• Principal Investigator
  • Female

Dr. J. Kluin MD PhD

Position: Associate professor (UHD)
Main activities: Patient care
Specialisation: Congenital cardiac surgery in pediatric and adult patients. Heart valve reconstruction surgery.
foto J. Kluin is one of the AMC Principal Investigators
Focus of research:

- regenerative medicine

- heart valve tissue engineering

- imaging (4D flow MRI) of cardiac defects

- surgery for aortic valve regurgitation and aortic aneurysms

- congenital heart surgery

- surgery for asymptomatic patients with severe mitral regurgitation

- aortic valve homeostasis

AMC themes: Cardiovascular Diseases
Departments: Cardiothoracic Surgery
Barili F, Freemantle N, Folliguet T, Muneretto C, de Bonis M, Czerny M, Obadia JF, Al-Attar N, Bonaros N, Kluin J, Lorusso R, Punjabi P, Sadaba R, Suwalski P, Benedetto U, Böning A, Falk V, Sousa-Uva M, Kappetein PA, Menicanti L, The flaws in the detail of an observational study on transcatheter aortic valve implantation versus surgical aortic valve replacement in intermediate-risks patients. EUR J CARDIO-THORAC 2017;51 (6):1031-1035 [PubMed]
de Heer F, Gökalp AL, Kluin J, Takkenberg JJM, Measuring what matters to the patient: health related quality of life after aortic valve and thoracic aortic surgery. GEN THORAC CARDIOVASC SURG 2017;ahead of print [PubMed]
Etnel JRG, van Dijk APJ, Kluin J, Bertels RA, Utens EMWJ, van Galen E, Bogers AJJC, Takkenberg JJM, Development of an Online, Evidence-Based Patient Information Portal for Congenital Heart Disease: A Pilot Study. FRONT CARDIOVASC MED 2017;4:25 [PubMed]
Farag ES, Planken RN, Boekholdt SM, Kluin J, Systolic anterior motion of the tricuspid valve in a patient with hypertrophic obstructive cardiomyopathy. INTERACT CARDIOV TH 2017;25 (3):496-498 [PubMed]
Jansen R, Hart EA, Peters M, Urgel K, Kluin J, Tietge WJ, Zwart K, Sybrandy KC, Cramer MJM, Chamuleau SAJ, An easy-to-use scoring index to determine severity of mitral regurgitation by 2D echocardiography in clinical practice. ECHOCARDIOGR-J CARD 2017;34 (9):1275-1283 [PubMed]
Jansen R, Kluin J, Ray SG, Cramer MJM, Suyker WJL, Chamuleau SAJ, Identification of the Asymptomatic Patient With Severe Mitral Regurgitation: Discrepancy Between Research and Clinical Practice. CARDIOL REV 2017;25 (3):110-116 [PubMed]
Kluin J, Sojak V, Koolbergen DR, Boon R, Bökenkamp R, Hazekamp MG, Fifteen years' experience with the use of artificial chords for valve reconstruction in children†. EUR J CARDIO-THORAC 2017;ahead of print [PubMed]
Kluin J, Talacua H , Smits AIPM, Emmert MY, Brugmans MCP, Fioretta ES, Dijkman PE, Söntjens SHM, Duijvelshoff R, Dekker S, Janssen-van den Broek MWJT, Lintas V, Vink A, Hoerstrup SP, Janssen HM, Dankers PYW, Baaijens FPT, Bouten CVC, In situ heart valve tissue engineering using a bioresorbable elastomeric implant - From material design to 12 months follow-up in sheep. BIOMATERIALS 2017;125:101-117 [PubMed]
Kluin J, Wilde AAM, Pinto Y, van Herwerden LA, To Add or Not to Add Mitral Valve Surgery to Septal Myectomy in HOCM Patients. J AM COLL CARDIOL 2017;69 (17):2250 [PubMed]
Korteland NM, Ahmed Y, Koolbergen DR, Brouwer M, de Heer F, Kluin J, Bruggemans EF, Klautz RJM, Stiggelbout AM, Bucx JJJ, Roos-Hesselink JW, Polak P, Markou T, van den Broek I, Ligthart R, Bogers AJJC, Takkenberg JJM, Does the Use of a Decision Aid Improve Decision Making in Prosthetic Heart Valve Selection? A Multicenter Randomized Trial. CIRC-CARDIOVASC QUAL 2017;10 (2):UNSP e003178 [PubMed]
van Rijswijk JW, Vink A, Martina JR, Ramjankhan FZ, Goldschmeding R, de Jonge N, Kluin J, Pathology of aortic valve remodeling after continuous-flow left ventricular assist device support. J HEART LUNG TRANSPL 2017;36 (1):113-116 [PubMed]
van Rijswijk JW, Vink A, van Herwerden LA, Kluin J, Recurrent carcinoid involvement of a tricuspid bioprosthesis. EUR J CARDIO-THORAC 2017;51 (5):1015 [PubMed]
