• Principal Investigator
  • Female

Dr. A.M.M. van Pelt PhD

Position: Associate professor (UHD)
Main activities: Research
Specialisation: Research
foto A.M.M. van Pelt is one of the AMC Principal Investigators
Focus of research:

Spermatogenesis and Stem Cells

 

AMC themes: Reproduction and development
Departments: Center for Reproductive Medicine
Beaud H, van Pelt A, Delbes G, Doxorubicin and vincristine affect undifferentiated rat spermatogonia. REPRODUCTION 2017;153 (6):725-735 [PubMed]
Gopinathan L, Szmyd R, Low D, Diril MK, Chang HY, Coppola V, Liu K, Tessarollo L, Guccione E, van Pelt AMM, Kaldis P, Emi2 Is Essential for Mouse Spermatogenesis. CELL REP 2017;20 (3):697-708 [PubMed]
Jan SZ, Vormer TL, Jongejan A, Röling M, Silber SJ, de rooij DG , Hamer G, Repping S, van Pelt AMM, Unraveling transcriptome dynamics in human spermatogenesis. DEVELOPMENT 2017;ahead of print [PubMed]
Poganitsch-Korhonen M, Masliukaite I, Nurmio M, Lähteenmäki P, van Wely M, van Pelt AMM, Jahnukainen K, Stukenborg JB, Decreased spermatogonial quantity in prepubertal boys with leukaemia treated with alkylating agents. LEUKEMIA 2017;31 (6):1460-1463 [PubMed]
Serrano JB, Martins F, Sousa JC, Pereira CD, van Pelt AMM, Rebelo S, da Cruz E Silva OAB, Descriptive Analysis of LAP1 Distribution and That of Associated Proteins throughout Spermatogenesis. MEMBRANES (BASEL) 2017;7 (2):e22 [PubMed]
Uijldert M, Meißner A, de Melker AA , van Pelt AMM, van de Wetering MD, van Rijn RR, van Wely M, van der Veen F, Repping S, Development of the testis in pre-pubertal boys with cancer after biopsy for fertility preservation. HUM REPROD 2017;ahead of print [PubMed]
Masliukaite I, Hagen JM, Jahnukainen K, Stukenborg JB, Repping S, van der Veen F, van Wely M, van Pelt AMM, Establishing reference values for age-related spermatogonial quantity in prepubertal human testes: a systematic review and meta-analysis. FERTIL STERIL 2016;106 (7):1652-1657.e2 [PubMed]
Mulder CL, Zheng Y, Jan SZ, Struijk RB, Repping S, Hamer G, van Pelt AMM, Spermatogonial stem cell autotransplantation and germline genomic editing: a future cure for spermatogenic failure and prevention of transmission of genomic diseases. HUM REPROD UPDATE 2016;22 (5):561-573 [PubMed]
Baert Y, Braye A, Struijk RB, van Pelt AMM, Goossens E, Cryopreservation of testicular tissue before long-term testicular cell culture does not alter in vitro cell dynamics. FERTIL STERIL 2015;104 (5):1244-52.e1-4 [PubMed]
de Rooij SR, van Pelt AMM, Ozanne SE, Korver CM, van Daalen SKM, Painter RC, Schwab M, Viegas MH, Roseboom TJ, Prenatal undernutrition and leukocyte telomere length in late adulthood: the Dutch famine birth cohort study. AM J CLIN NUTR 2015;102 (3):655-660 [PubMed]
Hendriks S, Dancet EAF, van Pelt AMM, Hamer G, Repping S, Artificial gametes: a systematic review of biological progress towards clinical application. HUM REPROD UPDATE 2015;21 (3):285-296 [PubMed]
Joustra SD, Meijer OC, Heinen CA, Mol IM, Laghmani EH, Sengers RMA, Carreno G, van Trotsenburg ASP, Biermasz NR, Bernard DJ, Wit JM, Oostdijk W, van Pelt AMM, Hamer G, Wagenaar GTM, Spatial and temporal expression of immunoglobulin superfamily member 1 in the rat. J ENDOCRINOL 2015;226 (3):181-191 [PubMed]
Nickkholgh B. Genetic causes and treatment of spermatogenic failure. S.l.: s.n.; 2015. 133p. ISBN 978-1-4951-5840-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Repping S; copromotor(s): van Pelt AMM)
Nickkholgh B, Korver CM, van Daalen SKM, van Pelt AMM, Repping S, AZFc deletions do not affect the function of human spermatogonia in vitro. MOL HUM REPROD 2015;21 (7):553-562 [PubMed]
Picton HM, Wyns C, Anderson RA, Goossens E, Jahnukainen K, Kliesch S, Mitchell RT, Pennings G, Rives N, Tournaye H, van Pelt AMM, Eichenlaub-Ritter U, Schlatt S, A European perspective on testicular tissue cryopreservation for fertility preservation in prepubertal and adolescent boys. HUM REPROD 2015;30 (11):2463-2475 [PubMed]
Vassena R, Eguizabal C, Heindryckx B, Sermon K, Simon C, van Pelt AMM, Veiga A, Zambelli F, Stem cells in reproductive medicine: ready for the patient?. HUM REPROD 2015;30 (9):2014-2021 [PubMed]
Chikhovskaya JV, van Daalen SKM, Korver CM, Repping S, van Pelt AMM, Mesenchymal origin of multipotent human testis-derived stem cells in human testicular cell cultures. MOL HUM REPROD 2014;20 (2):155-167 [PubMed]
