvasculature on Histology. J MAGN RESON IMAGING 2017;46 (4):1053-1059 [PubMed]
Verbree J, Bronzwaer A, van Buchem MA, Daemen M, van Lieshout JJ, van Osch M, Middle cerebral artery diameter changes during rhythmic handgrip exercise in humans. J CEREBR BLOOD F MET 2017;37 (8):2921-2927 [PubMed]
Bink DI. Neuropathological changes in mouse models of cardiovascular diseases. S.l.: s.n.; 2016. 223p. ISBN 978-94-6299-321-1 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Daemen MJAP; copromotor(s): Ritz KA, van der Weerd L)
Bosetti F, Galis ZS, Bynoe MS, Charette M, Cipolla MJ, del Zoppo GJ, Gould D, Hatsukami TS, Jones TLZ, Koenig JI, Lutty GA, Maric-Bilkan C, Stevens T, Tolunay HE, Koroshetz W [Contributors: Agalliu D, Antonetti DA, Boehm M, Brooks CE, Caron KM, Chilian W, Daemen MJ, D'Amato R, Davis TP, Ergul A, Faber JE, Gomez AR, Grayson P, Grumbach I, Grutzendler J, Gu C, Gutterman D, Hallenbeck J, Herman I, Humphrey J, Iadecola C, Inscho EW, Kleinfeld D, Lo EH, Lopez JA, Macknik S, Malik A, Mayadas TN, McGavern D, Meininger GA, Miller VM, Nedergaard M, Nelson MT, Peirce-Cottler S, Ramadan I, Rosenberg GA, Schiffrin EL, Searson P, Stachenfeld N, Stan RV, Suarez Y, Ubogu EE, Vexler ZS, Weyand CM, Zlokovic BV]] , "Small Blood Vessels: Big Health Problems?": Scientific Recommendations of the National Institutes of Health Workshop. J AM HEART ASSOC 2016;5 (11):e004389 [PubMed]
Braster Q, Silvestre Roig C, Hartwig H, Beckers L, den Toom M, Döring Y, Daemen MJ, Lutgens E, Soehnlein O, Inhibition of NET Release Fails to Reduce Adipose Tissue Inflammation in Mice. PLOS ONE 2016;11 (10):e0163922 [PubMed]
Bronzwaer ASGT, Verbree J, Stok WJ, van Buchem MA, Daemen MJAP, van Osch MJP, van Lieshout JJ, Cardiovascular Response Patterns to Sympathetic Stimulation by Central Hypovolemia. FRONT PHYSIOL 2016;7:235 [PubMed]
Daeichin V, Kooiman K, Skachkov I, Bosch JG, Theelen TL, Steiger K, Needles A, Janssen BJ, Daemen MJAP, van der Steen AFW, de Jong N, Sluimer JC, Quantification of Endothelial αvβ3 Expression with High-Frequency Ultrasound and Targeted Microbubbles: In Vitro and In Vivo Studies. ULTRASOUND MED BIOL 2016;42 (9):2283-2293 [PubMed]
Daemen MJ, Ferguson MS, Gijsen FJ, Hippe DS, Kooi ME, Demarco K, van der Wal AC, Yuan C, Hatsukami TS, Carotid plaque fissure: An underestimated source of intraplaque hemorrhage. ATHEROSCLEROSIS 2016;254:102-108 [PubMed]
den Adel B, Daemen MJ, Poelmann RE, van der Weerd L, Molecular Magnetic Resonance Imaging for the Detection of Vulnerable Plaques: Is It Possible?. ARTERIOSCL THROM VAS 2016;ahead of print [PubMed]
Denswil NP, van der Wal AC, Ritz K, de Boer OJ, Aronica E, Troost D, Daemen MJAP, Atherosclerosis in the circle of Willis: Spatial differences in composition and in distribution of plaques. ATHEROSCLEROSIS 2016;251:78-84 [PubMed]
Donners MMPC, Bai L, Lutgens SPM, Wijnands E, Johnson J, Schurgers LJ, Liu CL, Daemen MJAP, Cleutjens KBJM, Shi GP, Biessen EAL, Heeneman S, Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE-/- Mice. PLOS ONE 2016;11 (9):e0162595 [PubMed]
Harteveld AA, Denswil NP, Siero JCW, Zwanenburg JJM, Vink A, Pouran B, Spliet WGM, Klomp DWJ, Luijten PR, Daemen MJ, Hendrikse J, van der Kolk AG, Quantitative Intracranial Atherosclerotic Plaque Characterization at 7T MRI: An Ex Vivo Study with Histologic Validation. AM J NEURORADIOL 2016;37 (5):802-810 [PubMed]
Hartwig H. Neutrophils: emerging role in the immunopathology of atherosclerosis. S.l.: s.n.; 2016. 213p. ISBN 9789462954274 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Daemen MJAP, Lutgens E; copromotor(s): Soehnlein O)
Li X, de Boer OJ, Ploegmaker H, Teeling P, Daemen MJ, de Winter RJ, van der Wal AC, Granulocytes in coronary thrombus evolution after myocardial infarction--time-dependent changes in expression of matrix metalloproteinases. CARDIOVASC PATHOL 2016;25 (1):40-46 [PubMed]
Marsch E. Hypoxia in experimental atherosclerosis: linking cellular oxygen sensors and cholesterol metabolism. S.l.: s.n.; 2016. 249p. ISBN 9789462953642 Proefschrift Maastricht University, CARIM. (Promotor(s): Daemen MJAP, Biessen E; copromotor(s): Sluimer J)
Marsch E, Demandt JAF, Theelen TL, Tullemans BME, Wouters K, Boon MR, van Dijk TH, Gijbels MJ, Dubois LJ, Meex SJR, Mazzone M, Hung G, Fisher EA, Biessen EAL, Daemen MJAP, Rensen PCN, Carmeliet P, Groen AK, Sluimer JC, Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia. EUR HEART J 2016;37 (39):2993-2997 [PubMed]
Marsch E, Theelen TL, Janssen BJA, Briede JJ, Haenen GR, Senden JMG, van Loon LJC, Poeze M, Bierau J, Gijbels MJ, Daemen MJAP, Sluimer JC, The effect of prolonged dietary nitrate supplementation on atherosclerosis development. ATHEROSCLEROSIS 2016;245:212-221 [PubMed]
Theelen TL. The role of hypoxia and vascular growth factors in experimental atherosclerosis. S.l.: s.n.; 2016. 207p. ISBN 9789462954809 Proefschrift Maastricht University, CARIM. (Promotor(s): Daemen MJAP, Biessen EAL; copromotor(s): Sluimer JC)
van der Heiden K, Hoogendoorn A, Daemen MJ, Gijsen FJH, Animal models for plaque rupture: a biomechanical assessment. THROMB HAEMOSTASIS 2016;115 (3):501-508 [PubMed]
Vöö S, Kwee RM, Sluimer JC, Schreuder FHBM, Wierts R, Bauwens M, Heeneman S, Cleutjens JPM, van Oostenbrugge RJ, Daemen JWH, Daemen MJAP, Mottaghy FM, Kooi ME, Imaging Intraplaque Inflammation in Carotid Atherosclerosis With 18F-Fluorocholine Positron Emission Tomography-Computed Tomography: Prospective Study on Vulnerable Atheroma With Immunohistochemical Validation. CIRC-CARDIOVASC IMAG 2016;9 (5):e004467 [PubMed]
Chaudhari SM, Sluimer JC, Koch M, Theelen TL, Manthey HD, Busch M, Caballero-Franco C, Vogel F, Cochain C, Pelisek J, Daemen MJ, Lutz MB, Görlach A, Kissler S, Hermanns HM, Zernecke A, Deficiency of HIF1α in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in Mice. ARTERIOSCL THROM VAS 2015;35 (11):2316-2325 [PubMed]
Daeichin V, Akkus Z, Skachkov I, Kooiman K, Needles A, Sluimer J, Janssen B, Daemen MJAP, van der Steen AFW, de Jong N, Bosch JG, Quantification of bound microbubbles in ultrasound molecular imaging. IEEE T ULTRASON FERR 2015;62 (6):1190-1200 [PubMed]
Daeichin V, Sluimer JC, van der Heiden K, Skachkov I, Kooiman K, Janssen A, Janssen B, Bosch JG, de Jong N, Daemen MJAP, van der Steen AFW, Live Observation of Atherosclerotic Plaque Disruption in Apolipoprotein E-Deficient Mouse. ULTRASOUND INT OPEN 2015;1 (2):E67-E71 [PubMed]
de Rotte AAJ, Truijman MTB, van Dijk AC, Liem MI, Schreuder FHBM, van der Kolk AG, de Kruijk JR, Daemen MJAP, van der Steen AFW, de Borst GJ, Luijten PR, Nederkoorn PJ, Kooi ME, van der Lugt A, Hendrikse J, Plaque Components in Symptomatic Moderately Stenosed Carotid Arteries Related to Cerebral Infarcts The Plaque At RISK Study. STROKE 2015;46 (2):568-571 [PubMed]
Hartwig H, Silvestre Roig C, Daemen M, Lutgens E, Soehnlein O, Neutrophils in atherosclerosis. A brief overview. HAMOSTASEOLOGIE 2015;35 (2):121-127 [PubMed]
Hartwig H, Silvestre-Roig C, Hendrikse J, Beckers L, Paulin N, van der Heiden K, Braster Q, Drechsler M, Daemen MJ, Lutgens E, Soehnlein O, Atherosclerotic Plaque Destabilization in Mice: A Comparative Study. PLOS ONE 2015;10 (10):e0141019 [PubMed]
Herías V, Biessen EAL, Beckers C, Delsing D, Liao M, Daemen MJ, Pham CCTN, Heeneman S, Leukocyte cathepsin C deficiency attenuates atherosclerotic lesion progression by selective tuning of innate and adaptive immune responses. ARTERIOSCL THROM VAS 2015;35 (1):79-86 [PubMed]
Huveneers S, Daemen MJAP, Hordijk PL, Between Rho(k) and a hard place: the relation between vessel wall stiffness, endothelial contractility, and cardiovascular disease. CIRC RES 2015;116 (5):895-908 [PubMed]
Liem MI, Schreuder FHBM, van Dijk AC, de Rotte AAJ, Truijman MTB, Daemen MJAP, van der Steen AFW, Hendrikse J, Nederveen AJ, van der Lugt A, Kooi ME, Nederkoorn PJ, Use of Antiplatelet Agents Is Associated With Intraplaque Hemorrhage on Carotid Magnetic Resonance Imaging: The Plaque at Risk Study. STROKE 2015;46 (12):3411-3415 [PubMed]
Moonen RPM. Quantitative molecular MRI of atherosclerosis. S.l.: s.n.; 2015. 128p. ISBN 978-90-386-3785-3 Proefschrift Technische Universiteit Eindhoven,, -. (Promotor(s): Nicolaij K, Daemen MJAP; copromotor(s): Strijkers GJ)
Moonen RPM, Strijkers GJ, Fayad ZA, Daemen MJAP, Nicolay K. Molecular MR Imaging of Atherosclerosis in: Aikawa E, editor. Cardiovascular Imaging : Arterial and Aortic Valve Inflammation and Calcification. New York: Springer; 2015., p. 269-296
Starmans LWE, Moonen RPM, Aussems-Custers E, Daemen MJAP, Strijkers GJ, Nicolay K, Grüll H, Evaluation of iron oxide nanoparticle micelles for magnetic particle imaging (MPI) of thrombosis. PLOS ONE 2015;10 (3):e0119257 [PubMed]
Theelen TL, Lappalainen JP, Sluimer JC, Gurzeler E, Cleutjens JP, Gijbels MJ, Biessen EAL, Daemen MJAP, Alitalo K, Ylä-Herttuala S, Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice. ATHEROSCLEROSIS 2015;241 (2):297-304 [PubMed]
Thomas AC, Eijgelaar WJ, Daemen MJAP, Newby AC, Foam Cell Formation In Vivo Converts Macrophages to a Pro-Fibrotic Phenotype. PLOS ONE 2015;10 (7):e0128163 [PubMed]
Thomas AC, Eijgelaar WJ, Daemen MJAP, Newby AC, The pro-fibrotic and anti-inflammatory foam cell macrophage paradox. GENOM DATA 2015;6:136-138 [PubMed]
van der Donckt C, Roth L, Vanhoutte G, Blockx I, Bink DI, Ritz K, Pintelon I, Timmermans JP, Bauters D, Martinet W, Daemen MJ, Verhoye M, de Meyer GRY, Fibrillin-1 impairment enhances blood-brain barrier permeability and xanthoma formation in brains of apolipoprotein E-deficient mice. NEUROSCIENCE 2015;295:11-22 [PubMed]
van der Kolk AG, Zwanenburg JJM, Denswil NP, Vink A, Spliet WGM, Daemen MJAP, Visser F, Klomp DWJ, Luijten PR, Hendrikse J, Imaging the intracranial atherosclerotic vessel wall using 7T MRI: initial comparison with histopathology. AM J NEURORADIOL 2015;36 (4):694-701 [PubMed]
