• Female

Prof. dr. E.M. Derks

Position: Professor
Main activities: Research
Specialisation: Genetics in Psychiatry
foto
Focus of research:

Dr E.M. Derks (1975) has been named Professor by Special Appointment of Genetics in Psychiatry at the University of Amsterdam’s (AMC-UvA) Faculty of Medicine. The chair was designated on behalf of the Foundation Volksbond Rotterdam (Stichting Volksbond Rotterdam).


Eske Derks investigates the role of genetic factors in psychiatric conditions, including addiction, anxiety disorders, compulsive disorders and schizophrenia. She is interested in the wide variety of symptoms typical of patients with a psychiatric condition. Derks pays particularly close attention to the development of new statistical methods aimed at discovering associations between genetic variants and psychiatric conditions. The ultimate aim of her research is to fully identify the biological processes that result in a psychiatric condition, starting with the genetic mutation and ending with the psychiatric diagnosis.


Derks has been a university lecturer at the Psychiatric Department of the Utrecht University Medical Center since 2007. Before coming to Utrecht, Derks obtained her doctorate degree cum laude from the VU University Amsterdam and worked for some time as a post-doctoral researcher at the Wellcome Trust Center of Human Genetics in Oxford, UK. From October 2010 to April 2011, Derks was a visiting scientist at the Queensland Institute of Medical Research in Brisbane, Australia. In 2008 she was awarded a Veni grant from the Netherlands Organisation for Scientific Research. Derks has published extensively in international journals including Molecular Psychiatry, Schizophrenia Bulletin and Journal of Clinical Psychiatry.
 

