• Principal Investigator
  • Male

Prof. J.J.P. Kastelein MD PhD

Position: Professor
Main activities: Research, Teaching
Specialisation: Vascular Medicine and lipoprotein metabolism
foto J.J.P. Kastelein is one of the AMC Principal Investigators
Focus of research:
  • Pathogenesis of atherosclerosis
  • Treatment of increased cardiovascular risk
AMC themes: Cardiovascular Diseases
Departments: Internal Medicine: Vascular Medicine
Andrews J, Janssan A, Nguyen T, Pisaniello AD, Scherer DJ, Kastelein JJP, Merkely B, Nissen SE, Ray K, Schwartz GG, Worthley SG, Keyserling C, Dasseux JL, Butters J, Girardi J, Miller R, Nicholls SJ, Effect of serial infusions of reconstituted high-density lipoprotein (CER-001) on coronary atherosclerosis: rationale and design of the CARAT study. CARDIOVASC DIAGN THE 2017;7 (1):45-51 [PubMed]
Bangalore S, Fayyad R, Messerli FH, Laskey R, Demicco DA, Kastelein JJP, Waters DD, Relation of Variability of Low-Density Lipoprotein Cholesterol and Blood Pressure to Events in Patients With Previous Myocardial Infarction from the IDEAL Trial. AM J CARDIOL 2017;119 (3):379-387 [PubMed]
Besseling J, Reitsma JB, Gaudet D, Brisson D, Kastelein JJP, Hovingh GK, Hutten BA, Selection of individuals for genetic testing for familial hypercholesterolaemia: development and external validation of a prediction model for the presence of a mutation causing familial hypercholesterolaemia. EUR HEART J 2017;38 (8):565 [PubMed]
Braamskamp MJAM, Langslet G, McCrindle BW, Cassiman D, Francis GA, Gagne C, Gaudet D, Morrison KM, Wiegman A, Turner T, Miller E, Kusters DM, Raichlen JS, Martin PD, Stein EA, Kastelein JJP, Hutten BA, Effect of Rosuvastatin on Carotid Intima-Media Thickness in Children With Heterozygous Familial Hypercholesterolemia: The CHARON Study (Hypercholesterolemia in Children and Adolescents Taking Rosuvastatin Open Label). CIRCULATION 2017;136 (4):359-366 [PubMed]
Bruikman CS, Hovingh GK, Kastelein JJP, Molecular basis of familial hypercholesterolemia. CURR OPIN CARDIOL 2017;32 (3):262-266 [PubMed]
Bruikman CS, Stoekenbroek RM, Hovingh GK, Kastelein JP, New Drugs for Atherosclerosis. CAN J CARDIOL 2017;33 (3):350-357 [PubMed]
Cupido AJ, Reeskamp LF, Kastelein JJP, Novel lipid modifying drugs to lower LDL cholesterol. CURR OPIN LIPIDOL 2017;28 (4):367-373 [PubMed]
Ference BA, Kastelein JJP, Ginsberg HN, Chapman MJ, Nicholls SJ, Ray KK, Packard CJ, Laufs U, Brook RD, Oliver-Williams C, Butterworth AS, Danesh J, Smith GD, Catapano AL, Sabatine MS, Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk. JAMA-J AM MED ASSOC 2017;318 (10):947-956 [PubMed]
Kastelein JJP, Hovingh GK, Langslet G, Baccara-Dinet MT, Gipe DA, Chaudhari U, Zhao J, Minini P, Farnier M, Efficacy and safety of the proprotein convertase subtilisin/kexin type 9 monoclonal antibody alirocumab vs placebo in patients with heterozygous familial hypercholesterolemia. J CLIN LIPIDOL 2017;11 (1):195-203 [PubMed]
Kastelein JJP, Kereiakes DJ, Cannon CP, Bays HE, Minini P, Lee LV, Maroni J, Farnier M, Effect of alirocumab dose increase on LDL lowering and lipid goal attainment in patients with dyslipidemia. CORONARY ARTERY DIS 2017;28 (3):190-197 [PubMed]
Ray KK, Kastelein JJP, Time to change the SCORE?. EUR HEART J 2017;38 (8):595-597 [PubMed]
Ray KK, Landmesser U, Leiter LA, Kallend D, Dufour R, Karakas M, Hall T, Troquay RPT, Turner T, Visseren FLJ, Wijngaard P, Wright RS, Kastelein JJP, Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol. NEW ENGL J MED 2017;376 (15):1430-1440 [PubMed]
Ridker PM, Everett BM, Thuren T, Macfadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Vida-Simiti L, Flather M, Shimokawa H, Ogawa H, Dellborg M, Rossi PRF, Troquay RPT, Libby P, Glynn RJ, Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease. NEW ENGL J MED 2017;ahead of print [PubMed]
Ridker PM, Revkin J, Amarenco P, Brunell R, Curto M, Civeira F, Flather M, Glynn RJ, Gregoire J, Jukema JW, Karpov Y, Kastelein JJP, Koenig W, Lorenzatti A, Manga P, Masiukiewicz U, Miller M, Mosterd A, Murin J, Nicolau JC, Nissen S, Ponikowski P, Santos RD, Schwartz PF, Soran H, White H, Wright RS, Vrablik M, Yunis C, Shear CL, Tardif JC, Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients. NEW ENGL J MED 2017;376 (16):1527-1539 [PubMed]
Ridker PM, Tardif JC, Amarenco P, Duggan W, Glynn RJ, Jukema JW, Kastelein JJP, Kim AM, Koenig W, Nissen S, Revkin J, Rose LM, Santos RD, Schwartz PF, Shear CL, Yunis C, Lipid-Reduction Variability and Antidrug-Antibody Formation with Bococizumab. NEW ENGL J MED 2017;376 (16):1517-1526 [PubMed]
Robinson JG, Rosenson RS, Farnier M, Chaudhari U, Sasiela WJ, Merlet L, Miller K, Kastelein JJP, Safety of Very Low Low-Density Lipoprotein Cholesterol Levels With Alirocumab: Pooled Data From Randomized Trials. J AM COLL CARDIOL 2017;69 (5):471-482 [PubMed]
Sjouke B. Extreme phenotypes in hypercholesterolemia. S.l.: s.n.; 2017. 367p. ISBN 978-94-028-0486-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Hovingh GK)
Sjouke B, Yahya R, Tanck MWT, Defesche JC, de Graaf J, Wiegman A, Kastelein JJP, Mulder MT, Hovingh GK, Roeters van Lennep JE, Plasma lipoprotein(a) levels in patients with homozygous autosomal dominant hypercholesterolemia. J CLIN LIPIDOL 2017;11 (2):507-514 [PubMed]
Stein EA, Dann EJ, Wiegman A, Skovby F, Gaudet D, Sokal E, Charng MJ, Mohamed M, Luirink I, Raichlen JS, Sundén M, Carlsson SC, Raal FJ, Kastelein JJP, Efficacy of Rosuvastatin in Children With Homozygous Familial Hypercholesterolemia and Association With Underlying Genetic Mutations. J AM COLL CARDIOL 2017;70 (9):1162-1170 [PubMed]
Stoekenbroek RM, Kastelein JJP, Dyslipidaemia: Statin-associated muscle symptoms - really all in the mind?. NAT REV CARDIOL 2017;14 (8):445-446 [PubMed]
Stoekenbroek RM, Kastelein JJP, Hovingh GK, Can we afford not to screen for FH?. EUR HEART J 2017;38 (23):1840-1842 [PubMed]
Ursoniu S, Mikhailidis DP, Serban MC, Penson P, Toth PP, Ridker PM, Ray KK, Kees Hovingh G, Kastelein JJ, Hernandez AV, Manson JE, Rysz J, Banach M, The effect of statins on cardiovascular outcomes by smoking status: A systematic review and meta-analysis of randomized controlled trials. PHARMACOL RES 2017;122:105-117 [PubMed]
Vallejo-Vaz AJ, Robertson M, Catapano AL, Watts GF, Kastelein JJ, Packard CJ, Ford I, Ray KK, LDL-Cholesterol Lowering for the Primary Prevention of Cardiovascular Disease Among Men with Primary Elevations of LDL-Cholesterol Levels of 190 mg/dL or Above: Analyses from the WOSCOPS 5-year Randomised Trial and 20-year Observational Follow-Up. CIRCULATION 2017;ahead of print [PubMed]
van Capelleveen JC, Bernelot Moens SJ, Yang X, Kastelein JJP, Wareham NJ, Zwinderman AH, Stroes ESG, Witztum JL, Hovingh GK, Khaw KT, Boekholdt SM, Tsimikas S, Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study. ARTERIOSCL THROM VAS 2017;37 (6):1206-1212 [PubMed]
van Capelleveen JC, Bochem AE, Boekholdt SM, Mora S, Hoogeveen RC, Ballantyne CM, Ridker PM, Sun W, Barter PJ, Tall AR, Zwinderman AH, Kastelein JJP, Wareham NJ, Khaw KT, Hovingh GK, Association of High-Density Lipoprotein-Cholesterol Versus Apolipoprotein A-I With Risk of Coronary Heart Disease: The European Prospective Investigation Into Cancer-Norfolk Prospective Population Study, the Atherosclerosis Risk in Communities Study, and the Women's Health Study. J AM HEART ASSOC 2017;6 (8):e006636 [PubMed]
Verbeek R, Boyer M, Boekholdt SM, Hovingh GK, Kastelein JJP, Wareham N, Khaw KT, Arsenault BJ, Carriers of the PCSK9 R46L Variant Are Characterized by an Antiatherogenic Lipoprotein Profile Assessed by Nuclear Magnetic Resonance Spectroscopy-Brief Report. ARTERIOSCL THROM VAS 2017;37 (1):43-48 [PubMed]
Verbeek R, Sandhu MS, Hovingh GK, Sjouke B, Wareham NJ, Zwinderman AH, Kastelein JJP, Khaw KT, Tsimikas S, Boekholdt SM, Lipoprotein(a) Improves Cardiovascular Risk Prediction Based on Established Risk Algorithms. J AM COLL CARDIOL 2017;69 (11):1513-1515 [PubMed]
Arsenault BJ, Kohli P, Lambert G, Demicco DA, Laskey R, Messig MM, Kastelein JJP, Waters DD, Emerging Cardiovascular Disease Biomarkers and Incident Diabetes Mellitus Risk in Statin-Treated Patients With Coronary Artery Disease (from the Treating to New Targets [TNT] Study). AM J CARDIOL 2016;118 (4):494-498 [PubMed]
Bangalore S, Fayyad R, Kastelein JJ, Laskey R, Amarenco P, Demicco DA, Waters DD, 2013 Cholesterol Guidelines Revisited: Percent LDL Cholesterol Reduction or Attained LDL Cholesterol Level or Both for Prognosis?. AM J MED 2016;129 (4):384-391 [PubMed]
Bays HE, Hallén J, Vige R, Fraser D, Zhou R, Hustvedt SO, Orloff DG, Kastelein JJP, Icosabutate for the treatment of very high triglycerides: A placebo-controlled, randomized, double-blind, 12-week clinical trial. J CLIN LIPIDOL 2016;10 (1):181-91.e1-2 [PubMed]
Besseling J. The extended phenotype of familial hypercholesterolemia. S.l.: s.n.; 2016. 283p. ISBN 978-94-6233-388-8 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Hovingh GK, Hutten BA)
Besseling J, Hovingh GK, Huijgen R, Kastelein JJP, Hutten BA, Statins in Familial Hypercholesterolemia: Consequences for Coronary Artery Disease and All-Cause Mortality. J AM COLL CARDIOL 2016;68 (3):252-260 [PubMed]
Besseling J, Huijgen R, Martin SS, Hutten BA, Kastelein JJP, Hovingh GK, Clinical phenotype in relation to the distance-to-index-patient in familial hypercholesterolemia. ATHEROSCLEROSIS 2016;246:1-6 [PubMed]
Blom DJ, Fayad ZA, Kastelein JJP, Larrey D, Makris L, Schwamlein C, Bloeden L, Underberg J, LOWER, a registry of lomitapide-treated patients with homozygous familial hypercholesterolemia: Rationale and design. J CLIN LIPIDOL 2016;10 (2):273-282 [PubMed]
Braamskamp MJAM, Kastelein JJP, Kusters DM, Hutten BA, Wiegman A, Statin Initiation During Childhood in Patients With Familial Hypercholesterolemia: Consequences for Cardiovascular Risk. J AM COLL CARDIOL 2016;67 (4):455-456 [PubMed]
Duell PB, Santos RD, Kirwan BA, Witztum JL, Tsimikas S, Kastelein JJP, Long-term mipomersen treatment is associated with a reduction in cardiovascular events in patients with familial hypercholesterolemia. J CLIN LIPIDOL 2016;10 (4):1011-1021 [PubMed]
Elbers LPB, Kastelein JJP, Sjouke B, Thyroid Hormone Mimetics: the Past, Current Status and Future Challenges. CURR ATHEROSCLER REP 2016;18 (3):14 [PubMed]
Gibson CM, Korjian S, Tricoci P, Daaboul Y, Alexander JH, Steg PG, Lincoff AM, Kastelein JJP, Mehran R, D'Andrea D, Merkely B, Zarebinski M, Ophius TO, Harrington RA, Rationale and design of Apo-I Event Reduction in Ischemic Syndromes I (AEGIS-I): A phase 2b, randomized, placebo-controlled, dose-ranging trial to investigate the safety and tolerability of CSL112, a reconstituted, infusible, human apoA-I, after acute myocardial infarction. AM HEART J 2016;180:22-28 [PubMed]
Gitt AK, Lautsch D, Ferrieres J, Kastelein J, Drexel H, Horack M, Brudi P, Vanneste B, Bramlage P, Chazelle F, Sazonov V, Ambegaonkar B, Contemporary data on low-density lipoprotein cholesterol target value attainment and distance to target in a cohort of 57,885 statin-treated patients by country and region across the world. DATA BRIEF 2016;9:616-620 [PubMed]
Gitt AK, Lautsch D, Ferrieres J, Kastelein J, Drexel H, Horack M, Brudi P, Vanneste B, Bramlage P, Chazelle F, Sazonov V, Ambegaonkar B, Low-density lipoprotein cholesterol in a global cohort of 57,885 statin-treated patients. ATHEROSCLEROSIS 2016;255:200-209 [PubMed]
Hovingh GK, Kastelein JJP, Diagnosis and Management of Individuals With Heterozygous Familial Hypercholesterolemia: Too Late and Too Little. CIRCULATION 2016;134 (10):710-712 [PubMed]
Kaasenbrood L, Boekholdt SM, van der Graaf Y, Ray KK, Peters RJG, Kastelein JJP, Amarenco P, LaRosa JC, Cramer MJM, Westerink J, Kappelle LJ, de Borst GJ, Visseren FLJ, Distribution of Estimated 10-Year Risk of Recurrent Vascular Events and Residual Risk in a Secondary Prevention Population. CIRCULATION 2016;134 (19):1419-1429 [PubMed]
Kastelein JJP, Hallén J, Vige R, Fraser DA, Zhou R, Hustvedt SO, Orloff DG, Bays HE, Icosabutate, a Structurally Engineered Fatty Acid, Improves the Cardiovascular Risk Profile in Statin-Treated Patients with Residual Hypertriglyceridemia. CARDIOLOGY 2016;135 (1):3-12 [PubMed]
Kastelein JJP, Nissen SE, Rader DJ, Hovingh GK, Wang MD, Shen T, Krueger KA, Safety and efficacy of LY3015014, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9): a randomized, placebo-controlled Phase 2 study. EUR HEART J 2016;37 (17):1360-1369 [PubMed]
Kusters M. Familial hypercholesterolemia: Screening, treatment and follow-up from pregnancy into young adulthood. S.l.: s.n.; 2016. 423p. ISBN 978-94-6233-222-5 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP, Wijburg FA; copromotor(s): Hutten BA, Wiegman A)
Macpherson M, Hamrén B, Braamskamp MJAM, Kastelein JJP, Lundström T, Martin PD, Population pharmacokinetics of rosuvastatin in pediatric patients with heterozygous familial hypercholesterolemia. EUR J CLIN PHARMACOL 2016;72 (1):19-27 [PubMed]
Maiwald S, Motazacker MM, van Capelleveen JC, Sivapalaratnam S, van der Wal AC, van der Loos C, Kastelein JJP, Ouwehand WH, Hovingh GK, Trip MD, van Buul JD, Dallinga-Thie GM, A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis. EUR J HUM GENET 2016;24 (1):86-91 [PubMed]
Michael Gibson C, Korjian S, Tricoci P, Daaboul Y, Yee M, Jain P, Alexander JH, Steg PG, Lincoff AM, Kastelein JJP, Mehran R, D'Andrea DM, Deckelbaum LI, Merkely B, Zarebinski M, Ophuis TO, Harrington RA, Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial Infarction: The AEGIS-I Trial (ApoA-I Event Reducing in Ischemic Syndromes I). CIRCULATION 2016;134 (24):1918-1930 [PubMed]
Nicholls SJ, Puri R, Anderson T, Ballantyne CM, Cho L, Kastelein JJP, Koenig W, Somaratne R, Kassahun H, Yang J, Wasserman SM, Scott R, Ungi I, Podolec J, Ophuis AO, Cornel JH, Borgman M, Brennan DM, Nissen SE, Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients: The GLAGOV Randomized Clinical Trial. JAMA-J AM MED ASSOC 2016;316 (22):2373-2384 [PubMed]
Nicholls SJ, Puri R, Wolski K, Ballantyne CM, Barter PJ, Brewer HB, Kastelein JJP, Hu B, Uno K, Kataoka Y, Herrman JPR, Merkely B, Borgman M, Nissen SE, Effect of the BET Protein Inhibitor, RVX-208, on Progression of Coronary Atherosclerosis: Results of the Phase 2b, Randomized, Double-Blind, Multicenter, ASSURE Trial. AM J CARDIOVASC DRUG 2016;16 (1):55-65 [PubMed]
Patel AP, Peloso GM, Pirruccello JP, Johansen CT, Dubé JB, Larach DB, Ban MR, Dallinge-Thie GM, Gupta N, Boehnke M, Abecasis GR, Kastelein JJP, Hovingh GK, Hegele RA, Rader DJ, Kathiresan S, Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution. ATHEROSCLEROSIS 2016;250:63-68 [PubMed]
Patel MR, Armstrong PW, Bhatt DL, Braunwald E, Camm AJ, Fox KAA, Harrington RA, Hiatt WR, James SK, Kirtane AJ, Leon MB, Lincoff AM, Mahaffey KW, Mauri L, Mehran R, Mehta SR, Montalescot G, Nicholls SJ, Perkovic V, Peterson ED, Pocock SJ, Roe MT, Sabatine MS, Sekeres M, Solomon SD, Steg G, Stone GW, van de Werf F, Wallentin L, White HD, Gibson M [Contributors: Patel MR, Armstrong PW, Bhatt DL, Braunwald E, Camm AJ, Fox KAA, Harrington RA, Hiatt WR, James SK, Kirtane AJ, Leon MB, Lincoff AM, Mahaffey KW, Mauri L, Mehran R, Mehta SR, Montalescot G, Nicholls SJ, Perkovic V, Peterson ED, Pocock SJ, Roe MT, Sabatine MS, Sekeres M, Solomon SD, Steg G, Stone GW, van de Werf F, Wallentin L, White HD, Gibson CM, Achaval-Giraud A, Aguilar Salinas CA, Alexander JH, Almeida ED, Ambrosio G, Ann R, Annichino-Bizzacchi JM, Antman E, Antonescu A, Antorrena-Miranda I, Apartsin K, Arce M, Arellano-Rodrigo E, Assadourian A, Astrahanceva A, Badings E, Bainey KR, Banik M, Belisário Falchetto E, Berrospi P, Bezrodna L, Bianco HT, Blikhar O, Blokhin A, Bobade M, Bohula E, Booth DC, Botta CE, Bozkurt ED, Bradley C, Brito M, Brugaletta S, Burmak LG, Button A, Bylova N, Byrne J, Calin P, Carrión AM, Célia Corrêa e Castro Marinho M, Celic V, Cerci RJ, Cervantes Hurtado A, Cherkezov E, Chopskie E, Conrado Y, Crisan C, Cuervo A, Dattani ID, de los Ríos Ibarra MO, de Padua Mansur A, de Souza Pantano G, del Razo-Olvera F, Delia M, Dellborg M, Dias C, Díaz Díaz JL, Dimov B, Dolzhenko M, Dominguez Simeon MJ, Dumitrascu A, El Din El Shafey W, El Jarroudi F, Estrada RI, Evans S, Ezekowitz J, Ferkl R, Fil W, Fimiani F, Finfer S, Flecknoe-Brown S, Forero Gómez JE, Fresco C, Galatius S, Gandur H, Garcia B, Garcia L, Garcia Alvarez JA, García-Hernández PA, Garvey M, Georgiev B, Gibson A, Giugliano RP, Godoy Palomino AL, Goloborodko B, Goloshchekin B, González Castaño M, González Martínez FJ, GonzalezColaso P, Goodman S, Gupta S, Hajko E, Hall R, Hamilton M, Hammond N, Hansen O, Henderson RB, Hernandez A, Hovingh GK, Hueb W, Husted S, Igor A, Irina M, Jambaulikar G, Jimeno CA, Johansson Å, Johnson B, Karlsson JE, Kastelein J, Kinoshita C, Klausner HA, Koura F, Koval O, Krievins D, Kuehl A, Kulyk A, Kunecki M, Kutsogiannis DJ, Lakatos F, Lareva N, Lassila R, Legkonogov A, Lema J, Lenka R, Lewis B, Lip GYH, Łukaszewicz M, Lypovetska S, Macchiavelli AJ, Mader P, Mafrici A, Maguire H, Maia LN, Malygin A, Malynovsky Y, Mani A, Manyari D, Margoczy R, Marino M, Martin-Loeches I, Matteo M, McCollum C, Meelu OA, Melendez G, Meseguer ML, Minarik P, Minhas E, Misik KK, Misir M, Monteagudo Canto A, Montecinos H, Morales A, Mot S, Mottershead J, Murakami K, Myronenko S, Myśliwiec BJ, Nadbrzezny P, Nicholls S, Nikolsky E, O'Connor M, Obaitan I, O'Donoghue M, Ohman EM, Omerovic E, Osborne J, Oyesile B, Parliteanu O, Pavelko M, Peacock WF, Penzes J, Pham DN, Pilgrim T, Piskorz D, Pollak A, Ponce G, Popescu M, Prokop D, Prostov I, Quadros A, Raev D, Rafalskiy V, Rastogi P, Real V, Resnick M, Ribas Fortes JA, Riding D, Rincón LM, Riojas CM, Risolo A, Riu FR, Rogers S, Rostislav N, Rubenfire M, Ruff CT, Ruiz A, Ruiz-Artacho P, Rukhadze T, Sabaté M, Sadauskas S, Sauque-Reyna L, Schaer GL, Seeber M, Segura L, Selnicyn I, Seoane A, Serrano P, Shangina O, Sharma A, Sharma S, Shochat MK, Shulikovsky E, Singh BKJ, Sobrino J, Sokol SI, Sosa-Padilla M, Sosovec D, Sreckovic M, Stanley DE, Stepanova S, Stepinska J, Sterling FD, Stukena I, Sudar Z, Sulosaari S, Taggeselle J, Tanana O, Tarantino E, Tewari R, Thijs V, Tica O, Tikhonova S, Tinnirello V, Toloza RM, Trujillo-Santos J, Trygg N, Tuck M, Uvaroviene I, Vagaonescu T, van de Loo R, van Diepen S, van Roest C, Vanhooren G, Vidal-Perez R, Vikman S, Vishneva E, Vyshnevska I, Waisman G, Weil R, Weimar C, Weiner BH, Welsh RC, Winterrowd D, Wiviott SD, Wyse DG, Yakusevich V, Yulia M, Zapata G, Zeymer U, Zielinski M, Ziman RB, Zoghbi J]] , Sharing Data from Cardiovascular Clinical Trials - A Proposal. NEW ENGL J MED 2016;375 (5):407-409 [PubMed]
Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE, Deshmukh HA, Evans DS, Feng Q, Li X, Smit RAJ, Smith AV, Sun F, Taylor KD, Arnold AM, Barnes MR, Barratt BJ, Betteridge J, Boekholdt SM, Boerwinkle E, Buckley BM, Chen YDI, de Craen AJM, Cummings SR, Denny JC, Dubé MP, Durrington PN, Eiriksdottir G, Ford I, Guo X, Harris TB, Heckbert SR, Hofman A, Hovingh GK, Kastelein JJP, Launer LJ, Liu CT, Liu Y, Lumley T, McKeigue PM, Munroe PB, Neil A, Nickerson DA, Nyberg F, O'Brien E, O'Donnell CJ, Post W, Poulter N, Vasan RS, Rice K, Rich SS, Rivadeneira F, Sattar N, Sever P, Shaw-Hawkins S, Shields DC, Slagboom PE, Smith NL, Smith JD, Sotoodehnia N, Stanton A, Stott DJ, Stricker BH, Stürmer T, Uitterlinden AG, Wei WQ, Westendorp RGJ, Whitsel EA, Wiggins KL, Wilke RA, Ballantyne CM, Colhoun HM, Cupples LA, Franco OH, Gudnason V, Hitman G, Palmer CNA, Psaty BM, Ridker PM, Stafford JM, Stein CM, Tardif JC, Caulfield MJ, Jukema JW, Rotter JI, Krauss RM, Meta-analysis of genome-wide association studies of HDL cholesterol response to statins. J MED GENET 2016;53 (12):835-845 [PubMed]
Puri R, Nissen SE, Somaratne R, Cho L, Kastelein JJP, Ballantyne CM, Koenig W, Anderson TJ, Yang J, Kassahun H, Wasserman SM, Scott R, Borgman M, Nicholls SJ, Impact of PCSK9 inhibition on coronary atheroma progression: Rationale and design of Global Assessment of Plaque Regression with a PCSK9 Antibody as Measured by Intravascular Ultrasound (GLAGOV). AM HEART J 2016;176:83-92 [PubMed]
Raal FJ, Braamskamp MJ, Selvey SL, Sensinger CH, Kastelein JJ, Pediatric experience with mipomersen as adjunctive therapy for homozygous familial hypercholesterolemia. J CLIN LIPIDOL 2016;10 (4):860-869 [PubMed]
Ridker PM, Amarenco P, Brunell R, Glynn RJ, Jukema JW, Kastelein JJP, Koenig W, Nissen S, Revkin J, Santos RD, Schwartz PF, Yunis C, Tardif JC, Evaluating bococizumab, a monoclonal antibody to PCSK9, on lipid levels and clinical events in broad patient groups with and without prior cardiovascular events: Rationale and design of the Studies of PCSK9 Inhibition and the Reduction of vascular Events (SPIRE) Lipid Lowering and SPIRE Cardiovascular Outcomes Trials. AM HEART J 2016;178:135-144 [PubMed]
Robinson JG, Huijgen R, Ray K, Persons J, Kastelein JJP, Pencina MJ, Determining When to Add Nonstatin Therapy: A Quantitative Approach. J AM COLL CARDIOL 2016;68 (22):2412-2421 [PubMed]
Sahebkar A, Serban C, Ursoniu S, Mikhailidis DP, Undas A, Lip GYH, Bittner V, Ray K, Watts GF, Hovingh GK, Rysz J, Kastelein JJP, Banach M, The impact of statin therapy on plasma levels of von Willebrand factor antigen. Systematic review and meta-analysis of randomised placebo-controlled trials. THROMB HAEMOSTASIS 2016;115 (3):520-532 [PubMed]
Sjouke B, Defesche JC, Hartgers ML, Wiegman A, Roeters van Lennep JE, Kastelein JJ, Hovingh GK, Double-heterozygous autosomal dominant hypercholesterolemia: Clinical characterization of an underreported disease. J CLIN LIPIDOL 2016;10 (6):1462-1469 [PubMed]
Sjouke B, Tanck MWT, Fouchier SW, Defesche JC, Hutten BA, Wiegman A, Kastelein JJP, Hovingh GK, Children with hypercholesterolemia of unknown cause: Value of genetic risk scores. J CLIN LIPIDOL 2016;10 (4):851-859 [PubMed]
Stroes E, Guyton JR, Lepor N, Civeira F, Gaudet D, Watts GF, Baccara-Dinet MT, Lecorps G, Manvelian G, Farnier M [Contributors: Kostner K, Lehman S, Descamps O, Gheyle L, Mathieu C, Bergeron J, Elliott T, Girard G, Gupta A, Hoag G, Hove J, Jeppesen J, Kjærulf JH, Klarlund K, Thomsen KK, Basart DCG, Kooy A, Liem A, Swart H, Troquay R, van Het Hof-Wiersma J, Viergever P, Visseren F, Doughty RN, Scott R, Calvo C, Díaz-Díaz JL, Fuentes F, Gil-Extremera B, Jericó C, Matas Pericas L, Mediavilla Garcia JD, Bolster DE, Koren M, El Shahawy M, Vardi G, Weinstein D, Zuzarte K, Ginsberg H, Robinson JG, Rader DJ, Cannon CP, Colhoun H, Kastelein JJP, Huo Y, Olsson A, Waters D, Larrey D, Rosenson RS, Patriarca PA, Molenberghs G, Tricoci P, Mahaffey KW, Lopes RD, Shah BR, Mehta RH, Roe MT, Eapen Z, Armaganijan L, Bertolami A, Leonardi S, Kolls BJ, Jordan JD, Ducrocq G, Puymirat E, Mathews R]] , Efficacy and Safety of Alirocumab 150 mg Every 4 Weeks in Patients With Hypercholesterolemia Not on Statin Therapy: The ODYSSEY CHOICE II Study. J AM HEART ASSOC 2016;5 (9):e003421 [PubMed]
Vallejo-Vaz AJ, Akram A, Kondapally Seshasai SR, Cole D, Watts GF, Hovingh GK, Kastelein JJP, Mata P, Raal FJ, Santos RD, Soran H, Freiberger T, Abifadel M, Aguilar-Salinas CA, Alnouri F, Alonso R, Al-Rasadi K, Banach M, Bogsrud MP, Bourbon M, Bruckert E, Car J, Ceska R, Corral P, Descamps O, Dieplinger H, Do CT, Durst R, Ezhov MV, Fras Z, Gaita D, Gaspar IM, Genest J, Harada-Shiba M, Jiang L, Kayikcioglu M, Lam CSP, Latkovskis G, Laufs U, Liberopoulos E, Lin J, Lin N, Maher V, Majano N, Marais AD, März W, Mirrakhimov E, Miserez AR, Mitchenko O, Nawawi H, Nilsson L, Nordestgaard BG, Paragh G, Petrulioniene Z, Pojskic B, Reiner Ž, Sahebkar A, Santos LE, Schunkert H, Shehab A, Slimane MN, Stoll M, Su TC, Susekov A, Tilney M, Tomlinson B, Tselepis AD, Vohnout B, Widén E, Yamashita S, Catapano AL, Ray KK, Pooling and expanding registries of familial hypercholesterolaemia to assess gaps in care and improve disease management and outcomes: Rationale and design of the global EAS Familial Hypercholesterolaemia Studies Collaboration. ATHEROSCLEROSIS SUPP 2016;22:1-32 [PubMed]
van Capelleveen JC, Kastelein JJP, Zwinderman AH, van Deventer SJH, Collins HL, Adelman SJ, Round P, Ford J, Rader DJ, Hovingh GK, Effects of the cholesteryl ester transfer protein inhibitor, TA-8995, on cholesterol efflux capacity and high-density lipoprotein particle subclasses. J CLIN LIPIDOL 2016;10 (5):1137-1144 [PubMed]
Zanoni P, Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M, DerOhannessian S, Kontush A, Surendran P, Saleheen D, Trompet S, Jukema JW, de Craen A, Deloukas P, Sattar N, Ford I, Packard C, Majumder AaS, Alam DS, Di Angelantonio E, Abecasis G, Chowdhury R, Erdmann J, Nordestgaard BG, Nielsen SF, Tybjærg-Hansen A, Schmidt RF, Kuulasmaa K, Liu DJ, Perola M, Blankenberg S, Salomaa V, Männistö S, Amouyel P, Arveiler D, Ferrieres J, Müller-Nurasyid M, Ferrario M, Kee F, Willer CJ, Samani N, Schunkert H, Butterworth AS, Howson JMM, Peloso GM, Stitziel NO, Danesh J, Kathiresan S, Rader DJ [Contributors: Watson S, Schmidt EM, Sengupta S, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K, Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkilä K, Hyppönen E, Isaacs A, Jackson AU, Johansson Å, Johnson T, Kaakinen M, Kettunen J, Kleber ME, Li X, Luan Ja, Lyytikäinen LP, Magnusson PKE, Mangino M, Mihailov E, Montasser ME, Nolte IM, O'Connell JR, Palmer CD, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, van den Herik EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher D, Asiki G, Barroso I, Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney ASF, Döring A, Elliott P, Epstein SE, Eyjolfsson GI, Gigante B, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hallmans G, Hartikainen AL, Hayward C, Hernandez D, Hicks AA, Holm H, Hung YJ, Illig T, Jones MR, Kaleebu P, Kastelein JJP, Khaw KT, Kim E, Klopp N, Komulainen P, Kumari M, Langenberg C, Lehtimäki T, Lin SY, Lindström J, Loos RJF, Mach F, McArdle WL, Meisinger C, Mitchell BD, Müller G, Nagaraja R, Narisu N, Nieminen TVM, Nsubuga RN, Olafsson I, Ong KK, Palotie A, Papamarkou T, Pomilla C, Pouta A, Reilly MP, Ridker PM, Rivadeneira F, Rudan I, Ruokonen A, Scharnagl H, Seeley J, Silander K, Stancáková A, Stirrups K, Swift AJ, Tiret L, Uitterlinden AG, van Pelt LJ, Vedantam S, Wainwright N, Wijmenga C, Wild SH, Willemsen G, Wilsgaard T, Wilson JF, Young EH, Zhao JH, Adair LS, Arveiler D, Assimes TL, Bandinelli S, Bennett F, Bochud M, Boehm BO, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier M, Campbell H, Chakravarti A, Chambers JC, Chen YDI, Collins FS, Cooper RS, Dedoussis G, de Faire U, Feranil AB, Ferrucci L, Freimer NB, Gieger C, Groop LC, Gudnason V, Gyllensten U, Hamsten A, Harris TB, Hingorani A, Hirschhorn JN, Hofman A, Hovingh GK, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Iribarren C, Järvelin MR, Jula A, Kähönen M, Kaprio J, Kesäniemi A, Kivimaki M, Kooner JS, Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J, Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren CM, Martin NG, März W, McCarthy MI, McKenzie CA, Meneton P, Metspalu A, Moilanen L, Morris AD, Munroe PB, Njølstad I, Pedersen NL, Power C, Pramstaller PP, Price JF, Psaty BM, Quertermous T, Rauramaa R, Salomaa V, Sanghera DK, Saramies J, Schwarz PEH, Sheu WHH, Shuldiner AR, Siegbahn A, Spector TD, Stefansson K, Strachan DP, Tayo BO, Tremoli E, Tuomilehto J, Uusitupa M, van Duijn CM, Vollenweider P, Wallentin L, Wareham NJ, Whitfield JB, Wolffenbuttel BHR, Ordovas JM, Boerwinkle E, Palmer CNA, Thorsteinsdottir U, Chasman DI, Rotter JI, Franks PW, Riatti S, Cupples LA, Sandhu MS, Rich SS, Boehnke M, Deloukas P, Mohlke KL, Ingelsson E, Gu D, Roberts R, Watkins H, Blankenberg S, Clarke R, Collins R, Kim BJ, McPherson R, Nieminen MS, O'Donnell C, Schreiber S, Zalloua PA]] , Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. SCIENCE 2016;351 (6278):1166-1171 [PubMed]
Arsenault BJ, Boyer M, Kastelein JJP, What does the future hold for cholesteryl ester transfer protein inhibition?. CURR OPIN LIPIDOL 2015;26 (6):526-535 [PubMed]
Ballantyne CM, Braeckman RA, Bays HE, Kastelein JJ, Otvos JD, Stirtan WG, Doyle RT Jr, Soni PN, Juliano RA, Effects of icosapent ethyl on lipoprotein particle concentration and size in statin-treated patients with persistent high triglycerides (the ANCHOR Study). J CLIN LIPIDOL 2015;9 (3):377-383 [PubMed]
Banach M, Serban C, Sahebkar A, Mikhailidis DP, Ursoniu S, Ray KK, Rysz J, Toth PP, Muntner P, Mosteoru S, García-García HM, Hovingh GK, Kastelein JJP, Serruys PW, Impact of statin therapy on coronary plaque composition: a systematic review and meta-analysis of virtual histology intravascular ultrasound studies. BMC MED 2015;13 (1):229 [PubMed]
Barter PJ, Nicholls SJ, Kastelein JJP, Rye KA, Is Cholesteryl Ester Transfer Protein Inhibition an Effective Strategy to Reduce Cardiovascular Risk? CETP Inhibition as a Strategy to Reduce Cardiovascular Risk: The Pro Case. CIRCULATION 2015;132 (5):423-432 [PubMed]
Besseling J, Kastelein JJP, Defesche JC, Hutten BA, Hovingh GK, Association Between Familial Hypercholesterolemia and Prevalence of Type 2 Diabetes Mellitus. JAMA-J AM MED ASSOC 2015;313 (10):1029-1036 [PubMed]
Besseling J, Sjouke B, Kastelein JJP, Screening and treatment of familial hypercholesterolemia - Lessons from the past and opportunities for the future (based on the Anitschkow Lecture 2014). ATHEROSCLEROSIS 2015;241 (2):597-606 [PubMed]
Boekholdt SM, Hovingh GK, Waters DD, Grundy SM, Kastelein JJP, Reply: statin-induced low low-density lipoprotein cholesterol level: is lower better?. J AM COLL CARDIOL 2015;65 (1):109 [PubMed]
Braamskamp M. Management of pediatric familial hypercholesterolemia; growing older, getting wiser. S.l.: s.n.; 2015. 237p. ISBN 978-94-6233-150-1 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP, Wijburg FA; copromotor(s): Hutten BA, Wiegman A)
Braamskamp MJAM, Kusters DM, Avis HJ, Smets EMA, Wijburg FA, Kastelein JJP, Wiegman A, Hutten BA, Long-term statin treatment in children with familial hypercholesterolemia: more insight into tolerability and adherence. PEDIATR DRUGS 2015;17 (2):159-166 [PubMed]
Braamskamp MJAM, Kusters DM, Wiegman A, Avis HJ, Wijburg FA, Kastelein JJP, van Trotsenburg ASP, Hutten BA, Gonadal steroids, gonadotropins and DHEAS in young adults with familial hypercholesterolemia who had initiated statin therapy in childhood. ATHEROSCLEROSIS 2015;241 (2):427-432 [PubMed]
Braamskamp MJAM, Langslet G, McCrindle BW, Cassiman D, Francis GA, Gagné C, Gaudet D, Morrison KM, Wiegman A, Turner T, Kusters DM, Miller E, Raichlen JS, Wissmar J, Martin PD, Stein EA, Kastelein JJP, Efficacy and safety of rosuvastatin therapy in children and adolescents with familial hypercholesterolemia: Results from the CHARON study. J CLIN LIPIDOL 2015;9 (6):741-750 [PubMed]
Braamskamp MJAM, Stefanutti C, Langslet G, Drogari E, Wiegman A, Hounslow N, Kastelein JJP [Contributors: Kolovou G, Elisaf M, Middeldorp S, García Jiménez MC, Ponce EC, Di Giacomo S, Morozzi C, Pozzi C, Peretti N, Thompson G, McCrindle B, Guardamagna O]] , Efficacy and Safety of Pitavastatin in Children and Adolescents at High Future Cardiovascular Risk. J PEDIATR-US 2015;167 (2):338-+ [PubMed]
de Backer G, Besseling J, Chapman J, Hovingh GK, Kastelein JJP, Kotseva K, Ray K, Reiner Ž, Wood D, de Bacquer D, Prevalence and management of familial hypercholesterolaemia in coronary patients: An analysis of EUROASPIRE IV, a study of the European Society of Cardiology. ATHEROSCLEROSIS 2015;241 (1):169-175 [PubMed]
de Backer G, Kastelein JJP, Landmesser U, The year in cardiology 2014: prevention. EUR HEART J 2015;36 (4):214-218 [PubMed]