Hjortnaes J, Goettsch C, Hutcheson JD, Camci-Unal G, Lax L, Scherer K, Body S, Schoen FJ, Kluin J, Khademhosseini A, Aikawa E, Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation. J MOL CELL CARDIOL 2016;94:13-20 [PubMed]
Huygens SA, Rutten-van Mölken MPMH, Bekkers JA, Bogers AJJC, Bouten CVC, Chamuleau SAJ, de Jaegere PPT, Kappetein AP, Kluin J, van Mieghem NMDA, Versteegh MIM, Witsenburg M, Takkenberg JJM, Conceptual model for early health technology assessment of current and novel heart valve interventions. OPEN HEART 2016;3 (2):e000500 [PubMed]
Kluin J, Koolbergen DR, Sojak V, Hazekamp MG, Valve-sparing root replacement in children. EUR J CARDIO-THORAC 2016;50 (3):476-481 [PubMed]
Muylaert DEP, van Almen GC, Talacua H , Fledderus JO, Kluin J, Hendrikse SIS, van Dongen JLJ, Sijbesma E, Bosman AW, Mes T, Thakkar SH, Smits AIPM, Bouten CVC, Dankers PYW, Verhaar MC, Early in-situ cellularization of a supramolecular vascular graft is modified by synthetic stromal cell-derived factor-1α derived peptides. BIOMATERIALS 2016;76:187-195 [PubMed]
Talacua H. In Situ Cardiovascular Tissue Engineering. S.l.: s.n.; 2016. 252p. ISBN 978-94-6233-491-5 Proefschrift Utrecht University, UMCU. (Promotor(s): van Herwerden LA; copromotor(s): Kluin J)
van Almen GC, Talacua H , Ippel BD, Mollet BB, Ramaekers M, Simonet M, Smits AIPM, Bouten CVC, Kluin J, Dankers PYW, Development of Non-Cell Adhesive Vascular Grafts Using Supramolecular Building Blocks. MACROMOL BIOSCI 2016;16 (3):350-362 [PubMed]
Basir A, de Groot P, Gründeman PF, Tersteeg C, Maas C, Barendrecht A, van Herwaarden J, Kluin J, Moll F, Pasterkamp G, Roest M, In Vitro Hemocompatibility Testing of Dyneema Purity Fibers in Blood Contact. INNOVATIONS (PHILA) 2015;10 (3):195-201 [PubMed]
Hjortnaes J. Calcific aortic valve disease: Shedding light on its onset. S.l.: s.n.; 2015. 262p. ISBN 978-94-6299-189-7 Proefschrift Utrecht University, UMCU. (Promotor(s): van Herwerden LA; copromotor(s): Kluin J, Aikawa E)
Hjortnaes J, Camci-Unal G, Hutcheson JD, Jung SM, Schoen FJ, Kluin J, Aikawa E, Khademhosseini A, Directing Valvular Interstitial Cell Myofibroblast-Like Differentiation in a Hybrid Hydrogel Platform. ADV HEALTHC MATER 2015;4 (1):121-130 [PubMed]
Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J, Aikawa E, Valvular interstitial cells suppress calcification of valvular endothelial cells. ATHEROSCLEROSIS 2015;242 (1):251-260 [PubMed]
Jacob KA, de Heer LM, de Heer F, Kluin J, Chronic alcoholic donors in heart transplantation: A mortality meta-analysis. INT J CARDIOL 2015;191:7-10 [PubMed]
Jacob KA, Dieleman JM, Nathoe HM, van Osch D, de Waal EEC, Cramer MJ, Kluin J, van Dijk D, The effects of intraoperative dexamethasone on left atrial function and postoperative atrial fibrillation in cardiac surgical patients. NETH HEART J 2015;23 (3):168-173 [PubMed]
Jacob KA, Hjortnaes J, Kranenburg G, de Heer F, Kluin J, Mortality after cardiac surgery in patients with liver cirrhosis classified by the Child-Pugh score. INTERACT CARDIOV TH 2015;20 (4):520-530 [PubMed]
Jacob KA, Leaf DE, Dieleman JM, van Dijk D, Nierich AP, Rosseel PM, van der Maaten JM, Hofland J, Diephuis JC, de Lange F, Boer C, Kluin J, Waikar SS, Intraoperative High-Dose Dexamethasone and Severe AKI after Cardiac Surgery. J AM SOC NEPHROL 2015;26 (12):2947-2951 [PubMed]
Korteland NM, Bras FJ, van Hout FMA, Kluin J, Klautz RJM, Bogers AJJC, Takkenberg JJM, Prosthetic aortic valve selection: current patient experience, preferences and knowledge. OPEN HEART 2015;2 (1):e000237 [PubMed]
Samim M, Agostoni P, Hendrikse J, Budde RPJ, Nijhoff F, Kluin J, Ramjankhan F, Doevendans PA, Stella PR, Embrella embolic deflection device for cerebral protection during transcatheter aortic valve replacement. J THORAC CARDIOV SUR 2015;149 (3):799-+ [PubMed]
