• Principal Investigator
  • Male

Prof. dr. W.A. van Gool

Position: Professor
Main activities: Patient care, Research
Specialisation: Neurology, especially the dementias
foto W.A. van Gool is one of the AMC Principal Investigators
Focus of research:

The research of Van Gool’s group focuses on impairments of cognition, affect and behaviour in brain diseases. Two major research lines focus on (A) the role of neuroinflammation in delirium, and (B) the role of vascular factors in causing neuropsychiatric abnormalities in elderly. This research seeks to combine studies in experimental animals with observational studies and clinical trials in patients.
 

The research line delirium in systemic inflammation addresses the interaction between the cholinergic system and activity of microglia in systemic infection. This project includes animal experiments, in vitro studies, neuropathological observations and a prospective cohort study of patients treated with a cholinesterase inhibitor.
 

The research line prevention of dementia includes a long-term project investigating the effects of intensive vascular care in 3533 older persons. During 6-8 years of follow-up various forms of functional impairment will be studies over time in relation to baseline characteristics, genetic markers and changes in cardiovascular risk profile in the course of time.
 

Both research lines share the common goal of preventing functional decline as a consequence of frequently occurring brain diseases in the elderly.
 

AMC themes: Neurological & Psychiatric Disorders
Departments: Neurology
Beishuizen CRL, Coley N, Moll van Charante EP, van Gool WA, Richard E, Andrieu S, Determinants of Dropout and Nonadherence in a Dementia Prevention Randomized Controlled Trial: The Prevention of Dementia by Intensive Vascular Care Trial. J AM GERIATR SOC 2017;65 (7):1505-1513 [PubMed]
Hanemaaijer JI, Wijnen VJM, van Gool WA, Het electroencefalogram bij delier bij dementie (DBD)]. TIJDSCHR GERONTOL GERIATR 2017;48 (4):153-159 [PubMed]
Jongstra S. eHealth in cardiovascular risk management to prevent cognitive decline. S.l.: s.n.; 2017. 232p. ISBN 978-94-6299-678-6 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Gool WA; copromotor(s): Richard E, Moll van Charante EP)
van Bussel EF, Richard E, Arts DL, Nooyens ACJ, Coloma PM, de Waal MWM, van den Akker M, Biermans MCJ, Nielen MMJ, van Boven K, Smeets H, Matthews FE, Brayne C, Busschers WB, van Gool WA, Moll van Charante EP, Dementia incidence trend over 1992-2014 in the Netherlands: Analysis of primary care data. PLOS MED 2017;14 (3):e1002235 [PubMed]
van Dalen JW, Moll van Charante EP, Caan MWA, Scheltens P, Majoie CBLM, Nederveen AJ, van Gool WA, Richard E, Effect of Long-Term Vascular Care on Progression of Cerebrovascular Lesions: Magnetic Resonance Imaging Substudy of the PreDIVA Trial (Prevention of Dementia by Intensive Vascular Care). STROKE 2017;48 (7):1842-1848 [PubMed]
van Middelaar T, van Vught LA, van Charante EPM, Eurelings LSM, Ligthart SA, van Dalen JW, van den Born BJH, Richard E, van Gool WA, Lower dementia risk with different classes of antihypertensive medication in older patients. J HYPERTENS 2017;35 (10):2095-2101 [PubMed]
Beishuizen CRL, Stephan BCM, van Gool WA, Brayne C, Peters RJG, Andrieu S, Kivipelto M, Soininen H, Busschers WB, Moll van Charante EP, Richard E, Web-Based Interventions Targeting Cardiovascular Risk Factors in Middle-Aged and Older People: A Systematic Review and Meta-Analysis. J MED INTERNET RES 2016;18 (3):e55 [PubMed]
Beishuizen CRL, van Gool WA, Busschers WB, Peters RJG, Moll van Charante EP, Richard E, Internetinterventies voor cardiovasculaire risicofactoren bij ouderen. NED TIJDSCHR GENEESKD 2016;160:D581 [PubMed]
Eurelings LSM. Vascular factors in dementia and apathy. S.l.: s.n.; 2016. 257p. ISBN 978-94-6233-376-5 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Gool WA; copromotor(s): Richard E, Moll van Charante EP)
Eurelings LSM, Jaccard J, Moll van Charante EP, Eikelenboom P, Ligthart SA, van Gool WA, Richard E, The mediating role of cardiovascular risk factors in the relationship between symptoms of apathy and incident cardiovascular disease in community-dwelling older individuals. INT PSYCHOGERIATR 2016;28 (4):669-679 [PubMed]
Moll van Charante EP, Richard E, Eurelings LS, van Dalen JW, Ligthart SA, van Bussel EF, Hoevenaar-Blom MP, Vermeulen M, van Gool WA, Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial. LANCET 2016;388 (10046):797-805 [PubMed]
Richard E, Jongstra S, Soininen H, Brayne C, Moll van Charante EP, Meiller Y, van der Groep B, Beishuizen CRL, Mangialasche F, Barbera M, Ngandu T, Coley N, Guillemont J, Savy S, Dijkgraaf MGW, Peters RJG, van Gool WA, Kivipelto M, Andrieu S, Healthy Ageing Through Internet Counselling in the Elderly: the HATICE randomised controlled trial for the prevention of cardiovascular disease and cognitive impairment. BMJ OPEN 2016;6 (6):e010806 [PubMed]
van Dalen JW, Caan MWA, van Gool WA, Richard E, Neuropsychiatric symptoms of cholinergic deficiency occur with degradation of the projections from the nucleus basalis of Meynert. BRAIN IMAGING BEHAV 2016;ahead of print [PubMed]
van Dalen JW, Mutsaerts HJMM, Nederveen AJ, Vrenken H, Steenwijk MD, Caan MWA, Majoie CBLM, van Gool WA, Richard E, White Matter Hyperintensity Volume and Cerebral Perfusion in Older Individuals with Hypertension Using Arterial Spin-Labeling. AM J NEURORADIOL 2016;37 (10):1824-1830 [PubMed]
van Sandwijk MS, ten Berge IJM, Majoie CBLM, Caan MWA, de Sonneville LMJ, van Gool WA, Bemelman FJ, Cognitive Changes in Chronic Kidney Disease and After Transplantation. TRANSPLANTATION 2016;100 (4):734-742 [PubMed]
Wijnia JW, Oudman E, van Gool WA, Wierdsma AI, Bresser EL, Bakker J, van de Wiel A, Mulder CL, Severe Infections are Common in Thiamine Deficiency and May be Related to Cognitive Outcomes: A Cohort Study of 68 Patients With Wernicke-Korsakoff Syndrome. PSYCHOSOMATICS 2016;57 (6):624-633 [PubMed]
Wouters H, van Campen JPCM, Appels BA, Beijnen JH, Zwinderman AH, van Gool WA, Schmand B, Individualized evaluation of cholinesterase inhibitors effects in dementia with adaptive cognitive testing. INT J METH PSYCH RES 2016;25 (3):190-198 [PubMed]
den Brok MGHE, van Dalen JW, van Gool WA, Moll van Charante EP, de Bie RMA, Richard E, Apathy in Parkinson's disease: A systematic review and meta-analysis. MOVEMENT DISORD 2015;30 (6):759-769 [PubMed]
Eurelings LSM, Richard E, Eikelenboom P, van Gool WA, Moll van Charante EP, Low-grade inflammation differentiates between symptoms of apathy and depression in community-dwelling older individuals. INT PSYCHOGERIATR 2015;27 (4):639-647 [PubMed]
Hoogland ICM, Houbolt C, van Westerloo DJ, van Gool WA, van de Beek D, Systemic inflammation and microglial activation: systematic review of animal experiments. J NEUROINFLAMM 2015;12 (1):114 [PubMed]
Jans IS, Oudewortel L, Brandt PM, van Gool WA, Severe, Persistent and Fatal Delirium in Psychogeriatric Patients Admitted to a Psychiatric Hospital. DEMENT GERIATR COG D 2015;5 (2):253-264 [PubMed]
Ligthart SA. Cardiovascular prevention in older people: The preDIVA trial. S.l.: s.n.; 2015. 169p. ISBN 978-94-6169-623-6 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Gool WA, van Weert HCPM; copromotor(s): Moll van Charante EP, Richard E)
van Dalen JW, Scuric EEM, van Veluw SJ, Caan MWA, Nederveen AJ, Biessels GJ, van Gool WA, Richard E, Cortical microinfarcts detected in vivo on 3 Tesla MRI: clinical and radiological correlates. STROKE 2015;46 (1):255-257 [PubMed]