Do R, Stitziel NO, Won HH, Jørgensen AB, Duga S, Angelica Merlini P, Kiezun A, Farrall M, Goel A, Zuk O, Guella I, Asselta R, Lange LA, Peloso GM, Auer PL, Girelli D, Martinelli N, Farlow DN, DePristo MA, Roberts R, Stewart AFR, Saleheen D, Danesh J, Epstein SE, Sivapalaratnam S, Hovingh GK, Kastelein JJ, Samani NJ, Schunkert H, Erdmann J, Shah SH, Kraus WE, Davies R, Nikpay M, Johansen CT, Wang J, Hegele RA, Hechter E, Marz W, Kleber ME, Huang J, Johnson AD, Li M, Burke GL, Gross M, Liu Y, Assimes TL, Heiss G, Lange EM, Folsom AR, Taylor HA, Olivieri O, Hamsten A, Clarke R, Reilly DF, Yin W, Rivas MA, Donnelly P, Rossouw JE, Psaty BM, Herrington DM, Wilson JG, Rich SS, Bamshad MJ, Tracy RP, Cupples LA, Rader DJ, Reilly MP, Spertus JA, Cresci S, Hartiala J, Tang WHW, Hazen SL, Allayee H, Reiner AP, Carlson CS, Kooperberg C, Jackson RD, Boerwinkle E, Lander ES, Schwartz SM, Siscovick DS, McPherson R, Tybjaerg-Hansen A, Abecasis GR, Watkins H, Nickerson DA, Ardissino D, Sunyaev SR, O'Donnell CJ, Altshuler D, Gabriel S, Kathiresan S [Contributors: Gabriel SB, Altshuler DM, Abecasis GR, Allayee H, Cresci S, Daly MJ, de Bakker PIW, DePristo MA, Do R, Donnelly P, Farlow DN, Fennell T, Garimella K, Hazen SL, Hu Y, Jordan DM, Jun G, Kathiresan S, Kang HM, Kiezun A, Lettre G, Li B, Li M, Newton-Cheh CH, Padmanabhan S, Peloso G, Pulit S, Rader DJ, Reich D, Reilly MP, Rivas MA, Schwartz S, Scott L, Siscovick DS, Spertus JA, Stitziel NO, Stoletzki N, Sunyaev SR, Voight BF, Willer CJ, Rich SS, Akylbekova E, Atwood LD, Ballantyne CM, Barbalic M, Barr RG, Benjamin EJ, Bis J, Boerwinkle E, Bowden DW, Brody J, Budoff M, Burke G, Buxbaum S, Carr J, Chen DT, Chen IY, Chen WM, Concannon P, Crosby J, Cupples LA, D'Agostino R, DeStefano AL, Dreisbach A, Dupuis J, Durda JP, Ellis J, Folsom AR, Fornage M, Fox CS, Fox E, Funari V, Ganesh SK, Gardin J, Goff D, Gordon O, Grody W, Gross M, Guo X, Hall IM, Heard-Costa NL, Heckbert SR, Heintz N, Herrington DM, Hickson D, Huang J, Hwang SJ, Jacobs DR, Jenny NS, Johnson AD, Johnson CW, Kawut S, Kronmal R, Kurz R, Lange EM, Lange LA, Larson MG, Lawson M, Lewis CE, Levy D, Li D, Lin H, Liu C, Liu J, Liu K, Liu X, Liu Y, Longstreth WT, Loria C, Lumley T, Lunetta K, Mackey AJ, Mackey R, Manichaikul A, Maxwell T, McKnight B, Meigs JB, Morrison AC, Musani SK, Mychaleckyj JC, Nettleton JA, North K, O'Donnell CJ, O'Leary D, Ong FS, Palmas W, Pankow JS, Pankratz ND, Paul S, Perez M, Person SD, Polak J, Post WS, Psaty BM, Quinlan AR, Raffel LJ, Ramachandran VS, Reiner AP, Rice K, Rotter JI, Sanders JP, Schreiner P, Seshadri S, Shea S, Sidney S, Silverstein K, Smith NL, Sotoodehnia N, Srinivasan A, Taylor HA, Taylor K, Thomas F, Tracy RP, Tsai MY, Volcik KA, Wassel CL, Watson K, Wei G, White W, Wiggins KL, Wilk JB, Williams OD, Wilson G, Wilson JG, Wolf P, Zakai NA, Hardy J, Meschia JF, Nalls M, Singleton A, Worrall B, Bamshad MJ, Barnes KC, Abdulhamid I, Accurso F, Anbar R, Beaty T, Bigham A, Black P, Bleecker E, Buckingham K, Cairns AM, Caplan D, Chatfield B, Chidekel A, Cho M, Christiani DC, Crapo JD, Crouch J, Daley D, Dang A, Dang H, de Paula A, DeCelie-Germana J, Dozor A, Drumm M, Dyson M, Emerson J, Emond MJ, Ferkol T, Fink R, Foster C, Froh D, Gao L, Gershan W, Gibson RL, Godwin E, Gondor M, Gutierrez H, Hansel NN, Hassoun PM, Hiatt P, Hokanson JE, Howenstine M, Hummer LK, Jamal SM, Kanga J, Kim Y, Knowles MR, Konstan M, Lahiri T, Laird N, Lange C, Lin L, Lin X, Louie TL, Lynch D, Make B, Martin TR, Mathai SC, Mathias RA, McNamara J, McNamara S, Meyers D, Millard S, Mogayzel P, Moss R, Murray T, Nielson D, Noyes B, O'Neal W, Orenstein D, O'Sullivan B, Pace R, Pare P, Parker HW, Passero MA, Perkett E, Prestridge A, Rafaels NM, Ramsey B, Regan E, Ren C, Retsch-Bogart G, Rock M, Rosen A, Rosenfeld M, Ruczinski I, Sanford A, Schaeffer D, Sell C, Sheehan D, Silverman EK, Sin D, Spencer T, Stonebraker J, Tabor HK, Varlotta L, Vergara CI, Weiss R, Wigley F, Wise RA, Wright FA, Wurfel MM, Zanni R, Zou F, Nickerson DA, Rieder MJ, Green P, Shendure J, Akey JM, Bustamante CD, Crosslin DR, Eichler EE, Fox PK, Fu W, Gordon A, Gravel S, Jarvik GP, Johnsen JM, Kan M, Kenny EE, Kidd JM, Lara-Garduno F, Leal SM, Liu DJ, McGee S, O'Connor TD, Paeper B, Robertson PD, Smith JD, Staples JC, Tennessen JA, Turner EH, Wang G, Yi Q, Jackson R, Peters U, Carlson CS, Anderson G, Anton-Culver H, Assimes TL, Auer PL, Beresford S, Bizon C, Black H, Brunner R, Brzyski R, Burwen D, Caan B, Carty CL, Chlebowski R, Cummings S, Curb JD, Eaton CB, Ford L, Franceschini N, Fullerton SM, Gass M, Geller N, Heiss G, Howard BV, Hsu L, Hutter CM, Ioannidis J, Jiao S, Johnson KC, Kooperberg C, Kuller L, LaCroix A, Lakshminarayan K, Lane D, Lasser N, LeBlanc E, Li KP, Limacher M, Lin DY, Logsdon BA, Hutchinson F, Ludlam S, Manson JE, Margolis K, Martin L, McGowan J, Monda KL, Kotchen JM, Nathan L, Ockene J, O'Sullivan MJ, Phillips LS, Prentice RL, Robbins J, Robinson JG, Rossouw JE, Sangi-Haghpeykar H, Sarto GE, Shumaker S, Simon MS, Stefanick ML, Stein E, Tang H, Taylor KC, Thomson CA, Thornton TA, van Horn L, Vitolins M, Wactawski-Wende J, Wallace R, Wassertheil-Smoller S, Zeng D, Applebaum-Bowden D, Feolo M, Gan W, Paltoo DN, Sholinsky P, Sturcke A]] , Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. NATURE 2015;518 (7537):102-+ [PubMed]
Gaudet D, Alexander VJ, Baker BF, Brisson D, Tremblay K, Singleton W, Geary RS, Hughes SG, Viney NJ, Graham MJ, Crooke RM, Witztum JL, Brunzell JD, Kastelein JJP, Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia. NEW ENGL J MED 2015;373 (5):438-447 [PubMed]
Hovingh GK, Kastelein JJP, van Deventer SJH, Round P, Ford J, Saleheen D, Rader DJ, Brewer HB, Barter PJ, Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial. LANCET 2015;386 (9992):452-460 [PubMed]
Hovingh GK, Smits LP, Stefanutti C, Soran H, Kwok S, de Graaf J, Gaudet D, Keyserling CH, Klepp H, Frick J, Paolini JF, Dasseux JL, Kastelein JJP, Stroes ES, The effect of an apolipoprotein A-I-containing high-density lipoprotein-mimetic particle (CER-001) on carotid artery wall thickness in patients with homozygous familial hypercholesterolemia: The Modifying Orphan Disease Evaluation (MODE) study. AM HEART J 2015;169 (5):736-742.e1 [PubMed]
Kastelein JJP, Besseling J, Shah S, Bergeron J, Langslet G, Hovingh GK, Al-Saady N, Koeijvoets M, Hunter J, Johnson-Levonas AO, Fable J, Sapre A, Mitchel Y, Anacetrapib as lipid-modifying therapy in patients with heterozygous familial hypercholesterolaemia (REALIZE): a randomised, double-blind, placebo-controlled, phase 3 study. LANCET 2015;385 (9983):2153-2161 [PubMed]
Kastelein JJP, Ginsberg HN, Langslet G, Hovingh GK, Ceska R, Dufour R, Blom D, Civeira F, Krempf M, Lorenzato C, Zhao J, Pordy R, Baccara-Dinet MT, Gipe DA, Geiger MJ, Farnier M, ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia. EUR HEART J 2015;36 (43):2996-3003 [PubMed]
Kohli P, Waters DD, Nemr R, Arsenault BJ, Messig M, Demicco DA, Laskey R, Kastelein JJP, Risk of New-Onset Diabetes and Cardiovascular Risk Reduction From High-Dose Statin Therapy in Pre-Diabetics and Non-Pre-Diabetics. J AM COLL CARDIOL 2015;65 (4):402-404 [PubMed]
Kootte RS, Smits LP, van der Valk FM, Dasseux JL, Keyserling CH, Barbaras R, Paolini JF, Santos RD, van Dijk TH, Dallinga-van Thie GM, Nederveen AJ, Mulder WJM, Hovingh GK, Kastelein JJP, Groen AK, Stroes ES, Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA. J LIPID RES 2015;56 (3):703-712 [PubMed]
Kusters DM, Caceres M, Coll M, Cuffie C, Gagné C, Jacobson MS, Kwiterovich PO, Lee R, Lowe RS, Massaad R, McCrindle BW, Musliner TA, Triscari J, Kastelein JJP, Efficacy and safety of ezetimibe monotherapy in children with heterozygous familial or nonfamilial hypercholesterolemia. J PEDIATR-US 2015;166 (6):1377-84.e1-3 [PubMed]
Ljunggren SA, Levels JHM, Hovingh K, Holleboom AG, Vergeer M, Argyri L, Gkolfinopoulou C, Chroni A, Sierts JA, Kastelein JJ, Kuivenhoven JA, Lindahl M, Karlsson H, Lipoprotein profiles in human heterozygote carriers of a functional mutation P297S in scavenger receptor class B1. BBA-MOL CELL BIOL L 2015;1851 (12):1587-1595 [PubMed]
Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T, Fall T, Ferreira T, Gustafsson S, Kutalik Z, Luan Ja, Mägi R, Randall JC, Winkler TW, Wood AR, Workalemahu T, Faul JD, Smith JA, Hua Zhao J, Zhao W, Chen J, Fehrmann R, Hedman ÅK, Karjalainen J, Schmidt EM, Absher D, Amin N, Anderson D, Beekman M, Bolton JL, Bragg-Gresham JL, Buyske S, Demirkan A, Deng G, Ehret GB, Feenstra B, Feitosa MF, Fischer K, Goel A, Gong J, Jackson AU, Kanoni S, Kleber ME, Kristiansson K, Lim U, Lotay V, Mangino M, Mateo Leach I, Medina-Gomez C, Medland SE, Nalls MA, Palmer CD, Pasko D, Pechlivanis S, Peters MJ, Prokopenko I, Shungin D, Stančáková A, Strawbridge RJ, Ju Sung Y, Tanaka T, Teumer A, Trompet S, van der Laan SW, van Setten J, van Vliet-Ostaptchouk JV, Wang Z, Yengo L, Zhang W, Isaacs A, Albrecht E, Ärnlöv J, Arscott GM, Attwood AP, Bandinelli S, Barrett A, Bas IN, Bellis C, Bennett AJ, Berne C, Blagieva R, Blüher M, Böhringer S, Bonnycastle LL, Böttcher Y, Boyd HA, Bruinenberg M, Caspersen IH, Ida Chen YD, Clarke R, Daw EW, de Craen AJM, Delgado G, Dimitriou M, Doney ASF, Eklund N, Estrada K, Eury E, Folkersen L, Fraser RM, Garcia ME, Geller F, Giedraitis V, Gigante B, Go AS, Golay A, Goodall AH, Gordon SD, Gorski M, Grabe HJ, Grallert H, Grammer TB, Gräßler J, Grönberg H, Groves CJ, Gusto G, Haessler J, Hall P, Haller T, Hallmans G, Hartman CA, Hassinen M, Hayward C, Heard-Costa NL, Helmer Q, Hengstenberg C, Holmen O, Hottenga JJ, James AL, Jeff JM, Johansson Å, Jolley J, Juliusdottir T, Kinnunen L, Koenig W, Koskenvuo M, Kratzer W, Laitinen J, Lamina C, Leander K, Lee NR, Lichtner P, Lind L, Lindström J, Sin Lo K, Lobbens S, Lorbeer R, Lu Y, Mach F, Magnusson PKE, Mahajan A, McArdle WL, McLachlan S, Menni C, Merger S, Mihailov E, Milani L, Moayyeri A, Monda KL, Morken MA, Mulas A, Müller G, Müller-Nurasyid M, Musk AW, Nagaraja R, Nöthen MM, Nolte IM, Pilz S, Rayner NW, Renstrom F, Rettig R, Ried JS, Ripke S, Robertson NR, Rose LM, Sanna S, Scharnagl H, Scholtens S, Schumacher FR, Scott WR, Seufferlein T, Shi J, Vernon Smith A, Smolonska J, Stanton AV, Steinthorsdottir V, Stirrups K, Stringham HM, Sundström J, Swertz MA, Swift AJ, Syvänen AC, Tan ST, Tayo BO, Thorand B, Thorleifsson G, Tyrer JP, Uh HW, Vandenput L, Verhulst FC, Vermeulen SH, Verweij N, Vonk JM, Waite LL, Warren HR, Waterworth D, Weedon MN, Wilkens LR, Willenborg C, Wilsgaard T, Wojczynski MK, Wong A, Wright AF, Zhang Q, Brennan EP, Choi M, Dastani Z, Drong AW, Eriksson P, Franco-Cereceda A, Gådin JR, Gharavi AG, Goddard ME, Handsaker RE, Huang J, Karpe F, Kathiresan S, Keildson S, Kiryluk K, Kubo M, Lee JY, Liang L, Lifton RP, Ma B, McCarroll SA, McKnight AJ, Min JL, Moffatt MF, Montgomery GW, Murabito JM, Nicholson G, Nyholt DR, Okada Y, Perry JRB, Dorajoo R, Reinmaa E, Salem RM, Sandholm N, Scott RA, Stolk L, Takahashi A, Tanaka T, van't Hooft FM, Vinkhuyzen AAE, Westra HJ, Zheng W, Zondervan KT, Heath AC, Arveiler D, Bakker SJL, Beilby J, Bergman RN, Blangero J, Bovet P, Campbell H, Caulfield MJ, Cesana G, Chakravarti A, Chasman DI, Chines PS, Collins FS, Crawford DC, Cupples LA, Cusi D, Danesh J, de Faire U, den Ruijter HM, Dominiczak AF, Erbel R, Erdmann J, Eriksson JG, Farrall M, Felix SB, Ferrannini E, Ferrières J, Ford I, Forouhi NG, Forrester T, Franco OH, Gansevoort RT, Gejman PV, Gieger C, Gottesman O, Gudnason V, Gyllensten U, Hall AS, Harris TB, Hattersley AT, Hicks AA, Hindorff LA, Hingorani AD, Hofman A, Homuth G, Hovingh GK, Humphries SE, Hunt SC, Hyppönen E, Illig T, Jacobs KB, Jarvelin MR, Jöckel KH, Johansen B, Jousilahti P, Jukema JW, Jula AM, Kaprio J, Kastelein JJP, Keinanen-Kiukaanniemi SM, Kiemeney LA, Knekt P, Kooner JS, Kooperberg C, Kovacs P, Kraja AT, Kumari M, Kuusisto J, Lakka TA, Langenberg C, Le Marchand L, Lehtimäki T, Lyssenko V, Männistö S, Marette A, Matise TC, McKenzie CA, McKnight B, Moll FL, Morris AD, Morris AP, Murray JC, Nelis M, Ohlsson C, Oldehinkel AJ, Ong KK, Madden PAF, Pasterkamp G, Peden JF, Peters A, Postma DS, Pramstaller PP, Price JF, Qi L, Raitakari OT, Rankinen T, Rao DC, Rice TK, Ridker PM, Rioux JD, Ritchie MD, Rudan I, Salomaa V, Samani NJ, Saramies J, Sarzynski MA, Schunkert H, Schwarz PEH, Sever P, Shuldiner AR, Sinisalo J, Stolk RP, Strauch K, Tönjes A, Trégouët DA, Tremblay A, Tremoli E, Virtamo J, Vohl MC, Völker U, Waeber G, Willemsen G, Witteman JC, Zillikens MC, Adair LS, Amouyel P, Asselbergs FW, Assimes TL, Bochud M, Boehm BO, Boerwinkle E, Bornstein SR, Bottinger EP, Bouchard C, Cauchi S, Chambers JC, Chanock SJ, Cooper RS, de Bakker PIW, Dedoussis G, Ferrucci L, Franks PW, Froguel P, Groop LC, Haiman CA, Hamsten A, Hui J, Hunter DJ, Hveem K, Kaplan RC, Kivimaki M, Kuh D, Laakso M, Liu Y, Martin NG, März W, Melbye M, Metspalu A, Moebus S, Munroe PB, Njølstad I, Oostra BA, Palmer CNA, Pedersen NL, Perola M, Pérusse L, Peters U, Power C, Quertermous T, Rauramaa R, Rivadeneira F, Saaristo TE, Saleheen D, Sattar N, Schadt EE, Schlessinger D, Slagboom PE, Snieder H, Spector TD, Thorsteinsdottir U, Stumvoll M, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Walker M, Wallaschofski H, Wareham NJ, Watkins H, Weir DR, Wichmann HE, Wilson JF, Zanen P, Borecki IB, Deloukas P, Fox CS, Heid IM, O'Connell JR, Strachan DP, Stefansson K, van Duijn CM, Abecasis GR, Franke L, Frayling TM, McCarthy MI, Visscher PM, Scherag A, Willer CJ, Boehnke M, Mohlke KL, Lindgren CM, Beckmann JS, Barroso I, North KE, Ingelsson E, Hirschhorn JN, Loos RJF, Speliotes EK [Contributors: Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, Stirrups K, König IR, Cazier JB, Johansson Å, Hall AS, Lee JY, Willer CJ, Chambers JC, Esko T, Folkersen L, Goel A, Grundberg E, Havulinna AS, Ho WK, Hopewell JC, Eriksson N, Kleber ME, Kristiansson K, Lundmark P, Lyytikäinen LP, Rafelt S, Shungin D, Strawbridge RJ, Thorleifsson G, Tikkanen E, van Zuydam N, Voight BF, Waite LL, Zhang W, Ziegler A, Absher D, Altshuler D, Balmforth AJ, Barroso I, Braund PS, Burgdorf C, Claudi-Boehm S, Cox D, Dimitriou M, Do R, Doney ASF, El Mokhtari N, Eriksson P, Fischer K, Fontanillas P, Franco-Cereceda A, Gigante B, Groop L, Gustafsson S, Hager J, Hallmans G, Han BG, Hunt SE, Kang HM, Illig T, Kessler T, Knowles JW, Kolovou G, Kuusisto J, Langenberg C, Langford C, Leander K, Lokki ML, Lundmark A, McCarthy MI, Meisinger C, Melander O, Mihailov E, Maouche S, Morris AD, Müller-Nurasyid M, Nikus K, Peden JF, Rayner NW, Rasheed A, Rosinger S, Rubin D, Rumpf MP, Schäfer A, Sivananthan M, Song C, Stewart AFR, Tan ST, Thorgeirsson G, van der Schoot CE, Wagner PJ, Wells GA, Wild PS, Tsun-Po Y, Amouyel P, Arveiler D, Basart H, Boehnke M, Boerwinkle E, Brambilla P, Cambien F, Cupples AL, de Faire U, Dehghan A, Diemert P, Epstein SE, Evans A, Ferrario MM, Ferrières J, Gauguier D, Go AS, Goodall AH, Gudnason V, Hazen SL, Holm H, Iribarren C, Jang Y, Kähönen M, Kee F, Kim HS, Klopp N, Koenig W, Kratzer W, Kuulasmaa K, Laakso M, Laaksonen R, Lee JY, Lind L, Ouwehand WH, Parish S, Park JE, Pedersen NL, Peters A, Quertermous T, Rader DJ, Salomaa V, Schadt E, Shah SH, Sinisalo J, Stark K, Stefansson K, Trégouët DA, Virtamo J, Wallentin L, Wareham N, Zimmermann ME, Nieminen MS, Hengstenberg C, Sandhu MS, Pastinen T, Syvänen AC, Hovingh GK, Dedoussis G, Franks PW, Lehtimäki T, Metspalu A, Zalloua PA, Siegbahn A, Schreiber S, Ripatti S, Blankenberg SS, Perola M, Clarke R, Boehm BO, O'Donnell C, Reilly MP, März W, Collins R, Kathiresan S, Hamsten A, Kooner JS, Thorsteinsdottir U, Danesh J, Palmer CNA, Roberts R, Watkins H, Schunkert H, Samani NJ, Pattaro C, Köttgen A, Teumer A, Garnaas M, Böger CA, Fuchsberger C, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O'Seaghdha CM, Glazer N, Isaacs A, Liu CT, Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Johnson AD, Gierman HJ, Feitosa M, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Tönjes A, Chouraki V, Holliday EG, Sorice R, Kutalik Z, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Kollerits B, Pistis G, Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Schmidt H, Cavalieri M, Rao M, Hu FB, Demirkan A, Oostra BA, de Andrade M, Turner ST, Ding J, Andrews JS, Freedman BI, Döring A, Wichmann HE, Kolcic I, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Endlich K, Ernst F, Homuth G, Kroemer HK, Nauck M, Stracke S, Völker U, Völzke H, Kovacs P, Stumvoll M, Mägi R, Hofman A, Uitterlinden AG, Rivadeneira F, Aulchenko YS, Polasek O, Hastie N, Vitart V, Helmer C, Wang JJ, Ruggiero D, Bergmann S, Viikari J, Nikopensius T, Province M, Ketkar S, Colhoun H, Doney A, Robino A, Giulianini F, Krämer BK, Portas L, Ford I, Buckley BM, Adam M, Thun GA, Paulweber B, Haun M, Sala C, Metzger M, Mitchell P, Ciullo M, Kim SK, Vollenweider P, Raitakari O, Palmer C, Gasparini P, Pirastu M, Jukema JW, Probst-Hensch NM, Kronenberg F, Toniolo D, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Siscovick DS, van Duijn CM, Borecki I, Kardia SLR, Liu Y, Curhan GC, Rudan I, Gyllensten U, Wilson JF, Franke A, Pramstaller PP, Rettig R, Prokopenko I, Witteman JCM, Hayward C, Ridker P, Parsa A, Bochud M, Heid IM, Goessling W, Chasman DI, Kao WHL, Fox CS, de Boer IH, Glazer NL, Peralta CA, Kutalik Z, Luan Ja, Zhao JH, Akylbekova E, Kramer H, van der Harst P, Arking DE, Franceschini N, Egan J, Hernandez D, Reilly M, Townsend RR, Lumley T, Psaty BM, Kestenbaum B, Haritunians T, Waeber G, Mooser V, Waterworth D, Florez JC, Meigs JB, Lu X, Leak TS, Aasarød K, Skorpen F, Baumert J, Devuyst O, Mychaleckyj JC, Bakker SJL, Kedenko L, Coassin S, Hastie ND, Curhan G, Ärnlöv J, Hallan S, Navis G, Shlipak MG, Bull SB, Paterson AD, Wareham NJ, Loos RJF, Rotter JI, Cupples LA, Beckmann JS, Dreisbach AW, Kao WHL, Anderson CA, Gordon SD, Guo Q, Henders AK, Lambert A, Lee SH, Kraft P, Kennedy SH, Macgregor S, Martin NG, Missmer SA, Montgomery GW, Morris AP, Nyholt DR, Painter JN, Roseman F, Treloar SA, Visscher PM, Wallace L, Zondervan KT, Sandholm N, Salem RM, McKnight AJ, Brennan EP, Forsblom C, Isakova T, McKay GJ, Williams WW, Sadlier DM, Mäkinen VP, Swan EJ, Palmer C, Boright AP, Ahlqvist E, Deshmukh HA, Keller BJ, Huang H, Ahola A, Fagerholm E, Gordin D, Harjutsalo V, He B, Heikkilä O, Hietala K, Kytö J, Lahermo P, Lehto M, Österholm AM, Parkkonen M, Pitkäniemi J, Rosengård-Bärlund M, Saraheimo M, Sarti C, Söderlund J, Soro-Paavonen A, Syreeni A, Thorn LM, Tikkanen H, Tolonen N, Tryggvason K, Tuomilehto J, Wadén J, Gill GV, Prior S, Guiducci C, Mirel DB, Taylor A, Hosseini M, Parving HH, Rossing P, Tarnow L, Ladenvall C, Alhenc-Gelas F, Lefebvre P, Rigalleau V, Roussel R, Tregouet DA, Maestroni A, Maestroni S, Falhammar H, Gu T, Möllsten A, Cimponeriu D, Mihai I, Mota M, Mota E, Serafinceanu C, Stavarachi M, Hanson RL, Nelson RG, Kretzler M, Colhoun HM, Panduru NM, Gu HF, Brismar K, Zerbini G, Hadjadj S, Marre M, Lajer M, Waggott D, Savage DA, Bain SC, Martin F, Hirschhorn JN, Godson C, Groop PH, Maxwell AP, Schmidt EM, Sengupta S, Peloso GM, Ganna A, Chen J, Buchkovich ML, Mora S, Bragg-Gresham JL, Chang HY, Demirkan A, den Hertog HM, Donnelly LA, Ehret GB, Feitosa MF, Ferreira T, Fraser RM, Freitag DF, Gurdasani D, Heikkilä K, Hyppönen E, Jackson AU, Johnson T, Kaakinen M, Kettunen J, Li X, Magnusson PKE, Mangino M, Montasser ME, Nolte IM, Palmer CD, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Sidore C, Surakka I, Teslovich TM, van den Herik EG, Volcik KA, Wong A, Wu Y, Asiki G, Been LF, Bolton JL, Bonnycastle LL, Burnett MS, Cesana G, Doring A, Elliott P, Eyjolfsson GI, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hartikainen AL, Hicks AA, Hung YJ, Jones MR, Kaleebu P, Kastelein JJP, Khaw KT, Kim E, Komulainen P, Kumari M, Lehtimaki T, Lin SY, Lindstrom J, Mach F, McArdle WL, Muller G, Nagaraja R, Narisu N, Nieminen TVM, Nsubuga RN, Olafsson I, Ong KK, Palotie A, Papamarkou T, Pomilla C, Pouta A, Ridker PM, Ruokonen A, Samani N, Scharnagl H, Seeley J, Silander K, Stančáková A, Swift AJ, Tiret L, van Pelt LJ, Vedantam S, Wainwright N, Wijmenga C, Willemsen G, Wilsgaard T, Young EH, Adair LS, Bandinelli S, Bennett F, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier M, Chakravarti A, Chen YDI, Collins FS, Cooper RS, Feranil AB, Ferrieres J, Freimer NB, Gieger C, Groop LC, Hingorani A, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Jarvelin MR, Jula A, Kaprio J, Kesäniemi A, Kivimaki M, Koudstaal PJ, Krauss RM, Kuh D, Kyvik KO, Lakka TA, Lindgren CM, McKenzie CA, Meneton P, Moilanen L, Munroe PB, Njølstad I, Power C, Price JF, Rauramaa R, Sanghera DK, Saramies J, Schwarz PEH, Sheu WHH, Spector TD, Strachan DP, Tayo BO, Tremoli E, Uusitupa M, Whitfield JB, Wolffenbuttel BHR, Ordovas JM, Rich SS, Mohlke KL, Abecasis GR, Abecasis G, Caulfield M, Chasman D, Ehret G, Johnson A, Johnson L, Larson M, Levy D, Munroe P, Newton-Cheh C, O'Reilly P, Palmas W, Psaty B, Rice K, Smith A, Snider H, Tobin M, van Duijn C, Verwoert G, Rice KM, Tobin MD, Verwoert GC, Pihur V, O'Reilly PF, Amin N, Launer L, Aulchenko Y, Heath S, Sõber S, Arora P, Zhang F, Lucas G, Milaneschi Y, Parker AN, Fava C, Fox ER, Go MJ, Kao WHL, Sjögren M, Vinay DG, Alexander M, Tabara Y, Shaw-Hawkins S, Whincup PH, Shi G, Tayo B, Seielstad M, Sim X, Nguyen KDH, Matullo G, Gaunt TR, Onland-Moret NC, Cooper MN, Platou CGP, Org E, Hardy R, Dahgam S, Palmen J, Kuznetsova T, Uiterwaal CSPM, Adeyemo A, Ludwig B, Tomaszewski M, Tzoulaki I, Palmer ND, Garcia M, Chang YPC, Steinle NI, Grobbee DE, Kardia SL, Morrison AC, Najjar S, Hadley D, Brown MJ, Connell JM, Hingorani AD, Day INM, Lawlor DA, Beilby JP, Lawrence RW, Ongen H, Li Y, Young JH, Bis JC, Lee NR, Bolton JAH, Chaturvedi N, Frayling TM, Islam M, Jafar TH, Kulkarni SR, Grässler J, Howard P, Guarrera S, Ricceri F, Emilsson V, Plump A, Weder AB, Sun YV, Bergman RN, Scott LJ, Stringham HM, Peltonen L, Vartiainen E, Brand SM, Staessen JA, Wang TJ, Burton PR, Artigas MS, Dong Y, Snieder H, Wang X, Zhu H, Lohman KK, Rudock ME, Heckbert SR, Smith NL, Wiggins KL, Doumatey A, Shriner D, Veldre G, Viigimaa M, Kinra S, Prabhakaran D, Tripathy V, Langefeld CD, Rosengren A, Thelle DS, Corsi AM, Singleton A, Forrester T, Hilton G, Salako T, Iwai N, Kita Y, Ogihara T, Ohkubo T, Okamura T, Ueshima H, Umemura S, Eyheramendy S, Meitinger T, Cho YS, Kim HL, Scott J, Sehmi JS, Hedblad B, Nilsson P, Smith GD, Raffel LJ, Yao J, O'Donnell C, Schwartz SM, Ikram MA, Longstreth WT Jr, Mosley TH, Seshadri S, Shrine NRG, Wain LV, Morken MA, Laitinen J, Zitting P, Cooper JA, van Gilst WH, Janipalli CS, Mani KR, Yajnik CS, Mattace-Raso FUS, Lakatta EG, Orru M, Scuteri A, Ala-Korpela M, Kangas AJ, Soininen P, Tukiainen T, Würtz P, Ong RTH, Dörr M, Galan P, Hercberg S, Lathrop M, Zelenika D, Zhai G, Meschia JF, Nalls MA, Sharma P, Terzic J, Kumar MJK, Denniff M, Zukowska-Szczechowska E, Wagenknecht LE, Fowkes FGR, Charchar FJ, Guo X, Rotimi C, Bots ML, Brand E, Talmud PJ, Nyberg F, Laan M, Palmer LJ, van der Schouw YT, Casas JP, Vineis P, Ganesh SK, Wong TY, Tai ES, Rao DC, Morris RW, Dominiczak AF, Marmot MG, Miki T, Chandak GR, Zhu X, Gyllensten UB, Elosua R, Soranzo N, Sijbrands EJG, Uda M, Vasan RS, Larson MG, Järvelin MR, Caulfield MJ, Alizadeh BZ, de Boer RA, Boezen HM, Bruinenberg M, Franke L, Hillege HL, van der Klauw MM, Ormel J, Postma DS, Rosmalen JGM, Slaets JP, Stolk RP, Scott RA, Lagou V, Welch RP, Wheeler E, Rehnberg E, Rasmussen-Torvik LJ, Yengo L, Lecoeur C, Johnson PCD, Mahajan A, Verweij N, Hottenga JJ, Sennblad B, Salo P, Timpson NJ, Evans DM, St Pourcain B, Hui J, Bielak LF, Zhao W, Horikoshi M, Navarro P, Esko T, Fall T, Raychaudhuri S, Chen H, Rayner NW, Robertson N, Rybin D, Willems SM, Chines PS, Kang HM, Song K, An P, Marullo L, Jansen H, Oldehinkel AJ, Pankow JS, North KE, Forouhi NG, Edkins S, Varga TV, Oksa H, Antonella M, Kong A, Herder C, Antti J, Small K, Miljkovic I, Atalay M, Kiess W, James AL, Smit JH, Campbell S, Fowkes GR, Lindström J, Basart HV, Rathmann W, Maerz W, Province MA, Waterworth DM, Watanabe RM, de Geus EJC, Penninx BW, Dedoussis GV, Toenjes A, Peyser PA, Körner A, Keinanen-Kiukaanniemi SM, Saaristo TE, Dupuis J, Sattar N, Cucca F, Balkau B, Froguel P, Bouatia-Naji N, Purcell S, Musunuru K, Ardissino D, Mannucci PM, Anand S, Engert JC, Morgan T, Spertus JA, Stoll M, Girelli D, McKeown PP, Patterson CC, O'Donnell CJ, Merlini PA, Berzuini C, Bernardinelli L, Peyvandi F, Tubaro M, Celli P, Ferrario M, Fetiveau R, Marziliano N, Casari G, Galli M, Ribichini F, Rossi M, Bernardi F, Zonzin P, Piazza A, Yee J, Friedlander Y, Marrugat J, Subirana I, Sala J, Ramos R, Williams G, Nathan DM, MacRae CA, Berglund G, Asselta R, Duga S, Spreafico M, Daly MJ, Nemesh J, Korn JM, McCarroll SA, Surti A, Gianniny L, Mirel D, Parkin M, Burtt N, Gabriel SB, Wright BJ, Ball SG, Schunkert IH, Linsel-Nitschke P, Lieb W, Fischer M, Grosshennig A, Preuss M, Ouwehand W, Scholz M, Goodall A, Li M, Chen Z, Wilensky R, Matthai W, Qasim A, Hakonarson HH, Devaney J, Burnett MS, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Knouff CW, Walker MC, Scheffold T, Berger K, Huge A, Martinelli N, Olivieri O, Corrocher R, Hólm H, Xie C, Siscovick D, Ahmadi KR, Ainali C, Barrett A, Bataille V, Bell JT, Buil A, Dermitzakis ET, Dimas AS, Durbin R, Glass D, Hassanali N, Hedman ÅK, Ingle C, Keildson S, Knowles D, Krestyaninova M, Lowe CE, Meduri E, di Meglio P, Min JL, Montgomery SB, Nestle FO, Nica AC, Nisbet J, O'Rahilly S, Parts L, Potter S, Sekowska M, Shin SY, Small KS, Surdulescu G, Travers ME, Tsaprouni L, Tsoka S, Wilk A, Yang TP, Matise T, Buyske S, Higashio J, Williams R, Nato A, Ambite JL, Deelman E, Manolio T, Hindorff L, Heiss G, Taylor K, Avery C, Graff M, Lin D, Quibrera M, Cochran B, Kao L, Umans J, Cole S, MacCluer J, Person S, Pankow J, Gross M, Fornage M, Durda P, Jenny N, Patsy B, Arnold A, Buzkova P, Crawford D, Haines J, Murdock D, Glenn K, Brown-Gentry K, Thornton-Wells T, Dumitrescu L, Jeff J, Bush WS, Mitchell SL, Goodloe R, Wilson S, Boston J, Malinowski J, Restrepo N, Oetjens M, Fowke J, Zheng W, Spencer K, Ritchie M, Pendergrass S, Le Marchand L, Wilkens L, Park L, Tiirikainen M, Kolonel L, Lim U, Cheng I, Wang H, Shohet R, Haiman C, Stram D, Henderson B, Monroe K, Schumacher F, Kooperberg C, Peters U, Anderson G, Carlson C, Prentice R, LaCroix A, Wu C, Carty C, Gong J, Rosse S, Young A, Haessler J, Kocarnik J, Lin Y, Jackson R, Duggan D, Kuller L, Stolk L, Perry JRB, He C, Sulem P, Barbalic M, Broer L, Byrne EM, Gudbjartsson DF, McArdle PF, Porcu E, van Wingerden S, Zhuang WV, Albrecht E, Lauc LB, Broekmans FJ, Burri A, Chanock SJ, Chen C, Corre T, Coviello AD, D'Adamo P, Davies G, Deary IJ, Dedoussis GVZ, Deloukas P, Ebrahim S, Eriksson JG, Fauser BCJM, Ferreli L, Folsom AR, Garcia ME, Hall P, Haller T, Hankinson SE, Hass M, Heath AC, Janssens ACJW, Karasik D, Keyzer J, Kiel DP, Lahti J, Lai S, Laisk T, Laven JSE, Liu J, Lopez LM, Louwers YV, Marongiu M, Klaric IM, Masciullo C, McKnight B, Medland SE, Melzer D, Newman AB, Paré G, Peeters PHM, Plump AS, Pop VJM, Räikkönen K, Salumets A, Smith JA, Stacey SN, Starr JM, Stathopoulou MG, Styrkarsdottir U, Tenesa A, Thorand B, Tryggvadottir L, Tsui K, van Dam RM, van Gils CH, van Nierop P, Vink JM, Voorhuis M, Waeber G, Wallaschofski H, Wichmann HE, Widen E, Wijnands-van Gent CJM, Yerges-Armstrong LM, Zgaga L, Zillikens MC, Zygmunt M, Arnold AM, Buring JE, Crisponi L, Demerath EW, Hunter DJ, Schlessinger D, Streeten EA, Uitterlinden AG, Murray A, Murabito JM, Visser JA, Lunetta KL, Elks CE, Cousminer DL, Feenstra B, Koller DL, Lin P, McArdle PF, van Wingerden SW, Smith EN, Ulivi S, Warrington NM, Alavere H, Barroso I, Berenson GS, Blackburn H, Busonero F, Chen W, Couper D, Easton DF, Eriksson J, Foroud T, Geller F, Hernandez DG, Kilpeläinen 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Marx N, Rosenstock J, Kahn SE, Zinman B, Kastelein JJ, Lachin JM, Espeland MA, Bluhmki E, Mattheus M, Ryckaert B, Patel S, Johansen OE, Woerle HJ, Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (CAROLINA (R)). DIABETES VASC DIS RE 2015;12 (3):164-174 [PubMed]
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Moriarty PM, Thompson PD, Cannon CP, Guyton JR, Bergeron J, Zieve FJ, Bruckert E, Jacobson TA, Kopecky SL, Baccara-Dinet MT, Du Y, Pordy R, Gipe DA [Contributors: Drexel H, Kaser S, Toplak H, Baass A, Bergeron J, Gaudet D, Bruckert E, Farnier M, Krempf M, Moulin P, Serusclat P, Cohen H, Gavish D, Hussein O, Maislos M, Schurr D, Arca M, Averna M, Pozzi C, Balsamo C, Heggen E, Langslet G, Al-Bahrani A, Blagden M, O'Kane M, Reynolds T, Viljoen A, Andersen J, Awasty V, Bayron C, Bestermann W, Bolster E, deGoma E, Dunn F, Duprez D, Elam M, El Shahawy M, Faillace R, Freeman M, Goyal N, Guyton J, Hemphill L, Huffman C, Jain V, Kopecky S, Koren M, Lepor N, Lesko M, Linton M, Loh I, Malik A, Mascarenhas V, Moriarty P, Mulford M, Muse D, O'dea D, Shaoulian E, Smith D, Stearns P, Thompson P, Toth P, Turner T, Vardi G, Voyce S, Weinstein D, Weiss R, Zieve F, Ginsberg H, Robinson JG, Rader DJ, Cannon CP, Colhoun HM, Kastelein JJP, Olsson A, Waters D, Larrey D, Rosenson RS, Patriarca PA, Molenberghs G, Tricoci P, Mahaffey KW, Lopes RD, Shah BR, Mehta RH, Roe MT, Eapen Z, Armaganijan L, Bertolami A, Leonardi S, Kolls BJ, Jordan JD, Ducrocq G, Puymirat E, Mathews R, Alexander K, Melloni C]] , Efficacy and safety of alirocumab vs ezetimibe in statin-intolerant patients, with a statin rechallenge arm: The ODYSSEY ALTERNATIVE randomized trial. J CLIN LIPIDOL 2015;9 (6):758-769 [PubMed]
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Maillard M, McArdle WL, McKenzie CA, McLachlan S, McLaren PJ, Menni C, Merger S, Milani L, Moayyeri A, Monda KL, Morken MA, Müller G, Müller-Nurasyid M, Musk AW, Narisu N, Nauck M, Nolte IM, Nöthen MM, Oozageer L, Pilz S, Rayner NW, Renstrom F, Robertson NR, Rose LM, Roussel R, Sanna S, Scharnagl H, Scholtens S, Schumacher FR, Schunkert H, Scott RA, Sehmi J, Seufferlein T, Shi J, Silventoinen K, Smit JH, Smith AV, Smolonska J, Stanton AV, Stirrups K, Stott DJ, Stringham HM, Sundström J, Swertz MA, Syvänen AC, Tayo BO, Thorleifsson G, Tyrer JP, van Dijk S, van Schoor NM, van der Velde N, van Heemst D, van Oort FVA, Vermeulen SH, Verweij N, Vonk JM, Waite LL, Waldenberger M, Wennauer R, Wilkens LR, Willenborg C, Wilsgaard T, Wojczynski MK, Wong A, Wright AF, Zhang Q, Arveiler D, Bakker SJL, Beilby J, Bergman RN, Bergmann S, Biffar R, Blangero J, Boomsma I, Bornstein SR, Bovet P, Brambilla P, Brown MJ, Campbell H, Caulfield MJ, Chakravarti A, Collins R, Collins FS, Crawford DC, Cupples 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Saramies J, Sarzynski MA, Schwarz PEH, Sebert S, Sever P, Shuldiner AR, Sinisalo J, Steinthorsdottir V, Stolk RP, Tardif JC, Tönjes A, Tremblay A, Tremoli E, Virtamo J, Vohl MC, Amouyel P, Asselbergs FW, Assimes TL, Bochud M, Boehm BO, Boerwinkle E, Bottinger EP, Bouchard C, Cauchi S, Chambers JC, Chanock SJ, Cooper RS, de Bakker PIW, Dedoussis G, Ferrucci L, Franks PW, Froguel P, Groop LC, Haiman CA, Hamsten A, Hayes MG, Hui J, Hunter DJ, Hveem K, Jukema JW, Kaplan RC, Kivimaki M, Kuh D, Laakso M, Liu Y, Martin NG, März W, Melbye M, Moebus S, Munroe PB, Njølstad I, Oostra BA, Palmer CNA, Pedersen NL, Perola M, Pérusse L, Peters U, Powell JE, Power C, Quertermous T, Rauramaa R, Reinmaa E, Ridker PM, Rivadeneira F, Rotter JI, Saaristo TE, Saleheen D, Schlessinger D, Slagboom PE, Snieder H, Spector TD, Strauch K, Stumvoll M, Tuomilehto J, Uusitupa M, van der Harst P, Völzke H, Walker M, Wareham NJ, Watkins H, Wichmann HE, Wilson JF, Zanen P, Deloukas P, Heid IM, Lindgren CM, Mohlke KL, 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Saleheen D, Scott R, Javad S, Zhao W, Rodrigues A, Picataggi A, Lukmanova D, Mucksavage ML, Luben R, Billheimer J, Kastelein JJP, Boekholdt SM, Khaw KT, Wareham N, Rader DJ, Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study. LANCET DIABETES ENDO 2015;3 (7):507-513 [PubMed]