Talacua H , Smits AIPM, Muylaert DEP, van Rijswijk JW, Vink A, Verhaar MC, Driessen-Mol A, van Herwerden LA, Bouten CVC, Kluin J, Baaijens FPT, In Situ Tissue Engineering of Functional Small-Diameter Blood Vessels by Host Circulating Cells Only. TISSUE ENG 2015;21 (19-20):2583-2594 [PubMed]
van Osch D, Dieleman JM, Nathoe HM, Boasson MP, Kluin J, Bunge JJH, Nierich AP, Rosseel PM, van der Maaten JM, Hofland J, Diephuis JC, de Lange F, Boer C, van Dijk D [Contributors: Bredée JJ, Buhre WF, Dieleman JM, van Dijk D, van Herwerden LA, Kalkman CJ, van Klarenbosch J, Moons KG, Nathoe HM, Numan SC, Ottens TH, Roes KC, Sauer AMC, Slooter AJ, van Osch D, Jacob KA, Klinieken I, Nierich AP, Ennema JJ, Ziekenhuis A, Rosseel PM, van der Meer NJ, van der Maaten JM, Cernak V, Hofland J, van Thiel RJ, Diephuis JC, Schepp RM, Haenen J, de Lange F, Boer C, de Jong JR, Tijssen JG]] , Intraoperative High-Dose Dexamethasone in Cardiac Surgery and the Risk of Rethoracotomy. ANN THORAC SURG 2015;100 (6):2237-2243 [PubMed]
van Osch D, Dieleman JM, van Dijk D, Jacob KA, Kluin J, Doevendans PA, Nathoe HM [Contributors: Bredée JJ, Buhre WF, Dieleman JM, van Dijk D, van Herwerden LA, Kalkman CJ, van Klarenbosch J, Moons KG, Nathoe HM, Numan SC, Ottens TH, Roes KC, Sauer AMC, Slooter AJ, van Osch D, Jacob KA, Nierich AP, Ennema JJ, Rosseel PM, van der Meer NJ, van der Maaten JM, Cernak V, Hofland J, van Thiel RJ, Diephuis JC, Schepp RM, Haenen J, de Lange F, Boer C, de Jong JR, Tijssen JG]] , Dexamethasone for the prevention of postoperative atrial fibrillation. INT J CARDIOL 2015;182:431-437 [PubMed]
van Rijswijk JW, Willemink MJ, Kluin J, Vink A, Incidental necropsy finding of a quadricuspid aortic valve. CARDIOVASC PATHOL 2015;24 (4):258-259 [PubMed]
[Contributors: Keating BJ, van Setten J, Jacobson PA, Holmes MV, Verma SS, Chandrupatla HR, Nair N, Gao H, Li YR, Chang BL, Wong C, Phillips R, Cole BS, Mukhtar E, Zhang W, Cao H, Mohebnasab M, Hou C, Lee T, Steel L, Shaked O, Garifallou J, Miller MB, Karczewski KJ, Akdere A, Gonzalez A, Lloyd KM, McGinn D, Michaud Z, Colasacco A, Lek M, Fu Y, Pawashe M, Guettouche T, Himes A, Perez L, Guan W, Wu B, Schladt D, Menon M, Zhang Z, Tragante V, de Jonge N, Otten HG, de Weger RA, van de Graaf EA, Baan CC, Manintveld OC, de Vlaminck I, Piening BD, Strehl C, Shaw M, Snieder H, Klintmalm GB, O'Leary JG, Amaral S, Goldfarb S, Rand E, Rossano JW, Kohli U, Heeger P, Stahl E, Christie JD, Fuentes MH, Levine JE, Aplenc R, Schadt EE, Stranger BE, Kluin J, Potena L, Zuckermann A, Khush K, Alzahrani AJ, Al-Muhanna FA, Al-Ali AK, Al-Ali R, Al-Rubaish AM, Al-Mueilo S, Byrne EM, Miller D, Alexander SI, Onengut-Gumuscu S, Rich SS, Suthanthiran M, Tedesco H, Saw CL, Ragoussis J, Kfoury AG, Horne B, Carlquist J, Gerstein MB, Reindl-Schwaighofer R, Oberbauer R, Wijmenga C, Palmer S, Pereira AC, Segovia J, Alonso-Pulpon LA, Comez-Bueno M, Vilches C, Jaramillo N, de Borst MH, Naesens M, Hao K, MacArthur DG, Balasubramanian S, Conlon PJ, Lord GM, Ritchie MD, Snyder M, Olthoff KM, Moore JH, Petersdorf EW, Kamoun M, Wang J, Monos DS, de Bakker PIW, Hakonarson H, Murphy B, Lankree MB, Garcia-Pavia P, Oetting WS, Birdwell KA, Bakker SJL, Israni AK, Shaked A, Asselbergs FW]] , Design and Implementation of the International Genetics and Translational Research in Transplantation Network. TRANSPLANTATION 2015;99 (11):2401-2412 [PubMed]
Bunge JJH, van Osch D, Dieleman JM, Jacob KA, Kluin J, van Dijk D, Nathoe HM [Contributors: Bredée JJ, Buhre WF, Dieleman JM, van Dijk D, van Herwerden LA, Kalkman CJ, van Klarenbosch J, Moons KG, Nathoe HM, Numan SC, Ottens TH, Roes KC, Sauer AMC, Slooter AJ, Nierich AP, Ennema JJ, Rosseel PM, van der Meer NJ, van der Maaten JM, Cernak V, Hofland J, van Thiel RJ, Diephuis JC, Schepp RM, Haenen J, de Lange F, Boer C, de Jong JR, Tijssen JG]] , Dexamethasone for the prevention of postpericardiotomy syndrome: A DExamethasone for Cardiac Surgery substudy. AM HEART J 2014;168 (1):126-31.e1 [PubMed]
