• Male

Dr. R.L. Hamers

Position: Postdoc
Main activities: Patient care, Research
Specialisation: internal medicine and infectious diseases
foto
Focus of research:

HIV treatment in resource-limited settings, in particular antiretroviral drug resistance and chronic immune dysregulation

AMC themes: Infection & Immunity, Public Health & Epidemiology
Departments: Global Health, Internal Medicine: Infectious diseases
Bijker R, Jiamsakul A, Kityo C, Kiertiburanakul S, Siwale M, Phanuphak P, Akanmu S, Chaiwarith R, Wit FW, Sim BL, Boender TS, Ditangco R, Rinke de Wit TF, Sohn AH, Hamers RL, Adherence to antiretroviral therapy for HIV in sub-Saharan Africa and Asia: a comparative analysis of two regional cohorts. J INT AIDS SOC 2017;20 (1):1-10 [PubMed]
Gregson J, Kaleebu P, Marconi VC, van Vuuren C, Ndembi N, Hamers RL, Kanki P, Hoffmann CJ, Lockman S, Pillay D, de Oliveira T, Clumeck N, Hunt G, Kerschberger B, Shafer RW, Yang C, Raizes E, Kantor R, Gupta RK, Occult HIV-1 drug resistance to thymidine analogues following failure of first-line tenofovir combined with a cytosine analogue and nevirapine or efavirenz in sub Saharan Africa: a retrospective multi-centre cohort study. LANCET INFECT DIS 2017;17 (3):296-304 [PubMed]
Inzaule SC, Hamers RL, Calis J , Boerma R, Sigaloff K, Zeh C, Mugyenyi P, Akanmu S, Rinke de Wit TF, When prevention of mother-to-child HIV transmission fails: preventing pretreatment drug resistance in African children. AIDS 2017;ahead of print [PubMed]
Inzaule SC, Hamers RL, Kityo C, Rinke de Wit TF, Roura M, Long-Term Antiretroviral Treatment Adherence in HIV-Infected Adolescents and Adults in Uganda: A Qualitative Study (vol 11, e0167492, 2016). PLOS ONE 2017;12 (2):e0172077 [PubMed]
Inzaule SC, Hamers RL, Mukui I, Were K, Owiti P, Kwaro D, Rinke de Wit TF, Zeh C, Emergence of untreatable, multidrug-resistant HIV-1 in patients failing second-line therapy in Kenya. AIDS 2017;31 (10):1495-1498 [PubMed]
Inzaule SC, Hamers RL, Paredes R, Yang C, Schuurman R, Rinke de Wit TF, The evolving landscape of HIV drug resistance diagnostics for expanding testing in resource-limited settings. AIDS REV 2017;ahead of print [PubMed]
Paredes R, Tzou PL, van Zyl G, Barrow G, Camacho R, Carmona S, Grant PM, Gupta RK, Hamers RL, Harrigan PR, Jordan MR, Kantor R, Katzenstein DA, Kuritzkes DR, Maldarelli F, Otelea D, Wallis CL, Schapiro JM, Shafer RW, Collaborative update of a rule-based expert system for HIV-1 genotypic resistance test interpretation. PLOS ONE 2017;12 (7):e0181357 [PubMed]
Rhee SY, Varghese V, Holmes SP, van Zyl GU, Steegen K, Boyd MA, Cooper DA, Nsanzimana S, Saravanan S, Charpentier C, de Oliveira T, Etiebet MAA, Garcia F, Goedhals D, Gomes P, Günthard HF, Hamers RL, Hoffmann CJ, Hunt G, Jiamsakul A, Kaleebu P, Kanki P, Kantor R, Kerschberger B, Marconi VC, D'amour Ndahimana J, Ndembi N, Ngo-Giang-Huong N, Rokx C, Santoro MM, Schapiro JM, Schmidt D, Seu L, Sigaloff KCE, Sirivichayakul S, Skhosana L, Sunpath H, Tang M, Yang C, Carmona S, Gupta RK, Shafer RW, Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration. EBIOMEDICINE 2017;18:225-235 [PubMed]
Boender TS, Hamers RL, Ondoa P, Wellington M, Chimbetete C, Siwale M, Labib Maksimos EEF, Balinda SN, Kityo CM, Adeyemo TA, Akanmu AS, Mandaliya K, Botes ME, Stevens W, Rinke de Wit TF, Sigaloff KCE, Protease Inhibitor Resistance in the First 3 Years of Second-Line Antiretroviral Therapy for HIV-1 in Sub-Saharan Africa. J INFECT DIS 2016;214 (6):873-883 [PubMed]
