• Female

Dr. E.M.M. van Leeuwen

Position: Scientific staff member (UD)
Main activities: Patient care, Research
Specialisation: Medical Immunology, Human anti-viral T cell responses, Immunodeficiencies
foto
Focus of research:

T cell responses in human viral infections

Immunodeficiency

AMC themes: Infection & Immunity
Departments: Experimental Immunology
Adrichem ME, Starink MV, van Leeuwen EMM, Kramer C, van Schaik IN, Eftimov F, Drug-induced cutaneous lupus erythematosus after immunoglobulin treatment in chronic inflammatory demyelinating polyneuropathy: a case series. J PERIPHER NERV SYST 2017;-:- [PubMed]
Tuijnenburg P, Cuadrado E, Bosch AM, Kindermann A, Jansen MH, Alders M, van Leeuwen EMM, Kuijpers TW, Humoral Immunodeficiency with Hypotonia, Feeding Difficulties, enteropathy, and Mild eczema Caused by a Classical FOXP3 Mutation. FRONT PEDIATR 2017;5:37 [PubMed]
aan de Kerk DJ. B cells grow up: Studies of B cell activation, proliferation and differentiation in primary antibody deficiencies. S.l.: s.n.; 2016. 183p. ISBN 978-94-6182-706-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kuijpers TW; copromotor(s): van Leeuwen EMM)
Aan de Kerk DJ, Jansen MH, Jolles S, Warnatz K, Seneviratne SL, ten Berge IJM, van Leeuwen EMM, Kuijpers TW, Phenotypic and Functional Comparison of Class Switch Recombination Deficiencies with a Subgroup of Common Variable Immunodeficiencies. J CLIN IMMUNOL 2016;36 (7):656-666 [PubMed]
Cobos Jiménez V, Wit FWNM, Joerink M, Maurer I, Harskamp AM, Schouten J, Prins M, van Leeuwen EMM, Booiman T, Deeks SG, Reiss P, Kootstra NA [Contributors: Reiss P, Wit FWNM, van der Valk M, Schouten J , Kooij KW, van Zoest RA, Elsenga BC, Prins M, Martens M, Moll S, Berkel J, Totté M, Visser GR, Kovalev S, Zaheri S, Hillebregt MMJ, Ruijs YMC, Benschop DP, Reis P, Janssen FR, Heidenrijk M, Zikkenheiner W, Boumans L, Kootstra NA, Harskamp-Holwerda AM, Maurer I, Mangas Ruiz MM, Girigorie AF, Boeser-Nunnink B, Geerlings SE, Godfried MH, Goorhuis A, Hovius JWR, Nellen FJB, van der Meer JTM, van der Poll T, Prins JM, Wiersinga WJ, van Eden J, van Hes AMH, Mutschelknauss M, Nobel HE, Pijnappel FJJ, Westerman AM, de Jong J, Postema PG, Bisschop PHLT, Serlie MJM, Lips P, Dekker E, de Rooij SEJA, Willemsen JMR, Vogt L, Portegies P, Schmand BA, Geurtsen GJ , ter Stege JA, Klein Twennaar M, van Eck-Smit BLF, de Jong M, Richel DJ, Verbraak FD, Demirkaya N , Visser I, Ruhé HG, Nieuwkerk PT, van Steenwijk RP, Dijkers E, Majoie CBLM, Caan MWA, Su T, van Lunsen HW, Nievaard MAF, van den Born BJH, Stroes ESG, Mulder WMC]] , T-Cell Activation Independently Associates With Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment. J INFECT DIS 2016;214 (2):216-225 [PubMed]
de Niet A. New treatment strategies for chronic hepatitis B: Viral, genetic and immunological factors predicting treatment outcome. S.l.: s.n.; 2016. 290p. ISBN 978-94-6259-998-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Beuers UHW, Zaaijer HL; copromotor(s): Reesink HW, van Leeuwen EMM)
de Niet A, Stelma F, Jansen L, Sinnige MJ, Remmerswaal EBM, Takkenberg RB, Kootstra NA, Reesink HW, van Lier RAW, van Leeuwen EMM, Restoration of T cell function in chronic hepatitis B patients upon treatment with interferon based combination therapy. J HEPATOL 2016;64 (3):539-546 [PubMed]
Wieten RW, Goorhuis A, Jonker EFF, de Bree GJ, de Visser AW, van Genderen PJJ, Remmerswaal EBM, ten Berge IJM, Visser LG, Grobusch MP, van Leeuwen EMM, 17D yellow fever vaccine elicits comparable long-term immune responses in healthy individuals and immune-compromised patients. J INFECTION 2016;72 (6):713-722 [PubMed]
Wieten RW, Jonker EFF, van Leeuwen EMM, Remmerswaal EBM, ten Berge IJM, de Visser AW, van Genderen PJJ, Goorhuis A, Visser LG, Grobusch MP, de Bree GJ, A Single 17D Yellow Fever Vaccination Provides Lifelong Immunity; Characterization of Yellow-Fever-Specific Neutralizing Antibody and T-Cell Responses after Vaccination. PLOS ONE 2016;11 (3):e0149871 [PubMed]
de Jong HK, Achouiti A, Koh GCKW, Parry CM, Baker S, Faiz MA, van Dissel JT, Vollaard AM, van Leeuwen EMM, Roelofs JJTH, de Vos AF, Roth J, van der Poll T, Vogl T, Wiersinga WJ, Expression and function of S100A8/A9 (calprotectin) in human typhoid fever and the murine Salmonella model. PLOS NEGLECT TROP D 2015;9 (4):e0003663 [PubMed]