van der Valk FM, Sluimer JC, Vöö SA, Verberne HJ, Nederveen AJ, Windhorst AD, Stroes ESG, Lambin P, Daemen MJAP, In Vivo Imaging of Hypoxia in Atherosclerotic Plaques in Humans. JACC-CARDIOVASC IMAG 2015;8 (11):1340-1341 [PubMed]
van Dijk AC, Truijman MTB, Hussain B, Zadi T, Saiedie G, de Rotte AAJ, Liem MI, van der Steen AFW, Daemen MJAP, Koudstaal PJ, Nederkoorn PJ, Hendrikse J, Kooi ME, van der Lugt A, Intraplaque Hemorrhage and the Plaque Surface in Carotid Atherosclerosis: The Plaque At RISK Study (PARISK). AM J NEURORADIOL 2015;36 (11):2127-2133 [PubMed]
van Hinsbergh VWM, Eringa EC, Daemen MJAP, Neovascularization of the atherosclerotic plaque: interplay between atherosclerotic lesion, adventitia-derived microvessels and perivascular fat. CURR OPIN LIPIDOL 2015;26 (5):405-411 [PubMed]
van Hoof RHM, Hermeling E, Truijman MTB, van Oostenbrugge RJ, Daemen JWH, van der Geest RJ, van Orshoven NP, Schreuder AH, Backes WH, Daemen MJAP, Wildberger JE, Kooi ME, Phase-based vascular input function: Improved quantitative DCE-MRI of atherosclerotic plaques. MED PHYS 2015;42 (8):4619-4628 [PubMed]
Eersels K. A novel concept for the specific detection of circulating cells based on heat flow through surface-imprinted polymer layers. s.l.: s.n.; 2014. -p. Proefschrift Universiteit van Hasselt, Geneeskunde. (Promotor(s): Daemen MJ; copromotor(s): )
Gabriels K, Hoving S, Gijbels MJ, Pol JF, te Poele JA, Biessen EA, Daemen MJ, Stewart FA, Heeneman S, Irradiation of existing atherosclerotic lesions increased inflammation by favoring pro-inflammatory macrophages. RADIOTHER ONCOL 2014;110 (3):455-460 [PubMed]
Hanssen NMJ, Wouters K, Huijberts MS, Gijbels MJ, Sluimer JC, Scheijen JLJM, Heeneman S, Biessen EAL, Daemen MJAP, Brownlee M, de Kleijn DP, Stehouwer CDA, Pasterkamp G, Schalkwijk CG, Higher levels of advanced glycation endproducts in human carotid atherosclerotic plaques are associated with a rupture-prone phenotype. EUR HEART J 2014;35 (17):1137-1146 [PubMed]
Hoeksema MA, Gijbels MJJ, van den Bossche J, van der Velden S, Sijm A, Neele AE, Seijkens T, Stöger JL, Meiler S, Boshuizen MCS, Dallinga-Thie GM, Levels JHM, Boon L, Mullican SE, Spann NJ, Cleutjens JP, Glass CK, Lazar MA, de Vries CJM, Biessen EAL, Daemen MJAP, Lutgens E, de Winther MPJ, Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions. EMBO MOL MED 2014;6 (9):1124-1132 [PubMed]
Kwak BR, Bäck M, Bochaton-Piallat ML, Caligiuri G, Daemen MJAP, Davies PF, Hoefer IE, Holvoet P, Jo H, Krams R, Lehoux S, Monaco C, Steffens S, Virmani R, Weber C, Wentzel JJ, Evans PC, Biomechanical factors in atherosclerosis: mechanisms and clinical implications. EUR HEART J 2014;35 (43):3013-20, 3020a-3020d [PubMed]
Marsch E, Theelen TL, Demandt JAF, Jeurissen M, van Gink M, Verjans R, Janssen A, Cleutjens JP, Meex SJR, Donners MM, Haenen GR, Schalkwijk CG, Dubois LJ, Lambin P, Mallat Z, Gijbels MJ, Heemskerk JWM, Fisher EA, Biessen EAL, Janssen BJ, Daemen MJAP, Sluimer JC, Reversal of hypoxia in murine atherosclerosis prevents necrotic core expansion by enhancing efferocytosis. ARTERIOSCL THROM VAS 2014;34 (12):2545-2553 [PubMed]
Ritz K, Denswil NP, Stam OCG, van Lieshout JJ, Daemen MJAP, Cause and mechanisms of intracranial atherosclerosis. CIRCULATION 2014;130 (16):1407-1414 [PubMed]
Schaefer A, te Riet J, Ritz K, Hoogenboezem M, Anthony EC, Mul FPJ, de Vries CJ, Daemen MJ, Figdor CG, van Buul JD, Hordijk PL, Actin-binding proteins differentially regulate endothelial cell stiffness, ICAM-1 function and neutrophil transmigration. J CELL SCI 2014;127 (Part 20):4470-4482 [PubMed]
Silvestre-Roig C, de Winther MP, Weber C, Daemen MJ, Lutgens E, Soehnlein O, Atherosclerotic Plaque Destabilization Mechanisms, Models, and Therapeutic Strategies. CIRC RES 2014;114 (1):214-226 [PubMed]
Steegh FMEG. The role of early peritubular capillary loss in the development of chronic kidney disease. s.l.: s.n.; 2014. 203p. Proefschrift Universiteit Maastricht, FHML. (Promotor(s): Daemen MJAP, van Heurn LWE; copromotor(s): Peutz-Kootstra CJ, Christiaans MHI)
Truijman MTB, de Rotte AAJ, Aaslid R, van Dijk AC, Steinbuch J, Liem MI, Schreuder FHBM, van der Steen AFW, Daemen MJAP, van Oostenbrugge RJ, Wildberger JE, Nederkoorn PJ, Hendrikse J, van der Lugt A, Kooi ME, Mess WH, Intraplaque hemorrhage, fibrous cap status, and microembolic signals in symptomatic patients with mild to moderate carotid artery stenosis: the Plaque at RISK study. STROKE 2014;45 (11):3423-3426 [PubMed]
Truijman MTB, Kooi ME, van Dijk AC, de Rotte AAJ, van der Kolk AG, Liem MI, Schreuder FHBM, Boersma E, Mess WH, van Oostenbrugge RJ, Koudstaal PJ, Kappelle LJ, Nederkoorn PJ, Nederveen AJ, Hendrikse J, van der Steen AFW, Daemen MJAP, van der Lugt A, Plaque At RISK (PARISK): prospective multicenter study to improve diagnosis of high-risk carotid plaques. INT J STROKE 2014;9 (6):747-754 [PubMed]
van Buchem MA, Biessels GJ, Brunner la Rocca HP, de Craen AJM, van der Flier WM, Ikram MA, Kappelle LJ, Koudstaal PJ, Mooijaart SP, Niessen W, van Oostenbrugge R, de Roos A, van Rossum AC, Daemen MJAP, The heart-brain connection: a multidisciplinary approach targeting a missing link in the pathophysiology of vascular cognitive impairment. J ALZHEIMERS DIS 2014;42 (Suppl. 4):S443-S451 [PubMed]
van Geemen D, Smeets MWJ, van Stalborch AMD, Woerdeman LAE, Daemen MJAP, Hordijk PL, Huveneers S, F-actin-anchored focal adhesions distinguish endothelial phenotypes of human arteries and veins. ARTERIOSCL THROM VAS 2014;34 (9):2059-2067 [PubMed]
Verbree J, Bronzwaer ASGT, Ghariq E, Versluis MJ, Daemen MJAP, van Buchem MA, Dahan A, van Lieshout JJ, van Osch MJP, Assessment of middle cerebral artery diameter during hypocapnia and hypercapnia in humans using ultra-high-field MRI. J APPL PHYSIOL 2014;117 (10):1084-1089 [PubMed]
Bink DI, Ritz K, Aronica E, van der Weerd L, Daemen MJAP, Mouse models to study the effect of cardiovascular risk factors on brain structure and cognition. J CEREBR BLOOD F MET 2013;33 (11):1666-1684 [PubMed]
Borissoff JI, Otten JJT, Heeneman S, Leenders P, van Oerle R, Soehnlein O, Loubele STBG, Hamulyák K, Hackeng TM, Daemen MJAP, Degen JL, Weiler H, Esmon CT, van Ryn J, Biessen EAL, Spronk HMH, ten Cate H, Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner. PLOS ONE 2013;8 (2):e55784 [PubMed]
Christ A. Dendritic cells in hyperlipdemia-associated atherosclerosis. s.l.: s.n.; 2013. -p. Proefschrift Maastricht Universitty, Medicine. (Promotor(s): Daemen MJ; copromotor(s): )
Christ A, Temmerman L, Legein B, Daemen MJAP, Biessen EAL, Dendritic cells in cardiovascular diseases: epiphenomenon, contributor, or therapeutic opportunity. CIRCULATION 2013;128 (24):2603-2613 [PubMed]
Daemen MJAP, The heart and the brain: an intimate and underestimated relation. NETH HEART J 2013;21 (2):53-54 [PubMed]
de Boer OJ, Li X, Teeling P, Mackaay C, Ploegmakers HJ, van der Loos CM, Daemen MJ, de Winter RJ, van der Wal AC, Neutrophils, neutrophil extracellular traps and interleukin-17 associate with the organisation of thrombi in acute myocardial infarction. THROMB HAEMOSTASIS 2013;109 (2):290-297 [PubMed]
Eersels K, van Grinsven B, Ethirajan A, Timmermans S, Jiménez Monroy KL, Bogie JFJ, Punniyakoti S, Vandenryt T, Hendriks JJA, Cleij TJ, Daemen MJAP, Somers V, de Ceuninck W, Wagner P, Selective identification of macrophages and cancer cells based on thermal transport through surface-imprinted polymer layers. ACS APPL MATER INTER 2013;5 (15):7258-7267 [PubMed]
Gabriels K. Cardiovascular Disease: Role of Immunosuppression and Radiotherapy. s.l.: s.n.; 2013. -p. Proefschrift Universiteit Maastricht, Gezondheidswetenschappen. (Promotor(s): Daemen MJAP; copromotor(s): )
Gaens ME, Backes WH, Rozel S, Lipperts M, Sanders SN, Jaspers K, Cleutjens JPM, Sluimer JC, Heeneman S, Daemen MJAP, Welten RJTJ, Daemen JWH, Wildberger JE, Kwee RM, Kooi ME, Dynamic contrast-enhanced MR imaging of carotid atherosclerotic plaque: model selection, reproducibility, and validation. RADIOLOGY 2013;266 (1):271-279 [PubMed]
Hoefer IE, den Adel B, Daemen MJAP, Biomechanical factors as triggers of vascular growth. CARDIOVASC RES 2013;99 (2):276-283 [PubMed]
Hoefer IE, Sels JW, Jukema JW, Bergheanu S, Biessen E, McClellan E, Daemen M, Doevendans P, de Groot P, Hillaert M, Horsman S, Ilhan M, Kuiper J, Pijls N, Redekop K, van der Spek P, Stubbs A, van de Veer E, Waltenberger J, van Zonneveld AJ, Pasterkamp G, Circulating cells as predictors of secondary manifestations of cardiovascular disease: design of the CIRCULATING CELLS study. CLIN RES CARDIOL 2013;102 (11):847-856 [PubMed]
Lievens D, Habets KL, Robertson AK, Laouar Y, Winkels H, Rademakers T, Beckers L, Wijnands E, Boon L, Mosaheb M, Ait-Oufella H, Mallat Z, Flavell RA, Rudling M, Binder CJ, Gerdes N, Biessen EAL, Weber C, Daemen MJAP, Kuiper J, Lutgens E, Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis. EUR HEART J 2013;34 (48):3717-3727 [PubMed]
Marsch E, Sluimer JC, Daemen MJAP, Hypoxia in atherosclerosis and inflammation. CURR OPIN LIPIDOL 2013;24 (5):393-400 [PubMed]
Rademakers T, Douma K, Hackeng TM, Post MJ, Sluimer JC, Daemen MJAP, Biessen EAL, Heeneman S, van Zandvoort MAMJ, Plaque-associated vasa vasorum in aged apolipoprotein E-deficient mice exhibit proatherogenic functional features in vivo. ARTERIOSCL THROM VAS 2013;33 (2):249-256 [PubMed]
Ritz K, van Buchem MA, Daemen MJ, The heart-brain connection: mechanistic insights and models. NETH HEART J 2013;21 (2):55-57 [PubMed]
Starmans LWE, van Duijnhoven SMJ, Rossin R, Aime S, Daemen MJAP, Nicolay K, Grüll H, SPECT imaging of fibrin using fibrin-binding peptides. CONTRAST MEDIA MOL I 2013;8 (3):229-237 [PubMed]
Starmans LWE, van Duijnhoven SMJ, Rossin R, Berben M, Aime S, Daemen MJAP, Nicolay K, Grüll H, Evaluation of 111In-labeled EPep and FibPep as tracers for fibrin SPECT imaging. MOL PHARMACEUT 2013;10 (11):4309-4321 [PubMed]
