• Principal Investigator
  • Male

Prof. dr. C. Ince

Position: Professor
Main activities: Research
Specialisation: Cardiovascular aspects of surgery and intensive care medicine
foto C. Ince is one of the AMC Principal Investigators
Focus of research:

Cardiovascular aspects of Surgery and Critical Illness.

The Laboratory of Translational Physiology at the Academic Medical Center is dedicated to research into cardiovascular aspects of perioperative medicine (e.g. surgery and intensive care medicine) with an emphasis on organ function, (micro)circulation and cellular and mitochondrial oxygenation. Its research is strongly translational where (pahto)physiological and therapeutic concepts were developed in the laboratory are applied to clinical practice. Research topics include sepsis, acute kidney injury, myocardial depression, ischemia reperfussion, hemorheology, resuscitation and fluid therapy related to surgery and critical care medicine. Basic science interests related to these subjects are focused on renal and heart failure, red blood cell (pahto)physiology, cellular oxygen metabolism, nitric oxide and oxygen radical species and mitochondiral oxygenation and bioenergetics. To carry out these investigations and conduct translational research from bench to bedside we also carry out Research and development on clinical and experimental medical technology which are directed at optical spectroscopy of tissue and mitochondrial oxygenation and clinical microcirculation imaging

AMC themes: Cardiovascular Diseases
Departments: Biomedical Engineering and Physics: Translational Physiology
Daeichin V, van Rooij T, Skachkov I, Ergin B, Specht PAC, Lima A, Ince C, Bosch JG, van der Steen AFW, de Jong N, Kooiman K, Microbubble Composition and Preparation for High-Frequency Contrast-Enhanced Ultrasound Imaging: In Vitro and In Vivo Evaluation. IEEE T ULTRASON FERR 2017;64 (3):555-567 [PubMed]
Erdem Ö, Kuiper JW, Ince C, Tibboel D, Videomicroscopic investigation of the microcirculation requires uniform definitions. PHYSIOL REP 2017;5 (11):e13303 [PubMed]
Ergin B, Heger M, Kandil A, Demirci-Tansel C, Ince C, Mycophenolate mofetil improves renal haemodynamics, microvascular oxygenation, and inflammation in a rat model of supra-renal aortic clamping-mediated renal ischaemia reperfusion injury. CLIN EXP PHARMACOL P 2017;44 (2):294-304 [PubMed]
Ferrara G, Edul VSK, Canales HS, Martins E, Canullán C, Murias G, Pozo MO, Caminos Eguillor JF, Buscetti MG, Ince C, Dubin A, Systemic and microcirculatory effects of blood transfusion in experimental hemorrhagic shock. INTENSIVE CARE MED EXP 2017;5 (1):24 [PubMed]
Gruartmoner G, Mesquida J, Ince C, Microcirculatory monitoring in septic patients: Where do we stand?. MED INTENSIVA 2017;41 (1):44-52 [PubMed]
Guerci P, Ince Y, Heeman P, Faber D, Ergin B, Ince C, A LED-based phosphorimeter for measurement of microcirculatory oxygen pressure. J APPL PHYSIOL 2017;122 (2):307-316 [PubMed]
He HW, Liu DW, Ince C, Understanding elevated Pv-aCO2 gap and Pv-aCO2/Ca-vO2 ratio in venous hyperoxia condition. J CLIN MONIT COMPUT 2017;ahead of print [PubMed]
Hilty MP, Pichler J, Ergin B, Hefti U, Merz TM, Ince C, Maggiorini M, Assessment of endothelial cell function and physiological microcirculatory reserve by video microscopy using a topical acetylcholine and nitroglycerin challenge. INTENSIVE CARE MED EXP 2017;5 (1):26 [PubMed]
Ince C, Blood Transfusions Correct Anemia and Improve Tissue Oxygenation in Surgical and Critically ill Patients. TURK J ANAESTHESIOL REANIM 2017;45 (3):119-121 [PubMed]
Ince C, Intensive care medicine in 2050: the ICU in vivo. INTENS CARE MED 2017;ahead of print [PubMed]
Sorelli M, Ince C, Bocchi L, Particle tracking for the assessment of microcirculatory perfusion. PHYSIOL MEAS 2017;38 (2):358-373 [PubMed]
Uz Z, Milstein DMJ, Ince C, de Mol BAJM, Circulating microaggregates during cardiac surgery precedes postoperative stroke. J THROMB THROMBOLYS 2017;44 (1):14-18 [PubMed]
Veenstra G, Pranskunas A, Skarupskiene I, Pilvinis V, Hemmelder MH, Ince C, Boerma EC, Ultrafiltration rate is an important determinant of microcirculatory alterations during chronic renal replacement therapy. BMC NEPHROL 2017;18 (1):71 [PubMed]
Akin S, Ince C, Dos Reis Miranda D. Cardiovascular Response to ECMO in: Vincent JL, editor. Annual Update in Intensive Care and Emergency Medicine 2016. Switzerland: Springer International Publishing; 2016. VI, p. 185-194
Akin S, Kara A, den Uil CA, Ince C, The response of the microcirculation to mechanical support of the heart in critical illness. BEST PRACT RES-CLIN 2016;30 (4):511-522 [PubMed]
Aksu U, Bezemer R, Yavuz B, Demirci C, Ince C, The effects of balanced crystalloid resuscitation in a near-fatal model of hemorrhagic shock on renal oxygenation, nitric oxide metabolism, and reactive oxygen species. SHOCK 2016;-:---
Ashruf JF, Ince C, Myocardial Microcirculation and Mitochondrial Energetics in the Isolated Rat Heart. ADV EXP MED BIOL 2016;876:159-165 [PubMed]
Basile DP, Bonventre JV, Mehta R, Nangaku M, Unwin R, Rosner MH, Kellum JA, Ronco C [Contributors: Kellum J, Okusa M, Ronco C, Rosner M, Agarwal A, Basile DP, Blantz R, Bonventre JV, Cantaluppi V, Chawla LS, Dong Z, Griffin M, Harris R, Humphreys B, Ince C, Matejovic M, McKay D, Mehta R, Molitoris B, Murray P, Nangaku M, Pickkers P, Portilla D, Rabb H, Singbartl K, Swaminathan S, Unwin R, Yang L]] , Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments. J AM SOC NEPHROL 2016;27 (3):687-697 [PubMed]
Damiani E, Ince C, Orlando F, Pierpaoli E, Cirioni O, Giacometti A, Mocchegiani F, Pelaia P, Provinciali M, Donati A, Effects of the Infusion of 4% or 20% Human Serum Albumin on the Skeletal Muscle Microcirculation in Endotoxemic Rats. PLOS ONE 2016;11 (3):e0151005 [PubMed]
Damiani E, Ince C, Scorcella C, Domizi R, Carsetti A, Mininno N, Pierantozzi S, Adrario E, Romano R, Pelaia P, Donati A, Impact of microcirculatory video quality on the evaluation of sublingual microcirculation in critically ill patients. J CLIN MONIT COMPUT 2016;ahead of print [PubMed]
Donati A. From macrohemodynamic to the microcirculation. S.l.: s.n.; 2016. 281p. ISBN 978-94-6182-705-0 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Ince C; copromotor(s): )
Edul VSK, Ince C, Vazquez AR, Rubatto PN, Espinoza EDV, Welsh S, Enrico C, Dubin A, Similar Microcirculatory Alterations in Patients with Normodynamic and Hyperdynamic Septic Shock. ANN AM THORAC SOC 2016;13 (2):240-247 [PubMed]
Ergin B, Guerci P, Zafrani L, Nocken F, Kandil A, Gurel-Gurevin E, Demirci-Tansel C, Ince C, Effects of N-acetylcysteine (NAC) supplementation in resuscitation fluids on renal microcirculatory oxygenation, inflammation, and function in a rat model of endotoxemia. INTENSIVE CARE MED EXP 2016;4 (1):29 [PubMed]
Ergin B, Kapucu A, Guerci P, Ince C, The role of bicarbonate precursors in balanced fluids during haemorrhagic shock with and without compromised liver function. BRIT J ANAESTH 2016;117 (4):521-528 [PubMed]
Ergin B, Zafrani L, Kandil A, Baasner S, Lupp C, Demirci C, Westphal M, Ince C, Fully Balanced Fluids do not Improve Microvascular Oxygenation, Acidosis and Renal Function in a Rat Model of Endotoxemia. SHOCK 2016;46 (1):83-91 [PubMed]
Ferrara G, Kanoore Edul VS, Martins E, Canales HS, Canullán C, Murias G, Pozo MO, Estenssoro E, Ince C, Dubin A, Intestinal and sublingual microcirculation are more severely compromised in hemodilution than in hemorrhage. J APPL PHYSIOL 2016;120 (10):1132-1140 [PubMed]
Gilbert-Kawai E, Coppel J, Bountziouka V, Ince C, Martin D [Contributors: Ahuja V, Aref-Adib G, Burnham R, Chisholm A, Clarke K, Coates D, Coates M, Cook D, Cox M, Dhillon S, Dougall C, Doyle P, Duncan P, Edsell M, Edwards L, Evans L, Gardiner P, Grocott M, Gunning P, Hart N, Harrington J, Harvey J, Holloway C, Howard D, Hurlbut D, Imray C, Ince C, Jonas M, van der Kaaij J, Khosravi M, Kolfschoten N, Levett D, Luery H, Luks A, Martin D, McMorrow R, Meale P, Mitchell K, Montgomery H, Morgan G, Morgan J, Murray A, Mythen M, Newman S, O'Dwyer M, Pate J, Plant T, Pun M, Richards P, Richardson A, Rodway G, Simpson J, Stroud C, Stroud M, Stygal J, Symons B, Szawarski P, van Tulleken A, van Tulleken C, Vercueil A, Wandrag L, Wilson M, Windsor J, Basnyat B, Clarke C, Hornbein T, Milledge J, West J, Abraham S, Adams T, Anseeuw W, Astin R, Burdall O, Carroll J, Cobb A, Coppel J, Couppis O, Court J, Cumptsey A, Davies T, Diamond N, Geliot T, Gilbert-Kawai E, Gilbert-Kawai G, Gnaiger E, Haldane C, Hennis P, Horscroft J, Jack S, Jarvis B, Jenner W, Jones G, Kenth J, Kotwica A, Kumar RBC, Lacey J, Laner V, Mahomed Z, Moonie J, Mythen P, O'Brien K, Ruggles-Brice I, Salmon K, Sheperdigian A, Smedley T, Tomlinson C, Ward S, Wight A, Wilkinson C, Wythe S, Feelisch M, Hanson M, Moon R, Peters M]] , A comparison of the quality of image acquisition between the incident dark field and sidestream dark field video-microscopes. BMC MED IMAGING 2016;16 (1):10 [PubMed]
Gilbert-Kawai E, Coppel J, Phillip H, Grocott M, Ince C, Martin D, Changes in labial capillary density on ascent to and descent from high altitude. F1000RES 2016;5:2107 [PubMed]
Humphreys BD, Cantaluppi V, Portilla D, Singbartl K, Yang L, Rosner MH, Kellum JA, Ronco C [Contributors: Okusa M, Rosner MH, Kellum JA, Ronco C, Agarwal A, Basile DP, Blantz R, Bonventre JV, Chawla LS, Dong Z, Griffin M, Harris R, Ince C, Matejovic M, McKay D, Mehta R, Molitoris B, Murray P, Nangaku M, Pickkers P, Rabb H, Swaminathan S, Unwin R, Humphreys BD, Cantaluppi V, Portilla D, Singbartl K, Yang L]] , Targeting Endogenous Repair Pathways after AKI. J AM SOC NEPHROL 2016;27 (4):990-998 [PubMed]
Ince C, Ertmer C, Hemodynamic coherence: Its meaning in perioperative and intensive care medicine Preface. BEST PRACT RES-CLIN 2016;30 (4):395-397 [PubMed]
Ince C, Guerci P, Why and when the microcirculation becomes disassociated from the macrocirculation. INTENS CARE MED 2016;42 (10):1645-1646 [PubMed]
Ince C, Mayeux PR, Nguyen T, Gomez H, Kellum JA, Ospina-Tascón GA, Hernandez G, Murray P, de Backer D, THE ENDOTHELIUM IN SEPSIS. SHOCK 2016;45 (3):259-270 [PubMed]
Ince C, Mik EG, Microcirculatory and mitochondrial hypoxia in sepsis, shock, and resuscitation. J APPL PHYSIOL 2016;120 (2):226-235 [PubMed]
Kara A, Akin S, Dos Reis Miranda D, Struijs A, Caliskan K, van Thiel RJ, Dubois EA, de Wilde W, Zijlstra F, Gommers D, Ince C, Microcirculatory assessment of patients under VA-ECMO. CRIT CARE 2016;20 (1):344 [PubMed]
Kara A, Akin S, Ince C, Monitoring microcirculation in critical illness. CURR OPIN CRIT CARE 2016;22 (5):444-452 [PubMed]
Kara A, Akin S, Ince C, The response of the microcirculation to cardiac surgery. CURR OPIN ANESTHESIO 2016;29 (1):85-93 [PubMed]
Kuiper JW, Tibboel D, Ince C, The vulnerable microcirculation in the critically ill pediatric patient. CRIT CARE 2016;20 (1):352 [PubMed]
Legrand M , Ince C, Intravenous Fluids in AKI: A Mechanistically Guided Approach. SEMIN NEPHROL 2016;36 (1):53-61 [PubMed]
Matejovic M, Ince C, Chawla LS, Blantz R, Molitoris BA, Rosner MH, Okusa MD, Kellum JA, Ronco C [Contributors: Kellum J, Okusa M, Ronco C, Rosner M, Agarwal A, Basile DP, Blantz R, Bonventre JV, Cantaluppi V, Chawla LS, Dong Z, Griffin M, Harris R, Humphreys B, Ince C, Matejovic M, McKay D, Mehta R, Molitoris B, Murray P, Nangaku M, Pickkers P, Portilla D, Rabb H, Singbartl K, Swaminathan S, Unwin R, Yang L]] , Renal Hemodynamics in AKI: In Search of New Treatment Targets. J AM SOC NEPHROL 2016;27 (1):49-58 [PubMed]
Milstein DMJ, Ince C, Gisbertz SS, Boateng KB, Geerts BF, Hollmann MW, van Berge Henegouwen MI, Veelo DP, Laser speckle contrast imaging identifies ischemic areas on gastric tube reconstructions following esophagectomy. MEDICINE 2016;95 (25):e3875 [PubMed]
Ocak I, Kara A, Ince C, Monitoring microcirculation. BEST PRACT RES-CLIN 2016;30 (4):407-418 [PubMed]
Okusa MD, Rosner MH, Kellum JA, Ronco C [Contributors: Kellum J, Okusa M, Ronco C, Rosner M, Agarwal A, Basile DP, Blantz R, Bonventre JV, Cantaluppi V, Chawla LS, Dong Z, Griffin M, Harris R, Humphreys B, Ince C, Matejovic M, McKay D, Mehta R, Molitoris B, Murray P, Nangaku M, Pickkers P, Portilla D, Rabb H, Singbartl K, Swaminathan S, Unwin R, Yang L]] , Therapeutic Targets of Human AKI: Harmonizing Human and Animal AKI. J AM SOC NEPHROL 2016;27 (1):44-48 [PubMed]
Peters E, Ergin B, Kandil A, Gurel-Gurevin E, van Elsas A, Masereeuw R, Pickkers P, Ince C, Effects of a human recombinant alkaline phosphatase on renal hemodynamics, oxygenation and inflammation in two models of acute kidney injury. TOXICOL APPL PHARM 2016;313:88-96 [PubMed]
Rabb H, Griffin MD, McKay DB, Swaminathan S, Pickkers P, Rosner MH, Kellum JA, Ronco C [Contributors: Kellum J, Okusa M, Ronco C, Rosner M, Agarwal A, Basile DP, Blantz R, Bonventre JV, Cantaluppi V, Chawla LS, Dong Z, Griffin M, Harris R, Humphreys B, Ince C, Matejovic M, McKay D, Mehta R, Molitoris B, Murray P, Nangaku M, Pickkers P, Portilla D, Rabb H, Singbartl K, Swaminathan S, Unwin R, Yang L]] , Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps. J AM SOC NEPHROL 2016;27 (2):371-379 [PubMed]
van Elteren HA, de Jonge RCJ, van Rosmalen J, Ince C, Reiss IKM, Adaptation of the Cutaneous Microcirculation in Preterm Neonates. MICROCIRCULATION 2016;23 (6):468-474 [PubMed]
Weber MA, Diedrich CM, Ince C, Roovers JP, Focal depth measurements of the vaginal wall: a new method to noninvasively quantify vaginal wall thickness in the diagnosis and treatment of vaginal atrophy. MENOPAUSE 2016;23 (8):833-838 [PubMed]
Weber MA, Milstein DMJ, Ince C, Roovers JPWR, Is pelvic organ prolapse associated with altered microcirculation of the vaginal wall?. NEUROUROL URODYNAM 2016;35 (7):764-770 [PubMed]
Yuruk K, Bezemer R, Euser M, Milstein DM, Almac E, van den Brink A , Scholten EW, de Mol BAJM, Ince C, Conventional versus miniaturized ECC during CABG surgery and the effects on the microcirculation.. ANN THORAC SURG 2016;-:----
Zafrani L, Ergin B, Kapucu A, Ince C, Blood transfusion improves renal oxygenation and renal function in sepsis-induced acute kidney injury in rats. CRIT CARE 2016;20 (1):406 [PubMed]
Aksu U. Renal perfusion and oxygenation during acute kidney injury. S.l.: s.n.; 2015. 150p. ISBN 978-94-91715-08-2 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Ince C; copromotor(s): Bezemer R)
Aksu U, Ergin B, Bezemer R, Kandil A, Milstein DMJ, Demirci-Tansel C, Ince C, Scavenging reactive oxygen species using tempol in the acute phase of renal ischemia/reperfusion and its effects on kidney oxygenation and nitric oxide levels. INTENSIVE CARE MED EXP 2015;3 (1):57 [PubMed]
Ashruf JF. Myocardial microcirculation and mitochondrial energetics in the isolated rat heart. S.l.: s.n.; 2015. 152p. ISBN 978-94-91715-07-5 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Ince C; copromotor(s): Zuurbier CJ, Milstein DMJ)
Aykut G, Veenstra G, Scorcella C, Ince C, Boerma C, Cytocam-IDF (incident dark field illumination) imaging for bedside monitoring of the microcirculation. INTENSIVE CARE MED EXP 2015;3 (1):40 [PubMed]
Balestra GM, Aalders MCG, Specht PAC, Ince C, Mik EG, Oxygenation measurement by multi-wavelength oxygen-dependent phosphorescence and delayed fluorescence: catchment depth and application in intact heart. J BIOPHOTONICS 2015;8 (8):615-628 [PubMed]
Damiani E, Adrario E, Luchetti MM, Scorcella C, Carsetti A, Mininno N, Pierantozzi S, Principi T, Strovegli D, Bencivenga R, Gabrielli A, Romano R, Pelaia P, Ince C, Donati A, Plasma free hemoglobin and microcirculatory response to fresh or old blood transfusions in sepsis. PLOS ONE 2015;10 (5):e0122655 [PubMed]
Ergin B, Kapucu A, Demirci-Tansel C, Ince C, The renal microcirculation in sepsis. NEPHROL DIAL TRANSPL 2015;30 (2):169-177 [PubMed]