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M, Pérusse L, Peters U, Power C, Quertermous T, Rauramaa R, Rivadeneira F, Saaristo TE, Saleheen D, Sinisalo J, Slagboom PE, Snieder H, Spector TD, Thorsteinsdottir U, Stumvoll M, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Veronesi G, Walker M, Wareham NJ, Watkins H, Wichmann HE, Abecasis GR, Assimes TL, Berndt SI, Boehnke M, Borecki IB, Deloukas P, Franke L, Frayling TM, Groop LC, Hunter DJ, Kaplan RC, O'Connell JR, Qi L, Schlessinger D, Strachan DP, Stefansson K, van Duijn CM, Willer CJ, Visscher PM, Yang J, Hirschhorn JN, Zillikens MC, McCarthy MI, Speliotes EK, North KE, Fox CS, Barroso I, Franks PW, Ingelsson E, Heid IM, Loos RJF, Cupples LA, Morris AP, Lindgren CM, Mohlke KL [Contributors: Dastani Z, Hivert MF, Timpson N, Perry JRB, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikainen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, Beekman M, Coassin S, Lohman K, Qi L, Kanoni S, Pankow JS, Uh HW, Wu Y, Bidulescu A, Rasmussen-Torvik LJ, 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J, Richards JB, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, Stirrups K, König IR, Cazier JB, Johansson Å, Hall AS, Lee JY, Willer CJ, Chambers JC, Esko T, Folkersen L, Goel A, Grundberg E, Havulinna AS, Ho WK, Hopewell JC, Eriksson N, Kleber ME, Lundmark P, Lyytikäinen LP, Rafelt S, Shungin D, Strawbridge RJ, Thorleifsson G, Tikkanen E, van Zuydam N, Voight BF, Waite LL, Zhang W, Ziegler A, Absher D, Altshuler D, Balmforth AJ, Barroso I, Braund PS, Burgdorf C, Claudi-Boehm S, Cox D, Dimitriou M, Do R, Doney ASF, El Mokhtari N, Eriksson P, Fischer K, Fontanillas P, Franco-Cereceda A, Gigante B, Groop L, Gustafsson S, Hager J, Hallmans G, Han BG, Hunt SE, Kang HM, Illig T, Kessler T, Knowles JW, Kolovou G, Kuusisto J, Langford C, Leander K, Lokki ML, Lundmark A, McCarthy MI, Meisinger C, Melander O, Mihailov E, Maouche S, Morris AD, Müller-Nurasyid M, Nikus K, Peden JF, Rayner NW, Rasheed A, Rosinger S, Rubin D, Rumpf MP, Schäfer A, Sivananthan M, Song C, Stewart AFR, Tan ST, Thorgeirsson G, van der Schoot CE, Wagner PJ, Wells GA, Wild PS, Yang TP, Amouyel P, Arveiler D, Basart H, Boehnke M, Boerwinkle E, Brambilla P, Cambien F, Cupples AL, de Faire U, Dehghan A, Diemert P, Epstein SE, Evans A, Ferrario MM, Ferrières J, Gauguier D, Go AS, Goodall AH, Gudnason V, Hazen SL, Holm H, Iribarren C, Jang Y, Kee F, Kim HS, Koenig W, Kratzer W, Kuulasmaa K, Laakso M, Laaksonen R, Lee JY, Lind L, Ouwehand WH, Parish S, Park JE, Pedersen NL, Peters A, Quertermous T, Rader DJ, Schadt E, Shah SH, Sinisalo J, Stark K, Stefansson K, Trégouët DA, Virtamo J, Wallentin L, Wareham N, Zimmermann ME, Nieminen MS, Hengstenberg C, Sandhu MS, Pastinen T, Syvänen AC, Hovingh GK, Dedoussis G, Franks PW, Metspalu A, Zalloua PA, Siegbahn A, Schreiber S, Ripatti S, Blankenberg SS, Clarke R, Boehm BO, O'Donnell C, Reilly MP, März W, Collins R, Kathiresan S, Hamsten A, Kooner JS, Thorsteinsdottir U, Danesh J, Palmer CNA, Roberts R, Watkins H, 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JJ, Ruggiero D, Bergmann S, Nikopensius T, Province M, Ketkar S, Colhoun H, Doney A, Robino A, Giulianini F, Krämer BK, Portas L, Ford I, Buckley BM, Adam M, Thun GA, Sala C, Metzger M, Mitchell P, Ciullo M, Kim SK, Palmer C, Gasparini P, Pirastu M, Jukema JW, Probst-Hensch NM, Toniolo D, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, van Duijn CM, Borecki I, Kardia SLR, Curhan GC, Rudan I, Gyllensten U, Wilson JF, Franke A, Rettig R, Prokopenko I, Witteman JCM, Hayward C, Ridker P, Parsa A, Bochud M, Goessling W, Chasman DI, Kao WHL, Fox CS, de Boer IH, Glazer NL, Peralta CA, Kutalik Z, Luan Ja, Zhao JH, Akylbekova E, Kramer H, van der Harst P, Arking DE, Franceschini N, Egan J, Hernandez D, Reilly M, Townsend RR, Lumley T, Kestenbaum B, Haritunians T, Waeber G, Mooser V, Waterworth D, Lu X, Leak TS, Aasarød K, Skorpen F, Baumert J, Devuyst O, Mychaleckyj JC, Bakker SJL, Hastie ND, Curhan G, Ärnlöv J, Hallan S, Navis G, Shlipak MG, Bull SB, Paterson AD, Rotter JI, Cupples LA, Beckmann JS, Dreisbach AW, Kao WHL, Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, Oei L, Albagha OME, Amin N, Kemp JP, Koller DL, Minster RL, Moayyeri A, Vandenput L, Willner D, Xiao SM, Yerges-Armstrong LM, Zheng HF, Alonso N, Eriksson J, Kammerer CM, Kaptoge SK, Leo PJ, Wilson SG, Aalto V, Alen M, Aragaki AK, Center JR, Dailiana Z, Duggan DJ, Garcia-Giralt N, Giroux S, Hocking LJ, Husted LB, Jameson KA, Khusainova R, Kim GS, Kooperberg C, Koromila T, Kruk M, Laaksonen M, LaCroix AZ, Lee SH, Leung PC, Lewis JR, Masi L, Mencej-Bedrac S, Nguyen TV, Nogues X, Patel MS, Prezelj J, Rose LM, Scollen S, Siggeirsdottir K, Svensson O, Trummer O, van Schoor NM, Woo J, Zhu K, Balcells S, Brandi ML, Cheng S, Christiansen C, Cooper C, Frost M, Goltzman D, González-Macías J, Karlsson M, Khusnutdinova E, Koh JM, Kollia P, Langdahl BL, Leslie WD, Lips P, Ljunggren Ö, Lorenc RS, Marc J, Mellström D, Obermayer-Pietsch B, Olmos JM, Pettersson-Kymmer U, Reid DM, Riancho JA, Ridker PM, 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Stitziel NO, Peloso GM, Abifadel M, Cefalu AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Rabès JP, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M, Risman M, deo R, Ruel I, Shendure J, Nickerson DA, Wilson JG, Rich SS, Gupta N, Farlow DN, Neale BM, Daly MJ, Kane JP, Freeman MW, Genest J, Rader DJ, Mabuchi H, Kastelein JJP, Hovingh GK, Averna MR, Gabriel S, Boileau C, Kathiresan S, Exome sequencing in suspected monogenic dyslipidemias. CIRC-CARDIOVASC GENE 2015;8 (2):343-350 [PubMed]
Stoekenbroek RM, Kastelein JJP, Huijgen R, PCSK9 inhibition: the way forward in the treatment of dyslipidemia. BMC MED 2015;13 (1):258 [PubMed]
Vallejo-Vaz AJ, Kondapally Seshasai SR, Cole D, Hovingh GK, Kastelein JJP, Mata P, Raal FJ, Santos RD, Soran H, Watts GF, Abifadel M, Aguilar-Salinas CA, Akram A, Alnouri F, Alonso R, Al-Rasadi K, Banach M, Bogsrud MP, Bourbon M, Bruckert E, Car J, Corral P, Descamps O, Dieplinger H, Durst R, Freiberger T, Gaspar IM, Genest J, Harada-Shiba M, Jiang L, Kayikcioglu M, Lam CSP, Latkovskis G, Laufs U, Liberopoulos E, Nilsson L, Nordestgaard BG, O'Donoghue JM, Sahebkar A, Schunkert H, Shehab A, Stoll M, Su TC, Susekov A, Widén E, Catapano AL, Ray KK, Familial hypercholesterolaemia: A global call to arms. ATHEROSCLEROSIS 2015;243 (1):257-259 [PubMed]
van Wijk DF, Strang AC, Duivenvoorden R, Enklaar DJF, Zwinderman AH, van der Geest RJ, Kastelein JJP, de Groot E, Stroes ESG, Nederveen AJ, Increasing the Spatial Resolution of 3T Carotid MRI Has No Beneficial Effect for Plaque Component Measurement Reproducibility. PLOS ONE 2015;10 (7):e0130878 [PubMed]
Versmissen J, Oosterveer DM, Yazdanpanah M, Dehghan A, Hólm H, Erdman J, Aulchenko YS, Thorleifsson G, Schunkert H, Huijgen R, Vongpromek R, Uitterlinden AG, Defesche JC, van Duijn CM, Mulder M, Dadd T, Karlsson HD, Ordovas J, Kindt I, Jarman A, Hofman A, van Vark-van der Zee L, Blommesteijn-Touw AC, Kwekkeboom J, Liem AH, van der Ouderaa FJ, Calandra S, Bertolini S, Averna M, Langslet G, Ose L, Ros E, Almagro F, de Leeuw PW, Civeira F, Masana L, Pintó X, Simoons ML, Schinkel AFL, Green MR, Zwinderman AH, Johnson KJ, Schaefer A, Neil A, Witteman JCM, Humphries SE, Kastelein JJP, Sijbrands EJG, Identifying genetic risk variants for coronary heart disease in familial hypercholesterolemia: an extreme genetics approach. EUR J HUM GENET 2015;23 (3):381-387 [PubMed]
Watts GF, Gidding S, Wierzbicki AS, Toth PP, Alonso R, Brown WV, Bruckert E, Defesche J, Lin KK, Livingston M, Mata P, Parhofer KG, Raal FJ, Santos RD, Sijbrands EJG, Simpson WG, Sullivan DR, Susekov AV, Tomlinson B, Wiegman A, Yamashita S, Kastelein JJP, Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation. EUR J PREV CARDIOL 2015;22 (7):849-854 [PubMed]
Arsenault BJ, Barter P, Demicco DA, Bao W, Preston GM, LaRosa JC, Grundy SM, Deedwania P, Greten H, Wenger NK, Shepherd J, Waters DD, Kastelein JJP, Prediction of cardiovascular events in statin-treated stable coronary patients of the treating to new targets randomized controlled trial by lipid and non-lipid biomarkers. PLOS ONE 2014;9 (12):e114519 [PubMed]
Besseling J, Kindt I, Hof M, Kastelein JJP, Hutten BA, Hovingh GK, Severe heterozygous familial hypercholesterolemia and risk for cardiovascular disease: a study of a cohort of 14,000 mutation carriers. ATHEROSCLEROSIS 2014;233 (1):219-223 [PubMed]
Bochem AE, van Capelleveen JC, Dallinga-Thie GM, Schimmel AWM, Motazacker MM, Tietjen I, Singaraja RR, Hayden MR, Kastelein JJP, Stroes ESG, Hovingh GK, Two novel mutations in apolipoprotein C3 underlie atheroprotective lipid profiles in families. CLIN GENET 2014;85 (5):433-440 [PubMed]
Boekholdt SM, Hovingh GK, Mora S, Arsenault BJ, Amarenco P, Pedersen TR, LaRosa JC, Waters DD, Demicco DA, Simes RJ, Keech AC, Colquhoun D, Hitman GA, Betteridge DJ, Clearfield MB, Downs JR, Colhoun HM, Gotto AM Jr, Ridker PM, Grundy SM, Kastelein JJP, Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials. J AM COLL CARDIOL 2014;64 (5):485-494 [PubMed]
Braamskamp MJAM, Hutten BA, Wiegman A, Kastelein JJP, Management of hypercholesterolemia in children. PEDIATR DRUGS 2014;16 (2):105-114 [PubMed]
Braamskamp MJAM, Roelants RJ, Hutten BA, Kastelein JJP, The role of rosuvastatin in the treatment of pediatric homozygous familial hypercholesterolemia. EXPERT OPIN ORPHAN D 2014;2 (12):1325-1330
Flaim JD, Grundy JS, Baker BF, McGowan MP, Kastelein JJP, Changes in mipomersen dosing regimen provide similar exposure with improved tolerability in randomized placebo-controlled study of healthy volunteers. J AM HEART ASSOC 2014;3 (2):e000560 [PubMed]
Ford J, Lawson M, Fowler D, Maruyama N, Mito S, Tomiyasu K, Kinoshita S, Suzuki C, Kawaguchi A, Round P, Boyce M, Warrington S, Weber W, van Deventer S, Kastelein JJP, Tolerability, pharmacokinetics and pharmacodynamics of TA-8995, a selective cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects. BRIT J CLIN PHARMACO 2014;78 (3):498-508 [PubMed]
Fouchier SW, Dallinga-Thie GM, Meijers JCM, Zelcer N, Kastelein JJP, Defesche JC, Hovingh GK, Mutations in STAP1 are associated with autosomal dominant hypercholesterolemia. CIRC RES 2014;115 (6):552-555 [PubMed]
Friedrich S, Kastelein JJP, James D, Waterhouse T, Nissen SE, Nicholls SJ, Krueger KA, The pharmacokinetics and pharmacokinetic/pharmacodynamic relationships of evacetrapib administered as monotherapy or in combination with statins. CPT PHARMACOMETRICS SYST PHARMACOL 2014;3:e94 [PubMed]
Kastelein JJP, Decade in review--dyslipidaemia: Resurgence of targets and compounds to treat dyslipidaemia. NAT REV CARDIOL 2014;11 (11):629-631 [PubMed]
Kastelein JJP, Dyslipidaemia in perspective. LANCET 2014;384 (9943):566-568 [PubMed]
Kastelein JJP, Maki KC, Susekov A, Ezhov M, Nordestgaard BG, Machielse BN, Kling D, Davidson MH, Omega-3 free fatty acids for the treatment of severe hypertriglyceridemia: the EpanoVa fOr Lowering Very high triglyceridEs (EVOLVE) trial. J CLIN LIPIDOL 2014;8 (1):94-106 [PubMed]
Kastelein JJP, Robinson JG, Farnier M, Krempf M, Langslet G, Lorenzato C, Gipe DA, Baccara-Dinet MT, Efficacy and safety of alirocumab in patients with heterozygous familial hypercholesterolemia not adequately controlled with current lipid-lowering therapy: design and rationale of the ODYSSEY FH studies. CARDIOVASC DRUG THER 2014;28 (3):281-289 [PubMed]
Koopal C, Visseren FLJ, Kastelein JJP, Westerink J, Premature atherosclerosis, extremely low HDL-cholesterol and concurrent defects in APOA1 and ABCA1 genes: a family case report. INT J CARDIOL 2014;177 (1):e19-e21 [PubMed]
Kusters DM, Avis HJ, de Groot E, Wijburg FA, Kastelein JJP, Wiegman A, Hutten BA, Ten-year follow-up after initiation of statin therapy in children with familial hypercholesterolemia. JAMA-J AM MED ASSOC 2014;312 (10):1055-1057 [PubMed]
Kusters DM, Wiegman A, Kastelein JJP, Hutten BA, Carotid Intima-Media Thickness in Children With Familial Hypercholesterolemia. CIRC RES 2014;114 (2):307-310 [PubMed]
Maiwald S, Sivapalaratnam S, Motazacker MM, van Capelleveen JC, Bot I, de Jager SC, van Eck M, Jolley J, Kuiper J, Stephens J, Albers CA, Vosmeer CR, Kruize H, Geerke DP, van der Wal AC, van der Loos CM, Kastelein JJP, Trip MD, Ouwehand WH, Dallinga-Thie GM, Hovingh GK, Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis. PLOS ONE 2014;9 (5):e98289 [PubMed]
Mooij HL, Cabrales P, Bernelot Moens SJ, Xu D, Udayappan SD, Tsai AG, van der Sande MAJ, de Groot E, Intaglietta M, Kastelein JJP, Dallinga-Thie GM, Esko JD, Stroes ES, Nieuwdorp M, Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function. J AM HEART ASSOC 2014;3 (6):e001274 [PubMed]
Nicholls SJ, Kastelein JJP, Schwartz GG, Bash D, Rosenson RS, Cavender MA, Brennan DM, Koenig W, Jukema JW, Nambi V, Wright RS, Menon V, Lincoff AM, Nissen SE [Contributors: Hennekens C, Brown WV, DeMets D, Pfeffer M, Roleau J, Abraham J, Gebel J, Huff C, Katzan I, Shishehbor M, Rassi A, Uchino K, Vest A, Zishiri E, Heckman MJ, Balog C, Dart A, Amerena J, Prasad C, Farshid A, Gunalingam B, Thompson P, Collins N, Arstall M, van Gaal W, Aroney C, Mahar L, Youssef G, Horowitz J, Anand D, Rodes-Cabau J, Polasek P, Lai C, Huynh T, Hubacek J, Kokis A, Paradis JM, Mukherjee A, Senaratne M, Constance C, Gosselin G, Lavi S, Parker J, Zadra R, Abramson B, Della-Siega A, Spinar J, Pudil R, Motovska Z, Maly M, Hutyra M, Pleva L, Mayer O, Semenka J, Klimovic T, Horak D, Cervinka P, Klimsa Z, Hulinsky V, Reichert P, Monhart Z, Rotterova H, Kobulia B, Shaburishvili T, Mamatsashvili M, Chapidze G, Chumburidze V, Megreladze I, Khintibidze I, Leithäuser B, Voehringer HF, Wachter R, Nogai K, Lapp H, Haltern G, Gielen S, Dorsel T, Möllmann H, Stellbrink C, Hengstenberg C, Dengler T, Heuer H, Kreuzer J, Leschke M, Mudra H, Werner N, Braun-Dullaeus R, Rosenberg M, Frey N, Koenig W, Strasser R, Genth-Zotz S, Kiss R, Nagy A, Kovacs Z, Csapo K, Edes I, Sereg M, Vertes A, Ronaszeki A, Kancz S, Benczur B, Polgar P, Muller G, Simonyi G, Dezsi C, Merkely B, Dinnyes J, Lupkovics G, Kahali D, Banker D, Trivedi S, Rajput R, Premchand R, Dani S, Vadaganelli P, Gupta S, Chandra S, Fulwani M, Chawla K, Parikh K, Prati F, Speciale G, Valgimigli M, Suriano P, Berni A, Sangiorgi G, Fineschi M, Merenda R, Marenzi G, Berti S, Corrada E, Cuccia C, Testa R, Moretti L, Mennuni M, Biasucci LM, Lioy E, Auguadro C, Magagnini E, Fedele F, Piscione F, Azar R, Trip MD, Liem A, den Hartoog M, Lenderink T, van de Wetering MLJM, Lok D, Oei F, Tans JG, Ilmer B, Keijzers M, Monraats P, Kedhi E, Breedveld RW, Herrman JPR, van Wijk LM, Ronner E, Nierop P, Bosschaert M, Hermans W, Doevendans P, Troquay R, van der Heijden R, Veen G, Bokern MJJA, Bronzwaer PNA, Kie SH, den Hartog F, Elliott J, Wilkins G, Hart H, Devlin G, Harding S, Ponikowski P, Madej A, Kochmanski M, Witkowski A, Pluta W, Bronisz M, Kornacewicz-Jach Z, Wysokinski A, Ujda M, Drozdz J, Derlaga B, Gessek J, Dabrowski M, Miekus P, Kozlowski A, Gniot J, Musial W, Dobrzycki S, Rynkiewicz A, Psuja P, Rekosz J, Drzewiecki A, Kuznetsov V, Gordeev I, Goloshchekin B, Markov V, Barbarich V, Belenky D, Mikhin V, Volkova E, Timofeev A, Ermoshkina L, Barbarash O, Klein G, Libis R, Vishnevsky A, Linev K, Khaisheva L, Ruda M, Dovgalevskiy Y, Shvarts Y, Zateyshchikov D, Kostenko V, Shalnev V, Simanenkov V, Arkhipov M, Ovcharenko E, Guseva G, Akhunova S, Ortiz AIF, Navarro MJ, Romero AJF, Goya IL, Peñaranda AS, Cendon AA, Rubio AM, Zubiri JJB, Soriano FR, Sanz RR, Genís AB, Lago VN, Fernández JD, Romo AI, Franco SN, Martin IH, Montero JS, Martin MdM, González MJG, Antolin JMS, Areses ELdS, Miranda JM, Alonso-Pulpón L, Esquivias GB, Jarne EF, Cortés JMG, Pérez MB, Gormaz CL, Alegret JM, Nava JSH, Ingelmo JMG, Urbano RH, Sanmartín M, Katerenchuk O, Vakaliuk I, Karpenko O, Prokhorov O, Koval O, Faynyk A, Kopytsya M, Karpenko Y, Kraiz I, Feskov O, Rudenko L, Kozhukhov S, Goloborodko B, Rivera E, Broadwater S, Crowley S, Vijay N, Goswami R, Ferrier LN, Blanchard A, McCullum K, Chernick R, Bertolet B, Battaglia J, Richardson J, Lochridge S, Lieberman S, Amkieh A, Cavender JB, Denning S, Treasure C, Kmetzo J, Stillabower M, Brilakis E, Schwartz G, Acheatel R, Kukuy E, Ashchi M, Skelding K, Martin L, Gillespie E, French W, Pollock S, Polk D, Black R, Drenning D, Anderson J, Sanz M, Korban E, Wiley M, Rezkalla S, Minisi A, Shah A, Silverman P, Amlani M, Eaton G, Brown A, Jay D, Loussararian A, Lamas G, Lauer M, Williams J, Asfour A, Runquist L, Robertson R, Blonder R, Davies C, Downes T, Chronos N, Marso S, Haldis T, Eich D, Ahmed M, East C, MacDonald L, Seigel P, White M, Camp A, Kleiman N, Burtt D, Strain J, Go B, Henry P, Sultan P, Delafontaine P, Kashou H, Lambert C, Movahed MR, Saucedo J, Thadani U, Chandrashekhar Y, Lu D, Chandna H, Mann J, Ramaswamy G, Browne K, Janik M, Cannon K, Tolerico P]] , Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial. JAMA-J AM MED ASSOC 2014;311 (3):252-262 [PubMed]
Niesor EJ, Kallend D, Bentley D, Kastelein JJP, Kees Hovingh G, Stroes ESG, Treatment of low HDL-C subjects with the CETP modulator dalcetrapib increases plasma campesterol only in those without ABCA1 and/or ApoA1 mutations. LIPIDS 2014;49 (12):1245-1249 [PubMed]
Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K, Arsenault BJ, Donnelly LA, Wiggins KL, Avery CL, Griffin P, Feng Q, Taylor KD, Li G, Evans DS, Smith AV, de Keyser CE, Johnson AD, de Craen AJM, Stott DJ, Buckley BM, Ford I, Westendorp RGJ, Slagboom PE, Sattar N, Munroe PB, Sever P, Poulter N, Stanton A, Shields DC, O'Brien E, Shaw-Hawkins S, Chen YDI, Nickerson DA, Smith JD, Dubé MP, Boekholdt SM, Hovingh GK, Kastelein JJP, McKeigue PM, Betteridge J, Neil A, Durrington PN, Doney A, Carr F, Morris A, McCarthy MI, Groop L, Ahlqvist E, Bis JC, Rice K, Smith NL, Lumley T, Whitsel EA, Stürmer T, Boerwinkle E, Ngwa JS, O'Donnell CJ, Vasan RS, Wei WQ, Wilke RA, Liu CT, Sun F, Guo X, Heckbert SR, Post W, Sotoodehnia N, Arnold AM, Stafford JM, Ding J, Herrington DM, Kritchevsky SB, Eiriksdottir G, Launer LJ, Harris TB, Chu AY, Giulianini F, Macfadyen JG, Barratt BJ, Nyberg F, Stricker BH, Uitterlinden AG, Hofman A, Rivadeneira F, Emilsson V, Franco OH, Ridker PM, Gudnason V, Liu Y, Denny JC, Ballantyne CM, Rotter JI, Adrienne Cupples L, Psaty BM, Palmer CNA, Tardif JC, Colhoun HM, Hitman G, Krauss RM, Wouter Jukema J, Caulfield MJ [Contributors: Donnelly P, Barroso I, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Deloukas P, Duncanson A, Jankowski J, Markus HS, Mathew CG, Palmer CNA, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Wood NW, Spencer CCA, Band G, Bellenguez C, Freeman C, Hellenthal G, Giannoulatou E, Pirinen M, Pearson R, Strange A, Su Z, Vukcevic D, Langford C, Hunt SE, Edkins S, Gwilliam R, Blackburn H, Bumpstead SJ, Dronov S, Gillman M, Gray E, Hammond N, Jayakumar A, McCann OT, Liddle J, Potter SC, Ravindrarajah R, Ricketts M, Waller M, Weston P, Widaa S, Whittaker P, McCarthy MI]] , Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. NAT COMMUN 2014;5:5068 [PubMed]
Rader DJ, Kastelein JJP, Lomitapide and Mipomersen Two First-in-Class Drugs for Reducing Low-Density Lipoprotein Cholesterol in Patients With Homozygous Familial Hypercholesterolemia. CIRCULATION 2014;129 (9):1022-1032 [PubMed]
Ray KK, Kastelein JJP, Boekholdt SM, Nicholls SJ, Khaw KT, Ballantyne CM, Catapano AL, Reiner Ž, Lüscher TF, The ACC/AHA 2013 guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk in adults: the good the bad and the uncertain: a comparison with ESC/EAS guidelines for the management of dyslipidaemias 2011. EUR HEART J 2014;35 (15):960-968 [PubMed]
Roth EM, Taskinen MR, Ginsberg HN, Kastelein JJP, Colhoun HM, Robinson JG, Merlet L, Pordy R, Baccara-Dinet MT, Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: results of a 24 week, double-blind, randomized Phase 3 trial. INT J CARDIOL 2014;176 (1):55-61 [PubMed]
Sattar NA, Ginsberg H, Ray K, Chapman MJ, Arca M, Averna M, Betteridge DJ, Bhatnagar D, Bilianou E, Carmena R, Ceška R, Corsini A, Erbel R, Flynn PD, Garcia-Moll X, Gumprecht J, Ishibashi S, Jambart S, Kastelein JJP, Maher V, da Silva PM, Masana L, Odawara M, Pedersen TR, Rotella CM, Salti I, Teramoto T, Tokgozoglu L, Toth PP, Valensi P, Vergès B, The use of statins in people at risk of developing diabetes mellitus: evidence and guidance for clinical practice. ATHEROSCLEROSIS SUPP 2014;15 (1):1-15 [PubMed]
Singaraja RR, Tietjen I, Hovingh GK, Franchini PL, Radomski C, Wong K, vanHeek M, Stylianou IM, Lin L, Wang L, Mitnaul L, Hubbard B, Winther M, Mattice M, Legendre A, Sherrington R, Kastelein JJ, Akinsanya K, Plump A, Hayden MR, Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans. J LIPID RES 2014;55 (8):1693-1701 [PubMed]
Sjouke B, Langslet G, Ceska R, Nicholls SJ, Nissen SE, Öhlander M, Ladenson PW, Olsson AG, Hovingh GK, Kastelein JJP, Eprotirome in patients with familial hypercholesterolaemia (the AKKA trial): a randomised, double-blind, placebo-controlled phase 3 study. LANCET DIABETES ENDO 2014;2 (6):455-463 [PubMed]
Tardif JC, Ballantyne CM, Barter P, Dasseux JL, Fayad ZA, Guertin MC, Kastelein JJP, Keyserling C, Klepp H, Koenig W, L'allier PL, Lespérance J, Lüscher TF, Paolini JF, Tawakol A, Waters DD [Contributors: Pfeffer M, Brown V, Rouleau J, Watkins P, Wei LJ, Gosselin G, Chayer C, Lanthier S, Pelletier GB, Racine N, Agarwal H, Brilakis E, Cannon L, Carrié D, Corbelli J, Coste P, de Winter R, Diaz A, Eisenberg S, Ennis B, Fajadet J, Fam N, Fortuin D, Gessler C, Grines C, Guerra D, Gum H, Haldis T, Heestermans T, Herrman JP, Huynh T, Kedhi E, Koren M, Kouz S, Krolick M, Kumkumian G, Lavi S, Li RJ, Masud ARZ, McAlhany C, McGrew FA, O'Shaughnessy C, Oude Ophuis AJM, Parr K, Penny W, Pesant Y, Robinson S, Rodes-Cabau J, Roy A, Schulman S, Spence F, Stouffer G, Stys T, Sussex B, Tahirkheli N, Tardif JC, Grégoire J, ten Berg J, van Boven AJ, von Birgelen C, Weinstein D]] , Effects of the high-density lipoprotein mimetic agent CER-001 on coronary atherosclerosis in patients with acute coronary syndromes: a randomized trial. EUR HEART J 2014;35 (46):3277-3286 [PubMed]
Teeuw WJ, Slot DE, Susanto H, Gerdes VEA, Abbas F, D'Aiuto F, Kastelein JJP, Loos BG, Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta-analysis. J CLIN PERIODONTOL 2014;41 (1):70-79 [PubMed]
Tragante V, Barnes MR, Ganesh SK, Lanktree MB, Guo W, Franceschini N, Smith EN, Johnson T, Holmes MV, Padmanabhan S, Karczewski KJ, Almoguera B, Barnard J, Baumert J, Chang YPC, Elbers CC, Farrall M, Fischer ME, Gaunt TR, Gho JMIH, Gieger C, Goel A, Gong Y, Isaacs A, Kleber ME, Mateo Leach I, McDonough CW, Meijs MFL, Melander O, Nelson CP, Nolte IM, Pankratz N, Price TS, Shaffer J, Shah S, Tomaszewski M, van der Most PJ, van Iperen EPA, Vonk JM, Witkowska K, Wong COL, Zhang L, Beitelshees AL, Berenson GS, Bhatt DL, Brown M, Burt A, Cooper-DeHoff RM, Connell JM, Cruickshanks KJ, Curtis SP, Davey-Smith G, Delles C, Gansevoort RT, Guo X, Haiqing S, Hastie CE, Hofker MH, Hovingh GK, Kim DS, Kirkland SA, Klein BE, Klein R, Li YR, Maiwald S, Newton-Cheh C, O'Brien ET, Onland-Moret NC, Palmas W, Parsa A, Penninx BW, Pettinger M, Vasan RS, Ranchalis JE, M Ridker P, Rose LM, Sever P, Shimbo D, Steele L, Stolk RP, Thorand B, Trip MD, van Duijn CM, Verschuren WM, Wijmenga C, Wyatt S, Young JH, Zwinderman AH, Bezzina CR, Boerwinkle E, Casas JP, Caulfield MJ, Chakravarti A, Chasman DI, Davidson KW, Doevendans PA, Dominiczak AF, FitzGerald GA, Gums JG, Fornage M, Hakonarson H, Halder I, Hillege HL, Illig T, Jarvik GP, Johnson JA, Kastelein JJP, Koenig W, Kumari M, März W, Murray SS, O'Connell JR, Oldehinkel AJ, Pankow JS, Rader DJ, Redline S, Reilly MP, Schadt EE, Kottke-Marchant K, Snieder H, Snyder M, Stanton AV, Tobin MD, Uitterlinden AG, van der Harst P, van der Schouw YT, Samani NJ, Watkins H, Johnson AD, Reiner AP, Zhu X, de Bakker PIW, Levy D, Asselbergs FW, Munroe PB, Keating BJ, Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. AM J HUM GENET 2014;94 (3):349-360 [PubMed]
van Capelleveen JC, Brewer HB, Kastelein JJP, Hovingh GK, Novel Therapies Focused on the High-Density Lipoprotein Particle. CIRC RES 2014;114 (1):193-204 [PubMed]
van Iperen EPA, Sivapalaratnam S, Boekholdt SM, Hovingh GK, Maiwald S, Tanck MW, Soranzo N, Stephens JC, Sambrook JG, Levi M, Ouwehand WH, Kastelein JJ, Trip MD, Zwinderman AH, Common genetic variants do not associate with CAD in familial hypercholesterolemia. EUR J HUM GENET 2014;22 (6):809-813 [PubMed]
van Wijk DF, Sjouke B, Figueroa A, Emami H, van der Valk FM, MacNabb MH, Hemphill LC, Schulte DM, Koopman MG, Lobatto ME, Verberne HJ, Fayad ZA, Kastelein JJP, Mulder WJM, Hovingh GK, Tawakol A, Stroes ESG, Nonpharmacological lipoprotein apheresis reduces arterial inflammation in familial hypercholesterolemia. J AM COLL CARDIOL 2014;64 (14):1418-1426 [PubMed]
van Wijk DF, Strang AC, Duivenvoorden R, Enklaar DJF, van der Geest RJ, Kastelein JJP, de Groot E, Stroes ESG, Nederveen AJ, Increasing spatial resolution of 3T MRI scanning improves reproducibility of carotid arterial wall dimension measurements. MAGN RESON MATER PHY 2014;27 (3):219-226 [PubMed]
Watts GF, Gidding S, Wierzbicki AS, Toth PP, Alonso R, Brown WV, Bruckert E, Defesche J, Lin KK, Livingston M, Mata P, Parhofer KG, Raal FJ, Santos RD, Sijbrands EJG, Simpson WG, Sullivan DR, Susekov AV, Tomlinson B, Wiegman A, Yamashita S, Kastelein JJP, Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation. INT J CARDIOL 2014;171 (3):309-325 [PubMed]
Watts GF, Gidding S, Wierzbicki AS, Toth PP, Alonso R, Brown WV, Bruckert E, Defesche J, Lin KK, Livingston M, Mata P, Parhofer KG, Raal FJ, Santos RD, Sijbrands EJG, Simpson WG, Sullivan DR, Susekov AV, Tomlinson B, Wiegman A, Yamashita S, Kastelein JJP, Integrated Guidance on the Care of Familial Hypercholesterolaemia from the International FH Foundation: Executive Summary. J ATHEROSCLER THROMB 2014;21 (4):368-374 [PubMed]
Watts GF, Gidding S, Wierzbicki AS, Toth PP, Alonso R, Brown WV, Bruckert E, Defesche J, Lin KK, Livingston M, Mata P, Parhofer KG, Raal FJ, Santos RD, Sijbrands EJG, Simpson WG, Sullivan DR, Susekov AV, Tomlinson B, Wiegman A, Yamashita S, Kastelein JJP, Integrated guidance on the care of familial hypercholesterolemia from the International FH Foundation. J CLIN LIPIDOL 2014;8 (2):148-172 [PubMed]
Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan Ja, Kutalik Z, Amin N, Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y, Fall T, Fehrmann R, Ferreira T, Jackson AU, Karjalainen J, Lo KS, Locke AE, Mägi R, Mihailov E, Porcu E, Randall JC, Scherag A, Vinkhuyzen AAE, Westra HJ, Winkler TW, Workalemahu T, Zhao JH, Absher D, Albrecht E, Anderson D, Baron J, Beekman M, Demirkan A, Ehret GB, Feenstra B, Feitosa MF, Fischer K, Fraser RM, Goel A, Gong J, Justice AE, Kanoni S, Kleber ME, Kristiansson K, Lim U, Lotay V, Lui JC, Mangino M, Mateo Leach I, Medina-Gomez C, Nalls MA, Nyholt DR, Palmer CD, Pasko D, Pechlivanis S, Prokopenko I, Ried JS, Ripke S, Shungin D, Stancáková A, Strawbridge RJ, Sung YJ, Tanaka T, Teumer A, Trompet S, van der Laan SW, van Setten J, van Vliet-Ostaptchouk JV, Wang Z, Yengo L, Zhang W, Afzal U, Arnlöv J, Arscott GM, Bandinelli S, Barrett A, Bellis C, Bennett AJ, Berne C, Blüher M, Bolton JL, Böttcher Y, Boyd HA, Bruinenberg M, Buckley BM, Buyske S, Caspersen IH, Chines PS, Clarke R, Claudi-Boehm S, Cooper M, Daw EW, de Jong PA, Deelen J, Delgado G, Denny JC, Dhonukshe-Rutten R, Dimitriou M, Doney ASF, Dörr M, Eklund N, Eury E, Folkersen L, Garcia ME, Geller F, Giedraitis V, Go AS, Grallert H, Grammer TB, Gräßler J, Grönberg H, de Groot LCPGM, Groves CJ, Haessler J, Hall P, Haller T, Hallmans G, Hannemann A, Hartman CA, Hassinen M, Hayward C, Heard-Costa NL, Helmer Q, Hemani G, Henders AK, Hillege HL, Hlatky MA, Hoffmann W, Hoffmann P, Holmen O, Houwing-Duistermaat JJ, Illig T, Isaacs A, James AL, Jeff J, Johansen B, Johansson Å, Jolley J, Juliusdottir T, Junttila J, Kho AN, Kinnunen L, Klopp N, Kocher T, Kratzer W, Lichtner P, Lind L, Lindström J, Lobbens S, Lorentzon M, Lu Y, Lyssenko V, Magnusson PKE, Mahajan A, Maillard M, McArdle WL, McKenzie CA, McLachlan S, McLaren PJ, Menni C, Merger S, Milani L, Moayyeri A, Monda KL, Morken MA, Müller G, Müller-Nurasyid M, Musk AW, Narisu N, Nauck M, Nolte IM, Nöthen MM, Oozageer L, Pilz S, Rayner NW, Renstrom F, Robertson NR, Rose LM, Roussel R, Sanna S, Scharnagl H, Scholtens S, Schumacher FR, Schunkert H, Scott RA, Sehmi J, Seufferlein T, Shi J, Silventoinen K, Smit JH, Smith AV, Smolonska J, Stanton AV, Stirrups K, Stott DJ, Stringham HM, Sundström J, Swertz MA, Syvänen AC, Tayo BO, Thorleifsson G, Tyrer JP, van Dijk S, van Schoor NM, van der Velde N, van Heemst D, van Oort FVA, Vermeulen SH, Verweij N, Vonk JM, Waite LL, Waldenberger M, Wennauer R, Wilkens LR, Willenborg C, Wilsgaard T, Wojczynski MK, Wong A, Wright AF, Zhang Q, Arveiler D, Bakker SJL, Beilby J, Bergman RN, Bergmann S, Biffar R, Blangero J, Boomsma DI, Bornstein SR, Bovet P, Brambilla P, Brown MJ, Campbell H, Caulfield MJ, Chakravarti A, Collins R, Collins FS, Crawford DC, Cupples LA, Danesh J, de Faire U, den Ruijter HM, Erbel R, Erdmann J, Eriksson JG, Farrall M, Ferrannini E, Ferrières J, Ford I, Forouhi NG, Forrester T, Gansevoort RT, Gejman PV, Gieger C, Golay A, Gottesman O, Gudnason V, Gyllensten U, Haas DW, Hall AS, Harris TB, Hattersley AT, Heath AC, Hengstenberg C, Hicks AA, Hindorff LA, Hingorani AD, Hofman A, Hovingh GK, Humphries SE, Hunt SC, Hypponen E, Jacobs KB, Jarvelin MR, Jousilahti P, Jula AM, Kaprio J, Kastelein JJP, Kayser M, Kee F, Keinanen-Kiukaanniemi SM, Kiemeney LA, Kooner JS, Kooperberg C, Koskinen S, Kovacs P, Kraja AT, Kumari M, Kuusisto J, Lakka TA, Langenberg C, Le Marchand L, Lehtimäki T, Lupoli S, Madden PAF, Männistö S, Manunta P, Marette A, Matise TC, McKnight B, Meitinger T, Moll FL, Montgomery GW, Morris AD, Morris AP, Murray JC, Nelis M, Ohlsson C, Oldehinkel AJ, Ong KK, Ouwehand WH, Pasterkamp G, Peters A, Pramstaller PP, Price JF, Qi L, Raitakari OT, Rankinen T, Rao DC, Rice TK, Ritchie M, Rudan I, Salomaa V, Samani NJ, Saramies J, Sarzynski MA, Schwarz PEH, Sebert S, Sever P, Shuldiner AR, Sinisalo J, Steinthorsdottir V, Stolk RP, Tardif JC, Tönjes A, Tremblay A, Tremoli E, Virtamo J, Vohl MC, Amouyel P, Asselbergs FW, Assimes TL, Bochud M, Boehm BO, Boerwinkle E, Bottinger EP, Bouchard C, Cauchi S, Chambers JC, Chanock SJ, Cooper RS, de Bakker PIW, Dedoussis G, Ferrucci L, Franks PW, Froguel P, Groop LC, Haiman CA, Hamsten A, Hayes MG, Hui J, Hunter DJ, Hveem K, Jukema JW, Kaplan RC, Kivimaki M, Kuh D, Laakso M, Liu Y, Martin NG, März W, Melbye M, Moebus S, Munroe PB, Njølstad I, Oostra BA, Palmer CNA, Pedersen NL, Perola M, Pérusse L, Peters U, Powell JE, Power C, Quertermous T, Rauramaa R, Reinmaa E, Ridker PM, Rivadeneira F, Rotter JI, Saaristo TE, Saleheen D, Schlessinger D, Slagboom PE, Snieder H, Spector TD, Strauch K, Stumvoll M, Tuomilehto J, Uusitupa M, van der Harst P, Völzke H, Walker M, Wareham NJ, Watkins H, Wichmann HE, Wilson JF, Zanen P, Deloukas P, Heid IM, Lindgren CM, Mohlke KL, Speliotes EK, Thorsteinsdottir U, Barroso I, Fox CS, North KE, Strachan DP, Beckmann JS, Berndt SI, Boehnke M, Borecki IB, McCarthy MI, Metspalu A, Stefansson K, Uitterlinden AG, van Duijn CM, Franke L, Willer CJ, Price AL, Lettre G, Loos RJF, Weedon MN, Ingelsson E, O'Connell JR, Abecasis GR, Chasman DI, Goddard ME, Visscher PM, Hirschhorn JN, Frayling TM [Contributors: McCarty CA, Starren J, Peissig P, Berg R, Rasmussen L, Linneman J, Miller A, Choudary V, Chen L, Waudby C, Kitchner T, Reeser J, Fost N, Ritchie M, Wilke RA, Chisholm RL, Avila PC, Greenland P, Hayes MG, Kho A, Kibbe WA, Lemke AA, Lowe WL, Smith ME, Wolf WA, Pacheco JA, Thompson WK, Humowiecki J, Law M, Chute C, Kullo I, Koenig B, de Andrade M, Bielinski S, Pathak J, Savova G, Wu J, Henriksen J, Ding K, Hart L, Palbicki J, Larson EB, Newton K, Ludman E, Spangler L, Hart G, Carrell D, Jarvik G, Crane P, Burke W, Fullerton SM, Trinidad SB, Carlson C, Hutchinson F, McDavid A, Roden DM, Clayton E, Haines JL, Masys DR, Churchill LR, Cornfield D, Crawford D, Darbar D, Denny JC, Malin BA, Ritchie MD, Schildcrout JS, Xu H, Ramirez AH, Basford M, Pulley J, Alizadeh BZ, de Boer RA, Boezen HM, Bruinenberg M, Franke L, van der Harst P, Hillege HL, van der Klauw MM, Navis G, Ormel J, Postma DS, Rosmalen JGM, Slaets JP, Snieder H, Stolk RP, Wolffenbuttel BHR, Wijmenga C, Kathiresan S, Voight BF, Purcell S, Musunuru K, Ardissino D, Mannucci PM, Anand S, Engert JC, Samani NJ, Schunkert H, Erdmann J, Reilly MP, Rader DJ, Morgan T, Spertus JA, Stoll M, Girelli D, McKeown PP, Patterson CC, Siscovick DS, O'Donnell CJ, Elosua R, Peltonen L, Salomaa V, Schwartz SM, Melander O, Altshuler D, Merlini PA, Berzuini C, Bernardinelli L, Peyvandi F, Tubaro M, Celli P, Ferrario M, Fetiveau R, Marziliano N, Casari G, Galli M, Ribichini F, Rossi M, Bernardi F, Zonzin P, Piazza A, Yee J, Friedlander Y, Marrugat J, Lucas G, Subirana I, Sala J, Ramos R, Meigs JB, Williams G, Nathan DM, MacRae CA, Havulinna AS, Berglund G, Hirschhorn JN, Asselta R, Duga S, Spreafico M, Daly MJ, Nemesh J, Korn JM, McCarroll SA, Surti A, Guiducci C, Gianniny L, Mirel D, Parkin M, Burtt N, Gabriel SB, Thompson JR, Braund PS, Wright BJ, Balmforth AJ, Ball SG, Hall AS, Schunkert IH, Linsel-Nitschke P, Lieb W, Ziegler A, König IR, Hengstenberg C, Fischer M, Stark K, Grosshennig A, Preuss M, Wichmann HE, Schreiber S, Ouwehand W, Deloukas P, Scholz M, Cambien F, Goodall A, Li M, Chen Z, Wilensky R, Matthai W, Qasim A, Hakonarson HH, Devaney J, Burnett MS, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Knouff CW, Waterworth DM, Walker MC, Mooser V, Epstein SE, Scheffold T, Berger K, Huge A, Martinelli N, Olivieri O, Corrocher R, Hólm H, Thorleifsson G, Thorsteinsdottir U, Stefansson K, Do R, Xie C, Siscovick D, Matise T, Buyske S, Higashio J, Williams R, Nato A, Ambite JL, Deelman E, Manolio T, Hindorff L, North KE, Heiss G, Taylor K, Franceschini N, Avery C, Graff M, Lin D, Quibrera M, Cochran B, Kao L, Umans J, Cole S, MacCluer J, Person S, Pankow J, Gross M, Boerwinkle E, Fornage M, Durda P, Jenny N, Patsy B, Arnold A, Buzkova P, Haines J, Murdock D, Glenn K, Brown-Gentry K, Thornton-Wells T, Dumitrescu L, Jeff J, Bush WS, Mitchell SL, Goodloe R, Wilson S, Boston J, Malinowski J, Restrepo N, Oetjens M, Fowke J, Zheng W, Spencer K, Pendergrass S, Le Marchand L, Wilkens L, Park L, Tiirikainen M, Kolonel L, Lim U, Cheng I, Wang H, Shohet R, Haiman C, Stram D, Henderson B, Monroe K, Schumacher F, Kooperberg C, Peters U, Anderson G, Prentice R, LaCroix A, Wu C, Carty C, Gong J, Rosse S, Young A, Haessler J, Kocarnik J, Lin Y, Jackson R, Duggan D, Kuller L]] , Defining the role of common variation in the genomic and biological architecture of adult human height. 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Arsenault BJ, Barter P, Demicco DA, Bao W, Preston GM, LaRosa JC, Grundy SM, Deedwania P, Greten H, Wenger NK, Shepherd J, Waters DD, Kastelein JJP, Prediction of cardiovascular events in statin-treated patients by lipid and non-lipid biomarkers (Retraction of vol 57, pg 63, 2011). J AM COLL CARDIOL 2013;61 (16):1750
