• Principal Investigator
  • Female

Dr. C.M. van der Hoek PhD

Position: Associate professor (UHD)
Main activities: Research
Specialisation: Virology
foto C.M. van der Hoek is one of the AMC Principal Investigators
Focus of research:

There are a variety of diseases for which involvement of a viral pathogen is suspected. Lia van der Hoek has developed a virus-discovery technique that can identify any RNA and DNA virus, in culture or directly in clinical samples (VIDISCA). The method is based on the cDNA amplified restriction fragment length polymorphism technique combined with Next Generation Sequencing and it is successfully used to identify several unknown pathogens among which the human coronavirus HCoV-NL63, Scale Drop Disease Virus and the virus causing Congenital Tremor in piglets. Besides the standard VIDISCA Lia van der Hoek has developed two highly specialized techniques that are able to identify viruses that so far were extremely difficult to recognize: the viruses that share no or very limited identity to known viruses. Via comparisons and antibody capture VIDISCA these viruses are now visible for future research.

Following identification of a virus, a culture system is essential for further investigations. Pseudostratified human airway epithelium is a sophisticated culture system and the best imitation of the human trachea. Lia van der Hoek has used this system to propagate human bocavirus, and human coronavirus-HKU1, two recently identified respiratory viruses for which no culture system was available.

The unbiased identification of viruses allows not only the detection of new viruses but also the description of the entire "virome", which is the pool of viruses present at a certain site of the body (e.g. the gut or the circulation). An example of the virome research of Lia van der Hoek is the investigation of blood of pregnant mothers, of whom it was known whether the offspring did, or did not, develop schizophrenia. This study revealed that a limited virome in the circulation of the pregnant mother is associated with the development of schizophrenia in the offspring.
 