Ferrara G, Kanoore Edul VS, Caminos Eguillor JF, Martins E, Canullán C, Canales HS, Ince C, Estenssoro E, Dubin A, Effects of norepinephrine on tissue perfusion in a sheep model of intra-abdominal hypertension. INTENSIVE CARE MED EXP 2015;3 (1):46 [PubMed]
Gruartmoner G, Mesquida J, Ince C, Fluid therapy and the hypovolemic microcirculation. CURR OPIN CRIT CARE 2015;21 (4):276-284 [PubMed]
Ince C, Hemodynamic coherence and the rationale for monitoring the microcirculation. CRIT CARE 2015;19 (3):S8 [PubMed]
Ince C, To beta block or not to beta block; that is the question. CRIT CARE 2015;19 (1):339 [PubMed]
Kanoore Edul VS, Ince C, Dubin A, What is microcirculatory shock?. CURR OPIN CRIT CARE 2015;21 (3):245-252 [PubMed]
Kanoore Edul VS, Ince C, Estenssoro E, Ferrara G, Arzani Y, Salvatori C, Dubin A, The Effects of Arterial Hypertension and Age on the Sublingual Microcirculation of Healthy Volunteers and Outpatients with Cardiovascular Risk Factors. MICROCIRCULATION 2015;22 (6):485-492 [PubMed]
López A, Grignola JC, Angulo M, Alvez I, Nin N, Lacuesta G, Baz M, Cardinal P, Prestes I, Bouchacourt JP, Riva J, Ince C, Hurtado FJ, Effects of early hemodynamic resuscitation on left ventricular performance and microcirculatory function during endotoxic shock. INTENSIVE CARE MED EXP 2015;3 (1):49 [PubMed]
Marini JJ, Gattinoni L, Ince C, Kozek-Langenecker S, Mehta RL, Pichard C, Westphal M, Wischmeyer P, Vincent JL, A few of our favorite unconfirmed ideas. CRIT CARE 2015;19 (3):S1 [PubMed]
Meinders AJ, Nieuwenhuis L, Ince C, Bos WJ, Elbers PWG, Haemodialysis Impairs the Human Microcirculation Independent from Macrohemodynamic Parameters. BLOOD PURIFICAT 2015;40 (1):38-44 [PubMed]
Pérez-Bárcena J, Romay E, Llompart-Pou JA, Ibáñez J, Brell M, Llinás P, González E, Merenda A, Ince C, Bullock R, Direct observation during surgery shows preservation of cerebral microcirculation in patients with traumatic brain injury. J NEUROL SCI 2015;353 (1-2):38-43 [PubMed]
Sorelli M, Bocchi L, Ince C, Monitoring the microcirculation at the bedside using hand-held imaging microscopes: Automatic tracking of erythrocytes. CONF PROC IEEE ENG MED BIOL SOC 2015;2015:7378-7381 [PubMed]
van den Berg VJ, van Elteren HA, Buijs EAB, Ince C, Tibboel D, Reiss IKM, de Jonge RCJ, Reproducibility of Microvascular Vessel Density Analysis in Sidestream Dark-Field-Derived Images of Healthy Term Newborns. MICROCIRCULATION 2015;22 (1):37-43 [PubMed]
van Elteren HA, Ince C, Tibboel D, Reiss IKM, de Jonge RCJ, Cutaneous microcirculation in preterm neonates: comparison between sidestream dark field (SDF) and incident dark field (IDF) imaging. J CLIN MONIT COMPUT 2015;29 (5):543-548 [PubMed]
Vellinga NAR, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Machado FR, Fries M, Akarsu-Ayazoglu T, Pranskunas A, Hollenberg S, Balestra G , van Iterson M, van der Voort PHJ, Sadaka F, Minto G, Aypar U, Hurtado FJ, Martinelli G, Payen D, van Haren F, Holley A, Pattnaik R, Gomez H, Mehta RL, Rodriguez AH, Ruiz C, Canales HS, Duranteau J, Spronk PE, Jhanji S, Hubble S, Chierego M, Jung C, Martin D, Sorbara C, Tijssen JGP, Bakker J, Ince C [Contributors: Boerma EC, Koopmans M, Vellinga NAR , van Iterson M, van der Voort PHJ, Bakker J, van Bommel J, Ince C, Spronk PE, Ruiz C, Hernandez G, Machado FR, Bafi AT, Dubin A, Kanoore Edul VS, Canales HS, Hurtado FJ, Lacuesta G, Baz M, Hollenberg SM, Patel U, Shapiro NI, Gomez H, Simon P, Pinsky M, Sadaka FG, Krause K, Mehta R, Jung C, Fries M, Pearse RM, Smith A, Martin DS, Meale P, Jhanji S, Minto G, Lai C, Ferguson C, McMillan H, Quintrell T, Sair M, Martinelli G, Lombrano M, Hubble SMA, Thorn C, Rodriguez AH, Martin-Loeches I, van Haren FMP, Pranskunas A, Pilvinis V, Donati A, Sorbara C, Forti A, Comin A, Chierego ML, Pellis T, Holley A, Paratz J, Duranteau J, Harrois A, Payen D, Legrand M, Balestra GM, Bucher E, Pattnaik R, Dondorp AM, Herdman MT, Aypar U, Ayhan B, Ayazoglu-Akarsu T]] , International study on microcirculatory shock occurrence in acutely ill patients. CRIT CARE MED 2015;43 (1):48-56 [PubMed]
Vellinga NAR, Veenstra G, Scorcella C, Koopmans M, van Roon EN, Ince C, Boerma EC, Effects of ketanserin on microcirculatory alterations in septic shock: An open-label pilot study. J CRIT CARE 2015;30 (6):1156-1162 [PubMed]
Weber MA, Milstein DMJ, Ince C, Oude Rengerink K, Roovers JPWR, Vaginal microcirculation: Non-invasive anatomical examination of the micro-vessel architecture, tortuosity and capillary density. NEUROUROL URODYNAM 2015;34 (8):723-729 [PubMed]
Zafrani L, Ince C, Microcirculation in Acute and Chronic Kidney Diseases. AM J KIDNEY DIS 2015;66 (6):1083-1094 [PubMed]
Zafrani L, Payen D, Azoulay E, Ince C, The microcirculation of the septic kidney. SEMIN NEPHROL 2015;35 (1):75-84 [PubMed]
Almac E. Therapeutic strategies for the protection of renal oxygenation in experimental models of acute kidney injury. S.l.: s.n.; 2014. 156p. ISBN 9789090285023 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Ince C; copromotor(s): Bezemer R, van Iterson M)
Almac E, Bezemer R, Hilarius-Stokman PM, Goedhart P, de Korte D, Verhoeven AJ, Ince C, Red blood cell storage increases hypoxia-induced nitric oxide bioavailability and methemoglobin formation in vitro and in vivo. TRANSFUSION 2014;54 (12):3178-3185 [PubMed]
Almac E, Bezemer R, Kandil A, Aksu U, Milstein DMJ, Bakker J, Demirci-Tansel C, Ince C, Bis maltolato oxovanadium (BMOV) and ischemia/reperfusion-induced acute kidney injury in rats. INTENSIVE CARE MED EXP 2014;2 (1):6 [PubMed]
Bikker IG, Holland W, Specht P, Ince C, Gommers D, Assessment of ventilation inhomogeneity during mechanical ventilation using a rapid-response oxygen sensor-based oxygen washout method. INTENSIVE CARE MED EXP 2014;2 (1):11 [PubMed]
Buijs EAB, Reiss IKM, Kraemer U, Andrinopoulou ER, Zwiers AJM, Ince C, Tibboel D, Increasing mean arterial blood pressure and heart rate with catecholaminergic drugs does not improve the microcirculation in children with congenital diaphragmatic hernia: a prospective cohort study. PEDIATR CRIT CARE ME 2014;15 (4):343-354 [PubMed]
Buijs EAB, Verboom EM, Top APC, Andrinopoulou ER, Buysse CMP, Ince C, Tibboel D, Early microcirculatory impairment during therapeutic hypothermia is associated with poor outcome in post-cardiac arrest children: a prospective observational cohort study. RESUSCITATION 2014;85 (3):397-404 [PubMed]
Buijs EA, Houmes RJ, Rizopoulos D, Wildschut ED, Reiss IK, Ince C, Tibboel D, Arterial lactate for predicting mortality in children requiring extracorporeal membrane oxygenation. MINERVA ANESTESIOL 2014;80 (12):1282-1293 [PubMed]
Chawla LS, Ince C, Chappell D, Gan TJ, Kellum JA, Mythen M, Shaw AD, Vascular content, tone, integrity, and haemodynamics for guiding fluid therapy: a conceptual approach. BRIT J ANAESTH 2014;113 (5):748-755 [PubMed]
Donati A, Damiani E, Luchetti M, Domizi R, Scorcella C, Carsetti A, Gabbanelli V, Carletti P, Bencivenga R, Vink H, Adrario E, Piagnerelli M, Gabrielli A, Pelaia P, Ince C, Microcirculatory effects of the transfusion of leukodepleted or non-leukodepleted red blood cells in patients with sepsis: a pilot study. CRIT CARE 2014;18 (1):R33 [PubMed]
Gomez H, Ince C, de Backer D, Pickkers P, Payen D, Hotchkiss J, Kellum JA, A unified theory of sepsis-induced acute kidney injury: inflammation, microcirculatory dysfunction, bioenergetics, and the tubular cell adaptation to injury. SHOCK 2014;41 (1):3-11 [PubMed]
Hernandez G, Luengo C, Bruhn A, Kattan E, Friedman G, Ospina-Tascon GA, Fuentealba A, Castro R, Regueira T, Romero C, Ince C, Bakker J, When to stop septic shock resuscitation: clues from a dynamic perfusion monitoring. ANN INTENSIVE CARE 2014;4:30 [PubMed]
Ince C, The central role of renal microcirculatory dysfunction in the pathogenesis of acute kidney injury. NEPHRON CLIN PRACT 2014;127 (1-4):124-128 [PubMed]
Ince C, The rationale for microcirculatory guided fluid therapy. CURR OPIN CRIT CARE 2014;20 (3):301-308 [PubMed]
Ince C, Groeneveld ABJ, The case for 0.9% NaCl: is the undefendable, defensible?. KIDNEY INT 2014;86 (6):1087-1095 [PubMed]
Kanoore Edul VS, Ince C, Navarro N, Previgliano L, Risso-Vazquez A, Rubatto PN, Dubin A, Dissociation between sublingual and gut microcirculation in the response to a fluid challenge in postoperative patients with abdominal sepsis. ANN INTENSIVE CARE 2014;4:39 [PubMed]
Murray PT, Mehta RL, Shaw A, Ronco C, Endre Z, Kellum JA, Chawla LS, Cruz D, Ince C, Okusa MD [Contributors: Murray P, Mehta RL, Shaw A, Ronco C, Kellum J, Chawla L, Cruz D, Ince C, Okusa M, Haase M, McCullough P, Bouchard J, Waikar S, Siew E, Goldstein S, Koyner J, Macedo E, Doi K, Di Somma S, Maisel A, Lewington A, Thadhani R, Bagshaw S, Chakravarthi R, Duranteau J, Doran P, Yang L, Jaber B, Clopton P, Bonventre J, Cutter G, Molitoris B, Devarajan P, Fitzgibbon M, Noiri E, Parikh C]] , Potential use of biomarkers in acute kidney injury: report and summary of recommendations from the 10th Acute Dialysis Quality Initiative consensus conference. KIDNEY INT 2014;85 (3):513-521 [PubMed]
Siervo M, Riley HL, Fernandez BO, Leckstrom CA, Martin DS, Mitchell K, Levett DZH, Montgomery HE, Mythen MG, Grocott MPW, Feelisch M [Contributors: Ahuja V, Aref-Adib G, Burnham R, Chisholm A, Clarke K, Coates D, Coates M, Cook D, Cox M, Dhillon S, Dougall C, Doyle P, Duncan P, Edsell M, Edwards L, Evans L, Gardiner P, Grocott M, Gunning P, Hart N, Harrington J, Harvey J, Holloway C, Howard D, Hurlbut D, Imray C, Ince C, Jonas M, van der Kaaij J, Khosravi M, Kolfschoten N, Levett D, Luery H, Luks A, Martin D, McMorrow R, Meale P, Mitchell K, Montgomery H, Morgan G, Morgan J, Murray A, Mythen M, Newman S, O'Dwyer M, Pate J, Plant T, Pun M, Richards P, Richardson A, Rodway G, Simpson J, Stroud C, Stroud M, Stygal J, Symons B, Szawarski P, van Tulleken A, van Tulleken C, Vercueil A, Wandrag L, Wilson M, Windsor J, Basnyat B, Clarke C, Hornbein T, Milledge J, West J]] , Effects of Prolonged Exposure to Hypobaric Hypoxia on Oxidative Stress, Inflammation and Gluco-Insular Regulation: The Not-So-Sweet Price for Good Regulation. PLOS ONE 2014;9 (4):e94915 [PubMed]
Smorenberg A, Ince C, Groeneveld ABJ, Correction: Dose and type of crystalloid fluid therapy in adult hospitalized patients. PERIOPER MED (LOND) 2014;3:3 [PubMed]
van Zijderveld R , Ince C, Schlingemann RO, Orthogonal polarization spectral imaging of conjunctival microcirculation. GRAEF ARCH CLIN EXP 2014;252 (5):773-779 [PubMed]
Veenstra G, Ince C, Boerma EC, Direct markers of organ perfusion to guide fluid therapy: when to start, when to stop. BEST PRACT RES CLIN ANAESTHESIOL 2014;28 (3):217-226 [PubMed]
Vellinga NAR. Microcirculatory dysfunction in critically ill patients: prevalence and significance from a bedside perspective. S.l.: s.n.; 2014. 181p. ISBN 9789462593022 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Ince C; copromotor(s): Boerma EC)
Zafrani L, Ince C, The traumatic microcirculation. CRIT CARE MED 2014;42 (6):1556-1557 [PubMed]
Zarbock A, Eroglu A, Erturk E, Ince C, Westphal M, Ischemia-Reperfusion Injury and Anesthesia. BIOMED RES INT 2014;2014:980318 [PubMed]
Ashruf JF, Bruining HA, Ince C, New insights into the pathophysiology of cardiogenic shock: the role of the microcirculation. CURR OPIN CRIT CARE 2013;19 (5):381-386 [PubMed]
Ayhan B, Yuruk K, Koene S, Sahin A, Ince C, Aypar U, The effects of non-leukoreduced red blood cell transfusions on microcirculation in mixed surgical patients. TRANSFUS APHER SCI 2013;49 (2):212-222 [PubMed]
Donati A, Damiani E, Botticelli L, Adrario E, Lombrano MR, Domizi R, Marini B, van Teeffelen JWGE, Carletti P, Girardis M, Pelaia P, Ince C, The aPC treatment improves microcirculation in severe sepsis/septic shock syndrome. BMC ANESTHESIOL 2013;13 (1):25 [PubMed]
Donati A, Damiani E, Domizi R, Romano R, Adrario E, Pelaia P, Ince C, Singer M, Alteration of the sublingual microvascular glycocalyx in critically ill patients. MICROVASC RES 2013;90:86-89 [PubMed]
Donati A, Domizi R, Damiani E, Adrario E, Pelaia P, Ince C, From Macrohemodynamic to the Microcirculation. CRIT CARE RES PRACT 2013;2013:892710 [PubMed]
Donati A, Tibboel D, Ince C, Towards integrative physiological monitoring of the critically ill: from cardiovascular to microcirculatory and cellular function monitoring at the bedside. CRIT CARE 2013;17 (Suppl. 1):S5 [PubMed]
Driessen C, Plomp RG, van der Spek PJ, Ince C, Kulik W, Mathijssen IMJ, Joosten KFM, Is there an effect of obstructive sleep apnea syndrome on oxidative stress and inflammatory parameters in patients with craniofacial anomalies?. J CRANIOFAC SURG 2013;24 (6):1908-1913 [PubMed]
Evans RG, Ince C, Joles JA, Smith DW, May CN, O'Connor PM, Gardiner BS, Haemodynamic influences on kidney oxygenation: clinical implications of integrative physiology. CLIN EXP PHARMACOL P 2013;40 (2):106-122 [PubMed]
Hernandez G, Boerma EC, Dubin A, Bruhn A, Koopmans M, Edul VK, Ruiz C, Castro R, Pozo MO, Pedreros C, Veas E, Fuentealba A, Kattan E, Rovegno M, Ince C, Severe abnormalities in microvascular perfused vessel density are associated to organ dysfunctions and mortality and can be predicted by hyperlactatemia and norepinephrine requirements in septic shock patients. J CRIT CARE 2013;28 (4):538.e9-538.14 [PubMed]
Hernandez G, Bruhn A, Ince C, Microcirculation in sepsis: new perspectives. CURR VASC PHARMACOL 2013;11 (2):161-169 [PubMed]
Hernandez G, Bruhn A, Luengo C, Regueira T, Kattan E, Fuentealba A, Florez J, Castro R, Aquevedo A, Pairumani R, McNab P, Ince C, Effects of dobutamine on systemic, regional and microcirculatory perfusion parameters in septic shock: a randomized, placebo-controlled, double-blind, crossover study. INTENS CARE MED 2013;39 (8):1435-1443 [PubMed]
Hernández Poblete GW. A holistic approach for perfusion assessment in septic shock. Basic foundations and clinical applications. s.l.: s.n.; 2013. 197p. ISBN 9789461823298 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Ince C, Bakker J; copromotor(s): Bezemer R)
Ince C, The great fluid debate: when will physiology prevail?. ANESTHESIOLOGY 2013;119 (2):248-249 [PubMed]
Klijn E, Hulscher HC, Balvers RK, Holland WPJ, Bakker J, Vincent AJPE, Dirven CMF, Ince C, Laser speckle imaging identification of increases in cortical microcirculatory blood flow induced by motor activity during awake craniotomy. J NEUROSURG 2013;118 (2):280-286 [PubMed]
Lupp C, Baasner S, Ince C, Nocken F, Stover JF, Westphal M, Differentiated control of deranged nitric oxide metabolism: a therapeutic option in sepsis?. CRIT CARE 2013;17 (3):311 [PubMed]
Marini JJ, Vincent JL, Wischmeyer P, Singer M, Gattinoni L, Ince C, Gan TJ, Our favorite unproven ideas for future critical care. CRIT CARE 2013;17 (Suppl. 1):S9 [PubMed]
Meybohm P, van Aken H, de Gasperi A, de Hert S, Della Rocca G, Girbes ARJ, Gombotz H, Guidet B, Hasibeder W, Hollmann MW, Ince C, Jacob M, Kranke P, Kozek-Langenecker S, Loer SA, Martin C, Siegemund M, Wunder C, Zacharowski K, Re-evaluating currently available data and suggestions for planning randomised controlled studies regarding the use of hydroxyethyl starch in critically ill patients - a multidisciplinary statement. CRIT CARE 2013;17 (4):R166 [PubMed]
Milstein DMJ, Cheung YW, Žiūkaitė L, Ince C, van den Akker HP, Lindeboom JAH, An integrative approach for comparing microcirculation between normal and alveolar cleft gingiva in children scheduled for secondary bone grafting procedures. OR SURG OR MED OR PA 2013;115 (3):304-309 [PubMed]
Okusa MD, Jaber BL, Doran P, Duranteau J, Yang L, Murray PT, Mehta RL, Ince C, Physiological biomarkers of acute kidney injury: a conceptual approach to improving outcomes. CONTRIB NEPHROL 2013;182:65-81 [PubMed]