Avis HJ. Childhood initiated statin therapy in familial hypercholesterolemia. s.l.: s.n.; 2013. 256p. ISBN 97890902777240 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP, Wijburg FA; copromotor(s): Hutten BA, Vissers MN, Wiegman A)
Besseling J, van Capelleveen J, Kastelein JJP, Hovingh GK, LDL cholesterol goals in high-risk patients: how low do we go and how do we get there?. DRUGS 2013;73 (4):293-301 [PubMed]
Bochem AE, van Wijk DF, Holleboom AG, Duivenvoorden R, Motazacker MM, Dallinga-Thie GM, de Groot E, Kastelein JJP, Nederveen AJ, Hovingh GK, Stroes ESG, ABCA1 mutation carriers with low high-density lipoprotein cholesterol are characterized by a larger atherosclerotic burden. EUR HEART J 2013;34 (4):286-291 [PubMed]
Boekholdt SM, Arsenault BJ, Hovingh GK, Mora S, Pedersen TR, LaRosa JC, Welch KMA, Amarenco P, Demicco DA, Tonkin AM, Sullivan DR, Kirby A, Colhoun HM, Hitman GA, Betteridge DJ, Durrington PN, Clearfield MB, Downs JR, Gotto AM Jr, Ridker PM, Kastelein JJP, Levels and changes of HDL cholesterol and apolipoprotein A-I in relation to risk of cardiovascular events among statin-treated patients: a meta-analysis. CIRCULATION 2013;128 (14):1504-1512 [PubMed]
Braamskamp MJAM, Tsimikas S, Wiegman A, Kastelein JJP, Hutten BA, Statin therapy and secretory phospholipase A₂ in children with heterozygous familial hypercholesterolemia. ATHEROSCLEROSIS 2013;229 (2):404-407 [PubMed]
Brinton EA, Ballantyne CM, Bays HE, Kastelein JJ, Braeckman RA, Soni PN, Effects of icosapent ethyl on lipid and inflammatory parameters in patients with diabetes mellitus-2, residual elevated triglycerides (200-500 mg/dL), and on statin therapy at LDL-C goal: the ANCHOR study. CARDIOVASC DIABETOL 2013;12 (1):100 [PubMed]
Charakida M, de Groot E, Loukogeorgakis SP, Khan T, Lüscher T, Kastelein JJ, Gasser T, Deanfield JE, Variability and reproducibility of flow-mediated dilatation in a multicentre clinical trial. EUR HEART J 2013;34 (45):3501-3507 [PubMed]
Dorresteijn JAN, Boekholdt SM, van der Graaf Y, Kastelein JJP, LaRosa JC, Pedersen TR, Demicco DA, Ridker PM, Cook NR, Visseren FLJ, High-dose statin therapy in patients with stable coronary artery disease: treating the right patients based on individualized prediction of treatment effect. CIRCULATION 2013;127 (25):2485-2493 [PubMed]
Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, den Hertog HM, Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K, Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkilä K, Hyppönen E, Isaacs A, Jackson AU, Johansson A, Johnson T, Kaakinen M, Kettunen J, Kleber ME, Li X, Luan Ja, Lyytikäinen LP, Magnusson PKE, Mangino M, Mihailov E, Montasser ME, Müller-Nurasyid M, Nolte IM, O'Connell JR, Palmer CD, Perola M, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, van den Herik EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher D, Asiki G, Barroso I, Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney ASF, Döring A, Elliott P, Epstein SE, Eyjolfsson GI, Gigante B, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hallmans G, Hartikainen AL, Hayward C, Hernandez D, Hicks AA, Holm H, Hung YJ, Illig T, Jones MR, Kaleebu P, Kastelein JJP, Khaw KT, Kim E, Klopp N, Komulainen P, Kumari M, Langenberg C, Lehtimäki T, Lin SY, Lindström J, Loos RJF, Mach F, McArdle WL, Meisinger C, Mitchell BD, Müller G, Nagaraja R, Narisu N, Nieminen TVM, Nsubuga RN, Olafsson I, Ong KK, Palotie A, Papamarkou T, Pomilla C, Pouta A, Rader DJ, Reilly MP, Ridker PM, Rivadeneira F, Rudan I, Ruokonen A, Samani N, Scharnagl H, Seeley J, Silander K, Stančáková A, Stirrups K, Swift AJ, Tiret L, Uitterlinden AG, van Pelt LJ, Vedantam S, Wainwright N, Wijmenga C, Wild SH, Willemsen G, Wilsgaard T, Wilson JF, Young EH, Zhao JH, Adair LS, Arveiler D, Assimes TL, Bandinelli S, Bennett F, Bochud M, Boehm BO, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier M, Campbell H, Chakravarti A, Chambers JC, Chen YDI, Collins FS, Cooper RS, Danesh J, Dedoussis G, de Faire U, Feranil AB, Ferrières J, Ferrucci L, Freimer NB, Gieger C, Groop LC, Gudnason V, Gyllensten U, Hamsten A, Harris TB, Hingorani A, Hirschhorn JN, Hofman A, Hovingh GK, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Iribarren C, Järvelin MR, Jula A, Kähönen M, Kaprio J, Kesäniemi A, Kivimaki M, Kooner JS, Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J, Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren CM, Martin NG, März W, McCarthy MI, McKenzie CA, Meneton P, Metspalu A, Moilanen L, Morris AD, Munroe PB, Njølstad I, Pedersen NL, Power C, Pramstaller PP, Price JF, Psaty BM, Quertermous T, Rauramaa R, Saleheen D, Salomaa V, Sanghera DK, Saramies J, Schwarz PEH, Sheu WHH, Shuldiner AR, Siegbahn A, Spector TD, Stefansson K, Strachan DP, Tayo BO, Tremoli E, Tuomilehto J, Uusitupa M, van Duijn CM, Vollenweider P, Wallentin L, Wareham NJ, Whitfield JB, Wolffenbuttel BHR, Altshuler D, Ordovas JM, Boerwinkle E, Palmer CNA, Thorsteinsdottir U, Chasman DI, Rotter JI, Franks PW, Ripatti S, Cupples LA, Sandhu MS, Rich SS, Boehnke M, Deloukas P, Mohlke KL, Ingelsson E, Abecasis GR, Daly MJ, Neale BM, Kathiresan S, Common variants associated with plasma triglycerides and risk for coronary artery disease. NAT GENET 2013;45 (11):1345-1352 [PubMed]
Duivenvoorden R. Innovative imaging techniques for improved characterization of atherosclerosis and the assessment of novel therapies. s.l.: s.n.; 2013. 301p. ISBN 97890902777226 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP, Stroes ESG; copromotor(s): Nederveen AJ, de Groot E, Mulder WJM)
Duivenvoorden R, van Wijk D, Klimas M, Kastelein JJP, Stroes ESG, Nederveen AJ, Detection of liquid phase cholesteryl ester in carotid atherosclerosis by 1H-MR spectroscopy in humans. JACC-CARDIOVASC IMAG 2013;6 (12):1277-1284 [PubMed]
Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA, Barnard J, Baumert J, Chang YPC, Elbers CC, Farrall M, Fischer ME, Franceschini N, Gaunt TR, Gho JMIH, Gieger C, Gong Y, Isaacs A, Kleber ME, Mateo Leach I, McDonough CW, Meijs MFL, Mellander O, Molony CM, Nolte IM, Padmanabhan S, Price TS, Rajagopalan R, Shaffer J, Shah S, Shen H, Soranzo N, van der Most PJ, van Iperen EPA, van Setten JA, Vonk JM, Zhang L, Beitelshees AL, Berenson GS, Bhatt DL, Boer JMA, Boerwinkle E, Burkley B, Burt A, Chakravarti A, Chen W, Cooper-DeHoff RM, Curtis SP, Dreisbach A, Duggan D, Ehret GB, Fabsitz RR, Fornage M, Fox E, Furlong CE, Gansevoort RT, Hofker MH, Hovingh GK, Kirkland SA, Kottke-Marchant K, Kutlar A, LaCroix AZ, Langaee TY, Li YR, Lin H, Liu K, Maiwald S, Malik R, Murugesan G, Newton-Cheh C, O'Connell JR, Onland-Moret NC, Ouwehand WH, Palmas W, Penninx BW, Pepine CJ, Pettinger M, Polak JF, Ramachandran VS, Ranchalis J, Redline S, Ridker PM, Rose LM, Scharnag H, Schork NJ, Shimbo D, Shuldiner AR, Srinivasan SR, Stolk RP, Taylor HA, Thorand B, Trip MD, van Duijn CM, Verschuren WM, Wijmenga C, Winkelmann BR, Wyatt S, Young JH, Boehm BO, Caulfield MJ, Chasman DI, Davidson KW, Doevendans PA, FitzGerald GA, Gums JG, Hakonarson H, Hillege HL, Illig T, Jarvik GP, Johnson JA, Kastelein JJP, Koenig W, März W, Mitchell BD, Murray SS, Oldehinkel AJ, Rader DJ, Reilly MP, Reiner AP, Schadt EE, Silverstein RL, Snieder H, Stanton AV, Uitterlinden AG, van der Harst P, van der Schouw YT, Samani NJ, Johnson AD, Munroe PB, de Bakker PIW, Zhu X, Levy D, Keating BJ, Asselbergs FW, Loci influencing blood pressure identified using a cardiovascular gene-centric array. HUM MOL GENET 2013;22 (8):1663-1678 [PubMed]
Guo Y, Lanktree MB, Taylor KC, Hakonarson H, Lange LA, Keating BJ [Contributors: Guo Y, Lanktree MB, Taylor KC, Fairfax BP, Elbers CC, Barnard J, Farrall M, Padmanabhan S, Baumert J, Castillo BA, Gaunt TR, Gong Y, Rajagopalan R, Romaine SPR, Kumari M, Rafelt S, Smith EN, Li YR, Sivapalaratnam S, van Iperen EPA, Speliotes EK, Toskala E, Zhang L, Ochs-Balcom HM, Bhangale TR, Chandrupatla HR, Drenos F, Gieger C, Gupta J, Johnson T, Kleber ME, Makino S, Mangino M, Meng Y, Nelson CP, Pankow JS, Pankratz N, Price TS, Shaffer J, Shen H, Tischfield S, Tomaszewski M, Atwood LD, Bailey KM, Balasubramanyam A, Baldwin CT, Basart H, Bauer F, Behr ER, Beitelshees AL, Berenson GS, Beresford SAA, Bezzina CR, Bhatt DL, Boer JMA, Braund PS, Burke GL, Burkley B, Carty C, Chen W, Clarke R, Cooper-DeHoff RM, Curtis SP, de Bakker PIW, de Jong JS, Delles C, Dominiczak AF, Duggan D, Feldman HI, Furlong CE, Gorski MM, Gums JG, Hardwick R, Hastie C, Heid IM, Huang GH, Huggins GS, Humphries SE, Kirkland SA, Kivimaki M, Klein R, Klein BE, Knowler WC, Kottke-Marchant K, LaCroix AZ, Langaee TY, Li M, Lyon HN, Maiwald S, Marshall JK, Mehta A, Meijs MFL, Melander O, Meyer N, Mitra N, Molony CM, Morrow DA, Murugesan G, Newhouse SJ, Nieto JF, Onland-Moret NC, Ouwehand WH, Palmen J, Pepine CJ, Ranchalis J, Rosas SE, Rosenthal EA, Scharnagl H, Schork NJ, Schreiner PJ, Shah T, Shashaty M, Shimbo D, Srinivasan SR, Thomas F, Tobin MD, Tsai MY, Verschuren WMM, Wagenknecht LE, Winkelmann BR, Young T, Yusuf S, Zafarmand MH, Zmuda JM, Zwinderman AH, Anand SS, Balmforth AJ, Boehm BO, Boerwinkle E, Burton PR, Cappola TP, Casas JP, Caulfield MJ, Christiani DC, Christie J, Cruickshanks KJ, Davey-Smith G, Davidson KW, Day IN, Doevendans PA, Dorn GW 2nd, FitzGerald GA, Hall AS, Hingorani AD, Hirschhorn JN, Hofker MH, Hovingh KG, Illig T, Jamshidi Y, Jarvik GP, Johnson JA, Kanetsky PA, Kastelein JJP, Koenig W, Lawlor DA, März W, McCaffery J, Mega JL, Mitchell BD, Murray SS, O'Connell JR, Patel SR, Peters A, Pettinger M, Rader DJ, Redline S, Reilly MP, Sabatine MS, Schadt EE, Shuldiner AR, Silverstein RL, Spector TD, Taylor HA, Thorand B, Trip MD, Watkins H, Wichmann HE, Fox CS, Grant SFA, Peter I, Talmud PJ, Munroe PB, Wilson JG, Knight JC, Samani NJ, Hegele RA, Asselbergs FW, Monda KL, van der Schouw YT, Demerath EW, Wijmenga C, Timpson NJ, Reiner AP, North KE, Papanicolaou GJ, Hakonarson H, Lange LA, Keating BJ]] , Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. HUM MOL GENET 2013;22 (1):184-201 [PubMed]
Holleboom AG, Jakulj L, Franssen R, Decaris J, Vergeer M, Koetsveld J, Luchoomun J, Glass A, Hellerstein MK, Kastelein JJP, Hovingh GK, Kuivenhoven JA, Groen AK, Turner SM, Stroes ESG, In vivo tissue cholesterol efflux is reduced in carriers of a mutation in APOA1. J LIPID RES 2013;54 (7):1964-1971 [PubMed]
Hovingh GK, Davidson MH, Kastelein JJP, O'Connor AM, Diagnosis and treatment of familial hypercholesterolaemia. EUR HEART J 2013;34 (13):962-971 [PubMed]
Hovingh K, Besseling J, Kastelein J, Efficacy and safety of mipomersen sodium (Kynamro). EXPERT OPIN DRUG SAF 2013;12 (4):569-579 [PubMed]
Huijgen R, Boekholdt SM, Arsenault BJ, Bao W, Davaine JM, Tabet F, Petrides F, Rye KA, Demicco DA, Barter PJ, Kastelein JJP, Lambert G, Plasma PCSK9 levels and clinical outcomes in the TNT (Treating to New Targets) Trial (Retraction of vol 59, pg 1778, 2012). J AM COLL CARDIOL 2013;61 (16):1751
Kastelein JJP, Ross CJD, Hayden MR, From mutation identification to therapy: discovery and origins of the first approved gene therapy in the Western world. HUM GENE THER 2013;24 (5):472-478 [PubMed]
Kusters DM, Avis HJ, Braamskamp MJ, Huijgen R, Wijburg FA, Kastelein JJ, Wiegman A, Hutten BA, Inheritance pattern of familial hypercholesterolemia and markers of cardiovascular risk. J LIPID RES 2013;54 (9):2543-2549 [PubMed]
Kusters DM, Hutten BA, McCrindle BW, Cassiman D, Francis GA, Gagné C, Gaudet D, Morrison KM, Langslet G, Kastelein JJ, Wiegman A, Design and baseline data of a pediatric study with rosuvastatin in familial hypercholesterolemia. J CLIN LIPIDOL 2013;7 (5):408-413 [PubMed]
Nicholls SJ, Bakris GL, Kastelein JJP, Menon V, Williams B, Armbrecht J, Brunel P, Nicolaides M, Hsu A, Hu B, Fang H, Puri R, Uno K, Kataoka Y, Bash D, Nissen SE, Effect of Aliskiren on Progression of Coronary Disease in Patients With Prehypertension The AQUARIUS Randomized Clinical Trial. JAMA-J AM MED ASSOC 2013;310 (11):1135-1144 [PubMed]
Oosterveer DM, Versmissen J, Defesche JC, Sivapalaratnam S, Yazdanpanah M, Mulder M, van der Zee L, Uitterlinden AG, van Duijn CM, Hofman A, Kastelein JJP, Aulchenko YS, Sijbrands EJG, Low-density lipoprotein receptor mutations generate synthetic genome-wide associations. EUR J HUM GENET 2013;21 (5):563-566 [PubMed]
Rashid S, Kastelein JJP, PCSK9 and resistin at the crossroads of the atherogenic dyslipidemia. EXPERT REV CARDIOVASC THER 2013;11 (11):1567-1577 [PubMed]
Ridker PM, Kastelein JJP, Genest J, Koenig W, C-reactive protein and cholesterol are equally strong predictors of cardiovascular risk and both are important for quality clinical care. EUR HEART J 2013;34 (17):1258-1261 [PubMed]
Rosenstock J, Marx N, Kahn SE, Zinman B, Kastelein JJ, Lachin JM, Bluhmki E, Patel S, Johansen OE, Woerle HJ, Cardiovascular outcome trials in type 2 diabetes and the sulphonylurea controversy: rationale for the active-comparator CAROLINA trial. DIABETES VASC DIS RE 2013;10 (4):289-301 [PubMed]
Singaraja RR, Sivapalaratnam S, Hovingh K, Dubé MP, Castro-Perez J, Collins HL, Adelman SJ, Riwanto M, Manz J, Hubbard B, Tietjen I, Wong K, Mitnaul LJ, van Heek M, Lin L, Roddy TA, McEwen J, Dallinge-Thie G, van Vark-van der Zee L, Verwoert G, Winther M, van Duijn C, Hofman A, Trip MD, Marais AD, Asztalos B, Landmesser U, Sijbrands E, Kastelein JJ, Hayden MR, The impact of partial and complete loss-of-function mutations in endothelial lipase on high-density lipoprotein levels and functionality in humans. CIRC-CARDIOVASC GENE 2013;6 (1):54-62 [PubMed]
Sondermeijer BM, Boekholdt SM, Rana JS, Kastelein JJP, Wareham NJ, Khaw KT, Clinical implications of JUPITER in a contemporary European population: the EPIC-Norfolk prospective population study. EUR HEART J 2013;34 (18):1350-1357 [PubMed]
Sondermeijer BM, Rana JS, Arsenault BJ, Shah PK, Kastelein JJP, Wareham NJ, Boekholdt SM, Khaw KT, Non-HDL cholesterol vs. apo B for risk of coronary heart disease in healthy individuals: the EPIC-Norfolk prospective population study. EUR J CLIN INVEST 2013;43 (10):1009-1015 [PubMed]
Sorrentino V, Fouchier SW, Motazacker MM, Nelson JK, Defesche JC, Dallinga-Thie GM, Kastelein JJP, Kees Hovingh G, Zelcer N, Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein. EUR HEART J 2013;34 (17):1292-1297 [PubMed]
Stalenhoef AF, Kastelein JJP, introduction. CURR OPIN LIPIDOL 2013;24 (6):534-535
Stitziel NO, Fouchier SW, Sjouke B, Peloso GM, Moscoso AM, Auer PL, Goel A, Gigante B, Barnes TA, Melander O, Orho-Melander M, Duga S, Sivapalaratnam S, Nikpay M, Martinelli N, Girelli D, Jackson RD, Kooperberg C, Lange LA, Ardissino D, McPherson R, Farrall M, Watkins H, Reilly MP, Rader DJ, de Faire U, Schunkert H, Erdmann J, Samani NJ, Charnas L, Altshuler D, Gabriel S, Kastelein JJP, Defesche JC, Nederveen AJ, Kathiresan S, Hovingh GK, Exome Sequencing and Directed Clinical Phenotyping Diagnose Cholesterol Ester Storage Disease Presenting as Autosomal Recessive Hypercholesterolemia. ARTERIOSCL THROM VAS 2013;33 (12):2909-2914 [PubMed]
Stoekenbroek RM, Kastelein JJP, Hovingh GK, Recent failures in antiatherosclerotic drug development: examples from the thyroxin receptor agonist, the secretory phospholipase A2 antagonist, and the acyl coenzyme A: cholesterol acyltransferase inhibitor programs. CURR OPIN LIPIDOL 2013;24 (6):459-466 [PubMed]
Tikkanen MJ, Fayyad R, Faergeman O, Olsson AG, Wun CC, Laskey R, Kastelein JJ, Holme I, Pedersen TR, Effect of intensive lipid lowering with atorvastatin on cardiovascular outcomes in coronary heart disease patients with mild-to-moderate baseline elevations in alanine aminotransferase levels. INT J CARDIOL 2013;168 (4):3846-3852 [PubMed]
van Capelleveen JC, Bochem AE, Motazacker MM, Hovingh GK, Kastelein JJP, Genetics of HDL-C: a causal link to atherosclerosis?. CURR ATHEROSCLER REP 2013;15 (6):326 [PubMed]
van Wijk DF, Boekholdt SM, Wareham NJ, Ahmadi-Abhari S, Kastelein JJP, Stroes ESG, Khaw KT, C-Reactive Protein, Fatal and Nonfatal Coronary Artery Disease, Stroke, and Peripheral Artery Disease in the Prospective EPIC-Norfolk Cohort Study. ARTERIOSCL THROM VAS 2013;33 (12):2888-2894 [PubMed]
Waters DD, Ho JE, Boekholdt SM, Demicco DA, Kastelein JJP, Messig M, Breazna A, Pedersen TR, Cardiovascular event reduction versus new-onset diabetes during atorvastatin therapy: effect of baseline risk factors for diabetes. J AM COLL CARDIOL 2013;61 (2):148-152 [PubMed]
Westerink J, Deanfield JE, Imholz BP, Spiering W, Basart DC, Coll B, Kastelein JJP, Visseren FLJ, High-dose statin monotherapy versus low-dose statin/ezetimibe combination on fasting and postprandial lipids and endothelial function in obese patients with the metabolic syndrome: The PANACEA study. ATHEROSCLEROSIS 2013;227 (1):118-124 [PubMed]
Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K, Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkilä K, Hyppönen E, Isaacs A, Jackson AU, Johansson A, Johnson T, Kaakinen M, Kettunen J, Kleber ME, Li X, Luan Ja, Lyytikäinen LP, Magnusson PKE, Mangino M, Mihailov E, Montasser ME, Müller-Nurasyid M, Nolte IM, O'Connell JR, Palmer CD, Perola M, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, van den Herik EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher D, Asiki G, Barroso I, Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney ASF, Döring A, Elliott P, Epstein SE, Eyjolfsson GI, Gigante B, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hallmans G, Hartikainen AL, Hayward C, Hernandez D, Hicks AA, Holm H, Hung YJ, Illig T, Jones MR, Kaleebu P, Kastelein JJP, Khaw KT, Kim E, Klopp N, Komulainen P, Kumari M, Langenberg C, Lehtimäki T, Lin SY, Lindström J, Loos RJF, Mach F, McArdle WL, Meisinger C, Mitchell BD, Müller G, Nagaraja R, Narisu N, Nieminen TVM, Nsubuga RN, Olafsson I, Ong KK, Palotie A, Papamarkou T, Pomilla C, Pouta A, Rader DJ, Reilly MP, Ridker PM, Rivadeneira F, Rudan I, Ruokonen A, Samani N, Scharnagl H, Seeley J, Silander K, Stancáková A, Stirrups K, Swift AJ, Tiret L, Uitterlinden AG, van Pelt LJ, Vedantam S, Wainwright N, Wijmenga C, Wild SH, Willemsen G, Wilsgaard T, Wilson JF, Young EH, Zhao JH, Adair LS, Arveiler D, Assimes TL, Bandinelli S, Bennett F, Bochud M, Boehm BO, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier M, Campbell H, Chakravarti A, Chambers JC, Chen YDI, Collins FS, Cooper RS, Danesh J, Dedoussis G, de Faire U, Feranil AB, Ferrières J, Ferrucci L, Freimer NB, Gieger C, Groop LC, Gudnason V, Gyllensten U, Hamsten A, Harris TB, Hingorani A, Hirschhorn JN, Hofman A, Hovingh GK, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Iribarren C, Järvelin MR, Jula A, Kähönen M, Kaprio J, Kesäniemi A, Kivimaki M, Kooner JS, Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J, Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren CM, Martin NG, März W, McCarthy MI, McKenzie CA, Meneton P, Metspalu A, Moilanen L, Morris AD, Munroe PB, Njølstad I, Pedersen NL, Power C, Pramstaller PP, Price JF, Psaty BM, Quertermous T, Rauramaa R, Saleheen D, Salomaa V, Sanghera DK, Saramies J, Schwarz PEH, Sheu WHH, Shuldiner AR, Siegbahn A, Spector TD, Stefansson K, Strachan DP, Tayo BO, Tremoli E, Tuomilehto J, Uusitupa M, van Duijn CM, Vollenweider P, Wallentin L, Wareham NJ, Whitfield JB, Wolffenbuttel BHR, Ordovas JM, Boerwinkle E, Palmer CNA, Thorsteinsdottir U, Chasman DI, Rotter JI, Franks PW, Ripatti S, Cupples LA, Sandhu MS, Rich SS, Boehnke M, Deloukas P, Kathiresan S, Mohlke KL, Ingelsson E, Abecasis GR, Discovery and refinement of loci associated with lipid levels. NAT GENET 2013;45 (11):1274-1283 [PubMed]
Arsenault BJ, Boekholdt SM, Hovingh GK, Hyde CL, Demicco DA, Chatterjee A, Barter P, Deedwania P, Waters DD, LaRosa JC, Pedersen TR, Kastelein JJP, The 719Arg Variant of KIF6 and Cardiovascular Outcomes in Statin-Treated, Stable Coronary Patients of the Treating to New Targets and Incremental Decrease in End Points Through Aggressive Lipid-Lowering Prospective Studies. CIRC-CARDIOVASC GENE 2012;5 (1):51-57 [PubMed]
Arsenault BJ, Boekholdt SM, Tardif JC, Kastelein JJP, De-risking the clinical development of cholesteryl ester transfer protein inhibitors: how much is good enough?. EUR HEART J 2012;33 (13):1548-1550 [PubMed]
Asselbergs FW, Guo Y, van Iperen EPA, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B, Appelman YE, Barnard J, Baumert J, Beitelshees AL, Bhangale TR, Chen YDI, Gaunt TR, Gong Y, Hopewell JC, Johnson T, Kleber ME, Langaee TY, Li M, Li YR, Liu K, McDonough CW, Meijs MFL, Middelberg RPS, Musunuru K, Nelson CP, O'Connell JR, Padmanabhan S, Pankow JS, Pankratz N, Rafelt S, Rajagopalan R, Romaine SPR, Schork NJ, Shaffer J, Shen H, Smith EN, Tischfield SE, van der Most PJ, van Vliet-Ostaptchouk JV, Verweij N, Volcik KA, Zhang L, Bailey KR, Bailey KM, Bauer F, Boer JMA, Braund PS, Burt A, Burton PR, Buxbaum SG, Chen W, Cooper-DeHoff RM, Cupples LA, Dejong JS, Delles C, Duggan D, Fornage M, Furlong CE, Glazer N, Gums JG, Hastie C, Holmes MV, Illig T, Kirkland SA, Kivimaki M, Klein R, Klein BE, Kooperberg C, Kottke-Marchant K, Kumari M, LaCroix AZ, Mallela L, Murugesan G, Ordovas J, Ouwehand WH, Post WS, Saxena R, Scharnagl H, Schreiner PJ, Shah T, Shields DC, Shimbo D, Srinivasan SR, Stolk RP, Swerdlow DI, Taylor HA Jr, Topol EJ, Toskala E, van Pelt JL, van Setten J, Yusuf S, Whittaker JC, Zwinderman AH, Anand SS, Balmforth AJ, Berenson GS, Bezzina CR, Boehm BO, Boerwinkle E, Casas JP, Caulfield MJ, Clarke R, Connell JM, Cruickshanks KJ, Davidson KW, Day INM, de Bakker PIW, Doevendans PA, Dominiczak AF, Hall AS, Hartman CA, Hengstenberg C, Hillege HL, Hofker MH, Humphries SE, Jarvik GP, Johnson JA, Kaess BM, Kathiresan S, Koenig W, Lawlor DA, März W, Melander O, Mitchell BD, Montgomery GW, Munroe PB, Murray SS, Newhouse SJ, Onland-Moret NC, Poulter N, Psaty B, Redline S, Rich SS, Rotter JI, Schunkert H, Sever P, Shuldiner AR, Silverstein RL, Stanton A, Thorand B, Trip MD, Tsai MY, van der Harst P, van der Schoot E, van der Schouw YT, Verschuren WMM, Watkins H, Wilde AAM, Wolffenbuttel BHR, Whitfield JB, Hovingh GK, Ballantyne CM, Wijmenga C, Reilly MP, Martin NG, Wilson JG, Rader DJ, Samani NJ, Reiner AP, Hegele RA, Kastelein JJP, Hingorani AD, Talmud PJ, Hakonarson H, Elbers CC, Keating BJ, Drenos F [Contributors: de Boer R, Hillege H, van der Klauw M, Navis G, Ormel H, Postma D, Rosmalen J, Slaets J, Stolk R, Wolffenbuttel B, Alizadeh B, Boezen M, Bruinenberg M, Festen N, Franke L, van der Harst P, Snieder H, Wijmenga C]] , Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci. AM J HUM GENET 2012;91 (5):823-838 [PubMed]
Avis HJ, Kusters DM, Vissers MN, Huijgen R, Janssen TH, Wiegman A, Kindt I, Kastelein JJP, Wijburg FA, Hutten BA, Follow-Up of Children Diagnosed with Familial Hypercholesterolemia in a National Genetic Screening Program. J PEDIATR-US 2012;161 (1):99-103 [PubMed]
Ballantyne CM, Bays HE, Kastelein JJ, Stein E, Isaacsohn JL, Braeckman RA, Soni PN, Efficacy and Safety of Eicosapentaenoic Acid Ethyl Ester (AMR101) Therapy in Statin-Treated Patients With Persistent High Triglycerides (from the ANCHOR Study). AM J CARDIOL 2012;110 (7):984-992 [PubMed]
Barter PJ, Rye KA, Beltangady MS, Ports WC, Duggan WT, Boekholdt SM, Demicco DA, Kastelein JJP, Shear CL, Relationship between atorvastatin dose and the harm caused by torcetrapib. J LIPID RES 2012;53 (11):2436-2442 [PubMed]
Bays HE, Braeckman RA, Ballantyne CM, Kastelein JJ, Otvos JD, Stirtan WG, Soni PN, Icosapent ethyl, a pure EPA omega-3 fatty acid: Effects on lipoprotein particle concentration and size in patients with very high triglyceride levels (the MARINE study). J CLIN LIPIDOL 2012;6 (6):565-572 [PubMed]
Boekholdt SM, Arsenault BJ, Mora S, Pedersen TR, LaRosa JC, Nestel PJ, Simes RJ, Durrington P, Hitman GA, Welch KMA, Demicco DA, Zwinderman AH, Clearfield MB, Downs JR, Tonkin AM, Colhoun HM, Gotto AM Jr, Ridker PM, Kastelein JJP, Association of LDL Cholesterol, Non-HDL Cholesterol, and Apolipoprotein B Levels With Risk of Cardiovascular Events Among Patients Treated With Statins A Meta-analysis. JAMA-J AM MED ASSOC 2012;307 (12):1302-1309 [PubMed]
Boekholdt SM, Kastelein JJP, Lipid Parameters and Cardiovascular Events in Patients Taking Statins Reply. JAMA-J AM MED ASSOC 2012;308 (2):132-133
Bots ML, Taylor AJ, Kastelein JJP, Peters SAE, den Ruijter HM, Tegeler CH, Baldassarre D, Stein JH, O'Leary DH, Revkin JH, Grobbee DE, Rate of change in carotid intima-media thickness and vascular events: meta-analyses can not solve all the issues. A point of view. J HYPERTENS 2012;30 (9):1690-1696 [PubMed]
Brunham LR, Lansberg PJ, Zhang L, Miao F, Carter C, Hovingh GK, Visscher H, Jukema JW, Stalenhoef AF, Ross CJD, Carleton BC, Kastelein JJP, Hayden MR, Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin. PHARMACOGENOMICS J 2012;12 (3):233-237 [PubMed]
Chapman MJ, Kastelein JJP, Pitavastatin: a new option for the reduction of cardiovascular risk factors. CLIN LIPIDOL 2012;7 (3 1):1
Clarke R, Bennett DA, Parish S, Verhoef P, Dötsch-Klerk M, Lathrop M, Xu P, Nordestgaard BG, Holm H, Hopewell JC, Saleheen D, Tanaka T, Anand SS, Chambers JC, Kleber ME, Ouwehand WH, Yamada Y, Elbers C, Peters B, Stewart AFR, Reilly MM, Thorand B, Yusuf S, Engert JC, Assimes TL, Kooner J, Danesh J, Watkins H, Samani NJ, Collins R, Peto R [Contributors: Holm H, Thorsteinsdottir U, Gretarsdottir S, Gulcher JR, Thorgeirsson G, Andersen K, Stefansson K, Parish S, Bennett DA, Clarke R, Peto R, Sleight P, Collins R, Hopewell JC, Watkins H, Saleheen D, Danesh J, Rasheed A, Zaidi M, Frossard P, Shah N, Samuel M, Tanaka T, Ozaki K, Sato H, Sakata Y, Komuro I, Anand SS, Yusuf S, Engert JC, Chambers J, Kooner J, Armitage J, Samani NJ, Braund PS, Nelson CP, Hall AS, Balmforth A, Ball SG, Kleber ME, Hoffmann MM, März WA, Bugert P, Winkelmann B, Böhm BO, Ouwehand WH, Sivapalaratnam S, Kastelein JJ, Trip MD, Bezzina CR, Ouwehand W, Yamada Y, Elbers CC, Onland-Moret NC, Bauer F, van der Schouw YT, Verschuren WM, de Boer JM, Wijmenga C, Hofker MH, de Bakker PIW, Peters BJM, Maitland-van der Zee AH, de Boer A, Klungel OH, Grobbee DE, Stewart AFR, Roberts R, McPherson R, Chen L, Wells GA, Reilly MM, Li M, Qu I, Rader DJ, Thorand B, Illig T, Peters A, Koenig W, Assimes TL, Fortmann S, Iribarren C, Abbate R, Marcucci R, Anderson JL, Zebrack JS, Ardissino D, Merlini FM, Bonomi AB, Ashfield-Watt PAL, Clark ZE, van Bockxmeer FM, Brownrigg L, Kooner JS, Ferrer-Antunes C, Palmeiro A, Fernandez-Arcas N, Reyes-Engel A, Folsom AR, Fowkes FGR, Lee AJ, Gaziano JM, Gemmati D, Scapoli GL, Genest J, Rozen R, Girelli D, Corrocher R, Rossi GB, Meleady R, Graham IM, Gulec S, Hopkins PN, Inbal A, Selighson U, Jukema JW, Litynsky P, Kluijtmans LAJ, Kozich V, Janosikova B, Ma J, Stampfer MJ, Malinow MR, Meisel C, Stangl K, Morita H, Nagai R, Nakai K, Nordestgaard BG, Zacho J, Rimm EB, Schwartz SM, Siscovick DS, Silberberg JS, Szczeklik A, Domagala BT, Tanis BC, Rosendaal FM, Thogersen AM, Nilsson TK, Todesco L, Tokgozoglu SL, Tsai MY, Hanson NQ, Verhoeff BJ, Yamakawa-Kobayashi K, Hamaguchi H]] , Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias. PLOS MED 2012;9 (2):e1001177 [PubMed]
