• Female

Dr. G.J.W. van der Windt

Position: Postdoc
Main activities: Research
Specialisation: Immuno-metabolism
foto
Focus of research:

Investigating the impact of cellular metabolism on immune cell function during infections and cancer.

AMC themes: Infection & Immunity, Oncology
Departments: Experimental Immunology
Buck MD, O'Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJW, Chen Q, Huang SCC, O'Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, Pearce EL, Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming. CELL 2016;166 (1):63-76 [PubMed]
Siska PJ, van der Windt GJW, Kishton RJ, Cohen S, Eisner W, MacIver NJ, Kater AP, Weinberg JB, Rathmell JC, Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia. J IMMUNOL 2016;197 (6):2532-2540 [PubMed]
van der Windt GJW, Chang CH, Pearce EL, Measuring Bioenergetics in T Cells Using a Seahorse Extracellular Flux Analyzer. CURR PROTOC IMMUNOL 2016;113:3.16B.1-3.16B.14 [PubMed]
Blagih J, Coulombe F, Vincent EE, Dupuy F, Galicia-Vázquez G, Yurchenko E, Raissi TC, van der Windt GJW, Viollet B, Pearce EL, Pelletier J, Piccirillo CA, Krawczyk CM, Divangahi M, Jones RG, The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo. IMMUNITY 2015;42 (1):41-54 [PubMed]
Chang CH, Qiu J, O'Sullivan D, Buck MD, Noguchi T, Curtis JD, Chen Q, Gindin M, Gubin MM, van der Windt GJW, Tonc E, Schreiber RD, Pearce EJ, Pearce EL, Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression. CELL 2015;162 (6):1229-1241 [PubMed]
Kater AP, van der Windt GJW, PD-L1 blockade: rejuvenating T cells in CLL. BLOOD 2015;126 (2):126-128 [PubMed]
Richner JM, Gmyrek GB, Govero J, Tu Y, van der Windt GJW, Metcalf TU, Haddad EK, Textor J, Miller MJ, Diamond MS, Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection. PLOS PATHOG 2015;11 (7):e1005027 [PubMed]
Everts B, Amiel E, Huang SCC, Smith AM, Chang CH, Lam WY, Redmann V, Freitas TC, Blagih J, van der Windt GJW, Artyomov MN, Jones RG, Pearce EL, Pearce EJ, TLR-driven early glycolytic reprogramming via the kinases TBK1-IKK epsilon supports the anabolic demands of dendritic cell activation. NAT IMMUNOL 2014;15 (4):323-+ [PubMed]
O'Sullivan D, van der Windt GJW, Huang SCC, Curtis JD, Chang CH, Buck MD, Qiu J, Smith AM, Lam WY, DiPlato LM, Hsu FF, Birnbaum MJ, Pearce EJ, Pearce EL, Memory CD8(+) T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development. IMMUNITY 2014;41 (1):75-88 [PubMed]
Chang CH, Curtis JD, Maggi LB Jr, Faubert B, Villarino AV, O'Sullivan D, Huang SCC, van der Windt GJW, Blagih J, Qiu J, Weber JD, Pearce EJ, Jones RG, Pearce EL, Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis. CELL 2013;153 (6):1239-1251 [PubMed]
van der Windt GJW, O'Sullivan D, Everts B, Huang SCC, Buck MD, Curtis JD, Chang CH, Smith AM, Ai T, Faubert B, Jones RG, Pearce EJ, Pearce EL, CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability. P NATL ACAD SCI USA 2013;110 (35):14336-14341 [PubMed]
Everts B, Amiel E, van der Windt GJW, Freitas TC, Chott R, Yarasheski KE, Pearce EL, Pearce EJ, Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. BLOOD 2012;120 (7):1422-1431 [PubMed]
Hoogerwerf JJ, van der Windt GJW, Blok DC, Hoogendijk AJ, de Vos AF, van 't Veer C, Florquin S, Kobayashi KS, Flavell RA, van der Poll T, Interleukin-1 Receptor-Associated Kinase M-Deficient Mice Demonstrate an Improved Host Defense during Gram-negative Pneumonia. MOL MED 2012;18 (7):1067-1075 [PubMed]
Kager LM, van der Windt GJW, Wieland CW, Florquin S, van 't Veer C, van der Poll T, Plasminogen activator inhibitor type I may contribute to transient, non-specific changes in immunity in the subacute phase of murine tuberculosis. MICROBES INFECT 2012;14 (9):748-755 [PubMed]
van der Windt GJW, Blok DC, Hoogerwerf JJ, Lammers AJJ, de Vos AF, van't Veer C, Florquin S, Kobayashi KS, Flavell RA, van der Poll T, Interleukin 1 Receptor-Associated Kinase M Impairs Host Defense During Pneumococcal Pneumonia. J INFECT DIS 2012;205 (12):1849-1857 [PubMed]
van der Windt GJW, Everts B, Chang CH, Curtis JD, Freitas TC, Amiel E, Pearce EJ, Pearce EL, Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8(+) T Cell Memory Development. IMMUNITY 2012;36 (1):68-78 [PubMed]