Jacob KA, Nathoe HM, Dieleman JM, van Osch D, Kluin J, van Dijk D, Inflammation in new-onset atrial fibrillation after cardiac surgery: a systematic review. EUR J CLIN INVEST 2014;44 (4):402-428 [PubMed]
Jansen R, Kluin J, Chamuleau SAJ, Research Versus Clinical Practice in Asymptomatic Patients With Severe Organic Mitral Regurgitation and Preserved LV Function. J AM COLL CARDIOL 2014;64 (15):1639-1640 [PubMed]
Korteland NM, Kluin J, Klautz RJM, Roos-Hesselink JW, Versteegh MIM, Bogers AJJC, Takkenberg JJM, Cardiologist and cardiac surgeon view on decision-making in prosthetic aortic valve selection: does profession matter?. NETH HEART J 2014;22 (7-8):336-343 [PubMed]
Samim M, Agostoni P, Nijhoff F, Budde RPJ, Abrahams AC, Kluin J, Ramjankhan F, Doevendans PA, Stella PR, Three-dimensional aortic root reconstruction derived from rotational angiography for transcatheter balloon-expandable aortic valve implantation guidance. INT J CARDIOL 2014;176 (3):1318-1320 [PubMed]
Samin M, Juthier F, van Belle C, Agostoni P, Kluin J, Stella PR, Ramjankhan F, Budde RPJ, Sieswerda G, Algeri E, Elkalioubie A, Belkacemi A, Bertrand ME, Doevendans PA, van Belle E, Automated 3D Analysis of Multislice Computed Tomography to Define the Line of Perpendicularity of the Aortic Annulus and of the Implanted Valve: Benefit on Planning Transcatheter Aortic Valve Replacement. CATHETER CARDIO INTE 2014;83 (1):E119-E127 [PubMed]
van der Kaaij NP. Primary Graft Dysfunction after Lung Transplantation: An Experimental Study. S.l.: s.n.; 2014. 224p. Proefschrift Erasmus University, Erasmus MC Department-Cardiothoracic Surgery. (Promotor(s): Bogers AJJC; copromotor(s): de Bruin RWF, Kluin J)
van der Kooi AW, Rots ML, Huiskamp G, Klijn FAM, Koek HL, Kluin J, Leijten FSS, Slooter AJC, Delirium Detection Based on Monitoring of Blinks and Eye Movements. AM J GERIAT PSYCHIAT 2014;22 (12):1575-1582 [PubMed]
Boerlage-van Dijk K, Jansen R, van den Brink RBA, van Herwerden LA, Kluin J, Baan J Jr, Chamuleau SAJ, Mitralisklepinsufficiëntie: het lek te lijf: diagnostiek en behandeling. NED TIJDSCHR GENEESKD 2013;157 (41):A5693 [PubMed]
de Heer LM, Habets J, Kluin J, Stella PR, Mali WPTM, van Herwerden LA, Budde RPJ, Assessment of a transcatheter heart valve prosthesis with multidetector computed tomography: in vitro and in vivo imaging characteristics. INT J CARDIOVAS IMAG 2013;29 (3):659-668 [PubMed]
Güçlü A, Germans T, Witjas-Paalberends ER, Stienen GJM, Brouwer WP, Harms HJ, Marcus JT, Vonk ABA, Stooker W, Yilmaz A, Klein P, ten Berg JM, Kluin J, Asselbergs FW, Lammertsma AA, Knaapen P, van Rossum AC, van der Velden J, ENerGetIcs in hypertrophic cardiomyopathy: traNslation between MRI, PET and cardiac myofilament function (ENGINE study). NETH HEART J 2013;21 (12):567-571 [PubMed]
Jansen R, Kracht PAM, Cramer MJ, Tietge WJ, van Herwerden LA, Klautz RJM, Kluin J, Chamuleau SAJ, The role of exercise echocardiography in the management of mitral valve disease. NETH HEART J 2013;21 (11):487-496 [PubMed]
Nijhoff F, Agostoni P, Samim M, Ramjankhan FZ, Kluin J, Doevendans PA, Stella PR, Optimisation of transcatheter aortic balloon-expandable valve deployment: the two-step inflation technique. EUROINTERVENTION 2013;9 (5):555-563 [PubMed]
Samim M, Stella PR, Agostoni P, Kluin J, Ramjankhan F, Budde RPJ, Sieswerda G, Algeri E, van Belle C, Elkalioubie A, Juthier F, Belkacemi A, Bertrand ME, Doevendans PA, van Belle E, Automated 3D Analysis of Pre-Procedural MDCT to Predict Annulus Plane Angulation and C-Arm Positioning Benefit on Procedural Outcome in Patients Referred for TAVR. JACC-CARDIOVASC IMAG 2013;6 (2):238-248 [PubMed]
