• Principal Investigator
  • Female

Prof. dr. T.J. Roseboom PhD

Position: Professor
Main activities: Research, Teaching
Specialisation: Early Development and Health
foto T.J. Roseboom is one of the AMC Principal Investigators
Focus of research:

Early Development and Health

Like all other living creatures, humans are capable of adapting to their environment. There is a large body of evidence to demonstrate that the environment around the time of conception and in very early life has a lasting effect on later health and lifespan. The life course approach to health and disease recognises that very early environmental influences contribute to an individual’s later susceptibility to the various chronic diseases that plague our society. From this perspective, research in this area focusses on various interventions and environmental stimuli during early development and their effects on later health.

AMC themes: Public Health & Epidemiology, Reproduction and development
Departments: Clinical Epidemiology, Biostatistics and Bioinformatics, Obstetrics and Gynaecology
Ambeskovic M, Roseboom TJ, Metz GAS, Transgenerational Effects of Early Environmental Insults on Aging and Disease Incidence. NEUROSCI BIOBEHAV R 2017;ahead of print [PubMed]
Bleker LS, Roseboom TJ, Vrijkotte TG, Reynolds RM, de Rooij SR, Determinants of cortisol during pregnancy - The ABCD cohort. PSYCHONEUROENDOCRINO 2017;83:172-181 [PubMed]
Cao-Lei L, de Rooij SR, King S, Matthews SG, Metz GAS, Roseboom TJ, Szyf M, Prenatal Stress and Epigenetics. NEUROSCI BIOBEHAV R 2017;ahead of print [PubMed]
Franke K, Gaser C, de Rooij SR, Schwab M, Roseboom TJ, Premature brain aging in humans exposed to maternal nutrient restriction during early gestation. NEUROIMAGE 2017;ahead of print [PubMed]
Grooten IJ. Barriers and challenges in hyperemesis gravidarum research. S.l.: s.n.; 2017. 213p. ISBN 978-94-6299-669-4 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Roseboom TJ, van der Post JAM; copromotor(s): Painter RC)
Grooten IJ, den Hollander WJ, Roseboom TJ, Kuipers EJ, Jaddoe VW, Gaillard R, Painter RC, Helicobacter pylori infection: a predictor of vomiting severity in pregnancy and adverse birth outcome. AM J OBSTET GYNECOL 2017;216 (5):512.e1-512.e9 [PubMed]
Grooten IJ, Koot MH, van der Post JA, Bais JM, Ris-Stalpers C, Naaktgeboren C, Bremer HA, van der Ham DP, Heidema WM, Huisjes A, Kleiverda G, Kuppens S, van Laar JO, Langenveld J, van der Made F, van Pampus MG, Papatsonis D, Pelinck MJ, Pernet PJ, van Rheenen L, Rijnders RJ, Scheepers HC, Vogelvang TE, Mol BW, Roseboom TJ, Painter RC, Early enteral tube feeding in optimizing treatment of hyperemesis gravidarum: the Maternal and Offspring outcomes after Treatment of HyperEmesis by Refeeding (MOTHER) randomized controlled trial. AM J CLIN NUTR 2017;106 (3):812-820 [PubMed]
Horenblas J, de Rooij SR, Roseboom TJ, The risk of stroke after prenatal exposure to famine. J DEV ORIG HLTH DIS 2017;8 (6):658-664 [PubMed]
Koot MH, Grooten IJ, Sebert S, Koiranen M, Järvelin MR, Kajantie E, Painter RC, Roseboom TJ, Hyperemesis gravidarum and cardiometabolic risk factors in adolescents: a follow-up of the Northern Finland Birth Cohort 1986. BJOG-INT J OBSTET GY 2017;124 (7):1107-1114 [PubMed]
Kuiper D, Bennema A, La Bastide-van Gemert S, Seggers J, Schendelaar P, Mastenbroek S, Hoek A, Heineman MJ, Roseboom TJ, Kok JH, Hadders-Algra M, Developmental outcome of 9-year-old children born after PGS: follow-up of a randomized trial. HUM REPROD 2017;ahead of print [PubMed]
Oostvogels AJJM. Maternal characteristics and offspring’s cardiometabolic profile. S.l.: s.n.; 2017. 275p. ISBN 978-94-6299-744-8 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Stronks K, Roseboom TJ; copromotor(s): Vrijkotte TGM)
Oostvogels AJJM, Busschers WB, Spierings EJM, Roseboom TJ, Gademan MGJ, Vrijkotte TGM, Pre-pregnancy weight status, early pregnancy lipid profile and blood pressure course during pregnancy: The ABCD study. PLOS ONE 2017;12 (5):e0177554 [PubMed]
Oostvogels AJJM, Hof MHP, Gademan MGJ, Roseboom TJ, Stronks K, Vrijkotte TGM, Does maternal pre-pregnancy overweight or obesity influence offspring's growth patterns from birth up to 7years? The ABCD-study. EARLY HUM DEV 2017;113:62-70 [PubMed]
Oostvogels AJJM, Landstra CP, Britsemmer L, Lodewijkx R, Stronks K, Roseboom TJ, Vrijkotte TGM, Maternal and paternal family history of diabetes in second-degree relatives and metabolic outcomes at age 5-6 years: The ABCD Study. DIABETES METAB 2017;43 (4):338-344 [PubMed]
van den Bergh BRH, van den Heuvel MI, Lahti M, Braeken M, de Rooij SR, Entringer S, Hoyer D, Roseboom T, Räikkönen K, King S, Schwab M, Prenatal developmental origins of behavior and mental health: the influence of maternal stress in pregnancy. NEUROSCI BIOBEHAV R 2017;ahead of print [PubMed]
Al Wattar BH, Dodds J, Placzek A, Spyreli E, Moore A, Hooper R, Beresford L, Roseboom TJ, Bes-Rastrollo M, Hitman G, Khan KS, Thangaratinam S, Effect of simple, targeted diet in pregnant women with metabolic risk factors on maternal and fetal outcomes (ESTEEM): study protocol for a pragmatic multicentre randomised trial. BMJ OPEN 2016;6 (10):e013495 [PubMed]
Bleker LS, de Rooij SR, Painter RC, van der Velde N, Roseboom TJ, Prenatal Undernutrition and Physical Function and Frailty at the Age of 68 Years: The Dutch Famine Birth Cohort Study. J GERONTOL A-BIOL 2016;71 (10):1306-1314 [PubMed]
Brindle RC, Ginty AT, Jones A, Phillips AC, Roseboom TJ, Carroll D, Painter RC, de Rooij SR, Cardiovascular reactivity patterns and pathways to hypertension: a multivariate cluster analysis. J HUM HYPERTENS 2016;30 (12):755-760 [PubMed]