Boender TS, Kityo CM, Boerma RS, Hamers RL, Ondoa P, Wellington M, Siwale M, Nankya I, Kaudha E, Akanmu AS, Botes ME, Steegen K, Calis JCJ, Rinke de Wit TF, Sigaloff KCE, Accumulation of HIV-1 drug resistance after continued virological failure on first-line ART in adults and children in sub-Saharan Africa. J ANTIMICROB CHEMOTH 2016;71 (10):2918-2927 [PubMed]
Gregson J, Tang M, Ndembi N, Hamers RL, Rhee SY, Marconi VC, Diero L, Brooks K, Theys K, de Wit TFR, Arruda M, Garcia F, Monge S, Gunthard HF, Hoffmann CJ, Kanki PJ, Kumarasamy N, Kerschberger B, Mor O, Charpentier C, Todesco E, Rokx C, Gras L, Halvas EK, Sunpath H, Di Carlo D, Antinori A, Andreoni M, Latini A, Mussini C, Aghokeng A, Sonnerborg A, Neogi U, Fessel WJ, Agolory S, Yang C, Blanco JL, Juma JM, Smit E, Schmidt D, Watera C, Asio J, Kirungi W, Tostevin A, El-Hay T, Clumeck N, Goedhals D, van Vuuren C, Bester PA, Sabin C, Mukui I, Santoro MM, Perno CF, Hunt G, Morris L, Camacho R, de Oliveira T, Pillay D, Schulter E, Murakami-Ogasawara A, Reyes-Teran G, Romero K, Avila-Rios S, Sirivichayakul S, Ruxrungtham K, Mekprasan S, Dunn D, Kaleebu P, Raizes E, Kantor R, Shafer RW, Gupta RK, Global epidemiology of drug resistance after failure of WHO recommended first-line regimens for adult HIV-1 infection: a multicentre retrospective cohort study. LANCET INFECT DIS 2016;16 (5):565-575
Hamers RL, Enhancement of clinical decision making in HIV care in Africa. LANCET HIV 2016;3 (2):e59-e60 [PubMed]
Hamers RL, Paredes R, Next-generation sequencing and HIV drug resistance surveillance. LANCET HIV 2016;3 (12):E553-E554 [PubMed]
Hamers RL, van Gool T, Goorhuis A, Benznidazole for Chronic Chagas' Cardiomyopathy. NEW ENGL J MED 2016;374 (2):188 [PubMed]
Inzaule SC, Hamers RL, Kityo C, Rinke de Wit TF, Roura M, Long-Term Antiretroviral Treatment Adherence in HIV-Infected Adolescents and Adults in Uganda: A Qualitative Study. PLOS ONE 2016;11 (11):e0167492 [PubMed]
Inzaule SC, Hamers RL, Zeh CE, Rinke de Wit TF, Stringent HIV Viral Load Threshold for Virological Failure Using Dried Blood Spots: Is the Perfect the Enemy of the Good?. JAIDS-J ACQ IMM DEF 2016;71 (1):e30-e33 [PubMed]
Inzaule SC, Ondoa P, Peter T, Mugyenyi PN, Stevens WS, Rinke de Wit TF, Hamers RL, Affordable HIV drug-resistance testing for monitoring of antiretroviral therapy in sub-Saharan Africa. LANCET INFECT DIS 2016;16 (11):e267-e275 [PubMed]
Inzaule SC, Weidle PJ, Yang C, Ndiege K, Hamers RL, Rinke de Wit TF, Thomas T, Zeh C, Prevalence and dynamics of the K65R drug resistance mutation in HIV-1-infected infants exposed to maternal therapy with lamivudine, zidovudine and either nevirapine or nelfinavir in breast milk. J ANTIMICROB CHEMOTH 2016;71 (6):1619-1626 [PubMed]