AMC themes: Neurological & Psychiatric Disorders
Departments: Psychiatry: Adult Psychiatry
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Luykx JJ, Bakker SC, Lentjes E, Neeleman M, Strengman E, Mentink L, DeYoung J, de Jong S, Sul JH, Eskin E, van Eijk K, van Setten J, Buizer-Voskamp JE, Cantor RM, Lu A, van Amerongen M, van Dongen EPA, Keijzers P, Kappen T, Borgdorff P, Bruins P, Derks EM, Kahn RS, Ophoff RA, Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. MOL PSYCHIATR 2014;19 (2):228-234 [PubMed]
Verweij KHW. Does family matter? The impact of family history on phenomenology and IQ in patients with schizophrenia and their relatives. s.l.: s.n.; 2014. -p. Proefschrift Utrecht University, Medicine. (Promotor(s): Kahn RS, Derks EM; copromotor(s): Cahn W)
Vleeschouwer M, Schubart CD, Henquet C, Myin-Germeys I, van Gastel WA, Hillegers MHJ, van Os JJ, Boks MPM, Derks EM, Does Assessment Type Matter? A Measurement Invariance Analysis of Online and Paper and Pencil Assessment of the Community Assessment of Psychic Experiences (CAPE). PLOS ONE 2014;9 (1):e84011 [PubMed]
Daalman K, Sommer IEC, Derks EM, Peters ER, Cognitive biases and auditory verbal hallucinations in healthy and clinical individuals. PSYCHOL MED 2013;43 (11):2339-2347 [PubMed]
Daalman K, Verkooijen S, Derks EM, Aleman A, Sommer IEC, The influence of semantic top-down processing in auditory verbal hallucinations (vol 139, pg 82, 2012). SCHIZOPHR RES 2013;143 (2-3):403
Davis LK, Yu D, Keenan CL, Gamazon ER, Konkashbaev AI, Derks EM, Neale BM, Yang J, Lee SH, Evans P, Barr CL, Bellodi L, Benarroch F, Berrio GB, Bienvenu OJ, Bloch MH, Blom RM, Bruun RD, Budman CL, Camarena B, Campbell D, Cappi C, Cardona Silgado JC, Cath DC, Cavallini MC, Chavira DA, Chouinard S, Conti DV, Cook EH, Coric V, Cullen BA, Deforce D, Delorme R, Dion Y, Edlund CK, Egberts K, Falkai P, Fernandez TV, Gallagher PJ, Garrido H, Geller D, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Haddad S, Heiman GA, Hemmings SMJ, Hounie AG, Illmann C, Jankovic J, Jenike MA, Kennedy JL, King RA, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Macciardi F, McCracken JT, McGrath LM, Mesa Restrepo SC, Moessner R, Morgan J, Muller H, Murphy DL, Naarden AL, Ochoa WC, Ophoff RA, Osiecki L, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner TJ, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosàrio MC, Rosenberg D, Rouleau GA, Ruhrmann S, Ruiz-Linares A, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Valencia Duarte AV, Vallada H, van Nieuwerburgh F, Veenstra-Vanderweele J, Walitza S, Wang Y, Wendland JR, Westenberg HGM, Shugart YY, Miguel EC, McMahon W, Wagner M, Nicolini H, Posthuma D, Hanna GL, Heutink P, Denys D, Arnold PD, Oostra BA, Nestadt G, Freimer NB, Pauls DL, Wray NR, Stewart SE, Mathews CA, Knowles JA, Cox NJ, Scharf JM, Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture. PLOS GENET 2013;9 (10):e1003864 [PubMed]
Derks EM, Ayub M, Chambert K, del Favero J, Johnstone M, Macgregor S, Maclean A, McKechanie AG, McRae AF, Moran JL, Pickard BS, Purcell S, Sklar P, Stclair DM, Wray NR, Visscher PM, Blackwood DHR, A Genome Wide Survey Supports the Involvement of Large Copy Number Variants in Schizophrenia With and Without Intellectual Disability. AM J MED GENET B 2013;162 (8):847-854 [PubMed]
Derks EM, Ophoff RA [Contributors: Kahn RS, Linszen D, van Os J, Wiersma D, Bruggeman R, Cahn W, de Haan L, Krabbendam L, Myin-Germeys I]] , Replication and refinement of the role of rs548181 in schizophrenia: results from a family based study. AM J MED GENET B 2013;162B (1):75-77 [PubMed]
Derks EM, van den Brink W, Verslaving en erfelijkheid. VERSLAVING 2013;9 (2):70-72
Heering HD, van Haren NEM, Derks EM [Contributors: Bruggeman R, Cahn W, de Haan L, Kahn RS, Meijer C, Myin-Germeys I, van Os J, Wiersma D]] , A two-factor structure of first rank symptoms in patients with a psychotic disorder. SCHIZOPHR RES 2013;147 (2-3):269-274 [PubMed]
Spanagel R, Durstewitz D, Hansson A, Heinz A, Kiefer F, Köhr G, Matthäus F, Nöthen MM, Noori HR, Obermayer K, Rietschel M, Schloss P, Scholz H, Schumann G, Smolka M, Sommer W, Vengeliene V, Walter H, Wurst W, Zimmermann US, Stringer S, Smits Y, Derks EM, A systems medicine research approach for studying alcohol addiction. ADDICT BIOL 2013;18 (6):883-896 [PubMed]
Stringer S, Derks EM, Kahn RS, Hill WG, Wray NR, Assumptions and properties of limiting pathway models for analysis of epistasis in complex traits. PLOS ONE 2013;8 (7):e68913 [PubMed]
Terwisscha van Scheltinga AF, Bakker SC, van Haren NEM, Derks EM, Buizer-Voskamp JE, Boos HBM, Cahn W, Hulshoff Pol HE, Ripke S, Ophoff RA, Kahn RS, Genetic Schizophrenia Risk Variants Jointly Modulate Total Brain and White Matter Volume. BIOL PSYCHIAT 2013;73 (6):525-531 [PubMed]
van den Berg SM, Paap MCS, Derks EM [Contributors: Kahn RS, Linszen DH, van Os J, Wiersma D, Bruggeman R, Cahn W, Haan L, Krabbendam L, Myin-Germeys I]] , Using multidimensional modeling to combine self-report symptoms with clinical judgment of schizotypy. PSYCHIAT RES 2013;206 (1):75-80 [PubMed]
van Scheltinga AFT, Bakker SC, van Haren NEM, Derks EM, Buizer-Voskamp JE, Cahn W, Ripke S, Ophoff RA, Kahn RS, Schizophrenia genetic variants are not associated with intelligence. PSYCHOL MED 2013;43 (12):2563-2570 [PubMed]
van Welie H, Derks EM, Verweij KH, de Valk HW, Kahn RS, Cahn W, The prevalence of diabetes mellitus is increased in relatives of patients with a non-affective psychotic disorder. SCHIZOPHR RES 2013;143 (2-3):354-357 [PubMed]
Velthorst E, Derks EM, Schothorst P, Becker H, Durston S, Ziermans T, Nieman DH, de Haan L, Quantitative and qualitative symptomatic differences in individuals at Ultra-High Risk for psychosis and healthy controls. PSYCHIAT RES 2013;210 (2):432-437 [PubMed]
Verweij KHW, Derks EM [Contributors: Kahn RS, Linszen D, van Os J, Wiersma D, Bruggeman R, Cahn W, de Haan L, Krabbendam L, Myin-Germeys I]] , The Association between Intelligence Scores and Family History of Psychiatric Disorder in Schizophrenia Patients, Their Siblings and Healthy Controls. PLOS ONE 2013;8 (10):e77215 [PubMed]
Vorstman JAS, Anney RJL, Derks EM, Gallagher L, Gill M, de Jonge MV, van Engeland H, Kahn RS, Ophoff RA, No evidence that common genetic risk variation is shared between schizophrenia and autism. AM J MED GENET B 2013;162B (1):55-60 [PubMed]
Boos HBM, Cahn W, van Haren NEM, Derks EM, Brouwer RM, Schnack HG, Hulshoff Pol HE, Kahn RS, Focal and global brain measurements in siblings of patients with schizophrenia. SCHIZOPHRENIA BULL 2012;38 (4):814-825 [PubMed]
Collin G, Derks EM, van Haren NEM, Schnack HG, Hulshoff Pol HE, Kahn RS, Cahn W, Symptom dimensions are associated with progressive brain volume changes in schizophrenia. SCHIZOPHR RES 2012;138 (2-3):171-176 [PubMed]
Daalman K, Verkooijen S, Derks EM, Aleman A, Sommer IEC, The influence of semantic top-down processing in auditory verbal hallucinations. SCHIZOPHR RES 2012;139 (1-3):82-86 [PubMed]
Derks EM, Allardyce J, Boks MP, Vermunt JK, Hijman R, Ophoff RA [Contributors: Kahn RS, Linszen DH, van Os J, Wiersma D, Bruggeman R, Cahn W, de Haan L, Krabbendam L, Myin-Germeys I]] , Kraepelin was right: a latent class analysis of symptom dimensions in patients and controls. SCHIZOPHRENIA BULL 2012;38 (3):495-505 [PubMed]
Derks EM, Boks MPM, Vermunt JK [Contributors: Kahn RS, Linszen DH, van Os J, Wiersma D, Bruggeman R, Cahn W, de Haan L, Krabbendam L, Myin-Germeys I]] , The identification of family subtype based on the assessment of subclinical levels of psychosis in relatives. BMC PSYCHIATRY 2012;12:71 [PubMed]