AMC themes: Infection & Immunity
Departments: Medical Microbiology
Berto A, Anh PH, Carrique-Mas JJ, Simmonds P, van Cuong N, Tue NT, van Dung N, Woolhouse ME, Smith I, Marsh GA, Bryant JE, Thwaites GE, Baker S, Rabaa MA [Contributors: Kiet BT, Boni MF, Phu BD, Campbell JI, Hung DM, Huong DT, Oanh DT, Day JN, van Tan D, van Doorn HR, Han DA, Farrar JJ, Trang HTT, Nghia HDT, Long HB, van Duong H, Thu HTK, Cuong LC, Hung M, Phuong T, Phuc T, Phuong T, Luat X, Ha LTT, van Chuong L, Loan MTP, Nadjm B, Bao NT, Tu NC, Thuan ND, Dong N, Chuyen NK, An NN, Vinh NN, Hung NQ, Dung NT, Minh NT, Binh NT, Tham NTH, Tien NTH, Chuc NTK, Le Ngoc NT, Ha NTL, Lien NTN, Diep NTN, Nhung NT, Chau NTS, Chi NTY, Trinh NT, van NT, van Hung N, van Kinh N, van Minh Hoang N, van My N, van Thang N, van Thanh N, van Vinh Chau N, van Xang N, My PH, Khoa PTM, Tam PTT, van Lao P, van Minh P, van Be Bay P, Rahman M, Thompson C, Ngan TTD, Nhu TDH, Chau THM, Toan TK, Phuc TM, Hong TTK, Dung TTN, Thanh TTT, Minh TTT, Nguyen TT, Hien TT, Tri TQ, Hien VB, Tai VN, Cuong VQ, Phat VV, Huong VTL, Hang VtT, Wertheim H, Bogaardt C, Brierley L, Chase-Topping M, Ivens A, Lu L, Rambaut A, Woolhouse M, Cotten M, Oude Munnink BB, Kellam P, Phan MVT, van der Hoek L, Deijs M, Jebbink MF, Farsani SMJ, Saylors K, Wolfe N]] , Detection of potentially novel paramyxovirus and coronavirus viral RNA in bats and rats in the Mekong Delta region of southern Viet Nam. ZOONOSES PUBLIC HLTH 2017;ahead of print [PubMed]
Berto A, Pham HA, Thao TTN, Vy NHT, Caddy SL, Hiraide R, Tue NT, Goodfellow I, Carrique-Mas JJ, Thwaites GE, Baker S, Boni MF [Contributors: Kiet BT, Bryant JE, Phu BD, Campbell JI, Hung DM, Huong DT, Oanh DT, Day JN, van Tan D, van Doorn HR, Han DA, Farrar JJ, Trang HTT, Nghia HDT, Long HB, van Duong H, Thu HTK, Cuong LC, Hung M, Phuong T, Phuc T, Phuong T, Luat X, Ha LTT, van Chuong L, Loan MTP, Nadjm B, Bao NT, Hoa NT, Tu NC, Thuan ND, Dong N, Chuyen NK, An NN, Vinh NN, Hung NQ, Dung NT, Minh NT, Binh NT, Tham NTH, Tien NTH, Chuc NTK, Le Ngoc NT, Ha NTL, Lien NTN, Diep NTN, Nhung NT, Chau NTS, Chi NTY, Trinh NT, van NT, van Cuong N, van Hung N, van Kinh N, van Minh Hoang N, van My N, van Thang N, van Thanh N, van Vinh Chau N, van Xang N, My PH, Khoa PTM, Tam PTT, van Lao P, van Minh P, van Be Bay P, Rabaa MA, Rahman M, Thompson C, Ngan TTD, Nhu TDH, Chau THM, Toan TK, Phuc TM, Hong TTK, Dung TTN, Thanh TTT, Minh TTT, Nguyen TT, Hien TT, Tri TQ, Hien VB, Tai VN, Cuong VQ, Phat VV, Huong VTL, Hang VtT, Wertheim H, Bogaardt C, Chase-Topping M, Ivens A, Lu L, Ngyuen D, Rambaut A, Simmonds P, Woolhouse M, Cotten M, Oude Munnink BB, Kellam P, Phan MVT, van der Hoek L, Deijs M, Jebbink MF, Farsani SMJ, Saylors K, Wolfe N]] , Hepatitis E in southern Vietnam: Seroepidemiology in humans and molecular epidemiology in pigs. ZOONOSES PUBLIC HLTH 2017;ahead of print [PubMed]
Oude Munnink BB, Phan MVT, Simmonds P, Koopmans MPG, Kellam P, van der Hoek L, Cotten M, Characterization of Posa and Posa-like virus genomes in fecal samples from humans, pigs, rats, and bats collected from a single location in Vietnam. VIRUS EVOL 2017;3 (2):vex022 [PubMed]
Agoti CN, Kiyuka PK, Kamau E, Munywoki PK, Bett A, van der Hoek L, Kellam P, Nokes DJ, Cotten M, Human Rhinovirus B and C Genomes from Rural Coastal Kenya. GENOME ANNOUNC 2016;4 (4):e00751-16 [PubMed]
de Groof A, Deijs M, Guelen L, van Grinsven L, van Os-Galdos L, Vogels W, Derks C, Cruijsen T, Geurts V, Vrijenhoek M, Suijskens J, van Doorn P, van Leengoed L, Schrier C, van der Hoek L, Atypical Porcine Pestivirus: A Possible Cause of Congenital Tremor Type A-II in Newborn Piglets. VIRUSES-BASEL 2016;8 (10):271 [PubMed]
Mee ET, Preston MD, Minor PD, Schepelmann S [Contributors: Huang X, Nguyen J, Wall D, Hargrove S, Fu T, Xu G, Li L, Cote C, Delwart E, Li L, Hewlett I, Simonyan V, Ragupathy V, Alin VK, Mermod N, Hill C, Ottenwälder B, Richter DC, Tehrani A, Jacqueline WL, Cassart JP, Letellier C, Vandeputte O, Ruelle JL, Deyati A, La Neve F, Modena C, Mee E, Schepelmann S, Preston M, Minor P, Eloit M, Muth E, Lamamy A, Jagorel F, Cheval J, Anscombe C, Misra R, Wooldridge D, Gharbia S, Rose G, Ng SHS, Charlebois RL, Gisonni-Lex L, Mallet L, Dorange F, Chiu C, Naccache S, Kellam P, van der Hoek L, Cotten M, Mitchell C, Baier BS, Sun W, Malicki HD]] , Development of a candidate reference material for adventitious virus detection in vaccine and biologicals manufacturing by deep sequencing. VACCINE 2016;34 (17):2035-2043 [PubMed]
Oude Munnink BB. The challenges of virus discovery in human fecal samples. S.l.: s.n.; 2016. 159p. ISBN 978-90-9029660-9 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): de Jong MD; copromotor(s): van der Hoek CM)
Oude Munnink BB, Cotten M, Canuti M, Deijs M, Jebbink MF, van Hemert FJ, Phan MVT, Bakker M, Jazaeri Farsani SM, Kellam P, van der Hoek L, A Novel Astrovirus-Like RNA Virus Detected in Human Stool. VIRUS EVOL 2016;2 (1):vew005 [PubMed]
Oude Munnink BB, Phan MVT, van der Hoek L, Kellam P, Cotten M, Genome Sequences of a Novel Vietnamese Bat Bunyavirus. GENOME ANNOUNC 2016;4 (6):e01366-16 [PubMed]
Oude Munnink BB, van der Hoek L, Viruses Causing Gastroenteritis: The Known, The New and Those Beyond. VIRUSES-BASEL 2016;8 (2):UNSP 42 [PubMed]
Phan MVT, Anh PH, Cuong NV, Oude Munnink BB, van der Hoek L, My PT, Tri TN, Bryant JE, Baker S, Thwaites G, Woolhouse M, Kellam P, Rabaa MA, Cotten M, Unbiased whole-genome deep sequencing of human and porcine stool samples reveals circulation of multiple groups of rotaviruses and a putative zoonotic infection. VIRUS EVOL 2016;2 (2):vew027 [PubMed]