Revell AD, Wang D, Wood R, Morrow C, Tempelman H, Hamers RL, Reiss P, van Sighem AI, Nelson M, Montaner JSG, Lane HC, Larder BA [Contributors: Reiss P, van Sighem A, Montaner J, Harrigan R, de Wit TR, Hamers R, Sigaloff K, Agan B, Marconi V, Wegner S, Sugiura W, Zazzi M, Kaiser R, Schuelter E, Streinu-Cercel A, Alvarez-Uria G, Gatell J, Lazzari E, Gazzard B, Nelson M, Pozniak A, Mandalia S, Webster D, Smith C, Ruiz L, Clotet B, Staszewski S, Torti C, Lane C, Metcalf J, Perez-Elias MJ, Vella S, Dettorre G, Carr A, Norris R, Hesse K, Vlahakis E, Tempelman H, Barth R, Morrow C, Wood R, Hoffmann C, Ene L, Dragovic G, Diaz R, Sucupira C, Sued O, Cesar C, Madero JS, Emery S, Cooper D, Baxter J, Monno L, Clotet B, Picchio G, Debethune MP, Khabo P, Ledwaba L]] , An update to the HIV-TRePS system: the development and evaluation of new global and local computational models to predict HIV treatment outcomes, with or without a genotype. J ANTIMICROB CHEMOTH 2016;71 (10):2928-2937 [PubMed]
Revell A, Khabo P, Ledwaba L, Emery S, Wang D, Wood R, Morrow C, Tempelman H, Hamers RL, Reiss P, van Sighem A, Pozniak A, Montaner J, Lane HC, Larder B, Computational models as predictors of HIV treatment outcomes for the Phidisa cohort in South Africa. S AFR J HIV MED 2016;17 (1):450
Boender TS, Hoenderboom BM, Sigaloff KCE, Hamers RL, Wellington M, Shamu T, Siwale M, Labib Maksimos EEF, Nankya I, Kityo CM, Adeyemo TA, Akanmu AS, Mandaliya K, Botes ME, Ondoa P, Rinke de Wit TF, Pretreatment HIV drug resistance increases regimen switches in sub-Saharan Africa. CLIN INFECT DIS 2015;61 (11):1749-1758 [PubMed]
Rhee SY, Blanco JL, Jordan MR, Taylor J, Lemey P, Varghese V, Hamers RL, Bertagnolio S, Rinke de Wit TF, Aghokeng AF, Albert J, Avi R, Avila-Rios S, Bessong PO, Brooks JI, Boucher CAB, Brumme ZL, Busch MP, Bussmann H, Chaix ML, Chin BS, D'Aquin TT, de Gascun CF, Derache A, Descamps D, Deshpande AK, Djoko CF, Eshleman SH, Fleury H, Frange P, Fujisaki S, Harrigan PR, Hattori J, Holguin A, Hunt GM, Ichimura H, Kaleebu P, Katzenstein D, Kiertiburanakul S, Kim JH, Kim SS, Li Y, Lutsar I, Morris L, Ndembi N, Ng KP, Paranjape RS, Peeters M, Poljak M, Price MA, Ragonnet-Cronin ML, Reyes-Terán G, Rolland M, Sirivichayakul S, Smith DM, Soares MA, Soriano VV, Ssemwanga D, Stanojevic M, Stefani MA, Sugiura W, Sungkanuparph S, Tanuri A, tee KK, Truong HHM, van de Vijver DAMC, Vidal N, Yang C, Yang R, Yebra G, Ioannidis JPA, Vandamme AM, Shafer RW, Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis. PLOS MED 2015;12 (4):e1001810 [PubMed]
Rhee SY, Jordan MR, Raizes E, Chua A, Parkin N, Kantor R, van Zyl GU, Mukui I, Hosseinipour MC, Frenkel LM, Ndembi N, Hamers RL, Rinke de Wit TF, Wallis CL, Gupta RK, Fokam J, Zeh C, Schapiro JM, Carmona S, Katzenstein D, Tang M, Aghokeng AF, de Oliveira T, Wensing AMJ, Gallant JE, Wainberg MA, Richman DD, Fitzgibbon JE, Schito M, Bertagnolio S, Yang C, Shafer RW, HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing. PLOS ONE 2015;10 (12):e0145772 [PubMed]
Bezemer D, Faria NR, Hassan A, Hamers RL, Mutua G, Anzala O, Mandaliya K, Cane P, Berkley JA, Rinke de Wit TF, Wallis C, Graham SM, Price MA, Coutinho RA, Sanders EJ, HIV Type 1 transmission networks among men having sex with men and heterosexuals in Kenya. AIDS RES HUM RETROV 2014;30 (2):118-126 [PubMed]
Nichols BE, Sigaloff KCE, Kityo C, Hamers RL, Baltussen R, Bertagnolio S, Jordan MR, Hallett TB, Boucher CAB, de Wit TFR, van de Vijver DAMC, Increasing the use of second-line therapy is a cost-effective approach to prevent the spread of drug-resistant HIV: a mathematical modelling study. J INT AIDS SOC 2014;17 (1):19164 [PubMed]
Nichols BE, Sigaloff KCE, Kityo C, Mandaliya K, Hamers RL, Bertagnolio S, Jordan MR, Boucher CAB, Rinke de Wit TF, van de Vijver DAMC, Averted HIV infections due to expanded antiretroviral treatment eligibility offsets risk of transmitted drug resistance: a modeling study. AIDS 2014;28 (1):73-83 [PubMed]