Correia S, Alves MG, Oliveira PF, Alves MR, van Pelt AMM, Cavaco JE, Socorro S, Transgenic overexpression of regucalcin leads to suppression of thapsigargin- and actinomycin D-induced apoptosis in the testis by modulation of apoptotic pathways. ANDROLOGY-US 2014;2 (2):290-298 [PubMed]
Nickkholgh B, Mizrak SC, Korver CM, van Daalen SKM, Meissner A, Repping S, van Pelt AMM, Enrichment of spermatogonial stem cells from long-term cultured human testicular cells. FERTIL STERIL 2014;102 (2):558-565.e5 [PubMed]
Nickkholgh B, Mizrak SC, van Daalen SKM, Korver CM, Sadri-Ardekani H, Repping S, van Pelt AMM, Genetic and epigenetic stability of human spermatogonial stem cells during long-term culture. FERTIL STERIL 2014;102 (6):1700-7.e1 [PubMed]
Sadri-Ardekani H, Homburg CH, van Capel TMM, van den Berg H, van der Veen F, van der Schoot CE, van Pelt AMM, Repping S, Eliminating acute lymphoblastic leukemia cells from human testicular cell cultures: a pilot study. FERTIL STERIL 2014;101 (4):1072-1078.e1 [PubMed]
Visser L. Genetic studies in spermatogenic failure. S.l.: s.n.; 2014. 223p. ISBN 9789082284904 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Repping S, van der Veen F; copromotor(s): van Pelt AMM)
Chikhovskaya JV. The potency of human testicular stem cells. s.l.: s.n.; 2013. 166p. ISBN 0789461085283 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Repping S; copromotor(s): van Pelt AMM)
Struijk RB, Mulder CL, van der Veen F, van Pelt AMM, Repping S, Restoring fertility in sterile childhood cancer survivors by autotransplanting spermatogonial stem cells: are we there yet?. BIOMED RES INT 2013;2013:903142 [PubMed]
Verver DE, van Pelt AMM, Repping S, Hamer G, Role for rodent Smc6 in pericentromeric heterochromatin domains during spermatogonial differentiation and meiosis. CELL DEATH DIS 2013;4:e749 [PubMed]
Besouw MTP, van Pelt AMM, Gaide Chevronnay HP, Courtoy PJ, Pastore A, Goossens E, Devuyst O, Antignac C, Levtchenko EN, Studying nonobstructive azoospermia in cystinosis: histologic examination of testes and epididymis and sperm analysis in a Ctns(-/-) mouse model. FERTIL STERIL 2012;98 (1):162-165 [PubMed]
Chikhovskaya JV, Jonker MJ, Meissner A, Breit TM, Repping S, van Pelt AMM, Human testis-derived embryonic stem cell-like cells are not pluripotent, but possess potential of mesenchymal progenitors. HUM REPROD 2012;27 (1):210-221 [PubMed]
Jan SZ, Hamer G, Repping S, de Rooij DG, van Pelt AMM, Vormer TL, Molecular control of rodent spermatogenesis. BBA-MOL BASIS DIS 2012;1822 (12):1838-1850 [PubMed]
Noordam MJ. The Y chromome: a sole survivor. s.l.: s.n.; 2012. 153p. ISBN 9789088914072 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Repping S, van der Veen F; copromotor(s): van Pelt AMM)
Carlomagno G. Factors driving spermatogonial stem cell fate. s.l.: s.n.; 2011. 124p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Repping S; copromotor(s): van Pelt AMM)
Mizrak SC, Gadella BM, Erdost H, Ozer A, van Pelt AMM, van Dissel-Emiliani FMF, Correction: Spermatogonial stem cell sensitivity to capsaicin: An in vitro study. REPROD BIOL ENDOCRIN 2011;9 (1):17 [PubMed]
Noordam MJ, Westerveld GH, Hovingh SE, van Daalen SKM, Korver CM, van der Veen F, van Pelt AMM, Repping S, Gene copy number reduction in the azoospermia factor c (AZFc) region and its effect on total motile sperm count. HUM MOL GENET 2011;20 (12):2457-2463 [PubMed]
Sadri-Ardekani H. Spermatogonial stem cell autotransplantation. Towards clinical application’. s.l.: s.n.; 2011. -p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Repping S, van der Veen F; copromotor(s): van Pelt AMM)
Sadri-Ardekani H, Akhondi MA, van der Veen F, Repping S, van Pelt AMM, In Vitro Propagation of Human Prepubertal Spermatogonial Stem Cells. JAMA-J AM MED ASSOC 2011;305 (23):2416-2418 [PubMed]
Carlomagno G, van Bragt MPA, Korver CM, Repping S, de Rooij DG, van Pelt AMM, BMP4-Induced Differentiation of a Rat Spermatogonial Stem Cell Line Causes Changes in Its Cell Adhesion Properties. BIOL REPROD 2010;83 (5):742-749 [PubMed]
Kuijk EW, de Gier J, Lopes SMCDS, Chambers I, van Pelt AMM, Colenbrander B, Roelen BAJ, A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis. PLOS ONE 2010;5 (6):e10987 [PubMed]