Canuti M, Buka S, Jazaeri Farsani SM, Oude Munnink BB, Jebbink MF, van Beveren NJM, de Haan L, Goldstein J, Seidman LJ, Tsuang MT, Storosum JG, van der Hoek L, Reduced maternal levels of common viruses during pregnancy predict offspring psychosis: potential role of enhanced maternal immune activity?. SCHIZOPHR RES 2015;166 (1-3):248-254 [PubMed]
Canuti M, van Beveren NJM, Jazaeri Farsani SM, de Vries M, Deijs M, Jebbink MF, Zaaijer HL, van Schaik BDC, van Kampen AHC, van der Kuyl AC, de Haan L, Storosum JG, van der Hoek L, Viral metagenomics in drug-naïve, first-onset schizophrenia patients with prominent negative symptoms. PSYCHIAT RES 2015;229 (3):678-684 [PubMed]
Corman VM, Baldwin HJ, Tateno AF, Zerbinati RM, Annan A, Owusu M, Nkrumah EE, Maganga GD, Oppong S, Adu-Sarkodie Y, Vallo P, da Silva Filho LVRF, Leroy EM, Thiel V, van der Hoek L, Poon LLM, Tschapka M, Drosten C, Drexler JF, Evidence for an Ancestral Association of Human Coronavirus 229E with Bats. J VIROL 2015;89 (23):11858-11870 [PubMed]
de Groof A, Guelen L, Deijs M, van der Wal Y, Miyata M, Ng KS, van Grinsven L, Simmelink B, Biermann Y, Grisez L, van Lent J, de Ronde A, Chang SF, Schrier C, van der Hoek L, A Novel Virus Causes Scale Drop Disease in Lates calcarifer. PLOS PATHOG 2015;11 (8):e1005074 [PubMed]
Farsani SMJ, Deijs M, Dijkman R, Molenkamp R, Jeeninga RE, Ieven M, Goossens H, van der Hoek L, Culturing of respiratory viruses in well-differentiated pseudostratified human airway epithelium as a tool to detect unknown viruses. INFLUENZA OTHER RESP 2015;9 (1):51-57 [PubMed]
Hofstra JJ, Matamoros S, van de Pol MA, de Wever B, Tanck MW, Wendt-Knol H, Deijs M, van der Hoek L, Wolthers KC, Molenkamp R, Visser CE, Sterk PJ, Lutter R, de Jong MD, Changes in microbiota during experimental human Rhinovirus infection. BMC INFECT DIS 2015;15:336 [PubMed]
Jazaeri Farsani SM, Oude Munnink BB, Canuti M, Deijs M, Cotten M, Jebbink MF, Verhoeven J, Kellam P, Loens K, Goossens H, Ieven M, van der Hoek L, Identification of a novel human rhinovirus C type by antibody capture VIDISCA-454. VIRUSES-BASEL 2015;7 (1):239-251 [PubMed]
Oude Munnink BB, Cotten M, Deijs M, Jebbink MF, Bakker M, Farsani SMJ, Canuti M, Kellam P, van der Hoek L, A novel genus in the order Picornavirales detected in human stool. J GEN VIROL 2015;96 (11):3440-3443 [PubMed]
Rabaa MA, Tue NT, Phuc TM, Carrique-Mas J, Saylors K, Cotten M, Bryant JE, Nghia HDT, Cuong NV, Pham HA, Berto A, Phat VV, Dung TTN, Bao LH, Hoa NT, Wertheim H, Nadjm B, Monagin C, van Doorn HR, Rahman M, Tra MPV, Campbell JI, Boni MF, Tam PTT, van der Hoek L, Simmonds P, Rambaut A, Toan TK, van Vinh Chau N, Hien TT, Wolfe N, Farrar JJ, Thwaites G, Kellam P, Woolhouse MEJ, Baker S, The Vietnam Initiative on Zoonotic Infections (VIZIONS): A Strategic Approach to Studying Emerging Zoonotic Infectious Diseases. ECOHEALTH 2015;12 (4):726-735 [PubMed]
Canuti M, Deijs M, Jazaeri Farsani SM, Holwerda M, Jebbink MF, de Vries M, van Vugt S, Brugman C, Verheij T, Lammens C, Goossens H, Loens K, Ieven M, van der Hoek L, Metagenomic analysis of a sample from a patient with respiratory tract infection reveals the presence of a gamma-papillomavirus. FRONT MICROBIOL 2014;5:347 [PubMed]
Canuti M, van der Hoek L, Virus discovery: are we scientists or genome collectors?. TRENDS MICROBIOL 2014;22 (5):229-231 [PubMed]
Canuti M, Williams CV, Gadi SR, Jebbink MF, Oude Munnink BB, Jazaeri Farsani SM, Cullen JM, van der Hoek L, Persistent viremia by a novel parvovirus in a slow loris (Nycticebus coucang) with diffuse histiocytic sarcoma. FRONT MICROBIOL 2014;5:655 [PubMed]
Cotten M, Oude Munnink B, Canuti M, Deijs M, Watson SJ, Kellam P, van der Hoek L, Full genome virus detection in fecal samples using sensitive nucleic acid preparation, deep sequencing, and a novel iterative sequence classification algorithm. PLOS ONE 2014;9 (4):e93269 [PubMed]
Jazaeri Farsani SM. Respiratory viruses and novel methods for virus discovery. S.l.: s.n.; 2014. 133p. ISBN 9789461824943 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Berkhout B; copromotor(s): van der Hoek CM)
Le VT, de Jong MD, Nguyen VK, Nguyen VT, Taylor W, Wertheim HFL, van der Ende A, van der Hoek L, Canuti M, Crusat M, Sona S, Nguyen HU, Giri A, Nguyen TTCB, Ho DTN, Farrar J, Bryant JE, Tran TH, Nguyen VVC, van Doorn HR, Limited geographic distribution of the novel cyclovirus CyCV-VN. SCI REP-UK 2014;4:3967 [PubMed]
Oude Munnink BB, Canuti M, Deijs M, de Vries M, Jebbink MF, Rebers S, Molenkamp R, van Hemert FJ, Chung K, Cotten M, Snijders F, Sol CJA, van der Hoek L, Unexplained diarrhoea in HIV-1 infected individuals. BMC INFECT DIS 2014;14 (1):22 [PubMed]
Pariani E, Martinelli M, Canuti M, Jazaeri Farsani SM, Oude Munnink BB, Deijs M, Tanzi E, Zanetti A, van der Hoek L, Amendola A, Influenza and other respiratory viruses involved in severe acute respiratory disease in northern Italy during the pandemic and postpandemic period (2009-2011). BIOMED RES INT 2014;2014:241298 [PubMed]
Shaukat S, Angez M, Alam MM, Jebbink MF, Deijs M, Canuti M, Sharif S, de Vries M, Khurshid A, Mahmood T, van der Hoek L, Zaidi SSZ, Identification and characterization of unrecognized viruses in stool samples of non-polio acute flaccid paralysis children by simplified VIDISCA. VIROL J 2014;11 (1):146 [PubMed]
de Vries M. Virus discovery and human parechoviruses. s.l.: s.n.; 2013. 137p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Berkhout B; copromotor(s): van der Hoek CM)
Dijkman R, Jebbink MF, Koekkoek SM, Deijs M, Jónsdóttir HR, Molenkamp R, Ieven M, Goossens H, Thiel V, van der Hoek L, Isolation and characterization of current human coronavirus strains in primary human epithelial cell cultures reveal differences in target cell tropism. J VIROL 2013;87 (11):6081-6090 [PubMed]