Dastani Z, Hivert MF, Timpson N, Perry JRB, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, Beekman M, Coassin S, Lohman K, Qi L, Kanoni S, Pankow JS, Uh HW, Wu Y, Bidulescu A, Rasmussen-Torvik LJ, Greenwood CMT, Ladouceur M, Grimsby J, Manning AK, Liu CT, Kooner J, Mooser VE, Vollenweider P, Kapur KA, Chambers J, Wareham NJ, Langenberg C, Frants R, Willems-Vandijk K, Oostra BA, Willems SM, Lamina C, Winkler TW, Psaty BM, Tracy RP, Brody J, Chen I, Viikari J, Kähönen M, Pramstaller PP, Evans DM, St Pourcain B, Sattar N, Wood AR, Bandinelli S, Carlson OD, Egan JM, Böhringer S, van Heemst D, Kedenko L, Kristiansson K, Nuotio ML, Loo BM, Harris T, Garcia M, Kanaya A, Haun M, Klopp N, Wichmann HE, Deloukas P, Katsareli E, Couper DJ, Duncan BB, Kloppenburg M, Adair LS, Borja JB, Wilson JG, Musani S, Guo X, Johnson T, Semple R, Teslovich TM, Allison MA, Redline S, Buxbaum SG, Mohlke KL, Meulenbelt I, Ballantyne CM, Dedoussis GV, Hu FB, Liu Y, Paulweber B, Spector TD, Slagboom PE, Ferrucci L, Jula A, Perola M, Raitakari O, Florez JC, Salomaa V, Eriksson JG, Frayling TM, Hicks AA, Lehtimäki T, Smith GD, Siscovick DS, Kronenberg F, van Duijn C, Loos RJF, Waterworth DM, Meigs JB, Dupuis J, Richards JB, Voight BF, Scott LJ, Steinthorsdottir V, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, Mcculloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, Mccarroll SA, Hofmann OM, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Boström KB, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Crawford G, Doney ASF, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PRV, Jørgensen T, Kao WHL, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Petersen AK, Platou C, Proença C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsø T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Walters GB, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Morris AD, Palmer CNA, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Pedersen O, Barroso I, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI, Soranzo N, Wheeler E, Glazer NL, Bouatia-Naji N, Mägi R, Randall J, Elliott P, Rybin D, Dehghan A, Hottenga JJ, Song K, Goel A, Lajunen T, Doney A, Cavalcanti-Proença C, Kumari M, Timpson NJ, Zabena C, Ingelsson E, An P, O'Connell J, Luan Ja, Elliott A, McCarroll SA, Roccasecca RM, Pattou F, Sethupathy P, Ariyurek Y, Barter P, Beilby JP, Ben-Shlomo Y, Bergmann S, Bochud M, Bonnefond A, Borch-Johnsen K, Böttcher Y, Brunner E, Bumpstead SJ, Chen YDI, Chines P, Clarke R, Coin LJM, Cooper MN, Crisponi L, Day INM, de Geus EJC, Delplanque J, Fedson AC, Fischer-Rosinsky A, Forouhi NG, Franzosi MG, Galan P, Goodarzi MO, Graessler J, Grundy S, Gwilliam R, Hallmans G, Hammond N, Han X, Hartikainen AL, Hayward C, Heath SC, Hercberg S, Hillman DR, Hingorani AD, Hui J, Hung J, Kaakinen M, Kaprio J, Kesaniemi YA, Kivimaki M, Knight B, Koskinen S, Kovacs P, Kyvik KO, Lathrop GM, Lawlor DA, Le Bacquer O, Lecoeur C, Li Y, Mahley R, Mangino M, Martínez-Larrad MT, McAteer JB, McPherson R, Meisinger C, Melzer D, Meyre D, Mitchell BD, Mukherjee S, Naitza S, Neville MJ, Orrù M, Pakyz R, Paolisso G, Pattaro C, Pearson D, Peden JF, Pedersen NL, Pfeiffer AFH, Pichler I, Polasek O, Posthuma D, Potter SC, Pouta A, Province MA, Rayner NW, Rice K, Ripatti S, Rivadeneira F, Rolandsson O, Sandbaek A, Sandhu M, Sanna S, Sayer AA, Scheet P, Seedorf U, Sharp SJ, Shields B, Sigurðsson G, Sijbrands EJG, Silveira A, Simpson L, Singleton A, Smith NL, Sovio U, Swift A, Syddall H, Syvänen AC, Tönjes A, Uitterlinden AG, van Dijk KW, Varma D, Visvikis-Siest S, Vitart V, Vogelzangs N, Waeber G, Wagner PJ, Walley A, Ward KL, Watkins H, Wild SH, Willemsen G, Witteman JCM, Yarnell JWG, Zelenika D, Zethelius B, Zhai G, Zhao JH, Zillikens MC, Borecki IB, Meneton P, Magnusson PKE, Nathan DM, Williams GH, Silander K, Bornstein SR, Schwarz P, Spranger J, Karpe F, Shuldiner AR, Cooper C, Serrano-Ríos M, Lind L, Palmer LJ, Hu FB 1st, Franks PW, Ebrahim S, Marmot M, Kao WHL, Pramstaller PP, Wright AF, Stumvoll M, Hamsten A, Buchanan TA, Valle TT, Rotter JI, Penninx BWJH, Boomsma DI, Cao A, Scuteri A, Schlessinger D, Uda M, Ruokonen A, Jarvelin MR, Peltonen L, Mooser V, Sladek R, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Chasman DI, Johansen CT, Fouchier SW, Peloso GM, Barbalic M, Ricketts SL, Bis JC, Feitosa MF, Orho-Melander M, Melander O, Li X, Li M, Cho YS, Go MJ, Kim YJ, Lee JY, Park T, Kim K, Sim X, Ong RTH, Croteau-Chonka DC, Lange LA, Smith JD, Ziegler A, Zhang W, Zee RYL, Whitfield JB, Thompson JR, Surakka I, Spector TD, Smit JH, Sinisalo J, Scott J, Saharinen J, Sabatti C, Rose LM, Roberts R, Rieder M, Parker AN, Pare G, O'Donnell CJ, Nieminen MS, Nickerson DA, Montgomery GW, McArdle W, Masson D, Martin NG, Marroni F, Lucas G, Luben R, Lokki ML, Lettre G, Launer LJ, Lakatta EG, Laaksonen R, Kyvik KO, König IR, Khaw KT, Kaplan LM, Johansson Å, Janssens ACJW, Igl W, Hovingh GK, Hengstenberg C, Havulinna AS, Hastie ND, Harris TB, Haritunians T, Hall AS, Groop LC, Gonzalez E, Freimer NB, Erdmann J, Ejebe KG, Döring A, Dominiczak AF, Demissie S, Deloukas P, de Faire U, Crawford G, Chen YdI, Caulfield MJ, Boekholdt SM, Assimes TL, Quertermous T, Seielstad M, Wong TY, Tai ES, Feranil AB, Kuzawa CW, Taylor HA Jr, Gabriel SB, Holm H, Gudnason V, Krauss RM, Ordovas JM, Munroe PB, Kooner JS, Tall AR, Hegele RA, Kastelein JJP, Schadt EE, Strachan DP, Reilly MP, Samani NJ, Schunkert H, Cupples LA, Sandhu MS, Ridker PM, Rader DJ, Kathiresan S [Contributors: Olson J, Kronmal R, Robbins J, Chaves PH, Burke G, Kuller LH, Tracy R, Gottdiener J, Prineas R, Becker JT, Enright P, Klein R, O'Leary DH]] , Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLOS GENET 2012;8 (3):e1002607 [PubMed]
Gaudet D, Méthot J, Kastelein J, Gene therapy for lipoprotein lipase deficiency. CURR OPIN LIPIDOL 2012;23 (4):310-320 [PubMed]
Gitt AK, Drexel H, Feely J, Ferrières J, Gonzalez-Juanatey JR, Thomsen KK, Leiter LA, Lundman P, da Silva PM, Pedersen T, Wood D, Jünger C, Dellea PS, Sazonov V, Chazelle F, Kastelein JJP, Persistent lipid abnormalities in statin-treated patients and predictors of LDL-cholesterol goal achievement in clinical practice in Europe and Canada. EUR J PREV CARDIOL 2012;19 (2):221-230 [PubMed]
Holleboom AG, Daniil G, Fu X, Zhang R, Hovingh GK, Schimmel AW, Kastelein JJP, Stroes ESG, Witztum JL, Hutten BA, Tsimikas S, Hazen SL, Chroni A, Kuivenhoven JA, Lipid Oxidation in Carriers of Lecithin: Cholesterol Acyltransferase Gene Mutations. ARTERIOSCL THROM VAS 2012;32 (12):3066-+ [PubMed]
Huijgen R. Familial hypercholesterolemia: the Dutch approach. s.l.: s.n.; 2012. 405p. ISBN 9789461083722 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP, van Rijckevorsel JLA; copromotor(s): Hutten BA, Vissers MN)
Huijgen R, Boekholdt SM, Arsenault BJ, Bao W, Davaine JM, Tabet F, Petrides F, Rye KA, Demicco DA, Barter PJ, Kastelein JJP, Lambert G, Plasma PCSK9 Levels and Clinical Outcomes in the TNT (Treating to New Targets) Trial (Retracted article. See vol. 61, pg. 1751, 2013). J AM COLL CARDIOL 2012;59 (20):1778-1784 [PubMed]
Huijgen R, Fouchier SW, Denoun M, Hutten BA, Vissers MN, Lambert G, Kastelein JJP, Plasma levels of PCSK9 and phenotypic variability in familial hypercholesterolemia. J LIPID RES 2012;53 (5):979-983 [PubMed]
Huijgen R, Homsma SJM, Hutten BA, Kindt I, Vissers MN, Kastelein JJP, van Rijckevorsel JLA, Improved access to life insurance after genetic diagnosis of familial hypercholesterolaemia: cross-sectional postal questionnaire study. EUR J HUM GENET 2012;20 (7):722-728 [PubMed]
Huijgen R, Hutten BA, Kindt I, Vissers MN, Kastelein JJP, Discriminative Ability of LDL-Cholesterol to Identify Patients With Familial Hypercholesterolemia. CIRC-CARDIOVASC GENE 2012;5 (3):354-359 [PubMed]
Huijgen R, Kindt I, Defesche JC, Kastelein JJP, Cardiovascular risk in relation to functionality of sequence variants in the gene coding for the low-density lipoprotein receptor: a study among 29 365 individuals tested for 64 specific low-density lipoprotein-receptor sequence variants. EUR HEART J 2012;33 (18):2325-2330 [PubMed]
Huijgen R, Sjouke B, Vis K, de Randamie JSE, Defesche JC, Kastelein JJP, Hovingh GK, Fouchier SW, Genetic Variation in APOB, PCSK9, and ANGPTL3 in Carriers of Pathogenic Autosomal Dominant Hypercholesterolemic Mutations with Unexpected Low LDL-C Levels. HUM MUTAT 2012;33 (2):448-455 [PubMed]
Huijgen R, Stork ADM, Defesche JC, Peter J, Alonso R, Cuevas A, Kastelein JJP, Duran M, Stroes ESG, Extreme xanthomatosis in patients with both familial hypercholesterolemia and cerebrotendinous xanthomatosis. CLIN GENET 2012;81 (1):24-28 [PubMed]
Kastelein JJP, Braamskamp M, Pitavastatin: an overview of the LIVES study. CLIN LIPIDOL 2012;7 (3 1):25-31
Kusters DM, Lahsinoui HH, van de Post JAM, Wiegman A, Wijburg FA, Kastelein JJP, Hutten BA, Statin use during pregnancy: a systematic review and meta-analysis. EXPERT REV CARDIOVASC THER 2012;10 (3):363-378 [PubMed]
Lambert G, Sjouke B, Choque B, Kastelein JJP, Hovingh GK, The PCSK9 decade. J LIPID RES 2012;53 (12):2515-2524 [PubMed]
Landmesser U, von Eckardstein A, Kastelein J, Deanfield J, Lüscher TF, Increasing high-density lipoprotein cholesterol by cholesteryl ester transfer protein-inhibition: a rocky road and lessons learned? The early demise of the dal-HEART programme. EUR HEART J 2012;33 (14):1712-1715 [PubMed]
Lüscher TF, Taddei S, Kaski JC, Jukema JW, Kallend D, Münzel T, Kastelein JJP, Deanfield JE [Contributors: Noll G, Mocetti T, Taddei S, Fichtlscherer S, Münzel T, Drexel H, Simon A, Trip MD, Basart DCG, Visseren FLJ, Liem AH, van Kempen W, Jonker J, Kose V, Lokhorst B, Agous I, Tiebesl J, Hoogendijk J, de Schipper L]] , Vascular effects and safety of dalcetrapib in patients with or at risk of coronary heart disease: the dal-VESSEL randomized clinical trial. EUR HEART J 2012;33 (7):857-+ [PubMed]
Mora S, Glynn RJ, Boekholdt SM, Nordestgaard BG, Kastelein JJP, Ridker PM, On-Treatment Non-High-Density Lipoprotein Cholesterol, Apolipoprotein B, Triglycerides, and Lipid Ratios in Relation to Residual Vascular Risk After Treatment With Potent Statin Therapy JUPITER (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin). J AM COLL CARDIOL 2012;59 (17):1521-1528 [PubMed]
Mora S, Wenger NK, Demicco DA, Breazna A, Boekholdt SM, Arsenault BJ, Deedwania P, Kastelein JJP, Waters DD, Determinants of residual risk in secondary prevention patients treated with high- versus low-dose statin therapy: the Treating to New Targets (TNT) study. CIRCULATION 2012;125 (16):1979-1987 [PubMed]
Motazacker MM, Pirruccello J, Huijgen R, Do R, Gabriel S, Peter J, Kuivenhoven JA, Defesche JC, Kastelein JJP, Hovingh GK, Zelcer N, Kathiresan S, Fouchier SW, Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia. EUR HEART J 2012;33 (11):1360-1366 [PubMed]
Mulders TA, Sivapalaratnam S, Stroes ESG, Kastelein JJP, Guerci AD, Pinto-Sietsma SJ, Asymptomatic Individuals With a Positive Family History for Premature Coronary Artery Disease and Elevated Coronary Calcium Scores Benefit From Statin Treatment A Post Hoc Analysis From the St. Francis Heart Study. JACC-CARDIOVASC IMAG 2012;5 (3):252-260 [PubMed]
Nicholls SJ, Cavender MA, Kastelein JJP, Schwartz G, Waters DD, Rosenson RS, Bash D, Hislop C, Inhibition of Secretory Phospholipase A(2) in Patients with Acute Coronary Syndromes: Rationale and Design of the Vascular Inflammation Suppression to Treat Acute Coronary Syndrome for 16 Weeks (VISTA-16) Trial. CARDIOVASC DRUG THER 2012;26 (1):71-75 [PubMed]
Nicholls SJ, Gordon A, Johannson J, Ballantyne CM, Barter PJ, Brewer HB, Kastelein JJP, Wong NC, Borgman MRN, Nissen SE, ApoA-I Induction as a Potential Cardioprotective Strategy: Rationale for the SUSTAIN and ASSURE Studies. CARDIOVASC DRUG THER 2012;26 (2):181-187 [PubMed]
Nieuwkerk PT, Nierman MC, Vissers MN, Locadia M, Greggers-Peusch P, Knape LPM, Kastelein JJP, Sprangers MAG, de Haes HC, Stroes ESG, Intervention to Improve Adherence to Lipid-Lowering Medication and Lipid-Levels in Patients With an Increased Cardiovascular Risk. AM J CARDIOL 2012;110 (5):666-672 [PubMed]
Olivier M, Tanck MW, Out R, Villard EF, Lammers B, Bouchareychas L, Frisdal E, Superville A, van Berkel T, Kastelein JJ, Eck MV, Jukema JW, Chapman MJ, Dallinga-Thie GM, Guerin M, Goff WL, Human ATP-Binding Cassette G1 Controls Macrophage Lipoprotein Lipase Bioavailability and Promotes Foam Cell Formation. ARTERIOSCL THROM VAS 2012;32 (9):2223-+ [PubMed]
Rana JS, Boekholdt SM, Kastelein JJP, Shah PK, The Role of Non-HDL Cholesterol in Risk Stratification for Coronary Artery Disease. CURR ATHEROSCLER REP 2012;14 (2):130-134 [PubMed]
Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Gorman DN, Gao P, Saleheen D, Rendon A, Nelson CP, Braund PS, Hall AS, Chasman DI, Tybjærg-Hansen A, Chambers JC, Benjamin EJ, Franks PW, Clarke R, Wilde AAM, Trip MD, Steri M, Witteman JCM, Qi L, van der Schoot CE, de Faire U, Erdmann J, Stringham HM, Koenig W, Rader DJ, Melzer D, Reich D, Psaty BM, Kleber ME, Panagiotakos DB, Willeit J, Wennberg P, Woodward M, Adamovic S, Rimm EB, Meade TW, Gillum RF, Shaffer JA, Hofman A, Onat A, Sundström J, Wassertheil-Smoller S, Mellström D, Gallacher J, Cushman M, Tracy RP, Kauhanen J, Karlsson M, Salonen JT, Wilhelmsen L, Amouyel P, Cantin B, Best LG, Ben-Shlomo Y, Manson JE, Davey-Smith G, de Bakker PIW, O'Donnell CJ, Wilson JF, Wilson AG, Assimes TL, Jansson JO, Ohlsson C, Tivesten Å, Ljunggren Ö, Reilly MP, Hamsten A, Ingelsson E, Cambien F, Hung J, Thomas GN, Boehnke M, Schunkert H, Asselbergs FW, Kastelein JJP, Gudnason V, Salomaa V, Harris TB, Kooner JS, Allin KH, Nordestgaard BG, Hopewell JC, Goodall AH, Ridker PM, Hólm H, Watkins H, Ouwehand WH, Samani NJ, Kaptoge S, Di Angelantonio E, Harari O, Danesh J [Contributors: Assimes TL, Quertermous T, Go AS, Hlatky MA, Knowles JW, Gudnason V, Smith AV, Panagiotakos DB, Chrysohoou C, Pitsavos C, Stefanadis C, Nelson CP, Braund PS, Samani NJ, Hall AS, Balmforth AJ, Thompson JR, Rendon A, Wilde AAM, Trip MD, van der Schoot CE, Kastelein JJP, Ouwehand WH, Sivapalaratnam S, Maiwald S, Basart H, Motazacker M, de Jong JSSG, Dekker LRC, Tanck M, Bezzina CR, Whincup PH, Morris RW, Wannamethee SG, Willeit J, Kiechl S, Gallacher J, Yarnell JWG, Lowe G, Rumley A, Goodall AH, Cambien F, Cushman M, Mukamal KJ, Nordestgaard BG, Tybjærg-Hansen A, Allin KH, Salomaa V, Havulinna AS, Lokki ML, Nieminen MS, Ripatti S, Sinisalo J, Hung J, McQuillan BM, Beilby JP, Thompson PL, Hólm H, Thorleifsson G, Thorgeirsson G, Thorsteinsdóttir U, Stefansson K, Jula A, Männistö S, Perola M, Tikkanen E, Asselbergs FW, Boer JMA, Onland-Moret NC, van der Schouw YT, Verschuren WMM, de Bakker PIW, Wennberg P, Jansson JH, Woodward M, Benjamin EJ, Dupuis J, Fontes JD, Yin X, O'Donnell CJ, Boehnke M, Stringham HM, Tuomilehto J, Schunkert H, Erdmann J, Koenig IR, Nahrstaedt J, Loley C, Stark K, Willenborg C, Hengstenberg C, Schreiber S, Preuss M, Franks PW, Barroso I, Hallmans G, Shungin D, Thomas GN, Cheng KK, Lam TH, Jiang CC, Reich D, Harris TB, Rimm EB, Pai J, Hopewell JC, Collins R, Parish S, Armitage J, Jackson A, Hveem K, Psaty BM, Wiggins KL, Heckbert SR, Smith NL, Bis JC, Melzer D, Ferrucci L, Guralnik JM, Bandinelli S, Singleton AB, Kauhanen J, Salonen JT, Tuomainen TP, Kurl S, Meade TW, Chambers JC, Kooner JS, Zhang W, Kooner AS, Das D, Kleber ME, März W, Scharnagl H, Böhm BO, Winkelmann BR, Tracy RP, Folsom AR, Shea SJ, Laakso M, Kuusisto J, Koenig W, Baumert J, Thorand B, Illig T, Meisinger C, Wilhelmsen L, Rosengren A, Jansson JO, Adamovic S, Karlsson MK, Ljunggren Ö, Mellström D, Ohlsson C, Tivesten Å, Gillum RF, Manson JE, Qi L, Hu FB, Hankinson SE, Shaffer JA, Davidson KW, Wilson JF, Fraser R, Wild S, Campbell H, Rader DJ, Reilly MP, Qasim A, Qu L, Li M, Ingelsson E, Lind L, Sundström J, Syvänen AC, Amouyel P, Arveiler D, Clarke R, Watkins H, Farrall M, Peden JF, Saleheen D, Deloukas P, Sheikh N, Rasheed A, Danesh J, Cantin B, Dagenais GR, Witteman JCM, Hofman A, Dehghan A, van Duijn CM, Uitterlinden AG, Steri M, Abecasis GR, Cucca F, Sanna S, Uda M, Schlessinger D, Hamsten A, Sabater-Lleal M, Silveira A, de Faire U, Gigante B, Best LG, Howard BV, Davey-Smith G, Ben-Shlomo Y, Onat A, Basu S, Ridker PM, Chasman DI, Rose LM, Wassertheil-Smoller S, Buring J]] , Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. LANCET 2012;379 (9822):1205-1213 [PubMed]
Sivapalaratnam S. The molecular basis of early onset cardiovascular disease. s.l.: s.n.; 2012. 276p. ISBN 9789461083326 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Levi MM, Kastelein JJP; copromotor(s): Trip MD, Ouwehand WH, Hovingh GK)
Sivapalaratnam S, Basart H, Watkins NA, Maiwald S, Rendon A, Krishnan U, Sondermeijer BM, Creemers EE, Pinto-Sietsma SJ, Hovingh K, Ouwehand WH, Kastelein JJP, Goodall AH, Trip MD, Monocyte Gene Expression Signature of Patients with Early Onset Coronary Artery Disease. PLOS ONE 2012;7 (2):e32166 [PubMed]
Sondermeijer BM. Cardiovascular metabolism. s.l.: s.n.; 2012. 201p. ISBN 9789088914782 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP, Stroes ESG; copromotor(s): Serlie MJM)
Sondermeijer BM, Klein Twennaar CF, Kastelein JJP, Franssen EJF, Hutten BA, Dallinga-Thie GM, Stroes ESG, Fliers E, Twickler MTB, Serlie MJ, Infusion of a Lipid Emulsion in Healthy Men Decreases the Serotonergic Response. NEUROENDOCRINOLOGY 2012;95 (4):325-331 [PubMed]
Surendran RP, Visser ME, Heemelaar S, Wang J, Peter J, Defesche JC, Kuivenhoven JA, Hosseini M, Péterfy M, Kastelein JJP, Johansen CT, Hegele RA, Stroes ESG, Dallinga-Thie GM, Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia. J INTERN MED 2012;272 (2):185-196 [PubMed]
Tajik P, Meijer R, Duivenvoorden R, Peters SAE, Kastelein JJ, Visseren FJ, Crouse JR 3rd, Palmer MK, Raichlen JS, Grobbee DE, Bots ML, Asymmetrical distribution of atherosclerosis in the carotid artery: identical patterns across age, race, and gender. EUR J PREV CARDIOL 2012;19 (4):687-697 [PubMed]
Tietjen I, Hovingh GK, Singaraja R, Radomski C, McEwen J, Chan E, Mattice M, Legendre A, Kastelein JJP, Hayden MR, Increased risk of coronary artery disease in Caucasians with extremely low HDL cholesterol due to mutations in ABCA1, APOA1, and LCAT. BBA-MOL CELL BIOL L 2012;1821 (3):416-424 [PubMed]
Tietjen I, Hovingh GK, Singaraja RR, Radomski C, Barhdadi A, McEwen J, Chan E, Mattice M, Legendre A, Franchini PL, Dubé MP, Kastelein JJP, Hayden MR, Segregation of LIPG, CETP, and GALNT2 Mutations in Caucasian Families with Extremely High HDL Cholesterol. PLOS ONE 2012;7 (8):e37437 [PubMed]
van den Bogaard B, Holleboom AG, Duivenvoorden R, Hutten BA, Kastelein JJP, Hovingh GK, Kuivenhoven JA, Stroes ESG, van den Born BJH, Patients with low HDL-cholesterol caused by mutations in LCAT have increased arterial stiffness. ATHEROSCLEROSIS 2012;225 (2):481-485 [PubMed]
van Leuven SI, Mendez-Fernandez YV, Wilhelm AJ, Wade NS, Gabriel CL, Kastelein JJ, Stroes ES, Tak PP, Major AS, Mycophenolate mofetil but not atorvastatin attenuates atherosclerosis in lupus-prone LDLr-/- mice. ANN RHEUM DIS 2012;71 (3):408-414 [PubMed]
Versmissen J, Oosterveer DM, Blommesteijn-Touw AC, van Vark-van der Zee L, Vongpromek R, Mulder M, Sijbrands EJG, Hoekstra M, Out R, Berbée JFP, Vanmierlo T, Defesche JC, Kastelein JJP, Response to the Letter by Singh et al Regarding "Apolipoprotein Isoform E4 Does Not Increase Coronary Heart Disease Risk in Carriers of Low-Density Lipoprotein Receptor Mutations". CIRC-CARDIOVASC GENE 2012;5 (2):E14 [PubMed]
Visser ME, Wagener G, Baker BF, Geary RS, Donovan JM, Beuers UHW, Nederveen AJ, Verheij J, Trip MD, Basart DCG, Kastelein JJP, Stroes ESG, Mipomersen, an apolipoprotein B synthesis inhibitor, lowers low-density lipoprotein cholesterol in high-risk statin-intolerant patients: a randomized, double-blind, placebo-controlled trial. EUR HEART J 2012;33 (9):1142-1149 [PubMed]
Visser ME, Witztum JL, Stroes ESG, Kastelein JJP, Antisense oligonucleotides for the treatment of dyslipidaemia. EUR HEART J 2012;33 (12):1451-1458 [PubMed]
Akdim F, Tribble DL, Flaim JD, Yu R, Su J, Geary RS, Baker BF, Fuhr R, Wedel MK, Kastelein JJP, Efficacy of apolipoprotein B synthesis inhibition in subjects with mild-to-moderate hyperlipidaemia. EUR HEART J 2011;32 (21):2650-2659 [PubMed]
Arsenault BJ, Boekholdt SM, Kastelein JJP, Lipid parameters for measuring risk of cardiovascular disease. NAT REV CARDIOL 2011;8 (4):197-206 [PubMed]
Arsenault BJ, Boekholdt SM, Kastelein JJP, Varespladib: targeting the inflammatory face of atherosclerosis. EUR HEART J 2011;32 (8):923-926 [PubMed]
Barter PJ, Rye KA, Tardif JC, Waters DD, Boekholdt SM, Breazna A, Kastelein JJP, Effect of torcetrapib on glucose, insulin, and hemoglobin A1c in subjects in the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) trial. CIRCULATION 2011;124 (5):555-562 [PubMed]
Bays HE, Ballantyne CM, Kastelein JJ, Isaacsohn JL, Braeckman RA, Soni PN, Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial). AM J CARDIOL 2011;108 (5):682-690 [PubMed]
Broekhuizen LN. Glycocalyx, cardiometabolic disease and inflammation. S.l.: s.n.; 2011. 183p. ISBN 9789461082008 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP, Vink H; copromotor(s): Stroes ESG, Nieuwdorp M)
Broekhuizen LN, Boekholdt SM, Arsenault BJ, Despres JP, Stroes ESG, Kastelein JJP, Khaw KT, Wareham NJ, Physical activity, metabolic syndrome, and coronary risk: the EPIC-Norfolk prospective population study. EUR J CARDIOV PREV R 2011;18 (2):209-217 [PubMed]
Broekhuizen LN, van Wijk DF, Vink H, Stalmach A, Crozier A, Hutten BA, Kastelein JJP, Hugenholtz PG, Koenig W, Stroes ESG, Reduction of monocyte chemoattractant protein 1 and macrophage migration inhibitory factor by a polyphenol-rich extract in subjects with clustered cardiometabolic risk factors. BRIT J NUTR 2011;106 (9):1416-1422 [PubMed]
Brunham LR, Tietjen I, Bochem AE, Singaraja RR, Franchini PL, Radomski C, Mattice M, Legendre A, Hovingh GK, Kastelein JJP, Hayden MR, Novel mutations in scavenger receptor BI associated with high HDL cholesterol in humans. CLIN GENET 2011;79 (6):575-581 [PubMed]
Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ, Kühnel B, Kumar V, Lagou V, Liang L, Luan Ja, Vidal PM, Mateo Leach I, O'Reilly PF, Peden JF, Rahmioglu N, Soininen P, Speliotes EK, Yuan X, Thorleifsson G, Alizadeh BZ, Atwood LD, Borecki IB, Brown MJ, Charoen P, Cucca F, Das D, de Geus EJC, Dixon AL, Döring A, Ehret G, Eyjolfsson GI, Farrall M, Forouhi NG, Friedrich N, Goessling W, Gudbjartsson DF, Harris TB, Hartikainen AL, Heath S, Hirschfield GM, Hofman A, Homuth G, Hyppönen E, Janssen HLA, Johnson T, Kangas AJ, Kema IP, Kühn JP, Lai S, Lathrop M, Lerch MM, Li Y, Liang TJ, Lin JP, Loos RJF, Martin NG, Moffatt MF, Montgomery GW, Munroe PB, Musunuru K, Nakamura Y, O'Donnell CJ, Olafsson I, Penninx BW, Pouta A, Prins BP, Prokopenko I, Puls R, Ruokonen A, Savolainen MJ, Schlessinger D, Schouten JNL, Seedorf U, Sen-Chowdhry S, Siminovitch KA, Smit JH, Spector TD, Tan W, Teslovich TM, Tukiainen T, Uitterlinden AG, van der Klauw MM, Vasan RS, Wallace C, Wallaschofski H, Wichmann HE, Willemsen G, Würtz P, Xu C, Yerges-Armstrong LM, Abecasis GR, Ahmadi KR, Boomsma DI, Caulfield M, Cookson WO, van Duijn CM, Froguel P, Matsuda K, McCarthy MI, Meisinger C, Mooser V, Pietiläinen KH, Schumann G, Snieder H, Sternberg MJE, Stolk RP, Thomas HC, Thorsteinsdottir U, Uda M, Waeber G, Wareham NJ, Waterworth DM, Watkins H, Whitfield JB, Witteman JCM, Wolffenbuttel BHR, Fox CS, Ala-Korpela M, Stefansson K, Vollenweider P, Völzke H, Schadt EE, Scott J, Järvelin MR, Elliott P, Kooner JS [Contributors: Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, Mcculloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, Mccarroll SA, Langenberg C, Hofmann OM, Dupuis J, Qi L, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Bengtsson Boström K, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Couper DJ, Crawford G, Doney ASF, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PRV, Jørgensen T, Kao WHL, Klopp N, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Perry JRB, Petersen AK, Platou C, Proença C, Prokopenko I, Rathmann W, William Rayner N, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsø T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Walters GB, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Mohlke KL, Morris AD, Palmer CNA, Pramstaller PP, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Wareham NJ, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Hu FB, Meigs JB, Pankow JS, Pedersen O, Wichmann HE, Barroso I, Florez JC, Frayling TM, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI, Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, Ferreira T, Wood AR, Weyant RJ, Segrè AV, Speliotes EK, Wheeler E, Soranzo N, Park JH, Yang J, Gudbjartsson D, Heard-Costa NL, Randall JC, Qi L, Smith AV, Mägi R, Pastinen T, Liang L, Heid IM, Luan J, Thorleifsson G, Winkler TW, Goddard ME, Sin Lo K, Palmer C, Workalemahu T, Aulchenko YS, Johansson A, Zillikens MC, Feitosa MF, Esko T, Johnson T, Ketkar S, Kraft P, Mangino M, Prokopenko I, Absher D, Albrecht E, Ernst F, Glazer NL, Hayward C, Hottenga JJ, Jacobs KB, Knowles JW, Kutalik Z, Monda KL, Polasek O, Preuss M, Rayner NW, Robertson NR, Steinthorsdottir V, Tyrer JP, Voight BF, Wiklund F, Xu J, Zhao JH, Nyholt DR, Pellikka N, Perola M, Perry JR, Surakka I, Tammesoo ML, Altmaier EL, Amin N, Aspelund T, Bhangale T, Boucher G, Chasman DI, Chen C, Coin L, Cooper MN, Dixon AL, Gibson Q, Grundberg E, Hao K, Juhani Junttila M, Kaplan LM, Kettunen J, König IR, Kwan T, Lawrence RW, Levinson DF, Lorentzon M, McKnight B, Morris AP, Müller M, Suh Ngwa J, Purcell S, Rafelt S, Salem RM, Salvi E, Sanna S, Shi J, Sovio U, Thompson JR, Turchin MC, Vandenput L, Verlaan DJ, Vitart V, White CC, Ziegler A, Almgren P, Balmforth AJ, Campbell H, Citterio L, de Grandi A, Dominiczak A, Duan J, Elliott P, Elosua R, Eriksson JG, Freimer NB, Geus EJ, Glorioso N, Haiqing S, Hartikainen AL, Havulinna AS, Hicks AA, Hui J, Igl W, Illig T, Jula A, Kajantie E, Kilpeläinen TO, Koiranen M, Kolcic I, Koskinen S, Kovacs P, Laitinen J, Liu J, Lokki ML, Marusic A, Maschio A, Meitinger T, Mulas A, Paré G, Parker AN, Peden JF, Petersmann A, Pichler I, Pietiläinen KH, Pouta A, Ridderstråle M, Rotter JI, Sambrook JG, Sanders AR, Schmidt CO, Sinisalo J, Smit JH, Stringham HM, Widen E, Wild SH, Willemsen G, Zagato L, Zgaga L, Zitting P, Alavere H, Farrall M, McArdle WL, Nelis M, Peters MJ, Ripatti S, van Meurs JB, Aben KK, Ardlie KG, Beckmann JS, Beilby JP, Bergman RN, Bergmann S, Collins FS, Cusi D, den Heijer M, Eiriksdottir G, Gejman PV, Hamsten A, Huikuri HV, Iribarren C, Kähönen M, Kaprio J, Kathiresan S, Kiemeney L, Kocher T, Launer LJ, Lehtimäki T, Melander O, Mosley TH Jr, Musk AW, Nieminen MS, O'Donnell CJ, Ohlsson C, Oostra B, Palmer LJ, Raitakari O, Ridker PM, Rioux JD, Rissanen A, Rivolta C, Schunkert H, Shuldiner AR, Siscovick DS, Stumvoll M, Tönjes A, Tuomilehto J, van Ommen GJ, Viikari J, Heath AC, Martin NG, Montgomery GW, Province MA, Kayser M, Arnold AM, Atwood LD, Boerwinkle E, Chanock SJ, Deloukas P, Gieger C, Grönberg H, Hall P, Hattersley AT, Hengstenberg C, Hoffman W, Lathrop GM, Salomaa V, Schreiber S, Uda M, Waterworth D, Wright AF, Assimes TL, Barroso I, Hofman A, Mohlke KL, Boomsma DI, Caulfield MJ, Cupples LA, Erdmann J, Fox CS, Gudnason V, Gyllensten U, Harris TB, Hayes RB, Jarvelin MR, Mooser V, Munroe PB, Ouwehand WH, Penninx BW, Pramstaller PP, Quertermous T, Rudan I, Samani NJ, Spector TD, Völzke H, Watkins H, Wilson JF, Groop LC, Haritunians T, Hu FB, Kaplan RC, Metspalu A, North KE, Schlessinger D, Wareham NJ, Hunter DJ, O'Connell JR, Strachan DP, Wichmann HE, Borecki IB, van Duijn CM, Schadt EE, Thorsteinsdottir U, Peltonen L, Uitterlinden AG, Visscher PM, Chatterjee N, Loos RJ, Boehnke M, McCarthy MI, Ingelsson E, Lindgren CM, Abecasis GR, Stefansson K, Frayling TM, Hirschhorn JN, Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Johansen CT, Fouchier SW, Isaacs A, Peloso GM, Barbalic M, Ricketts SL, Bis JC, Chambers J, Orho-Melander M, Li X, Guo X, Li M, Cho YS, Go MJ, Kim YJ, Lee JY, Park T, Kim K, Sim X, Ong RTH, Croteau-Chonka DC, Lange LA, Smith JD, Song K, Yuan X, Lamina C, Zhang W, Zee RY, Witteman JC, Whitfield JB, Waterworth DM, Waeber G, Vollenweider P, Tanaka T, Silander K, Sijbrands EJ, Scuteri A, Scott J, Salomaa J, Sabatti C, Ruokonen A, Rose LM, Roberts R, Rieder M, Psaty BM, Pedersen NL, Pattaro C, Pare G, Oostra BA, Nickerson DA, McPherson R, McArdle W, Masson D, Marroni F, Magnusson PK, Lucas G, Luben R, Langenberg C, Lakatta EG, Laaksonen R, Kyvik KO, Kronenberg F, Khaw KT, Janssens AC, Hovingh GK, Hastie ND, Hall AS, Guiducci C, Gonzalez E, Gieger NB, Ferrucci L, Ejebe KG, Döring A, Dominiczak AF, Demissie S, de Geus EJ, de Faire U, Crawford G, Chen YD, Burtt NP, Bonnycastle LL, Boekholdt SM, Bandinelli S, Ballantyne CM, Ballantyne TL, Altshuler D, Seielstad M, Wong TY, Tai ES, Feranil AB, Kuzawa CW, Adair LS, Taylor HA Jr, Gabriel SB, Wilson JG, Holm H, Krauss RM, Ordovas JM, Kooner JS, Tall AR, Hegele RA, Kastelein JJ, Reilly MP, Cupples LA, Sandhu MS, Rader DJ, Speliotes EK, Yerges-Armstrong LM, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, Nalls MA, Clark JM, Mitchell BD, Shuldiner AR, Butler JL, Tomas M, Hoffmann U, Hwang SJ, Massaro JM, O'Donnell CJ, Sahani DV, Salomaa V, Schadt EE, Schwartz SM, Siscovick DS, Carr JJ, Feitosa MF, Harris TB, Smith AV, Kao WHL, Hirschhorn JN, Borecki IB, Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Tobin MD, Verwoert GC, Pihur V, Vollenweider P, O'Reilly PF, Bragg-Gresham JL, Teumer A, Glazer NL, Launer L, Zhao JH, Aulchenko Y, Heath S, Sober S, Parsa A, Luan Ja, Arora P, Dehghan A, Zhang F, Lucas G, Hicks AA, Peden JF, Tanaka T, Wild SH, Igl W, Milaneschi Y, Parker AN, Fava C, Chambers JC, Fox ER, Kumari M, Go MJ, van der Harst P, Kao WHL, Sjogren M, Vinay DG, Alexander M, Tabara Y, Shaw-Hawkins S, Whincup PH, Liu Y, Shi G, Tayo B, Seielstad M, Sim X, Nguyen KDH, Lehtimaki T, Matullo G, Wu Y, Gaunt TR, Onland-Moret NC, Cooper MN, Platou CGP, Org E, Hardy R, Dahgam S, Palmen J, Vitart V, Braund PS, Kuznetsova T, Uiterwaal CSPM, Adeyemo A, Palmas W, Ludwig B, Tomaszewski M, Tzoulaki I, Palmer ND, Aspelund T, Garcia M, Chang YPC, O'Connell JR, Steinle NI, Grobbee DE, Arking DE, Kardia SL, Morrison AC, Hernandez D, Najjar S, McArdle WL, Hadley D, Brown MJ, Connell JM, Hingorani AD, Day INM, Lawlor DA, Beilby JP, Lawrence RW, Clarke R, Collins R, Hopewell JC, Ongen H, Dreisbach AW, Li Y, Young JH, Bis JC, Kahonen M, Viikari J, Adair LS, Lee NR, Chen MH, Olden M, Pattaro C, Bolton JAH, Kottgen A, Bergmann S, Mooser V, Chaturvedi NR, Islam M, Jafar TH, Erdmann J, Kulkarni SR, Bornstein SR, Grassler J, Kettunen J, Howard P, Taylor A, Guarrera S, Ricceri F, Emilsson V, Plump A, Barroso I, Khaw KT, Weder AB, Hunt SC, Sun YV, Peltonen L, Perola M, Vartiainen E, Brand SM, Staessen JA, Wang TJ, Burton PR, Artigas MS, Dong Y, Snieder H, Wang X, Zhu H, Lohman KK, Rudock ME, Heckbert SR, Smith NL, Wiggins KL, Doumatey A, Shriner D, Veldre G, Viigimaa M, Kinra S, Prabhakaran D, Tripathy V, Langefeld CD, Rosengren A, Thelle DS, Corsi AM, Singleton A, Forrester T, Hilton G, McKenzie CA, Salako T, Iwai N, Kita Y, Ogihara T, Ohkubo T, Okamura T, Ueshima H, Umemura S, Eyheramendy S, Cho YS, Kim HL, Lee JY, Scott J, Sehmi JS, Zhang W, Hedblad B, Smith GD, Wong A, Stančakova A, Raffel LJ, Yao J, Kathiresan S, O'Donnell C, Schwartz SM, Ikram MA, Longstreth WT Jr, Mosley TH, Seshadri S, Shrine NRG, Wain LV, Laitinen J, Zitting P, Cooper JA, Humphries SE, Danesh J, Rasheed A, Goel A, Hamsten A, Watkins H, Bakker SJL, van Gilst WH, Janipalli CS, Mani KR, Yajnik CS, Mattace-Raso FUS, Oostra BA, Demirkan A, Isaacs A, Rivadeneira F, Lakatta EG, Orru M, Scuteri A, Ala-Korpela M, Kangas AJ, Lyytikainen LP, Soininen P, Tukiainen T, Wurz P, Ong RTH, Dorr M, Kroemer HK, Volker U, Volzke H, Galan P, Hercberg S, Lathrop M, Zelenika D, Deloukas P, Mangino M, Spector TD, Zhai G, Meschia JF, Sharma P, Terzic J, Kumar MJK, Denniff M, Zukowska-Szczechowska E, Wagenknecht LE, Fowkes FGR, Charchar FJ, Schwarz PEH, Hayward C, Guo X, Rotimi C, Bots ML, Brand E, Samani NJ, Polasek O, Talmud PJ, Nyberg F, Kuh D, Laan M, Palmer LJ, van der Schouw YT, Casas JP, Vineis P, Raitakari O, Ganesh SK, Wong TY, Tai ES, Cooper RS, Rao DC, Morris RW, Dominiczak AF, Kivimaki M, Marmot MG, Miki T, Saleheen D, Chandak GR, Coresh J, Navis G, Han BG, Zhu X, Kooner JS, Melander O, Ridker PM, Bandinelli S, Gyllensten UB, Wright AF, Ferrucci L, Farrall M, Elosua R, Soranzo N, Sijbrands EJG, Loos RJF, Meneton P, Uitterlinden AG, Rotter JI, Rettig R, Uda M, Strachan DP, Witteman JCM, Hartikainen AL, Beckmann JS, Vasan RS, Larson MG, Jarvelin MR, Psaty BM, Chakravarti A, Elliott P, Newton-Cheh C, Levy D, Caulfield MJ, Johnson T, Dupuis J, Saxena R, Bouatia-Naji N, Gloyn AL, Randall J, Rybin D, Henneman P, Grallert H, Dehghan A, Franklin CS, Navarro P, Goel A, Egan JM, Lajunen T, Grarup N, Sparsø T, Doney A, Kanoni S, Shrader P, Cavalcanti-Proença C, Kumari M, Timpson NJ, Zabena C, Rocheleau G, An P, O'Connell J, Elliott A, McCarroll SA, Payne F, Roccasecca RM, Pattou F, Sethupathy P, Ardlie K, Ariyurek Y, Balkau B, Barter P, Ben-Shlomo Y, Benediktsson R, Bennett AJ, Bochud M, Bonnefond A, Borch-Johnsen K, Böttcher Y, Brunner E, Bumpstead SJ, Charpentier G, Chines P, Clarke R, Coin LJ, Cornelis M, Crisponi L, Day IN, Delplanque J, Dina C, Erdos MR, Fedson AC, Fischer-Rosinsky A, Forouhi NG, Frants R, Franzosi MG, Galan P, Goodarzi MO, Graessler J, Groves CJ, Grundy S, Gwilliam R, Hadjadj S, Hallmans G, Hammond N, Han X, Hassanali N, Heath SC, Hercberg S, Herder C, Hillman DR, Hingorani AD, Hung J, Isomaa B, Johnson PR, Jørgensen T, Kaakinen M, Kesaniemi YA, Kivimaki M, Knight B, Lathrop GM, Lawlor DA, Le Bacquer O, Lecoeur C, Li Y, Lyssenko V, Mahley R, Manning AK, Martínez-Larrad MT, McAteer JB, McCulloch LJ, Meisinger C, Melzer D, Meyre D, Mitchell BD, Morken MA, Mukherjee S, Naitza S, Narisu N, Neville MJ, Orrù M, Pakyz R, Palmer CN, Paolisso G, Pearson D, Pfeiffer AF, Posthuma D, Potter SC, Rathmann W, Rice K, Roden M, Rolandsson O, Sandbaek A, Sandhu M, Sayer AA, Scheet P, Scott LJ, Seedorf U, Sharp SJ, Shields B, Sigurethsson G, Silveira A, Simpson L, Singleton A, Smith NL, Swift A, Syddall H, Syvänen AC, Thorand B, Tichet J, Tuomi T, van Dijk KW, van Hoek M, Varma D, Visvikis-Siest S, Vogelzangs N, Wagner PJ, Walley A, Walters GB, Ward KL, Yarnell JW, Zeggini E, Zelenika D, Zethelius B, Zhai G, Zhao JH, Meneton P, Nathan DM, Williams GH, Smith GD, Bornstein SR, Schwarz P, Spranger J, Karpe F, Cooper C, Dedoussis GV, Serrano-Ríos M, Morris AD, Lind L, Franks PW, Ebrahim S, Marmot M, Kao WH, Pankow JS, Sampson MJ, Kuusisto J, Laakso M, Hansen T, Pedersen O, Buchanan TA, Valle TT, Kong A, Cao A, Sladek R, Froguel P, Watanabe RM, Meigs JB, Groop L, Florez JC]] , Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. NAT GENET 2011;43 (11):1131-U129 [PubMed]