Derks EM, Vorstman JAS, Ripke S, Kahn RS, Ophoff RA [Contributors: O'Donovan MC, Craddock N, Holmans PA, Hamshere M, Williams HJ, Moskvina V, Dwyer S, Georgieva L, Zammit S, Owen MJ, Sullivan PF, Lin DY, van den Oord E, Kim Y, Stroup TS, Lieberman JA, St Clair D, Kirov GK, Nikolov I, Toncheva D, Milanova V, Morris DW, O'Dushlaine CT, Kenny E, Quinn EM, Gill M, Corvin A, Blackwood DHR, McGhee KA, Pickard B, Malloy P, Maclean AW, McIntosh A, McQuillin A, Choudhury K, Datta S, Pimm J, Thirumalai S, Puri V, Krasucki R, Lawrence J, Quested D, Bass N, Gurling H, Pato MT, Pato CN, Fanous A, Hultman CM, Lichtenstein P, Bergen SE, Purcell S, Scolnick E, Sklar P, Gejman PV, Sanders AR, Duan J, Levinson DF, Shi J, Buccola NG, Mowry BJ, Freedman R, Amin F, Black DW, Black DW, Silverman JM, Byerley WF, Cloninger CR, Cichon S, Rietschel M, Nöthen MM, Maier W, Schulze TG, Mattheisen M, Hansen T, Olsen L, Jakobsen KD, Schmock H, Skjødt C, Rosengren A, Høffding LKE, Thygersen JH, Vangkilde A, Werge T, Giegling I, Hartmann AM, Konnerth H, Friedl M, Konte B, Muglia P, Rujescu D, Djurovic S, Mattingsdal M, Agartz I, Melle I, Andreassen OA, Ophoff RA, Cantor RM, Freimer NB, Kahn RS, Linszen DH, van Os J, Wiersma D, Bruggeman R, Cahn W, de Haan L, Krabbendam L, Myin-Germeys I, Strengman E, Malhotra AK, Lencz T, Ripke S, Daly MJ, Dudbridge F, Neale BM, Rossin L, Visscher PM, Posthuma D, Ruderfer DM, Kendler KS]] , Investigation of the Genetic Association between Quantitative Measures of Psychosis and Schizophrenia: A Polygenic Risk Score Analysis. PLOS ONE 2012;7 (6):e37852 [PubMed]
Fleischhacker WW, Derks E, Kahn RS, Interpreting treatment trials in schizophrenia patients: Lessons learned from EUFEST. SCHIZOPHR RES 2012;138 (1):39-40 [PubMed]
Gladwin TE, Derks EM, Rietschel M, Mattheisen M, Breuer R, Schulze TG, Nöthen MM, Levinson D, Shi J, Gejman PV, Cichon S, Ophoff RA [Contributors: Kahn RS, Linszen D, van Os J, Wiersma D, Bruggeman R, Cahn W, de Haan L, Krabbendam L, Myin-Germeys I]] , Segment-Wise Genome-Wide Association Analysis Identifies a Candidate Region Associated with Schizophrenia in Three Independent Samples. PLOS ONE 2012;7 (6):e38828 [PubMed]
Korver N, Quee PJ, Boos HBM, Simons CJP, de Haan L [Contributors: Kahn RS, Linszen DH, van Os J, Wiersma D, Bruggeman R, Cahn W, de Haan L, Krabbendam L, Myin-Germeys I, van den Berg SE, Schroeder CLA, van der Valk R, Dekker N, Meijer CJ, Korver N, Boyette LN, Meijer J, van Dam D, de Rijke I, Huinink S, de Vries RJ, Jansen M, Bos D, Hoen WP, te West EM, Groeneveld SHJ, Vergunst EM, Swets M, Vothknecht S, Poleacov I, van Dijk D, de Metz S, Hasty MT, Geertsa G, de Baaij PM, Metzger A, van Beveren NJM, Baldini M, Grimbergen FD, Boerma MAM, Agsteribbe C, Wisman HP, Monden MAH, Bosman MM, van Dijk M, Klaassen R, van der Tang T, Luteijn B, Winkel H, Weisz H, Strater ACP, Landman A, Vorstenbosch M, Op't Eijnde D, Lenders K, Loyen S, Roberts R, Sweers K, Gielen H, Soons N, Hintzen A, Habets V, Riské I, Vossen C, Martens E, Apers S, Wijnhoven L, Konings E, Lataster T, Lardinois M, Versmissen D, Simons C, van der Werf M, Habets P, Pfeiffer S, de Loore E, Heins M, Oorschot M, Meys M, Dietvorst M, van Zelst C, Crolla I, Mengelers R, van Goethem F, Beuken W, Byniam D, Driesen T, Marcelis M, Driessen G, Shazad A, van Winkel R, Henquet C, Kenis G, Delespaul P, Anema P, van Baaren EMJ, Bakker SC, Boos HBM, Caspers E, Derks EM, van Hemert S, Hemkes A, Hijman R, van Leeuwen M, Machielsen JEH, Ophoff RA, Rais M, Salden M, van Someren H, Strengman E, Vleesschouwer M, van Beek M, van Harten PN, Koning JPF, Schep W, Vollema MG, Prins P, Viester T, Akdeniz A, Verweij K, Kaymaz N, v d Heuvel F, v d Goot B, Hovens JE, Loonen AJM, Bous J, Veenstra M, van't Hag E, Quee PJ, Nienhuis FJ, Veermans E, Bartels AA, Duijndam F, Lugtenberg T, Knegtering H, Blaauw W, Wunderink A, Touw KP, Arends J, Slooff CJ, Brilman J, Schomaker M, van Wijk M, Wessels A, Vroom E, Meijerink K, Bogert I, Janssen W, de Berk H, Noorthoorn EO, Ising H, Blom JD, van der Gaag M, Mensen G, van der Snoek R, Smit R, Faber G]] , Genetic Risk and Outcome of Psychosis (GROUP), a multi site longitudinal cohort study focused on gene-environment interaction: objectives, sample characteristics, recruitment and assessment methods. INT J METH PSYCH RES 2012;21 (3):205-221 [PubMed]
Landolt K, Rössler W, Burns T, Ajdacic-Gross V, Galderisi S, Libiger J, Naber D, Derks EM, Kahn RS, Fleischhacker WW, The interrelation of needs and quality of life in first-episode schizophrenia. EUR ARCH PSY CLIN N 2012;262 (3):207-216 [PubMed]
Landolt K, Rössler W, Burns T, Ajdacic-Gross V, Galderisi S, Libiger J, Naber D, Derks EM, Kahn RS, Fleischhacker WW [Contributors: Kahn RS, Fleischhacker WW, Boter H, Keet IPM, Brugman C, Davidson M, Dollfus S, Gaebel W, Galderisi S, Gheorghe M, Gonen I, Grobbee DE, Hranov LG, Hummer M, Libiger J, Kra H, Lindefors N, López-Ibor JJ, Nijssen K, Peuskens J, Riecher-Rössler A, Rybakowski JK, Sedvall G, Wilmsdorff MV]] , Unmet needs in patients with first-episode schizophrenia: a longitudinal perspective. PSYCHOL MED 2012;42 (7):1461-1473 [PubMed]
Maat A, Fett AK, Derks E [Contributors: Kahn RS, Linszen DH, van Os J, Wiersma D, Bruggeman R, Cahn W, de Haan L, Krabbendam L, Myin-Germeys I]] , Social cognition and quality of life in schizophrenia. SCHIZOPHR RES 2012;137 (1-3):212-218 [PubMed]
Sommer IEC, Slotema CW, Daskalakis ZJ, Derks EM, Blom JD, van der Gaag M, The treatment of hallucinations in schizophrenia spectrum disorders. SCHIZOPHRENIA BULL 2012;38 (4):704-714 [PubMed]
Visscher PM, Goddard ME, Derks EM, Wray NR, Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses. MOL PSYCHIATR 2012;17 (5):474-485 [PubMed]
Korver-Nieberg N, Quee PJ, Boos HB, Simons CJ [Contributors: Kahn RS, Cahn W, Linszen DH, de Haan L, van Os J, Krabbendam L, Myin-Germeys I, Wiersma D, Bruggeman R, van den Berg SE, Schroeder CLA, van der Valk R, Dekker N, Meijer CJ, Korver N, Boyette LN, Meijer J, van Dam D, de Rijke I, Huinink S, de Vries RJ, Jansen M, Bos D, Hoen WP, te West EM, Groeneveld SHJ, Vergunst EM, Swets M, Vothknecht S, Poleacov I, van Dijk D, de Metz S, Hasty MT, Geertsa G, de Baaij PM, Metzger A, van Beveren NJM, Baldini M, Grimbergen FD, Boerma MAM, Agsteribbe C, Wisman HP, Monden MAH, Bosman MM, van Dijk M, Klaassen R, van der Tang T, Luteijn B, Winkel H, Weisz H, Strater ACP, Landman A, Vorstenbosch M, Op 't Eijnde D, Lenders K, Loyen S, Roberts R, Sweers K, Gielen H, Soons N, Hintzen A, Habets V, Risk é I, Vossen C, Martens E, Apers S, Wijnhoven L, Konings E, Lataster T, Lardinois M, Versmissen D, Simons C, van der Werf M, Habets P, Pfeifer S, de Loore E, Heins M, Oorschot M, Meys M, Dietvorst M, van Zelst C, Crolla I, Mengelers R, van Goethem F, Beuken W, Byniam D, Driesen T, Marcelis M, Driessen G, Shazad A, van Winkel R, Henquet C, Kenis G, Delespaul P, Anema P, van Baaren EMJ, Bakker SC, Boos HBM, Caspers E, Derks EM, van Hemert S, Hemkes A, Hijman R, van Leeuwen M, Machielsen JEH, Ophoff RA, Rais M, Salden M, van Someren H, Strengman E, Vleesschouwer M, van Beek M, van Harten PN, Koning JPF, Schep W, Vollema MG, Prins P, Viester T, Akdeniz A, Verweij K, Kaymaz N, v d Heuvel F, v d Goot B, Hovens JE, Loonen AJM, Bous J, Veenstra M, van 't Hag E, Quee PJ, Nienhuis FJ, Smid HGOM, Veermans E, Bartels AA, Duijndam F, Lugtenberg T, Knegtering H, Blaauw W, Wunderink A, Touw KP, Arends J, Slooff CJ, Brilman J, Schomaker M, van Wijk M, Wessels A, Vroom E, Meijerink K, Bogert I, Janssen W, de Berk H, Noorthoorn EO, Ising H, Blom JD, van der Gaag M, Mensen G, van der Snoek R, Smit R, Faber G]] , The validity of the DSM-IV diagnostic classification system of non-affective psychoses. AUST NZ J PSYCHIAT 2011;45 (12):1061-1068 [PubMed]
Stringer S, Wray NR, Kahn RS, Derks EM, Underestimated effect sizes in GWAS: fundamental limitations of single SNP analysis for dichotomous phenotypes. PLOS ONE 2011;6 (11):e27964 [PubMed]
Verweij KHW, Derks EM, Hendriks EJE, Cahn W, The influence of informant characteristics on the reliability of family history interviews. TWIN RES HUM GENET 2011;14 (3):217-220 [PubMed]