Jazaeri Farsani SM, Jebbink MF, Deijs M, Canuti M, van Dort KA, Bakker M, Grady BPX, Prins M, van Hemert FJ, Kootstra NA, van der Hoek L, Identification of a new genotype of Torque Teno Mini virus. VIROL J 2013;10 (1):323 [PubMed]
Oude Munnink BB, Jazaeri Farsani SM, Deijs M, Jonkers J, Verhoeven JTP, Ieven M, Goossens H, de Jong MD, Berkhout B, Loens K, Kellam P, Bakker M, Canuti M, Cotten M, van der Hoek L, Autologous antibody capture to enrich immunogenic viruses for viral discovery. PLOS ONE 2013;8 (11):e78454 [PubMed]
Reusken C, Mou H, Godeke GJ, van der Hoek L, Meyer B, Müller MA, Haagmans B, de Sousa R, Schuurman N, Dittmer U, Rottier P, Osterhaus A, Drosten C, Bosch BJ, Koopmans M, Specific serology for emerging human coronaviruses by protein microarray. EUROSURVEILLANCE 2013;18 (14):20441-8 [PubMed]
Tan LV, van Doorn HR, Nghia HDT, Chau TTH, Tu LTP, de Vries M, Canuti M, Deijs M, Jebbink MF, Baker S, Bryant JE, Tham NT, Bkrong NTTC, Boni MF, Loi TQ, Phuong LT, Verhoeven JTP, Crusat M, Jeeninga RE, Schultsz C, Chau NVV, Hien TT, van der Hoek L, Farrar J, de Jong MD, Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections. MBIO 2013;4 (3):e00231-e00213 [PubMed]
de Vries M, Oude Munnink BB, Deijs M, Canuti M, Koekkoek SM, Molenkamp R, Bakker M, Jurriaans S, van Schaik BDC, Luyf AC, Olabarriaga SD, van Kampen AHC, van der Hoek L, Performance of VIDISCA-454 in Feces-Suspensions and Serum. VIRUSES-BASEL 2012;4 (8):1328-1334 [PubMed]
Dijkman R, Jebbink MF, Deijs M, Milewska A, Pyrc K, Buelow E, van der Bijl A, van der Hoek L, Replication-dependent downregulation of cellular angiotensin-converting enzyme 2 protein expression by human coronavirus NL63. J GEN VIROL 2012;93 (9):1924-1929 [PubMed]
Dijkman R, Jebbink MF, Gaunt E, Rossen JWA, Templeton KE, Kuijpers TW, van der Hoek L, The dominance of human coronavirus OC43 and NL63 infections in infants. J CLIN VIROL 2012;53 (2):135-139 [PubMed]
Farsani SMJ, Dijkman R, Jebbink MF, Goossens H, Ieven M, Deijs M, Molenkamp R, van der Hoek L, The first complete genome sequences of clinical isolates of human coronavirus 229E. VIRUS GENES 2012;45 (3):433-439 [PubMed]
Kawase M, Shirato K, van der Hoek L, Taguchi F, Matsuyama S, Simultaneous Treatment of Human Bronchial Epithelial Cells with Serine and Cysteine Protease Inhibitors Prevents Severe Acute Respiratory Syndrome Coronavirus Entry. J VIROL 2012;86 (12):6537-6545 [PubMed]
van der Heijden M, de Vries M, van Steenbeek FG, Favier RP, Deijs M, Brinkhof B, Rothuizen J, van der Hoek L, Penning LC, Sequence-independent VIDISCA-454 technique to discover new viruses in canine livers. J VIROL METHODS 2012;185 (1):152-155 [PubMed]
Canuti M, Eis-Huebinger AM, Deijs M, de Vries M, Drexler JF, Oppong SK, Müller MA, Klose SM, Wellinghausen N, Cottontail VM, Kalko EKV, Drosten C, van der Hoek L, Two novel parvoviruses in frugivorous New and Old World bats. PLOS ONE 2011;6 (12):e29140 [PubMed]
de Vries M, Deijs M, Canuti M, van Schaik BDC, Faria NR, van de Garde MDB, Jachimowski LCM, Jebbink MF, Jakobs M, Luyf ACM, Coenjaerts FEJ, Claas ECJ, Molenkamp R, Koekkoek SM, Lammens C, Leus F, Goossens H, Ieven M, Baas F, van der Hoek L, A Sensitive Assay for Virus Discovery in Respiratory Clinical Samples. PLOS ONE 2011;6 (1):e16118 [PubMed]
Dijkman R. Characterization of novel human respiratory viruses. s.l.: s.n.; 2011. 210p. ISBN 9789053354469 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Berkhout B; copromotor(s): van der Hoek CM)
Sastre P, Dijkman R, Camuñas A, Ruiz T, Jebbink MF, van der Hoek L, Vela C, Rueda P, Differentiation between Human Coronaviruses NL63 and 229E Using a Novel Double-Antibody Sandwich Enzyme-Linked Immunosorbent Assay Based on Specific Monoclonal Antibodies. CLIN VACCINE IMMUNOL 2011;18 (1):113-118 [PubMed]
Tan LV, van Doorn HR, van der Hoek L, Minh Hien V, F Jebbink M, Quang Ha D, Farrar J, van Vinh Chau N, de Jong MD, Random PCR and ultracentrifugation increases sensitivity and throughput of VIDISCA for screening of pathogens in clinical specimens. J INFECT DEV COUNTR 2011;5 (2):142-148 [PubMed]
Benschop KSM, de Vries M, Minnaar RP, Stanway G, van der Hoek L, Wolthers KC, Simmonds P, Comprehensive full-length sequence analyses of human parechoviruses: diversity and recombination. J GEN VIROL 2010;91 (Part 1):145-154 [PubMed]
Bezemer D, van Sighem A, Lukashov VV, van der Hoek L, Back N, Schuurman R, Boucher CAB, Claas ECJ, Boerlijst MC, Coutinho RA, de Wolf F [Contributors: Prins JM, Bos JC, Eeftinck-Schattenkerk JKM, Geerlings SE, Godfried MH, Lange JMA, van der Meer JTM, Nellen FJB, Olszyna DP, van der Poll T, Reiss P, Sankatsing SUC, Steingrover R, van der Valk M, Vermeulen JN, Vrouenraets SME, van Vugt M, Schrei G, van der Geest S, Oude Lashof A, Lowe S, Verbon A, Bravenboer B, Pronk MJH, Kuijpers TW, Pajkrt D, Scherpbier HJ, van der Ende ME, Bax H, van der Feltz M, Gelinck LBS, de Melo M, Nouwen JL, Rijnders BJA, de Ruiter ED, Slobbe L, Schurink CAM, de Vries TEMS, Driessen G, van der Flier M, Hartwig NG, Branger J, Kauffmann RH, Pogany K, Schippers EF, Groeneveld PHP, Alleman MA, ten Kate RW, Soetekouw R, Kroon FP, Arend SM, de Boer MGJ, van den Broek PJ, van Dissel JT, van Nieuwkoop C, den Hollander JG, Bronsveld W, Vriesendorp R, Jeurissen FJF, Leyten EMS, van Houte D, Polee MB, ten Napel CHH, Kootstra GJ, Brinkman K, van den Berk GEL, Blok WL, Frissen PHJ, Schouten WEM, van Eeden A, Verhagen DWM, Mulde JW, van Gorp ECM, Mairuhu ATA, Wagenaar J, Juttmann JR, van Kasteren MEE, Veenstra J, Vasmel WLE, Koopmans PP, Brouwer AM, Dofferhoff ASM, de Groot R, ter Hofstede HJM, Keuter M, van der Ven AJAM, Sprenger HG, van Assen S, van Leeuwen JTM, Stek