de Pagter APJ, Bredius RGM, Kuijpers TW, Tramper J, van der Burg M, van Montfrans J, Driessen GJ [Contributors: ten Berge JMR, Lambeck AJA, van de Corput CJD, Damoiseaux J, van Deuren M, van de Vosse E, Ellerbroek PM, van Hagen PM, van Leeuwen EMM, van den Berg JM, Rutgers B, Scholvinck L, van Tol MJD, de Vries E, van Well G, de Leeuw K, van der Flier M, Roozendaal C]] , Overview of 15-year severe combined immunodeficiency in the Netherlands: towards newborn blood spot screening. EUR J PEDIATR 2015;174 (9):1183-1188 [PubMed]
Remmerswaal EBM, Klarenbeek PL, Alves NL, Doorenspleet ME, van Schaik BDC, Esveldt REE, Idu MM, van Leeuwen EMM, van der Bom-Baylon N, van Kampen AHC, Koch SD, Pircher H, Bemelman FJ, ten Brinke A, Baas F, ten Berge IJM, van Lier RAW, de Vries N, Clonal evolution of CD8+ T cell responses against latent viruses: relationship among phenotype, localization, and function. J VIROL 2015;89 (1):568-580 [PubMed]
Stelma F, de Niet A, Tempelmans Plat-Sinnige MJ, Jansen L, Takkenberg RB, Reesink HW, Kootstra NA, van Leeuwen EMM, Natural Killer Cell Characteristics in Patients With Chronic Hepatitis B Virus (HBV) Infection Are Associated With HBV Surface Antigen Clearance After Combination Treatment With Pegylated Interferon Alfa-2a and Adefovir. J INFECT DIS 2015;212 (7):1042-1051 [PubMed]
Beurskens CJ, Horn J, de Boer AMT, Schultz MJ, van Leeuwen EM, Vroom MB, Juffermans NP, Cardiac arrest patients have an impaired immune response, which is not influenced by induced hypothermia. CRIT CARE 2014;18 (4):R162 [PubMed]
Havenith SHC, Remmerswaal EBM, Idu MM, van Donselaar-van der Pant KAMI, van der Bom N, Bemelman FJ, van Leeuwen EMM, ten Berge IJM, van Lier RAW, CXCR5+CD4+ follicular helper T cells accumulate in resting human lymph nodes and have superior B cell helper activity. INT IMMUNOL 2014;26 (3):183-192 [PubMed]
Olthof DC, Lammers AJJ, van Leeuwen EMM, Hoekstra JBL, ten Berge IJM, Goslings JC, Antibody response to a T-cell-independent antigen is preserved after splenic artery embolization for trauma. CLIN VACCINE IMMUNOL 2014;21 (11):1500-1504 [PubMed]
Aan de Kerk DJ, Jansen MH, ten Berge IJM, van Leeuwen EMM, Kuijpers TW, Identification of B cell defects using age-defined reference ranges for in vivo and in vitro B cell differentiation. J IMMUNOL 2013;190 (10):5012-5019 [PubMed]
Aan de Kerk DJ, van Leeuwen EMM, Jansen MH, van den Berg JM, Alders M, Vermont CL, van Lier RAW, Pals ST, Kuijpers TW, Aberrant humoral immune reactivity in DOCK8 deficiency with follicular hyperplasia and nodal plasmacytosis. CLIN IMMUNOL 2013;149 (1):25-31 [PubMed]
de Niet A, de Bruijne J, Plat-Sinnige MJT, Takkenberg RB, van Lier RAW, Reesink HW, van Leeuwen EMM, Upregulation of CXCR3 expression on CD8+ T cells due to the pervasive influence of chronic hepatitis B and C virus infection. HUM IMMUNOL 2013;74 (8):899-906 [PubMed]
Drewniak A, Gazendam RP, Tool ATJ, van Houdt M, Jansen MH, van Hamme JL, van Leeuwen EMM, Roos D, Scalais E, de Beaufort C, Janssen H, van den Berg TK, Kuijpers TW, Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency. BLOOD 2013;121 (13):2385-2392 [PubMed]
Kuijpers TW, van Leeuwen EMM, Barendregt BH, Klarenbeek P, Aan de Kerk DJ, Baars PA, Jansen MH, de Vries N, van Lier RAW, van der Burg M, A reversion of an IL2RG mutation in combined immunodeficiency providing competitive advantage to the majority of CD8+ T cells. HAEMATOLOGICA 2013;98 (7):1030-1038 [PubMed]
Martin CE, van Leeuwen EMM, Im SJ, Roopenian DC, Sung YC, Surh CD, IL-7/anti-IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R. BLOOD 2013;121 (22):4484-4492 [PubMed]
Lammers AJJ, de Porto APNA, Bennink RJ, van Leeuwen EMM, Biemond BJ, Goslings JC, van Marle J, ten Berge IJM, Speelman P, Hoekstra JBL, Hyposplenism: Comparison of different methods for determining splenic function. AM J HEMATOL 2012;87 (5):484-489 [PubMed]
Remmerswaal EBM, Havenith SHC, Idu MM, van Leeuwen EMM, van Donselaar KAMI, ten Brinke A, van der Bom-Baylon N, Bemelman FJ, van Lier RAW, ten Berge IJM, Human virus-specific effector-type T cells accumulate in blood but not in lymph nodes. BLOOD 2012;119 (7):1702-1712 [PubMed]
Kuijpers TW, Ijspeert H, van Leeuwen EMM, Jansen MH, Hazenberg MD, Weijer KC, van Lier RAW, van der Burg M, Idiopathic CD4(+) T lymphopenia without autoimmunity or granulomatous disease in the slipstream of RAG mutations. BLOOD 2011;117 (22):5892-5896 [PubMed]
Létourneau S, van Leeuwen EMM, Krieg C, Martin C, Pantaleo G, Sprent J, Surh CD, Boyman O, IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25. P NATL ACAD SCI USA 2010;107 (5):2171-2176 [PubMed]