Volavka J, Czobor P, Derks EM, Bitter I, Libiger J, Kahn RS, Fleischhacker WW [Contributors: Kahn RS, Fleischhacker WW, Boter H, Keet IPM, Brugman C, Davidson M, Dollfus S, Gaebel W, Galderisi S, Gheorghe M, Gonen I, Grobbee DE, Hranov LG, Hummer M, Libiger J, Králové H, Lindefors N, López-Ibor JJ, Nijssen K, Peuskens J, Prelipceanu D, Riecher-Rössler A, Rybakowski JK, Sedvall G, von Wilmsdorff M]] , Efficacy of antipsychotic drugs against hostility in the European First-Episode Schizophrenia Trial (EUFEST). J CLIN PSYCHIAT 2011;72 (7):955-961 [PubMed]
Boks MPM, Derks EM, Dolan CV, Kahn RS, Ophoff RA, "Forward genetics" as a method to maximize power and cost-efficiency in studies of human complex traits. BEHAV GENET 2010;40 (4):564-571 [PubMed]
Boter H, Derks EM, Fleischhacker WW, Davidson M, Kahn RS [Contributors: Kahn RS, Fleischhacker WW, Boter H, Keet IPM, Brugman C, Davidson M, Dollfus S, Gaebel W, Galderisi S, Gheorghe M, Gonen I, Grobbee DE, Hranov LG, Hummer M, Libiger J, Libiger N, López-Ibor JJ, Nijssen K, Peuskens J, Prelipceanu D, Riecher-Rössler A, Rybakowski JK, Sedvall G, v Wilmsdorff M]] , Generalizability of the results of efficacy trials in first-episode schizophrenia: comparisons between subgroups of participants of the European First Episode Schizophrenia Trial (EUFEST). J CLIN PSYCHIAT 2010;71 (1):58-65 [PubMed]
Derks EM, Fleischhacker WW, Boter H, Peuskens J, Kahn RS [Contributors: Kahn RS, Fleischhacker WW, Boter H, Keet IPM, Brugman C, Davidson M, Dollfus S, Gaebel W, Galderisi S, Gheorghe M, Gonen I, Grobbee DE, Hranov LG, Hummer M, Libiger J, Lindefors N, López-Ibor JJ, Nijssen K, Peuskens J, Prelipceanu D, Riecher-Rössler A, Rybakowski JK, Sedvall G, v Wilmsdorff M]] , Antipsychotic drug treatment in first-episode psychosis: should patients be switched to a different antipsychotic drug after 2, 4, or 6 weeks of nonresponse?. J CLIN PSYCHOPHARM 2010;30 (2):176-180 [PubMed]
Gaebel W, Riesbeck M, von Wilmsdorff M, Burns T, Derks EM, Kahn RS, Rössler W, Fleischhacker WW [Contributors: Kahn RS, Fleischhacker WW, Boter H, Keet IPM, Brugman C, Davidson M, Dollfus S, Gaebel W, Galderisi J, Gheorghe M, Gonen I, Grobbee DE, Hranov LG, Hummer M, Libiger J, Lindefors N, López-Ibor JJ, Nijssen K, Peuskens J, Prelipceanu D, Riecher-Rössler A, Rybakowski JK, Sedvall G, Wilmsdorff Mv]] , Drug attitude as predictor for effectiveness in first-episode schizophrenia: Results of an open randomized trial (EUFEST). EUR NEUROPSYCHOPHARM 2010;20 (5):310-316 [PubMed]
Boks MP, Derks EM, Weisenberger DJ, Strengman E, Janson E, Sommer IE, Kahn RS, Ophoff RA, The relationship of DNA methylation with age, gender and genotype in twins and healthy controls. PLOS ONE 2009;4 (8):e6767 [PubMed]
Derks EM, Verweij KHW, Kahn RS, Cahn WC, The calculation of familial loading in schizophrenia. SCHIZOPHR RES 2009;111 (1-3):198-199 [PubMed]
Lubke GH, Hudziak JJ, Derks EM, van Bijsterveldt TCEM, Boomsma DI, Maternal ratings of attention problems in ADHD: evidence for the existence of a continuum. J AM ACAD CHILD PSY 2009;48 (11):1085-1093 [PubMed]
van 't Ent D, van Beijsterveldt CEM, Derks EM, Hudziak JJ, Veltman DJ, Todd RD, Boomsma DI, de Geus EJC, NEUROIMAGING OF RESPONSE INTERFERENCE IN TWINS CONCORDANT OR DISCORDANT FOR INATTENTION AND HYPERACTIVITY SYMPTOMS. NEUROSCIENCE 2009;164 (1):16-29 [PubMed]
Derks EM, Hudziak JJ, Dolan CV, van Beijsterveldt TCEM, Verhulst FC, Boomsma DI, Genetic and environmental influences on the relation between attention problems and attention deficit hyperactivity disorder. BEHAV GENET 2008;38 (1):11-23 [PubMed]
Poelen EAP, Derks EM, Engels RCME, van Leeuwe JFJ, Scholte RHJ, Willemsen G, Boomsma DI, The relative contribution of genes and environment to alcohol use in early adolescents: are similar factors related to initiation of alcohol use and frequency of drinking?. ALCOHOL CLIN EXP RES 2008;32 (6):975-982 [PubMed]
Bartels M, van Beijsterveldt CEM, Derks EM, Stroet TM, Polderman TJC, Hudziak JJ, Boomsma DI, Young Netherlands Twin Register (Y-NTR): a longitudinal multiple informant study of problem behavior. TWIN RES HUM GENET 2007;10 (1):3-11 [PubMed]
Derks EM, Dolan CV, Boomsma DI, Statistical power to detect genetic and environmental influences in the presence of data missing at random. TWIN RES HUM GENET 2007;10 (1):159-167 [PubMed]
Derks EM, Dolan CV, Hudziak JJ, Neale MC, Boomsma DI, Assessment and etiology of attention deficit hyperactivity disorder and oppositional defiant disorder in boys and girls. BEHAV GENET 2007;37 (4):559-566 [PubMed]
Derks EM, Hudziak JJ, Boomsma DI, Why more boys than girls with ADHD receive treatment: a study of Dutch twins. TWIN RES HUM GENET 2007;10 (5):765-770 [PubMed]
Lehn H, Derks EM, Hudziak JJ, Heutink P, van Beijsterveldt TCEM, Boomsma DI, Attention problems and attention-deficit/hyperactivity disorder in discordant and concordant monozygotic twins: evidence of environmental mediators. J AM ACAD CHILD PSY 2007;46 (1):83-91 [PubMed]
Polderman TJC, Derks EM, Hudziak JJ, Verhulst FC, Posthuma D, Boomsma DI, Across the continuum of attention skills: a twin study of the SWAN ADHD rating scale. J CHILD PSYCHOL PSYC 2007;48 (11):1080-1087 [PubMed]
van 't Ent D, Lehn H, Derks EM, Hudziak JJ, van Strien NM, Veltman DJ, de Geus EJC, Todd RD, Boomsma DI, A structural MRI study in monozygotic twins concordant or discordant for attention/hyperactivity problems: evidence for genetic and environmental heterogeneity in the developing brain. NEUROIMAGE 2007;35 (3):1004-1020 [PubMed]
Althoff RR, Copeland WE, Stanger C, Derks EM, Todd RD, Neuman RJ, van Beijsterveldt TCEM, Boomsma DI, Hudziak JJ, The latent class structure of ADHD is stable across informants. TWIN RES HUM GENET 2006;9 (4):507-522 [PubMed]
Boomsma DI, Rebollo I, Derks EM, van Beijsterveldt TCEM, Althoff RR, Rettew DC, Hudziak JJ, Longitudinal stability of the CBCL-juvenile bipolar disorder phenotype: A study in Dutch twins. BIOL PSYCHIAT 2006;60 (9):912-920 [PubMed]
Derks EM, Dolan CV, Boomsma DI, A test of the equal environment assumption (EEA) in multivariate twin studies. TWIN RES HUM GENET 2006;9 (3):403-411 [PubMed]
Derks EM, Hudziak JJ, Dolan CV, Ferdinand RF, Boomsma DI, The relations between DISC-IV DSM diagnoses of ADHD and multi-informant CBCL-AP syndrome scores. COMPR PSYCHIAT 2006;47 (2):116-122 [PubMed]
Derks EM, Hudziak JJ, van Beijsterveldt CEM, Dolan CV, Boomsma DI, Genetic analyses of maternal and teacher ratings on attention problems in 7-year-old Dutch twins. BEHAV GENET 2006;36 (6):833-844 [PubMed]
Hudziak JJ, Althoff RR, Derks EM, Faraone SV, Boomsma DI, Prevalence and genetic architecture of Child Behavior Checklist-juvenile bipolar disorder. BIOL PSYCHIAT 2005;58 (7):562-568 [PubMed]
Hudziak JJ, Derks EM, Althoff RR, Copeland W, Boomsma DI, The genetic and environmental contributions to oppositional defiant behavior: a multi-informant twin study. J AM ACAD CHILD PSY 2005;44 (9):907-914 [PubMed]
Hudziak JJ, Derks EM, Althoff RR, Rettew DC, Boomsma DI, The genetic and environmental contributions to attention deficit hyperactivity disorder as measured by the Conners' Rating Scales--Revised. AM J PSYCHIAT 2005;162 (9):1614-1620 [PubMed]
Derks EM, Dolan CV, Boomsma DI, Effects of censoring on parameter estimates and power in genetic modeling. TWIN RES 2004;7 (6):659-669 [PubMed]
Derks EM, Hudziak JJ, van Beijsterveldt CEM, Dolan CV, Boomsma DI, A study of genetic and environmental influences on maternal and paternal CBCL syndrome scores in a large sample of 3-year-old Dutch twins. BEHAV GENET 2004;34 (6):571-583 [PubMed]
Hudziak JJ, van Beijsterveldt CEM, Bartels M, Rietveld MJH, Rettew DC, Derks EM, Boomsma DI, Individual differences in aggression: genetic analyses by age, gender, and informant in 3-, 7-, and 10-year-old Dutch twins. BEHAV GENET 2003;33 (5):575-589 [PubMed]
Boomsma DI, Vink JM, van Beijsterveldt TCEM, de Geus EJC, Beem AL, Mulder EJCM, Derks EM, Riese H, Willemsen GAHM, Bartels M, van den Berg M, Kupper NHM, Polderman TJC, Posthuma D, Rietveld MJH, Stubbe JH, Knol LI, Stroet T, van Baal GCM, Netherlands Twin Register: a focus on longitudinal research. TWIN RES 2002;5 (5):401-406 [PubMed]
Key publications