van Gool WA, Richard E, Predicting dementia. BMJ-BRIT MED J 2015;350:h2994 [PubMed]
Westhoff D, Witlox J, van Aalst C, Scholtens RM, de Rooij SE, van Munster BC, de Jonghe JFM, Houdijk APJ, Eikelenboom P, van Westerloo DJ, van de Beek D, van Gool WA, Koenderman L, Preoperative protein profiles in cerebrospinal fluid in elderly hip fracture patients at risk for delirium: A proteomics and validation study. BBA CLIN 2015;4:115-122 [PubMed]
Eurelings LSM, Ligthart SA, van Dalen JW, Moll van Charante EP, van Gool WA, Richard E, Apathy is an independent risk factor for incident cardiovascular disease in the older individual: a population-based cohort study. INT J GERIATR PSYCH 2014;29 (5):454-463 [PubMed]
Schmand B, Rienstra A, Tamminga H, Richard E, van Gool WA, Caan MWA, Majoie CB, Responsiveness of magnetic resonance imaging and neuropsychological assessment in memory clinic patients. J ALZHEIMERS DIS 2014;40 (2):409-418 [PubMed]
Richard E, Schmand BA, Eikelenboom P, van Gool WA, MRI and cerebrospinal fluid biomarkers for predicting progression to Alzheimer's disease in patients with mild cognitive impairment: a diagnostic accuracy study. BMJ OPEN 2013;3 (6):e002541 [PubMed]
Rienstra A, Groot PFC, Spaan PEJ, Majoie CBLM, Nederveen AJ, Walstra GJM, de Jonghe JFM, van Gool WA, Olabarriaga SD, Korkhov VV, Schmand B, Symptom validity testing in memory clinics: Hippocampal-memory associations and relevance for diagnosing mild cognitive impairment. J CLIN EXP NEUROPSYC 2013;35 (1):59-70 [PubMed]
Slor CJ. The wave called delirium, from onset to consequences. s.l.: s.n.; 2013. 160p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Gool WA, Eikelenboom P; copromotor(s): de Jonghe JFM, Jansen RWMM)
Slor CJ, Witlox J, Adamis D, Meagher DJ, van der Ploeg T, Jansen RWMM, van Stijn MFM, Houdijk APJ, van Gool WA, Eikelenboom P, de Jonghe JFM, Predicting delirium duration in elderly hip-surgery patients: does early symptom profile matter?. CURR GERONTOL GERIATR RES 2013;2013:962321 [PubMed]
Slor CJ, Witlox J, Jansen RWMM, Adamis D, Meagher DJ, Tieken E, Houdijk APJ, van Gool WA, Eikelenboom P, de Jonghe JFM, Affective functioning after delirium in elderly hip fracture patients. INT PSYCHOGERIATR 2013;25 (3):445-455 [PubMed]
van Dalen JW, Moll van Charante EP, Nederkoorn PJ, van Gool WA, Richard E, Poststroke apathy. STROKE 2013;44 (3):851-860 [PubMed]
Westhoff D, Witlox J, Koenderman L, Kalisvaart KJ, de Jonghe JFM, van Stijn MFM, Houdijk APJ, Hoogland ICM, Maclullich AMJ, van Westerloo DJ, van de Beek D, Eikelenboom P, van Gool WA, Preoperative cerebrospinal fluid cytokine levels and the risk of postoperative delirium in elderly hip fracture patients. J NEUROINFLAMM 2013;10 (1):122 [PubMed]
Witlox J, Slor CJ, Jansen RWMM, Kalisvaart KJ, van Stijn MFM, Houdijk APJ, Eikelenboom P, van Gool WA, de Jonghe JFM, The neuropsychological sequelae of delirium in elderly patients with hip fracture three months after hospital discharge. INT PSYCHOGERIATR 2013;25 (9):1521-1531 [PubMed]
Eikelenboom P, Hoozemans JJM, Veerhuis R, van Exel E, Rozemuller AJM, van Gool WA, Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer's disease. ALZHEIMERS RES THER 2012;4 (3):15 [PubMed]
Eikelenboom P, van Exel E, Veerhuis R, Rozemuller AJM, van Gool WA, Hoozemans JJM, Innate Immunity and the Etiology of Late-Onset Alzheimer's Disease. NEURODEGENER DIS 2012;10 (1-4):271-273 [PubMed]
Jansen C, Parchi P, Capellari S, Ibrahim-Verbaas CA, Schuur M, Strammiello R, Corrado P, Bishop MT, van Gool WA, Verbeek MM, Baas F, van Saane W, Spliet WGM, Jansen GH, van Duijn CM, Rozemuller AJM, Human Prion Diseases in The Netherlands (1998-2009): Clinical, Genetic and Molecular Aspects. PLOS ONE 2012;7 (4):e36333 [PubMed]
Ligthart SA, Richard E, Fransen NL, Eurelings LSM, Beem L, Eikelenboom P, van Gool WA, Moll van Charante EP, Association of Vascular Factors With Apathy in Community-Dwelling Elderly Individuals. ARCH GEN PSYCHIAT 2012;69 (6):636-642 [PubMed]
Ligthart SA, Richard E, van Gool WA, Moll van Charante EP, Cardiovascular risk management in community-dwelling elderly: opportunities for prevention. EUR J PREV CARDIOL 2012;19 (6):1365-1372 [PubMed]
Richard E, Andrieu S, Solomon A, Mangialasche F, Ahtiluoto S, Moll van Charante EP, Coley N, Fratiglioni L, Neely AS, Vellas B, van Gool WA, Kivipelto M, Methodological challenges in designing dementia prevention trials - The European Dementia Prevention Initiative (EDPI). J NEUROL SCI 2012;322 (1-2):64-70 [PubMed]
Richard E, Moll van Charante EP, van Gool WA, Vascular Risk Factors as Treatment Target to Prevent Cognitive Decline. J ALZHEIMERS DIS 2012;32 (3):733-740 [PubMed]
Richard E, Schmand B, Eikelenboom P, Westendorp RG, van Gool WA, The Alzheimer Myth and Biomarker Research in Dementia. J ALZHEIMERS DIS 2012;31 (3):S203-S209 [PubMed]
Richard E, Schmand B, Eikelenboom P, Yang SC, Ligthart SA, Moll van Charante EP, van Gool WA, Symptoms of Apathy Are Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease in Non-Depressed Subjects. DEMENT GERIATR COGN 2012;33 (2-3):204-209 [PubMed]
Schmand B, Eikelenboom P, van Gool WA, Value of Diagnostic Tests to Predict Conversion to Alzheimer's Disease in Young and Old Patients with Amnestic Mild Cognitive Impairment. J ALZHEIMERS DIS 2012;29 (3):641-648 [PubMed]
Witlox J. Delirium in the elderly: biomarkers and outcomes. s.l.: s.n.; 2012. 176p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Gool WA, Eikelenboom P; copromotor(s): de Jonghe JFM, Kalisvaart CJ)
Wouters H, Appels B, van der Flier WM, van Campen J, Klein M, Zwinderman AH, Schmand B, van Gool WA, Scheltens P, Lindeboom R, Improving the Accuracy and Precision of Cognitive Testing in Mild Dementia. J INT NEUROPSYCH SOC 2012;18 (2):314-322 [PubMed]
Eikelenboom P, Veerhuis R, van Exel E, Hoozemans JJM, Rozemuller AJM, van Gool WA, The early involvement of the innate immunity in the pathogenesis of late-onset Alzheimer's disease: neuropathological, epidemiological and genetic evidence. CURR ALZHEIMER RES 2011;8 (2):142-150 [PubMed]
Hoozemans JJM, Rozemuller AJM, van Haastert ES, Eikelenboom P, van Gool WA, Neuroinflammation in Alzheimer's disease wanes with age. J NEUROINFLAMM 2011;8 (1):171 [PubMed]
Jansen C, Voet W, Head MW, Parchi P, Yull H, Verrips A, Wesseling P, Meulstee J, Baas F, van Gool WA, Ironside JW, Rozemuller AJM, A novel seven-octapeptide repeat insertion in the prion protein gene (PRNP) in a Dutch pedigree with Gerstmann-Sträussler-Scheinker disease phenotype: comparison with similar cases from the literature. ACTA NEUROPATHOL 2011;121 (1):59-68 [PubMed]
Kat MG, de Jonghe JF, Vreeswijk R, van der Ploeg T, van Gool WA, Eikelenboom P, Kalisvaart KJ, Mortality associated with delirium after hip-surgery: a 2-year follow-up study. AGE AGEING 2011;40 (3):312-318 [PubMed]
Schmand B, Eikelenboom P, van Gool WA, Value of neuropsychological tests, neuroimaging, and biomarkers for diagnosing Alzheimer's disease in younger and older age cohorts. J AM GERIATR SOC 2011;59 (9):1705-1710 [PubMed]
Slor CJ, de Jonghe JFM, Vreeswijk R, Groot E, Ploeg TVD, van Gool WA, Eikelenboom P, Snoeck M, Schmand B, Kalisvaart KJ, Anesthesia and Postoperative Delirium in Older Adults Undergoing Hip Surgery. J AM GERIATR SOC 2011;59 (7):1313-1319 [PubMed]
van Eijk MMJ, van Gool WA, Slooter AJC, Cholinesterase inhibitor treatment in patients with delirium Reply. LANCET 2011;377 (9769):901