Mizrak SC , Chikhovskaya JV, Sadri-Ardekani H, van Daalen S, Korver CM, Hovingh SE, Roepers-Gajadien HL, Raya A, Fluiter K, de Reijke TM, de la Rosette JJMCH, Knegt AC, Belmonte JC, van der Veen F, de rooij DG , Repping S, van Pelt AMM, Embryonic stem cell-like cells derived from adult human testis. HUM REPROD 2010;25 (1):158-167 [PubMed]
Nickkholgh B, Noordam MJ, Hovingh SE, van Pelt AMM, van der Veen F, Repping S, Y chromosome TSPY copy numbers and semen quality. FERTIL STERIL 2010;94 (5):1744-1747 [PubMed]
Sadri-Ardekani H, Mizrak SC , van Daalen SKM, Korver CM, Roepers-Gajadien HL, Koruji M, Hovingh S, de Reijke TM, de la Rosette JJMCH, van der Veen F, de rooij DG , Repping S, van Pelt AMM, Propagation of Human Spermatogonial Stem Cells In Vitro (vol 302, pg 2127, 2009). JAMA-J AM MED ASSOC 2010;303 (5):422
Ahmed EA, Barten-van Rijbroek AD, Kal HB, Sadri-Ardekani H, Mizrak SC, van Pelt AMM, de Rooij DG, Proliferative activity in vitro and DNA repair indicate that adult mouse and human Sertoli cells are not terminally differentiated, quiescent cells. BIOL REPROD 2009;80 (6):1084-1091 [PubMed]
Sadri-Ardekani H, Mizrak SC, van Daalen SKM, Korver CM, Roepers-Gajadien HL, Koruji M, Hovingh S, de Reijke TM, de La Rosette JJMCH, van der Veen F, de Rooij DG, Repping S, van Pelt AMM, Propagation of Human Spermatogonial Stem Cells In Vitro. JAMA-J AM MED ASSOC 2009;302 (19):2127-2134 [PubMed]
Anderson EL, Baltus AE, Roepers-Gajadien HL, Hassold TJ, de Rooij DG, van Pelt AMM, Page DC, Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice. P NATL ACAD SCI USA 2008;105 (39):14976-14980 [PubMed]
de Rooij DG, Repping S, van Pelt AMM, Role for Adhesion Molecules in the Spermatogonial Stem Cell Niche. CELL STEM CELL 2008;3 (5):467-468 [PubMed]
Mizrak SC, Gadella BM, Erdost H, Ozer A, van Pelt AMM, van Dissel-Emiliani FMF, Spermatogonial stem cell sensitivity to capsaicin: an in vitro study. REPROD BIOL ENDOCRIN 2008;6:52 [PubMed]
van Bragt M. Genes involved in spermatogonial stem cell self- renewal and differentiation. Utrecht: s.n.; 2008. -p. Proefschrift Universiteit van Utrecht, Gynaecologie en Verloskunde. (Promotor(s): de rooij DG; copromotor(s): van Pelt AMM)
van Bragt MPA, Roepers-Gajadien HL, Korver CM, Bogerd J, Okuda A, Eggen BJL, de Rooij DG, van Pelt AMM, Expression of the pluripotency marker UTF1 is restricted to a subpopulation of early A spermatogonia in rat testis. REPRODUCTION 2008;136 (1):33-40 [PubMed]
Westerveld GH, Korver CM, van Pelt AMM, Leschot NJ, van der Veen F, Repping S, Lombardi MP, Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure. HUM REPROD 2006;21 (12):3178-3184 [PubMed]
Aponte PM, van Bragt MPA, de Rooij DG, van Pelt AMM, Spermatogonial stem cells: characteristics and experimental possibilities. APMIS 2005;113 (11-12):727-742 [PubMed]
Goriely A, McVean GAT, van Pelt AMM, O'Rourke AW, Wall SA, de Rooij DG, Wilkie AOM, Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogonia. P NATL ACAD SCI USA 2005;102 (17):6051-6056 [PubMed]
van Bragt MPA, Ciliberti N, Stanford WL, de Rooij DG, van Pelt AMM, LY6A/E (SCA-1) expression in the mouse testis. BIOL REPROD 2005;73 (4):634-638 [PubMed]
van den Ham R, van Dissel-Emiliani FMF, van Pelt AMM, Expression of the scaffolding subunit A of protein phosphatase 2A during rat testicular development. BIOL REPROD 2003;68 (4):1369-1375 [PubMed]
Creemers LB, den Ouden K, van Pelt AMM, de rooij DG, Maintenance of adult mouse type A spermatogonia in vitro: influence of serum and growth factors and comparison with prepubertal spermatogonial cell culture. REPRODUCTION 2002;124 (6):791-799 [PubMed]
Creemers LB, Meng X, den Ouden K, van Pelt AMM, Izadyar F, Santoro M, Sariola H, de rooij DG, Transplantation of germ cells from glial cell line-derived neurotrophic factor-overexpressing mice to host testes depleted of endogenous spermatogenesis by fractionated irradiation. BIOL REPROD 2002;66 (6):1579-1584 [PubMed]
van Pelt AMM, Roepers-Gajadien HL, Gademan IS, Creemers LB, de Rooij DG, van Dissel-Emiliani FMF, Establishment of cell lines with rat spermatogonial stem cell characteristics. ENDOCRINOLOGY 2002;143 (5):1845-1850 [PubMed]
Izadyar F, Creemers LB, van Dissel-Emiliani FM, van Pelt AM, de rooij DG, Spermatogonial stem cell transplantation. MOL CELL ENDOCRINOL 2000;169 (1-2):21-26 [PubMed]