Samim M, Stella PR, Agostoni P, Kluin J, Ramjankhan F, Sieswerda G, Budde R, van der Linden M, Juthier F, Banfi C, Hurt C, Samim M, Hillaert M, van Herwerden L, Bertrand ME, Doevendans PAM, van Belle E, A prospective "oversizing'' strategy of the Edwards SAPIEN bioprosthesis: Results and impact on aortic regurgitation. J THORAC CARDIOV SUR 2013;145 (2):398-405 [PubMed]
van Belle E, Samim M, El Kalioubie A, van Belle C, Stella PR, Agostoni P, Kluin J, Ramjankhan F, Budde RPJ, Sieswerda G, Algeri E, Juthier F, Belkacemi A, Bertrand ME, Doevendans PA, MDCT in TAVR for Better Implant Angle and Outcomes REPLY. JACC-CARDIOVASC IMAG 2013;6 (8):923 [PubMed]
de Heer LM. Non-invasive imaging of the aortic root : towards optimal evaluation and sizing of stented (tissue engineered) heart valves. S.l.: s.n.; 2012. 281p. ISBN 978-94-6108-327-2 Proefschrift Universiteit Utrecht, Cardiothoracic Surgery. (Promotor(s): van Herwerden LA; copromotor(s): Kluin J, Budde RPJ)
de Heer LM, Budde RPJ, van Prehn J, Mali WPTM, Bartels LW, Stella PR, van Herwerden LA, Kluin J, Vincken KL, Pulsatile Distention of the Nondiseased and Stenotic Aortic Valve Annulus: Analysis With Electrocardiogram-Gated Computed Tomography. ANN THORAC SURG 2012;93 (2):516-522 [PubMed]
de Heer LM, Habets J, Chamuleau SAJ, Mali WPTM, van Herwerden LA, Kluin J, Budde RPJ, Multidetector Row Computed Tomography Assessment of the Native Aortic and Mitral Valve A Call for Routine Assessment of Left-Sided Heart Valves During Coronary Computed Tomography. CARDIOL REV 2012;20 (5):222-229 [PubMed]
de Heer LM, Kluin J, Stella PR, Sieswerda GTJ, Mali WPTM, van Herwerden LA, Budde RPJ, Multimodality imaging throughout transcatheter aortic valve implantation. FUTURE CARDIOL 2012;8 (3):413-424 [PubMed]
Dijkman PE, Driessen-Mol A, de Heer LM, Kluin J, van Herwerden LA, Odermatt B, Baaijens FPT, Hoerstrup SP, Trans-Apical versus Surgical Implantation of Autologous Ovine Tissue-Engineered Heart Valves. J HEART VALVE DIS 2012;21 (5):670-678 [PubMed]
Houthuizen P, van Garsse LAFM, Poels TT, de Jaegere P, van der Boon RMA, Swinkels BM, ten Berg JM, van der Kley F, Schalij MJ, Baan J Jr, Cocchieri R, Brueren GRG, van Straten AHM, den Heijer P, Bentala M, van Ommen V, Kluin J, Stella PR, Prins MH, Maessen JG, Prinzen FW, Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death. CIRCULATION 2012;126 (6):720-728 [PubMed]
Onsea K, Agostoni P, Samim M, Voskuil M, Kluin J, Budde R, Hendrikse J, Ramjankhan F, van Klarenbosch J, Doesburg P, Sieswerda G, Stella P, First-in-man experience with a new embolic deflection device in transcatheter aortic valve interventions. EUROINTERVENTION 2012;8 (1):51-56 [PubMed]
Riem Vis PW, Sluijter JPG, Soekhradj-Soechit RS, van Herwerden LA, Kluin J, Bouten CVC, Sequential use of human-derived medium supplements favours cardiovascular tissue engineering. J CELL MOL MED 2012;16 (4):730-739 [PubMed]
Riem Vis PW, van Rijswijk JW, Chamuleau SAJ, Vink A, van Herwerden LA, Kluin J, The pathophysiological basis of pharmacological interventions in CAVD. NETH HEART J 2012;20 (6):270-278 [PubMed]
Tietge WJ, de Heer LM, van Hessen MWJ, Jansen R, Bots ML, van Gilst W, Schalij M, Klautz RJM, van den Brink RBA, van Herwerden LA, Doevendans PA, Chamuleau SAJ, Kluin J, Early mitral valve repair versus watchful waiting in patients with severe asymptomatic organic mitral regurgitation; rationale and design of the Dutch AMR trial, a multicenter, randomised trial. NETH HEART J 2012;20 (3):94-101 [PubMed]
van der Kaaij NP, Kluin J, Lachmann RA, den Bakker MA, Lambrecht BN, Lachmann B, de Bruin RWF, Bogers AJJC, Alveolar preservation with high inflation pressure and intermediate oxygen concentration reduces ischemia-reperfusion injury of the lung. J HEART LUNG TRANSPL 2012;31 (5):531-537 [PubMed]
Budde RPJ, Kluin J, van Herwerden LA, Prokop M, Comprehensive Dynamic Aortic and Cardiac Analysis by 256-Slice Computed Tomography in Type A Dissection. ANN THORAC SURG 2011;92 (3):E47-E48 [PubMed]