CJ, Doedens R, Scholvinck EH, Hoepelman IM, Schneider MME, Bonten MJM, Ellerbroek PM, Jaspers CAJJ, Maarschalk-Ellerbroek LJ, Oosterheert JJ, Peters EJG, Mudrikova T, Wassenberg MWM, Weijer S, Geelen SPM, Wolfs TFW, Danner SA, van Agtmael MA, Bierman WFW, Claessen FAP, Hillebrand ME, de Jong EV, Kortmann W, Perenboom RM, bij de Vaate EA, Richter C, van der Berg J, Gisolf EH, Tanis AA, Duits AJ, Winkel K, Back NKT, Bakker MEG, Zaaijer HL, Berkhout B, Jurriaans S, Cuijpers T, Rietra PJGM, Roozendaal KJ, Pauw W, Smits PHM, van Zanten AP, von Blomberg BME, Pettersson A, Savelkoul P, Swanink CMA, Franck PFH, Lampe AS, Jansen CL, Hendriks R, Benne CA, Schirm J, Veenendaal D, Storm H, Weel J, van Zeijl JH, Claas HCJ, Kroes ACM, Bruggeman CAMVA, Goossens VJ, Galama JMD, Melchers WJG, Lunel V, van Doornum GJJ, Niesters HGM, Osterhaus ADME, Schutten M, Buiting AGM, Boucher CAB, Boel E, Schuurman R, Jansz AF, Wulf M, Veldkamp A, Beijnen JH, Huitema ADR, Burger DM, van Kan HJM]] , Transmission networks of HIV-1 among men having sex with men in the Netherlands. AIDS 2010;24 (2):271-282 [PubMed]
Müller MA, van der Hoek L, Voss D, Bader O, Lehmann D, Schulz AR, Kallies S, Suliman T, Fielding BC, Drosten C, Niedrig M, Human Coronavirus NL63 Open Reading Frame 3 encodes a virion-incorporated N-glycosylated membrane protein. VIROL J 2010;7 (1):6 [PubMed]
Pyrc K, Sims AC, Dijkman R, Jebbink M, Long C, Deming D, Donaldson E, Vabret A, Baric R, van der Hoek L, Pickles R, Culturing the Unculturable: Human Coronavirus HKU1 Infects, Replicates, and Produces Progeny Virions in Human Ciliated Airway Epithelial Cell Cultures. J VIROL 2010;84 (81):11255-11263 [PubMed]
van der Hoek L, Ihorst G, Sure K, Vabret A, Dijkman R, de Vries M, Forster J, Berkhout B, Uberla K, Burden of disease due to human coronavirus NL63 infections and periodicity of infection. J CLIN VIROL 2010;48 (2):104-108 [PubMed]
Wevers BA, van der Hoek L, Renin-angiotensin system in human coronavirus pathogenesis. FUTURE VIROL 2010;5 (2):145-161
Dijkman R, Koekkoek SM, Molenkamp R, Schildgen O, van der Hoek L, Human Bocavirus Can Be Cultured in Differentiated Human Airway Epithelial Cells. J VIROL 2009;83 (15):7739-7748 [PubMed]
Dijkman R, Mulder HL, Rumping L, Kraaijvanger I, Deijs M, Jebbink MF, Verschoor EJ, van der Hoek L, Seroconversion to HCoV-NL63 in Rhesus Macaques. VIRUSES-BASEL 2009;1 (3):647-656 [PubMed]
Dijkman R, van der Hoek L, Human Coronaviruses 229E and NL63: Close Yet Still So Far. J FORMOS MED ASSOC 2009;108 (4):270-279 [PubMed]
Faria NR, de Vries M, van Hemert FJ, Benschop K, van der Hoek L, Rooting human parechovirus evolution in time. BMC EVOL BIOL 2009;9 (1):164 [PubMed]
Wevers BA, van der Hoek L, Recently Discovered Human Coronaviruses. CLIN LAB MED 2009;29 (4):715-+ [PubMed]
Bezemer D, van Sighem A, de Wolf F, Cornelissen M, van der Kuyl AC, Jurriaans S, van der Hoek L, Prins M, Coutinho RA, Lukashov VV, Combination antiretroviral therapy failure and HIV super-infection. AIDS 2008;22 (2):309-311 [PubMed]
de Vries M, Pyrc K, Berkhout R, Vermeulen-Oost W, Dijkman R, Jebbink MF, Bruisten S, Berkhout B, van der Hoek L, Human parechovirus type 1, 3, 4, 5, and 6 detection in picornavirus cultures. J CLIN MICROBIOL 2008;46 (2):759-762 [PubMed]
Dijkman R, Jebbink MF, Bahia El Idrissi N, Pyrc K, Mueller MA, Kuijpers TW, Zaaijer HL, van der Hoek L, Human coronavirus NL63 and 229E seroconversion in children. J CLIN MICROBIOL 2008;46 (7):2368-2373 [PubMed]
Mathewson AC, Bishop A, Yao Y, Kemp F, Ren J, Chen H, Xu X, Berkhout B, van der Hoek L, Jones IM, Interaction of severe acute respiratory syndrome-coronavirus and NL63 coronavirus spike proteins with angiotensin converting enzyme-2. J GEN VIROL 2008;89 (Part 11):2741-2745 [PubMed]
Pyrc K, Jebbink MF, Berkhout B, van der Hoek L, Detection of New Viruses by VIDISCA : Virus Discovery Based on cDNA-Amplified Fragment Length Polymorphism. METHODS MOL BIOL 2008;454:1-17 [PubMed]
Tan LV, Ha DQ, Hien VM, van der Hoek L, Farrar J, de Jong MD, Me Tri virus: a Semliki Forest virus strain from Vietnam?. J GEN VIROL 2008;89 (Part 9):2132-2135 [PubMed]
Wu PS, Chang LY, Berkhout B, van der Hoek L, Lu CY, Kao CL, Lee PI, Shao PL, Lee CY, Huang FY, Huang LM, Clinical manifestations of human coronavirus NL63 infection in children in Taiwan. EUR J PEDIATR 2008;167 (1):75-80 [PubMed]
Pyrc KA. Virus discovery and human coronavirus NL63. s.l.: s.n.; 2007. 278p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Berkhout B; copromotor(s): van der Hoek CM)
Pyrc K, Berkhout B, van der Hoek L, Antiviral strategies against human coronaviruses. INFECT DISORD DRUG TARGETS 2007;7 (1):59-66 [PubMed]
Pyrc K, Berkhout B, van der Hoek L, Identification of new human coronaviruses. EXPERT REV ANTI-INFE 2007;5 (2):245-253 [PubMed]
Pyrc K, Berkhout B, van der Hoek L, The novel human coronaviruses NL63 and HKU1. J VIROL 2007;81 (7):3051-3057 [PubMed]
van der Hoek L, Human coronaviruses: what do they cause?. ANTIVIR THER 2007;12 (4 Part B):651-658 [PubMed]
van der Hoek L, Pollakis G, Lukashov VV, Jebbink MF, Jeeninga RE, Bakker M, Dukers N, Jurriaans S, Paxton WA, Back NKT, Berkhout B, Characterization of an HIV-1 group M variant that is distinct from the known subtypes. AIDS RES HUM RETROV 2007;23 (3):466-470 [PubMed]
Baker SC, Shimizu C, Shike H, Garcia F, van der Hoek L, Kuijper TW, Reed SL, Rowley AH, Shulman ST, Talbot HKB, Williams JV, Burns JC, Human coronavirus-NL63 infection is not associated with acute Kawasaki disease. ADV EXP MED BIOL 2006;581:523-526 [PubMed]
Berkhout B, Back NK, de Ronde A, Jurriaans S, Bakker M, Parkin NT, van der Hoek L, Identification of alternative amino acid substitutions in drug-resistant variants of the HIV-1 reverse transcriptase. AIDS 2006;20 (11):1515-1520 [PubMed]