van Eijk MM, van den Boogaard M, van Marum RJ, Benner P, Eikelenboom P, Honing ML, van der Hoven B, Horn J, Izaks GJ, Kalf A, Karakus A, Klijn IA, Kuiper MA, de Leeuw FE, de Man T, van der Mast RC, Osse RJ, de Rooij SE, Spronk PE, van der Voort PH, van Gool WA, Slooter AJ, Routine use of the confusion assessment method for the intensive care unit: a multicenter study. AM J RESP CRIT CARE 2011;184 (3):340-344 [PubMed]
Vansteenkiste I, van Gool WA, Hofstee DJ, Tijssen MAJ, Conversion disorder as initial diagnosis in pantothenate kinase associated neurodegeneration. J NEUROL 2011;258 (1):152-154 [PubMed]
Witlox J, Kalisvaart KJ, de Jonghe JFM, Verwey NA, van Stijn MFM, Houdijk APJ, Traast HS, Maclullich AMJ, van Gool WA, Eikelenboom P, Cerebrospinal fluid β-amyloid and tau are not associated with risk of delirium: a prospective cohort study in older adults with hip fracture. J AM GERIATR SOC 2011;59 (7):1260-1267 [PubMed]
Wouters H. Towards adaptive cognitive testing in dementia. s.l.: s.n.; 2011. 188p. ISBN 9789064644443 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Zwinderman AH, Schmand B; copromotor(s): Lindeboom R, van Gool WA)
Wouters H, van Campen J, Appels B, Lindeboom R, Buiter M, de Haan RJ, Zwinderman AH, van Gool WA, Schmand B, Does adaptive cognitive testing combine efficiency with precision? Prospective findings. J ALZHEIMERS DIS 2011;25 (4):595-603 [PubMed]
Coppus AMW, Evenhuis HM, Verberne GJ, Visser FE, Eikelenboom P, van Gool WA, Janssens ACJW, van Duijn CM, Early Age at Menopause is Associated with Increased risk of Dementia and Mortality in Women with Down Syndrome. J ALZHEIMERS DIS 2010;19 (2):545-550 [PubMed]
Eikelenboom P, van Exel E, Hoozemans JJM, Veerhuis R, Rozemuller AJM, van Gool WA, Neuroinflammation - An Early Event in Both the History and Pathogenesis of Alzheimer's Disease. NEURODEGENER DIS 2010;7 (1-3):38-41 [PubMed]
Eurelings LSM, Richard E, Carrano A, Eikelenboom P, van Gool WA, Rozemuller AJM, Dyshoric capillary cerebral amyloid angiopathy mimicking Creutzfeldt-Jakob disease. J NEUROL SCI 2010;295 (1-2):131-134 [PubMed]
Jansen C, Head MW, van Gool WA, Baas F, Yull H, Ironside JW, Rozemuller AJM, The first case of protease-sensitive prionopathy (PSPr) in The Netherlands: a patient with an unusual GSS-like clinical phenotype. J NEUROL NEUROSUR PS 2010;81 (9):1052-1055 [PubMed]
Jansen C, Parchi P, Capellari S, Vermeij AJ, Corrado P, Baas F, Strammiello R, van Gool WA, van Swieten JC, Rozemuller AJM, Prion protein amyloidosis with divergent phenotype associated with two novel nonsense mutations in PRNP. ACTA NEUROPATHOL 2010;119 (2):189-197 [PubMed]
Ligthart SA, Moll van Charante EP, van Gool WA, Richard E, Treatment of cardiovascular risk factors to prevent cognitive decline and dementia: a systematic review. VASC HEALTH RISK MANAG 2010;6:775-785 [PubMed]
Richard E. Vascular factors in dementia - prevention and pathology. s.l.: s.n.; 2010. 139p. ISBN 9789080732964 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Gool WA, Eikelenboom P; copromotor(s): )
Richard E, Carrano A, Hoozemans JJ, van Horssen J, van Haastert ES, Eurelings LS, de Vries HE, Thal DR, Eikelenboom P, van Gool WA, Rozemuller AJM, Characteristics of Dyshoric Capillary Cerebral Amyloid Angiopathy. J NEUROPATH EXP NEUR 2010;69 (11):1158-1167 [PubMed]
Richard E, Gouw AA, Scheltens P, van Gool WA, Vascular Care in Patients With Alzheimer Disease With Cerebrovascular Lesions Slows Progression of White Matter Lesions on MRI The Evaluation of Vascular Care in Alzheimer's Disease (EVA) Study. STROKE 2010;41 (3):554-556 [PubMed]
Richard E, Ligthart SA, Moll van Charante EP, van Gool WA, METHODOLOGICAL ISSUES IN A CLUSTER-RANDOMIZED TRIAL TO PREVENT DEMENTIA BY INTENSIVE VASCULAR CARE. J NUTR HEALTH AGING 2010;14 (4):315-317 [PubMed]
Richard E, Ligthart SA, Moll van Charante EP, van Gool WA, Vascular risk factors and dementia - towards prevention strategies. NETH J MED 2010;68 (10):284-290 [PubMed]
Richard E, van Gool WA, Response letter to dr. Dae hyun kim. J AM GERIATR SOC 2010;58 (1):186-187 [PubMed]
Richard E, van Gool WA, There are two types of disease. BMJ-BRIT MED J 2010;341:c6327 [PubMed]
Richard E, van Gool WA, Hoozemans JJM, An Haastert ESV, Eikelenboom P, Rozemuller AJM, van de Berg WDJ, Morphometric Changes in the Cortical Microvascular Network in Alzheimer's Disease. J ALZHEIMERS DIS 2010;22 (3):811-818 [PubMed]
Schmand B, Huizenga HM, van Gool WA, Meta-analysis of CSF and MRI biomarkers for detecting preclinical Alzheimer's disease. PSYCHOL MED 2010;40 (1):135-145 [PubMed]
Thoonsen H, Richard E, Bentham P, Gray R, van Geloven N, de Haan RJ, van Gool WA, Nederkoorn PJ, Aspirin in Alzheimer's Disease Increased Risk of Intracerebral Hemorrhage: Cause for Concern?. STROKE 2010;41 (11):2690-2692 [PubMed]
van Eijk MMJ, Roes KCB, Honing MLH, Kuiper MA, Karakus A, van der Jagt M, Spronk PE, van Gool WA, van der Mast RC, Kesecioglu J, Slooter AJC, Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double-blind, placebo-controlled randomised trial. LANCET 2010;376 (9755):1829-1837 [PubMed]
van Gool WA, van de Beek D, Eikelenboom P, Systemic infection and delirium: when cytokines and acetylcholine collide. LANCET 2010;375 (9716):773-775 [PubMed]
Witlox J, Eurelings LSM, de Jonghe JFM, Kalisvaart KJ, Eikelenboom P, van Gool WA, Delirium in Elderly Patients and the Risk of Postdischarge Mortality, Institutionalization, and Dementia A Meta-analysis. JAMA-J AM MED ASSOC 2010;304 (4):443-451 [PubMed]
Wouters H, Appels B, van Campen J, Lindeboom R, Buiter M, Zwinderman AH, van Gool WA, Schmand B, Adaptive testing combines precision with brevity in the grading of cognitive impairment. BEHAV NEUROL 2010;23 (4):181-183 [PubMed]
Wouters H, van Gool WA, Schmand B, Zwinderman AH, Lindeboom R, Three sides of the same coin: measuring global cognitive impairment with the MMSE, ADAS-cog and CAMCOG. INT J GERIATR PSYCH 2010;25 (8):770-779 [PubMed]
Jansen C, Schuur M, Spliet WGM, van Gool WA, van Duijn CM, Rozemuller AJM, Elf jaar obducties wegens de ziekte van Creutzfeldt-Jakob in Nederland. NED TIJDSCHR GENEESKD 2009;153:A172 [PubMed]
Kat MG. The neuropsychiatry of dementia. Psychometrics, clinical implications and outcome. s.l.: s.n.; 2009. 192p. ISBN 9789073118126 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Eikelenboom P, van Gool WA; copromotor(s): de Jonghe JFM, Kalisvaart CJ)
Post B, van Gool WA, Tijssen MAJ, Transient Parkinsonism in isolated extrapontine myelinolysis. NEUROL SCI 2009;30 (4):325-328 [PubMed]
Richard E, Kuiper R, Dijkgraaf MGW, van Gool WA, Vascular care in patients with Alzheimer's disease with cerebrovascular lesions-a randomized clinical trial. J AM GERIATR SOC 2009;57 (5):797-805 [PubMed]
Richard E, van den Heuvel E , Moll van Charante EP, Achthoven L, Vermeulen M, Bindels PJ, van Gool WA, Prevention of dementia by intensive vascular care (PreDIVA): a cluster-randomized trial in progress. ALZ DIS ASSOC DIS 2009;23 (3):198-204 [PubMed]
Schuur M, Jansen C, Rozemuller AJM, van Gool WA, van Duijn CM, Humane spongiforme encefalopathieën in Nederland. NED TIJDSCHR GENEESKD 2009;153:A173 [PubMed]
van Dam F, van Gool WA, Hyperhomocysteinemia and Alzheimer's disease: A systematic review. ARCH GERONTOL GERIAT 2009;48 (3):425-430 [PubMed]
Vermeulen M, van Gool WA, Uitzonderlijk lange overleving. NED TIJDSCHR GENEESKD 2009;153 (7):282-285 [PubMed]