de Heer LM, Budde RPJ, Mali WPTM, de Vos AM, van Herwerden LA, Kluin J, Aortic root dimension changes during systole and diastole: evaluation with ECG-gated multidetector row computed tomography. INT J CARDIOVAS IMAG 2011;27 (8):1195-1204 [PubMed]
de Heer LM, Budde RPJ, Vonken EJPA, Baaijens FPT, Gründeman PF, van Herwerden LA, Hoerstrup SP, Kluin J, Computed Tomography Detects Tissue Formation in a Stented Engineered Heart Valve. ANN THORAC SURG 2011;92 (1):344-345 [PubMed]
Riem Vis PW. Towards new therapies for calcific aortic valve disease: Improving heart valve tissue engineering protocols and the search for pharmacological targets. S.l.: s.n.; 2011. 216p. ISBN 978-90-393-55631-9 Proefschrift Universiteit Utrecht, Cardio-thoracic Surgery. (Promotor(s): van Herwerden LA, Bouten CVC; copromotor(s): Kluin J, Sluijter JPG)
Riem Vis PW, Kluin J, Sluijter JPG, van Herwerden LA, Bouten CVC, Environmental regulation of valvulogenesis: implications for tissue engineering. EUR J CARDIO-THORAC 2011;39 (1):8-17 [PubMed]
Samim M, Stella PR, Agostoni P, Kluin J, Ramjankhan F, Sieswerda G, Budde R, der Linden Mv, Samim M, Hillaert M, van Herwerden L, Doevendans PAM, van Belle E, Transcatheter aortic implantation of the Edwards-SAPIEN bioprosthesis: Insights on early benefit of TAVI on mitral regurgitation. INT J CARDIOL 2011;152 (1):124-126 [PubMed]
van Geemen D, Riem Vis PW, Soekhradj-Soechit S, Sluijter JPG, de Liefde-van Beest M, Kluin J, Bouten CVC, Decreased Mechanical Properties of Heart Valve Tissue Constructs Cultured in Platelet Lysate as Compared to Fetal Bovine Serum. TISSUE ENG 2011;17 (5):607-617 [PubMed]
Braithwaite S, Kluin J, Buhre WF, de Waal EEC, Anaesthesia in the cardiac catheterization laboratory. CURR OPIN ANESTHESIO 2010;23 (4):507-512 [PubMed]
Budde RPJ, Kluin J, Symersky P, Chamuleau SAJ, van Herwerden LA, Prokop M, Visualization by 256-Slice Computed Tomography of Mycotic Aortic Root Aneurysms in Infective Endocarditis. J HEART VALVE DIS 2010;19 (5):623-625 [PubMed]
Riem Vis PW, Bouten CVC, Sluijter JPG, Pasterkamp G, van Herwerden LA, Kluin J, Platelet-Lysate as an Autologous Alternative for Fetal Bovine Serum in Cardiovascular Tissue Engineering. TISSUE ENG 2010;16 (4):1317-1327 [PubMed]
Uijlings R, Kluin J, Salomonsz R, Burgmans M, Cramer MJ, Pacemaker Lead-Induced Severe Tricuspid Valve Stenosis. CIRC-HEART FAIL 2010;3 (3):465-467 [PubMed]
Hjortnaes J, Bouten CVC, van Herwerden LA, Gründeman PF, Kluin J, Translating Autologous Heart Valve Tissue Engineering from Bench to Bed. TISSUE ENG 2009;15 (3):307-317 [PubMed]
van der Kaaij NP, Kluin J, Invited commentary. ANN THORAC SURG 2009;88 (6):1743-1744 [PubMed]
van der Kaaij NP, Kluin J, Haitsma JJ, den Bakker MA, Lambrecht BN, Lachmann B, de Bruin RWF, Bogers AJJC, Surfactant pretreatment decreases long-term damage after ischemia-reperfusion injury of the lung. EUR J CARDIO-THORAC 2009;35 (2):304-312 [PubMed]
van der Kaaij NP, Kluin J, Haitsma JJ, den Bakker MA, Lambrecht BN, Lachmann B, de Bruin RWF, Bogers AJJC, Ischemia of the lung causes extensive long-term pulmonary injury: an experimental study. RESP RES 2008;9:28 [PubMed]
Boere IA, Robinson DJ, de Bruijn HS, Kluin J, Tilanus HW, Sterenborg HJCM, de Bruin RWF, Protoporphyrin IX fluorescence photobleaching and the response of rat Barrett's esophagus following 5-aminolevulinic acid photodynamic therapy. PHOTOCHEM PHOTOBIOL 2006;82 (6):1638-1644 [PubMed]
Meijboom WB, Mollet NR, van Mieghem CAG, Kluin J, Weustink AC, Pugliese F, Vourvouri E, Cademartiri F, Bogers AJJC, Krestin GP, de Feyter PJ, Pre-operative computed tomography coronary anglography to detect significant coronary artery disease in patients referred for cardiac valve surgery. J AM COLL CARDIOL 2006;48 (8):1658-1665 [PubMed]