Bezemer D, de Ronde A, Prins M, Porter K, Gifford R, Pillay D, Masquelier B, Fleury H, Dabis F, Back N, Jurriaans S, van der Hoek L, Evolution of transmitted HIV-1 with drug-resistance mutations in the absence of therapy: effects on CD4+ T-cell count and HIV-1 RNA load. ANTIVIR THER 2006;11 (2):173-178 [PubMed]
Dijkman R, Jebbink MF, Wilbrink B, Pyrc K, Zaaijer HL, Minor PD, Franklin S, Berkhout B, Thiel V, van der Hoek L, Human coronavirus 229E encodes a single ORF4 protein between the spike and the envelope genes. VIROL J 2006;3:106 [PubMed]
Hofman H, Marzi A, Gramberg T, Geier M, Pyrc K, van der Hoek L, Berkhout B, Pöhlmann S. Attachment factor and receptor engagement of SARS coronavirus and human coronavirus NL63 in: Perlman S, Holmes KV, editors. The Nidoviruses: toward control of SARS and other nidovirus diseases. S.l.: Springer; 2006., p. 219-227
Hofmann H, Marzi A, Gramberg T, Geier M, Pyrc K, van der Hoek L, Berkhout B, Pöhlmann S, Attachment factor and receptor engagement of SARS coronavirus and human coronavirus NL63. ADV EXP MED BIOL 2006;581:219-227 [PubMed]
Koetz A, Nilsson P, Lindén M, van der Hoek L, Ripa T, Detection of human coronavirus NL63, human metapneumovirus and respiratory syncytial virus in children with respiratory tract infections in south-west Sweden. CLIN MICROBIOL INFEC 2006;12 (11):1089-1096 [PubMed]
Piotrowski Y, van der Hoek L, Pyrc K, Berkhout B, Moll R, Hilgenfeld R, Nonstructural proteins of human coronavirus NL63. ADV EXP MED BIOL 2006;581:97-100 [PubMed]
Piotrowski Y, van der Hoek L, Pyrc K, Berkhout B, Moll R, Hilgenfeld R. Nonstructural proteins of human coronavirus NL63 in: Perlman S, Holmes KV, editors. The Nidoviruses: toward control of SARS and other nidovirus diseases. S.l.: Springer; 2006., p. 97-100
Pöhlmann S, Gramberg T, Wegele A, Pyrc K, van der Hoek L, Berkhout B, Hofman H. Interaction between the spike protein of human coronavirus NL63 and its cellular receptor ACE2 in: Perlman S, Holmes KV, editors. The Nidoviruses: toward control of SARS and other nidovirus diseases. S.l.: Springer; 2006., p. 281-284
Pöhlmann S, Gramberg T, Wegele A, Pyrc K, van der Hoek L, Berkhout B, Hofmann H, Interaction between the spike protein of human coronavirus NL63 and its cellular receptor ACE2. ADV EXP MED BIOL 2006;581:281-284 [PubMed]
Pyrc K, Bosch BJ, Berkhout B, Jebbink MF, Dijkman R, Rottier P, van der Hoek L, Inhibition of human coronavirus NL63 infection at early stages of the replication cycle. ANTIMICROB AGENTS CH 2006;50 (6):2000-2008 [PubMed]
Pyrc K, Dijkman R, Deng L, Jebbink MF, Ross HA, Berkhout B, van der Hoek L, Mosaic structure of human coronavirus NL63, one thousand years of evolution. J MOL BIOL 2006;364 (5):964-973 [PubMed]
Schildgen O, Jebbink MF, de Vries M, Pyrc K, Dijkman R, Simon A, Müller A, Kupfer B, van der Hoek L, Identification of cell lines permissive for human coronavirus NL63. J VIROL METHODS 2006;138 (1-2):207-210 [PubMed]
Smith MK, Tusell S, Travanty EA, Berkhout B, van der Hoek L, Holmes KV, Human angiotensin-converting enzyme 2 (ACE2) is a receptor for human respiratory coronavirus NL63. ADV EXP MED BIOL 2006;581:285-288 [PubMed]
Smith MK, Tusell S, Travanty EA, Berkhout B, van der Hoek L, Holmes KV. Human angiotensin-converting enzyme 2 (ACE2) is a receptor for human respiratory coronavirus NL63 in: Perlman S, Holmes KV, editors. The Nidoviruses: toward control of SARS and other nidovirus diseases. S.l.: Springer; 2006., p. 285-288
van der Hoek CM, Pyrc K, Berkhout B, Coronavirus NL63, de Hollandse nieuwe. TIJDSCHR INFECTIEZIEKTEN 2006;1 (3):108-ev
van der Hoek L, Pyrc K, Berkhout B, Human coronavirus NL63, a new respiratory virus. FEMS MICROBIOL REV 2006;30 (5):760-773 [PubMed]
van der Hoek L, Sure K, Ihorst G, Stang A, Pyrc K, Jebbink MF, Petersen G, Forster J, Berkhout B, Uberla K, Human coronavirus NL63 infection is associated with croup. ADV EXP MED BIOL 2006;581:485-491 [PubMed]
van der Hoek L, Sure K, Ihorst G, Stang A, Pyrc K, Jebbink MF, Petersen G, Forster J, Berkhout B, Überla K. Human coronavirus NL63 infection is associated with group in: Perlman S, Holmes KV, editors. The Nidoviruses: toward control of SARS and other nidovirus diseases. S.l.: Springer; 2006., p. 485-491
Zheng Q, Deng Y, Liu J, van der Hoek L, Berkhout B, Lu M, Core structure of S2 from the human coronavirus NL63 spike glycoprotein. BIOCHEMISTRY-US 2006;45 (51):15205-15215 [PubMed]
Berkhout B, de Ronde A, van der Hoek L, Aggressive HIV-1?. RETROVIROLOGY 2005;2 (1):13 [PubMed]
Hofmann H, Pyrc K, van der Hoek L, Geier M, Berkhout B, Pöhlmann S, Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry. P NATL ACAD SCI USA 2005;102 (22):7988-7993 [PubMed]
Masquelier B, Bhaskaran K, Pillay D, Gifford R, Balestre E, Jørgensen LB, Pedersen C, van der Hoek L, Prins M, Balotta C, Longo B, Kücherer C, Poggensee G, Ortiz M, de Mendoza C, Gill J, Fleury H, Porter K, Prevalence of transmitted HIV-1 drug resistance and the role of resistance algorithms - Data from seroconverters in the CASCADE collaboration from 1987 to 2003. JAIDS-J ACQ IMM DEF 2005;40 (5):505-511 [PubMed]
Moës E, Vijgen L, Keyaerts E, Zlateva K, Li S, Maes P, Pyrc K, Berkhout B, van der Hoek L, van Ranst M, A novel pancoronavirus RT-PCR assay: frequent detection of human coronavirus NL63 in children hospitalized with respiratory tract infections in Belgium. BMC INFECT DIS 2005;5 (1):6 [PubMed]
Pyrc K, Berkhout B, van der Hoek L. Molecular characterization of human coronavirus NL63 in: Recent Res Devel Infection & Immunity. Kerala. India: Transworld Research Network; 2005.