de Rooij SR, Caan MWA, Swaab DF, Nederveen AJ, Majoie CB, Schwab M, Painter RC, Roseboom TJ, Prenatal famine exposure has sex-specific effects on brain size. BRAIN 2016;139 (Part 8):2136-2142 [PubMed]
de Rooij SR, Jones A, Phillips DI, Osmond C, Karemaker JM, Roseboom TJ, Painter RC, Prenatal Undernutrition and Autonomic Function in Adulthood. PSYCHOSOM MED 2016;78 (9):991-997 [PubMed]
Ginty AT, Williams SE, Jones A, Roseboom TJ, Phillips AC, Painter RC, Carroll D, de Rooij SR, Diminished heart rate reactivity to acute psychological stress is associated with enhanced carotid intima-media thickness through adverse health behaviors. PSYCHOPHYSIOLOGY 2016;53 (6):769-775 [PubMed]
Grooten IJ, Mol BW, van der Post JAM, Ris-Stalpers C, Kok M, Bais JMJ, Bax CJ, Duvekot JJ, Bremer HA, Porath MM, Heidema WM, Bloemenkamp KWM, Scheepers HCJ, Franssen MTM, Oudijk MA, Roseboom TJ, Painter RC, Early nasogastric tube feeding in optimising treatment for hyperemesis gravidarum: the MOTHER randomised controlled trial (Maternal and Offspring outcomes after Treatment of HyperEmesis by Refeeding). BMC PREGNANCY CHILDB 2016;16 (1):22 [PubMed]
Krikke GG, Grooten IJ, Vrijkotte TGM, van Eijsden M, Roseboom TJ, Painter RC, Vitamin B-12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6years: findings from the ABCD multi-ethnic birth cohort. BJOG-INT J OBSTET GY 2016;123 (3):384-392 [PubMed]
Seggers J, Pontesilli M, Ravelli ACJ, Painter RC, Hadders-Algra M, Heineman MJ, Repping S, Mol BWJ, Roseboom TJ, Ensing S, Effects of in vitro fertilization and maternal characteristics on perinatal outcomes: a population-based study using siblings. FERTIL STERIL 2016;105 (3):590-+ [PubMed]
de Rooij SR, van Pelt AMM, Ozanne SE, Korver CM, van Daalen SKM, Painter RC, Schwab M, Viegas MH, Roseboom TJ, Prenatal undernutrition and leukocyte telomere length in late adulthood: the Dutch famine birth cohort study. AM J CLIN NUTR 2015;102 (3):655-660 [PubMed]
Ensing S, Abu-Hanna A, Roseboom TJ, Repping S, van der Veen F, Mol BWJ, Ravelli ACJ, Risk of poor neonatal outcome at term after medically assisted reproduction: a propensity score-matched study. FERTIL STERIL 2015;104 (2):384-90.e1 [PubMed]
Grooten IJ, Painter RC, Pontesilli M, van der Post JAM, Mol BWJ, van Eijsden M, Vrijkotte TGM, Roseboom TJ, Weight loss in pregnancy and cardiometabolic profile in childhood: findings from a longitudinal birth cohort. BJOG-INT J OBSTET GY 2015;122 (12):1664-1673 [PubMed]
Grooten IJ, Roseboom TJ, Painter RC, Barriers and Challenges in Hyperemesis Gravidarum Research. NUTR METAB INSIGHTS 2015;8 (1):33-39 [PubMed]
Grooten IJ, Vinke ME, Roseboom TJ, Painter RC, A Systematic Review and Meta-Analysis of the Utility of Corticosteroids in the Treatment of Hyperemesis Gravidarum. NUTR METAB INSIGHTS 2015;8 (1):23-32 [PubMed]
Kuiper DB, Seggers J, Schendelaar P, Haadsma ML, Roseboom TJ, Heineman MJ, Hadders-Algra M, Asthma and asthma medication use among 4-year-old offspring of subfertile couples--association with IVF?. REPROD BIOMED ONLINE 2015;31 (5):711-714 [PubMed]
Pontesilli M, Painter RC, Grooten IJ, van der Post JA, Mol BW, Vrijkotte TGM, Repping S, Roseboom TJ, Subfertility and assisted reproduction techniques are associated with poorer cardiometabolic profiles in childhood. REPROD BIOMED ONLINE 2015;30 (3):258-267 [PubMed]
de Rooij SR, Roseboom TJ, Painter RC, Famines in the last 100 years: implications for diabetes. CURR DIABETES REP 2014;14 (10):536 [PubMed]
Gademan MGJ, Twickler TB, Roseboom TJ, Vrijkotte TGM, Maternal lipid profile during early pregnancy and their children's blood pressure and cardiac autonomic balance at age 5-6 years. INT J CARDIOL 2014;176 (3):1003-1005 [PubMed]
Gademan MGJ, Vermeulen M, Oostvogels AJJM, Roseboom TJ, Visscher TLS, van Eijsden M, Twickler MTB, Vrijkotte TGM, Maternal prepregancy BMI and lipid profile during early pregnancy are independently associated with offspring's body composition at age 5-6 years: the ABCD study. PLOS ONE 2014;9 (4):e94594 [PubMed]
Ginty AT, Jones A, Carroll D, Roseboom TJ, Phillips AC, Painter R, de Rooij SR, Neuroendocrine and cardiovascular reactions to acute psychological stress are attenuated in smokers. PSYCHONEUROENDOCRINO 2014;48:87-97 [PubMed]
Kleijkers SHM, van Montfoort APA, Smits LJM, Viechtbauer W, Roseboom TJ, Nelissen ECM, Coonen E, Derhaag JG, Bastings L, Schreurs IEL, Evers JLH, Dumoulin JCM, IVF culture medium affects post-natal weight in humans during the first 2 years of life. HUM REPROD 2014;29 (4):661-669 [PubMed]
La Bastide-van Gemert S, Seggers J, Haadsma ML, Heineman MJ, Middelburg KJ, Roseboom TJ, Schendelaar P, Hadders-Algra M, van den Heuvel ER, Is ovarian hyperstimulation associated with higher blood pressure in 4-year-old IVF offspring? Part II: an explorative causal inference approach. HUM REPROD 2014;29 (3):510-517 [PubMed]
Niemeijer MN, Grooten IJ, Vos N, Bais JMJ, van der Post JA, Mol BW, Roseboom TJ, Leeflang MMG, Painter RC, Diagnostic markers for hyperemesis gravidarum: a systematic review and metaanalysis. AM J OBSTET GYNECOL 2014;211 (2):150.e1-150.15 [PubMed]
Oostvogels AJJM, Stronks K, Roseboom TJ, van der Post JAM, van Eijsden M, Vrijkotte TGM, Maternal prepregnancy BMI, offspring's early postnatal growth, and metabolic profile at age 5-6 years: the ABCD Study. J CLIN ENDOCR METAB 2014;99 (10):3845-3854 [PubMed]
Roseboom TJ, Painter R. Epidemiology of Transgenerational Epigenetics in: Tollefsbol T, editor. Transgenerational epigenetics. S.l.: Elsevier; 2014., p. 59-66
Roseboom T, Painter R. Transgenerational Impact of Nutrition on Disease Risk in: N. N, editor. Encyclopedia of life sciences (eLS). Chichester: John Wiley & Sons Ltd; 2005. 2014, p. a0025445