de Kraker M, Kluin J, Renken N, Maat APWM, Bogers AJJC, CT and myasthenia gravis: correlation between mediastinal imaging and histopathological findings. INTERACT CARDIOV TH 2005;4 (3):267-271 [PubMed]
Heisterkamp J, den Hoed PT, Kluin J, Weidema WF, van Steensel CJ, Long-term results after modified Gallie technique for incisional hernia repair: results in 19 patients. HERNIA 2005;9 (1):12-15 [PubMed]
van der Kaaij NP, Haitsma JJ, Kluin J, Lambrecht BN, Lachmann B, de Bruin RWF, Bogers AJJC, Surfactant pretreatment ameliorates ischemia-reperfusion injury of the lung. EUR J CARDIO-THORAC 2005;27 (5):774-781 [PubMed]
Kluin J, den Hoed PT, van Linschoten R, IJzerman JC, van Steensel CJ, Endoscopic evaluation and treatment of groin pain in the athlete. AM J SPORT MED 2004;32 (4):944-949 [PubMed]
van den Boogert J, Hans Hoeve LJ, Struijs A, Hagenouw RRPM, Bogers AJJC, Single-stage surgical repair of benign laryngotracheal stenosis in adults. HEAD NECK-J SCI SPEC 2004;26 (2):111-117 [PubMed]
Boere IA, Robinson DJ, de Bruijn HS, van den Boogert J, Tilanus HW, Sterenborg HJ, de Bruin RW, Monitoring in Situ dosimetry and protoporphyrin IX fluorescence photobleaching in the normal rat esophagus during 5-aminolevulinic acid photodynamic therapy. PHOTOCHEM PHOTOBIOL 2003;78 (3):271-277 [PubMed]
van den Boogert J, den Hoed PT, Veen HF, Harteloh PPM, De necrologiebespreking als instrument voor kwaliteitsverbetering; ervaringen in het Ikazia Ziekenhuis, 1990-2000. NED TIJDSCHR GENEESKD 2003;147 (13):599-603 [PubMed]
van den Boogert J, van Staveren HJ, de Bruin RW, Siersema PD, van Hillegersberg R, Fractionated illumination for oesophageal ALA-PDT: Effect on blood flow and PpIX formation. LASER MED SCI 2001;16 (1):16-25 [PubMed]
van den Boogert J, van Staveren HJ, de Bruin RWF, de Rooij FWM, Edixhoven-Bosdijk A, Siersema PD, van Hillegersberg R, Fractionated illumination in oesophageal ALA-PDT: effect on ferrochelatase activity. J PHOTOCH PHOTOBIO B 2000;56 (1):53-60 [PubMed]
van den Boogert J, Houtsmuller AB, de Rooij FW, de Bruin RW, Siersema PD, van Hillegersberg R, Kinetics, localization, and mechanism of 5-aminolevulinic acid-induced porphyrin accumulation in normal and Barrett's-like rat esophagus. LASER SURG MED 1999;24 (1):3-13 [PubMed]
van den Boogert J, van Hillegersberg R, de Bruin RWF, Gastric perforation in WAG/Rij rats after esophagojejunostomy. CONTEMP TOP LAB ANIM 1999;38 (5):50-53 [PubMed]
van den Boogert J, van Hillegersberg R, Siersema PD, de Bruin RW, Tilanus HW, Endoscopic ablation therapy for Barrett's esophagus with high-grade dysplasia: A review. AM J GASTROENTEROL 1999;94 (5):1153-1160 [PubMed]
van den Boogert J, van Hillegersberg R, van Staveren HJ, de Bruin RW, van Dekken H, Siersema PD, Tilanus HW, Timing of illumination is essential for effective and safe photodynamic therapy: a study in the normal rat oesophagus. BRIT J CANCER 1999;79 (5-6):825-830 [PubMed]
van den Boogert J, van Staveren HJ, de Bruin RW, Eikelaar JH, Siersema PD, van Hillegersberg R, Photodynamic therapy for esophageal lesions: Selectivity depends on wavelength, power, and light dose. ANN THORAC SURG 1999;68 (5):1763-1769 [PubMed]
van den Boogert J, van Hillegersberg R, de Bruin RW, Tilanus HW, Siersema PD, Barrett's oesophagus: Pathophysiology, diagnosis, and management. SCAND J GASTROENTERO 1998;33 (5):449-453 [PubMed]
van den Boogert J, van Hillegersberg R, de Rooij FW, de Bruin RW, Edixhoven-Bosdijk A, Houtsmuller AB, Siersema PD, Wilson JH, Tilanus HW, 5-aminolaevulinic acid-induced protoporphyrin IX accumulation in tissues: pharmacokinetics after oral or intravenous administration. J PHOTOCH PHOTOBIO B 1998;44 (1):29-38 [PubMed]
Henry MC, Eggelte TA, Watson P, Docters van Leeuwen B, Bakker DA, Kluin J, Response of childhood malaria to chloroquine and Fansidar in an area of intermediate chloroquine resistance in Côte d'Ivoire. TROP MED INT HEALTH 1996;1 (5):610-615 [PubMed]
Key publications