Wouters H, de Koning I, Zwinderman AH, van Gool WA, Schmand B, Buiter M, Lindeboom R, Adaptive cognitive testing in cerebrovascular disease and vascular dementia. DEMENT GERIATR COGN 2009;28 (5):486-492 [PubMed]
Wouters H, Zwinderman AH, van Gool WA, Schmand B, Lindeboom R, Adaptive cognitive testing in dementia. INT J METH PSYCH RES 2009;18 (2):118-127 [PubMed]
Coppus AMW, Evenhuis HM, Verberne GJ, Visser FE, Arias-Vasquez A, Sayed-Tabatabaei FA, Vergeer-Drop J, Eikelenboom P, van Gool WA, van Duijn CM, The impact of apolipoprotein E on dementia in persons with Down's syndrome. NEUROBIOL AGING 2008;29 (6):828-835 [PubMed]
Coppus AMW, Evenhuis HM, Verberne GJ, Visser FE, Oostra BA, Eikelenboom P, van Gool WA, Janssens ACJW, van Duijn CM, Survival in Elderly Persons with Down Syndrome. J AM GERIATR SOC 2008;56 (12):2311-2316 [PubMed]
Eikelenboom P, Schmand BA, van der Mast RC, van Gool WA. Delirium, dementie en andere cognitieve stoornissen in: Vandereycken W, Hoogduin CAL, Emmelkamp PMG, editors. Handboek psychopathologie. Deel 1. Basisbegrippen. vierde druk. Houten: Van Loghum; 2008., p. 63-106
Eikelenboom P, Veerhuis R, Familian A, Hoozemans JJM, van Gool WA, Rozemuller AJM, Neuroinflammation in plaque and vascular beta-amyloid disorders: clinical and therapeutic implications. NEURODEGENER DIS 2008;5 (3-4):190-193 [PubMed]
Kat MG, Vreeswijk R, de Jonghe JFM, van der Ploeg T, van Gool WA, Eikelenboom P, Kalisvaart KJ, Long-term cognitive outcome of delirium in elderly hip surgery patients. A prospective matched controlled study over two and a half years. DEMENT GERIATR COGN 2008;26 (1):1-8 [PubMed]
Kat MG, Zuidema SU, van der Ploeg T, Kalisvaart KJ, van Gool WA, Eikelenboom P, de Jonghe JFM, Reasons for psychiatric consultation referrals in Dutch nursing home patients with dementia: a comparison with normative data on prevalence of neuropsychiatric symptoms. INT J GERIATR PSYCH 2008;23 (10):1014-1019 [PubMed]
Lemstra AW. Cholinergic deficiency and inflammation in cognitive dysfunction. s.l.: s.n.; 2008. 135p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Gool WA; copromotor(s): Eikelenboom P)
Lemstra AW, Kalisvaart KJ, Vreeswijk R, van Gool WA, Eikelenboom P, Pre-operative inflammatory markers and the risk of postoperative delirium in elderly patients. INT J GERIATR PSYCH 2008;23 (9):943-948 [PubMed]
Lemstra AW, Kuiper RB, Schmand B, van Gool WA, Identification of responders to rivastigmine: a prospective cohort study. DEMENT GERIATR COGN 2008;25 (1):60-66 [PubMed]
van Gool WA, Richard E, Geen bewijs voor effectiviteit cholinesterase remmers bij vroege stadia van de ziekte van Alzheimer. TIJDSCHR NEUROL NEUROCHIR 2008;109:297-300
Wouters H, van Gool WA, Schmand B, Lindeboom R, Revising the ADAS-cog for a more accurate assessment of cognitive impairment. ALZ DIS ASSOC DIS 2008;22 (3):236-244 [PubMed]
Lemstra AW, in't Woud JCMG, Hoozemans JJM, van Haastert ES, Rozemuller AJM, Eikelenboom P, van Gool WA, Microglia activation in sepsis: a case-control study. J NEUROINFLAMM 2007;4:4 [PubMed]
Lemstra AW, Richard E, van Gool WA, Cholinesterase inhibitors in dementia: yes, no, or maybe?. AGE AGEING 2007;36 (6):625-627 [PubMed]
Meesters PD, van Gool WA. Neuropsychiatrie in de praktijk. Maarssen: Elsevier Gezondheidszorg; 2007. 282p. ISBN 9879035229143
Coppus A, Evenhuis H, Verberne GJ, Visser F, van Gool P, Eikelenboom P, van Duijin C, Dementia and mortality in persons with Down's syndrome. J INTELL DISABIL RES 2006;50 (Part 10):768-777 [PubMed]
Eikelenboom P, Veerhuis R, Scheper W, Rozemuller AJM, van Gool WA, Hoozemans JJM, The significance of neuroinflammation in understanding Alzheimer's disease. J NEURAL TRANSM 2006;113 (11):1685-1695 [PubMed]
Kalisvaart KJ, de Jonghe JFM, Bogaards MJ, Vreeswijk R, Egberts TCG, Eikelenboom P, van Gool WA, Response letters to Drs. Wang, and Seitz and Gill. J AM GERIATR SOC 2006;54 (5):861-863
Kalisvaart KJ, Vreeswijk R, de Jonghe JFM, van der Ploeg T, van Gool WA, Eikelenboom P, Risk factors and prediction of postoperative delirium in elderly hip-surgery patients: implementation and validation of a medical risk factor model. J AM GERIATR SOC 2006;54 (5):817-822 [PubMed]
Lemstra AW, Schoenmaker N, Rozemuller-Kwakkel AJM, van Gool WA, The association of neuroleptic sensitivity in Lewy body disease with a false positive clinical diagnosis of Creutzfeldt-Jakob disease. INT J GERIATR PSYCH 2006;21 (11):1031-1035 [PubMed]
Richard E, van Gool WA, Cholinesteraseremmers bij dementie: een wankel evenwicht tussen werkzaamheid en veiligheid. NED TIJDSCHR GENEESKD 2006;150 (10):530-532 [PubMed]
van Gool WA, Can we prevent, delay, or shorten the course of dementia?. PLOS MED 2006;3 (10):e430-1718 [PubMed]
van Gool WA, Multiple-level studies are needed to assess the true value of diagnostic tests for dementia. ARCH NEUROL-CHICAGO 2006;63 (1):142-143 [PubMed]
van Gool WA, Stam CJ, Steenhoek A, Hagemeijer A, Richtlijn 'Diagnostiek en medicamenteuze behandeling van dementie'. NED TIJDSCHR GENEESKD 2006;150 (15):839-843 [PubMed]
Eikelenboom P, Hoozemans JJM, Rozemuller JM, Veerhuis R, van Gool WA. Neuroinflammatory mechanisms are involved in th early steps of the pathological cascade in Alzheimer's disease in: Hanin I, Cacabelos R, Fisher A, editors. Recent progress in Alzheimer's and Parkinson's disease. London/New York: Taylor and Francis; 2005., p. 145-151
Kalisvaart CJ. Primary orevention of delirium in the elderly. S.l.: s.n.; 2005. 159p. ISBN 9789090197999 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Eikelenboom P, van Gool WA; copromotor(s): de Jonghe JFM)
Kalisvaart KJ, de Jonghe JFM, Bogaards MJ, Vreeswijk R, Egberts TCG, Burger BJ, Eikelenboom P, van Gool WA, Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: A randomized placebo-controlled study. J AM GERIATR SOC 2005;53 (10):1658-1666 [PubMed]
Rozemuller AJM, van Gool WA, Eikelenboom P, The neuroinflammatory response in plaques and amyloid angiopathy in Alzheimer's disease: therapeutic implications. CURR DRUG TARGETS 2005;4 (3):223-233 [PubMed]
Arias Vásquez A, Sleegers K, Dekker MCJ, van Gool WA, van Swieten JC, Aulchenko YS, Oostra BA, van Duijn CM, A deletion in DJ-1 and the risk of dementia - a population-based survey. NEUROSCI LETT 2004;372 (3):196-199 [PubMed]
Eikelenboom P, van Gool WA, Neuroinflammatory perspectives on the two faces of Alzheimer's disease. J NEURAL TRANSM 2004;111 (3):281-294 [PubMed]
Schoenmaker N, van Gool WA, The age gap between patients in clinical studies and in the general population: a pitfall for dementia research. LANCET NEUROL 2004;3 (10):627-630 [PubMed]
Sleegers K, Roks G, Theuns J, Aulchenko YS, Rademakers R, Cruts M, van Gool WA, van Broeckhoven C, Heutink P, Oostra BA, van Swieten JC, van Duijn CM, Familial clustering and genetic risk for dementia in a genetically isolated Dutch population. BRAIN 2004;127 (Part 7):1641-1649 [PubMed]
van Gool WA, De standaard 'Dementie' (tweede herziening) van het Nederlands Huisartsen Genootschap; reactie vanuit de neurologie. NED TIJDSCHR GENEESKD 2004;148 (24):1179-1181 [PubMed]
Lemstra AW, Eikelenboom P, van Gool WA, Het cholinerge deficientiesyndroom als indicatie voor cholinesteraseremmers. NED TIJDSCHR GENEESKD 2003;147 (45):2201-2203 [PubMed]
Lemstra AW, Eikelenboom P, van Gool WA, The cholinergic deficiency syndrome and its therapeutic implications. GERONTOLOGY 2003;49 (1):55-60 [PubMed]
van Gool WA, Aisen PS, Eikelenboom P, Anti-inflammatory therapy in Alzheimer's disease: is hope still alive?. J NEUROL 2003;250 (7):788-792 [PubMed]