Truijman MTB, Kwee RM, van Hoof RHM, Hermeling E, van Oostenbrugge RJ, Mess WH, Backes WH, Daemen MJ, Bucerius J, Wildberger JE, Kooi ME, Combined 18F-FDG PET-CT and DCE-MRI to assess inflammation and microvascularization in atherosclerotic plaques. STROKE 2013;44 (12):3568-3570 [PubMed]
Versteylen MO, Kietselaer BL, Dagnelie PC, Joosen IA, Dedic A, Raaijmakers RH, Wildberger JE, Nieman K, Crijns HJ, Niessen WJ, Daemen MJ, Hofstra L, Additive value of semiautomated quantification of coronary artery disease using cardiac computed tomographic angiography to predict future acute coronary syndrome. J AM COLL CARDIOL 2013;61 (22):2296-2305 [PubMed]
Ylä-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jauhiainen S, Jukema JW, Krams R, Kwak BR, Marx N, Naruszewicz M, Newby A, Pasterkamp G, Serruys PWJC, Waltenberger J, Weber C, Tokgözoglu L, Stabilization of atherosclerotic plaques: an update. EUR HEART J 2013;34 (42):3251-3258 [PubMed]
Döring Y, Manthey HD, Drechsler M, Lievens D, Megens RTA, Soehnlein O, Busch M, Manca M, Koenen RR, Pelisek J, Daemen MJ, Lutgens E, Zenke M, Binder CJ, Weber C, Zernecke A, Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis. CIRCULATION 2012;125 (13):1673-1683 [PubMed]
Gabriels K, Hoving S, Seemann I, Visser NL, Gijbels MJ, Pol JF, Daemen MJ, Stewart FA, Heeneman S, Local heart irradiation of ApoE(-/-) mice induces microvascular and endocardial damage and accelerates coronary atherosclerosis. RADIOTHER ONCOL 2012;105 (3):358-364 [PubMed]
Hoving S, Heeneman S, Gijbels MJJ, te Poele JAM, Visser N, Cleutjens J, Russell NS, Daemen MJAP, Stewart FA, Irradiation induces different inflammatory and thrombotic responses in carotid arteries of wildtype C57BL/6J and atherosclerosis-prone ApoE(-/-) mice. RADIOTHER ONCOL 2012;105 (3):365-370 [PubMed]
Stadler N, Heeneman S, Vöö S, Stanley N, Giles GI, Gang BP, Croft KD, Mori TA, Vacata V, Daemen MJAP, Waltenberger J, Davies MJ, Reduced metal ion concentrations in atherosclerotic plaques from subjects with Type 2 diabetes mellitus. ATHEROSCLEROSIS 2012;222 (2):512-518 [PubMed]
Stöger JL, Gijbels MJJ, van der Velden S, Manca M, van der Loos CM, Biessen EAL, Daemen MJAP, Lutgens E, de Winther MPJ, Distribution of macrophage polarization markers in human atherosclerosis. ATHEROSCLEROSIS 2012;225 (2):461-468 [PubMed]
Daissormont ITMN, Christ A, Temmerman L, Sampedro Millares S, Seijkens T, Rousch M, Poggi M, Boon L, van der Loos C, Daemen M, Lutgens E, Halvorsen B, Aukrust P, Janssen E, Biessen EAL, Plasmacytoid Dendritic Cells Protect Against Atherosclerosis by Tuning T-Cell Proliferation and Activity. CIRC RES 2011;109 (12):1387-1395 [PubMed]
Engel D, Beckers L, Wijnands E, Seijkens T, Lievens D, Drechsler M, Gerdes N, Soehnlein O, Daemen MJAP, Stan RV, Biessen EAL, Lutgens E, Caveolin-1 deficiency decreases atherosclerosis by hampering leukocyte influx into the arterial wall and generating a regulatory T-cell response. FASEB J 2011;25 (11):3838-3848 [PubMed]
Hoving S, Heeneman S, Gijbels MJJ, te Poele JAM, Pol JFC, Gabriels K, Russell NS, Daemen MJAP, Stewart FA, Anti-inflammatory and anti-thrombotic intervention strategies using atorvastatin, clopidogrel and knock-down of CD40L do not modify radiation-induced atherosclerosis in ApoE null mice. RADIOTHER ONCOL 2011;101 (1):100-108 [PubMed]
Steegh FMEG, Gelens MACJ, Nieman FHM, van Hooff JP, Cleutjens JPM, van Suylen RJ, Daemen MJAP, van Heurn ELW, Christiaans MHL, Peutz-Kootstra CJ, Early loss of peritubular capillaries after kidney transplantation. J AM SOC NEPHROL 2011;22 (6):1024-1029 [PubMed]
Ylä-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jukema JW, Krams R, Kwak BR, Marx N, Naruszewicz M, Newby A, Pasterkamp G, Serruys PWJC, Waltenberger J, Weber C, Tokgözoglu L, Stabilisation of atherosclerotic plaques. Position paper of the European Society of Cardiology (ESC) Working Group on atherosclerosis and vascular biology. THROMB HAEMOSTASIS 2011;106 (1):1-19 [PubMed]
Bai L. Immunosuppressive and anti-proteolytic therapy in vascular diseases. Maastricht: Printservice TU/e; 2010. 174p. ISBN 9789090251462 Proefschrift Universiteit Maastricht, Pathologie. (Promotor(s): Biessen EAL, Daemen MJAP; copromotor(s): Heeneman S)
Bai L, Beckers L, Wijnands E, Lutgens SPM, Herías MV, Saftig P, Daemen MJAP, Cleutjens K, Lutgens E, Biessen EAL, Heeneman S, Cathepsin K gene disruption does not affect murine aneurysm formation. ATHEROSCLEROSIS 2010;209 (1):96-103 [PubMed]
Bai L, Gabriels K, Wijnands E, Rousch M, Daemen MJAP, Tervaert JWC, Biessen EAL, Heeneman S, Low- but not high-dose FK506 treatment confers atheroprotection due to alternative macrophage activation and unaffected cholesterol levels. THROMB HAEMOSTASIS 2010;104 (1):143-150 [PubMed]
Borissoff JI, Heeneman S, Kilinç E, Kassák P, van Oerle R, Winckers K, Govers-Riemslag JWP, Hamulyák K, Hackeng TM, Daemen MJAP, ten Cate H, Spronk HMH, Early atherosclerosis exhibits an enhanced procoagulant state. CIRCULATION 2010;122 (8):821-830 [PubMed]
de kleijn DPV, Moll FL, Hellings WE, Ozsarlak-Sozer G, de Bruin P, Doevendans PA, Vink A, Catanzariti LM, Schoneveld AH, Algra A, Daemen MJ, Biessen EA, de Jager W, Zhang H, de Vries JP, Falk E, Lim SK, van der Spek PJ, Sze SK, Pasterkamp G, Local atherosclerotic plaques are a source of prognostic biomarkers for adverse cardiovascular events. ARTERIOSCL THROM VAS 2010;30 (3):612-619 [PubMed]
Eijgelaar WJ, Horrevoets AJG, Bijnens APJJ, Daemen MJAP, Verhaegh WFJ, Equivalence testing in microarray analysis: similarities in the transcriptome of human atherosclerotic and nonatherosclerotic macrophages. PHYSIOL GENOMICS 2010;41 (3):212-223 [PubMed]
Goossens P, Gijbels MJJ, Zernecke A, Eijgelaar W, Vergouwe MN, van der Made I, Vanderlocht J, Beckers L, Buurman WA, Daemen MJAP, Kalinke U, Weber C, Lutgens E, de Winther MPJ, Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions. CELL METAB 2010;12 (2):142-153 [PubMed]
Hoving S, Heeneman S, Gijbels MJJ, te Poele JAM, Bolla M, Pol JFC, Simons MY, Russell NS, Daemen MJ, Stewart FA, NO-donating aspirin and aspirin partially inhibit age-related atherosclerosis but not radiation-induced atherosclerosis in ApoE null mice. PLOS ONE 2010;5 (9):e12874 [PubMed]
Lievens D. Cell-type specific CD40-CD40L interactions in atherosclerosis. Maastricht: Die Keure, Bruges, Belgium; 2010. 215p. ISBN 9789090250120 Proefschrift Universiteit Maastricht, Pathologie. (Promotor(s): Biessen EA, Daemen MJAP; copromotor(s): Lutgens E)
Lievens D, Zernecke A, Seijkens T, Soehnlein O, Beckers L, Munnix ICA, Wijnands E, Goossens P, van Kruchten R, Thevissen L, Boon L, Flavell RA, Noelle RJ, Gerdes N, Biessen EA, Daemen MJAP, Heemskerk JWM, Weber C, Lutgens E, Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis. BLOOD 2010;116 (20):4317-4327 [PubMed]
Lobbes MBI, Heeneman S, Passos VL, Welten R, Kwee RM, van der Geest RJ, Wiethoff AJ, Caravan P, Misselwitz B, Daemen MJAP, van Engelshoven JMA, Leiner T, Kooi ME, Gadofosveset-enhanced magnetic resonance imaging of human carotid atherosclerotic plaques: a proof-of-concept study. INVEST RADIOL 2010;45 (5):275-281 [PubMed]
Lobbes MBI, Kooi ME, Lutgens E, Ruiters AW, Lima Passos V, Braat SHJG, Rousch M, ten Cate H, van Engelshoven JMA, Daemen MJAP, Heeneman S, Leukocyte counts, myeloperoxidase, and pregnancy-associated plasma protein a as biomarkers for cardiovascular disease: towards a multi-biomarker approach. INT J VASC MED 2010;2010:726207 [PubMed]
Lutgens E, Lievens D, Beckers L, Wijnands E, Soehnlein O, Zernecke A, Seijkens T, Engel D, Cleutjens J, Keller AM, Naik SH, Boon L, Oufella HA, Mallat Z, Ahonen CL, Noelle RJ, de Winther MP, Daemen MJ, Biessen EA, Weber C, Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile. J EXP MED 2010;207 (2):391-404 [PubMed]
Miserus RJJHM. Molecular Imaging of Atherosclerosis and Thrombus Formation. Maastricht: Universitaire Pers Maastricht; 2010. 160p. ISBN 9789052788906 Proefschrift Universiteit Maastricht, Pathologie. (Promotor(s): Daemen MJAP, van Engelshoven JMA; copromotor(s): Kooi ME, Heeneman S)
Muntendam P, McCall C, Sanz J, Falk E, Fuster V [Contributors: Fuster V, Falk E, Badimon JJ, Botnar RM, Daemen MJAP, Fayad ZA, Garcia M, Ginsburg GS, Hazen SL, King SB, Moreno PR, Nordestgaard BG, Rudd JHF, Shah PK, Sillesen H, van der Steen AFW, Yacoub MH, Yuan C, Bui JT, Chen CJ, Seow A, Muntendam P, Plump A, Raichlen J, Smit P, Stolzenbach JC, Urquhart R]] , The BioImage Study: novel approaches to risk assessment in the primary prevention of atherosclerotic cardiovascular disease--study design and objectives. AM HEART J 2010;160 (1):49-57.e1 [PubMed]
ten Kate GL, Sijbrands EJG, Valkema R, ten Cate FJ, Feinstein SB, van der Steen AFW, Daemen MJAP, Schinkel AFL, Molecular imaging of inflammation and intraplaque vasa vasorum: a step forward to identification of vulnerable plaques?. J NUCL CARDIOL 2010;17 (5):897-912 [PubMed]
Daemen MJ, Kooi ME, Intraplaque hemorrhage as a stimulator of episodic growth of advanced, but nonsymptomatic atherosclerotic lesions bridging the gap. JACC-CARDIOVASC IMAG 2009;2 (12):1390-1392 [PubMed]
Eijgelaar WJ, Heeneman S, Daemen MJAP, The vulnerable patient: refocusing on the plaque?. THROMB HAEMOSTASIS 2009;102 (2):231-239 [PubMed]
Lievens D, Eijgelaar WJ, Biessen EAL, Daemen MJAP, Lutgens E, The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. THROMB HAEMOSTASIS 2009;102 (2):206-214 [PubMed]
Lobbes M. Non-invasive assessment of cardiovascular disease A study of atherosclerotic lesions using biomarkers and MRI. Maastricht: Universitaire Pers Maastricht; 2009. 156p. ISBN 9789052788340 Proefschrift Universiteit Maastricht, Pathologie. (Promotor(s): van Engelshoven JMA, Daemen MJAP; copromotor(s): Kooi ME, Heeneman S)
Lobbes MBI, Miserus RJJHM, Heeneman S, Passos VL, Mutsaers PHA, Debernardi N, Misselwitz B, Post M, Daemen MJAP, van Engelshoven JMA, Leiner T, Kooi ME, Atherosclerosis: contrast-enhanced MR imaging of vessel wall in rabbit model--comparison of gadofosveset and gadopentetate dimeglumine. RADIOLOGY 2009;250 (3):682-691 [PubMed]