van Leeuwen EMM, Sprent J, Surh CD, Generation and maintenance of memory CD4(+) T Cells. CURR OPIN IMMUNOL 2009;21 (2):167-172 [PubMed]
Alves NL, van Leeuwen EMM, Derks IAM, van Lier RAW, Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling. J IMMUNOL 2008;180 (8):5201-5210 [PubMed]
van de Berg PJ, van Leeuwen EM, ten Berge IJ, van Lier R, Cytotoxic human CD4(+) T cells. CURR OPIN IMMUNOL 2008;20 (3):339-343 [PubMed]
Alves NL, van Leeuwen EMM, Remmerswaal EBM, Vrisekoop N, Tesselaar K, Roosnek E, ten Berge IJM, van Lier RAW, A new subset of human naive CD8+ T cells defined by low expression of IL-7R alpha. J IMMUNOL 2007;179 (1):221-228 [PubMed]
de Bree GJ, van Leeuwen EMM, ten Berge RJM, Immunologische afweer tegen virale infecties: virusspecifieke T-cellen in beeld. NED TIJDSCHR GENEESKD 2007;151 (44):2440-2444 [PubMed]
van Leeuwen EMM, ten Berge IJM, van Lier RAW, Induction and maintenance of CD8+ T cells specific for persistent viruses. ADV EXP MED BIOL 2007;590:121-137 [PubMed]
van Leeuwen EMM, van Lier RAW, ten Berge IJA, Response to comment on "differential usage of cellular niches by cytomegalovirus versus EBV and influenza virus-specific CDB+ T cells". J IMMUNOL 2007;178 (5):2612
van Leeuwen EMM, de Bree GJ, ten Berge IJM, van Lier RAW, Human virus-specific CD8+ T cells: diversity specialists. IMMUNOL REV 2006;211:225-235 [PubMed]
van Leeuwen EMM, Koning JJ, Remmerswaal EBM, van Baarle D, van Lier RAW, ten Berge IJM, Differential usage of cellular niches by cytomegalovirus versus EBV- and influenza virus-specific CD8+ T cells. J IMMUNOL 2006;177 (8):4998-5005 [PubMed]
van Leeuwen EMM, Remmerswaal EBM, Heemskerk MHM, ten Berge IJM, van Lier RAW, Strong selection of virus-specific cytotoxic CD4+ T-cell clones during primary human cytomegalovirus infection. BLOOD 2006;108 (9):3121-3127 [PubMed]
de Bree GJ, Heidema J, van Leeuwen EMM, van Bleek GM, Jonkers RE, Jansen HM, van Lier RAW, Out TA, Respiratory syncytial virus-specific CD8+ memory T cell responses in elderly persons. J INFECT DIS 2005;191 (10):1710-1718 [PubMed]
de Bree GJ, van Leeuwen EMM, Out TA, Jansen HM, Jonkers RE, van Lier RAW, Selective accumulation of differentiated CD8+ T cells specific for respiratory viruses in the human lung. J EXP MED 2005;202 (10):1433-1442 [PubMed]
Rowshani AT, Bemelman FJ, van Leeuwen EMM, van Lier RAW, ten Berge IJM, Clinical and immunologic aspects of cytomegalovirus infection in solid organ transplant recipients. TRANSPLANTATION 2005;79 (4):381-386 [PubMed]
van Leeuwen EMM. Induction and maintenance of human virus-specific T cells. S.l.: s.n.; 2005. 180p. ISBN 90-9020200-5 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): ten Berge RJM, van Lier RAW; copromotor(s): )
van Leeuwen EMM, de Bree GJ, Remmerswaal EBM, Yong SL, Tesselaar K, ten Berge IJM, van Lier RAW, IL-7 receptor alpha chain expression distinguishes functional subsets of virus-specific human CD8+ T cells. BLOOD 2005;106 (6):2091-2098 [PubMed]
van Leeuwen EMM, van Buul JD, Remmerswaal EBM, Hordijk PL, ten Berge IJM, van Lier RAW, Functional re-expression of CCR7 on CMV-specific CD8+ T cells upon antigenic stimulation. INT IMMUNOL 2005;17 (6):713-719 [PubMed]
Gamadia LE, van Leeuwen EMM, Remmerswaal EBM, Yong SL, Surachno S, Wertheim-van Dillen PME, ten Berge IJM, van Lier RAW, The size and phenotype of virus-specific T cell populations is determined by repetitive antigenic stimulation and environmental cytokines. J IMMUNOL 2004;172 (10):6107-6114 [PubMed]
Nikolaeva N, Uss E, van Leeuwen EMM, van Lier RAW, ten Berge IJM, Differentiation of human alloreactive CD4+ and CD8+ T cells in vitro. TRANSPLANTATION 2004;78 (6):815-824 [PubMed]
van Leeuwen EMM, Remmerswaal EBM, Vossen MTM, Rowshani AT, Wertheim-van Dillen PME, van Lier RAW, ten Berge IJM, Emergence of a CD4+CD28- granzyme B+, cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infection. J IMMUNOL 2004;173 (3):1834-1841 [PubMed]
van Leeuwen EM, Gamadia LE, Baars PA, Remmerswaal EB, ten Berge IJ, van Lier RA, Proliferation requirements of cytomegalovirus-specific, effector-type human CD8+ T cells. J IMMUNOL 2002;169 (10):5838-5843 [PubMed]
de Haas CJ, van Leeuwen EM, van Bommel T, Verhoef J, van Kessel KP, van Strijp JA, Serum amyloid P component bound to gram-negative bacteria prevents lipopolysaccharide-mediated classical pathway complement activation. INFECT IMMUN 2000;68 (4):1753-1759 [PubMed]
Key publications