Revell AD, Wang D, Wood R, Morrow C, Tempelman H, Hamers R, Alvarez-Uria G, Streinu-Cercel A, Ene L, Wensing A, Reiss P, van Sighem AI, Nelson M, Emery S, Montaner JSG, Lane HC, Larder BA [Contributors: Reiss P, van Sighem A, Montaner J, Harrigan R, Rinke de Wit T, Hamers R, Sigaloff K, Agan B, Marconi V, Wegner S, Sugiura W, Zazzi M, Streinu-Cercel A, Alvarez-Uria G, Gatell J, Lazzari E, Gazzard B, Nelson M, Pozniak A, Mandalia S, Ruiz L, Clotet B, Staszewski S, Torti C, Lane C, Metcalf J, Perez-Elias MJ, Carr A, Norris R, Hesse K, Vlahakis E, Tempelman H, Barth R, Morrow C, Wood R, Ene L, Dragovic G, Emery S, Cooper D, Baxter J, Monno L, Clotet B, Picchio G, Debethune MP]] , An update to the HIV-TRePS system: the development of new computational models that do not require a genotype to predict HIV treatment outcomes. J ANTIMICROB CHEMOTH 2014;69 (4):1104-1110 [PubMed]
de Luca A, Hamers RL, Schapiro JM, Antiretroviral treatment sequencing strategies to overcome HIV type 1 drug resistance in adolescents and adults in low-middle-income countries. J INFECT DIS 2013;207 (Suppl. 2):S63-S69 [PubMed]
Hamers RL. Drug-resistant HIV-1 in sub-Saharan Africa. Clinical and public health studies. s.l: s.n.; 2013. 365p. ISBN 9789461693297 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Rinke de Wit TF, Mugyenyi P; copromotor(s): van Vugt M, Schuurman R)
Hamers RL, Kityo C, Sigaloff KCE, Rinke de Wit TF, Pretreatment HIV-1 drug resistance in Africa. LANCET INFECT DIS 2013;13 (6):476 [PubMed]
Hamers RL, Sigaloff KCE, Kityo C, Mugyenyi P, de Wit TFR, Emerging HIV-1 drug resistance after roll-out of antiretroviral therapy in sub-Saharan Africa. CURR OPIN HIV AIDS 2013;8 (1):19-26 [PubMed]
Hamers RL, Sigaloff KCE, Kityo C, Mugyenyi P, Rinke de Wit TF, HIV-1 drug resistance in antiretroviral-naive patients in sub-Saharan Africa. LANCET INFECT DIS 2013;13 (3):196-197 [PubMed]
Hamers RL, Zaaijer HL, Wallis CL, Siwale M, Ive P, Botes ME, Sigaloff KCE, Hoepelman AIM, Stevens WS, Rinke de Wit TF, HIV-HBV coinfection in Southern Africa and the effect of lamivudine- versus tenofovir-containing cART on HBV outcomes. JAIDS-J ACQ IMM DEF 2013;64 (2):174-182 [PubMed]
Revell AD, Wang D, Wood R, Morrow C, Tempelman H, Hamers RL, Alvarez-Uria G, Streinu-Cercel A, Ene L, Wensing AMJ, DeWolf F, Nelson M, Montaner JS, Lane HC, Larder BA, Computational models can predict response to HIV therapy without a genotype and may reduce treatment failure in different resource-limited settings. J ANTIMICROB CHEMOTH 2013;68 (6):1406-1414 [PubMed]
Sigaloff KCE, Kayiwa J, Musiime V, Calis JCJ, Kaudha E, Mukuye A, Matama C, Nankya I, Nakatudde L, Dekker JT, Hamers RL, Mugyenyi P, Rinke de Wit TF, Kityo C, Short communication: high rates of thymidine analogue mutations and dual-class resistance among HIV-infected Ugandan children failing first-line antiretroviral therapy. AIDS RES HUM RETROV 2013;29 (6):925-930 [PubMed]