van Gool WA, Eikelenboom P, Memantine bij dementie. NED TIJDSCHR GENEESKD 2003;147 (43):2101-2102 [PubMed]
van Gool WA, Lemstra AW, Cholinesterase inhibitors for Alzheimer disease. JAMA-J AM MED ASSOC 2003;289 (18):2359-2359; author reply 2361 [PubMed]
Croes EA, van Gool WA, Jansen GH, van Duijn CM, Ziekte van Creutzfeldt-Jakob: diagnostiek, incidentie, preventie en behandeling. NED TIJDSCHR GENEESKD 2002;146 (16):750-754 [PubMed]
de Beaufort ID, Gevers JKM, van Gool WA, Swaab DF, et al -. Dementie. Advies van een commissie van de Gezondheidsraad aan de minister van VWS. S.l.: s.n.; 2002. 214p. (Adviezen van een commissie van de Gezondheidsraad; 2002/04)
Eikelenboom P, Bate C, van Gool WA, Hoozemans JJM, Rozemuller JM, Veerhuis R, Williams A, Neuroinflammation in Alzheimer's disease and prion disease. GLIA 2002;40 (2):232-239 [PubMed]
Lemstra AW, Eikelenboom P, Meijer EW, van Gool WA, Nieuwe therapeutische benadering van amyloïdose: vooralsnog geen implicaties voor patiënten met de ziekte van Alzheimer. NED TIJDSCHR GENEESKD 2002;146 (37):1720-1723 [PubMed]
Lemstra AW, van Gool WA, De nieuwe variant van de ziekte van Creutzfeldt-Jakob. NED TIJDSCHR NEUROL 2002;- (6):449-454
Lemstra E, van Gool WA, Prionziekten. NEUROPRAXIS 2002;- (6):17-21
Richard E, Walstra GJ, van Campen J, Vissers E, van Gool WA, Rivastigmine bij de ziekte van Alzheimer; evaluatie van de eerste ervaringen en van gestructureerde effectmeting. NED TIJDSCHR GENEESKD 2002;146 (1):24-27 [PubMed]
van Gool WA, Cholinesteraseremmers in de spreekkamer. PSYCHOPRAXIS 2002;4 (6):264-266
van Gool WA, Medische misvattingen: 'De ziekte van Alzheimer is één ziekte'. MED CONTACT 2002;57 (9):327
van Gool WA. Therapie bij dementie in: Chel V.G M,, Vliet Vlieland CW, editors. Ontwikkelingen in de geriatrie. LUMC: Boerhaave Commissie PAOG; 2002., p. 1-8
van Gool WA, Use of galantamine to treat vascular dementia. LANCET 2002;360 (9344):1512 [PubMed]
Croes EA, Jansen GH, Lemstra AW, Frijns CJ, van Gool WA, van Duijn CM, The first two patients with dura mater associated Creutzfeldt-Jakob disease in the Netherlands. J NEUROL 2001;248 (10):877-880 [PubMed]
Lemstra AW, van Meegen M, Baas F, van Gool WA, Een klinisch algoritme voor het gebruik van de 14-3-3-liquortest bij de diagnostiek van de ziekte van Creutzfeldt-Jakob. NED TIJDSCHR GENEESKD 2001;145 (30):1467-1471 [PubMed]
Richard E, Lemstra AW, Walstra GJ, van Gool WA, Evaluatie van therapie-effecten bij individuele patiënten met de ziekte van Alzheimer. NED TIJDSCHR GENEESKD 2001;145 (8):340-345 [PubMed]
van Gool WA, Weinstein HC, Scheltens P, Walstra GJ, Scheltens PK, Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: an 18-month randomised, double-blind, placebo-controlled study. LANCET 2001;358 (9280):455-460 [PubMed]
Claus JJ, Ongerboer de Visser BW, Bour LJ, Walstra GJ, Hijdra A, Verbeeten B Jr, van Royen EA, Kwa VI, van Gool WA, Determinants of quantitative spectral electroencephalography in early Alzheimer's disease: cognitive function, regional cerebral blood flow, and computed tomography. DEMENT GERIATR COGN 2000;11 (2):81-89 [PubMed]
Eikelenboom P, Rozemuller AJ, Hoozemans JJ, Veerhuis R, van Gool WA, Neuroinflammation and Alzheimer disease: clinical and therapeutic implications. ALZ DIS ASSOC DIS 2000;14 (Suppl. 1):S54-S61 [PubMed]
Lemstra AW, van Meegen MT, Vreyling JP, Meijerink PH, Jansen GH, Bulk S, Baas F, van Gool WA, 14-3-3 testing in diagnosing Creutzfeldt-Jakob disease: a prospective study in 112 patients. NEUROLOGY 2000;55 (4):514-516 [PubMed]
van Gool WA, Eikelenboom P, The two faces of Alzheimer's disease. J NEUROL 2000;247 (7):500-505 [PubMed]
van Harten B, van Gool WA, van Langen IM, Deekman JM, Meijerink PH, Weinstein HC, A new mutation in the prion protein gene: a patient with dementia and white matter changes. NEUROLOGY 2000;55 (7):1055-1057 [PubMed]
Claus JJ, Strijers RL, Jonkman EJ, Ongerboer de Visser BW, Jonker C, Walstra GJ, Scheltens P, van Gool WA, The diagnostic value of electroencephalography in mild senile Alzheimer's disease. CLIN NEUROPHYSIOL 1999;110 (5):825-832 [PubMed]
Claus JJ, Walstra GJ, Bossuyt PM, Teunisse S, van Gool WA, A simple test of copying ability and sex define survival in patients with early Alzheimer's disease. PSYCHOL MED 1999;29 (2):485-489 [PubMed]
Claus JJ, Walstra GJ, Hijdra A, van Royen EA, Verbeeten B Jr, van Gool WA, Measurement of temporal regional cerebral perfusion with single-photon emission tomography predicts rate of decline in language function and survival in early Alzheimer's disease. EUR J NUCL MED 1999;26 (3):265-271 [PubMed]
van Crevel H, van Gool WA, Walstra GJ, Early diagnosis of dementia: which tests are indicated? What are their costs?. J NEUROL 1999;246 (2):73-78 [PubMed]
van Gool WA, Efficacy of donepezil in Alzheimer's disease: fact or artifact?. NEUROLOGY 1999;52 (1):218-219 [PubMed]
Aerts JMFG, van Gool WA. Inleiding over vouwziekten. in: Borst P, van Everdingen JEE, van Gool WA, editors. Vouwfouten. Prionziekten als model.. Amsterdam-Overveen: Boom-Belvedere; 1998., p. 26-40
Borst P, van Everdingen JEE, van Gool WA, editors, Vouwfouten. Prionziekten als model.. Amsterdam-Overveen: Boom-Belvedere; 1998. 139p.
Claus JJ, Kwa VI, Teunisse S, Walstra GJ, van Gool WA, Koelman JH, Bour LJ, Ongerboer de Visser BW, Slowing on quantitative spectral EEG is a marker for rate of subsequent cognitive and functional decline in early Alzheimer disease. ALZ DIS ASSOC DIS 1998;12 (3):167-174 [PubMed]
Claus JJ, Ongerboer de Visser BW, Walstra GJ, Hijdra A, Verbeeten B Jr, van Gool WA, Quantitative spectral electroencephalography in predicting survival in patients with early Alzheimer disease. ARCH NEUROL-CHICAGO 1998;55 (8):1105-1111 [PubMed]
Claus JJ, Teunisse S, Walstra GJ, van Gool WA, Determinants of global clinical change assessment in patients with early Alzheimer's disease. DEMENT GERIATR COGN 1998;9 (3):157-163 [PubMed]
Claus JJ, van Gool WA, Teunisse S, Walstra GJ, Kwa VI, Hijdra A, Verbeeten B Jr, Koelman JH, Bour LJ, Ongerboer de Visser BW, Predicting survival in patients with early Alzheimer's disease. DEMENT GERIATR COGN 1998;9 (5):284-293 [PubMed]
Scheper W, van Gool WA, Presenilines en de ziekte van Alzheimer. NED TIJDSCHR GENEESKD 1998;142 (22):1247-1252 [PubMed]
Stevens M, van Duijn CM, Kamphorst W, de Knijff P, Heutink P, van Gool WA, Scheltens P, Ravid R, Oostra BA, Niermeijer MF, van Swieten JC, Familial aggregation in frontotemporal dementia. NEUROLOGY 1998;50 (6):1541-1545 [PubMed]
Verhey FR, Heeren TJ, Scheltens P, van Gool WA, Cholinesteraseremmers bij de ziekte van Alzheimer: voorlopige aanbevelingen voor de praktijk. Sectie Psychiatrie voor Ouderen van de Nederlandse Vereniging voor Psychiatrie. NED TIJDSCHR GENEESKD 1998;142 (38):2091-2096 [PubMed]
Walstra GJ, van Gool WA, van Crevel H, Assessment of dementia. LANCET 1998;351 (9115):1585 [PubMed]
Claus JJ, van Gool WA, Feldman H, Mohr E, SPECT in AD. NEUROLOGY 1997;48 (4):1139-1140 [PubMed]
Scheltens P, van Gool WA, Emerging treatments in dementia. EUR NEUROL 1997;38 (3):184-189 [PubMed]
van Gool WA, Meijerink PH, De ziekte van Creutzfeldt-Jakob; een jaar later. NED TIJDSCHR GENEESKD 1997;141 (13):613-615 [PubMed]
van Harten B, van Gool WA, Bienfait HM, Stam J, Brain edema after carotid endarterectomy. NEUROLOGY 1997;48 (2):544-545 [PubMed]
van Harten B, van Gool WA, Legemate DA, Het cerebrale hyperperfusiesyndroom na carotisendarteriëctomie. NED TIJDSCHR GENEESKD 1997;141 (50):2461-2464 [PubMed]