Shimizu C, Shike H, Baker SC, Garcia F, van der Hoek L, Kuijpers TW, Reed SL, Rowley AH, Shulman ST, Talbot HKB, Williams JV, Burns JC, Human coronavirus NL63 is not detected in the respiratory tracts of children with acute Kawasaki disease. J INFECT DIS 2005;192 (10):1767-1771 [PubMed]
Vabret A, Mourez T, Dina J, van der Hoek L, Gouarin S, Petitjean J, Brouard J, Freymuth F, Human coronavirus NL63, France. EMERG INFECT DIS 2005;11 (8):1225-1229 [PubMed]
van der Hoek L, Back N, Jebbink MF, de Ronde A, Bakker M, Jurriaans S, Reiss P, Parkin N, Berkhout B, Increased multinucleoside drug resistance and decreased replicative capacity of a human immunodeficiency virus type 1 variant with an 8-amino-acid insert in the reverse transcriptase. J VIROL 2005;79 (6):3536-3543 [PubMed]
van der Hoek L, Berkhout B, Questions concerning the new haven coronavirus. J INFECT DIS 2005;192 (2):350-351 [PubMed]
van der Hoek L, Sure K, Ihorst G, Stang A, Pyrc K, Jebbink MF, Petersen G, Forster J, Berkhout B, Uberla K, Croup is associated with the novel coronavirus NL63. PLOS MED 2005;2 (8):764 e240-770 [PubMed]
Bezemer D, Jurriaans S, Prins M, van der Hoek L, Prins JM, de Wolf F, Berkhout B, Coutinho R, Back NKT, Declining trend in transmission of drug-resistant HIV-1 in Amsterdam. AIDS 2004;18 (11):1571-1577 [PubMed]
Pyrc K, Jebbink MF, Berkhout B, van der Hoek L, Genome structure and transcriptional regulation of human coronavirus NL63. VIROL J 2004;1 (1):7 [PubMed]
van der Hoek L, Pyrc K, Jebbink MF, Vermeulen-Oost W, Berkhout RJM, Wolthers KC, Wertheim-van Dillen PME, Kaandorp J, Spaargaren J, Berkhout B, Identification of a new human coronavirus. NAT MED 2004;10 (4):368-373 [PubMed]
Geels MJ, Cornelissen M, Schuitemaker H, Anderson K, Kwa D, Maas J, Dekker JT, Baan E, Zorgdrager F, van den Burg R, van Beelen M, Lukashov VV, Fu TM, Paxton WA, van der Hoek L, Dubey SA, Shiver JW, Goudsmit J, Identification of sequential viral escape mutants associated with altered T-cell responses in a human immunodeficiency virus type 1-infected individual. J VIROL 2003;77 (23):12430-12440 [PubMed]
de Ronde A, van Dooren M, van der Hoek L, Bouwhuis D, de Rooij E, van Gemen B, de Boer R, Goudsmit J, Establishment of new transmissible and drug-sensitive human immunodeficiency virus type 1 wild types due to transmission of nucleoside analogue-resistant virus. J VIROL 2001;75 (2):595-602 [PubMed]
Goudsmit J, Weverling GJ, van der Hoek L, de Ronde A, Miedema F, Coutinho RA, Lange JM, Boerlijst MC, Carrier rate of zidovudine-resistant HIV-1: the impact of failing therapy on transmission of resistant strains. AIDS 2001;15 (17):2293-2301 [PubMed]
Putter H, Prins JM, Jurriaans S, Roos M, Ferguson NM, van Praag R, van der Hoek L, Schuitemaker H, Anderson RM, Goudsmit J, Lange JM, de Wolf F, Slower decline of plasma HIV-1 RNA following highly suppressive antiretroviral therapy in primary compared with chronic infection. AIDS 2000;14 (18):2831-2839 [PubMed]
van der Hoek L, Goudsmit J, Maas J, Sol CJ, Human immunodeficiency virus type 1 in faeces and serum: evidence against independently evolving subpopulations. J GEN VIROL 1998;79 ( Pt 10):2455-2459 [PubMed]
van der Hoek L, Sol CJ, Maas J, Lukashov VV, Kuiken CL, Goudsmit J, Genetic differences between human immunodeficiency virus type 1 subpopulations in faeces and serum. J GEN VIROL 1998;79 ( Pt 2):259-267 [PubMed]
Snijders F, Kuijper EJ, de Wever B, van der Hoek L, Danner SA, Dankert J, Prevalence of Campylobacter-associated diarrhea among patients infected with human immunodeficiency virus. CLIN INFECT DIS 1997;24 (6):1107-1113 [PubMed]
van der Hoek L, Sol CJ, Snijders F, Bartelsman JF, Boom R, Goudsmit J, Human immunodeficiency virus type 1 RNA populations in faeces with higher homology to intestinal populations than to blood populations. J GEN VIROL 1996;77 ( Pt 10):2415-2425 [PubMed]
Cornelissen M, Mulder-Kampinga G, Veenstra J, Zorgdrager F, Kuiken C, Hartman S, Dekker J, van der Hoek L, Sol C, Coutinho R, Syncytium-inducing (SI) phenotype suppression at seroconversion after intramuscular inoculation of a non-syncytium-inducing/SI phenotypically mixed human immunodeficiency virus population. J VIROL 1995;69 (3):1810-1818 [PubMed]
van der Hoek L, Boom R, Goudsmit J, Snijders F, Sol CJ, Isolation of human immunodeficiency virus type 1 (HIV-1) RNA from feces by a simple method and difference between HIV-1 subpopulations in feces and serum. J CLIN MICROBIOL 1995;33 (3):581-588 [PubMed]
Zwart G, Back NK, Ramautarsing C, Valk M, van der Hoek L, Goudsmit J, Frequent and early HIV-1MN neutralizing capacity in sera from Dutch HIV-1 seroconverters is related to antibody reactivity to peptides from the gp120 V3 domain. AIDS RES HUM RETROV 1994;10 (3):245-251 [PubMed]
Zwart G, van der Hoek L, Valk M, Cornelissen MT, Baan E, Dekker J, Koot M, Kuiken CL, Goudsmit J, ANTIBODY-RESPONSES TO HIV-1 ENVELOPE AND GAG EPITOPES IN HIV-1 SEROCONVERTERS WITH RAPID VERSUS SLOW DISEASE PROGRESSION. VIROLOGY 1994;201 (2):285-293 [PubMed]
Zwart G, Wolfs TF, Valk M, van der Hoek L, Kuiken CL, Goudsmit J, Characterization of the specificity of the human antibody response to the V3 neutralization domain of HIV-1. AIDS RES HUM RETROV 1992;8 (11):1897-1908 [PubMed]
Zwart G, Langedijk H, van der Hoek L, de Jong JJ, Wolfs TF, Ramautarsing C, Bakker M, de Ronde A, Goudsmit J, Immunodominance and antigenic variation of the principal neutralization domain of HIV-1. VIROLOGY 1991;181 (2):481-489 [PubMed]
Goudsmit J, Boucher CA, Meloen RH, Epstein LG, Smit L, van der Hoek L, Bakker M, Human antibody response to a strain-specific HIV-1 gp120 epitope associated with cell fusion inhibition. AIDS 1988;2 (3):157-164 [PubMed]
Key publications