Miserus RJJHM, Herías MV, Prinzen L, Lobbes MBI, van Suylen RJ, Dirksen A, Hackeng TM, Heemskerk JWM, van Engelshoven JMA, Daemen MJAP, van Zandvoort MAMJ, Heeneman S, Kooi ME, Molecular MRI of early thrombus formation using a bimodal alpha2-antiplasmin-based contrast agent. JACC-CARDIOVASC IMAG 2009;2 (8):987-996 [PubMed]
Plasschaert H, Heeneman S, Daemen MJ, Progression in atherosclerosis: histological features and pathophysiology of atherosclerotic lesions. TOP MAGN RESON IMAGING 2009;20 (4):227-237 [PubMed]
Russell NS, Hoving S, Heeneman S, Hage JJ, Woerdeman LAE, de Bree R, Lohuis PJFM, Smeele L, Cleutjens J, Valenkamp A, Dorresteijn LDA, Dalesio O, Daemen MJ, Stewart FA, Novel insights into pathological changes in muscular arteries of radiotherapy patients. RADIOTHER ONCOL 2009;92 (3):477-483 [PubMed]
Schapira K, Burkly LC, Zheng TS, Wu P, Groeneweg M, Rousch M, Kockx MM, Daemen MJAP, Heeneman S, Fn14-Fc fusion protein regulates atherosclerosis in ApoE-/- mice and inhibits macrophage lipid uptake in vitro. ARTERIOSCL THROM VAS 2009;29 (12):2021-2027 [PubMed]
Sluimer JC, Daemen MJ, Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis. J PATHOL 2009;218 (1):7-29 [PubMed]
Sluimer JC, Daemen MJAP, Nieuwe inzichten in het ontstaan van atherosclerose--angiogenese en hypoxie spelen een cruciale rol. NED TIJDSCHR GENEESKD 2009;153:A847 [PubMed]
Sluimer JC, Kolodgie FD, Bijnens APJJ, Maxfield K, Pacheco E, Kutys B, Duimel H, Frederik PM, van Hinsbergh VWM, Virmani R, Daemen MJAP, Thin-walled microvessels in human coronary atherosclerotic plaques show incomplete endothelial junctions relevance of compromised structural integrity for intraplaque microvascular leakage. J AM COLL CARDIOL 2009;53 (17):1517-1527 [PubMed]
van den Borne SWM. Myocardial Infarct Healing Rupture and Remodeling. Maastricht: Universitaire Pers Maastricht; 2009. 185p. ISBN 9789052788173 Proefschrift Universiteit Maastricht, Pathologie. (Promotor(s): Smits JFM, Daemen MJAP; copromotor(s): Blankesteijn WM)
van den Borne SWM, Cleutjens JPM, Hanemaaijer R, Creemers EE, Smits JFM, Daemen MJAP, Blankesteijn WM, Increased matrix metalloproteinase-8 and -9 activity in patients with infarct rupture after myocardial infarction. CARDIOVASC PATHOL 2009;18 (1):37-43 [PubMed]
van den Borne SWM, Isobe S, Zandbergen HR, Li P, Petrov A, Wong ND, Fujimoto S, Fujimoto A, Lovhaug D, Smits JFM, Daemen MJAP, Blankesteijn WM, Reutelingsperger C, Zannad F, Narula N, Vannan MA, Pitt B, Hofstra L, Narula J, Molecular imaging for efficacy of pharmacologic intervention in myocardial remodeling. JACC-CARDIOVASC IMAG 2009;2 (2):187-198 [PubMed]
van den Borne SWM, van de Schans VAM, Strzelecka AE, Vervoort-Peters HTM, Lijnen PM, Cleutjens JPM, Smits JFM, Daemen MJAP, Janssen BJA, Blankesteijn WM, Mouse strain determines the outcome of wound healing after myocardial infarction. CARDIOVASC RES 2009;84 (2):273-282 [PubMed]
Cappendijk VC, Heeneman S, Kessels AGH, Cleutjens KBJM, Schurink GWH, Welten RJTJ, Mess WH, van Suylen RJ, Leiner T, Daemen MJAP, van Engelshoven JMA, Kooi ME, Comparison of single-sequence T1w TFE MRI with multisequence MRI for the quantification of lipid-rich necrotic core in atherosclerotic plaque. J MAGN RESON IMAGING 2008;27 (6):1347-1355 [PubMed]
Cappendijk VC, Kessels AGH, Heeneman S, Cleutjens KBJM, Schurink GWH, Welten RJTJ, Mess WH, van Suylen RJ, Leiner T, Daemen MJAP, van Engelshoven JMA, Kooi ME, Comparison of lipid-rich necrotic core size in symptomatic and asymptomatic carotid atherosclerotic plaque: Initial results. J MAGN RESON IMAGING 2008;27 (6):1356-1361 [PubMed]
Cleutjens KBJM, Faber BCG, Rousch M, van Doorn R, Hackeng TM, Vink C, Geusens P, ten Cate H, Waltenberger J, Tchaikovski V, Lobbes M, Somers V, Sijbers A, Black D, Kitslaar PJEHM, Daemen MJAP, Noninvasive diagnosis of ruptured peripheral atherosclerotic lesions and myocardial infarction by antibody profiling. J CLIN INVEST 2008;118 (8):2979-2985 [PubMed]
Daemen MJAP, Does atherosclerotic plaque histology predict the risk of restenosis after carotid endarterectomy?. NAT CLIN PRACT CARD 2008;5 (8):436-437 [PubMed]
Donners MMPC, Beckers L, Lievens D, Munnix I, Heemskerk J, Janssen BJ, Wijnands E, Cleutjens J, Zernecke A, Weber C, Ahonen CL, Benbow U, Newby AC, Noelle RJ, Daemen MJAP, Lutgens E, The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling. BLOOD 2008;111 (9):4596-4604 [PubMed]
Heeneman S, Lutgens E, Schapira KB, Daemen MJAP, Biessen EAL, Control of atherosclerotic plaque vulnerability: insights from transgenic mice. FRONT BIOSCI 2008;13:6289-6313 [PubMed]
Hoving S, Heeneman S, Gijbels MJJ, te Poele JAM, Russell NS, Daemen MJAP, Stewart FA, Single-dose and fractionated irradiation promote initiation and progression of atherosclerosis and induce an inflammatory plaque phenotype in ApoE(-/-) mice. INT J RADIAT ONCOL 2008;71 (3):848-857 [PubMed]
Hurks R, Hoefer IE, de Kleijn DP, Daemen MJ, Moll FL, Pasterkamp G, Past, current and future concepts in atherosclerotic biobanking. FUTURE CARDIOL 2008;4 (6):639-649 [PubMed]
Kisters N. Heterogeneity in human atherosclerotic gene expression profiles From man to macrophages. Maastricht: Ponsen & Looijen; 2008. 219p. ISBN 9789064642968 Proefschrift Universiteit Maastricht, Pathologie. (Promotor(s): Daemen MJAP; copromotor(s): Cleutjens KBJM)
Lutgens E, Tjwa M, Garcia de Frutos P, Wijnands E, Beckers L, Dahlbäck B, Daemen MJAP, Carmeliet P, Moons L, Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis. J PATHOL 2008;216 (1):55-63 [PubMed]
Pasterkamp G, Daemen M, Circulating cells: the biofactory for markers of atherosclerotic disease. EUR HEART J 2008;29 (22):2701-2702 [PubMed]
Sluimer JC. Hypoxia, HIF and angiogenesis in atherosclerosis. Maastricht: Universitaire Pers Maastricht; 2008. 218p. ISBN 9789052787169 Proefschrift Universiteit Maastricht, Pathologie. (Promotor(s): Daemen MJAP; copromotor(s): Bijnens APJJ)
Sluimer JC, Gasc JM, Hamming I, van Goor H, Michaud A, van den Akker LH, Jütten B, Cleutjens J, Bijnens APJJ, Corvol P, Daemen MJAP, Heeneman S, Angiotensin-converting enzyme 2 (ACE2) expression and activity in human carotid atherosclerotic lesions. J PATHOL 2008;215 (3):273-279 [PubMed]
Sluimer JC, Gasc JM, van Wanroij JL, Kisters N, Groeneweg M, Sollewijn Gelpke MD, Cleutjens JP, van den Akker LH, Corvol P, Wouters BG, Daemen MJ, Bijnens APJ, Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis. J AM COLL CARDIOL 2008;51 (13):1258-1265 [PubMed]
Smook MLF, van Leeuwen M, Heeringa P, Damoiseaux JGMC, Theunissen R, Daemen MJAP, Lutgens E, Tervaert JWC, Anti-oxLDL antibody isotype levels, as potential markers for progressive atherosclerosis in APOE and APOECD40L mice. CLIN EXP IMMUNOL 2008;154 (2):264-269 [PubMed]
Stadler N, Stanley N, Heeneman S, Vacata V, Daemen MJAP, Bannon PG, Waltenberger J, Davies MJ, Accumulation of zinc in human atherosclerotic lesions correlates with calcium levels but does not protect against protein oxidation. ARTERIOSCL THROM VAS 2008;28 (5):1024-1030 [PubMed]
Tjwa M, Bellido-Martin L, Lin Y, Lutgens E, Plaisance S, Bono F, Delesque-Touchard N, Hervé C, Moura R, Billiau AD, Aparicio C, Levi M, Daemen M, Dewerchin M, Lupu F, Arnout J, Herbert JM, Waer M, García de Frutos P, Dahlbäck B, Carmeliet P, Hoylaerts MF, Moons L, Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes. BLOOD 2008;111 (8):4096-4105 [PubMed]
van den Borne SWM, Isobe S, Verjans JW, Petrov A, Lovhaug D, Li P, Zandbergen HR, Ni Y, Frederik P, Zhou J, Arbo B, Rogstad A, Cuthbertson A, Chettibi S, Reutelingsperger C, Blankesteijn WM, Smits JFM, Daemen MJAP, Zannad F, Vannan MA, Narula N, Pitt B, Hofstra L, Narula J, Molecular imaging of interstitial alterations in remodeling myocardium after myocardial infarction. J AM COLL CARDIOL 2008;52 (24):2017-2028 [PubMed]
van den Borne SWM, Narula J, Voncken JW, Lijnen PM, Vervoort-Peters HTM, Dahlmans VEH, Smits JFM, Daemen MJAP, Blankesteijn WM, Defective intercellular adhesion complex in myocardium predisposes to infarct rupture in humans. J AM COLL CARDIOL 2008;51 (22):2184-2192 [PubMed]
Ait-Oufella H, Kinugawa K, Zoll J, Simon T, Boddaert J, Heeneman S, Blanc-Brude O, Barateau V, Potteaux S, Merval R, Esposito B, Teissier E, Daemen MJ, Lesèche G, Boulanger C, Tedgui A, Mallat Z, Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice. CIRCULATION 2007;115 (16):2168-2177 [PubMed]
Beckers L, Heeneman S, Wang L, Burkly LC, Rousch MMJ, Davidson NO, Gijbels MJJ, de Winther MPJ, Daemen MJAP, Lutgens E, Disruption of hedgehog signalling in ApoE - /- mice reduces plasma lipid levels, but increases atherosclerosis due to enhanced lipid uptake by macrophages. J PATHOL 2007;212 (4):420-428 [PubMed]
Blanc-Brude OP, Teissier E, Castier Y, Lesèche G, Bijnens AP, Daemen M, Staels B, Mallat Z, Tedgui A, IAP survivin regulates atherosclerotic macrophage survival. ARTERIOSCL THROM VAS 2007;27 (4):901-907 [PubMed]
Fledderus JO, van Thienen JV, Boon RA, Dekker RJ, Rohlena J, Volger OL, Bijnens APJJ, Daemen MJAP, Kuiper J, van Berkel TJC, Pannekoek H, Horrevoets AJG, Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2. BLOOD 2007;109 (10):4249-4257 [PubMed]
Heeneman S, Daemen MJAP, Cardiovascular risks in spondyloarthritides. CURR OPIN RHEUMATOL 2007;19 (4):358-362 [PubMed]
Heeneman S, Donners MMPC, Bai L, Daemen MJAP, Drug-induced immunomodulation to affect the development and progression of atherosclerosis: a new opportunity?. EXPERT REV CARDIOVASC THER 2007;5 (2):345-364 [PubMed]
Heeneman S, Sluimer JC, Daemen MJAP, Angiotensin-converting enzyme and vascular remodeling. CIRC RES 2007;101 (5):441-454 [PubMed]
Knaapen AM, Curfs DM, Pachen DM, Gottschalk RW, de Winther MPJ, Daemen MJ, van Schooten FJ, The environmental carcinogen benzo[a]pyrene induces expression of monocyte-chemoattractant protein-1 in vascular tissue: a possible role in atherogenesis. MUTAT RES-FUND MOL M 2007;621 (1-2):31-41 [PubMed]