Ruiz C, Hernandez G, Andresen M, Ince C, Bruhn A, Mini-report: Microcirculatory flow abnormalities in a patient with severe hyperviscosity syndrome. CLIN HEMORHEOL MICRO 2013;54 (1):33-38 [PubMed]
Smorenberg A, Ince C, Groeneveld ABJ, Dose and type of crystalloid fluid therapy in adult hospitalized patients. PERIOPER MED (LOND) 2013;2 (1):17 [PubMed]
Tytgat SHAJ, van der Zee DC, Ince C, Milstein DMJ, Carbon dioxide gas pneumoperitoneum induces minimal microcirculatory changes in neonates during laparoscopic pyloromyotomy. SURG ENDOSC 2013;27 (9):3465-3473 [PubMed]
van Genderen ME, Bartels SA, Lima A, Bezemer R, Ince C, Bakker J, van Bommel J, Peripheral perfusion index as an early predictor for central hypovolemia in awake healthy volunteers. ANESTH ANALG 2013;116 (2):351-356 [PubMed]
Vellinga NAR, Ince C, Boerma EC, Elevated central venous pressure is associated with impairment of microcirculatory blood flow in sepsis: a hypothesis generating post hoc analysis. ANESTHESIOLOGY 2013;13 (1):17 [PubMed]
Wilson MH, Davagnanam I, Holland G, Dattani RS, Tamm A, Hirani SP, Kolfschoten N, Strycharczuk L, Green C, Thornton JS, Wright A, Edsell M, Kitchen ND, Sharp DJ, Ham TE, Murray A, Holloway CJ, Clarke K, Grocott MPW, Montgomery H, Imray C [Contributors: Ahuja V, Aref-Adib G, Burnham R, Chisholm A, Clarke K, Coates D, Coates M, Cook D, Cox M, Dhillon S, Dougall C, Doyle P, Duncan P, Edsell M, Edwards L, Evans L, Gardiner P, Grocott M, Gunning P, Hart N, Harrington J, Harvey J, Holloway C, Howard D, Hurlbut D, Imray C, Ince C, Jonas M, van der Kaaij J, Khosravi M, Kolfschoten N, Levett D, Luery H, Luks A, Martin D, McMorrow R, Meale P, Mitchell K, Montgomery H, Morgan G, Morgan J, Murray A, Mythen M, Newman S, O'Dwyer M, Pate J, Plant T, Pun M, Richards P, Richardson A, Rodway G, Simpson J, Stroud C, Stroud M, Stygall J, Symons B, Szawarski P, van Tulleken C, Vercueil A, Wandrag L, Wilson M, Windsor J]] , Cerebral venous system and anatomical predisposition to high-altitude headache. ANN NEUROL 2013;73 (3):381-389 [PubMed]
Yürük K, Milstein DMJ, Bezemer R, Bartels SA, Biemond BJ, Ince C, Transfusion of banked red blood cells and the effects on hemorrheology and microvascular hemodynamics in anemic hematology outpatients. TRANSFUSION 2013;53 (6):1346-1352 [PubMed]
Zafrani L, Ince C, Yuen PST, Microparticles during sepsis: target, canary or cure?. INTENS CARE MED 2013;39 (10):1854-1856 [PubMed]
Aksu U, Bezemer R, Demirci C, Ince C, ACUTE EFFECTS OF BALANCED VERSUS UNBALANCED COLLOID RESUSCITATION ON RENAL MACROCIRCULATORY AND MICROCIRCULATORY PERFUSION DURING ENDOTOXEMIC SHOCK. SHOCK 2012;37 (2):205-209 [PubMed]
Aksu U, Bezemer R, Ince C, Reply to: crystalloid resuscitation in hemorrhagic shock. RESUSCITATION 2012;83 (8):E173 [PubMed]
Aksu U, Bezemer R, Yavuz B, Kandil A, Demirci C, Ince C, Balanced vs unbalanced crystalloid resuscitation in a near-fatal model of hemorrhagic shock and the effects on renal oxygenation, oxidative stress and inflammation. RESUSCITATION 2012;83 (6):767-773 [PubMed]
Almac E, Aksu U, Bezemer R, Jong W, Kandil A, Yuruk K, Demirci-Tansel C, Ince C, The acute effects of acetate-balanced colloid and crystalloid resuscitation on renal oxygenation in a rat model of hemorrhagic shock. RESUSCITATION 2012;83 (9):1166-1172 [PubMed]
Atasever B. The microcirculatory response during cardiac surgery. Amsterdam: PGVO/Ponsen & Looijen; 2012. 119p. ISBN 978-90-8189-530-9 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Ince C Prof.dr.ir., de Mol BAJM; copromotor(s): Boer C)
Atasever B, van der Kuil M, Boer C, Vonk A, Schwarte L, Girbes ARJ, Ince C, Beishuizen A, Groeneveld ABJ, Red blood cell transfusion compared with gelatin solution and no infusion after cardiac surgery: effect on microvascular perfusion, vascular density, hemoglobin, and oxygen saturation. TRANSFUSION 2012;52 (11):2452-2458 [PubMed]
Bezemer R, Bartels SA, Bakker J, Ince C, Clinical review: Clinical imaging of the sublingual microcirculation in the critically ill--where do we stand?. CRIT CARE 2012;16 (3):224 [PubMed]
Bezemer R, Dobbe JG, Bartels SA, Boerma EC, Elbers PWG, Heger M, Ince C, Rapid automatic assessment of microvascular density in sidestream dark field images (vol 49, pg 1269, 2011). MED BIOL ENG COMPUT 2012;50 (10):1115 [PubMed]
Edul VSK, Enrico C, Laviolle B, Vazquez AR, Ince C, Dubin A, Quantitative assessment of the microcirculation in healthy volunteers and in patients with septic shock. CRIT CARE MED 2012;40 (5):1443-1448 [PubMed]
Elbers PWG, Prins WB, Plokker HWM, van Dongen EPA, van Iterson M, Ince C, Electrical Cardioversion for Atrial Fibrillation Improves Microvascular Flow Independent of Blood Pressure Changes. J CARDIOTHOR VASC AN 2012;26 (5):799-803 [PubMed]
Enrico C, Kanoore Edul VS, Vazquez AR, Pein MC, Pérez de la Hoz RA, Ince C, Dubin A, Systemic and microcirculatory effects of dobutamine in patients with septic shock. J CRIT CARE 2012;27 (6):630-638 [PubMed]
Hernandez G, Bruhn A, Castro R, Pedreros C, Rovegno M, Kattan E, Veas E, Fuentealba A, Regueira T, Ruiz C, Ince C, Persistent Sepsis-Induced Hypotension without Hyperlactatemia: A Distinct Clinical and Physiological Profile within the Spectrum of Septic Shock. CRIT CARE RES PRACT 2012;2012:536852 [PubMed]
Hernandez G, Pedreros C, Veas E, Bruhn A, Romero C, Rovegno M, Neira R, Bravo S, Castro R, Kattan E, Ince C, Evolution of peripheral vs metabolic perfusion parameters during septic shock resuscitation. A clinical-physiologic study. J CRIT CARE 2012;27 (3):283-288 [PubMed]
Hernandez G, Regueira T, Bruhn A, Castro R, Rovegno M, Fuentealba A, Veas E, Berrutti D, Kattan E, Martin C, Ince C, Relationship of systemic, hepatosplanchnic, and microcirculatory perfusion parameters with 6-hour lactate clearance in hyperdynamic septic shock patients: an acute, clinical-physiological, pilot study. ANN INTENSIVE CARE 2012;2 (1):44 [PubMed]
Ince C, van Kuijen AM, Milstein DMJ, Yürük K, Folkow LP, Fokkens WJ, Blix AS, CHRISTMAS 2012: RESEARCH Why Rudolph's nose is red: observational study. BMJ-BRIT MED J 2012;345:e8311 [PubMed]
Legrand M , Bezemer R, Ince C, The role of renal hypoperfusion in development of renal microcirculatory dysfunction in endotoxemic rats: reply to Ji et al. INTENS CARE MED 2012;38 (2):336 [PubMed]
McMorrow RCN, Windsor JS, Hart ND, Richards P, Rodway GW, Ahuja VY, O'Dwyer MJ, Mythen MG, Grocott MPW [Contributors: Ahuja V, Aref-Adib G, Burnham R, Chisholm A, Clarke K, Coates D, Coates M, Cook D, Cox M, Dhillon S, Dougall C, Doyle P, Duncan P, Edsell M, Edwards L, Evans L, Gardiner P, Grocott M, Gunning P, Hart N, Harrington J, Harvey J, Holloway C, Howard D, Hurlbut D, Imray C, Ince C, Jonas M, van der Kaaij J, Khosravi M, Kolfschoten N, Levett D, Luery H, Luks A, Martin D, McMorrow R, Meale P, Mitchell K, Montgomery H, Morgan G, Morgan J, Murray A, Mythen M, Newman S, O'Dwyer M, Pate J, Plant T, Pun M, Richards P, Richardson A, Rodway G, Simpson J, Stroud C, Stroud M, Stygal J, Symons B, Szawarski P, van Tulleken A, van Tulleken C, Vercueil A, Wandrag L, Wilson M, Windsor J, Basnyat B, Clarke C, Horn-Bein T, Milledge J, West J]] , Closed and open breathing circuit function in healthy volunteers during exercise at Mount Everest base camp (5300 m). ANAESTHESIA 2012;67 (8):875-880 [PubMed]
Milstein DMJ, van Kuijen AM, Copper MP, Karakullukçu B, Tan IB, Lindeboom JAH, Fokkens WJ, Ince C, Monitoring microcirculatory alterations in oral squamous cell carcinoma following photodynamic therapy. PHOTODIAGN PHOTODYN 2012;9 (1):69-75 [PubMed]
Özarslan NG, Ayhan B, Kanbak M, Çelebioğlu B, Demircin M, Ince C, Aypar Ü, Comparison of the Effects of Sevoflurane, Isoflurane, and Desflurane on Microcirculation in Coronary Artery Bypass Graft Surgery. J CARDIOTHOR VASC AN 2012;26 (5):791-798 [PubMed]
Piagnerelli M, Ince C, Dubin A, Microcirculation. CRIT CARE RES PRACT 2012;2012:867176 [PubMed]
Pozo MO, Kanoore Edul VS, Ince C, Dubin A, Comparison of different methods for the calculation of the microvascular flow index. CRIT CARE RES PRACT 2012;2012:102483 [PubMed]
Smeele KM, Eerbeek O , Schaart G, Koeman A, Bezemer R, Nelson JK, Ince C, Nederlof R, Boek M, Laakso M, de Haan A, Drost MR, Hollmann MW, Zuurbier CJ, Reduced hexokinase II impairs muscle function 2 wk after ischemia-reperfusion through increased cell necrosis and fibrosis. J APPL PHYSIOL 2012;113 (4):608-618 [PubMed]
Top APC, Buijs EAB, Schouwenberg PHM, van Dijk M, Tibboel D, Ince C, The Microcirculation Is Unchanged in Neonates with Severe Respiratory Failure after the Initiation of ECMO Treatment. CRIT CARE RES PRACT 2012;2012:372956 [PubMed]
van Iterson M. Functional heterogeneity of oxygen supply with blood and hemoglobin-based oxygen carriers in porcine models of hemorrhagic shock. Amsterdam: Lecturis Eindhoven; 2012. 165p. ISBN 978-90-70108-79-3 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Ince C; copromotor(s): Bezemer R, van Dongen HPA)
van Iterson M, Bezemer R, Heger M, Siegemund M, Ince C, Microcirculation follows macrocirculation in heart and gut in the acute phase of hemorrhagic shock and isovolemic autologous whole blood resuscitation in pigs. TRANSFUSION 2012;52 (7):1552-1559 [PubMed]
Vellinga NAR, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Bakker J, Ince C, Study Design of the Microcirculatory Shock Occurrence in Acutely Ill Patients (microSOAP): an International Multicenter Observational Study of Sublingual Microcirculatory Alterations in Intensive Care Patients. CRIT CARE RES PRACT 2012;2012:121752 [PubMed]
Vincent JL, Ince C, Bakker J, Clinical review: Circulatory shock--an update: a tribute to Professor Max Harry Weil. CRIT CARE 2012;16 (6):239 [PubMed]
Yuruk K, Bartels SA, Milstein DMJ, Bezemer R, Biemond BJ, Ince C, Red blood cell transfusions and tissue oxygenation in anemic hematology outpatients. TRANSFUSION 2012;52 (3):641-646 [PubMed]
Yuruk K, Bezemer R, Euser M, Milstein DMJ, de Geus HHR, Scholten EW, de Mol BAJM, Ince C, The effects of conventional extracorporeal circulation versus miniaturized extracorporeal circulation on microcirculation during cardiopulmonary bypass-assisted coronary artery bypass graft surgery. INTERACT CARDIOV TH 2012;15 (3):364-370 [PubMed]
Yuruk K, Bezemer R, Ince C. The ability of red blood cell transfusions to reach the microcirculation in: Vincent JL, editor. Annual Update in Intensive Care and Emergency Medicine 2012. Berlin: Springer; 2012. -, p. 431-441
Zacharowski K, van Aken H, Marx G, Jacob M, Schaffartzik W, Zenz M, Loer SA, Ince C, Martin C, de Hert S, Hollmann MW, Girbes ARJ, Kozek-Langenecker S, Gombotz H, Guidet B, Della Rocca G, Wilson J, de Gasperi A, Comments on Reinhart et al.: consensus statement of the ESICM task force on colloid volume therapy in critically ill patients. INTENS CARE MED 2012;38 (9):1556-1557 [PubMed]
Aksu U, Demirci C, Ince C, The Pathogenesis of Acute Kidney Injury and the Toxic Triangle of Oxygen, Reactive Oxygen Species and Nitric Oxide. CONTRIB NEPHROL 2011;174:119-128 [PubMed]
Atasever B, Boer C, Goedhart P, Biervliet J, Seyffert J, Speekenbrink R, Schwarte L, de Mol B, Ince C, Distinct alterations in sublingual microcirculatory blood flow and hemoglobin oxygenation in on-pump and off-pump coronary artery bypass graft surgery. J CARDIOTHOR VASC AN 2011;25 (5):784-790 [PubMed]
Atasever B, Boer C, Speekenbrink R, Seyffert J, Goedhart P, de Mol B, Ince C, Cardiac displacement during off-pump coronary artery bypass grafting surgery: effect on sublingual microcirculation and cerebral oxygenation. INTERACT CARDIOV TH 2011;13 (6):573-577 [PubMed]
Atasever B, Boer C, van der Kuil M, Lust E, Beishuizen A, Speekenbrink R, Seyffert J, de Mol B, Ince C, Quantitative Imaging of Microcirculatory Response During Nitroglycerin-Induced Hypotension. J CARDIOTHOR VASC AN 2011;25 (1):140-144 [PubMed]
Bartels SA, Bezemer R, de Vries FJW, Milstein DMJ, Lima A, Cherpanath TGV, van den Meiracker AH, van Bommel J, Heger M, Karemaker JM, Ince C, Multi-site and multi-depth near-infrared spectroscopy in a model of simulated (central) hypovolemia: lower body negative pressure. INTENS CARE MED 2011;37 (4):671-677 [PubMed]
Bartels SA, Bezemer R, Milstein DMJ, Radder M, Lima A, Cherpanath TGV, Heger M, Karemaker JM, Ince C, The microcirculatory response to compensated hypovolemia in a lower body negative pressure model. MICROVASC RES 2011;82 (3):374-380 [PubMed]
Bartels SA, Stok WJ, Bezemer R, Boksem RJ, van Goudoever J, Cherpanath TGV, van Lieshout JJ, Westerhof BE, Karemaker JM, Ince C, Noninvasive cardiac output monitoring during exercise testing: Nexfin pulse contour analysis compared to an inert gas rebreathing method and respired gas analysis. J CLIN MONIT COMPUT 2011;25 (5):315-321 [PubMed]
Bezemer R. Optical methods for the assessment of microvascular perfusion and oxygenation. s.l.: s.n.; 2011. 183p. ISBN 9789490371920 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Ince C; copromotor(s): Heger M)
Bezemer R, Dobbe JG, Bartels SA, Christiaan Boerma E, Elbers PWG, Heger M, Ince C, Rapid automatic assessment of microvascular density in sidestream dark field images. MED BIOL ENG COMPUT 2011;49 (11):1269-1278 [PubMed]
Boerma EC, Kaiferová K, Konijn AJM, de Vries JW, Buter H, Ince C, Rectal microcirculatory alterations after elective on-pump cardiac surgery. MINERVA ANESTESIOL 2011;77 (7):698-703 [PubMed]
Dubin A. The relationship of CO2 metabolism to tissue perfusion, microcirculation, and treatment response in shock and sepsis. s.l.: s.n.; 2011. 246p. ISBN 9789490371753 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Ince C; copromotor(s): )
Dyson A, Bezemer R, Legrand M , Balestra G , Singer M, Ince C, Microvascular and interstitial oxygen tension in the renal cortex and medulla studied in a 4-h rat model of LPS-induced endotoxemia. SHOCK 2011;36 (1):83-89 [PubMed]
Edul VSK, Ferrara G, Pozo MO, Murias G, Martins E, Canullén C, Canales HS, Estenssoro E, Ince C, Dubin A, Failure of nitroglycerin (glyceryl trinitrate) to improve villi hypoperfusion in endotoxaemic shock in sheep. CRIT CARE RESUSC 2011;13 (4):252-261 [PubMed]
Elbers PWG, Wijbenga J, Solinger F, Yilmaz A, van Iterson M, van Dongen EPA, Ince C, Direct observation of the human microcirculation during cardiopulmonary bypass: effects of pulsatile perfusion. J CARDIOTHOR VASC AN 2011;25 (2):250-255 [PubMed]
Holloway CJ, Montgomery HE, Murray AJ, Cochlin LE, Codreanu I, Hopwood N, Johnson AW, Rider OJ, Levett DZH, Tyler DJ, Francis JM, Neubauer S, Grocott MPW, Clarke K [Contributors: Grocott M, Montgomery H, Levett D, Martin D, Wilson M, Windsor J, Luery H, Murray A, Stroud M, Khosravi M, Wandrag L, Clarke K, Holloway C, Edwards L, Ince C, Mythen M, Jonas M, Imray C, Newman S, Stygal J, Doyle P, Rodway G, Howard D, McMorrow R, Ahuja V, Aref-Adib G, Burnham RD, Chisholm A, Coates D, Cook D, Dhillon S, Dougall C, Duncan P, Edsell M, Evans L, Gardiner PB, Gunning P, Hart N, Harrington J, Harvey JJ, Hurlbut D, van der Kaaij J, Kolfschoten NN, Luks A, Meale P, Mitchell K, Morgan G, Mythen MM, O'Dwyer MM, Pate JJ, Plant T, Pun M, Richards P, Richardson A, Simpson JJ, Stroud C, Vercueil A, Cox M, Morgan JJ, van Tulleken C, van Tulleken A, Szawarski P]] , Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp. FASEB J 2011;25 (2):792-796 [PubMed]
Johannes T. Experimental strategies in the treatment of acute renal failure in sepsis. s.l.: s.n.; 2011. 112p. ISBN 9789461081377 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Ince C; copromotor(s): )
Kanoore Edul VS, Dubin A, Ince C, The microcirculation as a therapeutic target in the treatment of sepsis and shock. SEMIN RESP CRIT CARE 2011;32 (5):558-568 [PubMed]