Visscher PM, Goddard ME, Derks EM, Wray NR, Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses. MOL PSYCHIATR 2012;17 (5):474-485 [PubMed]
Stringer S, Wray NR, Kahn RS, Derks EM, Underestimated effect sizes in GWAS: fundamental limitations of single SNP analysis for dichotomous phenotypes. PLOS ONE 2011;6 (11):e27964 [PubMed]
Derks EM, Fleischhacker WW, Boter H, Peuskens J, Kahn RS [Contributors: Kahn RS, Fleischhacker WW, Boter H, Keet IPM, Brugman C, Davidson M, Dollfus S, Gaebel W, Galderisi S, Gheorghe M, Gonen I, Grobbee DE, Hranov LG, Hummer M, Libiger J, Lindefors N, López-Ibor JJ, Nijssen K, Peuskens J, Prelipceanu D, Riecher-Rössler A, Rybakowski JK, Sedvall G, v Wilmsdorff M]] , Antipsychotic drug treatment in first-episode psychosis: should patients be switched to a different antipsychotic drug after 2, 4, or 6 weeks of nonresponse?. J CLIN PSYCHOPHARM 2010;30 (2):176-180 [PubMed]
Derks EM, Allardyce J, Boks MP, Vermunt JK, Hijman R, Ophoff RA [Contributors: Kahn RS, Linszen DH, van Os J, Wiersma D, Bruggeman R, Cahn W, de Haan L, Krabbendam L, Myin-Germeys I]] , Kraepelin was right: a latent class analysis of symptom dimensions in patients and controls. SCHIZOPHRENIA BULL 2012;38 (3):495-505 [PubMed]
Boks MP, Derks EM, Weisenberger DJ, Strengman E, Janson E, Sommer IE, Kahn RS, Ophoff RA, The relationship of DNA methylation with age, gender and genotype in twins and healthy controls. PLOS ONE 2009;4 (8):e6767 [PubMed]