Lutgens E, Lievens D, Beckers L, Donners M, Daemen M, CD40 and its ligand in atherosclerosis. TRENDS CARDIOVAS MED 2007;17 (4):118-123 [PubMed]
Lutgens SPM. Functional genomics in atherosclerosis: focus on cathepsin K. Maastricht: Universitaire Pers Maastricht; 2007. 160p. ISBN 9789052786537 Proefschrift Universiteit Maastricht, Pathologie. (Promotor(s): Daemen MJAP; copromotor(s): Cleutjens KBJM, Heeneman S)
Lutgens SPM, Cleutjens KBJM, Daemen MJAP, Heeneman S, Cathepsin cysteine proteases in cardiovascular disease. FASEB J 2007;21 (12):3029-3041 [PubMed]
Moreira W. Atrial Flutter / Atrial Fibrillation Long term folluw-up of cryoablation with new pathophysiologic insights. Maastricht: Universitaire Pers Maastricht; 2007. 184p. Proefschrift Universiteit Maastricht, Pathologie. (Promotor(s): Daemen MJAP; copromotor(s): Rodriguez LM, Timmermans CCMM)
Pasterkamp G, Daemen M, Stabilizing the vulnerable plaque: the search for the magic bullet. CURR PHARM DESIGN 2007;13 (10):979-982 [PubMed]
Schapira K. Atherosclerotic plaque stability: identification and validation of key regulators. Maastricht: Universitaire Pers Maastricht; 2007. 151p. ISBN 9789052786445 Proefschrift Universiteit Maastricht, Pathologie. (Promotor(s): Daemen MJAP; copromotor(s): Heeneman S)
Schapira K, Heeneman S, Daemen MJAP, Animal models to study plaque vulnerability. CURR PHARM DESIGN 2007;13 (10):1013-1020 [PubMed]
Sluimer JC, Kisters N, Cleutjens KB, Volger OL, Horrevoets AJ, van den Akker LH, Bijnens APJ, Daemen MJ, Dead or alive: gene expression profiles of advanced atherosclerotic plaques from autopsy and surgery. PHYSIOL GENOMICS 2007;30 (3):335-341 [PubMed]
Smook M. Adaptive immunity in atherosclerosis: an in vivio evaluation. s.l.: s.n.; 2007. 208p. ISBN 9789081171717 Proefschrift Universiteit Maastricht, Immunologie. (Promotor(s): Daemen M, Cohen Tervaert JW; copromotor(s): Lutgens E, Heeringa P)
Volger OL, Fledderus JO, Kisters N, Fontijn RD, Moerland PD, Kuiper J, van Berkel TJ, Bijnens APJJ, Daemen MJAP, Pannekoek H, Horrevoets AJG, Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis. AM J PATHOL 2007;171 (1):326-337 [PubMed]
Bijnens APJJ, Lutgens E, Ayoubi T, Kuiper J, Horrevoets AJ, Daemen MJAP, Genome-wide expression studies of atherosclerosis: critical issues in methodology, analysis, interpretation of transcriptomics data. ARTERIOSCL THROM VAS 2006;26 (6):1226-1235 [PubMed]
Cheng C, Tempel D, van Haperen R, van der Baan A, Grosveld F, Daemen MJAP, Krams R, de Crom R, Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. CIRCULATION 2006;113 (23):2744-2753 [PubMed]
Lobbes MBI, Lutgens E, Heeneman S, Cleutjens KBJM, Kooi ME, van Engelshoven JMA, Daemen MJAP, Nelemans PJ, Is there more than C-reactive protein and fibrinogen? The prognostic value of soluble CD40 ligand, interleukin-6 and oxidized low-density lipoprotein with respect to coronary and cerebral vascular disease. ATHEROSCLEROSIS 2006;187 (1):18-25 [PubMed]
Lutgens E, Lutgens SPM, Faber BCG, Heeneman S, Gijbels MMJ, de Winther MPJ, Frederik P, van der Made I, Daugherty A, Sijbers AM, Fisher A, Long CJ, Saftig P, Black D, Daemen MJAP, Cleutjens KBJM, Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation. CIRCULATION 2006;113 (1):98-107 [PubMed]
Lutgens SPM, Kisters N, Lutgens E, van Haaften RIM, Evelo CTA, de Winther MPJ, Saftig P, Daemen MJAP, Heeneman S, Cleutjens KBJM, Gene profiling of cathepsin K deficiency in atherogenesis: profibrotic but lipogenic. J PATHOL 2006;210 (3):334-343 [PubMed]
Mulder WJM, Douma K, Koning GA, van Zandvoort MA, Lutgens E, Daemen MJ, Nicolay K, Strijkers GJ, Liposome-enhanced MRI of neointimal lesions in the ApoE-KO mouse. MAGN RESON MED 2006;55 (5):1170-1174 [PubMed]
Pires NMM, Jukema JW, Daemen MJAP, Quax PHA, Drug-eluting stents studies in mice: do we need atherosclerosis to study restenosis?. VASC PHARMACOL 2006;44 (5):257-264 [PubMed]
Stewart FA, Heeneman S, te Poele J, Kruse J, Russell NS, Gijbels M, Daemen M, Ionizing radiation accelerates the development of atherosclerotic lesions in ApoE-/- mice and predisposes to an inflammatory plaque phenotype prone to hemorrhage. AM J PATHOL 2006;168 (2):649-658 [PubMed]
Xia Qg, Reinecke A, Dorenkamp M, Daemen MJAP, Simon R, Unger T, Effects of endothelin ETA receptor blocker LU 135252 on cardiac remodeling and survival in a hypertensive rat model of chronic heart failure. ACTA PHARMACOL SIN 2006;27 (11):1417-1422 [PubMed]
Cappendijk VC, Cleutjens KBJM, Kessels AGH, Heeneman S, Schurink GWH, Welten RJTJ, Mess WH, Daemen MJAP, van Engelshoven JMA, Kooi ME, Assessment of human atherosclerotic carotid plaque components with multisequence MR imaging: initial experience. RADIOLOGY 2005;234 (2):487-492 [PubMed]
Curfs DMJ, Knaapen AM, Pachen DMFA, Gijbels MJJ, Lutgens E, Smook MLF, Kockx MM, Daemen MJAP, van Schooten FJ, Polycyclic aromatic hydrocarbons induce an inflammatory atherosclerotic plaque phenotype irrespective of their DNA binding properties. FASEB J 2005;19 (10):1290-1292 [PubMed]
Donners MMPC, Bot I, de Windt LJ, van Berkel TJC, Daemen MJAP, Biessen EAL, Heeneman S, Low-dose FK506 blocks collar-induced atherosclerotic plaque development and stabilizes plaques in ApoE-/- mice. AM J TRANSPLANT 2005;5 (6):1204-1215 [PubMed]
Donners MMPC, Verluyten MJ, Bouwman FG, Mariman ECM, Devreese B, Vanrobaeys F, van Beeumen J, van den Akker LHJM, Daemen MJAP, Heeneman S, Proteomic analysis of differential protein expression in human atherosclerotic plaque progression. J PATHOL 2005;206 (1):39-45 [PubMed]
Lutgens E, Faber B, Schapira K, Evelo CTA, van Haaften R, Heeneman S, Cleutjens KBJM, Bijnens AP, Beckers L, Porter JG, Mackay CR, Rennert P, Bailly V, Jarpe M, Dolinski B, Koteliansky V, de Fougerolles T, Daemen MJAP, Gene profiling in atherosclerosis reveals a key role for small inducible cytokines: validation using a novel monocyte chemoattractant protein monoclonal antibody. CIRCULATION 2005;111 (25):3443-3452 [PubMed]
Palmen M, Twickler MT, Daemen MJ, Cramer MJ, Doevendans PA, The role of insulin-like growth factor during a postischemic period - new insights into pathophysiologic pathways in cardiac tissue. FUTURE CARDIOL 2005;1 (4):479-488 [PubMed]
Schapira K, Lutgens E, de Fougerolles A, Sprague A, Roemen A, Gardner H, Koteliansky V, Daemen M, Heeneman S, Genetic deletion or antibody blockade of alpha1beta1 integrin induces a stable plaque phenotype in ApoE-/- mice. ARTERIOSCL THROM VAS 2005;25 (9):1917-1924 [PubMed]
Smook MLF, Heeringa P, Damoiseaux JGMC, Daemen MJAP, de Winther MPJ, Gijbels MJJ, Beckers L, Lutgens E, Tervaert JWC, Leukocyte CD40L deficiency affects the CD25(+) CD4 T cell population but does not affect atherosclerosis. ATHEROSCLEROSIS 2005;183 (2):275-282 [PubMed]
Aartsen WM, Hilgers RHP, Schiffers PMH, Daemen MJAP, de Mey JGR, Smits JFM, Changes in vascular distensibility during angiotensin-converting enzyme inhibition involve bradykinin type 2 receptors. J VASC RES 2004;41 (1):18-27 [PubMed]
Cappendijk VC, Cleutjens KBJM, Heeneman S, Schurink GWH, Welten RJTJ, Kessels AGH, van Suylen RJ, Daemen MJAP, van Engelshoven JMA, Kooi ME, In vivo detection of hemorrhage in human atherosclerotic plaques with magnetic resonance imaging. J MAGN RESON IMAGING 2004;20 (1):105-110 [PubMed]
Curfs DMJ, Lutgens E, Gijbels MJJ, Kockx MM, Daemen MJAP, van Schooten FJ, Chronic exposure to the carcinogenic compound benzo[a]pyrene induces larger and phenotypically different atherosclerotic plaques in ApoE-knockout mice. AM J PATHOL 2004;164 (1):101-108 [PubMed]
Kietselaer BLJH, Reutelingsperger CPM, Heidendal GAK, Daemen MJAP, Mess WH, Hofstra L, Narula J, Noninvasive detection of plaque instability with use of radiolabeled annexin A5 in patients with carotid-artery atherosclerosis. NEW ENGL J MED 2004;350 (14):1472-1473 [PubMed]
Kornet L, Bergen AAB, Hoeks APG, Cleutjens JP, Oostra RJ, Daemen MJ, van Soest S, Reneman RS, In patients with pseudoxanthoma elasticum a thicker and more elastic carotid artery is associated with elastin fragmentation and proteoglycans accumulation. ULTRASOUND MED BIOL 2004;30 (8):1041-1048 [PubMed]
Palmen M, Daemen MJAP, de Windt LJ, Willems J, Dassen WRM, Heeneman S, Zimmermann R, van Bilsen M, Doevendans PA, Fibroblast growth factor-1 improves cardiac functional recovery and enhances cell survival after ischemia and reperfusion: a fibroblast growth factor receptor, protein kinase C, and tyrosine kinase-dependent mechanism. J AM COLL CARDIOL 2004;44 (5):1113-1123 [PubMed]
Schieffer B, Selle T, Hilfiker A, Hilfiker-Kleiner D, Grote K, Tietge UJF, Trautwein C, Luchtefeld M, Schmittkamp C, Heeneman S, Daemen MJAP, Drexler H, Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis. CIRCULATION 2004;110 (22):3493-3500 [PubMed]
Schroen B, Heymans S, Sharma U, Blankesteijn WM, Pokharel S, Cleutjens JPM, Porter JG, Evelo CTA, Duisters R, van Leeuwen REW, Janssen BJA, Debets JJM, Smits JFM, Daemen MJAP, Crijns HJGM, Bornstein P, Pinto YM, Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy. CIRC RES 2004;95 (5):515-522 [PubMed]
van Zandvoort M, Engels W, Douma K, Beckers L, Oude Egbrink M, Daemen M, Slaaf DW, Two-photon microscopy for imaging of the (atherosclerotic) vascular wall: a proof of concept study. J VASC RES 2004;41 (1):54-63 [PubMed]
Xia Qg, Reinecke A, Dorenkamp M, Storz C, Bitterling H, Penz S, Cleutjens J, Daemen MJAP, Simon R, Unger T, Comparison of cardioprotective effects of mibefradil and ramipril in stroke-prone spontaneously hypertensive rats. ACTA PHARMACOL SIN 2004;25 (6):763-768 [PubMed]
Bijnens APJJ, Gils A, Jutten B, Faber BCG, Heeneman S, Kitslaar PJEHM, Tordoir JHM, de Vries CJM, Kroon AA, Daemen MJAP, Cleutjens KBJM, Vasculin, a novel vascular protein differentially expressed in human atherogenesis. BLOOD 2003;102 (8):2803-2810 [PubMed]