van der Windt GJW, Pearce EL, Metabolic switching and fuel choice during T-cell differentiation and memory development. IMMUNOL REV 2012;249 (1):27-42 [PubMed]
van Zoelen MAD, Wieland CW, van der Windt GJW, Florquin S, Nawroth PP, Bierhaus A, van der Poll T, Receptor for advanced glycation end products is protective during murine tuberculosis. MOL IMMUNOL 2012;52 (3-4):183-189 [PubMed]
Weehuizen TAF, Wieland CW, van der Windt GJW, Duitman JW, Boon L, Day NPJ, Peacock SJ, van der Poll T, Wiersinga WJ, Expression and Function of Transforming Growth Factor beta in Melioidosis. INFECT IMMUN 2012;80 (5):1853-1857 [PubMed]
van der Windt GJW, Hoogendijk AJ, de Vos AF, Kerver ME, Florquin S, van der Poll T, The role of CD44 in the acute and resolution phase of the host response during pneumococcal pneumonia. LAB INVEST 2011;91 (4):588-597 [PubMed]
van der Windt GJW, Hoogendijk AJ, Schouten M, Hommes TJ, de Vos AF, Florquin S, van der Poll T, Osteopontin Impairs Host Defense During Pneumococcal Pneumonia. J INFECT DIS 2011;203 (12):1850-1858 [PubMed]
van der Windt GJW, Schouten M, Zeerleder S, Florquin S, van der Poll T, CD44 Is Protective during Hyperoxia-Induced Lung Injury. AM J RESP CELL MOL 2011;44 (3):377-383 [PubMed]
van der Windt GJW. The role of CD44 and osteopontin in infection and imflammation. s.l.: s.n.; 2010. 224p. ISBN 9789090251981 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van der Poll T; copromotor(s): de Vos AF)
van der Windt GJW, Florquin S, de Vos AF, van't Veer C, Queiroz KCS, Liang J, Jiang D, Noble PW, van der Poll T, CD44 Deficiency Is Associated with Increased Bacterial Clearance but Enhanced Lung Inflammation During Gram-Negative Pneumonia. AM J PATHOL 2010;177 (5):2483-2494 [PubMed]
van der Windt GJW, Hoogerwerf JJ, de Vos AF, Florquin S, van der Poll T, Osteopontin promotes host defense during Klebsiella pneumoniae-induced pneumonia. EUR RESPIR J 2010;36 (6):1337-1345 [PubMed]
van der Windt GJW, van 't Veer C, Florquin S, van der Poll T, CD44 deficiency is associated with enhanced Escherichia coli-induced proinflammatory cytokine and chemokine release by peritoneal macrophages. INFECT IMMUN 2010;78 (1):115-124 [PubMed]
van der Windt GJW, Wiersinga WJ, Wieland CW, Tjia ICSI, Day NP, Peacock SJ, Florquin S, van der Poll T, Osteopontin Impairs Host Defense during Established Gram-Negative Sepsis Caused by Burkholderia pseudomallei (Melioidosis). PLOS NEGLECT TROP D 2010;4 (8):e806 [PubMed]
Wiersinga WJ, Calandra T, Kager LM, van der Windt GJW, Roger T, le Roy D, Florquin S, Peacock SJ, Sweep FCGJ, van der Poll T, Expression and Function of Macrophage Migration Inhibitory Factor (MIF) in Melioidosis. PLOS NEGLECT TROP D 2010;4 (2):e605 [PubMed]
Wiersinga WJ, Kager LM, Hovius JWR, van der Windt GJW, de Vos AF, Meijers JCM, Roelofs JJ, Dondorp A, Levi M, Day NP, Peacock SJ, van der Poll T, Urokinase Receptor Is Necessary for Bacterial Defense against Pneumonia-Derived Septic Melioidosis by Facilitating Phagocytosis. J IMMUNOL 2010;184 (6):3079-3086 [PubMed]
Hovius JWR, Bijlsma MF, van der Windt GJW, Wiersinga WJ, Boukens BJD, Coumou J, Oei A, de Beer R, de Vos AF, van 't Veer C, van Dam AP, Wang P, Fikrig E, Levi MM, Roelofs JJTH, van der Poll T, The Urokinase Receptor (uPAR) Facilitates Clearance of Borrelia burgdorferi. PLOS PATHOG 2009;5 (5):e1000447 [PubMed]
van der Windt GJW, Wieland CW, Wiersinga WJ, Florquin S, van der Poll T, Osteopontin is not crucial to protective immunity during murine tuberculosis. IMMUNOLOGY 2009;128 (1 Suppl):e766-e776 [PubMed]
Wieland CW, van der Windt GJW, Florquin S, McKenzie ANJ, van der Poll T, ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis. MICROBES INFECT 2009;11 (4):524-530 [PubMed]
Wieland CW, van der Windt GJW, Wiersinga WJ, Florquin S, van der Poll T, CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis. IMMUNOLOGY 2008;125 (2):272-279 [PubMed]
Wiersinga WJ, Wieland CW, van der Windt GJW, de Boer A, Florquin S, Dondorp A, Day NP, Peacock SJ, van der Poll T, Endogenous interleukin-18 improves the early antimicrobial host response in severe melioidosis. INFECT IMMUN 2007;75 (8):3739-3746 [PubMed]
Key publications

