• Male

Dr. F.M. Wensveen PhD

Position: Postdoc
Main activities: Research
Specialisation: Immunology
foto
Focus of research:

 Immunology

AMC themes: Infection & Immunity
Departments: Experimental Immunology
Jelenčić V, Lenartić M, Wensveen FM, Polić B, NKG2D: A versatile player in the immune system. IMMUNOL LETT 2017;189:48-53 [PubMed]
Kavazovic I, Lenartic M, Jelencic V, Jurkovic S, Lemmermann NAW, Jonjic S, Polic B, Wensveen FM, NKG2D stimulation of CD8(+) T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice. EUR J IMMUNOL 2017;47 (7):1123-1135
Lenartić M, Jelenčić V, Zafirova B, Ožanič M, Marečić V, Jurković S, Sexl V, Šantić M, Wensveen FM, Polić B, NKG2D Promotes B1a Cell Development and Protection against Bacterial Infection. J IMMUNOL 2017;198 (4):1531-1542 [PubMed]
Wensveen FM, Slinger E, van Attekum MHA, Brink R, Eldering E, Antigen-affinity controls pre-germinal center B cell selection by promoting Mcl-1 induction through BAFF receptor signaling (vol 6, 35673, 2016). SCI REP-UK 2017;7:39366 [PubMed]
Slinger E, Wensveen FM, Guikema JE, Kater AP, Eldering E, Chronic lymphocytic leukemia development is accelerated in mice with deficiency of the pro-apoptotic regulator NOXA. HAEMATOLOGICA 2016;101 (9):e376-e377 [PubMed]
Wensveen FM, Slinger E, van Attekum MHA, Brink R, Eldering E, Antigen-affinity controls pregerminal centser B cell selection by promoting Mcl-1 induction through BAFF receptor signaling. SCI REP-UK 2016;6:35673 [PubMed]
Wensveen FM, Valentić S, Šestan M, Turk Wensveen T, Polić B, Interactions between adipose tissue and the immune system in health and malnutrition. SEMIN IMMUNOL 2015;27 (5):322-333 [PubMed]
Wensveen FM, Valentić S, Šestan M, Turk Wensveen T, Polić B, The "Big Bang" in obese fat: Events initiating obesity-induced adipose tissue inflammation. EUR J IMMUNOL 2015;45 (9):2446-2456 [PubMed]
Welten SPM, Redeker A, Franken KL, Benedict CA, Yagita H, Wensveen FM, Borst J, Melief CJM, van Lier RAW, van Gisbergen KPJM, Arens R, CD27-CD70 costimulation controls T cell immunity during acute and persistent cytomegalovirus infection. J VIROL 2013;87 (12):6851-6865 [PubMed]
Wensveen FM, Geest CR, Libregts SFWM, Derks IAM, Ekert PG, Labi V, Villunger A, Nolte MA, Eldering E, BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis. APOPTOSIS 2013;18 (11):1306-1318 [PubMed]
Wensveen FM, Klarenbeek PL, van Gisbergen KPJM, Pascutti MF, Derks IAM, van Schaik BDC, ten Brinke A, de Vries N, Cekinovic D, Jonjic S, van Lier RAW, Eldering E, Pro-apoptotic protein Noxa regulates memory T cell population size and protects against lethal immunopathology. J IMMUNOL 2013;190 (3):1180-1191 [PubMed]
Wensveen FM, Lenartic M, Jelencic V, Lemmermann NAW, ten Brinke A, Jonjic S, Polic B, NKG2D induces Mcl-1 expression and mediates survival of CD8 memory T cell precursors via phosphatidylinositol 3-kinase. J IMMUNOL 2013;191 (3):1307-1315 [PubMed]
van Gisbergen KPJM, Kragten NAM, Hertoghs KML, Wensveen FM, Jonjic S, Hamann J, Nolte MA, van Lier RAW, Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation. NAT IMMUNOL 2012;13 (9):864-871 [PubMed]
Wensveen FM, Derks IAM, van Gisbergen KPJM, de Bruin AM, Meijers JCM, Yigittop H, Nolte MA, Eldering E, van Lier RAW, BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation. BLOOD 2012;119 (6):1440-1449 [PubMed]
Wensveen FM, Unger PPA, Kragten NAM, Derks IAM, ten Brinke A, Arens R, van Lier RAW, Eldering E, van Gisbergen KPJM, CD70-Driven Costimulation Induces Survival or Fas-Mediated Apoptosis of T Cells Depending on Antigenic Load. J IMMUNOL 2012;188 (9):4256-4267 [PubMed]
Wensveen FM, van Gisbergen KPJM, Eldering E, The fourth dimension in immunological space: how the struggle for nutrients selects high-affinity lymphocytes. IMMUNOL REV 2012;249 (1):84-103 [PubMed]
Libregts SF, Gutiérrez L, de Bruin AM, Wensveen FM, Papadopoulos P, van Ijcken W, Ozgür Z, Philipsen S, Nolte MA, Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis. BLOOD 2011;118 (9):2578-2588 [PubMed]
van Gisbergen KPJM, Klarenbeek PL, Kragten NAM, Unger PPA, Nieuwenhuis MBB, Wensveen FM, ten Brinke A, Tak PP, Eldering E, Nolte MA, van Lier RAW, The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants. IMMUNITY 2011;35 (1):97-108 [PubMed]
Wensveen FM, Alves NL, Derks IAM, Reedquist KA, Eldering E, Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1. APOPTOSIS 2011;16 (7):708-721 [PubMed]
Zeilstra J, Joosten SPJ, Wensveen FM, Dessing MC, Schütze DM, Eldering E, Spaargaren M, Pals ST, WNT signaling controls expression of pro-apoptotic BOK and BAX in intestinal cancer. BIOCHEM BIOPH RES CO 2011;406 (1):1-6 [PubMed]
van de Laar L, Buitenhuis M, Wensveen FM, Janssen HLA, Coffer PJ, Woltman AM, Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin signaling. J IMMUNOL 2010;184 (12):6600-6611 [PubMed]
Wensveen FM. Survival of the fittest clone. Pro-apoptotic protein Noxa controls of lymphocytes under competitive conditions. s.l.: s.n.; 2010. 198p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Lier RAW; copromotor(s): Eldering EF)
Wensveen FM, van Gisbergen KPJM, Derks IAM, Gerlach C, Schumacher TN, van Lier RAW, Eldering E, Apoptosis Threshold Set by Noxa and Mcl-1 after T Cell Activation Regulates Competitive Selection of High-Affinity Clones. IMMUNITY 2010;32 (6):754-765 [PubMed]
van Olffen RW, Koning N, van Gisbergen KPJM, Wensveen FM, Hoek RM, Boon L, Hamann J, van Lier RAW, Nolte MA, GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo. J IMMUNOL 2009;182 (12):7490-7500 [PubMed]
Hallaert DYH, Spijker R, Jak M, Derks IAM, Alves NL, Wensveen FM, de Boer JP, de Jong D, Green SR, van Oers MHJ, Eldering E, Crosstalk among Bcl-2 family members in B-CLL: seliciclib acts via the Mcl-1/Noxa axis and gradual exhaustion of Bcl-2 protection. CELL DEATH DIFFER 2007;14 (11):1958-1967 [PubMed]
Key publications