Savitri AI, Yadegari N, Bakker J, van Ewijk RJG, Grobbee DE, Painter RC, Uiterwaal CSPM, Roseboom TJ, Ramadan fasting and newborn's birth weight in pregnant Muslim women in The Netherlands. BRIT J NUTR 2014;112 (9):1503-1509 [PubMed]
Seggers J, Haadsma ML, La Bastide-van Gemert S, Heineman MJ, Middelburg KJ, Roseboom TJ, Schendelaar P, van den Heuvel ER, Hadders-Algra M, Is ovarian hyperstimulation associated with higher blood pressure in 4-year-old IVF offspring? Part I: multivariable regression analysis. HUM REPROD 2014;29 (3):502-509 [PubMed]
Belva F, Painter RC, Schiettecatte J, Bonduelle M, Roelants M, Roseboom TJ, Tournaye H, de Schepper J, Gender-specific alterations in salivary cortisol levels in pubertal intracytoplasmic sperm injection offspring. HORM RES PAEDIAT 2013;80 (5):350-355 [PubMed]
Bibbey A, Carroll D, Roseboom TJ, Phillips AC, de Rooij SR, Personality and physiological reactions to acute psychological stress. INT J PSYCHOPHYSIOL 2013;90 (1):28-36 [PubMed]
de Rooij SR, Roseboom TJ, The developmental origins of ageing: study protocol for the Dutch famine birth cohort study on ageing. BMJ OPEN 2013;3 (6):e003167 [PubMed]
de Rooij SR, van Eijsden M, Roseboom TJ, Vrijkotte TGM, Ethnic differences in childhood autonomic nervous system regulation. INT J CARDIOL 2013;168 (5):5064-5066 [PubMed]
Gabory A, Roseboom TJ, Moore T, Moore LG, Junien C, Placental contribution to the origins of sexual dimorphism in health and diseases: sex chromosomes and epigenetics. BIOL SEX DIFFER 2013;4 (1):5 [PubMed]
Gademan MGJ, van Eijsden M, Roseboom TJ, van der Post JAM, Stronks K, Vrijkotte TGM, Maternal prepregnancy body mass index and their children's blood pressure and resting cardiac autonomic balance at age 5 to 6 years. HYPERTENSION 2013;62 (3):641-647 [PubMed]
Ginty AT, Carroll D, Roseboom TJ, Phillips AC, de Rooij SR, Depression and anxiety are associated with a diagnosis of hypertension 5 years later in a cohort of late middle-aged men and women. J HUM HYPERTENS 2013;27 (3):187-190 [PubMed]
Idris NS, Uiterwaal CSPM, van der Schouw YT, van Abeelen AFM, Roseboom TJ, de Jong PA, Rutten A, Grobbee DE, Elias SG, Famine in childhood and postmenopausal coronary artery calcification: a cohort study. BMJ OPEN 2013;3 (11):e003818 [PubMed]
Seggers J, Haadsma ML, Bastide-van Gemert Sl, Heineman MJ, Kok JH, Middelburg KJ, Roseboom TJ, Schendelaar P, van den Heuvel ER, Hadders-Algra M, Blood pressure and anthropometrics of 4-y-old children born after preimplantation genetic screening: follow-up of a unique, moderately sized, randomized controlled trial. PEDIATR RES 2013;74 (5):606-614 [PubMed]
van Abeelen AFM, Elias SG, de Jong PA, Grobbee DE, Bossuyt PMM, van der Schouw YT, Roseboom TJ, Uiterwaal CSPM, Famine in the young and risk of later hospitalization for COPD and asthma. PLOS ONE 2013;8 (12):e82636 [PubMed]
van Ewijk RJG, Painter RC, Roseboom TJ, Associations of prenatal exposure to Ramadan with small stature and thinness in adulthood: results from a large Indonesian population-based study. AM J EPIDEMIOL 2013;177 (8):729-736 [PubMed]
van Ewijk RJG, Painter RC, Roseboom TJ, Associations of Prenatal Exposure to Ramadan With Small Stature and Thinness in Adulthood: Results From a Large Indonesian Population-Based Study : Editorial comment. OBSTET GYNECOL SURV 2013;68 (9):609-611
van Ewijk RJG, Painter RC, Roseboom TJ, Van Ewijk et al. respond to "Ramadan prenatal fasting and adult health outcomes". AM J EPIDEMIOL 2013;177 (8):741-742 [PubMed]
Veenendaal MVE, Painter RC, de Rooij SR, Bossuyt PMM, van der Post JAM, Gluckman PD, Hanson MA, Roseboom TJ, Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine. BJOG-INT J OBSTET GY 2013;120 (5):548-553 [PubMed]
Belva F, Roelants M, de Schepper J, Roseboom TJ, Bonduelle M, Devroey P, Painter RC, Blood pressure in ICSI-conceived adolescents. HUM REPROD 2012;27 (10):3100-3108 [PubMed]
Botden IPG, Zillikens MC, de Rooij SR, Langendonk JG, Danser AHJ, Sijbrands EJG, Roseboom TJ, Variants in the SIRT1 Gene May Affect Diabetes Risk in Interaction With Prenatal Exposure to Famine. DIABETES CARE 2012;35 (2):424-426 [PubMed]
Carroll D, Bibbey A, Roseboom TJ, Phillips AC, Ginty AT, de Rooij SR, Forced expiratory volume is associated with cardiovascular and cortisol reactions to acute psychological stress. PSYCHOPHYSIOLOGY 2012;49 (6):866-872 [PubMed]
Carroll D, Ginty AT, Painter RC, Roseboom TJ, Phillips AC, de Rooij SR, Systolic blood pressure reactions to acute stress are associated with future hypertension status in the Dutch Famine Birth Cohort Study. INT J PSYCHOPHYSIOL 2012;85 (2):270-273 [PubMed]
de Rooij SR, Costello PM, Veenendaal MVE, Lillycrop KA, Gluckman PD, Hanson MA, Painter RC, Roseboom TJ, Associations between DNA methylation of a glucocorticoid receptor promoter and acute stress responses in a large healthy adult population are largely explained by lifestyle and educational differences. PSYCHONEUROENDOCRINO 2012;37 (6):782-788 [PubMed]
de Rooij SR, Veenendaal MVE, Räikkönen K, Roseboom TJ, Personality and stress appraisal in adults prenatally exposed to the Dutch famine. EARLY HUM DEV 2012;88 (5):321-325 [PubMed]
Gahagan S, Uauy R, Roseboom TJ, Developmental origins of pediatric obesity. INT J PEDIATR 2012;2012:309863 [PubMed]
Ginty AT, Phillips AC, Roseboom TJ, Carroll D, Derooij SR, Cardiovascular and cortisol reactions to acute psychological stress and cognitive ability in the Dutch Famine Birth Cohort Study. PSYCHOPHYSIOLOGY 2012;49 (3):391-400 [PubMed]
Lussana F, de Rooij SR, Veenendaal M, Razzari C, Fontana G, Faioni EM, Painter RC, Middeldorp S, Cattaneo M, Roseboom TJ, Prevalence of factor V Leiden and G20210A prothrombin mutation in the Dutch Famine Birth Cohort: A possible survival advantage?. THROMB HAEMOSTASIS 2012;108 (2):399-401 [PubMed]