Tang MW, Rhee SY, Bertagnolio S, Ford N, Holmes S, Sigaloff KC, Hamers RL, Rinke de Wit TF, Fleury HJ, Kanki PJ, Ruxrungtham K, Hawkins CA, Wallis CL, Stevens W, van Zyl GU, Manosuthi W, Hosseinipour MC, Ngo-Giang-Huong N, Belec L, Peeters M, Aghokeng A, Bunupuradah T, Burda S, Cane P, Cappelli G, Charpentier C, Dagnra AY, Deshpande AK, El-Katib Z, Eshleman SH, Fokam J, Gody JC, Katzenstein D, Koyalta DD, Kumwenda JJ, Lallemant M, Lynen L, Marconi VC, Margot NA, Moussa S, Ndung'u T, Nyambi PN, Orrell C, Schapiro JM, Schuurman R, Sirivichayakul S, Smith D, Zolfo M, Jordan MR, Shafer RW, Nucleoside reverse transcriptase inhibitor resistance mutations associated with first-line stavudine-containing antiretroviral therapy: programmatic implications for countries phasing out stavudine. J INFECT DIS 2013;207 (Suppl. 2):S70-S77 [PubMed]
Boender TS, Sigaloff KCE, Kayiwa J, Musiime V, Calis JCJ, Hamers RL, Nakatudde LK, Khauda E, Mukuye A, Ditai J, Geelen SP, Mugyenyi P, Rinke de Wit TF, Kityo C, Barriers to Initiation of Pediatric HIV Treatment in Uganda: A Mixed-Method Study. AIDS RES TREAT 2012;2012:817506 [PubMed]
Gupta RK, Jordan MR, Sultan BJ, Hill A, Davis DHJ, Gregson J, Sawyer AW, Hamers RL, Ndembi N, Pillay D, Bertagnolio S, Global trends in antiretroviral resistance in treatment-naive individuals with HIV after rollout of antiretroviral treatment in resource-limited settings: a global collaborative study and meta-regression analysis. LANCET 2012;380 (9849):1250-1258 [PubMed]
Hamers RL, Kityo C, Lange JMA, de Wit TFR, Mugyenyi P, Global threat from drug resistant HIV in sub-Saharan Africa. BMJ-BRIT MED J 2012;344:e4159 [PubMed]
Hamers RL, Oyomopito R, Kityo C, Phanuphak P, Siwale M, Sungkanuparph S, Conradie F, Kumarasamy N, Botes ME, Sirisanthana T, Abdallah S, Li PCK, Ngorima N, Kantipong P, Osibogun A, Lee CKC, Stevens WS, Kamarulzaman A, Derdelinckx I, Chen YMA, Schuurman R, van Vugt M, Rinke de Wit TF [Contributors: Njovu C, Labib M, Menke J, Botes ME, Conradie F, Sanne I, Wallis CL, Stevens WS, Hardman M, Ngorima N, Wellington M, Luthy R, Mandaliya K, Abdallah S, Jao I, Dolan M, Kityo C, Namayanja G, Nakatudde L, Kiconco M, Abwola M, Mugyenyi P, Kaleebu P, Osibogun A, Akanmu S, Wensing AM, Derdelinckx I, Schuurman R, Hamers RL, Sigaloff K, Straatsma E, van Vugt M, Rinke de Wit TF, Li PCK, Lee MP, Wong KH, Kumarasamy N, Saghayam S, Pujari S, Joshi K, Merati TP, Yuliana F, Lee CKC, Low LL, Kamarulzaman A, Ong LY, Mustafa M, Nordin N, Ditangco R, Bantique RO, Chen YMA, Wong WW, Yang YW, Phanuphak P, Sirivichayakul S, Sungkanuparph S, Piyavong B, Sirisanthana T, Praparattanapan J, Kantipong P, Kambua P, Choi JY, Han SH, Ratanasuwan W, Sriondee R, Kantor R, Sohn AH, Messerschmidt L, Singtoroj T, Cooper DA, Law MG, Jiamsakul A, Zhou J]] , Cohort Profile: The PharmAccess African (PASER-M) and the TREAT Asia (TASER-M) Monitoring Studies to Evaluate Resistance-HIV drug resistance in sub-Saharan Africa and the Asia-Pacific. INT J EPIDEMIOL 2012;41 (1):43-54 [PubMed]
Hamers RL, Sawyer AW, Tuohy M, Stevens WS, Rinke de Wit TF, Hill AM, Cost-effectiveness of laboratory monitoring for management of HIV treatment in sub-Saharan Africa: a model-based analysis. AIDS 2012;26 (13):1663-1672 [PubMed]
Hamers RL, Schuurman R, Sigaloff KCE, Wallis CL, Kityo C, Siwale M, Mandaliya K, Ive P, Botes ME, Wellington M, Osibogun A, Wit FW, van Vugt M, Stevens WS, de Wit TFR, Effect of pretreatment HIV-1 drug resistance on immunological, virological, and drug-resistance outcomes of first-line antiretroviral treatment in sub-Saharan Africa: a multicentre cohort study. LANCET INFECT DIS 2012;12 (4):307-317 [PubMed]