Wensveen FM, van Gisbergen KPJM, Derks IAM, Gerlach C, Schumacher TN, van Lier RAW, Eldering E, Apoptosis Threshold Set by Noxa and Mcl-1 after T Cell Activation Regulates Competitive Selection of High-Affinity Clones. IMMUNITY 2010;32 (6):754-765 [PubMed]
Wensveen FM, Derks IAM, van Gisbergen KPJM, de Bruin AM, Meijers JCM, Yigittop H, Nolte MA, Eldering E, van Lier RAW, BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation. BLOOD 2012;119 (6):1440-1449 [PubMed]
Wensveen FM, Lenartic M, Jelencic V, Lemmermann NAW, ten Brinke A, Jonjic S, Polic B, NKG2D induces Mcl-1 expression and mediates survival of CD8 memory T cell precursors via phosphatidylinositol 3-kinase. J IMMUNOL 2013;191 (3):1307-1315 [PubMed]
Wensveen FM, van Gisbergen KPJM, Eldering E, The fourth dimension in immunological space: how the struggle for nutrients selects high-affinity lymphocytes. IMMUNOL REV 2012;249 (1):84-103 [PubMed]
Wensveen FM, Klarenbeek PL, van Gisbergen KPJM, Pascutti MF, Derks IAM, van Schaik BDC, ten Brinke A, de Vries N, Cekinovic D, Jonjic S, van Lier RAW, Eldering E, Pro-apoptotic protein Noxa regulates memory T cell population size and protects against lethal immunopathology. J IMMUNOL 2013;190 (3):1180-1191 [PubMed]


All Publications

Research programmes

Prof. dr. E. Eldering (Apoptosis regulation in immuno-hematology)

Other research related activities
  • None reported
Current research funding
  • None reported