All Publications

Curriculum Vitae

EDUCATION

2001-2006:
PhD (cum laude), title thesis “Assessment and Genetic Aetiology of Attention Problems, Hyperactivity, and Related Disorders”, at the Free University, Department of Biological Psychology, Amsterdam.
Promotor: Prof. D.I. Boomsma
Co-promotors: Prof J.J. Hudziak, Dr. C.V. Dolan

1997-2001:
Bachelor and Master in Psychology at the University of Amsterdam, the Netherlands, with specializations in Statistical methods (cum laude) and neuroscience (cum laude)

WORK EXPERIENCE

January 2011 - present
Professor of Genetics in Psychiatry (0.88 fte, fixed term), Academic Medical Center, Amsterdam

November 2007 - December 2011
Senior Researcher (0.88 fte, tenure position), Department of Psychiatry, Utrecht Medical Center, Utrecht.
The main research projects in which I am involved are:
- “Improvement of phenotyping in Genome Wide Association studies on schizophrenia: an application of Latent Class Factor Analysis”. (funded by NWO; 250,000 Euro)
I am the prinicipal investigator of this project. The main goal of the current proposal is to improve the assessment of individual differences in schizophrenia, and to incorporate these improved phenotypic assessments in subsequent Genome Wide Association analyses.
- “Genetic Risk and Outcome in Psychosis (GROUP)”
This is a longitudinal study on gene-environment vulnerability and resilience in both clinical and non-clinical populations which offers the opportunity to elucidate etiological and pathogenetic factors influencing the onset and course of psychotic disorders.
- “The European First Episode Schizophrenia Trial (EUFEST)”
I am the statistical advisor of this project. The aim of the European First Episode Schizophrenia Trial (EUFEST) is to compare treatment with amisulpride, quetiapine, olanzapine and ziprasidone to a low dose of haloperidol in an unselected sample of first episode schizophrenia patients with minimal prior exposure to antipsychotics.
- “Optimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE; funded by FP7; 11,800,000 Euro). I am the senior statistical consultant of this project. The main aim of this study is to optimise current treatments in schizophrenia and explore novel therapeutic options for schizophrenia.

October 2010 - April 2011
Visiting scientist, Department of Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia.
The aim of this visit was to collaborate with Prof. Dr. Peter Visscher and Dr. Naomi Wray on a study on the role of Copy Number Variants (CNVs) in mental retardation and schizophrenia. I discovered a novel region which is significantly enriched for large (>1Mb) CNVs in patients with mental retardation and schizophrenia compared to patients with mental retardation only. This work is not yet submitted for publication as the CNVs are currently verified based on PCR analysis but I expect that it will be submitted next month.

January 2007 - October 2007
Postdoc (0.8 fte, fixed term), Department of Biological Psychology, Vrije Universiteit, Amsterdam. This postdoc project was a continuation of the research project which started in September 2006.

October 2006-December 2006
Postdoc (1 fte, fixed term), Department of statistical genetics, Wellcome Trust Center of Human Genetics, Oxford, United Kingdom. In collaboration with Prof. dr. L.R. Cardon and Dr. D.M. Evans, two experts in statistical genetics, I worked on a statistical innovation in Genome Wide Association studies, and developed a method to increase statistical power to detect a functional genetic variant by prediction of unobserved SNPs based on information from the HapMap sample

September 2006-October 2006
Postdoc (0.8 fte, fixed term), Department of Biological Psychology, Vrije Universiteit, Amsterdam.
As part of this position, I collaborated with Prof. dr. M.C. Neale, and studied the psychometric
properties of a questionnaire that is used to assess smoking addiction: the Fagerström test for
nicotine dependence. This collaboration was continued in January, 2007.

September 2001-September 2006
AIO (0.8 fte, fixed term), Department of Biological Psychology, Vrije Universiteit, Amsterdam. The topic of the project was the exploration of genetic and environmental influences on Attention Problems and related childhood behavior problems, such as aggression and anxiety/depression.

GRANTS

2010 Netherlands Brain Foundation: On the role of copy number variants in autism: what about the other allele? PI Dr. J.A.S. Vorstman, 149,500 Euro. I am a co-investigator.
2009 FP7: Optimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE), PI Prof. R.S. Kahn, 11,800,000 Euro. I am the senior statistical advisor.
2008 Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO). Innovational Research Incentives Scheme, VENI. 250,000 Euro.
2006 Rubicon grant from the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO).16,000 Euro

TEACHING AND SUPERVISION

- Promotor of PhD student (expected end date October 2014). Title project "Methodological aspects of genetic association studies"
- Promotor of PhD student (expected end date July 2014). Title project "Longitudinal trajectories of symptom dimensions in adolescents with a family history of schizophrenia or bipolar disorder"
- Promotor of PhD student (expected end date December 2011). Title project "The influence of familial loading on clinical characteristics of patients with schizophrenia and their relatives"
- Initiation and organization of a weekly Statistical Methods workgroup in which I teach a wide variety of statistical methods to master students and PhD students
- Teaching in genetics and methodology (courses "Genes and Behavior", "Genetic Methodology", and the "Mx workshop"

SOFTWARE

- General Statistical software: SPSS, R
- Structural Equation Modeling software: Lisrel, Mplus, LatentGold, Mx
- Software for genetic analyses: Mx, Plink, Merlin, Beagle
- Program Languages: Fortran

 

 

RELATED PROFESSIONAL EXPERIENCE

- Initiator (in collaboration with Professor dr. Burbach) of a new research focus "Systems Neurobiology" which will be financed and implemented by the Division Brain, UMC Utrecht.
- Reviewer for "The Lancet", "Journal of the American Academy of Child and Adolescent Psychiatry", "Neuropsychiatric Genetics", BMC Psychiatry", "Psychiatry Research", "European Journal of Human Genetics", "Comprehensive Psychiatry", PlosOne", "Biological Psychology", and "Psychological Medicine".
-
COLLABORATIONS

- Prof. dr. Peter M. Visscher and Dr. Naomi Wray at the Department of Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia.
Website: http://genepi.qimr.edu.au/staff/?staffusername=peterV
- Prof. dr. Roel Ophoff at the UCLA Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles
- Prof. dr. Dorret Boomsma at the Department of Biological Psychology, Free University, Amsterdam, the Netherlands
- Dr. Denny Borsboom at the Department of Psychological Methods, Faculty of Social and Behavioural Sciences, University of Amsterdam, the Netherlands
http://home.medewerker.uva.nl/d.borsboom/
- Prof. dr. Jeroen Vermunt at the Department of Methodology and Statistics, Tilburg School of Social and Behavioral Sciences, the Netherlands
http://www.tilburguniversity.edu/webwijs/show/?uid=j.k.vermunt
- Prof. dr. Conor V. Dolan at the Department of Biological Psychology, Free University, Amsterdam, the Netherlands