Schrans-Stassen BH, van de Kant HJ, de rooij DG , van Pelt AM, Differential expression of c-kit in mouse undifferentiated and differentiating type A spermatogonia. ENDOCRINOLOGY 1999;140 (12):5894-5900 [PubMed]
van Pelt AM, de rooij DG , van der Burg B, van der Saag PT, Gustafsson JA, Kuiper GG, Ontogeny of estrogen receptor-beta expression in rat testis. ENDOCRINOLOGY 1999;140 (1):478-483 [PubMed]
Gaemers IC, Sonneveld E, van Pelt AM, Schrans BH, Themmen AP, van der Saag PT, de rooij DG, The effect of 9-cis-retinoic acid on proliferation and differentiation of a spermatogonia and retinoid receptor gene expression in the vitamin A-deficient mouse testis. ENDOCRINOLOGY 1998;139 (10):4269-4276 [PubMed]
Gaemers IC, van Pelt AM, Themmen AP, de rooij DG, Isolation and characterization of all-trans-retinoic acid-responsive genes in the rat testis. MOL REPROD DEV 1998;50 (1):1-6 [PubMed]
Gaemers IC, van Pelt AM, van der Saag PT, Hoogerbrugge JW, Themmen AP, de rooij DG, Differential expression pattern of retinoid X receptors in adult murine testicular cells implies varying roles for these receptors in spermatogenesis. BIOL REPROD 1998;58 (6):1351-1356 [PubMed]
Gaemers IC, van Pelt AM, van der Saag PT, Hoogerbrugge JW, Themmen AP, de rooij DG, Effect of retinoid status on the messenger ribonucleic acid expression of nuclear retinoid receptors alpha, beta, and gamma, and retinoid X receptors alpha, beta, and gamma in the mouse testis. ENDOCRINOLOGY 1997;138 (4):1544-1551 [PubMed]
van den Ham R, van Pelt AM, de Miguel MP, van Kooten PJ, Walther N, van Dissel-Emiliani FM, Immunomagnetic isolation of fetal rat gonocytes. AM J REPROD IMMUNOL 1997;38 (1):39-45 [PubMed]
Gaemers IC, van Pelt AM, van der Saag PT, de rooij DG, All-trans-4-oxo-retinoic acid: a potent inducer of in vivo proliferation of growth-arrested A spermatogonia in the vitamin A-deficient mouse testis. ENDOCRINOLOGY 1996;137 (2):479-485 [PubMed]
Richters CD, Reits EA, van Pelt AM, Hoekstra MJ, van Baare J, Du Pont JS, Kamperdijk EW, Effect of low dose UVB irradiation on the migratory properties and functional capacities of human skin dendritic cells. CLIN EXP IMMUNOL 1996;104 (1):191-197 [PubMed]
van Pelt AM, Morena AR, van Dissel-Emiliani FM, Boitani C, Gaemers IC, de rooij DG , Stefanini M, Isolation of the synchronized A spermatogonia from adult vitamin A-deficient rat testes. BIOL REPROD 1996;55 (2):439-444 [PubMed]
van Pelt AM, van Dissel-Emiliani FM, Gaemers IC, van der Burg MJ, Tanke HJ, de rooij DG, Characteristics of A spermatogonia and preleptotene spermatocytes in the vitamin A-deficient rat testis. BIOL REPROD 1995;53 (3):570-578 [PubMed]
Klaij IA, van Pelt AM, Timmerman MA, Blok LJ, de rooij DG , de Jong FH, Expression of inhibin subunit mRNAs and inhibin levels in the testes of rats with stage-synchronized spermatogenesis. J ENDOCRINOL 1994;141 (1):131-141 [PubMed]
van Pelt AM, van den Brink CE, de rooij DG , van der Saag PT, Changes in retinoic acid receptor messenger ribonucleic acid levels in the vitamin A-deficient rat testis after administration of retinoids. ENDOCRINOLOGY 1992;131 (1):344-340 [PubMed]
van der Grond J, van Pelt AM, van Echteld CJ, Dijkstra G, Grootegoed JA, de rooij DG , Mali WP, Characterization of the testicular cell types present in the rat by in vivo 31P magnetic resonance spectroscopy. BIOL REPROD 1991;45 (1):122-127 [PubMed]
van Pelt AM, de rooij DG, Retinoic acid is able to reinitiate spermatogenesis in vitamin A-deficient rats and high replicate doses support the full development of spermatogenic cells. ENDOCRINOLOGY 1991;128 (2):697-704 [PubMed]
van de Kant HJ, van Pelt AM, Vergouwen RP, de rooij DG, A rapid immunogold-silver staining for detection of bromodeoxyuridine in large numbers of plastic sections, using microwave irradiation. HISTOCHEM J 1990;22 (6-7):321-326 [PubMed]
van Pelt AM, de rooij DG, Synchronization of the seminiferous epithelium after vitamin A replacement in vitamin A-deficient mice. BIOL REPROD 1990;43 (3):363-367 [PubMed]
van Pelt AM, de rooij DG, The origin of the synchronization of the seminiferous epithelium in vitamin A-deficient rats after vitamin A replacement. BIOL REPROD 1990;42 (4):677-682 [PubMed]
de rooij DG , van Dissel-Emiliani FM, van Pelt AM, Regulation of spermatogonial proliferation. ANN NY ACAD SCI 1989;564:140-153 [PubMed]
Key publications