Khalilzada M, Dogan K, Ince C, Stam J, Sublingual Microvascular Changes in Patients With Cerebral Small Vessel Disease. STROKE 2011;42 (7):2071-2073 [PubMed]
Legrand M , Bezemer R, Kandil A, Demirci C, Payen D, Ince C, The role of renal hypoperfusion in development of renal microcirculatory dysfunction in endotoxemic rats. INTENS CARE MED 2011;37 (9):1534-1542 [PubMed]
Legrand M , Ince C, Role of sepiapterin on endothelial nitric oxide synthase in acute kidney injury: an enigmatic story. J CARDIOVASC PHARM 2011;58 (3):335-336 [PubMed]
Legrand M , Kandil A, Payen D, Ince C, Effects of sepiapterin infusion on renal oxygenation and early acute renal injury after suprarenal aortic clamping in rats. J CARDIOVASC PHARM 2011;58 (2):192-198 [PubMed]
Levett DZ, Fernandez BO, Riley HL, Martin DS, Mitchell K, Leckstrom CA, Ince C, Whipp BJ, Mythen MG, Montgomery HE, Grocott MP, Feelisch M, The role of nitrogen oxides in human adaptation to hypoxia. SCI REP-UK 2011;1:109 [PubMed]
Lima A, van Bommel J, Sikorska K, van Genderen M, Klijn E, Lesaffre E, Ince C, Bakker J, The relation of near-infrared spectroscopy with changes in peripheral circulation in critically ill patients. CRIT CARE MED 2011;39 (7):1649-1654 [PubMed]
McMorrow RCN, Windsor JS, Mythen MG, Grocott MPW [Contributors: Ahuja V, Aref-Adib G, Burnham R, Chisholm A, Clarke K, Coates D, Coates M, Cook D, Cox M, Dhillon S, Dougall C, Doyle P, Duncan P, Edsell M, Edwards L, Evans L, Gardiner P, Grocott M, Gunning P, Hart N, Harrington J, Harvey J, Holloway C, Howard D, Hurlbut D, Imray C, Ince C, Jonas M, van der Kaaij J, Khosravi M, Kolfschoten N, Levett D, Luery H, Luks A, Martin D, McMorrow R, Meale P, Mitchell K, Montgomery H, Morgan G, Morgan J, Murray A, Mythen M, Newman S, O'Dwyer M, Pate J, Plant T, Pun M, Richards P, Richardson A, Rodway G, Simpson J, Stroud C, Stroud M, Stygal J, Symons B, Szawarski P, van Tulleken A, van Tulleken C, Vercueil A, Wandrag L, Wilson M, Windsor J, Basnyat B, Clarke C, Horn-Bein T, Milledge J, West J]] , A novel ambulatory closed circuit breathing system for use during exercise. ANAESTHESIA 2011;66 (5):348-353 [PubMed]
Mik EG. Measuring microvascular and mitochondrial oxygen tension. Novel techniques for studying tissue oxygeneration. s.l.: s.n.; 2011. 157p. ISBN 9789461081360 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Ince C; copromotor(s): Zuurbier CJ)
Milstein DMJ, Lindeboom JAH, Ince C, The influence of zoledronic acid and cyclophosphamide on microcirculation regeneration in healing oral mucosal flaps. ARCH ORAL BIOL 2011;56 (6):599-606 [PubMed]
Mutalifu Y, Holm L, Ince C, Theodorsson E, Sjöberg F, Multiple different laminar velocity profiles in separate veins in the microvascular network of brain cortex in rats. INT J CLIN EXP MED 2011;4 (1):10-16 [PubMed]
Pérez-Bárcena J, Goedhart P, Ibáñez J, Brell M, García R, Llinás P, Jiménez C, Ince C, Direct observation of human microcirculation during decompressive craniectomy after stroke. CRIT CARE MED 2011;39 (5):1126-1129 [PubMed]
Top APC, Ince C, de Meij N, van Dijk M, Tibboel D, Persistent low microcirculatory vessel density in nonsurvivors of sepsis in pediatric intensive care. CRIT CARE MED 2011;39 (1):8-13 [PubMed]
Top APC, Ince C, Schouwenberg PHM, Tibboel D, Inhaled nitric oxide improves systemic microcirculation in infants with hypoxemic respiratory failure. PEDIATR CRIT CARE ME 2011;12 (6):e271-e274 [PubMed]
Top APC, Tasker RC, Ince C, The microcirculation of the critically ill pediatric patient. CRIT CARE 2011;15 (2):213 [PubMed]
Wilson MH, Edsell MEG, Davagnanam I, Hirani SP, Martin DS, Levett DZH, Thornton JS, Golay X, Strycharczuk L, Newman SP, Montgomery HE, Grocott MPW, Imray CHE [Contributors: Ahuja V, Aref-Adib G, Burnham R, Chisholm A, Clarke K, Coates D, Coates M, Cook D, Cox M, Dhillon S, Dougall C, Doyle P, Duncan P, Edsell M, Edwards L, Evans L, Gardiner P, Grocott M, Gunning P, Hart N, Harrington J, Harvey J, Holloway C, Howard D, Hurlbut D, Imray C, Ince C, Jonas M, van der Kaaij J, Khosravi M, Kolfschoten N, Levett D, Luery H, Luks A, Martin D, McMorrow R, Meale P, Mitchell K, Montgomery H, Morgan G, Morgan J, Murray A, Mythen M, Newman S, O'Dwyer M, Pate J, Plant T, Pun M, Richards P, Richardson A, Rodway G, Simpson J, Stroud C, Stroud M, Stygal J, Symons B, Szawarski P, van Tulleken A, van Tulleken C, Vercueil A, Wandrag L, Wilson M, Windsor J, Basnyat B, Clarke C, Hornbein T, Milledge J, West J]] , Cerebral artery dilatation maintains cerebral oxygenation at extreme altitude and in acute hypoxia--an ultrasound and MRI study. J CEREBR BLOOD F MET 2011;31 (10):2019-2029 [PubMed]
Yuruk K, Almac E, Bezemer R, Goedhart P, de Mol B, Ince C, Blood transfusions recruit the microcirculation during cardiac surgery. TRANSFUSION 2011;51 (5):961-967 [PubMed]
Balestra GM, Bezemer R, Boerma EC, Yong ZY, Sjauw KD, Engstrom AE, Koopmans M, Ince C, Improvement of Sidestream Dark Field Imaging with an Image Acquisition Stabilizer. BMC MED IMAGING 2010;10 (1):15 [PubMed]
Bezemer R, Faber DJ, Almac E, Kalkman J, Legrand M , Heger M, Ince C, Evaluation of multi-exponential curve fitting analysis of oxygen-quenched phosphorescence decay traces for recovering microvascular oxygen tension histograms. MED BIOL ENG COMPUT 2010;48 (12):1233-1242 [PubMed]
Bezemer R, Klijn E, Khalilzada M, Lima A, Heger M, van Bommel J, Ince C, Validation of near-infrared laser speckle imaging for assessing microvascular (re)perfusion. MICROVASC RES 2010;79 (2):139-143 [PubMed]
Bezemer R, Legrand M , Klijn E, Heger M, Post ICJH, van Gulik TM, Payen D, Ince C, Real-time assessment of renal cortical microvascular perfusion heterogeneities using near-infrared laser speckle imaging. OPT EXPRESS 2010;18 (14):15054-15061 [PubMed]
Boerma EC, Ince C, Can normal be more normal than normal?. CRIT CARE MED 2010;38 (2):738 [PubMed]
Boerma EC, Ince C, The role of vasoactive agents in the resuscitation of microvascular perfusion and tissue oxygenation in critically ill patients. INTENS CARE MED 2010;36 (12):2004-2018 [PubMed]
Boerma EC, Koopmans M, Konijn A, Kaiferova K, Bakker AJ, van Roon EN, Buter H, Bruins N, Egbers PH, Gerritsen RT, Koetsier PM, Kingma WP, Kuiper MA, Ince C, Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: A double-blind randomized placebo controlled trial. CRIT CARE MED 2010;38 (1):93-100 [PubMed]
Boldt J, Ince C, The impact of fluid therapy on microcirculation and tissue oxygenation in hypovolemic patients: a review. INTENS CARE MED 2010;36 (8):1299-1308 [PubMed]
Dubin A, Pozo MO, Casabella CA, Murias G, Palizas F Jr., Moseinco MC, Kanoore EVS, Palizas F, Estenssoro E, Ince C, Comparison of 6% hydroxyethyl starch 130/0.4 and saline solution for resuscitation of the microcirculation during the early goal-directed therapy of septic patients. J CRIT CARE 2010;25 (4):659-659.e8 [PubMed]
Edwards LM, Murray AJ, Tyler DJ, Kemp GJ, Holloway CJ, Robbins PA, Neubauer S, Levett D, Montgomery HE, Grocott MP, Clarke K [Contributors: Ahuja V, Aref-Adib G, Burnham R, Chisholm A, Clarke K, Coates D, Coates M, Cook D, Cox M, Dhillon S, Dougall C, Doyle P, Duncan P, Edsell M, Edwards L, Evans L, Gardiner P, Grocott M, Gunning P, Hart N, Harrington J, Harvey J, Holloway C, Howard D, Hurlbut D, Imray C, Ince C, Jonas M, van der Kaaij J, Khosravi M, Kolfschoten N, Levett D, Luery H, Luks A, Martin D, McMorrow R, Meale P, Mitchell K, Montgomery H, Morgan G, Morgan J, Murray A, Mythen M, Newman S, O'Dwyer M, Pate J, Plant T, Pun M, Richards P, Richardson A, Rodway G, Simpson J, Stroud C, Stroud M, Stygal J, Symons B, Szawarski P, van Tulleken A, van Tulleken C, Vercueil A, Wandrag L, Wilson M, Windsor J, Basnyat B, Clarke C, Hornbein T, Milledge J, West J]] , The effect of high-altitude on human skeletal muscle energetics: P-MRS results from the Caudwell Xtreme Everest expedition. PLOS ONE 2010;5 (5):e10681 [PubMed]
Elbers PWG. Focus on flow. Imaging the human microcirculation in perioperative and intensive care medicine. s.l.: s.n.; 2010. 154p. ISBN 9789490371388 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Ince C; copromotor(s): van Dongen HPA)
Elbers PWG, Craenen AJ, Driessen A, Stehouwer MC, Munsterman L, Prins M, van Iterson M, Bruins P, Ince C, Imaging the human microcirculation during cardiopulmonary resuscitation in a hypothermic victim of submersion trauma. RESUSCITATION 2010;81 (1):123-125 [PubMed]
Elbers PWG, Ozdemir A, Heijmen RH, Heeren J, van Iterson M, van Dongen EPA, Ince C, Microvascular hemodynamics in human hypothermic circulatory arrest and selective antegrade cerebral perfusion. CRIT CARE MED 2010;38 (7):1548-1553 [PubMed]
Grocott MPW, Martin DS, Wilson MH, Mitchell K, Dhillon S, Mythen MG, Montgomery HE, Levett DZH [Contributors: Ahuja V, Aref-Adib G, Burnham R, Chisholm A, Clarke K, Coates D, Coates M, Cook D, Cox M, Dhillon S, Dougall C, Doyle P, Duncan P, Edsell M, Edwards L, Evans L, Gardiner P, Grocott M, Gunning P, Hart N, Harrington J, Harvey J, Holloway C, Howard D, Hurlbut D, Imray C, Ince C, Jonas M, van der Kaaij J, Khosravi M, Kolfschoten N, Levett D, Luery H, Luks A, Martin D, McMorrow R, Meale P, Mitchell K, Montgomery H, Morgan G, Morgan J, Murray A, Mythen M, Newman S, O'Dwyer M, Pate J, Plant T, Pun M, Richards P, Richardson A, Rodway G, Simpson J, Stroud C, Stroud M, Stygal J, Symons B, Szawarski P, van Tulleken A, van Tulleken C, Vercueil A, Wandrag L, Wilson M, Windsor J]] , Caudwell xtreme everest expedition. HIGH ALT MED BIOL 2010;11 (2):133-137 [PubMed]
Klijn E, Niehof S, de Jonge J, Gommers D, Ince C, van Bommel J, The effect of perfusion pressure on gastric tissue blood flow in an experimental gastric tube model. ANESTH ANALG 2010;110 (2):541-546 [PubMed]
Legrand M , Klijn E, Payen D, Ince C, The response of the host microcirculation to bacterial sepsis: does the pathogen matter?. J MOL MED-JMM 2010;88 (2):127-133 [PubMed]
Legrand M , Mik EG, Balestra GM, Lutter R, Pirracchio R, Payen D, Ince C, Fluid Resuscitation Does Not Improve Renal Oxygenation during Hemorrhagic Shock in Rats. ANESTHESIOLOGY 2010;112 (1):119-127 [PubMed]
Levett DZH, Martin DS, Wilson MH, Mitchell K, Dhillon S, Rigat F, Montgomery HE, Mythen MG, Grocott MPW [Contributors: Ahuja V, Aref-Adib G, Burnham R, Chisholm A, Clarke K, Coates D, Coates M, Cook D, Cox M, Dhillon S, Dougall C, Doyle P, Duncan P, Edsell M, Edwards L, Evans L, Gardiner P, Grocott M, Gunning P, Hart N, Harrington J, Harvey J, Holloway C, Howard D, Hurlbut D, Imray C, Ince C, Jonas M, van der Kaaij J, Khosravi M, Kolfschoten N, Levett D, Luery H, Luks A, Martin D, McMorrow R, Meale P, Mitchell K, Montgomery H, Morgan G, Morgan J, Murray A, Mythen M, Newman S, O'Dwyer M, Pate J, Plant T, Pun M, Richards P, Richardson A, Rodway G, Simpson J, Stroud C, Stroud M, Stygal J, Symons B, Szawarski P, van Tulleken A, van Tulleken C, Vercueil A, Wandrag L, Wilson M, Windsor J, Basnyat B, Clarke C, Hornbein T, Milledge J, West J]] , Design and conduct of Caudwell Xtreme Everest: an observational cohort study of variation in human adaptation to progressive environmental hypoxia. BMC MED RES METHODOL 2010;10:98 [PubMed]
Martin DS, Goedhart P, Vercueil A, Ince C, Levett DZH, Grocott MPW, Changes in sublingual microcirculatory flow index and vessel density on ascent to altitude. EXP PHYSIOL 2010;95 (8):880-891 [PubMed]
Milstein DMJ. The response of the oral microcirculation to pharmacological and surgical interventions. s.l.: s.n.; 2010. 145p. ISBN 9789490371449 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam, onderzoek bij UvA, ACTA. (Promotor(s): Ince C, van den Akker HP; copromotor(s): Lindeboom JAH)
Milstein DMJ, Lindeboom JAH, Ince C, Intravital sidestream dark-field (SDF) imaging is used in a rabbit model for continuous noninvasive monitoring and quantification of mucosal capillary regeneration during wound healing in the oral cavity: A pilot study. ARCH ORAL BIOL 2010;55 (5):343-349 [PubMed]
Milstein DMJ, te Boome LCJ, Cheung YW, Lindeboom JAH, van den Akker HP, Biemond BJ, Ince C, Use of sidestream dark-field (SDF) imaging for assessing the effects of high-dose melphalan and autologous stem cell transplantation on oral mucosal microcirculation in myeloma patients. ORAL SURG ORAL MED O 2010;109 (1):91-97 [PubMed]
Morelli A, Donati A, Ertmer C, Rehberg S, Lange M, Orecchioni A, Cecchini V, Landoni G, Pelaia P, Pietropaoli P, van Aken H, Teboul JL, Ince C, Westphal M, Levosimendan for resuscitating the microcirculation in patients with septic shock: a randomized controlled study. CRIT CARE 2010;14 (6):R232 [PubMed]
Munsterman LDH, Elbers PWG, Ozdemir A, van Dongen EPA, van Iterson M, Ince C, Withdrawing intra-aortic balloon pump support paradoxically improves microvascular flow. CRIT CARE 2010;14 (4):R161 [PubMed]
Mutsaerts HJMM, Out M, Goedhart PT, Ince C, Hardeman MR, Romijn JA, Rabelink TJ, Reiber JHC, Box FMA, Improved viscosity modeling in patients with type 2 diabetes mellitus by accounting for enhanced red blood cell aggregation tendency. CLIN HEMORHEOL MICRO 2010;44 (4):302-313 [PubMed]
Siegemund M, van Bommel J, Stegenga ME, Studer W, van Iterson M, Annaheim S, Mebazaa A, Ince C, Aortic Cross-Clamping and Reperfusion in Pigs Reduces Microvascular Oxygenation by Altered Systemic and Regional Blood Flow Distribution. ANESTH ANALG 2010;111 (2):345-353 [PubMed]
Smeele KM, Eerbeek O , Koeman A, Bezemer R, Ince C, Heikkinen S, Laakso M, de Haan A, Schaart G, Drost MR, Hollmann MW, Zuurbier CJ, Partial hexokinase II knockout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice. PFLUG ARCH EUR J PHY 2010;459 (5):705-712 [PubMed]
Top APC, van Dijk M, van Velzen JE, Ince C, Tibboel D, Functional Capillary Density Decreases after the First Week of Life in Term Neonates. NEONATOLOGY 2010;99 (1):73-77 [PubMed]
Vellinga NAR, Ince C, Boerma EC, Microvascular dysfunction in the surgical patient. CURR OPIN CRIT CARE 2010;16 (4):377-383 [PubMed]
Yapici N, Ince C, Gastrointestinal complications and its predictors after cardiac surgery. TURK J GASTROENTEROL 2010;21 (1):3-6 [PubMed]
Balestra GM, Legrand M , Ince C, Microcirculation and mitochondria in sepsis: getting out of breath. CURR OPIN ANESTHESIO 2009;22 (2):184-190 [PubMed]
Bemelmans RHH, Boerma EC, Barendregt J, Ince C, Rommes JH, Spronk PE, Changes in the volume status of haemodialysis patients are reflected in sublingual microvascular perfusion. NEPHROL DIAL TRANSPL 2009;24 (11):3487-3492 [PubMed]
Bezemer R, Karemaker JM, Klijn E, Martin D, Mitchell K, Grocott M, Heger M, Ince C, Simultaneous multi-depth assessment of tissue oxygen saturation in thenar and forearm using near-infrared spectroscopy during a simple cardiovascular challenge. CRIT CARE 2009;13 (Suppl. 5):S5 [PubMed]
Bezemer R, Lima A, Myers D, Klijn E, Heger M, Goedhart PT, Bakker J, Ince C, Assessment of tissue oxygen saturation during a vascular occlusion test using near-infrared spectroscopy: the role of probe spacing and measurement site studied in healthy volunteers. CRIT CARE 2009;13 (Suppl. 5):S4 [PubMed]
Boerma EC. Distributive failure in the microcirculation of septic patients. s.l.: s.n.; 2009. 142p. ISBN 9789490122157 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Ince C; copromotor(s): van der Voort PHJ, Kuiper MA)
den Uil CA, Bezemer R, Miranda DR, Ince C, Lagrand WK, Hartman M, Bogers AJ, Spronk PE, Simoons ML, Intra-operative assessment of human pulmonary alveoli in vivo using Sidestream Dark Field imaging: a feasibility study. MED SCI MONITOR 2009;15 (10):MT137-MT141 [PubMed]
den Uil CA, Lagrand WK, Spronk PE, van der Ent M, Jewbali LSD, Brugts JJ, Ince C, Simoons ML, Low-dose nitroglycerin improves microcirculation in hospitalized patients with acute heart failure. EUR J HEART FAIL 2009;11 (4):386-390 [PubMed]