Walstra GJ, Teunisse S, van Gool WA, van Crevel H, Reversible dementia in elderly patients referred to a memory clinic. J NEUROL 1997;244 (1):17-22 [PubMed]
Walstra GJ, Teunisse S, van Gool WA, van Crevel H, Symptomatic treatment of elderly patients with early Alzheimer's disease at a memory clinic. J GERIATR PSYCH NEUR 1997;10 (1):33-38 [PubMed]
Slooter AJ, van Gool WA, van Duijn CM, De plaats van apolipoproteïne-E-genotypering in de differentiaaldiagnostiek van dementie. NED TIJDSCHR GENEESKD 1996;140 (42):2073-2076 [PubMed]
Teunisse S, Bollen AE, van Gool WA, Walstra GJ, Dementia and subnormal levels of vitamin B12: effects of replacement therapy on dementia. J NEUROL 1996;243 (7):522-529 [PubMed]
van der Wurff FB, van Gool WA, Hijdra A, De ziekte van Creutzfeldt-Jakob: diagnostiek bij tien patiënten. NED TIJDSCHR GENEESKD 1996;140 (17):927-931 [PubMed]
van Gool WA, The use of apolipoprotein E genotyping as a diagnostic test in suspected Alzheimer's disease. ANN NY ACAD SCI 1996;802:79-91 [PubMed]
van Gool WA, van Crevel H, Impact on management of new diagnostic tests in Alzheimer's disease. LANCET 1996;348 (9032):961 [PubMed]
van Gool WA, van Crevel H, Nieuwe diagnostische tests voor de ziekte van Alzheimer in de klinische praktijk. NED TIJDSCHR GENEESKD 1996;140 (42):2071-2073 [PubMed]
Wientjens DP, van Gool WA, Portegies P, Jansen GH, Spongiforme encefalopathie bij rund en mens. NED TIJDSCHR GENEESKD 1996;140 (24):1252-1254 [PubMed]
Scheltens P, Launer LJ, Barkhof F, Weinstein HC, van Gool WA, Visual assessment of medial temporal lobe atrophy on magnetic resonance imaging: interobserver reliability. J NEUROL 1995;242 (9):557-560 [PubMed]
van Gool WA, Evenhuis HM, van Duijn CM, A case-control study of apolipoprotein E genotypes in Alzheimer's disease associated with Down's syndrome. Dutch Study Group on Down's Syndrome and Ageing. ANN NEUROL 1995;38 (2):225-230 [PubMed]
van Gool WA, Hensels GW, Hoogerwaard EM, Wiezer JH, Wesseling P, Bolhuis PA, Hypokinesia and presenile dementia in a Dutch family with a novel insertion in the prion protein gene. BRAIN 1995;118 ( Pt 6):1565-1571 [PubMed]
van Gool WA, Hoogerwaard EM, Kuiper MA, Portegies P, Bolhuis PA, Prionziekten: een nieuwe klasse neurodegeneratieve aandoeningen. NED TIJDSCHR GENEESKD 1995;139 (12):606-613 [PubMed]
van Gool WA, Kuiper MA, Walstra GJ, Wolters EC, Bolhuis PA, Concentrations of amyloid beta protein in cerebrospinal fluid of patients with Alzheimer's disease. ANN NEUROL 1995;37 (2):277-279 [PubMed]
van Gool WA, Walstra GJ, Teunisse S, van der Zant FM, Weinstein HC, van Royen EA, Diagnosing Alzheimer's disease in elderly, mildly demented patients: the impact of routine single photon emission computed tomography. J NEUROL 1995;242 (6):401-405 [PubMed]
Walstra GJ, van Gool WA, The need for a "second witness" in diagnosing dementia. J AM GERIATR SOC 1995;43 (10):1176-1177 [PubMed]
Eikelenboom P, Zhan SS, van Gool WA, Allsop D, Inflammatory mechanisms in Alzheimer's disease. TRENDS PHARMACOL SCI 1994;15 (12):447-450 [PubMed]
van Gool WA, Eikelenboom P, Nieuws over de ziekte van Alzheimer. NED TIJDSCHR GENEESKD 1994;138 (3):116-118 [PubMed]
van Gool WA, Hijdra A, Diagnosis of Alzheimer's disease by apolipoprotein E genotyping. LANCET 1994;344 (8917):275 [PubMed]
van Gool WA, Schenk DB, Bolhuis PA, Concentrations of amyloid-beta protein in cerebrospinal fluid increase with age in patients free from neurodegenerative disease. NEUROSCI LETT 1994;172 (1-2):122-124 [PubMed]
Kwa IH, Hijdra A, van Gool WA, Nieuwe diagnostische criteria voor vasculaire dementie; mijlpaal of struikelblok?. NED TIJDSCHR GENEESKD 1993;137 (47):2412-2414 [PubMed]
van Someren EJ, van Gool WA, Vonk BF, Mirmiran M, Speelman JD, Bosch DA, Swaab DF, Ambulatory monitoring of tremor and other movements before and after thalamotomy: a new quantitative technique. J NEUROL SCI 1993;117 (1-2):16-23 [PubMed]
Mirmiran M, Swaab DF, Kok JH, Hofman MA, Witting W, van Gool WA, Circadian rhythms and the suprachiasmatic nucleus in perinatal development, aging and Alzheimer's disease. PROG BRAIN RES 1992;93:151-62; discussion 162-3 [PubMed]
Scheltens P, Weinstein HC, van Gool WA, De waarde van de nieuwe diagnostische technieken bij de ziekte van Alzheimer. NED TIJDSCHR GENEESKD 1992;136 (50):2459-2462 [PubMed]
van Gool WA, Bolhuis PA, Onderzoek naar liquor-diagnostiek bij de ziekte van Alzheimer: een overzicht van de literatuur en van nieuwe ontwikkelingen. TIJDSCHR GERONTOL GERIATR 1992;23 (6):212-216 [PubMed]
Derix MM, Hofstede AB, Teunisse S, Hijdra A, Walstra GJ, Weinstein HC, van Gool WA, CAMDEX-N: de Nederlandse versie van de Cambridge Examination for Mental Disorders of the Elderly met geautomatiseerde dataverwerking. TIJDSCHR GERONTOL GERIATR 1991;22 (4):143-150 [PubMed]
Hijdra A, Derix MM, Teunisse S, van Gool WA, Kwa IH, Dementia after stroke. STROKE 1991;22 (3):416 [PubMed]
van Gool WA, Bolhuis PA, Cerebrospinal fluid markers of Alzheimer's disease. J AM GERIATR SOC 1991;39 (10):1025-1039 [PubMed]
van Gool WA, Waardenburg J, Meyjes FE, Weinstein HC, de Wilde A, The effect of tetrahydroaminoacridine (THA) on P300 in Alzheimer's disease. BIOL PSYCHIAT 1991;30 (9):953-957 [PubMed]
Weinstein HC, Teunisse S, van Gool WA, Tetrahydroaminoacridine and lecithin in the treatment of Alzheimer's disease. Effect on cognition, functioning in daily life, behavioural disturbances and burden experienced by the carers. J NEUROL 1991;238 (1):34-38 [PubMed]
Weinstein HC, Teunisse S, van Gool WA, van Crevel H, Behandeling van de ziekte van Alzheimer met tacrine. NED TIJDSCHR GENEESKD 1991;135 (35):1575-1577 [PubMed]
van Gool WA, Bolhuis PA, Abnormale eiwitten bij de ziekte van Alzheimer. NED TIJDSCHR GENEESKD 1990;134 (10):468-469 [PubMed]
Roozendaal B, van Gool WA, Swaab DF, Hoogendijk JE, Mirmiran M, Changes in vasopressin cells of the rat suprachiasmatic nucleus with aging. BRAIN RES 1987;409 (2):259-264 [PubMed]
van Gool WA, Pronker HF, Mirmiran M, Uylings HB, Effect of housing in an enriched environment on the size of the cerebral cortex in young and old rats. EXP NEUROL 1987;96 (1):225-232 [PubMed]
van Gool WA, Witting W, Mirmiran M, Age-related changes in circadian sleep-wakefulness rhythms in male rats isolated from time cues. BRAIN RES 1987;413 (2):384-387 [PubMed]
Mirmiran M, Brenner E, van Gool WA, Visual and auditory evoked potentials in different areas of rat cerebral cortex. NEUROSCI LETT 1986;72 (3):272-276 [PubMed]
Mirmiran M, van Gool WA, van Haaren F, Polak CE, Environmental influences on brain and behavior in aging and Alzheimer's disease. PROG BRAIN RES 1986;70:443-459 [PubMed]
Swaab DF, Fliers E, van Gool WA, Immunocytochemical localization of vasopressin in the human brain; its possible consequences for therapeutic strategies in aging and dementia. PROG BRAIN RES 1986;65:105-113 [PubMed]
van Gool WA, Mirmiran M, Aging and circadian rhythms. PROG BRAIN RES 1986;70:255-277 [PubMed]
van Gool WA, Mirmiran M, Effects of aging and housing in an enriched environment on sleep-wake patterns in rats. SLEEP 1986;9 (2):335-347 [PubMed]
van Gool WA, Mirmiran M, van Haaren F, Spatial memory and visual evoked potentials in young and old rats after housing in an enriched environment. BEHAV NEURAL BIOL 1985;44 (3):454-469 [PubMed]
van Gool WA, Mirmiran M, Age-related changes in the sleep pattern of male adult rats. BRAIN RES 1983;279 (1-2):394-398 [PubMed]
Key publications