Jan SZ, Vormer TL, Jongejan A, Röling M, Silber SJ, de rooij DG , Hamer G, Repping S, van Pelt AMM, Unraveling transcriptome dynamics in human spermatogenesis. DEVELOPMENT 2017;ahead of print [PubMed]
Mulder CL, Zheng Y, Jan SZ, Struijk RB, Repping S, Hamer G, van Pelt AMM, Spermatogonial stem cell autotransplantation and germline genomic editing: a future cure for spermatogenic failure and prevention of transmission of genomic diseases. HUM REPROD UPDATE 2016;22 (5):561-573 [PubMed]
Nickkholgh B, Mizrak SC, van Daalen SKM, Korver CM, Sadri-Ardekani H, Repping S, van Pelt AMM, Genetic and epigenetic stability of human spermatogonial stem cells during long-term culture. FERTIL STERIL 2014;102 (6):1700-7.e1 [PubMed]
Chikhovskaya JV, Jonker MJ, Meissner A, Breit TM, Repping S, van Pelt AMM, Human testis-derived embryonic stem cell-like cells are not pluripotent, but possess potential of mesenchymal progenitors. HUM REPROD 2012;27 (1):210-221 [PubMed]
Sadri-Ardekani H, Akhondi MA, van der Veen F, Repping S, van Pelt AMM, In Vitro Propagation of Human Prepubertal Spermatogonial Stem Cells. JAMA-J AM MED ASSOC 2011;305 (23):2416-2418 [PubMed]