de Groof A, Guelen L, Deijs M, van der Wal Y, Miyata M, Ng KS, van Grinsven L, Simmelink B, Biermann Y, Grisez L, van Lent J, de Ronde A, Chang SF, Schrier C, van der Hoek L, A Novel Virus Causes Scale Drop Disease in Lates calcarifer. PLOS PATHOG 2015;11 (8):e1005074 [PubMed]
Oude Munnink BB, Canuti M, Deijs M, de Vries M, Jebbink MF, Rebers S, Molenkamp R, van Hemert FJ, Chung K, Cotten M, Snijders F, Sol CJA, van der Hoek L, Unexplained diarrhoea in HIV-1 infected individuals. BMC INFECT DIS 2014;14 (1):22 [PubMed]
Dijkman R, Jebbink MF, Koekkoek SM, Deijs M, Jónsdóttir HR, Molenkamp R, Ieven M, Goossens H, Thiel V, van der Hoek L, Isolation and characterization of current human coronavirus strains in primary human epithelial cell cultures reveal differences in target cell tropism. J VIROL 2013;87 (11):6081-6090 [PubMed]
de Vries M, Deijs M, Canuti M, van Schaik BDC, Faria NR, van de Garde MDB, Jachimowski LCM, Jebbink MF, Jakobs M, Luyf ACM, Coenjaerts FEJ, Claas ECJ, Molenkamp R, Koekkoek SM, Lammens C, Leus F, Goossens H, Ieven M, Baas F, van der Hoek L, A Sensitive Assay for Virus Discovery in Respiratory Clinical Samples. PLOS ONE 2011;6 (1):e16118 [PubMed]
van der Hoek L, Pyrc K, Jebbink MF, Vermeulen-Oost W, Berkhout RJM, Wolthers KC, Wertheim-van Dillen PME, Kaandorp J, Spaargaren J, Berkhout B, Identification of a new human coronavirus. NAT MED 2004;10 (4):368-373 [PubMed]


All Publications

Research programmes

Virus Discovery and Viromics


Identification and characterisation of novel viruses involved in human disease


Funding is received from European Union H2020 programme:

  • HONOURs: an EU Horizon 2020 Marie Skłodowska-Curie project on host switching pathogens, infectious outbreaks and zoonosis; Project 721367. www.honours.eu 

 

Faculty
Dr. C.M. van der Hoek PhD
Drs. B.B. Oude Munnink MSc

Postdocs
Dr. mr. S.M. Jazaeri Farsani PhD

PhD Students
A.W.D. Edridge MD
L. Falk
C.M. Kinsella MSc
R.J. Overmars

Others
M. Deijs BSc
M.F. Jebbink BSc

Other research related activities
  • None reported
Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • Department of Zoology, Oxford University
  • Europese Unie
  • Intervet International B.V.
  • Vaxxinova International BV