Kluin J, Talacua H , Smits AIPM, Emmert MY, Brugmans MCP, Fioretta ES, Dijkman PE, Söntjens SHM, Duijvelshoff R, Dekker S, Janssen-van den Broek MWJT, Lintas V, Vink A, Hoerstrup SP, Janssen HM, Dankers PYW, Baaijens FPT, Bouten CVC, In situ heart valve tissue engineering using a bioresorbable elastomeric implant - From material design to 12 months follow-up in sheep. BIOMATERIALS 2017;125:101-117 [PubMed]
de Heer LM, Budde RPJ, Mali WPTM, de Vos AM, van Herwerden LA, Kluin J, Aortic root dimension changes during systole and diastole: evaluation with ECG-gated multidetector row computed tomography. INT J CARDIOVAS IMAG 2011;27 (8):1195-1204 [PubMed]
Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J, Aikawa E, Valvular interstitial cells suppress calcification of valvular endothelial cells. ATHEROSCLEROSIS 2015;242 (1):251-260 [PubMed]
Houthuizen P, van Garsse LAFM, Poels TT, de Jaegere P, van der Boon RMA, Swinkels BM, ten Berg JM, van der Kley F, Schalij MJ, Baan J Jr, Cocchieri R, Brueren GRG, van Straten AHM, den Heijer P, Bentala M, van Ommen V, Kluin J, Stella PR, Prins MH, Maessen JG, Prinzen FW, Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death. CIRCULATION 2012;126 (6):720-728 [PubMed]
Onsea K, Agostoni P, Samim M, Voskuil M, Kluin J, Budde R, Hendrikse J, Ramjankhan F, van Klarenbosch J, Doesburg P, Sieswerda G, Stella P, First-in-man experience with a new embolic deflection device in transcatheter aortic valve interventions. EUROINTERVENTION 2012;8 (1):51-56 [PubMed]


All Publications

Research programmes

Translational research in cardio-thoracic surgery and the application of regenerative medicine technologies

- heart valve tissue engineering

- aortic valve homeostasis and pathology

- hybrid heart development

- imaging

Faculty
Dr. J. Kluin MD PhD

PhD Students
E.S. Farag
F. de Heer
J.W. van Rijswijk
Drs. M. Uiterwijk MD (UMCU / TUeindhoven)
R. Janssen MD (UMC Utrecht)

Other research related activities
  • None reported
Current research funding
  • AMC
  • Europese Unie
  • Nederlandse Hartstichting
  • Stichting AMC Foundation (Vrijgesteld)