• Male

Dr. P.I. Bonta MD PhD

Position: Scientific staff member (UD)
Main activities: Patient care, Research
Specialisation: Pulmonology
foto
Focus of research:

Interventional Pulmonology (bronchial thermoplasty)

Pulmonary Hypertension (chronic tromboembolic pulmonary hypertension)

AMC themes: Cardiovascular Diseases, Infection & Immunity
Departments: Pulmonology
Bonta PI, Bogaard HJ, van den Berk I, Niessen HWM, van der Wal A, Symersky P, Pulmonary endarterectomy for calcified amorphous tumour-related pulmonary hypertension. THORAX 2017;72 (6):584-585 [PubMed]
Crombag LMMJ , Szlubowski A, Stigt JA, Schuurbiers O, Korevaar DA, Bonta PI, Annema JT, EUS-B-FNA vs conventional EUS-FNA for left adrenal gland analysis in lung cancer patients. LUNG CANCER 2017;108:38-44 [PubMed]
d'Hooghe JNS, Eberl S, Annema JT, Bonta PI, Propofol and Remifentanil Sedation for Bronchial Thermoplasty: A Prospective Cohort Trial. RESPIRATION 2017;93 (1):58-64 [PubMed]
d'Hooghe JNS, Goorsenberg AWM, de Bruin DM, Roelofs JJTH, Annema JT, Bonta PI, Optical coherence tomography for identification and quantification of human airway wall layers. PLOS ONE 2017;12 (10):e0184145 [PubMed]
d'Hooghe JNS, ten Hacken NH, Weersink EJM, Sterk PJ, Annema JT , Bonta PI, Emerging understanding of the mechanism of action of Bronchial Thermoplasty in asthma. PHARMACOL THERAPEUT 2017;ahead of print [PubMed]
d'Hooghe JNS, van den Berk IAH, Annema JT, Bonta PI, Acute Radiological Abnormalities after Bronchial Thermoplasty: A Prospective Cohort Trial. RESPIRATION 2017;94 (3):258-262 [PubMed]
Wijmans L, d'Hooghe JNS, Bonta PI, Annema JT, Optical coherence tomography and confocal laser endomicroscopy in pulmonary diseases. CURR OPIN PULM MED 2017;23 (3):275-283 [PubMed]
Bonta PI, Crombag L, Annema JT, Linear endobronchial and endoesophageal ultrasound: a practice change in thoracic medicine. CURR OPIN PULM MED 2016;22 (3):281-288 [PubMed]
Li WW, van Boven WJ, Jurhill RR, Bonta PI, Annema JT, de Mol BA, Ectopic pancreas in a giant mediastinal cyst. CLIN RESPIR J 2016;10 (1):125-128 [PubMed]
Manders E, Bonta PI, Kloek JJ, Symersky P, Bogaard HJ, Hooijman PE, Jasper JR, Malik FI, Stienen GJM, Vonk-Noordegraaf A, de Man FS, Ottenheijm CAC, Reduced force of diaphragm muscle fibers in patients with chronic thromboembolic pulmonary hypertension. AM J PHYSIOL-LUNG C 2016;311 (1):L20-L28 [PubMed]
Peters AL, van Hezel ME, Cortjens B, Tuip-de Boer AM, van Bruggen R, de Korte D, Jonkers RE, Bonta PI, Zeerleder SS, Lutter R, Juffermans NP, Vlaar APJ, Transfusion of 35-Day Stored RBCs in the Presence of Endotoxemia Does Not Result in Lung Injury in Humans. CRIT CARE MED 2016;44 (6):e412-e419 [PubMed]
Schuuring MJ, Bonta PI, van Vugt M, Smithuis F, van Delden OM, Annema JT, Stijnis K, Endosonography of a Pulmonary Artery Obstruction in Echinococcosis. RESPIRATION 2016;92 (6):425-427 [PubMed]
van Kan C, van der Plas MN, Reesink HJ, van Steenwijk RP, Kloek JJ, Tepaske R, Bonta PI, Bresser P, Hemodynamic and ventilatory responses during exercise in chronic thromboembolic disease. J THORAC CARDIOV SUR 2016;152 (3):763-771 [PubMed]
Bonta PI, d'Hooghe J, Sterk PJ, Bel EH, Annema JT, Reduction of Airway Smooth Muscle Mass after Bronchial Thermoplasty: Are We There Yet?. AM J RESP CRIT CARE 2015;191 (10):1207-1208 [PubMed]
Bonta PI, Matlung HL, Vos M, Peters SLM, Pannekoek H, Bakker ENTP, de Vries CJM, Nuclear Receptor Nur77 inhibits vascular outward remodeling and reduces macrophage accumulation and matrix metalloproteinase levels. CARDIOVASC RES 2010;87 (3):561-568 [PubMed]
Bonta PI, Pols TWH, van Tiel CM, Vos M, Arkenbout EK, Rohlena J, Koch KT, de Maat MPM, Tanck MWT, de Winter RJ, Pannekoek H, Biessen EAL, Bot I, de Vries CJM, Nuclear Receptor Nurr1 Is Expressed In and Is Associated With Human Restenosis and Inhibits Vascular Lesion Formation In Mice Involving Inhibition of Smooth Muscle Cell Proliferation and Inflammation. CIRCULATION 2010;121 (18):2023-2032 [PubMed]
Pols TWH, Bonta PI, Pires NMM, Otermin I, Vos M, de Vries MR, van Eijk M, Roelofsen J, Havekes LM, Quax PHA, van Kuilenburg ABP, de Waard V, Pannekoek H, de Vries CJM, 6-Mercaptopurine Inhibits Atherosclerosis in Apolipoprotein E*3-Leiden Transgenic Mice Through Atheroprotective Actions on Monocytes and Macrophages. ARTERIOSCL THROM VAS 2010;30 (8):1591-1597 [PubMed]