Donati A, Romanelli M, Botticelli L, Valentini A, Gabbanelli V, Nataloni S, Principi T, Pelaia P, Bezemer R, Ince C, Recombinant activated protein C treatment improves tissue perfusion and oxygenation in septic patients measured by near-infrared spectroscopy. CRIT CARE 2009;13 (Suppl. 5):S12 [PubMed]
Dubin A, Pozo MO, Casabella CA, Palizas F Jr, Murias G, Moseinco MC, Kanoore Edul VS, Palizas F, Estenssoro E, Ince C, Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study. CRIT CARE 2009;13 (3):R92 [PubMed]
Dubin A, Pozo MO, Ferrara G, Murias G, Martins E, Canullán C, Canales HS, Kanoore Edul VS, Estenssoro E, Ince C, Systemic and microcirculatory responses to progressive hemorrhage. INTENS CARE MED 2009;35 (3):556-564 [PubMed]
Elbers PWG, Ozdemir A, van Iterson M, van Dongen EPA, Ince C, Microcirculatory Imaging in Cardiac Anesthesia: Ketanserin Reduces Blood Pressure But Not Perfused Capillary Density. J CARDIOTHOR VASC AN 2009;23 (1):95-101 [PubMed]
Gómez H, Mesquida J, Simon P, Kim HK, Puyana JC, Ince C, Pinsky MR, Characterization of tissue oxygen saturation and the vascular occlusion test: influence of measurement sites, probe sizes and deflation thresholds. CRIT CARE 2009;13 (Suppl. 5):S3 [PubMed]
Grocott MPW, Martin DS, Levett DZH, McMorrow R, Windsor J, Montgomery HE [Contributors: Ahuja V, Aref-Adib G, Burnham R, Chisholm A, Clarke K, Coates D, Coates M, Cook D, Cox M, Dhillon S, Dougall C, Doyle P, Duncan P, Edsell M, Edwards L, Evans L, Gardiner P, Grocott M, Gunning P, Hart N, Harrington J, Harvey J, Holloway C, Howard D, Hurlbut D, Imray C, Ince C, Jonas M, van der Kaaij J, Khosravi M, Kolfschoten N, Levett D, Luery H, Luks A, Martin D, McMorrow R, Meale P, Mitchell K, Montgomery H, Morgan G, Morgan J, Murray A, Mythen M, Newman S, O'Dwyer M, Pate J, Plant T, Pun M, Richards P, Richardson A, Rodway G, Simpson J, Stroud C, Stroud M, Stygal J, Symons B, Szawarski P, van Tulleken A, van Tulleken C, Vercueil A, Wandrag L, Wilson M, Windsor J, Basnyat B, Clarke C, Hornbein T, Milledge J, West J]] , Arterial blood gases and oxygen content in climbers on Mount Everest. NEW ENGL J MED 2009;360 (2):140-149 [PubMed]
Ince C, Bezemer R, Lima A, Near infrared spectroscopy. CRIT CARE MED 2009;37 (1):384-385 [PubMed]
Johannes T, Ince C, Klingel K, Unertl KE, Mik EG, Iloprost preserves renal oxygenation and restores kidney function in endotoxemia-related acute renal failure in the rat. CRIT CARE MED 2009;37 (4):1423-1432 [PubMed]
Johannes T, Mik EG, Ince C, Nonresuscitated endotoxemia induces microcirculatory hypoxic areas in the renal cortex in the rat. SHOCK 2009;31 (1):97-103 [PubMed]
Johannes T, Mik EG, Klingel K, Dieterich HJ, Unertl KE, Ince C, Low-dose dexamethasone-supplemented fluid resuscitation reverses endotoxin-induced acute renal failure and prevents cortical microvascular hypoxia. SHOCK 2009;31 (5):521-528 [PubMed]
Johannes T, Mik EG, Klingel K, Goedhart PT, Zanke C, Nohé B, Dieterich HJ, Unertl KE, Ince C, Effects of 1400W and/or nitroglycerin on renal oxygenation and kidney function during endotoxaemia in anaesthetized rats. CLIN EXP PHARMACOL P 2009;36 (9):870-879 [PubMed]
Lam K, Sjauw KD, Henriques JPS, Ince C, de Mol BAJM, Improved microcirculation in patients with an acute ST-elevation myocardial infarction treated with the Impella LP2.5 percutaneous left ventricular assist device. CLIN RES CARDIOL 2009;98 (5):311-318 [PubMed]
Le Dorze M, Legrand M , Payen D, Ince C, The role of the microcirculation in acute kidney injury. CURR OPIN CRIT CARE 2009;15 (6):503-508 [PubMed]
Legrand M , Almac E, Mik EG, Johannes T, Kandil A, Bezemer R, Payen D, Ince C, L-NIL prevents renal microvascular hypoxia and increase of renal oxygen consumption after ischemia-reperfusion in rats. AM J PHYSIOL-RENAL 2009;296 (5):F1109-F1117 [PubMed]
Lima A, Jansen TC, van Bommel J, Ince C, Bakker J, The prognostic value of the subjective assessment of peripheral perfusion in critically ill patients. CRIT CARE MED 2009;37 (3):934-938 [PubMed]
Lima A, van Bommel J, Jansen TC, Ince C, Bakker J, Low tissue oxygen saturation at the end of early goal-directed therapy is associated with worse outcome in critically ill patients. CRIT CARE 2009;13 (Suppl. 5):S13 [PubMed]
Martin DS, Ince C, Goedhart P, Levett DZH, Grocott MPW, Abnormal blood flow in the sublingual microcirculation at high altitude. EUR J APPL PHYSIOL 2009;106 (3):473-478 [PubMed]
Mik EG, Ince C, Eerbeek O , Heinen A, Stap J, Hooibrink B, Schumacher CA, Balestra GM, Johannes T, Beek JF, Nieuwenhuis AF, van Horssen P, Spaan JA, Zuurbier CJ, Mitochondrial oxygen tension within the heart. J MOL CELL CARDIOL 2009;46 (6):943-951 [PubMed]
Milstein DMJ, Bezemer R, Lindeboom JAH, Ince C, The acute effects of CMF-based chemotherapy on maxillary periodontal microcirculation. CANCER CHEMOTH PHARM 2009;64 (5):1047-1052 [PubMed]
Milstein DMJ, Mathura KR, Lindeboom JAH, Ramsoekh D, Lindeboom R, Ince C, The temporal course of mucoperiosteal flap revascularization at guided bone regeneration-treated implant sites: a pilot study. J CLIN PERIODONTOL 2009;36 (10):892-897 [PubMed]
Nieuwdorp M, Meuwese MC, Mooij HL, van Lieshout MHP, Hayden A, Levi M, Meijers JCM, Ince C, Kastelein JJP, Vink H, Stroes ESG, Tumor necrosis factor-alpha inhibition protects against endotoxin-induced endothelial glycocalyx perturbation. ATHEROSCLEROSIS 2009;202 (1):296-303 [PubMed]
Raat NJH, Hilarius PM, Johannes T, de Korte D, Ince C, Verhoeven AJ, Rejuvenation of stored human red blood cells reverses the renal microvascular oxygenation deficit in an isovolemic transfusion model in rats. TRANSFUSION 2009;49 (3):427-434 [PubMed]
Top APC, Ince C, van Dijk M, Tibboel D, Changes in buccal microcirculation following extracorporeal membrane oxygenation in term neonates with severe respiratory failure. CRIT CARE MED 2009;37 (3):1121-1124 [PubMed]
Boerma EC, Kuiper M, Kingma WP, Egbers PH, Gerritsen RT, Ince C, Disparity between skin perfusion and sublingual microcirculatory alterations in severe sepsis and septic shock: a prospective observational study. INTENS CARE MED 2008;34 (7):1294-1298 [PubMed]
den Uil CA, Klijn E, Lagrand WK, Brugts JJ, Ince C, Spronk PE, Simoons ML, The microcirculation in health and critical disease. PROG CARDIOVASC DIS 2008;51 (2):161-170 [PubMed]
Dobbe JGG, Streekstra GJ, Atasever B, van Zijderveld R, Ince C, Measurement of functional microcirculatory geometry and velocity distributions using automated image analysis. MED BIOL ENG COMPUT 2008;46 (7):659-670 [PubMed]
Dondorp AM, Ince C, Charunwatthana P, Hanson J, van Kuijen A, Faiz MA, Rahman MR, Hasan M, Bin Yunus E, Ghose A, Ruangveerayut R, Limmathurotsakul D, Mathura K, White NJ, Day NPJ, Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria. J INFECT DIS 2008;197 (1):79-84 [PubMed]
Dubin A, Edul VSK, Pozo MO, Murias G, Canullán CM, Martins EF, Ferrara G, Canales HS, Laporte M, Estenssoro E, Ince C, Persistent villi hypoperfusion explains intramucosal acidosis in sheep endotoxemia. CRIT CARE MED 2008;36 (2):535-542 [PubMed]
Fries M, Ince C, Rossaint R, Bleilevens C, Bickenbach J, Rex S, Mik EG, Levosimendan but not norepinephrine improves microvascular oxygenation during experimental septic shock. CRIT CARE MED 2008;36 (6):1886-1891 [PubMed]
Ince C, The elusive microcirculation. INTENS CARE MED 2008;34 (10):1755-1756 [PubMed]
Klijn E, den Uil CA, Bakker J, Ince C, The heterogeneity of the microcirculation in critical illness. CLIN CHEST MED 2008;29 (4):643-654 [PubMed]
Legrand M , Mik EG, Johannes T, Payen D, Ince C, Renal hypoxia and dysoxia after reperfusion of the ischemic kidney. MOL MED 2008;14 (7-8):502-516 [PubMed]
Lindeboom JA, Mathura KR, Milstein DMJ, Ince C, Microvascular soft tissue changes in alveolar distraction osteogenesis. ORAL SURG ORAL MED O 2008;106 (3):350-355 [PubMed]
Mik EG, Johannes T, Ince C, Monitoring of renal venous PO2 and kidney oxygen consumption in rats by a near-infrared phosphorescence lifetime technique. AM J PHYSIOL-RENAL 2008;294 (3):F676-F681 [PubMed]
Mik EG, Johannes T, Zuurbier CJ, Heinen A, Houben-Weerts JHPM, Balestra GM, Stap J, Beek JF, Ince C, In vivo mitochondrial oxygen tension measured by a delayed fluorescence lifetime technique. BIOPHYS J 2008;95 (8):3977-3990 [PubMed]
Nieuwdorp M, Meuwese MC, Mooij HL, Ince C, Broekhuizen LN, Kastelein JJP, Stroes ESG, Vink H, Measuring endothelial glycocalyx dimensions in humans: a potential novel tool to monitor vascular vulnerability. J APPL PHYSIOL 2008;104 (3):845-852 [PubMed]
van Beers EJ, Goedhart PT, Unger M, Biemond BJ, Ince C, Normal sublingual microcirculation during painful crisis in sickle cell disease. MICROVASC RES 2008;76 (1):57-60 [PubMed]
van Bommel J, Siegemund M, Henny CP, Ince C, Heart, kidney, and intestine have different tolerances for anemia. TRANSL RES 2008;151 (2):110-117 [PubMed]
Almac E, Ince C, The impact of storage on red cell function in blood transfusion. BEST PRACT RES CLIN ANAESTHESIOL 2007;21 (2):195-208 [PubMed]
Boerma EC, van der Voort PHJ, Spronk PE, Ince C, Relationship between sublingual and intestinal microcirculatory perfusion in patients with abdominal sepsis. CRIT CARE MED 2007;35 (4):1055-1060 [PubMed]
de Backer D, Hollenberg S, Boerma C, Goedhart P, Büchele G, Ospina-Tascon G, Dobbe I, Ince C, How to evaluate the microcirculation: report of a round table conference. CRIT CARE 2007;11 (5):R101-9 [PubMed]
Erol-Yilmaz A, Atasever B, Mathura K, Lindeboom J, Wilde A, Ince C, Tukkie R, Cardiac resynchronization improves microcirculation. J CARD FAIL 2007;13 (2):95-99 [PubMed]
Goedhart PT, Khalilzada M, Bezemer R, Merza J, Ince C, Sidestream Dark Field (SDF) imaging: a novel stroboscopic LED ring-based imaging modality for clinical assessment of the microcirculation. OPT EXPRESS 2007;15 (23):15101-15114 [PubMed]
Jansen GFA, Krins A, Basnyat B, Odoom JA, Ince C, Role of the altitude level on cerebral autoregulation in residents at high altitude. J APPL PHYSIOL 2007;103 (2):518-523 [PubMed]
Johannes T, Mik EG, Nohé B, Unertl KE, Ince C, Acute decrease in renal microvascular PO2 during acute normovolemic hemodilution. AM J PHYSIOL-RENAL 2007;292 (2):F796-F803 [PubMed]
Lindeboom JAH, Mathura KR, Aartman IHA, Kroon FHM, Milstein DMJ, Ince C, Influence of the application of platelet-enriched plasma in oral mucosal wound healing. CLIN ORAL IMPLAN RES 2007;18 (1):133-139 [PubMed]
Pennings FA. The clinical value of assessing cerebral ischemia : emphasis on brain tissue oxygenation and function of the cerebral microcirculation. s.l.: s.n.; 2007. 112p. ISBN 9789051709322 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Bosch DA, Ince C; copromotor(s): Bouma GJ)
Raat NJH, Ince C, Oxygenating the microcirculation: the perspective from blood transfusion and blood storage. VOX SANG 2007;93 (1):12-18 [PubMed]
Siegemund M, van Bommel J, Sinaasappel M, Schwarte LA, Studer W, Girard T, Vollebregt K, Ince C, The NO donor SIN-1 improves intestinal-arterial P(CO(2)) gap in experimental endotoxemia: an animal study. ACTA ANAESTH SCAND 2007;51 (6):693-700 [PubMed]
Spoelstra EN, Ince C, Koeman A, Emons VM, Brouwer LA, van Luyn MJA, Westerink BHC, Remie R, A novel and simple method for endotracheal intubation of mice. LAB ANIM-UK 2007;41 (1):128-135 [PubMed]
Almac E, Siegemund M, Demirci C, Ince C, Microcirculatory recruitment maneuvers correct tissue CO2 abnormalities in sepsis. MINERVA ANESTESIOL 2006;72 (6):507-519 [PubMed]
Elbers PWG, Ince C, Mechanisms of critical illness--classifying microcirculatory flow abnormalities in distributive shock. CRIT CARE 2006;10 (4):221 [PubMed]
Ince C, Go with the flow--recruit the microcirculation!. INTENS CARE MED 2006;32 (4):488-489 [PubMed]
Johannes T, Mik EG, Ince C, Dual-wavelength phosphorimetry for determination of cortical and subcortical microvascular oxygenation in rat kidney. J APPL PHYSIOL 2006;100 (4):1301-1310 [PubMed]
Johannes T, Mik EG, Nohé B, Raat NJH, Unertl KE, Ince C, Influence of fluid resuscitation on renal microvascular PO2 in a normotensive rat model of endotoxemia. CRIT CARE 2006;10 (3):R88 [PubMed]
Lindeboom JA, Mathura KR, Ince C, Orthogonal polarization spectral (OPS) imaging and topographical characteristics of oral squamous cell carcinoma. ORAL ONCOL 2006;42 (6):581-585 [PubMed]
Lindeboom JA, Mathura KR, Ramsoekh D, Harkisoen S, Aartman IH, van den Akker HP, Ince C, The assessment of the gingival capillary density with orthogonal spectral polarization (OPS) imaging. ARCH ORAL BIOL 2006;51 (8):697-702 [PubMed]
Mik EG, Stap J, Sinaasappel M, Beek JF, Aten JA, van Leeuwen TG, Ince C, Mitochondrial PO2 measured by delayed fluorescence of endogenous protoporphyrin IX. NAT METHODS 2006;3 (11):939-945 [PubMed]
Nieuwdorp M, Mooij HL, Kroon J, Atasever B, Spaan JAE, Ince C, Holleman F, Diamant M, Heine RJ, Hoekstra JBL, Kastelein JJP, Stroes ESG, Vink H, Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes. DIABETES 2006;55 (4):1127-1132 [PubMed]
Pennings FA, Ince C, Bouma GJ, Continuous real-time visualization of the human cerebral microcirculation during arteriovenous malformation surgery using orthogonal polarization spectral imaging. NEUROSURGERY 2006;59 (1):167-71; discussion 167-71 [PubMed]
Spronk PE, Rommes JH, Schaar C, Ince C, Thrombolysis in fulminant purpura: observations on changes in microcirculatory perfusion during successful treatment. THROMB HAEMOSTASIS 2006;95 (3):576-578 [PubMed]
van den Oever HLA, Dzoljic M, Ince C, Hollmann MW, Mokken FC, Orthogonal polarization spectral imaging of the microcirculation during acute hypervolemic hemodilution and epidural lidocaine injection. ANESTH ANALG 2006;103 (2):484-7, table of contents [PubMed]
Boerma EC, Mathura KR, van der Voort PHJ, Spronk PE, Ince C, Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients: a prospective validation study. CRIT CARE MED 2005;9 (6):R601-R606 [PubMed]
Boerma EC, van der Voort PHJ, Ince C, Sublingual microcirculatory flow is impaired by the vasopressin-analogue terlipressin in a patient with catecholamine-resistant septic shock. ACTA ANAESTH SCAND 2005;49 (9):1387-1390 [PubMed]
Buise MP, Ince C, Tilanus HW, Klein J, Gommers D, van Bommel J, The effect of nitroglycerin on microvascular perfusion and oxygenation during gastric tube reconstruction. ANESTH ANALG 2005;100 (4):1107-1111 [PubMed]
Heger M, Beek J, Stenback K, Faber D, van Gemert M, Ince C, Darkfield orthogonal polarized spectral imaging for studying endovascular laser-tissue interactions in vivo - a preliminary study. OPT EXPRESS 2005;13 (3):702-715 [PubMed]
Ince C. Microcirculatory distress in critically ill patients: meaning and future in: Fink MP, Suter PM, Sibbald WJ, editors. Update in intensive care and emergency medicine: intensive care medicine in 10 years. S.l.: Springer Verlag; 2005., p. 165-177
Ince C, The microcirculation is the motor of sepsis. CRIT CARE 2005;9 (Suppl. 4):S13-S19 [PubMed]
Lindeboom JAH, Mathura KR, Ince C. The microcirculation during wound healing after oral and maxillofacial surgical procedures in: Vincent JL, editor. Yearbook of intensive care and emergency medicine 2005. S.l.: Springer Verlag; 2005., p. 519-527
Lindeboom JA, Mathura KR, Harkisoen S, van den Akker HP, Ince C, Effect of smoking on the gingival capillary density: assessment of gingival capillary density with orthogonal polarization spectral imaging. J CLIN PERIODONTOL 2005;32 (12):1208-1212 [PubMed]
Milstein DMJ, Lindeboom JAH, Ince C. Sidestream dark-field imaging and image analysis of oral microcirculation under clinical conditions in: Gullo A, editor. Anaesthesia pain IC and emergency. S.l.: s.n.; 2005., p. 79-88
Raat NJH, Berends F, Verhoeven AJ, de Korte D, Ince C, The age of stored red blood cell concentrates at the time of transfusion. TRANSFUSION MED 2005;15 (5):419-423 [PubMed]