Painter RC, Roseboom TJ, de Rooij SR, Long-term effects of prenatal stress and glucocorticoid exposure. BIRTH DEFECTS RES C 2012;96 (4):315-324 [PubMed]
Phillips AC, Roseboom TJ, Carroll D, de Rooij SR, Cardiovascular and Cortisol Reactions to Acute Psychological Stress and Adiposity: Cross-Sectional and Prospective Associations in the Dutch Famine Birth Cohort Study. PSYCHOSOM MED 2012;74 (7):699-710 [PubMed]
Portella AK, Kajantie E, Hovi P, Desai M, Ross MG, Goldani MZ, Roseboom TJ, Silveira PP, Effects of in utero conditions on adult feeding preferences. J DEV ORIG HLTH DIS 2012;3 (3):140-152 [PubMed]
Räikkönen K, Pesonen AK, Roseboom TJ, Eriksson JG, Early determinants of mental health. BEST PRACT RES CL EN 2012;26 (5):599-611 [PubMed]
Roseboom TJ, Undernutrition during fetal life and the risk of cardiovascular disease in adulthood. FUTURE CARDIOL 2012;8 (1):5-7 [PubMed]
Roseboom TJ, Watson ED, The next generation of disease risk: Are the effects of prenatal nutrition transmitted across generations? Evidence from animal and human studies. PLACENTA 2012;33 (2):E40-E44 [PubMed]
Roseboom T, Painter R, de Rooij S. Prenatal Famine Exposure and Long-Term Consequences for Anthropometry and Adult Health in: Preedy VR, editor. Handbook of Anthropometry : Physical Measures of Human Form in Health and Disease. Berlin: Springer; 2012., p. 1021-`1032
Thangaratinam S, Rogozińska E, Jolly K, Glinkowski S, Duda W, Borowiack E, Roseboom T, Tomlinson J, Walczak J, Kunz R, Mol BW, Coomarasamy A, Khan KS, Interventions to reduce or prevent obesity in pregnant women: a systematic review. HEALTH TECHNOL ASSES 2012;16 (31):1-+ [PubMed]
Thangaratinam S, Rogozinska E, Jolly K, Glinkowski S, Roseboom T, Tomlinson JW, Kunz R, Mol BW, Coomarasamy A, Khan KS, Effects of interventions in pregnancy on maternal weight and obstetric outcomes: meta-analysis of randomised evidence. BMJ-BRIT MED J 2012;344:e2088 [PubMed]
van Abeelen AFM. Undernutrition and chronic disease: the 1944-1945 Dutch famine. s.l.: s.n.; 2012. 205p. ISBN 9789461912596 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Bossuyt PMM, Grobbee DE; copromotor(s): Roseboom TJ, Uiterwaal CSPM, Elias SG)
van Abeelen AFM, Elias SG, Bossuyt PMM, Grobbee DE, van der Schouw YT, Roseboom TJ, Uiterwaal CSPM, Cardiovascular consequences of famine in the young. EUR HEART J 2012;33 (4):538-545 [PubMed]
van Abeelen AFM, Elias SG, Bossuyt PMM, Grobbee DE, van der Schouw YT, Roseboom TJ, Uiterwaal CSPM, Famine Exposure in the Young and the Risk of Type 2 Diabetes in Adulthood. DIABETES 2012;61 (9):2255-2260 [PubMed]
van Abeelen AFM, Elias SG, Roseboom TJ, Bossuyt PMM, van der Schouw YT, Grobbee DE, Uiterwaal CSPM, Postnatal acute famine and risk of overweight: the dutch hungerwinter study. INT J PEDIATR 2012;2012:936509 [PubMed]
van Abeelen AFM, Veenendaal MVE, Painter RC, de Rooij SR, Dijkgraaf MGW, Bossuyt PMM, Elias SG, Grobbee DE, Uiterwaal CSPM, Roseboom TJ, Survival effects of prenatal famine exposure. AM J CLIN NUTR 2012;95 (1):179-183 [PubMed]
van Abeelen AFM, Veenendaal MVE, Painter RC, de Rooij SR, Thangaratinam S, van der Post JAM, Bossuyt PMM, Elias SG, Uiterwaal CSPM, Grobbee DE, Saade GR, Mol BWJ, Khan KS, Roseboom TJ, The fetal origins of hypertension: a systematic review and meta-analysis of the evidence from animal experiments of maternal undernutrition. J HYPERTENS 2012;30 (12):2255-2267 [PubMed]
Veenendaal MV, Costello PM, Lillycrop KA, de Rooij SR, van der Post JA, Bossuyt PM, Hanson MA, Painter RC, Roseboom TJ, Prenatal famine exposure, health in later life and promoter methylation of four candidate genes. J DEV ORIG HLTH DIS 2012;3 (6):450-457 [PubMed]
Veenendaal MVE. The fetal origins of adult disease, the evidence and mechanisms. s.l.: s.n.; 2012. 144p. ISBN 9789461914378 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Bossuyt PMM, van der Post JAM; copromotor(s): Roseboom TJ, Painter RC)
de Rooij SR, Painter RC, Phillips DI, Räikkönen K, Schene AH, Roseboom TJ, Self-reported depression and anxiety after prenatal famine exposure: mediation by cardio-metabolic pathology?. J DEV ORIG HLTH DIS 2011;2 (3):136-143 [PubMed]
Roseboom TJ, Painter RC, de Rooij SR, van Abeelen AFM, Veenendaal MVE, Osmond C, Barker DJP, Effects of famine on placental size and efficiency. PLACENTA 2011;32 (5):395-399 [PubMed]
Roseboom TJ, Painter RC, van Abeelen AFM, Veenendaal MVE, de Rooij SR, Hungry in the womb: what are the consequences? Lessons from the Dutch famine. MATURITAS 2011;70 (2):141-145 [PubMed]
Roseboom TJ, Ravelli ACJ, van der Post JA, Painter RC, Maternal characteristics largely explain poor pregnancy outcome after hyperemesis gravidarum. EUR J OBSTET GYN R B 2011;156 (1):56-59 [PubMed]
van Abeelen AFM, de Rooij SR, Osmond C, Painter RC, Veenendaal MVE, Bossuyt PMM, Elias SG, Grobbee DE, van der Schouw YT, Barker DJP, Roseboom TJ, The sex-specific effects of famine on the association between placental size and later hypertension. PLACENTA 2011;32 (9):694-698 [PubMed]
Veenendaal MVE, van Abeelen AFM, Painter RC, van der Post JAM, Roseboom TJ, Consequences of hyperemesis gravidarum for offspring: a systematic review and meta-analysis. BJOG-INT J OBSTET GY 2011;118 (11):1302-1313 [PubMed]
de Rooij SR, Roseboom TJ, Further evidence for an association between self-reported health and cardiovascular as well as cortisol reactions to acute psychological stress. PSYCHOPHYSIOLOGY 2010;47 (6):1172-1175 [PubMed]
de Rooij SR, Schene AH, Phillips DI, Roseboom TJ, Depression and anxiety: Associations with biological and perceived stress reactivity to a psychological stress protocol in a middle-aged population. PSYCHONEUROENDOCRINO 2010;35 (6):866-877 [PubMed]