Côté M, Cartier A, Reuwer AQ, Arsenault BJ, Lemieux I, Després JP, Wareham NJ, Kastelein JJP, Boekholdt SM, Khaw KT, Adiponectin and risk of coronary heart disease in apparently healthy men and women (from the EPIC-Norfolk Prospective Population Study). AM J CARDIOL 2011;108 (3):367-373 [PubMed]
Dogan S, Kastelein JJP, Grobbee DE, Bots ML, Mean common or mean maximum carotid intima-media thickness as primary outcome in lipid-modifying intervention studies. J ATHEROSCLER THROMB 2011;18 (11):946-957 [PubMed]
Duivenvoorden R, Holleboom AG, van den Bogaard B, Nederveen AJ, de Groot E, Hutten BA, Schimmel AW, Hovingh GK, Kastelein JJP, Kuivenhoven JA, Stroes ESG, Cholesterol Acyltransferase Gene Mutations Have Accelerated Atherogenesis as Assessed by Carotid 3.0-T Magnetic Resonance Imaging Carriers of Lecithin. J AM COLL CARDIOL 2011;58 (24):2481-2487 [PubMed]
Franssen R, Monajemi H, Stroes ESG, Kastelein JJP, Obesity and dyslipidemia. MED CLIN N AM 2011;95 (5):893-902 [PubMed]
Holleboom AG. Genetic disorders of HDL metabolism: from model to mechanism. s.l.: s.n.; 2011. 422p. ISBN 9789461081735 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Stroes ESG, Kastelein JJP; copromotor(s): Kuivenhoven JA, Hovingh GK)
Holleboom AG, Karlsson H, Lin RS, Beres TM, Sierts JA, Herman DS, Stroes ESG, Aerts JM, Kastelein JJP, Motazacker MM, Dallinga-Thie GM, Levels JHM, Zwinderman AH, Seidman JG, Seidman CE, Ljunggren S, Lefeber DJ, Morava E, Wevers RA, Fritz TA, Tabak LA, Lindahl M, Hovingh GK, Kuivenhoven JA, Heterozygosity for a loss-of-function mutation in GALNT2 improves plasma triglyceride clearance in man. CELL METAB 2011;14 (6):811-818 [PubMed]
Holleboom AG, Kuivenhoven JA, Peelman F, Schimmel AW, Peter J, Defesche JC, Kastelein JJP, Hovingh GK, Stroes ES, Motazacker MM, High prevalence of mutations in LCAT in patients with low HDL cholesterol levels in The Netherlands: identification and characterization of eight novel mutations. HUM MUTAT 2011;32 (11):1290-1298 [PubMed]
Holleboom AG, Kuivenhoven JA, van Olden CC, Peter J, Schimmel AW, Levels JH, Valentijn RM, Vos P, Defesche JC, Kastelein JJP, Hovingh GK, Stroes ESG, Hollak CEM, Proteinuria in early childhood due to familial LCAT deficiency caused by loss of a disulfide bond in lecithin:cholesterol acyl transferase. ATHEROSCLEROSIS 2011;216 (1):161-165 [PubMed]
Huijgen R, Kastelein JJP, Meijers JCM, Increased coagulation factor VIII activity in patients with familial hypercholesterolemia. BLOOD 2011;118 (26):6990-6991 [PubMed]
Huijgen R, Vissers MN, Kindt I, Trip MD, de Groot E, Kastelein JJP, Hutten BA, Assessment of carotid atherosclerosis in normocholesterolemic individuals with proven mutations in the low-density lipoprotein receptor or apolipoprotein B genes. CIRC-CARDIOVASC GENE 2011;4 (4):413-417 [PubMed]
Kastelein JJP, Duivenvoorden R, Deanfield J, de Groot E, Jukema JW, Kaski JC, Münzel T, Taddei S, Lehnert V, Burgess T, Kallend D, Lüscher TF, Rationale and design of dal-VESSEL: a study to assess the safety and efficacy of dalcetrapib on endothelial function using brachial artery flow-mediated vasodilatation. CURR MED RES OPIN 2011;27 (1):141-150 [PubMed]
Kusters DM, Huijgen R, Defesche JC, Vissers MN, Kindt I, Hutten BA, Kastelein JJP, Founder mutations in the Netherlands: geographical distribution of the most prevalent mutations in the low-density lipoprotein receptor and apolipoprotein B genes. NETH HEART J 2011;19 (4):175-182 [PubMed]
Nicholls SJ, Brewer HB, Kastelein JJP, Krueger KA, Wang MD, Shao M, Hu B, McErlean E, Nissen SE, Effects of the CETP inhibitor evacetrapib administered as monotherapy or in combination with statins on HDL and LDL cholesterol: a randomized controlled trial. JAMA-J AM MED ASSOC 2011;306 (19):2099-2109 [PubMed]
Nicholls SJ, Gordon A, Johansson J, Wolski K, Ballantyne CM, Kastelein JJP, Taylor A, Borgman M, Nissen SE, Efficacy and Safety of a Novel Oral Inducer of Apolipoprotein A-I Synthesis in Statin-Treated Patients With Stable Coronary Artery Disease A Randomized Controlled Trial. J AM COLL CARDIOL 2011;57 (9):1111-1119 [PubMed]
Nolting PRWdS, Kusters DM, Hutten BA, Kastelein JJP, Serum bilirubin levels in familial hypercholesterolemia: a new risk marker for cardiovascular disease?. J LIPID RES 2011;52 (9):1755-1759 [PubMed]
O'Leary DH, Reuwer AQ, Nissen SE, Després JP, Deanfield JE, Brown MW, Zhou R, Zabbatino SM, Job B, Kastelein JJP, Visseren FLJ [Contributors: O'Leary D, Nissen S, Cannon C, Deanfield J, Després JP, Job B, Kastelein J, Akhras R, Breger L, Dufour R, Frohlich J, Garrel D, Habib R, Leiter L, Pliamm L, Sohal P, Whitsitt P, Cottin Y, Bonnet J, Farnier M, Simon A, Trip M, Kose V, Tiebesl J, Agous I, Wiersma-Maximova A, de Schipper L, Timmerman R, Visseren F, Bak A, Basart D, Ros E, Salas J, Civeira F, Formiguera X, Mesa J, Pintó X, McCollum C, Durrington P, Betteridge J, Chowdhury T, Kopelman P, Davidson M, Sugimoto D, Kerzner B, Mersey J, Hirsch A, Lunde N, Zavoral J, Kereiakes D, Noss MJ, Roth E, Suresh DP, Ballantyne C, Garber A, Pool J, Brinton E, Kirstein J, Lubin B, Harris L, Hoekstra J, Call R, Brazg R, Larson W, Scherbarth K, Stonesifer L, Stein J, Bittar N]] , Effect of rimonabant on carotid intima-media thickness (CIMT) progression in patients with abdominal obesity and metabolic syndrome: the AUDITOR Trial. HEART 2011;97 (14):1143-1150 [PubMed]
Olsson AG, Lindahl C, Holme I, Fayyad R, Faergeman O, Kastelein JJP, Tikkanen MJ, Larsen ML, Pedersen TR, LDL cholesterol goals and cardiovascular risk during statin treatment: the IDEAL study. EUR J CARDIOV PREV R 2011;18 (2):262-269 [PubMed]
Preiss D, Seshasai SRK, Welsh P, Murphy SA, Ho JE, Waters DD, Demicco DA, Barter P, Cannon CP, Sabatine MS, Braunwald E, Kastelein JJP, de Lemos JA, Blazing MA, Pedersen TR, Tikkanen MJ, Sattar N, Ray KK, Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy A Meta-analysis. JAMA-J AM MED ASSOC 2011;305 (24):2556-2564 [PubMed]
Rana JS, Arsenault BJ, Després JP, Côté M, Talmud PJ, Ninio E, Wouter Jukema J, Wareham NJ, Kastelein JJP, Khaw KT, Boekholdt SM, Inflammatory biomarkers, physical activity, waist circumference, and risk of future coronary heart disease in healthy men and women. EUR HEART J 2011;32 (3):336-344 [PubMed]
Ravandi A, Boekholdt SM, Mallat Z, Talmud PJ, Kastelein JJP, Wareham NJ, Miller ER, Benessiano J, Tedgui A, Witztum JL, Khaw KT, Tsimikas S, Relationship of IgG and IgM autoantibodies and immune complexes to oxidized LDL with markers of oxidation and inflammation and cardiovascular events: results from the EPIC-Norfolk Study. J LIPID RES 2011;52 (10):1829-1836 [PubMed]
Regieli JJ, Doevendans PA, Grobbee DE, Zwinderman AH, van der Graaf Y, Kastelein JJP, Jukema JW, ABCA1 impacts athero-thrombotic risk and 10-year survival in a contemporary secondary prevention setting. ATHEROSCLEROSIS 2011;218 (2):457-463 [PubMed]
Rensing KL, Reuwer AQ, Arsenault BJ, von der Thüsen JH, Hoekstra JBL, Kastelein JJP, Twickler TB, Reducing cardiovascular disease risk in patients with type 2 diabetes and concomitant macrovascular disease: can insulin be too much of a good thing?. DIABETES OBES METAB 2011;13 (12):1073-1087 [PubMed]
Reuwer AQ. Prolactin and vascular diseas; a first cautious assessment. s.l.: s.n.; 2011. 223p. ISBN 9789088913136 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Twickler TB, Goffin V)
Reuwer A, van Eijk M, Houttuijn-Bloemendaal F, van der Loos C, Claessen N, Teeling P, Kastelein JJ, Hamann J, Goffin V, von der Thüsen J, Twickler M, Aten J, The prolactin receptor is expressed in macrophages within human carotid atherosclerotic plaques: a role for prolactin in atherogenesis?. J ENDOCRINOL 2011;208 (2):107-117 [PubMed]
Ridker PM, Koenig W, Kastelein JJP, C-reactive protein in the Heart Protection Study. LANCET 2011;377 (9781):1918-1918; author reply 1919 [PubMed]
Ryu SK, Hutten BA, Vissers MN, Wiegman A, Kastelein JJP, Tsimikas S, Lipoprotein-associated phospholipase A(2) mass and activity in children with heterozygous familial hypercholesterolemia and unaffected siblings: Effect of pravastatin. J CLIN LIPIDOL 2011;5 (1):50-56 [PubMed]
Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AFR, Barbalic M, Gieger C, Absher D, Aherrahrou Z, Allayee H, Altshuler D, Anand SS, Andersen K, Anderson JL, Ardissino D, Ball SG, Balmforth AJ, Barnes TA, Becker DM, Becker LC, Berger K, Bis JC, Boekholdt SM, Boerwinkle E, Braund PS, Brown MJ, Burnett MS, Buysschaert I, Carlquist JF, Chen L, Cichon S, Codd V, Davies RW, Dedoussis G, Dehghan A, Demissie S, Devaney JM, Diemert P, Do R, Doering A, Eifert S, Mokhtari NEE, Ellis SG, Elosua R, Engert JC, Epstein SE, de Faire U, Fischer M, Folsom AR, Freyer J, Gigante B, Girelli D, Gretarsdottir S, Gudnason V, Gulcher JR, Halperin E, Hammond N, Hazen SL, Hofman A, Horne BD, Illig T, Iribarren C, Jones GT, Jukema JW, Kaiser MA, Kaplan LM, Kastelein JJP, Khaw KT, Knowles JW, Kolovou G, Kong A, Laaksonen R, Lambrechts D, Leander K, Lettre G, Li M, Lieb W, Loley C, Lotery AJ, Mannucci PM, Maouche S, Martinelli N, McKeown PP, Meisinger C, Meitinger T, Melander O, Merlini PA, Mooser V, Morgan T, Mühleisen TW, Muhlestein JB, Münzel T, Musunuru K, Nahrstaedt J, Nelson CP, Nöthen MM, Olivieri O, Patel RS, Patterson CC, Peters A, Peyvandi F, Qu L, Quyyumi AA, Rader DJ, Rallidis LS, Rice C, Rosendaal FR, Rubin D, Salomaa V, Sampietro ML, Sandhu MS, Schadt E, Schäfer A, Schillert A, Schreiber S, Schrezenmeir J, Schwartz SM, Siscovick DS, Sivananthan M, Sivapalaratnam S, Smith A, Smith TB, Snoep JD, Soranzo N, Spertus JA, Stark K, Stirrups K, Stoll M, Tang WHW, Tennstedt S, Thorgeirsson G, Thorleifsson G, Tomaszewski M, Uitterlinden AG, van Rij AM, Voight BF, Wareham NJ, Wells GA, Wichmann HE, Wild PS, Willenborg C, Witteman JCM, Wright BJ, Ye S, Zeller T, Ziegler A, Cambien F, Goodall AH, Cupples LA, Quertermous T, März W, Hengstenberg C, Blankenberg S, Ouwehand WH, Hall AS, Deloukas P, Thompson JR, Stefansson K, Roberts R, Thorsteinsdottir U, O'Donnell CJ, McPherson R, Erdmann J, Samani NJ, Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. NAT GENET 2011;43 (4):333-U153 [PubMed]
Sivapalaratnam S, Motazacker MM, Maiwald S, Hovingh GK, Kastelein JJP, Levi M, Trip MD, Dallinga-Thie GM, Genome-wide association studies in atherosclerosis. CURR ATHEROSCLER REP 2011;13 (3):225-232 [PubMed]
Sjouke B, Kusters DM, Kastelein JJP, Hovingh GK, Familial hypercholesterolemia: present and future management. CURR CARDIOL REP 2011;13 (6):527-536 [PubMed]
Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME, Bouatia-Naji N, Dimas AS, Nica A, Wheeler E, Chen H, Voight BF, Taneera J, Kanoni S, Peden JF, Turrini F, Gustafsson S, Zabena C, Almgren P, Barker DJP, Barnes D, Dennison EM, Eriksson JG, Eriksson P, Eury E, Folkersen L, Fox CS, Frayling TM, Goel A, Gu HF, Horikoshi M, Isomaa B, Jackson AU, Jameson KA, Kajantie E, Kerr-Conte J, Kuulasmaa T, Kuusisto J, Loos RJF, Luan Ja, Makrilakis K, Manning AK, Martínez-Larrad MT, Narisu N, Nastase Mannila M, Ohrvik J, Osmond C, Pascoe L, Payne F, Sayer AA, Sennblad B, Silveira A, Stancáková A, Stirrups K, Swift AJ, Syvänen AC, Tuomi T, van 't Hooft FM, Walker M, Weedon MN, Xie W, Zethelius B, Ongen H, Mälarstig A, Hopewell JC, Saleheen D, Chambers J, Parish S, Danesh J, Kooner J, Ostenson CG, Lind L, Cooper CC, Serrano-Ríos M, Ferrannini E, Forsen TJ, Clarke R, Franzosi MG, Seedorf U, Watkins H, Froguel P, Johnson P, Deloukas P, Collins FS, Laakso M, Dermitzakis ET, Boehnke M, McCarthy MI, Wareham NJ, Groop L, Pattou F, Gloyn AL, Dedoussis GV, Lyssenko V, Meigs JB, Barroso I, Watanabe RM, Ingelsson E, Langenberg C, Hamsten A, Florez JC [Contributors: Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, Mcculloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, Mccarroll SA, Langenberg C, Hofmann OM, Qi L, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Bengtsson Boström K, Bravenboer B, Bumpstead S, Burtt P, Charpentier G, Chines PS, Cornelis M, Couper DJ, Crawford G, Doney ASF, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PRV, Jørgensen T, Kao WHL, Klopp N, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Perry JRB, Petersen K, Platou C, Proença C, Prokopenko I, Rathmann W, William Rayner N, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsø T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet JV, Bragi Walters G, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Mohlke KL, Morris AD, Palmer CNA, Pramstaller PP, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Wareham NJ, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Hu FB, Meigs JB, Pankow JS, Pedersen O, Wichmann E, Barroso I, Florez JC, Frayling TM, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, Stefansson K, Altshuler D, Boehnke M, McCarthy MI, Speliotes EK, Berndt SI, Monda KL, Allen HL, Luan Ja, Mägi R, Randall JC, Vedantam S, Winkler TW, Workalemahu T, Heid IM, Wheeler E, Wood AR, Weyant RJ, Estrada K, Liang L, Nemesh J, Park JH, Gustafsson S, Kilpeläinen TO, Yang J, Bouatia-Naji N, Esko T, Feitosa MF, Kutalik Z, Mangino M, Scherag A, Smith AV, Welch R, Zhao JH, Aben KK, Absher DM, Dixon AL, Fisher E, Glazer NL, Goddard ME, Heard-Costa NL, Hoesel V, Hottenga JJ, Johansson Å, Johnson T, Ketkar S, Lamina C, Li S, Moffatt MF, Myers RH, Peters MJ, Preuss M, Ripatti S, Rivadeneira F, Sandholt C, Timpson NJ, Tyrer JP, van Wingerden S, White CC, Wiklund F, Barlassina C, Chasman DI, Cooper MN, Jansson JO, Lawrence RW, Pellikka N, Shi J, Thiering E, Alavere H, Alibrandi MTS, Almgren P, Arnold AM, Aspelund T, Atwood LD, Balmforth AJ, Ben-Shlomo Y, Bergmann S, Biebermann H, Blakemore AIF, Boes T, Bornstein SR, Brown MJ, Buchanan TA, Busonero F, Cappuccio FP, Cavalcanti-Proença C, Ida Chen YD, Chen CM, Clarke R, Coin L, Connell J, Day INM, den Heijer M, Duan J, Ebrahim S, Elliott P, Elosua R, Eiriksdottir G, Eriksson JG, Facheris MF, Felix SB, Fischer-Posovszky P, Folsom AR, Friedrich N, Freimer NB, Fu M, Gaget S, Gejman PV, Geus EJC, Gjesing AP, Goel A, Goyette P, Grässler J, Greenawalt DM, Gudnason V, Hartikainen AL, Hall AS, Havulinna AS, Hayward C, Heath AC, Hengstenberg C, Hicks AA, Hinney A, Homuth G, Hui J, Igl W, Iribarren C, Jacobs KB, Jarick I, Jewell E, John U, Jousilahti P, Jula A, Kaakinen M, Kajantie E, Kaplan LM, Kathiresan S, Kettunen J, Kinnunen L, Knowles JW, Kolcic I, König IR, Koskinen S, Kovacs P, Kvaløy K, Laitinen J, Lantieri O, Lanzani C, Launer LJ, Lecoeur C, Terho L, Lettre G, Liu J, Lokki ML, Lorentzon M, Luben RN, Ludwig B, Manunta P, Marek D, Martin NG, McArdle WL, McCarthy A, McKnight B, Melander O, Meyre D, Montgomery GW, Mulic R, Ngwa JS, Nelis M, Neville MJ, Nyholt DR, O'Donnell CJ, O'Rahilly S, Ong KK, Oostra B, Paré G, Parker AN, Perola M, Pichler I, Pietiläinen KH, Platou CGP, Polasek O, Pouta A, Rafelt S, Raitakari O, Rayner NW, Ridderstråle M, Rief W, Ruokonen A, Rzehak P, Salomaa V, Sanders AR, Sandhu MS, Sanna S, Saramies J, Savolainen MJ, Scherag S, Schipf S, Schreiber S, Schunkert H, Silander K, Sinisalo J, Siscovick DS, Smit JH, Soranzo N, Sovio U, Stephens J, Surakka I, Tammesoo ML, Tardif JC, Teder-Laving M, Teslovich TM, Thompson JR, Thomson B, Tönjes A, van Meurs JBJ, van Ommen GJ, Vatin V, Viikari J, Visvikis-Siest S, Vitart V, Vogel CIG, Waite LL, Wallaschofski H, Walters GB, Widen E, Wiegand S, Wild SH, Willemsen G, Witte DR, Witteman JC, Xu J, Zhang Q, Zgaga L, Ziegler A, Zitting P, Beilby JP, Farooqi IS, Hebebrand J, Huikuri HV, James AL, Kähönen M, Levinson DF, Macciardi F, Nieminen MS, Ohlsson C, Palmer LJ, Ridker PM, Stumvoll M, Beckmann JS, Boeing H, Dorret I B, Caulfield MJ, Chanock SJ, Cupples LA, Smith GD, Erdmann J, Grönberg H, Hall P, Harris TB, Hayes RB, Heinrich J, Jarvelin MR, Kaprio J, Karpe F, Khaw KT, Kiemeney LA, Krude H, Lawlor DA, Metspalu A, Munroe PB, Ouwehand WH, Penninx BW, Peters A, Quertermous T, Reinehr T, Rissanen A, Samani NJ, Schwarz PEH, Shuldiner AR, Spector TD, Uda M, Uitterlinden A, Valle TT, Wabitsch M, Waeber G, Watkins H, McCarroll SA, Shaun P, Eric E S, Peter M V, Assimes TL, Borecki IB, Deloukas P, Groop LC, Haritunians T, Kaplan RC, O'Connell JR, Peltonen L, Schlessinger D, Strachan DP, van Duijn CM, Barroso H, North KE, Hirschhorn JN, Ingelsson E, Loos RJF, Nica AC, Parts L, Glass D, Nisbet J, Barrett A, Sekowska M, Travers M, Potter S, Grundberg E, Small K, Hedman ÅK, Bataille V, Bell JT, Surdulescu G, Dimas AS, Ingle C, Nestle FO, di Meglio P, Min JL, Wilk A, Hammond CJ, Yang TP, Montgomery SB, O'Rahilly S, Zondervan KT, Durbin R, Ahmadi K, Dermitzakis ET, Reilly MP, Holm H, Stewart AFR, Barbalic M, Absher D, Aherrahrou Z, Allayee H, Anand SS, Andersen K, Anderson JL, Ardissino D, Ball SG, Barnes TA, Becker DM, Becker LC, Berger K, Bis JC, Boekholdt SM, Braund PS, Burnett MS, Buysschaert I, Carlquist JF, Chen L, Cichon S, Codd V, Davies RW, Dedoussis G, Dehghan A, Demissie S, Devaney JM, Diemert P, Do R, Doering A, Eifert S, El Mokhtari NE, Ellis SG, Engert JC, Epstein SE, de Faire U, Fischer M, Freyer J, Gigante B, Girelli D, Gretarsdottir S, Gulcher JR, Halperin E, Hammond N, Hazen SL, Horne BD, Jones GT, Jukema JW, Kaiser MA, Kastelein JJP, Khaw KT, Kolovou G, Laaksonen R, Lambrechts D, Leander K, Li M, Lieb W, Loley C, Lotery AJ, Mannucci PM, Maouche S, Martinelli N, McKeown PP, Meisinger C, Merlini PA, Mooser V, Morgan T, Mühleisen TW, Muhlestein JB, Münzel T, Musunuru K, Nahrstaedt J, Nelson CP, Nöthen MM, Olivieri O, Patel RS, Patterson CC, Peyvandi F, Qu L, Quyyumi AA, Rader DJ, Rallidis LS, Rice C, Rosendaal FR, Rubin D, Sampietro ML, Sandhu MS, Schadt E, Schäfer A, Schillert A, Schrezenmeir J, Schwartz SM, Sivananthan M, Sivapalaratnam S, Smith A, Smith TB, Snoep JD, Spertus JA, Stark K, Stirrups K, Stoll M, Tang WHW, Tennstedt S, Thorgeirsson G, Tomaszewski M, Uitterlinden AG, van Rij AM, Wareham NJ, Wells GA, Wichmann HE, Wild PS, Willenborg C, Witteman JCM, Wright BJ, Ye S, Zeller T, Cambien F, Goodall AH, März W, Blankenberg S, Roberts R, McPherson R, Nilesh J S]] , Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. DIABETES 2011;60 (10):2624-2634 [PubMed]
Taylor AJ, Bots ML, Kastelein JJP, Vascular disease: Meta-regression of CIMT trials-data in, garbage out. NAT REV CARDIOL 2011;8 (3):128-130 [PubMed]
van den Bogaard B, van den Born BJH, Fayyad R, Waters DD, Demicco DA, LaRosa JC, Kastelein JJP, Holme I, On-treatment lipoprotein components and risk of cerebrovascular events in the Treating to New Targets study. EUR J CLIN INVEST 2011;41 (2):134-142 [PubMed]
van der Graaf A, Avis HJ, Kusters DM, Vissers MN, Hutten BA, Defesche JC, Huijgen R, Fouchier SW, Wijburg FA, Kastelein JJP, Wiegman A, Molecular Basis of Autosomal Dominant Hypercholesterolemia Assessment in a Large Cohort of Hypercholesterolemic Children. CIRCULATION 2011;123 (11):1167-1173 [PubMed]
Vergeer AMH. HDL genes & HDL drugs. s.l.: s.n.; 2011. 303p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Kuivenhoven JA, Stroes ESG)
Vergeer M, Korporaal SJA, Franssen R, Meurs I, Out R, Hovingh GK, Hoekstra M, Sierts JA, Dallinga-Thie GM, Motazacker MM, Holleboom AG, van Berkel TJC, Kastelein JJP, van Eck M, Kuivenhoven JA, Genetic Variant of the Scavenger Receptor BI in Humans. NEW ENGL J MED 2011;364 (2):136-145 [PubMed]
Versmissen J, Botden IPG, Huijgen R, Oosterveer DM, Defesche JC, Heil TC, Muntz A, Langendonk JG, Schinkel AFL, Kastelein JJP, Sijbrands EJG, Maternal inheritance of familial hypercholesterolemia caused by the V408M low-density lipoprotein receptor mutation increases mortality. ATHEROSCLEROSIS 2011;219 (2):690-693 [PubMed]
Versmissen J, Oosterveer DM, Hoekstra M, Out R, Berbée JFP, Blommesteijn-Touw AC, van Vark-van der Zee L, Vongpromek R, Vanmierlo T, Defesche JC, Mulder M, Kastelein JJP, Sijbrands EJG, Apolipoprotein isoform E4 does not increase coronary heart disease risk in carriers of low-density lipoprotein receptor mutations. CIRC-CARDIOVASC GENE 2011;4 (6):655-660 [PubMed]
Versmissen J, Oosterveer DM, Yazdanpanah M, Mulder M, Dehghan A, Defesche JC, Kastelein JJP, Sijbrands EJG, A frequent variant in the ABCA1 gene is associated with increased coronary heart disease risk and a better response to statin treatment in familial hypercholesterolemia patients. EUR HEART J 2011;32 (4):469-475 [PubMed]
Waters DD, Ho JE, Demicco DA, Breazna A, Arsenault BJ, Wun CC, Kastelein JJ, Colhoun H, Barter P, Predictors of New-Onset Diabetes in Patients Treated With Atorvastatin Results From 3 Large Randomized Clinical Trials. J AM COLL CARDIOL 2011;57 (14):1535-1545 [PubMed]
[Contributors: Peden JF, Hopewell JC, Saleheen D, Chambers JC, Hager J, Soranzo N, Collins R, Danesh J, Elliott P, Farrall M, Stirrups K, Zhang W, Hamsten A, Parish S, Lathrop M, Watkins H, Clarke R, Deloukas P, Kooner JS, Goel A, Ongen H, Strawbridge RJ, Heath S, Mälarstig A, Helgadottir A, Öhrvik J, Murtaza M, Potter S, Hunt SE, Delepine M, Jalilzadeh S, Axelsson T, Syvanen AC, Gwilliam R, Bumpstead S, Gray E, Edkins S, Folkersen L, Kyriakou T, Franco-Cereceda A, Gabrielsen A, Seedorf U, Eriksson P, Offer A, Bowman L, Sleight P, Armitage J, Peto R, Abecasis G, Ahmed N, Caulfield M, Donnelly P, Froguel P, Kooner AS, McCarthy MI, Samani NJ, Scott J, Sehmi J, Silveira A, Hellénius ML, van't Hooft FM, Olsson G, Rust S, Assman G, Barlera S, Tognoni G, Franzosi MG, Linksted P, Green FR, Rasheed A, Zaidi M, Shah N, Samuel M, Mallick NH, Azhar M, Zaman KS, Samad A, Ishaq M, Gardezi AR, Fazal-ur-Rehman M, Frossard PM, Spector T, Peltonen L, Nieminen MS, Sinisalo J, Salomaa V, Ripatti S, Bennett D, Leander K, Gigante B, de Faire U, Pietri S, Gori F, Marchioli R, Sivapalaratnam S, Kastelein JJP, Trip MD, Theodoraki EV, Dedoussis GV, Engert JC, Yusuf S, Anand SS]] , A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. NAT GENET 2011;43 (4):339-344 [PubMed]
[Contributors: Butterworth AS, Braund PS, Farrall M, Hardwick RJ, Saleheen D, Peden JF, Soranzo N, Chambers JC, Sivapalaratnam S, Kleber ME, Keating B, Qasim A, Klopp N, Erdmann J, Assimes TL, Ball SG, Balmforth AJ, Barnes TA, Basart H, Baumert J, Bezzina CR, Boerwinkle E, Boehm BO, Brocheton J, Bugert P, Cambien F, Clarke R, Codd V, Collins R, Couper D, Cupples LA, de Jong JS, Diemert P, Ejebe K, Elbers CC, Elliott P, Fornage M, Franzosi MG, Frossard P, Garner S, Goel A, Goodall AH, Hengstenberg C, Hunt SE, Kastelein JJP, Klungel OH, Klüter H, Koch K, König IR, Kooner AS, Laaksonen R, Lathrop M, Li M, Liu K, McPherson R, Musameh MD, Musani S, Nelson CP, O'Donnell CJ, Ongen H, Papanicolaou G, Peters A, Peters BJM, Potter S, Psaty BM, Qu L, Rader DJ, Rasheed A, Rice C, Scott J, Seedorf U, Sehmi JS, Sotoodehnia N, Stark K, Stephens J, van der Schoot CE, van der Schouw YT, Thorsteinsdottir U, Tomaszewski M, van der Harst P, Vasan RS, Wilde AAM, Willenborg C, Winkelmann BR, Zaidi M, Zhang W, Ziegler A, de Bakker PIW, Koenig W, Mätz W, Trip MD, Reilly MP, Kathiresan S, Schunkert H, Hamsten A, Hall AS, Kooner JS, Thompson SG, Thompson JR, Deloukas P, Ouwehand WH, Watkins H, Danesh J, Samani NJ, Barnes T, Rafelt S, Bruinsma N, Dekker LR, Henriques JP, Koch KT, de Winter RJ, Alings M, Allaart CF, Gorgels AP, Verheugt FW, Mueller M, Meisinger C, DerOhannessian S, Mehta NN, Ferguson J, Hakonarson H, Matthai W, Wilensky R, Hopewell JC, Parish S, Linksted P, Notman J, Gonzalez H, Young A, Ostley T, Munday A, Goodwin N, Verdon V, Shah S, Cobb L, Edwards C, Mathews C, Gunter R, Benham J, Davies C, Cobb M, Crowther J, Richards A, Silver M, Tochlin S, Mozley S, Clark S, Radley M, Kourellias K, Silveira A, Söderholm B, Olsson P, Barlera S, Tognoni G, Rust S, Assmann G, Heath S, Zelenika D, Gut I, Green F, Peden J, Aly A, Anner K, Björklund K, Blomgren G, Cederschiöld B, Danell-Toverud K, Eriksson P, Grundstedt U, Heinonen M, Hellénius ML, van't Hooft F, Husman K, Lagercrantz J, Larsson A, Larsson M, Mossfeldt M, Mälarstig A, Olsson G, Sabater-Lleal M, Sennblad B, Strawbridge R, Öhrvik J, Zaman KS, Mallick NH, Azhar M, Samad A, Ishaq M, Shah N, Samuel M, Reilly M, Holm H, Preuss M, Stewart AFR, Barbalic M, Gieger C, Absher D, Aherrahrou Z, Allayee H, Altshuler D, Anand S, Andersen K, Anderson JL, Ardissino D, Becker LC, Becker DM, Berger K, Bis JC, Boekholdt SM, Brown MJ, Burnett MS, Buysschaert I, Carlquist JF, Chen L, Davies RW, Dedoussis G, Dehghan A, Demissie S, Devaney J, Do R, Doering A, El Mokhtari NE, Ellis SG, Elosua R, Engert JC, Epstein S, de Faire U, Fischer M, Folsom AR, Freyer J, Gigante B, Girelli D, Gretarsdottir S, Gudnason V, Gulcher JR, Tennstedt S, Halperin E, Hammond N, Hazen SL, Hofman A, Horne BD, Illig T, Iribarren C, Jones GT, Jukema JW, Kaiser MA, Kaplan LM, Khaw KT, Knowles JW, Kolovou G, Kong A, Lambrechts D, Leander K, Lieb W, Lettre G, Loley C, Lotery AJ, Mannucci PM, Maouche S, Martinelli N, McKeown PP, Meitinger T, Melander O, Merlini PA, Mooser V, Morgan T, Mühleisen TW, Muhlestein JB, Musunuru K, Nahrstaedt J, Nöthen MM, Olivieri O, Peyvandi F, Patel RS, Patterson CC, Quyyumi AA, Rallidis LS, Roosendaal FR, Rubin D, Salomaa V, Sampietro ML, Sandhu MS, Schadt E, Schäfer A, Schillert A, Schreiber S, Schrezenmeir J, Schwartz SM, Siscovick DS, Sivananthan M, Smith AV, Smith TB, Snoep JD, Spertus JA, Stefansson K, Stirrups K, Stoll M, Tang WHW, Thorgeirsson G, Thorleifsson G, Uitterlinden AG, van Rij AM, Voight BF, Wareham NJ, AWells G, Wichmann HE, Witteman JCM, Wright BJ, Ye S, Quertermous T, März W, Blankenberg S, Roberts R, Onland-Moret NC, van Setten J, Verschuren WMM, Boer JMA, Wijmenga C, Hofker MH, Maitland-van der Zee AH, de Boer A, Grobbee DE, Attwood T, Belz S, Braund P, Cambien F, Cooper J, Crisp-Hihn A, Foad N, Gracey J, Gray E, Gwilliams R, Heimerl S, Jolley J, Krishnan U, Lloyd-Jones H, Lugauer I, Lundmark P, Moore JS, Muir D, Murray E, Nelson CP, Neudert J, Niblett D, O'Leary K, Pollard H, Rankin A, Rice CM, Sager H, Sambrook J, Schmitz G, Scholz M, Schroeder L, Syvannen AC, Wallace C]] , Large-scale gene-centric analysis identifies novel variants for coronary artery disease. PLOS GENET 2011;7 (9):e1002260 [PubMed]
Akdim F. LDL cholesterol lowering beyond statins. s.l.: s.n.; 2010. 166p. ISBN 9789085599555 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Stroes ESG)
Akdim F, Stroes ESG, Sijbrands EJG, Tribble DL, Trip MD, Jukema JW, Flaim JD, Su J, Yu R, Baker BF, Wedel MK, Kastelein JJP, Efficacy and Safety of Mipomersen, an Antisense Inhibitor of Apolipoprotein B, in Hypercholesterolemic Subjects Receiving Stable Statin Therapy. J AM COLL CARDIOL 2010;55 (15):1611-1618 [PubMed]
Akdim F, Visser ME, Tribble DL, Baker BF, Stroes ESG, Yu R, Flaim JD, Su J, Stein EA, Kastelein JJP, Effect of Mipomersen, an Apolipoprotein B Synthesis Inhibitor, on Low-Density Lipoprotein Cholesterol in Patients With Familial Hypercholesterolemia. AM J CARDIOL 2010;105 (10):1413-1419 [PubMed]
Arsenault BJ, Barter P, Demicco DA, Bao W, Preston GM, LaRosa JC, Grundy SM, Deedwania P, Greten H, Wenger NK, Shepherd J, Waters DD, Kastelein JJP, Prediction of Cardiovascular Events in Statin-Treated Stable Coronary Patients by Lipid and Nonlipid Biomarkers. J AM COLL CARDIOL 2010;57 (1):63-69 [PubMed]
Arsenault BJ, Després JP, Stroes ESG, Wareham NJ, Kastelein JJP, Khaw KT, Boekholdt SM, Lipid assessment, metabolic syndrome and coronary heart disease risk. EUR J CLIN INVEST 2010;40 (12):1081-1093 [PubMed]
Arsenault BJ, Lemieux I, Després JP, Wareham NJ, Kastelein JJP, Khaw KT, Boekholdt SM, The hypertriglyceridemic-waist phenotype and the risk of coronary artery disease: results from the EPIC-Norfolk Prospective Population Study. CAN MED ASSOC J 2010;182 (13):1427-1432 [PubMed]
Arsenault BJ, Lemieux I, Després JP, Wareham NJ, Stroes ESG, Kastelein JJP, Khaw KT, Boekholdt SM, Comparison between Gradient Gel Electrophoresis and Nuclear Magnetic Resonance Spectroscopy in Estimating Coronary Heart Disease Risk Associated with LDL and HDL Particle Size. CLIN CHEM 2010;56 (5):789-798 [PubMed]
Arsenault BJ, Rana JS, Lemieux I, Després JP, Kastelein JJP, Boekholdt SM, Wareham NJ, Khaw KT, Physical inactivity, abdominal obesity and risk of coronary heart disease in apparently healthy men and women. INT J OBESITY 2010;34 (2):340-347 [PubMed]
Arsenault BJ, Rana JS, Lemieux I, Després JP, Wareham NJ, Kastelein JJP, Boekholdt SM, Khaw KT, Physical activity, the Framingham risk score and risk of coronary heart disease in men and women of the EPIC-Norfolk study. ATHEROSCLEROSIS 2010;209 (1):261-265 [PubMed]
Avis HJ, Hutten BA, Gagné C, Langslet G, McCrindle BW, Wiegman A, Hsia J, Kastelein JJP, Stein EA, Efficacy and safety of rosuvastatin therapy for children with familial hypercholesterolemia. J AM COLL CARDIOL 2010;55 (11):1121-1126 [PubMed]