Raat NJH, Liu JF, Doyle MP, Burhop KE, Klein J, Ince C, Effects of recombinant-hemoglobin solutions rHb2.0 and rHb1.1 on blood pressure, intestinal blood flow, and gut oxygenation in a rat model of hemorrhagic shock. J LAB CLIN MED 2005;145 (1):21-32 [PubMed]
Raat NJ, Verhoeven AJ, Mik EG, Gouwerok CW, Verhaar R, Goedhart PT, de Korte D, Ince C, The effect of storage time of human red cells on intestinal microcirculatory oxygenation in a rat isovolemic exchange model. CRIT CARE MED 2005;33 (1):39-45 [PubMed]
Schwarte LA, Fournell A, van Bommel J, Ince C, Redistribution of intestinal microcirculatory oxygenation during acute hemodilution in pigs. J APPL PHYSIOL 2005;98 (3):1070-1075 [PubMed]
Siegemund M, van Bommel J, Schwarte LA, Studer W, Girard T, Marsch S, Radermacher P, Ince C, Inducible nitric oxide synthase inhibition improves intestinal microcirculatory oxygenation and CO2 balance during endotoxemia in pigs. INTENS CARE MED 2005;31 (7):985-992 [PubMed]
Spronk PE, Kanoore-Edul VS, Ince C. Microcirculatory and mitochondrial distress syndrome (MMDS): a new look at sepsis in: Pinsky MR, Payen D, editors. Functional hemodynamic monitoring. Update in intensive care and emergency medicine. S.l.: Sringer; 2005.
Zuurbier CJ, Demirci C, Koeman A, Vink H, Ince C, Short-term hyperglycemia increases endothelial glycocalyx permeability and acutely decreases lineal density of capillaries with flowing red blood cells. J APPL PHYSIOL 2005;99 (4):1471-1476 [PubMed]
de Mik E, Ince C. Optical spectroscopy in mice in: Ince C, editor. The physiological genomics of the critically ill mouse. Boston: Kluwer Academic Publishers; 2004., p. 73-89
Eerbeek O , Mik EG, Zuurbier CJ, van 't Loo M, Donkersloot C, Ince C, Ratiometric intracellular calcium imaging in the isolated beating rat heart using indo-1 fluorescence. J APPL PHYSIOL 2004;97 (6):2042-2050 [PubMed]
Ince C, editor, Basic science for the cardiologist. Norwell, Dordrecht: Kluwer Academic Publishers; 2004. -p.
Ince C, Microcirculation in distress: A new resuscitation end point?. CRIT CARE MED 2004;32 (9):1963-1964 [PubMed]
Ince C, editor, The physiological genomics of the critically ill mouse. Boston: Kluwer Academic Publishers; 2004. -p. ISBN 1-4020-7641-x
Ince C, editor, The physiological genomics of the critically ill mouse. Boston: Kluwer Academic Publishers; 2004. 385p. ISBN 1-4020-7641-x
Mik EG, van Leeuwen TG, Raat NJ, Ince C, Quantitative determination of localized tissue oxygen concentration in vivo by two-photon excitation phosphorescence lifetime measurements. J APPL PHYSIOL 2004;97 (5):1962-1969 [PubMed]
Pennings FA, Bouma GJ, Ince C, Direct observation of the human cerebral microcirculation during aneurysm surgery reveals increased arteriolar contractility. STROKE 2004;35 (6):1284-1288 [PubMed]
Schwarte LA, Ince C. Mechanical ventilation in mice in: Ince C, editor. The physiological genomics of the critically ill mouse. Boston: Kluwer Academic Publishers; 2004., p. 35-53
Spronk PE, Zandstra DF, Ince C, Bench-to-bedside review: Sepsis is a disease of the microcirculation. CRIT CARE 2004;8 (6):462-468 [PubMed]
Spronk PE, Zandstra DF, Ince C, Norepinephrine compromises intestinal microvascular perfusion?. INTENS CARE MED 2004;30 (1):173-174 [PubMed]
van Iterson M, Ince C. Resuscitation of the microcirculation with hemoglobin-based oxygen carriers following hemorrhage in: Vincent JL, editor. Yearbook of intensive care and emergency medicine 2004. Berlin: Springer-Verlag; 2004., p. 762-779
van Zanten AR, Schultz MJ, van der Voort PH, Kuiper MA, Ince C, Kesecioglu J, Klinisch geneesmiddelenonderzoek bij acuut beslissingsonbekwame patiënten in de neurologie en de neurochirurgie; implicaties van nieuwe Europese regelgeving. NED TIJDSCHR GENEESKD 2004;148 (5):246-247 [PubMed]
Zuurbier CJ, Eerbeek O , Goedhart PT, Struys EA, Verhoeven NM, Jakobs C, Ince C, Inhibition of the pentose phosphate pathway decreases ischemia-reperfusion-induced creatine kinase release in the heart. CARDIOVASC RES 2004;62 (1):145-153 [PubMed]
Zuurbier CJ, Emons VM, Koeman A, Ince C. Mouse anesthesia in relation to optimal hemodynamics in: Ince C, editor. The physiological genomics of the critically ill mouse. Boston: Kluwer Academic Publishers; 2004., p. 23-34
Boerma EC, Ince C. The microcirculation of the gut in sepsis in: Gullo A, editors. Anesthesia, pain, intensive care and emergency medicine. S.l.: s.n.; 2003., p. 561-571
Buise M, van Bommel J, Ince C. Reflectance spectrophotometry and tissue oxygenation in experimental and clinical practice in: Vincent JL, editor. Yearbook of intensive care and emergency medicine 2003. S.l.: s.n.; 2003., p. 221-231
Dörffler-Melly J, de Kruif M, Schwarte LA, Franco RF, Florquin S, Spek CA, Ince C, Reitsma PH, ten Cate H, Functional thrombomodulin deficiency causes enhanced thrombus growth in a murine model of carotid artery thrombosis. BASIC RES CARDIOL 2003;98 (6):347-352 [PubMed]
Hardeman MR, Besselink GAJ, Ebbing I, de Korte D, Ince C, Verhoeven AJ, Laser-assisted optical rotational cell analyzer measurements reveal early changes in human RBC deformability induced by photodynamic treatment. TRANSFUSION 2003;43 (11):1533-1537 [PubMed]
Ince C, A special section on mouse physiological genomics. CLIN EXP PHARMACOL P 2003;30:867-909
Ince C, editor, The physiological genomics of the critically ill mouse. Boston: Kluwer Academic Publishers; 2003. -p.
Ince C, editor, The physiological genomics of the critically ill mouse. S.l.: Luwer Academic Publishers; 2003. -p.
Ince C, editor, The physiological genomics of the critically ill mouse. Amsterdam: Kluwer Academic Publishers; 2003. -p. ISBN 1-4020-7641-x
Pittner A, Nalos M, Asfar P, Yang Y, Ince C, Georgieff M, Brückner UB, Radermacher P, Fröba G, Mechanisms of inducible nitric oxide synthase (iNOS) inhibition-related improvement of gut mucosal acidosis during hyperdynamic porcine endotoxemia. INTENS CARE MED 2003;29 (2):312-316 [PubMed]
Spronk P, Ince C, Gardien M, Mathura K, Zandstra D, Nitroglycerin for septic shock - Reply. LANCET 2003;361 (9360):880
van Iterson M, Siegemund M, Burhop K, Ince C, Hemoglobin-based oxygen carrier provides heterogeneous microvascular oxygenation in heart and gut after hemorrhage in pigs. J TRAUMA 2003;55 (6):1111-1124 [PubMed]
Zuurbier CJ, Kruyver B, Eerbeek O , Mik EG, Ince C, Commonly used numbers of microspheres affect cardiac vascular resistance. J CARDIOVASC PHARM 2003;41 (2):223-232 [PubMed]
Asfar P, Nalos M, Pittner A, Theisen M, Ichai C, Ploner F, Georgieff M, Ince C, Brückner UB, Leverve XM, Radermacher P, Froeba G, Adenosine triphosphate-magnesium dichloride during hyperdynamic porcine endotoxemia: Effects on hepatosplanchnic oxygen exchange and metabolism. CRIT CARE MED 2002;30 (8):1826-1833 [PubMed]
Buwalda M, Ince C, Opening the microcirculation: can vasodilators be useful in sepsis?. INTENS CARE MED 2002;28 (9):1208-1217 [PubMed]
Dobbe JGG. Engineering developments in hemorheology. S.l.: s.n.; 2002. 133p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Grimbergen CA, Ince C; copromotor(s): Hardeman MR, Streekstra GJ)
Dobbe JGG, Hardeman MR, Streekstra GJ, Strackee J, Ince C, Grimbergen CA, Analyzing red blood cell-deformability distributions. BLOOD CELL MOL DIS 2002;28 (3):373-384 [PubMed]
Dobbe JGG, Streekstra GJ, Hardeman MR, Ince C, Grimbergen CA, Measurement of the distribution of red blood cell deformability using an automated rheoscope. CYTOMETRY 2002;50 (6):313-325 [PubMed]
Ince C, The 3rd International Amsterdam Mouse Symposium - Introduction. CLIN EXP PHARMACOL P 2002;29 (8):A69
Ince C, The microcirculation unveiled. AM J RESP CRIT CARE 2002;166 (1):1-2 [PubMed]
Jong WMC, Zuurbier CJ, de Winter RJ, van den Heuvel DAF, Reitsma PH, ten Cate H, Ince C, Fentanyl-fluanisone-midazolam combination results in more stable hemodynamics than does urethane alpha-chloralose and 2,2,2-tribromoethanol in mice. CONTEMP TOP LAB ANIM 2002;41 (3):28-32 [PubMed]
Mik EG, Donkersloot C, Raat NJH, Ince C, Excitation pulse deconvolution in luminescence lifetime analysis for oxygen measurements in vivo. PHOTOCHEM PHOTOBIOL 2002;76 (1):12-21 [PubMed]
Siegemund M, Racovitza I, Ince C. The rationale for vasodilator therapy in sepsis in: Vincent JL, editor. Yearbook of intensive care and emergency medicine 2002. Berlin Heidelberg New York: Springer-Verlag; 2002., p. 221-232
Spronk PE, Ince C, Gardien MJ, Mathura KR, Oudemans-van Straaten HM, Zandstra DF, Nitroglycerin in septic shock after intravascular volume resuscitation. LANCET 2002;360 (9343):1395-1396 [PubMed]
van Bommel J, Trouwborst A, Schwarte L, Siegemund M, Ince C, Henny CP, Intestinal and cerebral oxygenation during severe isovolemic hemodilution and subsequent hyperoxic ventilation in a pig model. ANESTHESIOLOGY 2002;97 (3):660-670 [PubMed]
van Bommel SM, Racovitza I, Ince C, Sepsis, microcirculation and vasodilators. NETH J CRIT CARE 2002;6:12-17
Zuurbier CJ, Emons VM, Ince C, Hemodynamics of anesthetized ventilated mouse models: aspects of anesthetics, fluid support, and strain. AM J PHYSIOL-HEART C 2002;282 (6):H2099-H2105 [PubMed]
Zuurbier CJ, Ince C, Post-ischaemic changes in the response time of oxygen consumption to demand in the isolated rat heart are mediated partly by calcium and glycolysis. PFLUG ARCH EUR J PHY 2002;443 (5-6):908-916 [PubMed]
Hardeman MR, Dobbe JG, Ince C, The Laser-assisted Optical Rotational Cell Analyzer (LORCA) as red blood cell aggregometer. CLIN HEMORHEOL MICRO 2001;25 (1):1-11 [PubMed]
Mathura KR, Bouma GJ, Ince C, Abnormal microcirculation in brain tumours during surgery. LANCET 2001;358 (9294):1698-1699 [PubMed]
Mathura KR, Vollebregt KC, Boer K, de Graaff JC, Ubbink DT, Ince C, Comparison of OPS imaging and conventional capillary microscopy to study the human microcirculation. J APPL PHYSIOL 2001;91 (1):74-78 [PubMed]
Tepaske R, Velthuis H, Oudemans-van Straaten HM, Heisterkamp SH, van Deventer SJ, Ince C, Eÿsman L, Kesecioglu J, Effect of preoperative oral immune-enhancing nutritional supplement on patients at high risk of infection after cardiac surgery: a randomised placebo-controlled trial. LANCET 2001;358 (9283):696-701 [PubMed]
Tugtekin IF, Radermacher P, Theisen M, Matejovic M, Stehr A, Ploner F, Matura K, Ince C, Georgieff M, Träger K, Increased ileal-mucosal-arterial PCO2 gap is associated with impaired villus microcirculation in endotoxic pigs. INTENS CARE MED 2001;27 (4):757-766 [PubMed]
van Bommel J, de Korte D, Lind A, Siegemund M, Trouwborst A, Verhoeven AJ, Ince C, Henny CP, The effect of the transfusion of stored RBCs on intestinal microvascular oxygenation in the rat. TRANSFUSION 2001;41 (12):1515-1523 [PubMed]
Vollebregt KC, Boer K, Mathura KR, de Graaff JC, Ubbink DT, Ince C, Impaired vascular function in women with pre-eclampsia observed with orthogonal polarisation spectral imaging. BJOG-INT J OBSTET GY 2001;108 (11):1148-1153 [PubMed]
Dörffler-Melly J, Schwarte LA, Ince C, Levi M, Mouse models of focal arterial and venous thrombosis. BASIC RES CARDIOL 2000;95 (6):503-509 [PubMed]
Schwarte LA, Zuurbier CJ, Ince C, Mechanical ventilation of mice. BASIC RES CARDIOL 2000;95 (6):510-520 [PubMed]
van Bommel J, Siegemund M, Henny CP, van den Heuvel DA, Trouwborst A, Ince C, Preservation of intestinal microvascular Po2 during normovolemic hemodilution in a rat model. J LAB CLIN MED 2000;135 (6):476-483 [PubMed]
Ashruf JF, Ince C, Bruining HA, Regional ischemia in hypertrophic Langendorff-perfused rat hearts. AM J PHYSIOL 1999;277 (4 Part 2):H1532-H1539 [PubMed]
Groner W, Winkelman JW, Harris AG, Ince C, Bouma GJ, Messmer K, Nadeau RG, Orthogonal polarization spectral imaging: a new method for study of the microcirculation. NAT MED 1999;5 (10):1209-1212 [PubMed]
Hardeman MR, Ince C, Clinical potential of in vitro measured red cell deformability, a myth?. CLIN HEMORHEOL MICRO 1999;21 (3-4):277-284 [PubMed]
Ince C, Sinaasappel M, Microcirculatory oxygenation and shunting in sepsis and shock. CRIT CARE MED 1999;27 (7):1369-1377 [PubMed]
Siegemund M, van Bommel J, Ince C, Assessment of regional tissue oxygenation. INTENS CARE MED 1999;25 (10):1044-1060 [PubMed]
Sinaasappel M, Donkersloot C, van Bommel J, Ince C, PO2 measurements in the rat intestinal microcirculation. AM J PHYSIOL 1999;276 (6 Part 1):G1515-G1520 [PubMed]
Sinaasappel M, van Iterson M, Ince C, Microvascular oxygen pressure in the pig intestine during haemorrhagic shock and resuscitation. J PHYSIOL-LONDON 1999;514 ( Pt 1):245-253 [PubMed]
Zuurbier CJ, van Iterson M, Ince C, Functional heterogeneity of oxygen supply-consumption ratio in the heart. CARDIOVASC RES 1999;44 (3):488-497 [PubMed]
Hardeman MR, Meinardi MM, Ince C, Vreeken J, Red blood cell rigidification during cyclosporin therapy: a possible early warning signal for adverse reactions. SCAND J CLIN LAB INV 1998;58 (8):617-623 [PubMed]
Trouwborst A, van Bommel J, Ince C, Henny CP, Monitoring normovolaemic haemodilution. BRIT J ANAESTH 1998;81 (Suppl. 1):73-78 [PubMed]
Unal N, Kanhai JK, Buijk SL, Pompe JC, Holland WP, Gültuna I, Ince C, Saygin B, Bruining HA, A novel method of evaluation of three heat-moisture exchangers in six different ventilator settings. INTENS CARE MED 1998;24 (2):138-146 [PubMed]
van Bommel J, Maas MA, Sinaasappel M, Ince C, Intestinal microvascular pO2 measurement with Pd-porphyrin phosphorescence in the mechanically ventilated mouse. ADV EXP MED BIOL 1998;454:189-193 [PubMed]
van Iterson M, Sinaasappel M, Burhop K, Trouwborst A, Ince C, Low-volume resuscitation with a hemoglobin-based oxygen carrier after hemorrhage improves gut microvascular oxygenation in swine. J LAB CLIN MED 1998;132 (5):421-431 [PubMed]
Avontuur JA, Bruining HA, Ince C, Nitric oxide causes dysfunction of coronary autoregulation in endotoxemic rats. CARDIOVASC RES 1997;35 (2):368-376 [PubMed]
Eerbeek O , Ince C, Weak spots inside the myocardium of a Langendorff rat heart observed by NADH videofluorometry. ADV EXP MED BIOL 1997;411:347-351 [PubMed]
Sinaasappel M, Ince C, Calibration of Pd-porphyrin phosphorescence for oxygen concentration measurements in vivo. J APPL PHYSIOL 1996;81 (5):2297-2303 [PubMed]
Ashruf JF, Coremans JM, Bruining HA, Ince C, Increase of cardiac work is associated with decrease of mitochondrial NADH. AM J PHYSIOL 1995;269 (3 Part 2):H856-H862 [PubMed]
Avontuur JA, Bruining HA, Ince C, Inhibition of nitric oxide synthesis causes myocardial ischemia in endotoxemic rats. CIRC RES 1995;76 (3):418-425 [PubMed]
Unal N, Pompe JC, Holland WP, Gültuna I, Huygen PE, Jabaaij K, Ince C, Saygin B, Bruining HA, An experimental set-up to test heat-moisture exchangers. INTENS CARE MED 1995;21 (2):142-148 [PubMed]
Ince C, Ashruf JF, Avontuur JA, Wieringa PA, Spaan JA, Bruining HA, Heterogeneity of the hypoxic state in rat heart is determined at capillary level. AM J PHYSIOL 1993;264 (2 Part 2):H294-H301 [PubMed]
Ince C, Vink H, Wieringa PA, Giezeman M, Spaan JA, Heterogeneous NADH fluorescence during post-anoxic reactive hyperemia in saline perfused rat heart. ADV EXP MED BIOL 1990;277:477-482 [PubMed]
Ince C, van Duijn B, Ypey DL, van Bavel E, Weidema F, Leijh PC, Ionic channels and membrane hyperpolarization in human macrophages. J MEMBRANE BIOL 1987;97 (3):251-258 [PubMed]
Ince C, van Bavel E, van Duijn B, Donkersloot K, Coremans A, Ypey DL, Verveen AA, Intracellular microelectrode measurements in small cells evaluated with the patch clamp technique. BIOPHYS J 1986;50 (6):1203-1209 [PubMed]
Ince C, Leijh PC, Meijer J, van Bavel E, Ypey DL, Oscillatory hyperpolarizations and resting membrane potentials of mouse fibroblast and macrophage cell lines. J PHYSIOL-LONDON 1984;352:625-635 [PubMed]
Key publications