de Rooij SR, Wouters H, Yonker JE, Painter RC, Roseboom TJ, Prenatal undernutrition and cognitive function in late adulthood. P NATL ACAD SCI USA 2010;107 (39):16881-16886 [PubMed]
Goedhart G, Vrijkotte TGM, Roseboom TJ, van der Wal MF, Cuijpers P, Bonsel GJ, Maternal cortisol and offspring birthweight: Results from a large prospective cohort study. PSYCHONEUROENDOCRINO 2010;35 (5):644-652 [PubMed]
Roseboom TJ, van de Krol R. Baby's van de hongerwinter. De onvermoede erfenis van ondervoeding. Amsterdam: Augustus; 2010. 221p. ISBN 9789045704197
van der Graaf A, Vissers MN, Gaudet D, Brisson D, Sivapalaratnam S, Roseboom TJ, Jansen ACM, Kastelein JJP, Hutten BA, Dyslipidemia of Mothers With Familial Hypercholesterolemia Deteriorates Lipids in Adult Offspring. ARTERIOSCL THROM VAS 2010;30 (12):2673-U623 [PubMed]
de Rooij SR, Painter RC, Swaab DF, Roseboom TJ, Sexual Orientation and Gender Identity After Prenatal Exposure to the Dutch Famine. ARCH SEX BEHAV 2009;38 (3):411-416 [PubMed]
Klooker TK, Braak B, Painter RC, de Rooij SR, van Elburg RM, van den Wijngaard RM, Roseboom TJ, Boeckxstaens GE, Exposure to Severe Wartime Conditions in Early Life Is Associated With an Increased Risk of Irritable Bowel Syndrome: A Population-Based Cohort Study. AM J GASTROENTEROL 2009;104 (9):2250-2256 [PubMed]
Mesman I, Roseboom TJ, Bonsel GJ, Gemke RJBJ, van der Wal MF, Vrijkotte TG, Maternal pre-pregnancy body mass index explains infant's weight and BMI at 14 months: results from a multi-ethnic birth cohort study. ARCH DIS CHILD 2009;94 (8):587-595 [PubMed]
Painter RC, Westendorp RGJ, de Rooij SR, Osmond C, Barker DJP, Roseboom TJ, Reply: Increased reproductive success of women after prenatal undernutrition?. HUM REPROD 2009;24 (2):491-492
Painter R, de Rooij S, Osmond C, Gluckman P, Hanson M, Phillips D, Roseboom T, Transgenerational effects of prenatal exposure to the Dutch famine Author's Reply. BJOG-INT J OBSTET GY 2009;116 (6):868
van Hoek M, Langendonk JG, de Rooij SR, Sijbrands EJG, Roseboom TJ, Genetic variant in the IGF2BP2 gene may interact with fetal malnutrition to affect glucose metabolism. DIABETES 2009;58 (6):1440-1444 [PubMed]
Lussana F, Painter RC, Ocke MC, Buller HR, Bossuyt PM, Roseboom TJ, Prenatal exposure to the Dutch famine is associated with a preference for fatty foods and a more atherogenic lipid profile. AM J CLIN NUTR 2008;88 (6):1648-1652 [PubMed]
Painter RC, Osmond C, Gluckman P, Hanson M, Phillips DIW, Roseboom TJ, Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life. BJOG-INT J OBSTET GY 2008;115 (10):1243-1249 [PubMed]
Painter RC, Westendorp RGJ, de Rooij SR, Osmond C, Barker DJP, Roseboom TJ, Increased reproductive success of women after prenatal undernutrition. HUM REPROD 2008;23 (11):2591-2595 [PubMed]
Roseboom TJ, Painter RC, de Rooij SR. The Dutch famine of 1944-45: prenatal exposure to undernutrition and longterm consequences for glucose and insuline metabolism. Kerala: Transworld Research Network; 2008. -p.
Whincup PH, Kaye SJ, Owen CG, Huxley R, Cook DG, Anazawa S, Barrett-Connor E, Bhargava SK, Birgisdottir BE, Carlsson S, de Rooij SR, Dyck RF, Eriksson JG, Falkner B, Fall C, Forsén T, Grill V, Gudnason V, Hulman S, Hyppönen E, Jeffreys M, Lawlor DA, Leon DA, Minami J, Mishra G, Osmond C, Power C, Rich-Edwards JW, Roseboom TJ, Sachdev HS, Syddall H, Thorsdottir I, Vanhala M, Wadsworth M, Yarbrough DE, Birth Weight and Risk of Type 2 Diabetes A Systematic Review. JAMA-J AM MED ASSOC 2008;300 (24):2886-2897 [PubMed]
de Rooij SR. Metabolic consequences of prenatal exposure to the Dutch famine. S.l.: s.n.; 2007. 125p. ISBN 9789090213705 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Bleker OP, Bossuyt PMM; copromotor(s): Roseboom TJ, Tanck MWT)
de Rooij SR, Painter RC, Holleman F, Bossuyt PMM, Roseboom TJ, The metabolic syndrome in adults prenatally exposed to the Dutch famine. AM J CLIN NUTR 2007;86 (4):1219-1224 [PubMed]
Painter RC, de Rooij SR, Bossuyt PM, de Groot E, Stok WJ, Osmond C, Barker DJ, Bleker OP, Roseboom TJ, Maternal nutrition during gestation and carotid arterial compliance in the adult offspring: the Dutch famine birth cohort. J HYPERTENS 2007;25 (3):533-540 [PubMed]
Painter RC, de Rooij SR, Hutten BA, Bossuyt PMM, de Groot E, Osmond C, Barker DJP, Bleker OP, Roseboom TJ, Reduced intima media thickness in adults after prenatal exposure to the Dutch famine. ATHEROSCLEROSIS 2007;193 (2):421-427 [PubMed]
Painter RC, Roseboom TJ, Cardiovascular health among children born after assisted reproduction. EUR J OBSTET GYN R B 2007;131 (1):107-8; author reply 109 [PubMed]
de Rooij SR, Painter RC, Phillips DIW, Osmond C, Michels RPJ, Bossuyt PMM, Bleker OP, Roseboom TJ, Hypothalamic-pituitary-adrenal axis activity in adults who were prenatally exposed to the Dutch famine. EUR J ENDOCRINOL 2006;155 (1):153-160 [PubMed]
de Rooij SR, Painter RC, Phillips DIW, Osmond C, Michels RPJ, Godsland IF, Bossuyt PMM, Bleker OP, Roseboom TJ, Impaired insulin secretion after prenatal exposure to the Dutch famine. DIABETES CARE 2006;29 (8):1897-1901 [PubMed]
de Rooij SR, Painter RC, Phillips DIW, Osmond C, Tanck MWT, Bossuyt PMM, Roseboom TJ, Cortisol responses to psychological stress in adults after prenatal exposure to the Dutch famine. PSYCHONEUROENDOCRINO 2006;31 (10):1257-1265 [PubMed]
de Rooij SR, Painter RC, Phillips DIW, Osmond C, Tanck MWT, Defesche JC, Bossuyt PMM, Michels RPJ, Bleker OP, Roseboom TJ, The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on glucose/insulin metabolism interact with prenatal exposure to famine. DIABETES CARE 2006;29 (5):1052-1057 [PubMed]