Hamers RL, Sigaloff KCE, Wensing AM, Wallis CL, Kityo C, Siwale M, Mandaliya K, Ive P, Botes ME, Wellington M, Osibogun A, Stevens WS, Rinke de Wit TF, Schuurman R [Contributors: Siwale M, Njovu C, Labib M, Menke J, Botes ME, Conradie F, Ive P, Sanne I, Wallis CL, Letsoalo E, Stevens WS, Hardman M, Wellington M, Luthy R, Mandaliya K, Abdallah S, Jao I, Dolan M, Kityo C, Namayanja G, Nakatudde L, Nankya I, Kiconco M, Abwola M, Mugyenyi P, Osibogun A, Akanmu S, Schuurman R, Wensing AM, Hamers RL, Sigaloff KCE, Straatsma E, Wit FW, Dekker J, van Vugt M, Lange JM, Rinke de Wit TF]] , Patterns of HIV-1 Drug Resistance After First-Line Antiretroviral Therapy (ART) Failure in 6 Sub-Saharan African Countries: Implications for Second-Line ART Strategies. CLIN INFECT DIS 2012;54 (11):1660-1669 [PubMed]
Hamers RL, Straatsma E, Kityo C, Wallis CL, Stevens WS, Sigaloff KCE, Siwale M, Conradie F, Botes ME, Mandaliya K, Wellington M, Osibogun A, van Vugt M, Rinke de Wit TF, Building Capacity for the Assessment of HIV Drug Resistance: Experiences From the PharmAccess African Studies to Evaluate Resistance Network. CLIN INFECT DIS 2012;54 (4):S261-S265 [PubMed]
Sigaloff KCE, Hamers RL, Menke J, Labib M, Siwale M, Ive P, Botes ME, Kityo C, Mandaliya K, Wellington M, Osibogun A, Geskus RB, Stevens WS, van Vugt M, Rinke de Wit TF, Early Warning Indicators for Population-Based Monitoring of HIV Drug Resistance in 6 African Countries. CLIN INFECT DIS 2012;54 (4):S294-S299 [PubMed]
Sigaloff KCE, Hamers RL, Wallis CL, Kityo C, Siwale M, Ive P, Botes ME, Mandaliya K, Wellington M, Osibogun A, Stevens WS, van Vugt M, Rinke de Wit TF, Second-Line Antiretroviral Treatment Successfully Resuppresses Drug-Resistant HIV-1 After First-Line Failure: Prospective Cohort in Sub-Saharan Africa. J INFECT DIS 2012;205 (11):1739-1744 [PubMed]
Sigaloff KCE, Mandaliya K, Hamers RL, Otieno F, Jao IM, Lyagoba F, Magambo B, Kapaata A, Ndembi N, Rinke de Wit TF, Short Communication High Prevalence of Transmitted Antiretroviral Drug Resistance Among Newly HIV Type 1 Diagnosed Adults in Mombasa, Kenya. AIDS RES HUM RETROV 2012;28 (9):833-837 [PubMed]
Hamers RL, Wallis CL, Kityo C, Siwale M, Mandaliya K, Conradie F, Botes ME, Wellington M, Osibogun A, Sigaloff KCE, Nankya I, Schuurman R, Wit FW, Stevens WS, van Vugt M, de Wit TFR [Contributors: Mandaliya K, Abdallah S, Jao I, Dolan M, Schuurman R, Wensing AM, Hamers RL, Sigaloff KCE, Straatsma E, Wit FW, van Vugt M, Lange JM, Rinke de Wit TF, Osibogun A, Akanmu S, Botes ME, Conradie F, Ive P, Sanne I, Wallis CL, Letsoalo E, Stevens WS, Hardman M, Kityo C, Namayanja G, Nakatudde L, Nankya I, Kiconco M, Abwola M, Mugyenyi P, Ndembi N, Lyagoba F, Kaleebu P, Siwale M, Njovu C, Labib M, Menke J, Wellington M, Luthy R]] , HIV-1 drug resistance in antiretroviral-naive individuals in sub-Saharan Africa after rollout of antiretroviral therapy: a multicentre observational study. LANCET INFECT DIS 2011;11 (10):750-759 [PubMed]
Hamers RL, Wensing AMJ, Back NKT, Arcilla MS, Frissen JPH, Multi-nucleoside reverse transcriptase inhibitor resistant HIV type-1 in a patient from Sierra Leone failing stavudine, lamivudine and nevirapine. ANTIVIR THER 2011;16 (1):115-118 [PubMed]