Avis HJ, Scheffer HJ, Kastelein JJP, Dallinga-Thie GM, Wijburg FA, Pink-creamy whole blood in a 3-month-old infant with a homozygous deletion in the lipoprotein lipase gene. CLIN GENET 2010;77 (5):430-433 [PubMed]
Bisoendial RJ, Boekholdt SM, Vergeer M, Stroes ESG, Kastelein JJP, C-reactive protein is a mediator of cardiovascular disease. EUR HEART J 2010;31 (17):2087-U1505 [PubMed]
Bisoendial RJ, Stroes ESG, Kastelein JJP, Tak PP, Targeting cardiovascular risk in rheumatoid arthritis: a dual role for statins. NAT REV RHEUMATOL 2010;6 (3):157-164 [PubMed]
Boekholdt SM, Kastelein JJ, C-reactive protein measurement and cardiovascular disease Reply. LANCET 2010;375 (9720):1077-1078
Boekholdt SM, Kastelein JJP, C-reactive protein and cardiovascular risk: more fuel to the fire. LANCET 2010;375 (9709):95-96 [PubMed]
Charakida M, Masi S, Lüscher TF, Kastelein JJP, Deanfield JE, Assessment of atherosclerosis: the role of flow-mediated dilatation. EUR HEART J 2010;31 (23):2854-U24 [PubMed]
Dallinga-Thie GM, Franssen R, Mooij HL, Visser ME, Hassing HC, Peelman F, Kastelein JJP, Péterfy M, Nieuwdorp M, The metabolism of triglyceride-rich lipoproteins revisited: New players, new insight. ATHEROSCLEROSIS 2010;211 (1):1-8 [PubMed]
Dogan S, Duivenvoorden R, Grobbee DE, Kastelein JJP, Shear CL, Evans GW, Visseren FL, Bots ML, Ultrasound protocols to measure carotid intima-media thickness in trials; comparison of reproducibility, rate of progression, and effect of intervention in subjects with familial hypercholesterolemia and subjects with mixed dyslipidemia. ANN MED 2010;42 (6):447-464 [PubMed]
Dogan S, Duivenvoorden R, Grobbee ED, Kastelein JJP, Shear CL, Evans GW, Visseren FL, Bots ML, Completeness of Carotid Intima Media Thickness Measurements Depends on Body Composition: The RADIANCE 1 and 2 trials. J ATHEROSCLER THROMB 2010;17 (5):526-535 [PubMed]
Duivenvoorden R, VanBavel E, de Groot E, Stroes ESG, Disselhorst JA, Hutten BA, Laméris JS, Kastelein JJP, Nederveen AJ, Endothelial shear stress: a critical determinant of arterial remodeling and arterial stiffness in humans--a carotid 3.0-T MRI study. CIRC-CARDIOVASC IMAG 2010;3 (5):578-585 [PubMed]
Duivenvoorden R, Vergeer M, Kastelein JJP, Niacin Compared with Ezetimibe. NEW ENGL J MED 2010;362 (11):1046-1047 [PubMed]
Franssen R. Abormalities in lipoprotein metabolism: from dysfunctionla HHDL to abnormal processing of triglyceride-rich lipoproteins. s.l.: s.n.; 2010. 272p. ISBN 9789461080929 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Stroes ESG, Dallinga-Thie GM)
Franssen R, Young SG, Peelman F, Hertecant J, Sierts JA, Schimmel AWM, Bensadoun A, Kastelein JJP, Fong L, Dallinga-Thie GM, Beigneux AP, Chylomicronemia With Low Postheparin Lipoprotein Lipase Levels in the Setting of GPIHBP1 Defects. CIRC-CARDIOVASC GENE 2010;3 (2):169-178 [PubMed]
Geenen MM, Bakker PJM, Kremer LCM, Kastelein JJP, van Leeuwen FE, Increased prevalence of risk factors for cardiovascular disease in long-term survivors of acute lymphoblastic leukemia and Wilms tumor treated with radiotherapy. PEDIATR BLOOD CANCER 2010;55 (4):690-697 [PubMed]
Holleboom AG, Kuivenhoven JA, Vergeer M, Hovingh GK, van Miert JN, Wareham NJ, Kastelein JJP, Khaw KT, Boekholdt SM, Plasma levels of lecithin:cholesterol acyltransferase and risk of future coronary artery disease in apparently healthy men and women: a prospective case-control analysis nested in the EPIC-Norfolk population study. J LIPID RES 2010;51 (2):416-421 [PubMed]
Holme I, Fayyad R, Faergeman O, Kastelein JJP, Olsson AG, Tikkanen MJ, Larsen ML, Lindahl C, Holdaas H, Pedersen TR, Cardiovascular outcomes and their relationships to lipoprotein components in patients with and without chronic kidney disease: results from the IDEAL trial. J INTERN MED 2010;267 (6):567-575 [PubMed]
Hovingh GK, Bochem AE, Kastelein JJP, Apolipoprotein A-I mimetic peptides. CURR OPIN LIPIDOL 2010;21 (6):481-486 [PubMed]
Huijgen R, Abbink EJ, Bruckert E, Stalenhoef AFH, Imholz BPM, Durrington PN, Trip MD, Eriksson M, Visseren FLJ, Schaefer JR, Kastelein JJP, Colesevelam Added to Combination Therapy With a Statin and Ezetimibe in Patients With Familial Hypercholesterolemia: A 12-Week, Multicenter, Randomized, Double-Blind, Controlled Trial. CLIN THER 2010;32 (4):615-625 [PubMed]
Huijgen R, Kindt I, Fouchier SW, Defesche JC, Hutten BA, Kastelein JJP, Vissers MN, Functionality of Sequence Variants in the Genes Coding for the Low-Density Lipoprotein Receptor and Apolipoprotein B in Individuals with Inherited Hypercholesterolemia. HUM MUTAT 2010;31 (6):752-760 [PubMed]
Huijgen R, Kindt I, Verhoeven SBJ, Sijbrands EJG, Vissers MN, Kastelein JJP, Hutten BA, Two Years after Molecular Diagnosis of Familial Hypercholesterolemia: Majority on Cholesterol-Lowering Treatment but a Minority Reaches Treatment Goal. PLOS ONE 2010;5 (2):e9220 [PubMed]
Jakulj L, Vissers MN, Groen AK, Hutten BA, Lutjohann D, Veltri EP, Kastelein JJP, Baseline cholesterol absorption and the response to ezetimibe/simvastatin therapy: a post-hoc analysis of the ENHANCE trial. J LIPID RES 2010;51 (4):755-762 [PubMed]
Jakulj L, Vissers MN, Tanck MWT, Hutten BA, Stellaard F, Kastelein JJP, Dallinga-Thie GM, ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysis. J LIPID RES 2010;51 (10):3016-3023 [PubMed]
Jakulj L, Vissers MN, van Roomen CP, van der Veen JN, Vrins CLJ, Kunne C, Stellaard F, Kastelein JJP, Groen AK, Ezetimibe stimulates faecal neutral sterol excretion depending on abcg8 function in mice. FEBS LETT 2010;584 (16):3625-3628 [PubMed]
Kusters DM, Vissers MN, Wiegman A, Kastelein JJ, Hutten BA, Treatment of dyslipidaemia in childhood. EXPERT OPIN PHARMACO 2010;11 (5):739-753 [PubMed]
Motazacker MM, Kastelein JJ, Kuivenhoven JA, Are high-density lipoprotein genes and their products targets for therapy?. CURR OPIN LIPIDOL 2010;21 (2):157-158 [PubMed]
Oosterveer DM, Versmissen J, Yazdanpanah M, Defesche JC, Kastelein JJP, Sijbrands EJG, The risk of tendon xanthomas in familial hypercholesterolaemia is influenced by variation in genes of the reverse cholesterol transport pathway and the low-density lipoprotein oxidation pathway. EUR HEART J 2010;31 (8):1007-1012 [PubMed]
Pedersen TR, Cater NB, Faergeman O, Kastelein JJP, Olsson AG, Tikkanen MJ, Holme I, Larsen ML, Lindahl C, Szarek M, Comparison of atorvastatin 80 mg/day versus simvastatin 20 to 40 mg/day on frequency of cardiovascular events late (five years) after acute myocardial infarction (from the Incremental Decrease in End Points through Aggressive Lipid Lowering [IDEAL] trial). AM J CARDIOL 2010;106 (3):354-359 [PubMed]
Pijlman AH, Huijgen R, Verhagen SN, Imholz BPM, Liem AH, Kastelein JJP, Abbink EJ, Stalenhoef AFH, Visseren FLJ, Evaluation of cholesterol lowering treatment of patients with familial hypercholesterolemia: A large cross-sectional study in The Netherlands. ATHEROSCLEROSIS 2010;209 (1):189-194 [PubMed]
Rana JS, Visser ME, Arsenault BJ, Després JP, Stroes ESG, Kastelein JJP, Wareham NJ, Boekholdt SM, Khaw KT, Metabolic dyslipidemia and risk of future coronary heart disease in apparently healthy men and women: The EPIC-Norfolk prospective population study. INT J CARDIOL 2010;143 (3):399-404 [PubMed]
Reuwer AQ, Reuwer PJHM, van der Post JA, Cramer MJ, Kastelein JJP, Twickler MTB, Prolactin fragmentation by trophoblastic matrix metalloproteinases as a possible contributor to peripartum cardiomyopathy and pre-eclampsia. MED HYPOTHESES 2010;74 (2):348-352 [PubMed]
Ridker PM, Genest J, Boekholdt SM, Libby P, Gotto AM, Nordestgaard BG, Mora S, Macfadyen JG, Glynn RJ, Kastelein JJ, HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial. LANCET 2010;376 (9738):333-339 [PubMed]
Ridker PM, Genest J, Kastelein JJP, HDL cholesterol and residual risk of first cardiovascular events - Authors' reply. LANCET 2010;376 (9754):1738-1739 [PubMed]
Ridker PM, Macfadyen JG, Nordestgaard BG, Koenig W, Kastelein JJP, Genest J, Glynn RJ, Rosuvastatin for Primary Prevention Among Individuals With Elevated High-Sensitivity C-Reactive Protein and 5% to 10% and 10% to 20% 10-Year Risk Implications of the Justification for Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) Trial for "Intermediate Risk". CIRC-CARDIOVASC QUAL 2010;3 (5):447-452 [PubMed]
Sarwar N, Sandhu MS, Ricketts SL, Butterworth AS, Di Angelantonio E, Boekholdt SM, Ouwehand W, Watkins H, Samani NJ, Saleheen D, Lawlor D, Reilly MP, Hingorani AD, Talmud PJ, Danesh J [Contributors: Braund PS, Hall AS, Samani NJ, Thompson J, März W, Ouwehand W, Sivapalaratnam S, Soranzo N, Trip M, Lawlor DA, Casas JP, Ebrahim S, Arsenault BJ, Boekholdt SM, Khaw KT, Ricketts SL, Sandhu MS, Wareham NJ, Grallert H, Illig T, Humphries SE, Talmud T, Rader DJ, He J, Reilly MP, Clarke R, Hamsten A, Hopewell JC, Watkins H, Saleheen D, Frossard P, Deloukas P, Danesh J, Ye S, Simpson IA, Onat A, Kömürcü-Bayrak E, Martinelli N, Olivieri O, Girelli D, Hingorani AD, Kivimäki M, Kumari M, Aouizerat BE, Baum L, Campos H, Chaaba R, Chen BS, Cho EY, Evans D, Hill J, Hsu LA, Hubacek JA, Lai CQ, Lee JH, Klos K, Liu H, Masana L, Melegh B, Nabika T, Ribalta J, Ruiz-Narvaez E, Thomas GN, Tomlinson B, Szalai C, Vaverkova H, Yamada Y, Yang Y, Kastelein JJ, Tipping RW, Ford CE, Pressel SL, Ballantyne C, Brautbar A, Knuiman M, Whincup PH, Wannamethee SG, Morris RW, Kiechl S, Willeit J, Santer P, Mayr A, Wald N, Yarnell JWG, Gallacher J, Casiglia E, Tikhonoff V, Cushman M, Psaty BM, Tracy RP, Tybjaerg-Hansen A, Nordestgaard BG, Benn M, Frikke-Schmidt R, Giampaoli S, Palmieri L, Panico S, Vanuzzo D, Pilotto L, de la Cámara AG, Gómez-Gerique JA, Simons L, McCallum J, Friedlander Y, Fowkes FGR, Lee AJ, Taylor J, Guralnik JM, Phillips CL, Wallace R, Blazer DG, Khaw KT, Brenner H, Raum E, Müller H, Rothenbacher D, Jansson JH, Wennberg P, Nissinen A, Donfrancesco C, Salomaa V, Harald K, Jousilahti P, Vartiainen E, D'Agostino RB, Vasan RS, Pencina MJ, Bladbjerg EM, Jørgensen T, Møller L, Jespersen J, Dankner R, Chetrit A, Lubin F, Björkelund C, Lissner L, Bengtsson C, Cremer P, Nagel D, Rodriguez B, Dekker JM, Nijpels G, Stehouwer CDA, Sato S, Iso H, Kitamura A, Noda H, Salonen JT, Nyyssönen K, Tuomainen TP, Voutilainen S, Meade TW, Cooper JA, Kuller LH, Grandits G, Gillum R, Mussolino M, Rimm E, Hankinson S, Manson JAE, Pai JK, Bauer KA, Naito Y, Amouyel P, Arveiler D, Evans A, Ferrières J, Schulte H, Assmann G, Packard CJ, Sattar N, Westendorp RG, Buckley BM, Cantin B, Lamarche B, Després JP, Dagenais GR, Barrett-Connor E, Wingard DL, Bettencourt R, Gudnason V, Aspelund T, Sigurdsson G, Thorsson B, Trevisan M, Tunstall-Pedoe H, Tavendale R, Lowe GDO, Woodward M, Howard BV, Zhang Y, Best L, Umans J, Ben-Shlomo Y, Davey-Smith G, Njølstad I, Mathiesen EB, Løchen ML, Wilsgaard T, Ingelsson E, Lind L, Giedraitis V, Michaëlsson K, Brunner E, Shipley M, Ridker P, Buring J, Shepherd J, Cobbe SM, Ford I, Robertson M, Ibañez AM, Feskens EJM, Kromhout D, Walker M, Watson S, Collins R, Di Angelantonio E, Kaptoge S, Perry PL, Sarwar N, Thompson A, Thompson SG, White IR, Wood AM]] , Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. LANCET 2010;375 (9726):1634-1639 [PubMed]
Sivapalaratnam S, Boekholdt SM, Trip MD, Sandhu MS, Luben R, Kastelein JJP, Wareham NJ, Khaw KT, Family history of premature coronary heart disease and risk prediction in the EPIC-Norfolk prospective population study. HEART 2010;96 (24):1985-1989 [PubMed]
Sivapalaratnam S, van Loendersloot LL, Hutten BA, Kastelein JJP, Trip MD, de Groot E, Long-term LDL-c lowering in heterozygous familial hypercholesterolemia normalizes carotid intima-media thickness. ATHEROSCLEROSIS 2010;212 (2):571-574 [PubMed]
Sofat R, Hingorani AD, Smeeth L, Humphries SE, Talmud PJ, Cooper J, Shah T, Sandhu MS, Ricketts SL, Boekholdt SM, Wareham N, Khaw KT, Kumari M, Kivimaki M, Marmot M, Asselbergs FW, van der Harst P, Dullaart RPF, Navis G, van Veldhuisen DJ, van Gilst WH, Thompson JF, McCaskie P, Palmer LJ, Arca M, Quagliarini F, Gaudio C, Cambien F, Nicaud V, Poirer O, Gudnason V, Isaacs A, Witteman JCM, van Duijn CM, Pencina M, Vasan RS, D'Agostino RB Sr, Ordovas J, Li TY, Kakko S, Kauma H, Savolainen MJ, Kesäniemi YA, Sandhofer A, Paulweber B, Sorli JV, Goto A, Yokoyama S, Okumura K, Horne BD, Packard C, Freeman D, Ford I, Sattar N, McCormack V, Lawlor DA, Ebrahim S, Smith GD, Kastelein JJP, Deanfield J, Casas JP, Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms. CIRCULATION 2010;121 (1):52-62 [PubMed]
Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ, Johansen CT, Fouchier SW, Isaacs A, Peloso GM, Barbalic M, Ricketts SL, Bis JC, Aulchenko YS, Thorleifsson G, Feitosa MF, Chambers J, Orho-Melander M, Melander O, Johnson T, Li X, Guo X, Li M, Shin Cho Y, Jin Go M, Jin Kim Y, Lee JY, Park T, Kim K, Sim X, Twee-Hee Ong R, Croteau-Chonka DC, Lange LA, Smith JD, Song K, Hua Zhao J, Yuan X, Luan Ja, Lamina C, Ziegler A, Zhang W, Zee RYL, Wright AF, Witteman JCM, Wilson JF, Willemsen G, Wichmann HE, Whitfield JB, Waterworth DM, Wareham NJ, Waeber G, Vollenweider P, Voight BF, Vitart V, Uitterlinden AG, Uda M, Tuomilehto J, Thompson JR, Tanaka T, Surakka I, Stringham HM, Spector TD, Soranzo N, Smit JH, Sinisalo J, Silander K, Sijbrands EJG, Scuteri A, Scott J, Schlessinger D, Sanna S, Salomaa V, Saharinen J, Sabatti C, Ruokonen A, Rudan I, Rose LM, Roberts R, Rieder M, Psaty BM, Pramstaller PP, Pichler I, Perola M, Penninx BWJH, Pedersen NL, Pattaro C, Parker AN, Pare G, Oostra BA, O'Donnell CJ, Nieminen MS, Nickerson DA, Montgomery GW, Meitinger T, McPherson R, McCarthy MI, McArdle W, Masson D, Martin NG, Marroni F, Mangino M, Magnusson PKE, Lucas G, Luben R, Loos RJF, Lokki ML, Lettre G, Langenberg C, Launer LJ, Lakatta EG, Laaksonen R, Kyvik KO, Kronenberg F, König IR, Khaw KT, Kaprio J, Kaplan LM, Johansson A, Jarvelin MR, Janssens ACJW, Ingelsson E, Igl W, Hovingh GK, Hottenga JJ, Hofman A, Hicks AA, Hengstenberg C, Heid IM, Hayward C, Havulinna AS, Hastie ND, Harris TB, Haritunians T, Hall AS, Gyllensten U, Guiducci C, Groop LC, Gonzalez E, Gieger C, Freimer NB, Ferrucci L, Erdmann J, Elliott P, Ejebe KG, Döring A, Dominiczak AF, Demissie S, Deloukas P, de Geus EJC, de Faire U, Crawford G, Collins FS, Chen YdI, Caulfield MJ, Campbell H, Burtt NP, Bonnycastle LL, Boomsma DI, Boekholdt SM, Bergman RN, Barroso I, Bandinelli S, Ballantyne CM, Assimes TL, Quertermous T, Altshuler D, Seielstad M, Wong TY, Tai ES, Feranil AB, Kuzawa CW, Adair LS, Taylor HA Jr, Borecki IB, Gabriel SB, Wilson JG, Holm H, Thorsteinsdottir U, Gudnason V, Krauss RM, Mohlke KL, Ordovas JM, Munroe PB, Kooner JS, Tall AR, Hegele RA, Kastelein JJP, Schadt EE, Rotter JI, Boerwinkle E, Strachan DP, Mooser V, Stefansson K, Reilly MP, Samani NJ, Schunkert H, Cupples LA, Sandhu MS, Ridker PM, Rader DJ, van Duijn CM, Peltonen L, Abecasis GR, Boehnke M, Kathiresan S, Biological, clinical and population relevance of 95 loci for blood lipids. NATURE 2010;466 (7307):707-713 [PubMed]
Tsimikas S, Mallat Z, Talmud PJ, Kastelein JJP, Wareham NJ, Sandhu MS, Miller ER, Benessiano J, Tedgui A, Witztum JL, Khaw KT, Boekholdt SM, Oxidation-Specific Biomarkers, Lipoprotein(a), and Risk of Fatal and Nonfatal Coronary Events. J AM COLL CARDIOL 2010;56 (12):946-955 [PubMed]
van der Graaf A. Familial hypercholesterolemia. Cardiovascular disease prevention from childhood into adolescence. s.l.: s.n.; 2010. 164p. ISBN 9789090255767 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP, Wijburg FA; copromotor(s): Vissers MN, Hutten BA)
van der Graaf A, Vissers MN, Gaudet D, Brisson D, Sivapalaratnam S, Roseboom TJ, Jansen ACM, Kastelein JJP, Hutten BA, Dyslipidemia of Mothers With Familial Hypercholesterolemia Deteriorates Lipids in Adult Offspring. ARTERIOSCL THROM VAS 2010;30 (12):2673-U623 [PubMed]
van Leuven SI, van Wijk DF, Volger OL, de Vries JPPM, van der Loos CM, de Kleijn DVP, Horrevoets AJG, Tak PP, van der Wal AC, de Boer OJ, Pasterkamp G, Hayden MR, Kastelein JJP, Stroes ES, Mycophenolate mofetil attenuates plaque inflammation in patients with symptomatic carotid artery stenosis. ATHEROSCLEROSIS 2010;211 (1):231-236 [PubMed]
van Wijk DF, van Leuven SI, Sandhu MS, Tanck MW, Hutten BA, Wareham NJ, Kastelein JJP, Stroes ESG, Khaw KT, Boekholdt SM, Chemokine Ligand 2 Genetic Variants, Serum Monocyte Chemoattractant Protein-1 Levels, and the Risk of Coronary Artery Disease. ARTERIOSCL THROM VAS 2010;30 (7):1460-U466 [PubMed]
Vergeer M, Boekholdt SM, Sandhu MS, Ricketts SL, Wareham NJ, Brown MJ, de Faire U, Leander K, Gigante B, Kavousi M, Hofman A, Uitterlinden AG, van Duijn CM, Witteman JCM, Jukema JW, Schadt EE, van der Schoot E, Kastelein JJP, Khaw KT, Dullaart RPF, van Tol A, Trip MD, Dallinga-Thie GM, Genetic Variation at the Phospholipid Transfer Protein Locus Affects Its Activity and High-Density Lipoprotein Size and Is a Novel Marker of Cardiovascular Disease Susceptibility. CIRCULATION 2010;122 (5):470-U66 [PubMed]
Vergeer M, Brunham LR, Koetsveld J, Kruit JK, Verchere CB, Kastelein JJP, Hayden MR, Stroes ESG, Carriers of loss-of-function mutations in ABCA1 display pancreatic beta-cell dysfunction. DIABETES CARE 2010;33 (4):869-874 [PubMed]
Vergeer M, Cohn DM, Boekholdt SM, Sandhu MS, Prins HM, Ricketts SL, Wareham NJ, Kastelein JJP, Khaw KT, Kamphuisen PW, Dallinga-Thie GM, Lack of association between common genetic variation in endothelial lipase (LIPG) and the risk for CAD and DVT. ATHEROSCLEROSIS 2010;211 (2):558-564 [PubMed]
Vergeer M, Holleboom AG, Kastelein JJP, Kuivenhoven JA, The HDL hypothesis: does high-density lipoprotein protect from atherosclerosis?. J LIPID RES 2010;51 (8):2058-2073 [PubMed]
Vergeer M, Zhou R, Bots ML, Duivenvoorden R, Koglin J, Akdim F, Mitchel YB, Huijgen R, Sapre A, de Groot E, Sijbrands EJG, Pasternak RC, Gagné C, Marais AD, Ballantyne CM, Isaacsohn JL, Stalenhoef AFH, Kastelein JJP, Carotid Atherosclerosis Progression in Familial Hypercholesterolemia Patients A Pooled Analysis of the ASAP, ENHANCE, RADIANCE 1, and CAPTIVATE Studies. CIRC-CARDIOVASC IMAG 2010;3 (4):398-U70 [PubMed]
Visser ME, Akdim F, Tribble DL, Nederveen AJ, Kwoh TJ, Kastelein JJP, Trip MD, Stroes ESG, Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia. J LIPID RES 2010;51 (5):1057-1062 [PubMed]
Visser ME, Kastelein JJ, Stroes ES, Apolipoprotein B synthesis inhibition: results from clinical trials. CURR OPIN LIPIDOL 2010;21 (4):319-323 [PubMed]
Arsenault BJ, Boekholdt SM, Kastelein JJP, Després JP. Comprehensive lipid profiling beyond LDL in: Naghavi M, editors. Asymptomatic atherosclerosis; pathophysiology, detection & treatment. New York: Humana Press; 2009., p. 210-221
Arsenault BJ, Lemieux I, Després JP, Gagnon P, Wareham NJ, Stroes ESG, Kastelein JJP, Khaw KT, Boekholdt SM, HDL particle size and the risk of coronary heart disease in apparently healthy men and women: The EPIC-Norfolk prospective population study. ATHEROSCLEROSIS 2009;206 (1):276-281 [PubMed]
Arsenault BJ, Rana JS, Stroes ESG, Després JP, Shah PK, Kastelein JJP, Wareham NJ, Boekholdt SM, Khaw KT, Beyond Low-Density Lipoprotein Cholesterol Respective Contributions of Non-High-Density Lipoprotein Cholesterol Levels, Triglycerides, and the Total Cholesterol/High-Density Lipoprotein Cholesterol Ratio to Coronary Heart Disease Risk in Apparently Healthy Men and Women. J AM COLL CARDIOL 2009;55 (1):35-41 [PubMed]
Avis HJ, Hutten BA, Twickler MTB, Kastelein JJP, van der Post JAM, Stalenhoef AF, Vissers MN, Pregnancy in women suffering from familial hypercholesterolemia: a harmful period for both mother and newborn?. CURR OPIN LIPIDOL 2009;20 (6):484-490 [PubMed]
Avis HJ, Vissers MN, Wijburg FA, Kastelein JJP, Hutten BA, The use of lipid-lowering drug therapy in children and adolescents. CURR OPIN INVEST DR 2009;10 (3):224-231 [PubMed]
Beigneux AP, Franssen R, Bensadoun A, Gin P, Melford K, Peter J, Walzem RL, Weinstein MM, Davies BSJ, Kuivenhoven JA, Kastelein JJP, Fong LG, Dallinga-Thie GM, Young SG, Chylomicronemia With a Mutant GPIHBP1 (Q115P) That Cannot Bind Lipoprotein Lipase. ARTERIOSCL THROM VAS 2009;29 (6):956-U447 [PubMed]
Birjmohun RS, Vergeer M, Stroes ESG, Sandhu MS, Ricketts SL, Tanck MW, Wareham NJ, Jukema JW, Kastelein JJP, Khaw KT, Boekholdt SM, Both Paraoxonase-1 Genotype and Activity Do Not Predict the Risk of Future Coronary Artery Disease; the EPIC-Norfolk Prospective Population Study. PLOS ONE 2009;4 (8):e6809 [PubMed]
Bisoendial RJ, Birjmohun RS, Akdim F, van 't Veer C, Spek CA, Hartman D, de Groot ER, Bankaitis-Davis DM, Kastelein JJP, Stroes ESG, C-Reactive Protein Elicits White Blood Cell Activation in Humans. AM J MED 2009;122 (6):582.e1-582.e9 [PubMed]
Broekhuizen LN, Mooij HL, Kastelein JJP, Stroes ESG, Vink H, Nieuwdorp M, Endothelial glycocalyx as potential diagnostic and therapeutic target in cardiovascular disease. CURR OPIN LIPIDOL 2009;20 (1):57-62 [PubMed]
de Fost M, Langeveld M, Franssen R, Hutten BA, Groener JEM, de Groot E, Mannens MM, Bikker H, Aerts JMFG, Kastelein JJP, Hollak CEM, Low HDL cholesterol levels in type I Gaucher disease do not lead to an increased risk of cardiovascular disease. ATHEROSCLEROSIS 2009;204 (1):267-272 [PubMed]
Duivenvoorden R, de Groot E, Afzali H, Vanbavel ET, de Boer OJ, Laméris JS, Fayad ZA, Stroes ESG, Kastelein JJP, Nederveen AJ, Comparison of In Vivo Carotid 3.0-T Magnetic Resonance to B-Mode Ultrasound Imaging and Histology in a Porcine Model. JACC-CARDIOVASC IMAG 2009;2 (6):744-750 [PubMed]
Duivenvoorden R, de Groot E, Elsen BM, Laméris JS, van der Geest RJ, Stroes ES, Kastelein JJP, Nederveen AJ, In vivo quantification of carotid artery wall dimensions: 3.0-Tesla MRI versus B-mode ultrasound imaging. CIRC-CARDIOVASC IMAG 2009;2 (3):235-242 [PubMed]
Duivenvoorden R, de Groot E, Kastelein JJP, Carotid Atherosclerosis Progression and ACAT Inhibition Reply. JAMA-J AM MED ASSOC 2009;302 (3):256-257
Duivenvoorden R, de Groot E, Stroes ESG, Kastelein JJP, Surrogate markers in clinical trials-Challenges and opportunities. ATHEROSCLEROSIS 2009;206 (1):8-16 [PubMed]
El-Harchaoui K. The puzzle of high-density lipoprotein in cardiovascular prevention. s.l.: s.n.; 2009. 173p. ISBN 9789085596042 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Stroes ESG, Kuivenhoven JA)
El Harchaoui K, Arsenault BJ, Franssen R, Després JP, Hovingh GK, Stroes ESG, Otvos JD, Wareham NJ, Kastelein JJP, Khaw KT, Boekholdt SM, High-Density Lipoprotein Particle Size and Concentration and Coronary Risk. ANN INTERN MED 2009;150 (2):84-U43 [PubMed]
Faergeman O, Holme I, Fayyad R, Bhatia S, Grundy SM, Kastelein JJP, LaRosa JC, Larsen ML, Lindahl C, Olsson AG, Tikkanen MJ, Waters DD, Pedersen TR, Plasma Triglycerides and Cardiovascular Events in the Treating to New Targets and Incremental Decrease in End-Points Through Aggressive Lipid Lowering Trials of Statins in Patients With Coronary Artery Disease. AM J CARDIOL 2009;104 (4):459-463 [PubMed]
Franssen R, Sankatsing RR, Hassink E, Hutten B, Ackermans MT, Brinkman K, Oesterholt R, Arenas-Pinto A, Storfer SP, Kastelein JJ, Sauerwein HP, Reiss P, Stroes ES, Nevirapine Increases High-Density Lipoprotein Cholesterol Concentration by Stimulation of Apolipoprotein A-I Production. ARTERIOSCL THROM VAS 2009;29 (9):1336-1341 [PubMed]
Franssen R, Vergeer M, Stroes ESG, Kastelein JJP, Combination statin-fibrate therapy: safety aspects. DIABETES OBES METAB 2009;11 (2):89-94 [PubMed]
Glynn RJ, Danielson E, Fonseca FAH, Genest J, Gotto AM Jr, Kastelein JJP, Koenig W, Libby P, Lorenzatti AJ, Macfadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Ridker PM, A Randomized Trial of Rosuvastatin in the Prevention of Venous Thromboembolism. NEW ENGL J MED 2009;360 (18):1851-1861 [PubMed]
Harchaoui KE, Franssen R, Hovingh GK, Bisoendial RJ, Stellaard F, Kuipers F, Kastelein JJP, Kuivenhoven JA, Stroes ESG, Groen AK, Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia. ATHEROSCLEROSIS 2009;207 (2):614-616 [PubMed]
Harchaoui KEL, Visser ME, Kastelein JJP, Stroes ES, Dallinga-Thie GM, Triglycerides and cardiovascular risk. CURR CARDIOL REV 2009;5 (3):216-222 [PubMed]
Hassing C, Twickler M, Brunekreef B, Cassee F, Doevendans P, Kastelein J, Cramer MJ, Particulate air pollution, coronary heart disease and individual risk assessment: a general overview. EUR J CARDIOV PREV R 2009;16 (1):10-15 [PubMed]
Hassing HC, Twickler TB, Kastelein JJP, Cramer MJM, Cassee FR, Air pollution as noxious environmental factor in the development of cardiovascular disease. NETH J MED 2009;67 (4):116-121 [PubMed]
Henneman P, van der Sman-de Beer F, Moghaddam PH, Huijts P, Stalenhoef AFH, Kastelein JJP, van Duijn CM, Havekes LM, Frants RR, van Dijk KW, Smelt AHM, The expression of type III hyperlipoproteinemia: involvement of lipolysis genes. EUR J HUM GENET 2009;17 (5):620-628 [PubMed]
Holme I, Strandberg TE, Faergeman O, Kastelein JJP, Olsson AG, Tikkanen MJ, Larsen ML, Lindahl C, Pedersen TR, Congestive heart failure is associated with lipoprotein components in statin-treated patients with coronary heart disease Insights from the Incremental Decrease in End points Through Aggressive Lipid Lowering Trial (IDEAL). ATHEROSCLEROSIS 2009;205 (2):522-527 [PubMed]
Holme I, Szarek M, Cater NB, Faergeman O, Kastelein JJP, Olsson AG, Tikkanen MJ, Larsen ML, Lindahl C, Pedersen TR, Adherence-adjusted efficacy with intensive versus standard statin therapy in patients with acute myocardial infarction in the IDEAL study. EUR J CARDIOV PREV R 2009;16 (3):315-320 [PubMed]
Kastelein JJP, Bots ML, Statin therapy with ezetimibe or niacin in high-risk patients. NEW ENGL J MED 2009;361 (22):2180-2183 [PubMed]
Koeijvoets KCMC, Mooijaart SP, Dallinga-Thie GM, Defesche JC, Steyerberg EW, Westendorp RGJ, Kastelein JJP, van Hagen PM, Sijbrands EJG, Complement factor H Y402H decreases cardiovascular disease risk in patients with familial hypercholesterolaemia. EUR HEART J 2009;30 (5):618-623 [PubMed]
Koeijvoets KCMC, van der Net JB, Dallinga-Thie GM, Steyerberg EW, Mensink RP, Kastelein JJP, Sijbrands EJG, Plat J, ABCG8 gene polymorphisms, plasma cholesterol concentrations, and risk of cardiovascular disease in familial hypercholesterolemia. ATHEROSCLEROSIS 2009;204 (2):453-458 [PubMed]
Meuwese MC, de Groot E, Duivenvoorden R, Trip MD, Ose L, Maritz FJ, Basart DCG, Kastelein JJP, Habib R, Davidson MH, Zwinderman AH, Schwocho LR, Stein EA, ACAT Inhibition and Progression of Carotid Atherosclerosis in Patients With Familial Hypercholesterolemia The CAPTIVATE Randomized Trial. JAMA-J AM MED ASSOC 2009;301 (11):1131-1139 [PubMed]
Meuwese MC, Mooij HL, Nieuwdorp M, van Lith B, Marck R, Vink H, Kastelein JJP, Stroes ESG, Partial recovery of the endothelial glycocalyx upon rosuvastatin therapy in patients with heterozygous familial hypercholesterolemia. J LIPID RES 2009;50 (1):148-153 [PubMed]
Mingozzi F, Meulenberg JJ, Hui DJ, Basner-Tschakarjan E, Hasbrouck NC, Edmonson SA, Hutnick NA, Betts MR, Kastelein JJ, Stroes ES, High KA, AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells. BLOOD 2009;114 (10):2077-2086 [PubMed]
Nieuwdorp M, Meuwese MC, Mooij HL, van Lieshout MHP, Hayden A, Levi M, Meijers JCM, Ince C, Kastelein JJP, Vink H, Stroes ESG, Tumor necrosis factor-alpha inhibition protects against endotoxin-induced endothelial glycocalyx perturbation. ATHEROSCLEROSIS 2009;202 (1):296-303 [PubMed]
Oosterveer DM, Versmissen J, Yazdanpanah M, van der Net JB, Defesche JC, Kastelein JJP, Sijbrands EJG, 5-Lipoxygenase activating protein (ALOX5AP) gene variants associate with the presence of xanthomas in familial hypercholesterolemia. ATHEROSCLEROSIS 2009;206 (1):223-227 [PubMed]
Rana JS, Cote M, Després JP, Sandhu MS, Talmud PJ, Ninio E, Wareham NJ, Kastelein JJP, Zwinderman AH, Khaw KT, Boekholdt SM, Inflammatory biomarkers and the prediction of coronary events among people at intermediate risk: the EPIC-Norfolk prospective population study. HEART 2009;95 (20):1682-1687 [PubMed]
Regieli JJ, Jukema JW, Doevendans PA, Zwinderman AH, Kastelein JJ, Grobbee DE, van der Graaf Y, Paraoxonase variants relate to 10-year risk in coronary artery disease: impact of a high-density lipoprotein-bound antioxidant in secondary prevention. J AM COLL CARDIOL 2009;54 (14):1238-1245 [PubMed]
Regieli JJ, Jukema JW, Doevendans PA, Zwinderman AH, van der Graaf Y, Kastelein JJ, Grobbee DE, PPAR gamma variant influences angiographic outcome and 10-year cardiovascular risk in male symptomatic coronary artery disease patients. DIABETES CARE 2009;32 (5):839-844 [PubMed]
Rensing KL, Kastelein JJP, Twickler M, Is Insulin the Preferred Compound in Lowering Glucose Levels in Patients After a Myocardial Infarction?. ARCH INTERN MED 2009;169 (17):1636-1637 [PubMed]
Reuwer AQ, Nieuwland R, Fernandez I, Goffin V, van Tiel CM, Schaap MCL, Berckmans RJ, Kastelein JJP, Twickler MTB, Prolactin does not affect human platelet aggregation or secretion. THROMB HAEMOSTASIS 2009;101 (6):1119-1127 [PubMed]
Reuwer AQ, Twickler MTB, Hutten BA, Molema FW, Wareham NJ, Dallinga-Thie GM, Bogorad RL, Goffin V, Smink-Bol M, Kastelein JJP, Boekholdt SM, Khaw KT, Prolactin Levels and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women. CIRC-CARDIOVASC GENE 2009;2 (4):389-U239 [PubMed]
Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, Macfadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ, Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. LANCET 2009;373 (9670):1175-1182 [PubMed]
Ridker PM, Danielson E, Fonseca FAH, Genest J, Gotto AM Jr, Kastelein JJP, Koenig W, Libby P, Lorenzatti AJ, Macfadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ, Reduction in C-Reactive Protein and Low-Density Lipoprotein Cholesterol and Cardiovascular Event Rates After Initiation of Rosuvastatin: A Prospective Study of the justification for the Use of Statins in Prevention: An Intervention, Trial Evaluating Rosuvastatin Trial. OBSTET GYNECOL SURV 2009;64 (9):596-597
Ridker PM, Macfadyen JG, Fonseca FAH, Genest J, Gotto AM, Kastelein JJP, Koenig W, Libby P, Lorenzatti AJ, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ, Number Needed to Treat With Rosuvastatin to Prevent First Cardiovascular Events and Death Among Men and Women With Low Low-Density Lipoprotein Cholesterol and Elevated High-Sensitivity C-Reactive Protein Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER). CIRC-CARDIOVASC QUAL 2009;2 (6):616-623 [PubMed]
Sankatsing RR, Wit FW, Vogel M, de Groot E, Brinkman K, Rockstroh JK, Kastelein JJP, Stroes ESG, Reiss P, Increased carotid intima-media thickness in HIV patients treated with protease inhibitors as compared to non-nucleoside reverse transcriptase inhibitors. ATHEROSCLEROSIS 2009;202 (2):589-595 [PubMed]
Semb AG, Ueland T, Aukrust P, Wareham NJ, Luben R, Gullestad L, Kastelein JJP, Khaw KT, Boekholdt SM, Osteoprotegerin and soluble receptor activator of nuclear factor-kappaB ligand and risk for coronary events: a nested case-control approach in the prospective EPIC-Norfolk population study 1993-2003. ARTERIOSCL THROM VAS 2009;29 (6):975-980 [PubMed]
Stein EA, Stroes ESG, Steiner G, Buckley BM, Capponi AM, Burgess T, Niesor EJ, Kallend D, Kastelein JJP, Safety and tolerability of dalcetrapib. AM J CARDIOL 2009;104 (1):82-91 [PubMed]
Strandberg TE, Holme I, Faergeman O, Kastelein JJP, Lindahl C, Larsen ML, Olsson AG, Pedersen TR, Tikkanen MJ, Comparative Effect of Atorvastatin (80 mg) Versus Simvastatin (20 to 40 mg) in Preventing Hospitalizations for Heart Failure in Patients With Previous Myocardial Infarction. AM J CARDIOL 2009;103 (10):1381-1385 [PubMed]
Strang AC, Hovingh GK, Stroes ESG, Kastelein JJP, The genetics of high-density lipoprotein metabolism: clinical relevance for therapeutic approaches. AM J CARDIOL 2009;104 (10 Suppl):22E-31E [PubMed]