SCIENTIFIC PUBLICATIONS

International (refereed) journals (journal impact factor)

- Derks EM et al. (in revision). The identification of family subtype based on the assessment of subclinical levels of psychosis in relatives.
- Derks EM et al. (in press). Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis. PlosOne.
- Derks EM et al (in press). Segment-wise genome-wide association analysis identifies a candidate region associated with schizophrenia in three independent samples. PlosOne.
- Kirstin Daalman, Kelly M.J. Diederen1, Eske M. Derks1, Remko van Lutterveld1, René S. Kahn1, Iris E.C. Sommer1. Childhood trauma and auditory verbal hallucinations (in press). Psychological Medicine.
- Kirstin Daalman1, Sanne Verkooijen1, Eske M Derks2, André Aleman3, Iris EC Sommer1. (in press). Schizophrenia Research.
- Derks EM, Collin G, van Haren NE, Schnack HG, Hulshoff Pol HE et al. (in press). Schizophr. Res.
- Fleischhacker WW, Derks E, Kahn RS. (in press). Schizophr. Res. 138:39-40
- Maat A., Fett, A, Derks E, GROUP (in press). Social cognition and quality of life in schizophrenia. Psychological Medicine.
- Sommer,I.E., Slotema,C.W., Daskalakis,Z.J., Derks,E.M., Blom,J.D. and van der,G.M. (in press). The Treatment of Hallucinations in Schizophrenia Spectrum Disorders. Schizophrenia Bulletin.
- Stringer,S., Wray,N.R., Kahn,R.S. and Derks,E.M., 2011. Underestimated effect sizes in GWAS: fundamental limitations of single SNP analysis for dichotomous phenotypes. PLoS One. 6, e27964.
- Landolt,K., Rossler,W., Burns,T., jdacic-Gross,V., Galderisi,S., Libiger,J., Naber,D., Derks,E.M., Kahn,R.S. and Fleischhacker,W.W., 2011a. The interrelation of needs and quality of life in first-episode schizophrenia. Eur Arch Psychiatry Clin Neurosci.
- Landolt,K., Rossler,W., Burns,T., jdacic-Gross,V., Galderisi,S., Libiger,J., Naber,D., Derks,E.M., Kahn,R.S. and Fleischhacker,W.W., 2011b. Unmet needs in patients with first-episode schizophrenia: a longitudinal perspective. Psychol Med. 1-13.
- Derks EM, Allardyce J, Boks MP, Vermunt JK, Hijman R, Ophoff RA, Genetic Risk and Outcome in Psychosis (GROUP) (in press). Kraepelin was right: A latent class analysis of symptom dimensions in patients and controls. Schizophrenia Bulletin (7.47)
- Visscher PM, Goddard ME, Derks EM, Wray NR (in press). Evidence based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses. Molecular Psychiatry (15.05)
- Boos HB, Cahn W, van Haren NE, Derks EM, Brouwer RM, Schnack HG, Hulshoff Pol HE, Kahn RS (in press). Focal and global brain measurements in siblings of patients with schizophrenia. Schizophrenia Bulletin (7.47).
- Volavka J, Czobor P, Derks EM, Bitter I, Libiger J, Kahn RS, Fleischhacker WW for the EUFEST Study Group (in press). Efficacy of Antipsychotic Drugs against Hostility in the European First Episode Schizophrenia Trial (EUFEST). Journal of Clinical Psychiatry (5.22).
- Verweij KHW, Derks EM, Hendriks EJE, Kahn RS, Cahn W (in press). A short report on the collection of information through family history interviews. Twin Research and Human Genetics (2.10).
- Derks EM, Fleischhacker WW, Boter H, Peuskens J, Kahn RS for the EUFEST study group (2010). Antipsychotic drug treatment in first-episode psychosis: Should patients be switched to a different antipsychotic drug after two, four, or six weeks of non-response? Journal of Clinical Psychopharmacology, 30(2),176-180 (4.371)
- Gaebel W, Riesbeck M, von Wilmsdorff M, Burns T, Derks EM, Kahn RS, Rossler W, Fleischhacker WW, EUFEST Study Group (in press). Drug attitude as predictor for effectiveness in first-episode schizophrenia: results of an open randomized trial (EUFEST). European Neuropsychopharmacology (3.79).
- Boter H, Derks EM, Fleischhacker WW, Davidson M, Kahn RS (2010). Generalizability of the results of efficacy trials in first-episode schizophrenia: Comparisons between subgroups of participants of the European First Episode Schizophrenia Trial (EUFEST). Journal of Clinical Psychiatry, 71, 58-65. (5.22)
- Lubke GH, Hudziak JJ, Derks EM, van Bijsterveldt CEM, Boomsma DI (2009). Maternal ratings of attention problems and the relation to DSM-IV ADHD: Evidence for the existence of a continuum. Journal of the American Academy of Child and Adolescent Psychiatry, 48, 1085- 93.(4.845)
- Boks MP, Derks EM, Weisenberger DJ, Strengman E, Janson E, Sommer IE, Kahn RS, Ophoff RA (2009). The relationship of DNA methylation with age, gender and genotype in twins and healthy controls. Plos One, e6767.
- Derks EM, Verweij KH, Kahn RS. and Cahn W(2009). The calculation of familial loading in schizophrenia. Schizophrenia Research, 111, 198-199. (4.174)
- Van ’t Ent D., van Beijsterveldt,T.C., Derks EM, Hudziak,J.J., Veltman,D.J., Todd,R.D., Boomsma,D.I. and De Geus,E.J. (2009). Neuroimaging of response interference in twins concordant or discordant for inattention and hyperactivity symptoms. Neuroscience. (3.556)
- Poelen,E.A., Derks EM, Engels,R.C., van Leeuwe,J.F., Scholte,R.H., Willemsen,G. and Boomsma,D.I., 2008. The relative contribution of genes and environment to alcohol use in early adolescents: are similar factors related to initiation of alcohol use and frequency of drinking? Alcohol Clin Exp Res. 32, 975-982. (3.166)
- Derks EM, Hudziak JJ, Dolan CV, Van Beijsterveldt CEM, Verhulst FC, Boomsma DI (2008). Genetic and environmental influences on the relation between Attention Problems and Attention Deficit Hyperactivity disorder. Behavior Genetics, 38, 11-23. (3.289)
- Derks EM, Hudziak JJ , Dolan CV, van Beijsterveldt CEM, Verhulst FC, Boomsma DI (2007). Why More Boys Than Girls With ADHD Receive Treatment: A Study of Dutch Twins. Twin Research and Human Genetics, 10,765-770. (2.097)
- Derks EM, Lehn H, Hudziak, JJ, Heutink P, van Beijsterveldt CEM, Boomsma DI (2007). Attention problems and attention deficit hyperactivity disorder in discordant and concordant MZ twins: Evidence of environmental mediators. Journal of the American Academy of Child and Adolescent Psychiatry,46(1), 83-91 (4.845)
- Derks EM, Dolan CV, Hudziak JJ, Neale MC & Boomsma DI (2007). Assessment and etiology of attention deficit hyperactivity disorder and oppositional defiant disorder in boys and girls. Behavior Genetics, 37, 559-566. (3.289)
- Bartels, M., van Beijsterveldt, C. E. M., Derks, E. M., Stroet, T. M., Polderman, T. J. C., Hudziak, J. J., & Boomsma, D. I. (2007). Young Netherlands Twin Register (Y-NTR): A longitudinal multiple informant study of problem behavior. Twin Research and Human Genetics, 10, 3-11. (2.097)
- Ent DV, Lehn H, Derks EM, Hudziak JJ, Van Strien NM, Veltman DJ, De Geus EJC, Todd RD, & Boomsma DI (2007). A structural MRI study in monozygotic twins concordant or discordant for attention/hyperactivity problems: Evidence for genetic and environmental heterogeneity in the developing brain. Neuroimage, 35, 1004-1020. (5.694)
- Polderman TJC, Derks EM, Hudziak JJ, Verhulst FC, Posthuma D & Boomsma DI (2007). Across the continuum of Attention Skills: A twin study of the SWAN ADHD rating scale. Journal of Child Psychology and Psychiatry, 48, 1080-1087. (4.854)
- Derks EM, Dolan, CV, and Boomsma, DI (2006). A test of the Equal Environment Assumption (EEA) in multivariate twin studies. Twin Research and Human Genetics, 9, 403-411. (2.097)
- Derks EM, Dolan CV, and Boomsma DI (2006). Statistical power to detect genetic and environmental influences in the presence of data missing at random. Twin Research and Human Genetics, 10,159-167. (2.097)
- Derks EM, Hudziak JJ, Van Beijsterveldt CEM, Dolan CV, and Boomsma DI. Genetic analyses of maternal and teacher ratings on Attention Problems in seven-year-old Dutch twins (2006). Behavior Genetics, 36, 833-844. (3.289)
- Derks EM, Hudziak JJ, Dolan CV, Ferdinand RF and Boomsma DI (2006). The relations between DISC-IV DSM diagnoses of ADHD and multi-informant CBCL-AP syndrome scores. Comprehensive Psychiatry, 47, 116-122. (2.054)
- Althoff RR, Copeland WE, Stanger C, Derks EM, Todd RD, Neuman RJ, Boomsma DI, and Hudziak JJ (2006). The Latent Class Structure of ADHD is Stable Across Informants. Twin Research and Human Genetics, 9, 507-522. (2.097)
- Boomsma DI, Rebollo I, Derks EM, Beijsterveldt CEM van, Althoff RR, Rettew DC and Hudziak JJ (2006). Longitudinal Stability of the CBCL-Juvenile Bipolar Disorder Phenotype: A Study in Dutch Twins. Biological Psychiatry, 60, 912- 920. (8.672)
- Hudziak JJ, Althoff RR, Derks EM, Faraone SV and Boomsma DI. Prevalence and genetic architecture of child behavior checklist-juvenile bipolar disorder (2005). Biological Psychiatry, 58, 562-568. (8.672)
- Hudziak JJ, Derks EM, Althoff RR, Rettew DC and Boomsma DI (2005). The genetic and environmental contributions to attention deficit hyperactivity disorder as measured by the Conners' Rating Scales - Revised. American Journal of Psychiatry, 162, 1614-1620. (10.545)
- Hudziak JJ, Derks EM, Althoff RR, Copeland WM and Boomsma DI (2005). The genetic and environmental contributions to oppositional defiant behavior: A multi-informant twin study. Journal of the American Academy of Child and Adolescent Psychiatry, 44, 907-914. (4.845)
- Derks EM, Dolan CV, and Boomsma DI (2004). Effects of censoring on parameter estimates and power in genetic modeling. Twin Research, 7, 659-669. (2.097)
- Derks EM, Hudziak JJ, Van Beijsterveldt CEM, Dolan CV and Boomsma DI (2004). A study of genetic and environmental influences on maternal and paternal CBCL syndrome scores in a large sample of 3-year-old Dutch twins. Behavior Genetics, 34, 571-583. (3.289)
- Hudziak JJ, Beijsterveldt van CEM, Bartels M, Rietveld MJH, Rettew DC, Derks EM and Boomsma DI (2003). Individual differences in aggression: genetic analyses by age, gender, and informant in 3-, 7-, and 10-year-old Dutch twins. Behavior Genetics, 33, 575-589. (3.289)
- Boomsma DI, Vink JM, van Beijsterveldt CEM, Geus EJC, Beem AL, Mulder EJCM, Derks EM, Riese H, Willemsen AHM, Bartels M, van den Berg M, Kupper HM, Polderman JC, Posthuma D, Rietveld MJH, Stubbe JH, Knol LI, Stroet T and van Baal GCM (2002). Netherlands Twin Register: a focus on longitudinal research. Twin Research, 5, 1-6. (2.097)