Ince C, van Kuijen AM, Milstein DMJ, Yürük K, Folkow LP, Fokkens WJ, Blix AS, CHRISTMAS 2012: RESEARCH Why Rudolph's nose is red: observational study. BMJ-BRIT MED J 2012;345:e8311 [PubMed]
Ince C, Groeneveld ABJ, The case for 0.9% NaCl: is the undefendable, defensible?. KIDNEY INT 2014;86 (6):1087-1095 [PubMed]
Ince C, Guerci P, Why and when the microcirculation becomes disassociated from the macrocirculation. INTENS CARE MED 2016;42 (10):1645-1646 [PubMed]
Matejovic M, Ince C, Chawla LS, Blantz R, Molitoris BA, Rosner MH, Okusa MD, Kellum JA, Ronco C [Contributors: Kellum J, Okusa M, Ronco C, Rosner M, Agarwal A, Basile DP, Blantz R, Bonventre JV, Cantaluppi V, Chawla LS, Dong Z, Griffin M, Harris R, Humphreys B, Ince C, Matejovic M, McKay D, Mehta R, Molitoris B, Murray P, Nangaku M, Pickkers P, Portilla D, Rabb H, Singbartl K, Swaminathan S, Unwin R, Yang L]] , Renal Hemodynamics in AKI: In Search of New Treatment Targets. J AM SOC NEPHROL 2016;27 (1):49-58 [PubMed]
Wilson MH, Davagnanam I, Holland G, Dattani RS, Tamm A, Hirani SP, Kolfschoten N, Strycharczuk L, Green C, Thornton JS, Wright A, Edsell M, Kitchen ND, Sharp DJ, Ham TE, Murray A, Holloway CJ, Clarke K, Grocott MPW, Montgomery H, Imray C [Contributors: Ahuja V, Aref-Adib G, Burnham R, Chisholm A, Clarke K, Coates D, Coates M, Cook D, Cox M, Dhillon S, Dougall C, Doyle P, Duncan P, Edsell M, Edwards L, Evans L, Gardiner P, Grocott M, Gunning P, Hart N, Harrington J, Harvey J, Holloway C, Howard D, Hurlbut D, Imray C, Ince C, Jonas M, van der Kaaij J, Khosravi M, Kolfschoten N, Levett D, Luery H, Luks A, Martin D, McMorrow R, Meale P, Mitchell K, Montgomery H, Morgan G, Morgan J, Murray A, Mythen M, Newman S, O'Dwyer M, Pate J, Plant T, Pun M, Richards P, Richardson A, Rodway G, Simpson J, Stroud C, Stroud M, Stygall J, Symons B, Szawarski P, van Tulleken C, Vercueil A, Wandrag L, Wilson M, Windsor J]] , Cerebral venous system and anatomical predisposition to high-altitude headache. ANN NEUROL 2013;73 (3):381-389 [PubMed]