Bot I, von der Thüsen JH, Donners MMPC, Lucas A, Fekkes ML, de Jager SCA, Kuiper J, Daemen MJAP, van Berkel TJC, Heeneman S, Biessen EAL, Serine protease inhibitor Serp-1 strongly impairs atherosclerotic lesion formation and induces a stable plaque phenotype in ApoE-/-mice. CIRC RES 2003;93 (5):464-471 [PubMed]
Creemers EEJM, Davis JN, Parkhurst AM, Leenders P, Dowdy KB, Hapke E, Hauet AM, Escobar PG, Cleutjens JPM, Smits JFM, Daemen MJAP, Zile MR, Spinale FG, Deficiency of TIMP-1 exacerbates LV remodeling after myocardial infarction in mice. AM J PHYSIOL-HEART C 2003;284 (1):H364-H371 [PubMed]
Donners MMPC, Daemen MJAP, Cleutjens KBJM, Heeneman S, Inflammation and restenosis: implications for therapy. ANN MED 2003;35 (7):523-531 [PubMed]
Heeneman S, Cleutjens JP, Faber BC, Creemers EE, van Suylen RJ, Lutgens E, Cleutjens KB, Daemen MJ, The dynamic extracellular matrix: intervention strategies during heart failure and atherosclerosis. J PATHOL 2003;200 (4):516-525 [PubMed]
Kooi ME, Cappendijk VC, Cleutjens KBJM, Kessels AGH, Kitslaar PJEHM, Borgers M, Frederik PM, Daemen MJAP, van Engelshoven JMA, Accumulation of ultrasmall superparamagnetic particles of iron oxide in human atherosclerotic plaques can be detected by in vivo magnetic resonance imaging. CIRCULATION 2003;107 (19):2453-2458 [PubMed]
Lutgens E, van Suylen RJ, Faber BC, Gijbels MJ, Eurlings PM, Bijnens AP, Cleutjens KB, Heeneman S, Daemen MJAP, Atherosclerotic plaque rupture: local or systemic process?. ARTERIOSCL THROM VAS 2003;23 (12):2123-2130 [PubMed]
Smeets NWJ, Stavast-Kooy AJW, Krekels GAM, Daemen MJAP, Neumann HAM, Adjuvant cytokeratin staining in Mohs micrographic surgery for basal cell carcinoma. DERMATOL SURG 2003;29 (4):375-377 [PubMed]
Aartsen WM, Schuijt MP, Danser AHJ, Daemen MJAP, Smits JFM, The role of locally expressed angiotensin converting enzyme in cardiac remodeling after myocardial infarction in mice. CARDIOVASC RES 2002;56 (2):205-213 [PubMed]
Faber BCG, Heeneman S, Daemen MJAP, Cleutjens KBJM, Genes potentially involved in plaque rupture. CURR OPIN LIPIDOL 2002;13 (5):545-552 [PubMed]
Lutgens E, Daemen MJAP, CD40-CD40L interactions in atherosclerosis. TRENDS CARDIOVAS MED 2002;12 (1):27-32 [PubMed]
Lutgens E, Gijbels M, Smook M, Heeringa P, Gotwals P, Koteliansky VE, Daemen MJAP, Transforming growth factor-beta mediates balance between inflammation and fibrosis during plaque progression. ARTERIOSCL THROM VAS 2002;22 (6):975-982 [PubMed]
van Gijn ME, Daemen MJAP, Smits JFM, Blankesteijn WM, The wnt-frizzled cascade in cardiovascular disease. CARDIOVASC RES 2002;55 (1):16-24 [PubMed]
Blankesteijn WM, Creemers E, Lutgens E, Cleutjens JP, Daemen MJ, Smits JF, Dynamics of cardiac wound healing following myocardial infarction: observations in genetically altered mice. ACTA PHYSIOL SCAND 2001;173 (1):75-82 [PubMed]
Broeders MA, Doevendans PA, Maessen JG, van Gorsel E, Egbrink MG, Daemen MJ, Tangelder GJ, Reneman RS, van der Zee R, The human internal thoracic artery releases more nitric oxide in response to vascular endothelial growth factor than the human saphenous vein. J THORAC CARDIOV SUR 2001;122 (2):305-309 [PubMed]
Creemers EE, Cleutjens JP, Smits JF, Daemen MJ, Matrix metalloproteinase inhibition after myocardial infarction: a new approach to prevent heart failure?. CIRC RES 2001;89 (3):201-210 [PubMed]
Dhore CR, Cleutjens JP, Lutgens E, Cleutjens KB, Geusens PP, Kitslaar PJ, Tordoir JH, Spronk HM, Vermeer C, Daemen MJ, Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. ARTERIOSCL THROM VAS 2001;21 (12):1998-2003 [PubMed]
Dumont EA, Reutelingsperger CP, Smits JF, Daemen MJ, Doevendans PA, Wellens HJ, Hofstra L, Real-time imaging of apoptotic cell-membrane changes at the single-cell level in the beating murine heart. NAT MED 2001;7 (12):1352-1355 [PubMed]
Faber BC, Cleutjens KB, Niessen RL, Aarts PL, Boon W, Greenberg AS, Kitslaar PJ, Tordoir JH, Daemen MJ, Identification of genes potentially involved in rupture of human atherosclerotic plaques. CIRC RES 2001;89 (6):547-554 [PubMed]
Lutgens E, Daemen MJ, Transforming growth factor-beta: a local or systemic mediator of plaque stability?. CIRC RES 2001;89 (10):853-855 [PubMed]
Lutgens E, de Muinck ED, Heeneman S, Daemen MJ, Compensatory enlargement and stenosis develop in apoE(-/-) and apoE*3-Leiden transgenic mice. ARTERIOSCL THROM VAS 2001;21 (8):1359-1365 [PubMed]
Palmen M, Daemen MJ, Bronsaer R, Dassen WR, Zandbergen HR, Kockx M, Smits JF, van der Zee R, Doevendans PA, Cardiac remodeling after myocardial infarction is impaired in IGF-1 deficient mice. CARDIOVASC RES 2001;50 (3):516-524 [PubMed]
Sandmann S, Claas R, Cleutjens JP, Daemen MJ, Unger T, Calcium channel blockade limits cardiac remodeling and improves cardiac function in myocardial infarction-induced heart failure in rats. J CARDIOVASC PHARM 2001;37 (1):64-77 [PubMed]
van Suylen RJ, Aartsen WM, Smits JF, Daemen MJ, Dissociation of pulmonary vascular remodeling and right ventricular pressure in tissue angiotensin-converting enzyme-deficient mice under conditions of chronic alveolar hypoxia. AM J RESP CRIT CARE 2001;163 (5):1241-1245 [PubMed]
Aartsen WM, Pelsers MM, Hermens WT, Glatz JF, Daemen MJ, Smits JF, Heart fatty acid binding protein and cardiac troponin T plasma concentrations as markers for myocardial infarction after coronary artery ligation in mice. PFLUG ARCH EUR J PHY 2000;439 (4):416-422 [PubMed]
Blankesteijn WM, van Gijn ME, Essers-Janssen YP, Daemen MJ, Smits JF, Beta-catenin, an inducer of uncontrolled cell proliferation and migration in malignancies, is localized in the cytoplasm of vascular endothelium during neovascularization after myocardial infarction. AM J PATHOL 2000;157 (3):877-883 [PubMed]
Creemers E, Cleutjens J, Smits J, Heymans S, Moons L, Collen D, Daemen M, Carmeliet P, Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction. AM J PATHOL 2000;156 (6):1865-1873 [PubMed]
Dumont EA, Hofstra L, van Heerde WL, van den Eijnde S, Doevendans PA, DeMuinck E, Daemen MA, Smits JF, Frederik P, Wellens HJ, Daemen MJ, Reutelingsperger CP, Cardiomyocyte death induced by myocardial ischemia and reperfusion: measurement with recombinant human annexin-V in a mouse model. CIRCULATION 2000;102 (13):1564-1568 [PubMed]
Kliffen M, Lutgens E, Daemen MJ, de Muinck ED, Mooy CM, de Jong PT, The APO(*)E3-Leiden mouse as an animal model for basal laminar deposit. BRIT J OPHTHALMOL 2000;84 (12):1415-1419 [PubMed]
Lemson MS, Tordoir JH, Daemen MJ, Kitslaar PJ, Intimal hyperplasia in vascular grafts. EUR J VASC ENDOVASC 2000;19 (4):336-350 [PubMed]
Lutgens E, Cleutjens KB, Heeneman S, Koteliansky VE, Burkly LC, Daemen MJ, Both early and delayed anti-CD40L antibody treatment induces a stable plaque phenotype. P NATL ACAD SCI USA 2000;97 (13):7464-7469 [PubMed]
Robert-Offerman SR, Leers MP, van Suylen RJ, Nap M, Daemen MJ, Theunissen PH, Evaluation of the membrane attack complex of complement for the detection of a recent myocardial infarction in man. J PATHOL 2000;191 (1):48-53 [PubMed]
Spiering W, Kroon AA, Fuss-Lejeune MM, Daemen MJ, de Leeuw PW, Angiotensin II sensitivity is associated with the angiotensin II type 1 receptor A(1166)C polymorphism in essential hypertensives on a high sodium diet. HYPERTENSION 2000;36 (3):411-416 [PubMed]
Spitznagel H, Chung O, Xia Q, Rossius B, Illner S, Jähnichen G, Sandmann S, Reinecke A, Daemen MJ, Unger T, Cardioprotective effects of the Na(+)/H(+)-exchange inhibitor cariporide in infarct-induced heart failure. CARDIOVASC RES 2000;46 (1):102-110 [PubMed]
van Heerde WL, Robert-Offerman S, Dumont E, Hofstra L, Doevendans PA, Smits JF, Daemen MJ, Reutelingsperger CP, Markers of apoptosis in cardiovascular tissues: focus on Annexin V. CARDIOVASC RES 2000;45 (3):549-559 [PubMed]
Cleutjens JP, Blankesteijn WM, Daemen MJ, Smits JF, The infarcted myocardium: simply dead tissue, or a lively target for therapeutic interventions. CARDIOVASC RES 1999;44 (2):232-241 [PubMed]
Heymans S, Luttun A, Nuyens D, Theilmeier G, Creemers E, Moons L, Dyspersin GD, Cleutjens JP, Shipley M, Angellilo A, Levi M, Nübe O, Baker A, Keshet E, Lupu F, Herbert JM, Smits JF, Shapiro SD, Baes M, Borgers M, Collen D, Daemen MJ, Carmeliet P, Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure. NAT MED 1999;5 (10):1135-1142 [PubMed]
Lemson MS, Daemen MJ, Kitslaar PJ, Tordoir JH, A new animal model to study intimal hyperplasia in arteriovenous fistulas. J SURG RES 1999;85 (1):51-58 [PubMed]
Lutgens E, Daemen MJ, de Muinck ED, Debets J, Leenders P, Smits JF, Chronic myocardial infarction in the mouse: cardiac structural and functional changes. CARDIOVASC RES 1999;41 (3):586-593 [PubMed]
Lutgens E, Daemen M, Kockx M, Doevendans P, Hofker M, Havekes L, Wellens H, de Muinck ED, Atherosclerosis in APOE*3-Leiden transgenic mice: from proliferative to atheromatous stage. CIRCULATION 1999;99 (2):276-283 [PubMed]
Lutgens E, de Muinck ED, Kitslaar PJ, Tordoir JH, Wellens HJ, Daemen MJ, Biphasic pattern of cell turnover characterizes the progression from fatty streaks to ruptured human atherosclerotic plaques. CARDIOVASC RES 1999;41 (2):473-479 [PubMed]
Lutgens E, Gorelik L, Daemen MJ, de Muinck ED, Grewal IS, Koteliansky VE, Flavell RA, Requirement for CD154 in the progression of atherosclerosis. NAT MED 1999;5 (11):1313-1316 [PubMed]
van Suylen RJ, Wouters EF, Pennings HJ, Cheriex EC, van Pol PE, Ambergen AW, Vermelis AM, Daemen MJ, The DD genotype of the angiotensin converting enzyme gene is negatively associated with right ventricular hypertrophy in male patients with chronic obstructive pulmonary disease. AM J RESP CRIT CARE 1999;159 (6):1791-1795 [PubMed]
Bruijns RH, van Kleef EM, Smits JF, de Mey JG, Daemen MJ, Effects of chemical sympathectomy on angiotensin II-induced neointimal growth in the balloon-injured rat carotid artery. J VASC RES 1998;35 (2):124-133 [PubMed]
Davidse JH, van der Veen FH, Lucas CM, Penn OC, Daemen MJ, Wellens HJ, Structural alterations in the latissimus dorsi muscles in three patients more than 2 years after a cardiomyoplasty procedure. EUR HEART J 1998;19 (2):310-318 [PubMed]