Aan de Kerk DJ, Jansen MH, ten Berge IJM, van Leeuwen EMM, Kuijpers TW, Identification of B cell defects using age-defined reference ranges for in vivo and in vitro B cell differentiation. J IMMUNOL 2013;190 (10):5012-5019 [PubMed]
de Niet A, de Bruijne J, Plat-Sinnige MJT, Takkenberg RB, van Lier RAW, Reesink HW, van Leeuwen EMM, Upregulation of CXCR3 expression on CD8+ T cells due to the pervasive influence of chronic hepatitis B and C virus infection. HUM IMMUNOL 2013;74 (8):899-906 [PubMed]
Létourneau S, van Leeuwen EMM, Krieg C, Martin C, Pantaleo G, Sprent J, Surh CD, Boyman O, IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25. P NATL ACAD SCI USA 2010;107 (5):2171-2176 [PubMed]
van Leeuwen EMM, Sprent J, Surh CD, Generation and maintenance of memory CD4(+) T Cells. CURR OPIN IMMUNOL 2009;21 (2):167-172 [PubMed]
Kuijpers TW, van Leeuwen EMM, Barendregt BH, Klarenbeek P, Aan de Kerk DJ, Baars PA, Jansen MH, de Vries N, van Lier RAW, van der Burg M, A reversion of an IL2RG mutation in combined immunodeficiency providing competitive advantage to the majority of CD8+ T cells. HAEMATOLOGICA 2013;98 (7):1030-1038 [PubMed]


All Publications

Research programmes

Prof. dr. T.B.H. Geijtenbeek (Dendritic cells in infection and immunity)

Other research related activities
  • None reported
Current research funding
  • None reported