All Publications

Curriculum Vitae

 
Education: Biology, University Utrecht

 PhD degree: March 1992, Thesis: The role of retinoids in spermatogenesis

Career:
Nov 2012  - onwards             Associate Professor (PI) Laboratory for Reproductive Biology, Center for Reproductive Medicine, AMC, Amsterdam, The Netherlands
Apr 2007   - Nov 2012           Senior researcher/Assistant Professor Laboratory for Reproductive Biology, Center for Reproductive Medicine, AMC, Amsterdam, The Netherlands
Feb 2001  - Apr 2007            Assistant Professor Department of Endocrinology, Faculty of Science, UU, Utrecht, The Netherlands
Apr 1992   - Feb 2001           Post-doc positions UMCU, Utrecht, The Netherlands
Oct 1996   - Jan 1997           University Teacher Veterinary School, UU, Utrecht, The Netherlands

Other tasks

Febr 2016 – onwards        Member of the (AMC) EU support group
April 2013                          Organizer of the annual meeting of the Dutch Society of Stem Cell Research (DSSCR)
Jan 2012 - onwards           Secretary and Member of the Board of the Dutch Society of Stem Cell Research (DSSCR)
July 2011 - onwards           Member of the Board of Reviewing Editors of scientific journal: ‘Biology of Reproduction’ 2011
June 2011- onwards          Member of ESHRE Fertility Preservation Task Force Subgroup II: Fertility preservation for boys and men
Jan 2011 - onwards           Member of the international review committee of the German Research Foundation (Deutsche Forschungsgemeinschaft) for the evaluation of research unit FOR 1041/2
Jan 2010 - onwards           Member of the Editorial board of a new Scientific Journal “Spermatogenesis”
May 2010 - onwards          Member of European Society for Human Reproduction and Embryology (ESHRE)
May 2008 - onwards          Member of the Dutch Society for Stem Cell Research (DSSCR)
March 2007-onwards         Member of the International Society for In Vitro Methods (INVITROM)
Oct 2000 - Febr 2005         Assistant coordinator of the EC program QLK-2000-00305
Oct 1994 - dec 1997          Secretary of the Dutch/Belgium meetings “Retinoids and Development”
 

Grants:

FCT SR&TD SFRH/BPD/104820/2014: Effect of endocrine disruptors on spermatogenesis and testicular cancer: where does the protective role of regucalcin fit in? (Post Doc fellow Sara Carina Lima Correia) (2015-2018)

Marie Curie FP7-PEOPLE-2013-ITN 603568: Development of in vitro and in vivo strategies to avoid and cure male infertility (2014-2018) (coordinator & PI)

ZonMW TAS 116003002: Spermatogonial stem cell transplantation to restore fertility in childhood cancer survivors. (2014-2022)  (PI)

KiKa 86 Restoring fertility in infertile childhood cancer survivors: bringing autotransplantation of human spermatogonial stem cells to the clinic. (2012-2014)  (PI)

FCT SR&TD SFRH/BD/60945/2009: Regucalcin, a new sex steroid target gene and an apoptosis regulator in spermatogenesis? (PhD fellow Sara Carina Lima Correia) (2009-2014)

KIKA  Autotransplantation of spermatogonial stem cells: preserving reproductive potential in childhood cancer patients. (2008-2012)  (PI)

European Science Foundation (EuroSTELLS) Translational stem cell research: from basic biology to regenerative medicine. (04-ESTELLS-F01-029 )(2005-2008)  (PI)

ZON/MW (Proefdieren Begrensd) Development of in vitro test strategies for reproductive toxicity on male germ cell lines. (3170.0067) (2004-2007)  (PI)

EU (Quality of Life and Management of Living Resources)  The impact of developmental exposure to weak (environmental) estrogens on the incidence of diseases in target organs later in life. (QLK-2000-00305) (2001-2005) (Assistant Coordinator & PI)

NIH (USA)  In vitro development of undifferentiated spermatogonia. (HD 36476) (1999-2002) (co-PI)

Platform Alternatieven voor Dierproeven (ZON) The establishment of spermatogonial stem cell lines.(96-38) (1997-2001)(PI)

NWO-MW The regulation of proliferation and differentiation of spermatogonia and the role of vitamin A. (903-44-101) (1992-1996)

 

PhD students

Completed
R van den Ham                     Dec 2000
M.P.A. van Bragt                   June 2008
G. Carlomagno                     January 2011
H. Sadri-Ardekani                 December 2011
M. Noordam                          May 2012
J. Chikhovskaya                    November 2013
L. Visser                                November 2014
S.C. de Lima Correia             December 2014
B. Nick Kholgh                      June 2015  


ongoing
S.Z. Jan
R. Struijk
C.L. Mulder
J. Eliveld
I. Masliukaite
J.M.D. Portela
J.A. Onofre
J.M. Serrano

 

Post Docs

completed
S.C. Mizrak 2007-2012
T. Vormer 2009-2013

Ongoing
S.C. de Lima Correia 2015- now
 

 

Research programmes

Human Reproductive Biology

Spermatogenesis & Stem Cells: We aim to unravel the mechanism of spermatogonial stem cell renewal and differentiation up to sperm and use this knowledge to understand spermatogenic failure in men. We aim to develop a clinical application of human SSC autotransplantation as a way to preserve reproductive potential for instance in young boys diagnosed with cancer.

 

Faculty
Dr. A.M.M. van Pelt PhD

Postdocs
S.C. de Lima Correia PhD (CICS-UBI, Covilhã, Portugal)
Dr. S.C. Mizrak MD PhD
T.L. Vormer PhD

PhD Students
J. Eliveld MSc
S.Z. Jan MSc
I. Masliukaite MSc
J.A. Meza
C.L. Mulder MSc
J.M.D. Portela MSc
J.M. Serrano
R.B. Struijk MSc

Others
A.E. Catsburg BSc
S.K.M. van Daalen BSc
C.M. Korver BSc

Prof. dr. S. Repping (Reproduction & Development -- Human Reproduction)

Prof. dr. F. van der Veen (Reproduction and development])

Other research related activities
  • Membership of advisory board / Consultant, The international visitation review committee of the German Research Foundation (Deutsche Forschungsgemeinschaft)
  • Secretary, Dutch Society for Stem Cell Research
  • Membership of medical or scientific committee, ESHRE, Fertility Preservation Task Force Subgroup II: Fertility preservation for boys and men
Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • Europese Unie
  • ZonMw