de Vreede-Swagemakers JJ, Gorgels AP, Dubois-Arbouw WI, Dalstra J, Daemen MJ, van Ree JW, Stijns RE, Wellens HJ, Circumstances and causes of out-of-hospital cardiac arrest in sudden death survivors. HEART 1998;79 (4):356-361 [PubMed]
Doevendans PA, Daemen MJ, de Muinck ED, Smits JF, Cardiovascular phenotyping in mice. CARDIOVASC RES 1998;39 (1):34-49 [PubMed]
Kuizinga MC, Smits JF, Arends JW, Daemen MJAP, AT2 receptor blockade reduces cardiac interstitial cell DNA synthesis and cardiac function after rat myocardial infarction. J MOL CELL CARDIOL 1998;30 (2):425-434 [PubMed]
Nelissen-Vrancken HJ, Kuizinga MC, Daemen MJ, Smits JF, Early captopril treatment inhibits DNA synthesis in endothelial cells and normalization of maximal coronary flow in infarcted rat hearts. CARDIOVASC RES 1998;40 (1):156-164 [PubMed]
Nickenig G, Bäumer AT, Grohè C, Kahlert S, Strehlow K, Rosenkranz S, Stäblein A, Beckers F, Smits JF, Daemen MJ, Vetter H, Böhm M, Estrogen modulates AT1 receptor gene expression in vitro and in vivo. CIRCULATION 1998;97 (22):2197-2201 [PubMed]
Nijhuis PH, van den Bogaard TE, Daemen MJ, Baeten CG, Perianal injection of polydimethylsiloxane (Bioplastique implants) paste in the treatment of soiling: pilot study in rats to determine migratory tendency and locoregional reaction. DIS COLON RECTUM 1998;41 (5):624-629 [PubMed]
Rodriguez LM, Leunissen J, Hoekstra A, Korteling BJ, Smeets JL, Timmermans C, Vos M, Daemen M, Wellens HJ, Transvenous cold mapping and cryoablation of the AV node in dogs: observations of chronic lesions and comparison to those obtained using radiofrequency ablation. J CARDIOVASC ELECTR 1998;9 (10):1055-1061 [PubMed]
Sandmann S, Spitznagel H, Chung O, Xia QG, Illner S, Jänichen G, Rossius B, Daemen MJ, Unger T, Effects of the calcium channel antagonist mibefradil on haemodynamic and morphological parameters in myocardial infarction-induced cardiac failure in rats. CARDIOVASC RES 1998;39 (2):339-350 [PubMed]
Smits JF, Passier RC, Daemen MJ, Should we aim at tissue renin-angiotensin systems?. PHARM WORLD SCI 1998;20 (3):93-99 [PubMed]
Spiering W, Kroon AA, Vreugdenhil HA, Geraedts JP, Daemen MJ, de Leeuw PW, Samenhang tussen genetische polymorfismen en ziekte geïllustreerd aan het renine-angiotensine-aldosteronsysteem en cardiovasculaire aandoeningen. NED TIJDSCHR GENEESKD 1998;142 (25):1445-1450 [PubMed]
Su EJ, Lombardi DM, Wiener J, Daemen MJ, Reidy MA, Schwartz SM, Mitogenic effect of angiotensin II on rat carotid arteries and type II or III mesenteric microvessels but not type I mesenteric microvessels is mediated by endogenous basic fibroblast growth factor. CIRC RES 1998;82 (3):321-327 [PubMed]
van Suylen RJ, Smits JF, Daemen MJ, Pulmonary artery remodeling differs in hypoxia- and monocrotaline-induced pulmonary hypertension. AM J RESP CRIT CARE 1998;157 (5 Part 1):1423-1428 [PubMed]
Verkeste CM, Slangen BF, Daemen M, van Straaten H, Kohnen G, Kaufmann P, Peeters LL, The extent of trophoblast invasion in the preplacental vasculature of the guinea-pig. PLACENTA 1998;19 (1):49-54 [PubMed]
Volders PG, Daemen MJ, Interstitial fibrosis and angiotensin-converting enzyme inhibition in patients with end-stage myocardial infarction. J AM COLL CARDIOL 1998;32 (2):552-553 [PubMed]
Vos MA, de Groot SH, Verduyn SC, van der Zande J, Leunissen HD, Cleutjens JP, van Bilsen M, Daemen MJ, Schreuder JJ, Allessie MA, Wellens HJ, Enhanced susceptibility for acquired torsade de pointes arrhythmias in the dog with chronic, complete AV block is related to cardiac hypertrophy and electrical remodeling. CIRCULATION 1998;98 (11):1125-1135 [PubMed]
Blankesteijn WM, Essers-Janssen YP, Verluyten MJ, Daemen MJ, Smits JF, A homologue of Drosophila tissue polarity gene frizzled is expressed in migrating myofibroblasts in the infarcted rat heart. NAT MED 1997;3 (5):541-544 [PubMed]
Daemen MJ, Urata H, Healing human myocardial infarction associated with increased chymase immunoreactivity. HEART VESSELS 1997;12 (Suppl. 12):113-115 [PubMed]
de Vreede-Swagemakers JJ, Gorgels AP, Dubois-Arbouw WI, van Ree JW, Daemen MJ, Houben LG, Wellens HJ, Out-of-hospital cardiac arrest in the 1990's: a population-based study in the Maastricht area on incidence, characteristics and survival. J AM COLL CARDIOL 1997;30 (6):1500-1505 [PubMed]
Heeneman S, Smits JF, Leenders PJ, Schiffers PM, Daemen MJ, Effects of angiotensin II on cardiac function and peripheral vascular structure during compensated heart failure in the rat. ARTERIOSCL THROM VAS 1997;17 (10):1985-1994 [PubMed]
Persoons MC, Daemen MJ, van Kleef EM, Grauls GE, Wijers E, Bruggeman CA, Neointimal smooth muscle cell phenotype is important in its susceptibility to cytomegalovirus (CMV) infection: a study in rat. CARDIOVASC RES 1997;36 (2):282-288 [PubMed]
Scheidegger KJ, Nelissen-Vrancken MH, Leenders PJ, Daemen MJ, Smits JF, Wood JM, Structural adaptation to ischemia in skeletal muscle: effects of blockers of the renin-angiotensin system. J HYPERTENS 1997;15 (12 Part 1):1455-1462 [PubMed]
Ulrich MM, Janssen AM, Daemen MJ, Rappaport L, Samuel JL, Contard F, Smits JF, Cleutjens JP, Increased expression of fibronectin isoforms after myocardial infarction in rats. J MOL CELL CARDIOL 1997;29 (9):2533-2543 [PubMed]
deBlois D, Schwartz SM, van Kleef EM, Su JE, Griffin KA, Bidani AK, Daemen MJ, Lombardi DM, Chronic alpha 1-adrenoreceptor stimulation increases DNA synthesis in rat arterial wall. Modulation of responsiveness after vascular injury. ARTERIOSCL THROM VAS 1996;16 (9):1122-1129 [PubMed]
Hofstra L, Tordoir JH, Kitslaar PJ, Hoeks AP, Daemen MJ, Enhanced cellular proliferation in intact stenotic lesions derived from human arteriovenous fistulas and peripheral bypass grafts. Does it correlate with flow parameters?. CIRCULATION 1996;94 (6):1283-1290 [PubMed]
Nelissen-Vrancken HJ, Debets JJ, Snoeckx LH, Daemen MJ, Smits JF, Time-related normalization of maximal coronary flow in isolated perfused hearts of rats with myocardial infarction. CIRCULATION 1996;93 (2):349-355 [PubMed]
Passier RC, Smits JF, Verluyten MJ, Daemen MJ, Expression and localization of renin and angiotensinogen in rat heart after myocardial infarction. AM J PHYSIOL 1996;271 (3 Part 2):H1040-H1048 [PubMed]
van Kleef EM, Fingerle J, Daemen MJ, Angiotensin II-induced progression of neointimal thickening in the balloon-injured rat carotid artery is AT1 receptor mediated. ARTERIOSCL THROM VAS 1996;16 (7):857-863 [PubMed]
van Kleef EM, Smits JF, Schwartz SM, Daemen MJ, Doxazosin blocks the angiotensin II-induced smooth muscle cell DNA synthesis in the media, but not in the neointima of the rat carotid artery after balloon injury. CARDIOVASC RES 1996;31 (2):324-330 [PubMed]
van Ommen VG, van der Veen FH, Geskes GG, Daemen M, Habets J, Dassen WR, Wellens HJ, Comparison of arterial wall reaction after passage of the Hydrolyser device versus a thrombectomy balloon in an animal model. J VASC INTERV RADIOL 1996;7 (3):451-454 [PubMed]
Willems IE, Arends JW, Daemen MJ, Tenascin and fibronectin expression in healing human myocardial scars. J PATHOL 1996;179 (3):321-325 [PubMed]
Cleutjens JP, Verluyten MJ, Smiths JF, Daemen MJ, Collagen remodeling after myocardial infarction in the rat heart. AM J PATHOL 1995;147 (2):325-338 [PubMed]
Daemen MJ, de Mey JG, Regional heterogeneity of arterial structural changes. HYPERTENSION 1995;25 (4 Part 1):464-473 [PubMed]
Engels W, Reiters PH, Daemen MJ, Smits JF, van der Vusse GJ, Transmural changes in mast cell density in rat heart after infarct induction in vivo. J PATHOL 1995;177 (4):423-429 [PubMed]
Heeneman S, Leenders PJ, Aarts PJ, Smits JF, Arends JW, Daemen MJ, Peripheral vascular alterations during experimental heart failure in the rat. Do they exist?. ARTERIOSCL THROM VAS 1995;15 (9):1503-1511 [PubMed]
Hofstra L, Bergmans DC, Leunissen KM, Hoeks AP, Kitslaar PJ, Daemen MJ, Tordoir JH, Anastomotic intimal hyperplasia in prosthetic arteriovenous fistulas for hemodialysis is associated with initial high flow velocity and not with mismatch in elastic properties. J AM SOC NEPHROL 1995;6 (6):1625-1633 [PubMed]
Kooman JP, Daemen MJ, Wijnen R, Verluyten-Goessens MJ, van Hooff JP, Leunissen KM, Morphological changes of the venous system in uremic patients. A histopathologic study. NEPHRON 1995;69 (4):454-458 [PubMed]
Koskinen P, Lemström K, Bruning H, Daemen M, Bruggeman C, Häyry P, Cytomegalovirus infection induces vascular wall inflammation and doubles arteriosclerotic changes in rat cardiac allografts. TRANSPL P 1995;27 (1):574-575 [PubMed]
Lemström K, Koskinen P, Krogerus L, Daemen M, Bruggeman C, Häyry P, Cytomegalovirus antigen expression, endothelial cell proliferation, and intimal thickening in rat cardiac allografts after cytomegalovirus infection. CIRCULATION 1995;92 (9):2594-2604 [PubMed]
Passier RC, Smits JF, Verluyten MJ, Studer R, Drexler H, Daemen MJ, Activation of angiotensin-converting enzyme expression in infarct zone following myocardial infarction. AM J PHYSIOL 1995;269 (4 Part 2):H1268-H1276 [PubMed]
Smits JF, Passier RC, Nelissen-Vrancken HJ, Cleutjens JP, Kuizinga MC, Daemen MJ, Does ACE inhibition limit structural changes in the heart following myocardial infarction?. EUR HEART J 1995;16 (Suppl. N):46-51 [PubMed]
Persoons MC, Daemen MJ, Bruning JH, Bruggeman CA, Active cytomegalovirus infection of arterial smooth muscle cells in immunocompromised rats. A clue to herpesvirus-associated atherogenesis?. CIRC RES 1994;75 (2):214-220 [PubMed]
Smits JF, Daemen MJ, Insights from animal models of myocardial infarction: do ACE inhibitors limit the structural response?. BRIT HEART J 1994;72 (3 Suppl):S61-S64 [PubMed]
Tjandra BS, Daemen MJ, Weil EH, Papillary mesothelioma of the albuginea testis. UROLOGY 1994;43 (1):118-120 [PubMed]
van Ommen V, van der Veen FH, Daemen MJ, Habets J, Wellens HJ, In vivo evaluation of the Hydrolyser hydrodynamic thrombectomy catheter. J VASC INTERV RADIOL 1994;5 (6):823-826 [PubMed]