All Publications

Research programmes

Cardiovascular aspects of Surgery and Critical Illness

Our research group has three main lines of research; 1)Clinical microcirculation research in perioperative phase 2)The red blood cell in critical illnes and surgery, 3)Experimental investigations into microcirculatory and mitochondrial dysfunction in sepsis, shock and resuscitation. Our research is translational in nature where we develop concepts and techniques fron bench-to-bedside. In theme 1 we identified 5 different classes of microcirculatory alterations in distributive shock. We identified microcirculatory recruitment maneuvers in the treatment of sepsis, and developed microcirculation research in cardiac and maxillofacial surgery. In theme 2 we investigated how storage affects the quality of blood transfusions. We found that fluid resuscitation causes enhancement in renal  oxygen consumption and redistribution of oxygen transport. This line of research resulted in a grant awarded by the Landsteiner Foundation for Blood Transfusion Research. In theme 3 we developed a two-wave length technique for measuring the redistribution of tissue oxygenation in organs. Our year was rounded off by our publication in Nature Methods where we identified an endogenous mitochondrial molecule, protoporyphrin IX, with which, using quenching of delayed fluorescence, mitochondrial pO2 can be measured quantitatively  in vivo. This new technique is expected to provide important new insights into the nature of mitochondrial dysfunction in critical illness.

Theme: Cardiovascular Diseases

Faculty
Prof. dr. C. Ince
B. Ergin MSc
Drs. Z. Uz

Postdocs
E.C. Boerma MD PhD
Dr. D.M.J. Milstein

PhD Students
B. Ergin MSc
M.P. Hilty
Z. Uz
G. Veenstra
P. Guerci (University Hospital Nancy)
H.W. He (University Union Hospital Peking)
V.S. Kanoore Edul MD

Others
Y. Ince

Other research related activities
  • None reported
Current research funding
  • AMC
  • Nierstichting Nederland