de Rooij SR, Painter RC, Roseboom TJ, Phillips DIW, Osmond C, Barker DJP, Tanck MW, Michels RPJ, Bossuyt PMM, Bleker OP, Glucose tolerance at age 58 and the decline of glucose tolerance in comparison with age 50 in people prenatally exposed to the Dutch famine. DIABETOLOGIA 2006;49 (4):637-643 [PubMed]
Painter RC. The pathophysiology of cardiovascular disease after prenatal exposure to maternal undernutrition during Dutcxh famine. S.l.: s.n.; 2006. 147p. ISBN 9789090210193 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Bleker OP, Bossuyt PMM; copromotor(s): Roseboom TJ)
Painter RC, de Rooij SR, Bossuyt PMM, Osmond C, Barker DJP, Bleker OP, Roseboom TJ, A possible link between prenatal exposure to famine and breast cancer: a preliminary study. AM J HUM BIOL 2006;18 (6):853-856 [PubMed]
Painter RC, de Rooij SR, Bossuyt PM, Phillips DI, Osmond C, Barker DJ, Bleker OP, Roseboom TJ, Blood pressure response to psychological stressors in adults after prenatal exposure to the Dutch famine. J HYPERTENS 2006;24 (9):1771-1778 [PubMed]
Painter RC, de Rooij SR, Bossuyt PM, Simmers TA, Osmond C, Barker DJ, Bleker OP, Roseboom TJ, Early onset of coronary artery disease after prenatal exposure to the Dutch famine. AM J CLIN NUTR 2006;84 (2):322-7; quiz 466-7 [PubMed]
Painter RC, Roseboom TJ, Preconceptiezorg: een onlosmakelijk onderdeel van de zorg voor moeder en kind. NED TIJDSCHR GENEESKD 2006;150 (40):2221-2222 [PubMed]
Roseboom T, de Rooij S, Painter R, The Dutch famine and its long-term consequences for adult health. EARLY HUM DEV 2006;82 (8):485-491 [PubMed]
Painter RC, Roseboom TJ, Bleker OP, Prenatal exposure to the Dutch famine and disease in later life: An overview. REPROD TOXICOL 2005;20 (3):345-352 [PubMed]
Painter RC, Roseboom TJ, Bossuyt PMM, Osmond C, Barker DJP, Bleker OP, Adult mortality at age 57 after prenatal exposure to the Dutch famine. EUR J EPIDEMIOL 2005;20 (8):673-676 [PubMed]
Painter RC, Roseboom TJ, van Montfrans GA, Bossuyt PMM, Krediet RT, Osmond C, Barker DJP, Bleker OP, Microalbuminuria in adults after prenatal exposure to the Dutch famine. J AM SOC NEPHROL 2005;16 (1):189-194 [PubMed]
Ravelli ACJ, Bleker OP, Roseboom TJ, van Montfrans GA, Osmond C, Barker DJP, Cardiovascular disease in survivors of the Dutch famine. NESTLE NUTR WORKSHOP SER PEDIATR PROGRAM 2005;55:183-191 [PubMed]
Roseboom T, Commentary: Maternal diet during pregnancy and blood pressure in the offspring. INT J EPIDEMIOL 2005;34 (2):385-386 [PubMed]
Roseboom TJ, van der Meulen JHP, Ravelli ACJ, Osmond C, Barker DJP, Bleker OP, Perceived health of adults after prenatal exposure to the Dutch famine. PAEDIATR PERINAT EP 2003;17 (4):391-397 [PubMed]
Rhemrev JP, Menkveld R, Roseboom TJ, van Overveld FW, Teerlink T, Lombard C, Vermeiden JP, The acrosome index, radical buffer capacity and number of isolated progressively motile spermatozoa predict IVF results. HUM REPROD 2001;16 (9):1885-1892 [PubMed]
Roseboom TJ, The fetal origins hypothesis. TWIN RES 2001;4 (5):iii [PubMed]
Roseboom TJ, van der Meulen JH, Osmond C, Barker DJ, Ravelli AC, Bleker OP, Adult survival after prenatal exposure to the Dutch famine 1944--45. PAEDIATR PERINAT EP 2001;15 (3):220-225 [PubMed]
Roseboom TJ, van der Meulen JH, Ravelli AC, Osmond C, Barker DJ, Bleker OP, Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview. TWIN RES 2001;4 (5):293-298 [PubMed]
Roseboom TJ, van der Meulen JH, Ravelli AC, Osmond C, Barker DJ, Bleker OP, Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview. MOL CELL ENDOCRINOL 2001;185 (1-2):93-98 [PubMed]
Roseboom TJ, van der Meulen JH, van Montfrans GA, Ravelli AC, Osmond C, Barker DJ, Bleker OP, Maternal nutrition during gestation and blood pressure in later life. J HYPERTENS 2001;19 (1):29-34 [PubMed]
Lopuhaä CE, Roseboom TJ, Osmond C, Barker DJ, Ravelli AC, Bleker OP, van der Zee JS, van der Meulen JH, Atopy, lung function, and obstructive airways disease after prenatal exposure to famine. THORAX 2000;55 (7):555-561 [PubMed]
Roseboom TJ, van der Meulen JH, Osmond C, Barker DJ, Ravelli AC, Bleker OP, Plasma lipid profiles in adults after prenatal exposure to the Dutch famine. AM J CLIN NUTR 2000;72 (5):1101-1106 [PubMed]
Roseboom TJ, van der Meulen JH, Osmond C, Barker DJ, Ravelli AC, Schroeder-Tanka JM, van Montfrans GA, Michels RP, Bleker OP, Coronary heart disease after prenatal exposure to the Dutch famine, 1944-45. HEART 2000;84 (6):595-598 [PubMed]
Roseboom TJ, van der Meulen JH, Ravelli AC, Bleker OP, De samenhang tussen prenatale blootstelling aan de Hongerwinter en medische bevindingen op lange termijn. NED TIJDSCHR GENEESKD 2000;144 (52):2488-2491 [PubMed]
Roseboom TJ, van der Meulen JH, Ravelli AC, Osmond C, Barker DJ, Bleker OP, Plasma fibrinogen and factor VII concentrations in adults after prenatal exposure to famine. BRIT J HAEMATOL 2000;111 (1):112-117 [PubMed]
Roseboom TJ, van der Meulen JH, Ravelli AC, van Montfrans GA, Osmond C, Barker DJ, Bleker OP, Blood pressure in adults after prenatal exposure to famine. J HYPERTENS 1999;17 (3):325-330 [PubMed]
Vermeiden JP, Roseboom TJ, Goverde AJ, Suchartwatnachai C, Schoute E, Braat DD, Schats R, An artificially induced follicle stimulating hormone surge at the time of human chorionic gonadotrophin administration in controlled ovarian stimulation cycles has no effect on cumulus expansion, fertilization rate, embryo quality and implantation rate. HUM REPROD 1997;12 (7):1399-1402 [PubMed]
Roseboom TJ, Vermeiden JP, Schoute E, Lens JW, Schats R, The probability of pregnancy after embryo transfer is affected by the age of the patient, cause of infertility, number of embryos transferred and the average morphology score, as revealed by multiple logistic regression analysis. HUM REPROD 1995;10 (11):3035-3041 [PubMed]
Key publications