Selection of conference/Meeting contributions and lectures

- Invited oral presentation: “Segment-wise genome wide association analysis identifies a limited number of replicable candidate regions associated with schizophrenia”. October 6th 2010, World Congress of Psychiatric Genetics, 2010.
- Oral presentation: “Improvement of phenotyping in Genome Wide Association studies on schizophrenia: an application of latent class factor analysis”. November 7th, 2009, World Congress of Psychiatric Genetics, 2009
- Invited lecture: “A Finite Mixture Regression Model for Testing Association at Hidden Loci in Genome-wide Quantitative Trait Association Analysis”. Workshop Genetic Data Analysis, October 2nd , 2007, Amsterdam, the Netherlands.
- Oral presentation: “Monozygotic Twins Discordant for Attention Problems and Attention- Deficit/Hyperactivity Disorder”. Symposium “Attention Problems and ADHD”, April 4th 2006, Vrije Universiteit, Amsterdam, the Netherlands.
- Oral presentation: “Searching for genes related to ADHD: refining the phenotype”. The Dutch Endo-Neuro-Psycho meeting, June 2nd 2005, Doorwerth, the Netherlands.
- Oral presentation: “Genetic analyses of teacher ratings on aggression, attention, and anxiety in 7, 10, and 12-year old children”. The 34th Behavior Genetics Association Annual Meeting, June 28th, 2004, Aix-en-Provence, France.

 


 

Research programmes

Prof. dr. W. van den Brink MD (Addiction: pathogenesis, mechanisms of relapse and treatment effectiveness)

Prof. dr. D.A.J.P. Denys (Deep Brain Stimulation and Obsessive-Compulsive Disorders)

Other research related activities
  • None reported
Current research funding
  • Stichting Volksbond Rotterdam