Moll van Charante EP, Richard E, Eurelings LS, van Dalen JW, Ligthart SA, van Bussel EF, Hoevenaar-Blom MP, Vermeulen M, van Gool WA, Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial. LANCET 2016;388 (10046):797-805 [PubMed]
Witlox J, Eurelings LSM, de Jonghe JFM, Kalisvaart KJ, Eikelenboom P, van Gool WA, Delirium in Elderly Patients and the Risk of Postdischarge Mortality, Institutionalization, and Dementia A Meta-analysis. JAMA-J AM MED ASSOC 2010;304 (4):443-451 [PubMed]
van Gool WA, van de Beek D, Eikelenboom P, Systemic infection and delirium: when cytokines and acetylcholine collide. LANCET 2010;375 (9716):773-775 [PubMed]
Ligthart SA, Richard E, Fransen NL, Eurelings LSM, Beem L, Eikelenboom P, van Gool WA, Moll van Charante EP, Association of Vascular Factors With Apathy in Community-Dwelling Elderly Individuals. ARCH GEN PSYCHIAT 2012;69 (6):636-642 [PubMed]
van Gool WA, Weinstein HC, Scheltens P, Walstra GJ, Scheltens PK, Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: an 18-month randomised, double-blind, placebo-controlled study. LANCET 2001;358 (9280):455-460 [PubMed]