de Rooij SR, Caan MWA, Swaab DF, Nederveen AJ, Majoie CB, Schwab M, Painter RC, Roseboom TJ, Prenatal famine exposure has sex-specific effects on brain size. BRAIN 2016;139 (Part 8):2136-2142 [PubMed]
van Ewijk RJG, Painter RC, Roseboom TJ, Associations of prenatal exposure to Ramadan with small stature and thinness in adulthood: results from a large Indonesian population-based study. AM J EPIDEMIOL 2013;177 (8):729-736 [PubMed]
Botden IPG, Zillikens MC, de Rooij SR, Langendonk JG, Danser AHJ, Sijbrands EJG, Roseboom TJ, Variants in the SIRT1 Gene May Affect Diabetes Risk in Interaction With Prenatal Exposure to Famine. DIABETES CARE 2012;35 (2):424-426 [PubMed]
de Rooij SR, van Pelt AMM, Ozanne SE, Korver CM, van Daalen SKM, Painter RC, Schwab M, Viegas MH, Roseboom TJ, Prenatal undernutrition and leukocyte telomere length in late adulthood: the Dutch famine birth cohort study. AM J CLIN NUTR 2015;102 (3):655-660 [PubMed]
Grooten IJ, Painter RC, Pontesilli M, van der Post JAM, Mol BWJ, van Eijsden M, Vrijkotte TGM, Roseboom TJ, Weight loss in pregnancy and cardiometabolic profile in childhood: findings from a longitudinal birth cohort. BJOG-INT J OBSTET GY 2015;122 (12):1664-1673 [PubMed]