Willems IE, Havenith MG, de Mey JG, Daemen MJ, The alpha-smooth muscle actin-positive cells in healing human myocardial scars. AM J PATHOL 1994;145 (4):868-875 [PubMed]
Willems IE, Havenith MG, Smits JF, Daemen MJ, Structural alterations in heart valves during left ventricular pressure overload in the rat. LAB INVEST 1994;71 (1):127-133 [PubMed]
Boonen HC, Daemen MJ, Eerdmans PH, Fazzi GE, van Kleef EM, Schiffers PM, de Mey JG, Mesenteric small artery changes after vasoconstrictor infusion in young rats. J CARDIOVASC PHARM 1993;22 (3):388-395 [PubMed]
Nelissen-Vrancken HJ, Boudier HA, Daemen MJ, Smits JF, Antihypertensive therapy and adaptive mechanisms in peripheral ischemia. HYPERTENSION 1993;22 (5):780-788 [PubMed]
Volders PG, Willems IE, Cleutjens JP, Arends JW, Havenith MG, Daemen MJ, Interstitial collagen is increased in the non-infarcted human myocardium after myocardial infarction. J MOL CELL CARDIOL 1993;25 (11):1317-1323 [PubMed]
Smits JF, van Krimpen C, Schoemaker RG, Cleutjens JP, Daemen MJ, Angiotensin II receptor blockade after myocardial infarction in rats: effects on hemodynamics, myocardial DNA synthesis, and interstitial collagen content. J CARDIOVASC PHARM 1992;20 (5):772-778 [PubMed]
van Kleef EM, Smits JF, de Mey JG, Cleutjens JP, Lombardi DM, Schwartz SM, Daemen MJ, Alpha 1-adrenoreceptor blockade reduces the angiotensin II-induced vascular smooth muscle cell DNA synthesis in the rat thoracic aorta and carotid artery. CIRC RES 1992;70 (6):1122-1127 [PubMed]
Bär FW, van Oppen J, de Swart H, van Ommen V, Havenith M, Daemen M, Leenders P, van der Veen FH, van Lankveld M, Verduin M, Percutaneous implantation of a new intracoronary stent in pigs. AM HEART J 1991;122 (6):1532-1541 [PubMed]
Boonen HC, Schiffers PM, Fazzi GE, Janssen GM, Daemen MJ, de Mey JG, DNA synthesis in isolated arteries. Kinetics and structural consequences. AM J PHYSIOL 1991;260 (1 Part 2):H210-H217 [PubMed]
Daemen MJ, Lombardi DM, Bosman FT, Schwartz SM, Angiotensin II induces smooth muscle cell proliferation in the normal and injured rat arterial wall. CIRC RES 1991;68 (2):450-456 [PubMed]
de Mey JG, Daemen MJ, Boonen HC, Bosman FT, Dijkstra EH, Fazzi GE, Janssen GM, Schiffers PM, Struyker-Boudier HA, Vrijdag MJ, In vivo DNA synthesis is not uniformly increased in arterial smooth muscle of young spontaneously hypertensive rats. J HYPERTENS 1991;9 (8):695-701 [PubMed]
Hendrix MG, Daemen M, Bruggeman CA, Cytomegalovirus nucleic acid distribution within the human vascular tree. AM J PATHOL 1991;138 (3):563-567 [PubMed]
Smits JF, Cleutjens JP, van Krimpen C, Schoemaker RG, Daemen MJ, Cardiac remodeling in hypertension and following myocardial infarction: effects of arteriolar vasodilators. BASIC RES CARDIOL 1991;86 (Suppl. 1):133-139 [PubMed]
van Krimpen C, Schoemaker RG, Cleutjens JP, Smits JF, Struyker-Boudier HA, Bosman FT, Daemen MJ, Angiotensin I converting enzyme inhibitors and cardiac remodeling. BASIC RES CARDIOL 1991;86 (Suppl. 1):149-155 [PubMed]
van Krimpen C, Smits JF, Cleutjens JP, Debets JJ, Schoemaker RG, Struyker Boudier HA, Bosman FT, Daemen MJ, DNA synthesis in the non-infarcted cardiac interstitium after left coronary artery ligation in the rat: effects of captopril. J MOL CELL CARDIOL 1991;23 (11):1245-1253 [PubMed]
Majesky MW, Daemen MJ, Schwartz SM, Alpha 1-adrenergic stimulation of platelet-derived growth factor A-chain gene expression in rat aorta. J BIOL CHEM 1990;265 (2):1082-1088 [PubMed]
Ruers TJ, Buurman WA, Daemen MJ, van der Linden CJ, Kootstra G, Local budesonide treatment of rat cardiac allografts results in effective immunosuppression without systemic immunological side effects. TRANSPL P 1990;22 (4):1998-1999 [PubMed]
Daemen MJ, Smits JF, Thijssen HH, Struyker Boudier HA, Orgaan-gerichte toediening van geneesmiddelen; zin en onzin. NED TIJDSCHR GENEESKD 1989;133 (42):2063-2067 [PubMed]
Daemen MJ, Thijssen HH, van Essen H, Vervoort-Peters HT, Prinzen FW, Struyker Boudier HA, Smits JF, Liver blood flow measurement in the rat. The electromagnetic versus the microsphere and the clearance methods. J PHARMACOL METHODS 1989;21 (4):287-297 [PubMed]
de Mey JG, Uitendaal MP, Boonen HC, Vrijdag MJ, Daemen MJ, Struyker-Boudier HA, Acute and long-term effects of tissue culture on contractile reactivity in renal arteries of the rat. CIRC RES 1989;65 (4):1125-1135 [PubMed]
Daemen MJ, Smits JF, Thijssen HH, Struyker-Boudier HA, Pharmacokinetic considerations in target-organ directed drug delivery. TRENDS PHARMACOL SCI 1988;9 (4):138-141 [PubMed]
Daemen MJ, Vervoort-Peters HT, Thijssen HH, Pharmacokinetic evaluation of local drug delivery: the intratesticular and intrarenal administration of acenocoumarol in the rat. J PHARM PHARMACOL 1988;40 (4):283-285 [PubMed]
Ruers TJ, Daemen MJ, Thijssen HH, van der Linden CJ, Buurman WA, Sensitivity of graft rejection in rats to local immunosuppressive therapy. TRANSPLANTATION 1988;46 (6):820-825 [PubMed]
Daemen MJ, Thijssen HH, van Essen H, Smits JF, Struyker-Boudier HA, Target organ directed drug delivery: evaluation of renal infusion of chromium-51 ethylenediaminetetraacetate and sodium o-[125I]iodohippurate in the Wistar Kyoto rat. J PHARM SCI-US 1986;75 (12):1137-1140 [PubMed]
Daemen MJ, Thijssen HH, Vervoort-Peters HT, Smits JF, Struyker Boudier HA, The effect of pentobarbitone anaesthesia and hypothermia on the hepatic clearance of indocyanine green and S(-)-acenocoumarol in the rat. J PHARM PHARMACOL 1986;38 (2):122-125 [PubMed]
Daemen MJ, Vervoort-Peters HT, Thijssen HH, Apparent dose dependency of the hepatic (S)-acenocoumarol clearance in the rat: a study using open liver biopsies. J PHARM SCI-US 1986;75 (3):238-240 [PubMed]
de Koning RW, Daemen M, Schutte B, Geertzen HG, Blijham GH, Bosman FT, Immunofluorescence detection of liver cell membrane autoantibodies using PLC/PRF/5 cells. EUR J CLIN INVEST 1985;15 (2):64-68 [PubMed]
Vermeer C, Hendrix H, Daemen M, Vitamin K-dependent carboxylases from non-hepatic tissues. FEBS LETT 1982;148 (2):317-320 [PubMed]
Key publications

Ritz K, Denswil NP, Stam OCG, van Lieshout JJ, Daemen MJAP, Cause and mechanisms of intracranial atherosclerosis. CIRCULATION 2014;130 (16):1407-1414 [PubMed]
Bink DI, Ritz K, Aronica E, van der Weerd L, Daemen MJAP, Mouse models to study the effect of cardiovascular risk factors on brain structure and cognition. J CEREBR BLOOD F MET 2013;33 (11):1666-1684 [PubMed]
van der Valk FM, Sluimer JC, Vöö SA, Verberne HJ, Nederveen AJ, Windhorst AD, Stroes ESG, Lambin P, Daemen MJAP, In Vivo Imaging of Hypoxia in Atherosclerotic Plaques in Humans. JACC-CARDIOVASC IMAG 2015;8 (11):1340-1341 [PubMed]
Daemen MJ, Ferguson MS, Gijsen FJ, Hippe DS, Kooi ME, Demarco K, van der Wal AC, Yuan C, Hatsukami TS, Carotid plaque fissure: An underestimated source of intraplaque hemorrhage. ATHEROSCLEROSIS 2016;254:102-108 [PubMed]
Marsch E, Sluimer JC, Daemen MJAP, Hypoxia in atherosclerosis and inflammation. CURR OPIN LIPIDOL 2013;24 (5):393-400 [PubMed]


All Publications

Research programmes

Molecular Mechanism, Imaging and Pathology of atherosclerosis

In the last 6 years the research is moving from plaque instability and imaging in the carotid artery, which was supported by the CTMM grant PARISK (PI M. Daemen) to features and mechanisms of intracranial atherosclerosis. This develops some 20 years later than extracranial atherosclerosis andshow special features such as plaque fibrosis, less plaque inflammation, while intraplque hemorrhage is rare. Even more interesting is our observation that intracranial atherosclerosis is absent in those mouse strains that develop severe extracranial atherosclerosis. We hypothesize that the intracranial endothelial cells are protective against atherosclerotic stimuli and have started mechanistic studies in collaboration with Elga de Vries (VUmc). A collaboration with Han van Lieshout (AMC) and Thijs van Osch (LUMC) focusses on the role of autoregulation in the brain (Rembrandt grant).

A CVON consortium grant (PI's M. Daemen and M. van Buchem (LUMC) called the Heart Brain Connection evaluates the hypothesis that cerebral hypoperfusion is associated with a decline of cognition and with structural brain alteraions. This is investigated in a clinical study, in the Rotterdam study and in several experimental studies. including those in mice in which we investigate the effects of cerebral hypoperfusion in mice. Non invasive imaging of intracranial vessels is quite challenging and lacks a head to head comparison with histology. To fill that gap we have started a collaboration with Jeroen Hendrikse (UMCU) who perform 3T and 7T imaging of intracanial arteries. This has resulted in a joint STW grant called Brain&Risk in which we will compare histological and non-invasive imaging features of intracranial arteries. 

Faculty
Prof. dr. M.J.A.P. Daemen

Postdocs
Dr. D. Hermkens
Dr. O. Soehnlein

PhD Students
Q. Braster MSc
Drs. N.P. Denswil
Drs. M.I. Liem MD
S. Scheffer
O.C.G. Stam
Ing. J. Verbree (LUMC)

Others
C. Mackaaij BSc
J.P.H.M. Ploegmakers BSc

Prof. A.C. van der Wal MD PhD (Cardiovascular Pathology)

Other research related activities
  • Membership of medical or scientific committee, Nederlandse Hartstichting, Netherlands Heart Institute, CVON
  • Stock / Shareholder, ACS Biomarker
  • Membership of editorial board / Editorship, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
  • Membership of medical or scientific committee, Other, DZHK Translational Research
  • Membership of medical or scientific committee, Lygature, European Lead Factory
  • Board of directors / Trustees / Supervisory board, PALGA
  • Membership of medical or scientific committee, ZonMw (Netherlands Organisation for Health Research and Development), Meer Kennis met minder dieren
Current research funding
  • AMC (Vrijgesteld)
  • Nederlandse Hartstichting
  • Technologiestichting STW
  • ZonMw