Ndembi N, Hamers RL, Sigaloff KCE, Lyagoba F, Magambo B, Nanteza B, Watera C, Kaleebu P, Rinke de Wit TF, Transmitted antiretroviral drug resistance among newly HIV-1 diagnosed young individuals in Kampala. AIDS 2011;25 (7):905-910 [PubMed]
Sigaloff KCE, Hamers RL, Wallis CL, Kityo C, Siwale M, Ive P, Botes ME, Mandaliya K, Wellington M, Osibogun A, Stevens WS, van Vugt M, Rinke de Wit TF, Unnecessary Antiretroviral Treatment Switches and Accumulation of HIV Resistance Mutations; Two Arguments for Viral Load Monitoring in Africa. JAIDS-J ACQ IMM DEF 2011;58 (1):23-31 [PubMed]
Welzen MEB, van den Berk GEL, Hamers RL, Burger DM, Interaction between antiretroviral drugs and acenocoumarol. ANTIVIR THER 2011;16 (2):249-252 [PubMed]
Hamers RL, Siwale M, Wallis CL, Labib M, van Hasselt R, Stevens WS, Schuurman R, Wensing AMJ, van Vugt M, Rinke de Wit TF, HIV-1 Drug Resistance Mutations Are Present in Six Percent of Persons Initiating Antiretroviral Therapy in Lusaka, Zambia. JAIDS-J ACQ IMM DEF 2010;55 (1):95-101 [PubMed]
Revell AD, Wang D, Harrigan R, Hamers RL, Wensing AMJ, DeWolf F, Nelson M, Geretti AM, Larder BA, Modelling response to HIV therapy without a genotype: an argument for viral load monitoring in resource-limited settings. J ANTIMICROB CHEMOTH 2010;65 (4):605-607 [PubMed]
Hamers RL, de Beer I, Kaura H, van Vugt M, Rinke de Wit TF, Oral Fluid HIV Rapid Testing in Southern Africa Is Suitable for Population-Level Surveillance But May Not Be So for Individual Diagnosis (Invited Response to Scott et al: Can Oral Fluid Testing Be Used to Replace Blood-Based HIV Rapid Testing to Improve Access to Diagnosis in South Africa?). JAIDS-J ACQ IMM DEF 2009;51 (5):648-649 [PubMed]
Hamers RL, Smit PW, Stevens W, Schuurman R, Rinke de Wit TF, Dried fluid spots for HIV type-1 viral load and resistance genotyping: a systematic review. ANTIVIR THER 2009;14 (5):619-629 [PubMed]
Hamers RL, de Beer IH, Kaura H, van Vugt M, Caparos L, Rinke de Wit TF, Diagnostic accuracy of 2 oral fluid-based tests for HIV surveillance in Namibia. JAIDS-J ACQ IMM DEF 2008;48 (1):116-118 [PubMed]
Hamers RL, Derdelinckx I, van Vugt M, Stevens W, Rinke de Wit TF, Chuurman R, The status of HIV-1 resistance to antiretroviral drugs in sub-Saharan Africa (vol 13, pg 625, 2008). ANTIVIR THER 2008;13 (8):1129
Hamers RL, Derdelinckx I, van Vugt M, Stevens W, Rinke de Wit TF, Schuurman R, The status of HIV-1 resistance to antiretroviral drugs in sub-Saharan Africa. ANTIVIR THER 2008;13 (5):625-639 [PubMed]
Hamers RL, Schuurman R, van Vugt M, Derdelinckx I, Rinke de Wit TF, Aidsbehandeling in Afrika: het risico van antiretrovirale resistentie. NED TIJDSCHR GENEESKD 2007;151 (48):2666-2671 [PubMed]
Key publications

Hamers RL. Drug-resistant HIV-1 in sub-Saharan Africa. Clinical and public health studies. s.l: s.n.; 2013. 365p. ISBN 9789461693297 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Rinke de Wit TF, Mugyenyi P; copromotor(s): van Vugt M, Schuurman R)
Gupta RK, Jordan MR, Sultan BJ, Hill A, Davis DHJ, Gregson J, Sawyer AW, Hamers RL, Ndembi N, Pillay D, Bertagnolio S, Global trends in antiretroviral resistance in treatment-naive individuals with HIV after rollout of antiretroviral treatment in resource-limited settings: a global collaborative study and meta-regression analysis. LANCET 2012;380 (9849):1250-1258 [PubMed]