All Publications

Research programmes

Early Development and Health

A person’s experience as a fetus affects his or her health throughout life. During the past twenty years we have studied the effects of undernutrition during gestation in a group of people born around the time of the Dutch famine. This provided the first direct evidence in humans that undernutrition during gestation increases the risk of many diseases that plague our society, such as heart disease, diabetes, airways disease, obesity, renal disease and cancer. By studying the differential effects of exposure during various stages of prenatal development, we have been able to pinpoint the first trimester as an especially vulnerable period of development for subsequent disease. Therefore research now focusses on long-term consequences of environmental changes in this period, such as those occurring in hyperemesis gravidarum (severe morning sickness) and assisted reproduction techniques as well as interventions before and during pregnancy on child growth, development and health.The ultimate aim it to learn more about how to give every child a good start in life to improve the health and wellbeing of future generations.

Theme: Public Health

Faculty
Prof. dr. T.J. Roseboom PhD
Dr. R.C. Painter MD PhD

Postdocs
Dr. C. van de Beek PhD
A.W. van Deutekom MD MSc
S.R. de Rooij PhD
Dr. A.J.G. Wirix

PhD Students
L.S. Bleker
M. Botter
Drs. L. van Dammen
C.R. Dean
Drs. T. van Elten
Ir. M.D.A. Karsten
M.H. Koot
Drs. M.D. Menting
S. Mintjens MD MSc (VUmc)
Drs. M. Pontesilli
A.A. de Ruigh
V. Wekker MD

Others
H. Bosch
Drs. A.J. Oostvogels MSc
Drs. A.M. Teitsma-Jansen

Prof. dr. J.A.M. van der Post MD PhD (Reproductive Health, placental disease and maternal and fetal diseases)

Other research related activities
  • Membership of medical or scientific committee, Society of Developmental Origins of Health and Disease, Europe Representative
  • Membership of advisory board / Consultant, Moore Institute for Nutrition and Wellness, Portland Oregon
Current research funding
  • AMC
  • Brain & Behavior Research Foundation
  • Europese Unie
  • Medical Research BV
  • Nederlandse Hartstichting
  • Secretariat Nutricia Research Foundation
  • Universiteit van Amsterdam-ABC
  • ZonMw