Bonta PI. NR4A Nuclear receptors in vascular disease. s.l.: s.n.; 2009. 207p. ISBN 9789490122652 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Pannekoek H, de Vries CJM; copromotor(s): )
Roelofs JJTH, Teske GJD, Bonta PI, de Vries CJM, Meijers JCM, Weening JJ, van der Poll T, Florquin S, Plasminogen activator inhibitor-1 regulates neutrophil influx during acute pyelonephritis. KIDNEY INT 2009;75 (1):52-59 [PubMed]
Rohlena J, Volger OL, van Buul JD, Hekking LHP, van Gils JM, Bonta PI, Fontijn RD, Post JA, Hordijk PL, Horrevoets AJG, Endothelial CD81 is a marker of early human atherosclerotic plaques and facilitates monocyte adhesion. CARDIOVASC RES 2009;81 (1):187-196 [PubMed]
van Tiel CM, Bonta PI, Rittersma SZH, Beijk MAM, Bradley EJ, Klous AM, Koch KT, Baas F, Jukema JW, Pons D, Sampietro ML, Pannekoek H, de Winter RJ, de Vries CJM, p27kip1-838C>A Single Nucleotide Polymorphism Is Associated With Restenosis Risk After Coronary Stenting and Modulates p27kip1 Promoter Activity. CIRCULATION 2009;120 (8):669-676 [PubMed]
Bakker ENTP, Matlung HL, Bonta P, de Vries CJ, van Rooijen N, VanBavel E, Blood flow-dependent arterial remodelling is facilitated by inflammation but directed by vascular tone. CARDIOVASC RES 2008;78 (2):341-348 [PubMed]
Bonta PI, de Vries CJM, Hypoxia regulates resistin in vascular smooth muscle cells, what next?. J HYPERTENS 2008;26 (12):2271-2273 [PubMed]
Bonta PI, Vermeulen JN, Speelman P, Prins JM, Severe abacavir hypersensitivity reaction in a patient tested HLA-B*5701 negative. AIDS 2008;22 (12):1522-1523 [PubMed]
Bonta PI, Pols TWH, de Vries CJM, NR4A nuclear receptors in atherosclerosis and vein-graft disease. TRENDS CARDIOVAS MED 2007;17 (3):105-111 [PubMed]
Pires NMM, Pols TWH, de Vries MR, van Tiel CM, Bonta PI, Vos M, Arkenbout EK, Pannekoek H, Jukema JW, Quax PHA, de Vries CJM, Activation of nuclear receptor Nur77 by 6-mercaptopurine protects against neointima formation. CIRCULATION 2007;115 (4):493-500 [PubMed]
Pols TWH, Bonta PI, de Vries CJM, NR4A nuclear orphan receptors: protective in vascular disease?. CURR OPIN LIPIDOL 2007;18 (5):515-520 [PubMed]
Renckens R, Roelofs JJTH, Bonta PI, Florquin S, de Vries CJM, Levi M, Carmeliet P, van't Veer C, van der Poll T, Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia. BLOOD 2007;109 (4):1593-1601 [PubMed]
Bonta PI, van Tiel CM, Vos M, Pols TWH, van Thienen JV, Ferreira V, Arkenbout EK, Seppen J, Spek CA, van der Poll T, Pannekoek H, de Vries CJM, Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses. ARTERIOSCL THROM VAS 2006;26 (10):2288-2294 [PubMed]
Schepers A, Eefting D, Bonta PI, Grimbergen JM, de Vries MR, van Weel V, de Vries CJ, Egashira K, van Bockel JH, Quax PHA, Anti-MCP-1 gene therapy inhibits vascular smooth muscle cells proliferation and attenuates vein graft thickening both in vitro and in vivo. ARTERIOSCL THROM VAS 2006;26 (9):2063-2069 [PubMed]
Bonta PI, Kok MF, Bergman JJGHM, van den Brink GR, Lemkes JS, Tytgat GNJ, Fockens P, Conscious sedation for EUS of the esophagus and stomach: a double-blind, randomized, controlled trial comparing midazolam with placebo. GASTROINTEST ENDOSC 2003;57 (7):842-847 [PubMed]
Key publications

Bonta PI, Pols TWH, van Tiel CM, Vos M, Arkenbout EK, Rohlena J, Koch KT, de Maat MPM, Tanck MWT, de Winter RJ, Pannekoek H, Biessen EAL, Bot I, de Vries CJM, Nuclear Receptor Nurr1 Is Expressed In and Is Associated With Human Restenosis and Inhibits Vascular Lesion Formation In Mice Involving Inhibition of Smooth Muscle Cell Proliferation and Inflammation. CIRCULATION 2010;121 (18):2023-2032 [PubMed]
Bonta PI, d'Hooghe J, Sterk PJ, Bel EH, Annema JT, Reduction of Airway Smooth Muscle Mass after Bronchial Thermoplasty: Are We There Yet?. AM J RESP CRIT CARE 2015;191 (10):1207-1208 [PubMed]


All Publications

Research programmes

Prof. dr. J.T. Annema (Pulmonary Endoscopy)

Other research related activities
  • None reported
Current research funding
  • AMC
  • Holaira, Inc.
  • Longfonds
  • ZonMw