Hamers RL, Schuurman R, Sigaloff KCE, Wallis CL, Kityo C, Siwale M, Mandaliya K, Ive P, Botes ME, Wellington M, Osibogun A, Wit FW, van Vugt M, Stevens WS, de Wit TFR, Effect of pretreatment HIV-1 drug resistance on immunological, virological, and drug-resistance outcomes of first-line antiretroviral treatment in sub-Saharan Africa: a multicentre cohort study. LANCET INFECT DIS 2012;12 (4):307-317 [PubMed]
Hamers RL, Wallis CL, Kityo C, Siwale M, Mandaliya K, Conradie F, Botes ME, Wellington M, Osibogun A, Sigaloff KCE, Nankya I, Schuurman R, Wit FW, Stevens WS, van Vugt M, de Wit TFR [Contributors: Mandaliya K, Abdallah S, Jao I, Dolan M, Schuurman R, Wensing AM, Hamers RL, Sigaloff KCE, Straatsma E, Wit FW, van Vugt M, Lange JM, Rinke de Wit TF, Osibogun A, Akanmu S, Botes ME, Conradie F, Ive P, Sanne I, Wallis CL, Letsoalo E, Stevens WS, Hardman M, Kityo C, Namayanja G, Nakatudde L, Nankya I, Kiconco M, Abwola M, Mugyenyi P, Ndembi N, Lyagoba F, Kaleebu P, Siwale M, Njovu C, Labib M, Menke J, Wellington M, Luthy R]] , HIV-1 drug resistance in antiretroviral-naive individuals in sub-Saharan Africa after rollout of antiretroviral therapy: a multicentre observational study. LANCET INFECT DIS 2011;11 (10):750-759 [PubMed]
Hamers RL, Kityo C, Lange JMA, de Wit TFR, Mugyenyi P, Global threat from drug resistant HIV in sub-Saharan Africa. BMJ-BRIT MED J 2012;344:e4159 [PubMed]


All Publications

Curriculum Vitae

Raph Hamers is a fellow infectious diseases and clinical immunology at the Academic Medical Center of the University of Amsterdam, and a post-doctoral research fellow at AIGHD. Raph Hamers trained as a medical doctor and internal medicine resident in the Netherlands. In 2003-2004 he was based at the Universidade Federal de Roraima in Brazil, working as a junior lecturer and researcher. In 2006 he joined PharmAccess Foundation in Amsterdam where he established and coordinated the Pan-African Studies to Evaluate HIV Resistance (PASER) network, which aim is to build regional capacity for the population-based assessment and prevention of HIV drug resistance.

In 2007, he co-founded the Affordable Resistance Test for Africa (ART-A) consortium, a public-private partnership that has developed a low-cost testing algorithm for HIV drug resistance. He obtained a post-graduate diploma in Epidemiology from the London School of Hygiene and Tropical Medicine in 2011 (With Distinction). His research at AIGHD, under mentorship of Prof. Tobias Rinke de Wit and Prof. Peter Mugyenyi, led toward the completion of his PhD at the University of Amsterdam in 2013 (Cum Laude). His PhD thesis is entitled “Drug-resistant HIV-1 in sub-Saharan Africa. Clinical and public health studies”. He serves as an Expert Consultant to the WHO Global HIV Drug Resistance Network.

In 2014, he received a prestigious 3 year post-doctoral Veni fellowship granted by the Netherlands Organization for Scientific Research through the Innovational Research Incentives Scheme. His research interests include the molecular epidemiology, diagnostic strategies and clinical management of drug-resistant HIV, HIV-induced chronic immune dysregulation, and models of optimal health care delivery in low and middle-income countries.

Research programmes

Prof. dr. T.F. Rinke de Wit PhD (Multi-disciplinary public health research in Africa)

Other research related activities
  • None reported
Current research funding
  • None reported