van der Windt GJW, Everts B, Chang CH, Curtis JD, Freitas TC, Amiel E, Pearce EJ, Pearce EL, Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8(+) T Cell Memory Development. IMMUNITY 2012;36 (1):68-78 [PubMed]
van der Windt GJW, Pearce EL, Metabolic switching and fuel choice during T-cell differentiation and memory development. IMMUNOL REV 2012;249 (1):27-42 [PubMed]
van der Windt GJW, O'Sullivan D, Everts B, Huang SCC, Buck MD, Curtis JD, Chang CH, Smith AM, Ai T, Faubert B, Jones RG, Pearce EJ, Pearce EL, CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability. P NATL ACAD SCI USA 2013;110 (35):14336-14341 [PubMed]
van der Windt GJW, Chang CH, Pearce EL, Measuring Bioenergetics in T Cells Using a Seahorse Extracellular Flux Analyzer. CURR PROTOC IMMUNOL 2016;113:3.16B.1-3.16B.14 [PubMed]
Siska PJ, van der Windt GJW, Kishton RJ, Cohen S, Eisner W, MacIver NJ, Kater AP, Weinberg JB, Rathmell JC, Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia. J IMMUNOL 2016;197 (6):2532-2540 [PubMed]


All Publications

Research programmes

Prof. dr. E. Eldering (Apoptosis regulation in immuno-hematology)

Prof. dr. A.P. Kater MD PhD (development of, circumvention of and novel strategies for (development of) chemorefractory CLL)

Other research related activities
  • None reported
Current research funding
  • None reported