All Publications

Research programmes

Changes in cognition, behavior and mood in brain diseases

Diagnosis, therapy and prevention of brain diseases causing dementia or delirium.

Faculty
Prof. dr. W.A. van Gool
Dr. E.P. Moll van Charante PhD

Postdocs
Dr. M.P. Hoevenaar-Blom
Dr. E. Richard

PhD Students
Drs. C. Beishuizen
Drs. J.W. van Dalen
Drs. I.C.M. Hoogland
Drs. H. Thoonsen MD
L.L. van Wanrooij
Drs. D. Westhoff MD
Drs. E.F. van Bussel
Drs. L. Oudewortel

Others
C. Miedema

Other research related activities
  • Voorzitter/President, GR (GezondheidsRaad, Dutch Health Council)
  • Membership of medical or scientific committee, EU (European Union Committee), Scientific Advisory Group Neurology European Medicines Agency
  • Contribution to guidelines and protocols, Chairman Dutch Dementia Guideline Committee
  • (part-time) outside employment, Other
  • Board of directors / Trustees / Supervisory board, ZonMw (Netherlands Organisation for Health Research and Development)
  • Contribution to guidelines and protocols, Delirium
  • Board of directors / Trustees / Supervisory board, Remmert Adriaan Laan Fonds
  • Membership of medical or scientific committee, Hersenstichting, Scientific Advisory Board
  • Board of directors / Trustees / Supervisory board, Spinoza Leerstoel
Current research funding
  • Europese Unie