Stroes ESG, Kastelein JJP, Bénardeau A, Kuhlmann O, Blum D, Campos LA, Clerc RG, Niesor EJ, Dalcetrapib: no off-target toxicity on blood pressure or on genes related to the renin-angiotensin-aldosterone system in rats. BRIT J PHARMACOL 2009;158 (7):1763-1770 [PubMed]
Taylor J, Kastelein JJP, "This Will Be About Making the Databases Large Enough so we Find the Few Diamonds That We Need". CIRCULATION 2009;119 (14):F82-F84
Thompson JF, Hyde CL, Wood LS, Paciga SA, Hinds DA, Cox DR, Hovingh GK, Kastelein JJP, Comprehensive Whole-Genome and Candidate Gene Analysis for Response to Statin Therapy in the Treating to New Targets (TNT) Cohort. CIRC-CARDIOVASC GENE 2009;2 (2):173-U240 [PubMed]
Tikkanen MJ, Holme I, Cater NB, Szarek M, Faergeman O, Kastelein JJP, Olsson AG, Larsen ML, Lindahl C, Pedersen TR [Contributors: Pedersen TR, Faergeman O, Kastelein JJP, Olsson AG, Tikkanen MJ, Holme I, Larsen ML, Lindahl C, Bhatia S]] , Comparison of efficacy and safety of atorvastatin (80 mg) to simvastatin (20 to 40 mg) in patients aged <65 versus >or=65 years with coronary heart disease (from the Incremental DEcrease through Aggressive Lipid Lowering [IDEAL] study). AM J CARDIOL 2009;103 (5):577-582 [PubMed]
Tikkanen MJ, Szarek M, Fayyad R, Holme I, Cater NB, Faergeman O, Kastelein JJP, Olsson AG, Larsen ML, Lindahl C, Pedersen TR, Total Cardiovascular Disease Burden: Comparing Intensive With Moderate Statin Therapy Insights From the IDEAL (Incremental Decrease in End Points Through Aggressive Lipid Lowering) Trial. J AM COLL CARDIOL 2009;54 (25):2353-2357 [PubMed]
Vaessen SFC. Apolipoproteins A-I and A-V as gene therapeutic targets to intervene in lipid metabolism. s.l.: s.n.; 2009. 188p. ISBN 97890902452225 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Kuivenhoven JA, Schaap FG)
van der Graaf A, Kastelein JJP, Wiegman A, Heterozygous familial hypercholesterolaemia in childhood: Cardiovascular risk prevention. J INHERIT METAB DIS 2009;32 (6):699-705 [PubMed]
van der Net JB, Janssens ACJW, Defesche JC, Kastelein JJP, Sijbrands EJG, Steyerberg EW, Usefulness of Genetic Polymorphisms and Conventional Risk Factors to Predict Coronary Heart Disease in Patients With Familial Hypercholesterolemia. AM J CARDIOL 2009;103 (3):375-380 [PubMed]
van der Net JB, Versmissen J, Oosterveer DM, Defesche JC, Yazdanpanah M, Aouizerat BE, Steyerberg EW, Malloy MJ, Pullinger CR, Kane JP, Kastelein JJP, Sijbrands EJG, Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia. ATHEROSCLEROSIS 2009;203 (2):472-478 [PubMed]
van der Steeg WA. Improving cardiovascular disease prevention: from risk assessment to novel therapy. s.l.: s.n.; 2009. 166p. ISBN 9789071382840 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Kuivenhoven JA, Stroes ESG)
van Hoek M, van Tol A, van Vark-van der Zee LC, Jansen H, Kastelein JJP, Sijbrands EJG, Dallinga-Thie GM, Role of plasma adiponectin on the HDL-cholesterol raising effect of atorvastatin in patients with type 2 diabetes. CURR MED RES OPIN 2009;25 (1):93-101 [PubMed]
van Leuven SI. Inflammation and its echo in atherosclerosis. s.l.: s.n.; 2009. 339p. ISBN 9789490122386 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Stroes ESG)
van Leuven SI, Birjmohun RS, Franssen R, Bisoendial RJ, de Kort H, Levels JHM, Basser RL, Meijers JCM, Kuivenhoven JA, Kastelein JJ, Stroes ES, ApoAI-phosphatidylcholine infusion neutralizes the atherothrombotic effects of C-reactive protein in humans. J THROMB HAEMOST 2009;7 (2):347-354 [PubMed]
van Wijk DF, Stroes ESG, Kastelein JJP, Lipid measures and cardiovascular disease prediction. DIS MARKERS 2009;26 (5-6):209-216 [PubMed]
van Zaane B, Reuwer AQ, Büller HR, Kastelein JJP, Gerdes VEA, Twickler MTB, Hormones and Cardiovascular Disease: A Shift in Paradigm with Clinical Consequences?. SEMIN THROMB HEMOST 2009;35 (5):478-487 [PubMed]
Wijbrandts CA, van Leuven SI, Boom HD, Gerlag DM, Stroes EGS, Kastelein JJP, Tak PP, Sustained changes in lipid profile and macrophage migration inhibitory factor levels after anti-tumour necrosis factor therapy in rheumatoid arthritis. ANN RHEUM DIS 2009;68 (8):1316-1321 [PubMed]
Akdim F, de Groot E, Kastelein JJP, Simvastatin with or without ezetimibe in familial hypercholesterolemia - Reply. NEW ENGL J MED 2008;359 (5):532
Akdim F, Kastelein JJP, Gaudet D, The ENHANCE study and marketing ezetimibe. JAMA-J AM MED ASSOC 2008;299 (23):2747-2747; author reply 2748 [PubMed]
Birjmohun RS. HDL on the crossroads of inflammation, coagulation and atherosclerosis. s.l.: s.n.; 2008. 284p. ISBN 97890909023077 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Stroes ESG)
Birjmohun RS, Hovingh GK, Stroes ESG, Hofstra JJ, Dallinga-Thie GM, Meijers JCM, Kastelein JJP, Levi M, Effects of short-term and long-term danazol treatment on lipoproteins, coagulation, and progression of atherosclerosis: two clinical trials in healthy volunteers and patients with hereditary angioedema. CLIN THER 2008;30 (12):2314-2323 [PubMed]
Boekholdt SM, de Winter RJ, Kastelein JJP, Inhibition of lipoprotein-associated phospholipase activity by darapladib: shifting gears in cardiovascular drug development: are antiinflammatory drugs the next frontier?. CIRCULATION 2008;118 (11):1120-1122 [PubMed]
Bouhali T, Brisson D, St-Pierre J, Tremblay G, Perron P, Laprise C, Vohl MC, Vissers MN, Hutten BA, Després JP, Kastelein JJP, Gaudet D, Low plasma adiponectin exacerbates the risk of premature coronary artery disease in familial hypercholesterolemia. ATHEROSCLEROSIS 2008;196 (1):262-269 [PubMed]
Brunham LR, Kastelein JJP, Hayden MR, ABCA1 Gene Mutations, HDL Cholesterol Levels, and Risk of Ischemic Heart Disease. JAMA-J AM MED ASSOC 2008;300 (17):1997-1998 [PubMed]
de Groot E, van Leuven SI, Duivenvoorden R, Meuwese MC, Akdim F, Bots ML, Kastelein JJ, Measurement of carotid intima-media thickness to assess progression and regression of atherosclerosis. NAT CLIN PRACT CARD 2008;5 (5):280-288 [PubMed]
Dorfmeister B, Zeng WW, Dichlberger A, Nilsson SK, Schaap FG, Hubacek JA, Merkel M, Cooper JA, Lookene A, Putt W, Whittall R, Lee PJ, Lins L, Delsaux N, Nierman M, Kuivenhoven JA, Kastelein JJP, Vrablik M, Olivecrona G, Schneider WJ, Heeren J, Humphries SE, Talmud PJ, Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding. ARTERIOSCL THROM VAS 2008;28 (10):1866-1871 [PubMed]
El Harchaoui K, Akdim F, Stroes ESG, Trip MD, Kastelein JJP, Current and future pharmacologic options for the management of patients unable to achieve low-density lipoprotein-cholesterol goals with statins. AM J CARDIOVASC DRUG 2008;8 (4):233-242 [PubMed]
Franssen R, Monajemi H, Stroes ESG, Kastelein JJP, Obesity and Dyslipidemia. ENDOCRIN METAB CLIN 2008;37 (3):623-+ [PubMed]
Franssen R, Visser ME, Kuivenhoven JA, Kastelein JJP, Dallinga-Thie GM, Stroes ESG, Role of lipoprotein lipase in triglyceride metabolism: potential therapeutic target. FUTURE LIPIDOL 2008;3 (4):385-397
Holleboom AG, Vergeer M, Hovingh GK, Kastelein JJ, Kuivenhoven JA, The value of HDL genetics. CURR OPIN LIPIDOL 2008;19 (4):385-394 [PubMed]
Holme I, Cater NB, Faergeman O, Kastelein JJP, Olsson AG, Tikkanen MJ, Larsen ML, Lindahl C, Pedersen TR, Lipoprotein predictors of cardiovascular events in statin-treated patients with coronary heart disease. insights from the incremental decrease in end-points through aggressive lipid-lowering trial (IDEAL). ANN MED 2008;40 (6):456-464 [PubMed]
Homsma SJM, Huijgen R, Middeldorp S, Sijbrands EJG, Kastelein JJP, Molecular screening for familial hypercholesterolaemia: consequences for life and disability insurance. EUR J HUM GENET 2008;16 (1):14-17 [PubMed]
Homsma SJM, Huijgen R, Middeldorp S, Sijbrands EJG, Kastelein JJP, Molecular screening for familial hypercholesterolaemia: consequences for life and disability insurance [Corrigendum]. EUR J HUM GENET 2008;16 (2):275 [PubMed]
Huijgen R, Vissers MN, Defesche JC, Lansberg PJ, Kastelein JJP, Hutten BA, Familial hypercholesterolemia: current treatment and advances in management. EXPERT REV CARDIOVASC THER 2008;6 (4):567-581 [PubMed]
Kastelein JJP, Akdim F, Stroes ESG, Zwinderman AH, Bots ML, Stalenhoef AFH, Visseren FLJ, Sijbrands EJG, Trip MD, Stein EA, Gaudet D, Duivenvoorden R, Veltri EP, Marais AD, de Groot E, Simvastatin with or without ezetimibe in familial hypercholesterolemia. NEW ENGL J MED 2008;358 (14):1431-1443 [PubMed]
Kastelein JJP, Akdim F, Stroes ESG, Zwinderman AH, Bots ML, Stalenhoef AFH, Visseren FLJ, Sijbrands EJG, Trip MD, Stein EA, Gaudet D, Duivenvoorden R, Veltri EP, Marais AD, de Groot E, Simvastatin with or without ezetimibe in familial hypercholesterolemia (vol 358, pg 1431, 2008). NEW ENGL J MED 2008;358 (18):1977
Kastelein JJP, de Groot E, Ultrasound imaging techniques for the evaluation of cardiovascular therapies. EUR HEART J 2008;29 (7):849-858 [PubMed]
Kastelein JJP, van der Steeg WA, Holme I, Gaffney M, Cater NB, Barter P, Deedwania P, Olsson AG, Boekholdt SM, Demicco DA, Szarek M, LaRosa JC, Pedersen TR, Grundy SM, Lipids, apolipoproteins, and their ratios in relation to cardiovascular events with statin treatment. CIRCULATION 2008;117 (23):3002-3009 [PubMed]
Koeijvoets KCMC, van der Net JB, van Rossum EFC, Steyerberg EW, Defesche JC, Kastelein JJP, Lamberts SWJ, Sijbrands EJG, Two Common Haplotypes of the Glucocorticoid Receptor Gene Are Associated with Increased Susceptibility to Cardiovascular Disease in Men with Familial Hypercholesterolemia. J CLIN ENDOCR METAB 2008;93 (12):4902-4908 [PubMed]
Meuwese MC. Targeting the vessel wall in cardiovascular prevention. s.l.: s.n.; 2008. 262p. ISBN 9789085594024 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Stroes ESG, Vink H)
Meuwese MC, Trip MD, van Wissen S, van Miert JNI, Kastelein JJP, Stroes ESG, Myeloperoxidase levels are not associated with carotid atherosclerosis progression in patients with familial hypercholesterolemia. ATHEROSCLEROSIS 2008;197 (2):916-921 [PubMed]
Nieuwdorp M, Meuwese MC, Mooij HL, Ince C, Broekhuizen LN, Kastelein JJP, Stroes ESG, Vink H, Measuring endothelial glycocalyx dimensions in humans: a potential novel tool to monitor vascular vulnerability. J APPL PHYSIOL 2008;104 (3):845-852 [PubMed]
Nieuwdorp M, Vergeer M, Bisoendial RJ, Op 't Roodt J, Levels H, Birjmohun RS, Kuivenhoven JA, Basser R, Rabelink TJ, Kastelein JJP, Stroes ESG, Reconstituted HDL infusion restores endothelial function in patients with type 2 diabetes mellitus. DIABETOLOGIA 2008;51 (6):1081-1084 [PubMed]
Nissen SE, Nicholls SJ, Wolski K, Rodes-Cabau J, Cannon CP, Deanfield JE, Despres JP, Kastelein JJP, Steinhubl SR, Kapadia S, Yasin M, Ruzyllo W, Gaudin C, Job B, Hu B, Bhatt DL, Lincoff AM, Tuzcu EM, Effect of rimonabant on progression of atherosclerosis in patients with abdominal obesity and coronary artery disease - The STRADIVARIUS randomized controlled trial. JAMA-J AM MED ASSOC 2008;299 (13):1547-1560 [PubMed]
Regieli JJ, Jukema JW, Grobbee DE, Kastelein JJP, Kuivenhoven JA, Zwinderman AH, van der Graaf Y, Bots ML, Doevendans PA, CETP genotype predicts increased mortality in statin-treated men with proven cardiovascular disease: an adverse pharmacogenetic interaction. EUR HEART J 2008;29 (22):2792-2799 [PubMed]
Ridker PM, Danielson E, Fonseca FAH, Genest J, Gotto AM Jr, Kastelein JJP, Koenig W, Libby P, Lorenzatti AJ, Macfadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ [Contributors: Ridker PM, Fonseca FAH, Genest J, Gotto AM Jr, Kastelein JJP, Koenig W, Libby P, Lorenzatti AJ, Nordestgaard BG, Shepherd J, Willerson JT, Danielson E, Glynn RJ, MacFadyen JG, Mora S, Collins R, Bailey K, Gersh B, Lamas G, Smith S, Vaughan D, Mahaffey K, Brown P, Montgomery D, Wilson M, Wood F, Altamirano J, Boskis P, Colombo H, Cuneo C, Diaz M, Esper R, Fernandez A, Foye R, Hershson A, Kuschnir E, La Greca R, Lorenzatti A, Lozada A, Luciardi H, Luquez H, Maffei L, Majul C, Marin M, Muntaner J, Nul D, Paolasso E, Rey R, Rodenas P, Rodriguez P, Rojas C, Telsolin P, Vita N, Adrianes G, Argento O, Bacart P, Baeck L, Baguet J, Balthazar Y, Battello G, Behets J, Beke P, Berwouts P, Boermans P, Bolly F, Borms J, Boulad M, Boulanger L, Bous J, van Boxstael R, Brands Y, Buyse L, Calozet Y, Camps K, Capiau L, Celis H, Coucke F, D'Argent F, Op de Beeck G, de Meulemeester M, de Praeter K, de Rouck S, Delcourt A, Delvaux J, Demanet E, Dendale P, Derijcke M, Deruyck C, Devaux J, Dupont C, van Duyse J, Erpicum L, Gilio C, Gillet A, Grosjean J, Heeren J, Henry G, Heyvaert F, Hollanders G, Hutsebaut A, Janssens P, Lannoy H, Ledoux C, Legros P, Leliaert R, Martens R, Maury O, Mehuys G, Michaux J, Migeotte A, Mortelmans J, van Mulders N, van Parijs P, van Peer W, Pieters E, Reynders P, van Riet D, Robert P, van Stee J, Teheux J, Teuwen J, Thoeng J, Timmermans B, Tshinkulu M, Vanden Bemden S, Vantroyen D, Veevaete M, Vercruysse K, Vereecken G, Vermeersch L, Vernijns J, Verspecht E, Vinck G, Vrancken F, Watté G, Weymans J, Windmolders S, Albuquerque DC, Barbosa ECD, Bertolami MC, Blacher C, Brasileiro ALS, Costa e Forti A, Eliaschewitz FG, Esteves JP, Feitosa GS, Francischetti EA, Franco RJS, Gomes MA, Gross JL, Jardim PC, Kohlmann O Jr, Loures-Vale AA, Magalhães MEC, Maia LN, Moriguchi EH, Nogueira PR, Oigman W, Repetto G, Santos RD, Saraiva JFK, Xavier HT, Benov H, Chompalova B, Donova T, Gocheva N, Goudev A, Grigorov M, Gruev T, Hergeldjieva V, Marchev S, Mihov A, Pasheva V, Penev A, Popov A, Raev D, Sirakova V, Slavcheva A, Stoikov A, Stoilov R, Tisheva S, Todorov G, Torbova S, Uzunangelov J, Achyuthan G, Akhras R, Barriere G, Bartlett J, Behiels S, Bell A, Bergeron J, Berlingieri J, Bhamjee H, Bodok-Nutzati R, Booth W, Boyd C, Brault S, Bruckswaiger D, Bukovy B, Campbell G, Carlson B, Cha J, Chehayeb R, Cheng W, Chilvers M, Chouinard G, Chow W, Conter H, Conway J, Craig B, Craig D, Dattani I, del Grande R, Dharamshi S, Dickson M, Dion D, Dowell A, Drexler J, Dube S, Dupont A, Dworkin B, Fields L, Filteau P, Gardiner E, Gervais B, Gillis G, Girard R, Goldman H, Gorfinkel I, Goulet S, Greenspoon A, Gritter R, Gupta A, Gupta M, Habib N, Harding R, Hart R, Henein S, Henry D, Hirsch A, Ho K, Hoag G, Houde D, Howlett E, Ing G, Jadd J, Janes J, Jardine F, Johnston T, Kanani S, Kazimirski M, Kelly A, Klajner F, Kooy J, Lalani A, Lam S, Laranjeiro J, LaRose D, Leiter L, Leung W, Li J, Lowe D, Luces K, Ma P, MacKinnon R, Martinho V, Matangi M, McCrossin M, McIsaac H, McMullen W, Mehta P, Meunier M, Misik K, Nayar A, Ng A, Nigro F, Noronha L, O'Mahony W, Pandey S, Papp E, Patel V, Patrick L, Peddle C, Pinsky N, Poirier P, Powell C, Price J, Rolfe A, Saliba N, Sawkiw R, Senior R, Shu D, Smith R, Somani R, Soowamber M, Stakiw K, Talbot P, Taliano J, Tan K, Teitelbaum I, Threoux P, Tremblay G, Turcotte C, Tytus R, Walsh P, Webb G, Willoughby P, Woo V, Woodland R, Yee G, Acevedo M, Caorsi C, Cardenas N, Gonzalez B, Gutierrez M, Prieto J, Stockins B, Valerta P, Vejar M, Ardila W, Aschner P, Botero J, Botero R, Calderon C, Casas L, Castellanos R, Cure C, Escobar I, Fortich A, Garcia L, Hernandez E, Isaza D, Jaramillo N, Jiménez C, Kattah W, Luengas C, Matiz C, Perez M, Quintero A, Rizcala A, Ruiz A, Urina M, Valenzuela A, Cob-Sanchez A, Gutreiman-Golberg M, Lainez-Ventosilla A, Ramirez-Zamora L, Slon-Hitti C, Speranza-Sánchez M, Vinocour-Fornieri M, Hansen H, Nordestgaard B, Steffensen R, Stender S, Alvarado-Renderos J, Rivera-Ochoa L, Villarroel-Abrego H, Eha J, Jaanson E, Kaasik U, Keba E, Mäeots E, Petersen M, Reinmets S, Roostalu U, Vahula V, Veidrik K, Bellmann R, Hanefeld M, Horacek T, Klein C, Knels R, Laus S, Meissner G, Mondrof C, Schell E, Schuster H, Sehnert W, Stahl H, Szelazek G, Winkelmann B, Witczak E, Elis A, Gavish A, Grossman E, Harats D, Keidar S, Levy Y, Osamah H, Shapiro I, Shveydel E, Wolfovitz E, Yogev R, Zeltser D, Arenas JL, Cardona-Muñoz E, Cervantes JL, Flores-Lozano F, Gonzalez C, Gonzalez-Galvez G, Gonzalez JG, Gutierrez-Fajardo P, Morales E, de los Rios M, Romero-Zazueta A, Talavera JO, Velasco-Sanchez R, Vergara-Takahashi H, Zúñiga-Guajardo S, Agous I, Bak A, Bartels G, Basart D, Cornel J, de Schipper L, Holwerda N, Jonker J, Köse V, Lok D, Lokhorst B, Mosterd A, Nierop P, Oude Ophuis A, Somer S, Tiebesl J, Trip M, van Hessen M, van Kempen W, Andersen M, Berz A, Bjurstrom M, Bo P, Brunstad O, Daae-Johansen T, Elle S, Fauske J, Fossdal B, Gjefsen O, Hallaraker A, Haugen J, Helberg S, Holm-Johnsen S, Istad H, Jacobsen T, Johansen R, Jorstad T, Jorum I, Kjorlaug K, Kontny F, Langaker K, Larsen B, Lonning S, Loraas A, Mansilla-Tinoco R, Medhus R, Meyer I, Nasrala S, Ofjord E, Ose L, Palmas J, Risberg K, Sandberg A, Sirnes P, Skjegstad E, Skjelvan G, Solnor L, Storm-Larsen A, Tandberg A, Tomala T, Torkelsen A, Ursin A, Valnes K, Walaas K, Binns-Halman R, Delgado-Paredes A, Lombana-Vasquez B, Noriega-Aguirre L, Trujillo-Sagel R, Kowalczyk-Kram M, Artemiuk E, Asankowicz-Bargiel B, Banas I, Baranska E, Baranski M, Bijata-Bronisz R, Sikorska A, Blaszczyk B, Bolanowski J, Brokl-Stolarczyk B, Brzecki K, Buczkowski K, Chmielewski T, Chojnowska-Jezierska J, Chwist-Novak A, Cygan W, Czajkowska-Kaczmarek E, Dargiewicz A, Dluzniewski M, Dudka C, Fares I, Flasinska J, Gadzinski W, Gaszczyk G, Golebiowski G, Gozdur W, Grudzien K, Sobieska E, Kalamarz J, Kalinowska A, Kornacewicz-Jach Z, Korol M, Korycka W, Kostka T, Kostrzewska A, Kot A, Kowalska-Werbowy B, Krupinska G, Lotocka E, Luberda-Heynar Z, Lukas W, Lysek R, Machyna-Dybala A, Mlynarczyk-Jeremicz K, Mocarska-Gorna B, Niedbal-Yahfouf I, Pasternak D, Potakowska I, Ramian U, Roleder M, Rosinska-Migda J, Sidorowicz-Bialynicka A, Skierkowska J, Skorinko I, Slaboszewska J, Sleziak-Barglik K, Stachlewski P, Superson-Byra E, Tissler-Nahorska G, Turbak R, Uzunow A, Wasowicz D, Wodniecki J, Wojnowski L, Wrzol A, Zdrojewska J, Zurakowska-Krzywonos A, Zurowska-Gebala M, Ablachim T, Abobului M, Balanescu S, Bobescu E, Bojinca M, Cristea M, Gaita D, Stoicovici R, Tataru R, Tudose A, Ardashev V, Arutyunov G, Azarin O, Barbarash O, Bondarev S, Borisov M, Boyarkin M, Burova N, Chazova I, Dovgalevsky P, Duplyakov D, Egorova L, Goloshchekin B, Gratsianskiy N, Ivleva A, Karpov R, Karpov YA, Karpov YB, Khokhlov A, Khokhlov R, Khrustalev O, Konyakhin A, Kostenko V, Libov I, Lukyanov Y, Mezentseva N, Panov A, Repin M, Shabalin A, Shalaev S, Shilkina N, Shulman V, Sidorenko B, Smolenskaya O, Starodubtsev A, Talibov O, Titkov Y, Tsyba L, Uspenskiy Y, Vishnevsky A, Yarokhno N, Ahmed S, Ashtiker H, Bester A, Bhorat Q, Biermann E, Boyd W, Burgess L, Dindar F, Dulabh R, Engelbrecht I, Erasmus E, Fouche L, Furman S, Govind U, Herbst L, Jacovides A, Kahanovitz C, Kruger C, Lakha D, Lombaard J, Macleod A, Makan H, Manuel E, McDonald M, Mitha E, Mitha I, Moola S, Nell H, Nieuwoudt G, Olivier P, Padayachee T, Pillai P, Pillay S, Ranjith N, Reyneke S, Sandell R, Sandell P, Sebastian P, Skriker M, Smit J, van Rensburg D, van Zyl L, Vawda Z, Wellman H, Miserez A, Adbulhakim E, Angus M, Balmer F, Balmer J, Barrat R, Blair D, Blyth A, Brodie R, Brydie D, Campbell C, Campbell I, Church M, Clark C, Clements R, Donnachie AN, Fitpatrick P, Godley C, Hill J, Jarvie F, Kieran W, Langridge S, Leslie R, Liddell A, MacKenzie J, MacKintosh C, Mair R, 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L, Taghizadeh B, Tague R, Tambunan D, Tannoury G, Tavaez Valle J, Thieneman A, Thigpen D, Thompson P, Tidman R, Tilton G, Tokatlian E, Topkis R, Torelli M, Tortorice F, Toth P, Touger M, Treat S, Trevino M, Trupin S, Turner A, Turner M, Tweel C, Ugarte J, Ulmer E, Urbach D, Vacker M, Vallecillo J, van de Beek M, Vargas L, Vazquez Tanus J, Verma A, Vijayaraghavan K, Wade P, Wade T, Wagner S, Wahle J, Walker J, Walker M, Weinstein R, Weisbrot A, Weiss R, West P, White A, Wickemeyer W, Wieskopf B, Wiggins M, Williams H, Wiseman J, Yataco A, Yates S, Zamarra J, Zamora B, Zawada E, Zemel L, Zigrang W, Zusman R, Aguiton M, Arroyo-Parejo M, Beaujon Sierralta J, Berrizbeitia M, Carrizales de Marlin Y, Colan Parraga J, Fernandez C, Fuenmayor N, Giesen G, Gonzalez Gomez C, Guaipo A, Herrera Rivera C, Jaua L, Lopez N, Lopez Nouel R, Marulanda M, Morr I, Nass A, Palmucci G, Perez L, Ponte C, Rivas I, de Roa E, Figarella Salazar G, Sanchez F, Siriti U, Viloria A]] , Rosuvastatin to prevent vascular 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Sagoo GS, Tatt I, Salanti G, Butterworth AS, Sarwar N, van Maarle M, Jukema JW, Wiman B, Kastelein JJP, Bennet AM, de Faire U, Danesh J, Higgins JPT, Seven Lipoprotein Lipase Gene Polymorphisms, Lipid Fractions, and Coronary Disease: A HuGE Association Review and Meta-Analysis. AM J EPIDEMIOL 2008;168 (11):1233-1246 [PubMed]
Sankatsing RR. Atherosclerosis in the HIV and Non-HIV setting: detecting and modifying cardiovascular risk. s.l.: s.n.; 2008. 191p. ISBN 9789071382673 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP, Reiss P; copromotor(s): Stroes ESG)
Shah SJ, Waters DD, Barter P, Kastelein JJP, Shepherd J, Wenger NK, Demicco DA, Breazna A, LaRosa JC, Intensive lipid-lowering with atorvastatin for secondary prevention in patients after coronary artery bypass surgery. J AM COLL CARDIOL 2008;51 (20):1938-1943 [PubMed]
Shepherd J, Kastelein JJP, Bittner V, Deedwania P, Breazna A, Dobson S, Wilson DJ, Zuckerman A, Wenger NK, Intensive lipid lowering with atorvastatin in patients with coronary heart disease and chronic kidney disease. J AM COLL CARDIOL 2008;51 (15):1448-1454 [PubMed]
Shepherd J, Kastelein JP, Bittner VA, Carmena R, Deedwania PC, Breazna A, Dobson S, Wilson DJ, Zuckerman AL, Wenger NK, Intensive lipid lowering with atorvastatin in patients with coronary artery disease, diabetes, and chronic kidney disease. MAYO CLIN PROC 2008;83 (8):870-879 [PubMed]
Stroes ES, Nierman MC, Meulenberg JJ, Franssen R, Twisk J, Henny CP, Maas MM, Zwinderman AH, Ross C, Aronica E, High KA, Levi MM, Hayden MR, Kastelein JJ, Kuivenhoven JA, Intramuscular Administration of AAV1-Lipoprotein Lipase(S447X) Lowers Triglycerides in Lipoprotein Lipase-Deficient Patients. ARTERIOSCL THROM VAS 2008;28 (12):2303-U264 [PubMed]
van Acker BAC, Botma GJ, Zwinderman AH, Kuivenhoven JA, Dallinga-Thie GM, Sijbrands EJG, Boer JMA, Seidell JC, Jukema JW, Kastelein JJP, Jansen H, Verhoeven AJM, High HDL cholesterol does not protect against coronary artery disease when associated with combined cholesteryl ester transfer protein and hepatic lipase gene variants. ATHEROSCLEROSIS 2008;200 (1):161-167 [PubMed]
van der Graaf A, Cuffie-Jackson C, Vissers MN, Trip MD, Gagné C, Shi G, Veltri E, Avis HJ, Kastelein JJP, Efficacy and Safety of Coadministration of Ezetimibe and Simvastatin in Adolescents With Heterozygous Familial Hypercholesterolemia. J AM COLL CARDIOL 2008;52 (17):1421-1429 [PubMed]
van der Graaf A, Rodenburg J, Vissers MN, Hutten BA, Wiegman A, Trip MD, Stroes ESG, Wijburg FA, Otvos JD, Kastelein JJP, Atherogenic lipoprotein particle size and concentrations and the effect of pravastatin in children with familial hypercholesterolemia. J PEDIATR-US 2008;152 (6):873-878 [PubMed]
van der Graaf A, Touchier SW, Vissers MN, Defesche JC, Wiegman A, Sankatsing RR, Hutten BA, Trip MD, Kastelein JJP, Familial defective apolipoprotein B and familial hypobetalipoproteinemia in one family: Two neutralizing mutations. ANN INTERN MED 2008;148 (9):712-714 [PubMed]
van der Net JB, Isaacs A, Dallinga-Thie GM, Kastelein JJP, Defesche JC, Steyerberg EW, Sijbrands EJG, Haplotype of the angiotensinogen gene is associated with coronary heart disease in familial hypercholesterolemia. J HYPERTENS 2008;26 (3):462-467 [PubMed]
van der Net JB, Janssens ACJW, Eijkemans MJC, Kastelein JJP, Sijbrands EJG, Steyerberg EW, Cox proportional hazards models have more statistical power than logistic regression models in cross-sectional genetic association studies. EUR J HUM GENET 2008;16 (9):1111-1116 [PubMed]
van der Net JB, Oosterveer DM, Versmissen J, Defesche JC, Yazdanpanah M, Aouizerat BE, Steyerberg EW, Malloy MJ, Pullinger CR, Kastelein JJP, Kane JP, Sijbrands EJG, Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia. EUR HEART J 2008;29 (18):2195-2201 [PubMed]
van der Net JB, van Etten J, Yazdanpanah M, Dallinga-Thie GM, Kastelein JJP, Defesche JC, Koopmans RP, Steyerberg EW, Sijbrands EJG, Gene-load score of the renin-angiotensin-aldosterone system is associated with coronary heart disease in familial hypercholesterolaemia. EUR HEART J 2008;29 (11):1370-1376 [PubMed]
van der Steeg WA, Holme I, Boekholdt SM, Larsen ML, Lindahl C, Stroes ESG, Tikkanen MJ, Wareham NJ, Faergeman O, Olsson AG, Pedersen TR, Khaw KT, Kastelein JJP, High-density lipoprotein cholesterol, high-density lipoprotein particle size, and apolipoprotein A-I: Significance for cardiovascular risk - The IDEAL and EPIC-Norfolk studies. J AM COLL CARDIOL 2008;51 (6):634-642 [PubMed]
van Leuven SI, Franssen R, Kastelein JJ, Levi M, Stroes ESG, Tak PP, Systemic inflammation as a risk factor for atherothrombosis. RHEUMATOLOGY 2008;47 (1):3-7 [PubMed]
van Leuven SI, Stroes ES, Kastelein JJP, High-density lipoprotein: A fall from grace?. ANN MED 2008;40 (8):584-593 [PubMed]
Vergeer M, Bots ML, van Leuven SI, Basart DC, Sijbrands EJ, Evans GW, Grobbee DE, Visseren FL, Stalenhoef AF, Stroes ES, Kastelein JJP, Cholesteryl Ester Transfer Protein Inhibitor Torcetrapib and Off-Target Toxicity A Pooled Analysis of the Rating Atherosclerotic Disease Change by Imaging With a New CETP Inhibitor (RADIANCE) Trials. CIRCULATION 2008;118 (24):2515-2522 [PubMed]
Vergeer M, Kastelein JJP, Anacetrapib: new hope for cholesteryl ester transfer protein inhibitors in the treatment of dyslipidemia. NAT CLIN PRACT CARD 2008;5 (6):302-303 [PubMed]
Versmissen J, Oosterveer DM, Yazdanpanah M, Defesche JC, Basart DCG, Liem AH, Heeringa J, Witteman JC, Lansberg PJ, Kastelein JJP, Sijbrands EJG, Efficacy of statins in familial hypercholesterolaemia: a long term cohort study. BMJ-BRIT MED J 2008;337:a2423 [PubMed]
Visser ME, Jakulj L, Kastelein JJP, Stroes ESG, LDL-C-lowering therapy: current and future therapeutic targets. CURR CARDIOL REP 2008;10 (6):512-520 [PubMed]
Vissers MN, Trip MD, Pritchard PH, Tam P, Lukic T, de Sain-van der Velden MG, de Barse M, Kastelein JJP, Efficacy and safety of disodium ascorbyl phytostanol phosphates in men with moderate dyslipidemia. EUR J CLIN PHARMACOL 2008;64 (7):651-661 [PubMed]
Wright CI, Scholten HJ, Schilder JCM, Elsen BM, Hanselaar W, Kroner CI, Draijer R, Kastelein JJP, Stok W, Karemaker J, de Groot E, Arterial stiffness, endothelial function and microcirculatory reactivity in healthy young males. CLIN PHYSIOL FUNCT I 2008;28 (5):299-306 [PubMed]
Akdim F, El Harchaoui K, Stroes ESG, Kastelein JJP, Antisense apolipoprotein B-100 as novel treatment for hypercholesterolemia: focus on ISIS 301012. FUTURE LIPIDOL 2007;2 (4):387-393
Akdim F, Stroes ESG, Kastelein JJP, Antisense apolipoprotein B therapy: where do we stand?. CURR OPIN LIPIDOL 2007;18 (4):397-400 [PubMed]
Akdim F, van Leuven SI, Kastelein JJP, Stroes ESG, Pleiotropic effects of statins: stabilization of the vulnerable atherosclerotic plaque?. CURR PHARM DESIGN 2007;13 (10):1003-1012 [PubMed]
Arsenault BJ, Lemieux I, Després JP, Wareham NJ, Luben R, Kastelein JJP, Khaw KT, Boekholdt SM, Cholesterol levels in small LDL particles predict the risk of coronary heart disease in the EPIC-Norfolk prospective population study. EUR HEART J 2007;28 (22):2770-2777 [PubMed]
Avis HJ, Vissers MN, Stein EA, Wijburg FA, Trip MD, Kastelein JJP, Hutten BA, A systematic review and meta-analysis of statin therapy in children with familial hypercholesterolemia. ARTERIOSCL THROM VAS 2007;27 (8):1803-1810 [PubMed]
Barter P, Gotto AM, LaRosa JC, Maroni J, Szarek M, Grundy SM, Kastelein JJP, Bittner V, Fruchart JC, HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events. NEW ENGL J MED 2007;357 (13):1301-1310 [PubMed]
Barter PJ, Caulfield M, Eriksson M, Grundy SM, Kastelein JJP, Komajda M, Lopez-Sendon J, Mosca L, Tardif JC, Waters DD, Shear CL, Revkin JH, Buhr KA, Fisher MR, Tall AR, Brewer B, Effects of torcetrapib in patients at high risk for coronary events. NEW ENGL J MED 2007;357 (21):2109-2122 [PubMed]
Birjmohun RS, Bisoendial RJ, van Leuven SI, Ackermans M, Zwinderman A, Kastelein JJP, Stroes ESG, Sauerwein HP, A single bolus infusion of C-reactive protein increases gluconeogenesis and plasma glucose concentration in humans. METABOLISM 2007;56 (11):1576-1582 [PubMed]
Birjmohun RS, Dallinga-Thie GM, Kuivenhoven JA, Stroes ESG, Otvos JD, Wareham NJ, Luben R, Kastelein JJP, Khaw KT, Boekholdt SM, Apolipoprotein A-II is inversely associated with risk of future coronary artery disease. CIRCULATION 2007;116 (18):2029-2035 [PubMed]
Birjmohun RS, Kastelein JJP, Poldermans D, Stroes ESG, Hostalek U, Assmann G, Safety and tolerability of prolonged-release nicotinic acid in statin-treated patients. CURR MED RES OPIN 2007;23 (7):1707-1713 [PubMed]
Birjmohun RS, Stroes ESG, Kastelein JJP, Raising high-density lipoprotein cholesterol for better prevention of cardiovascular disease. FUTURE LIPIDOL 2007;1 (1):47-54
Birjmohun RS, van Leuven SI, Levels JHM, van 't Veer C, Kuivenhoven JA, Meijers JCM, Levi M, Kastelein JJP, van der Poll T, Stroes ESG, High-density lipoprotein attenuates inflammation and coagulation response on endotoxin challenge in humans. ARTERIOSCL THROM VAS 2007;27 (5):1153-1158 [PubMed]
Bisoendial RJ, Kastelein JJP, Peters SLM, Levels JHM, Birjmohun R, Rotmans JI, Hartman D, Meijers JCM, Levi M, Stroes ESG, Effects of CRP infusion on endothelial function and coagulation in normocholesterolemic and hypercholesterolemic subjects. J LIPID RES 2007;48 (4):952-960 [PubMed]
Bisoendial RJ, Kastelein JJP, Stroes ESG, C-reactive protein and atherogenesis: from fatty streak to clinical event. ATHEROSCLEROSIS 2007;195 (2):e10-e18 [PubMed]
Bots ML, Baldassarre D, Simon A, de Groot E, O'Leary DH, Riley W, Kastelein JJ, Grobbee DE, Carotid intima-media thickness and coronary atherosclerosis: weak or strong relations?. EUR HEART J 2007;28 (4):398-406 [PubMed]
Bots ML, Visseren FL, Evans GW, Riley WA, Revkin JH, Tegeler CH, Shear CL, Duggan WT, Vicari RM, Grobbee DE, Kastelein JJ, Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial. LANCET 2007;370 (9582):153-160 [PubMed]
Bredie SJH, Stroes ESG, Kastelein JJP, Jukema JW. Van lipidenmetabolisme naar behandeling in: van der Wall EE, Van de Werf F, Zijlstra F, editors. Cardiologie. Houten: Bohn Stafleu van Loghum; 2008. 2de herziene druk, p. 23-32
Büller HR, Kastelein JJP, Stroes ESG, editors, Vasculaire Geneeskunde, 3e herziene druk. Alphen aan de Rijn: Van Zuiden Communications; 2007. 405p. ISBN 978-90-8523-151-6
Duivenvoorden R, Kastelein JJP, de Groot E. Imaging modalities as tools for the investigation of atherosclerosis and atherosclerotic disease in: Assmann G, editors. International Cardiovascular Prevention Task Force. Münster, Duitsland: s.n.; 2007., p. -
Duivenvoorden R, Nederveen AJ, de Groot E, Kastelein JJP, Atherosclerosis imaging as a benchmark in the development of novel cardiovasular drugs. CURR OPIN LIPIDOL 2007;18 (6):613-621 [PubMed]
El Harchaoui K, van der Steeg WA, Stroes ESG, Kastelein JJP, The role of CETP inhibition in dyslipidemia. CURR ATHEROSCLER REP 2007;9 (2):125-133 [PubMed]
El Harchaoui K, van der Steeg WA, Stroes ESG, Kuivenhoven JA, Otvos JD, Wareham NJ, Hutten BA, Kastelein JJP, Khaw KT, Boekholdt SM, Value of low-density lipoprotein particle number and size as predictors of coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study. J AM COLL CARDIOL 2007;49 (5):547-553 [PubMed]
Kastelein JJP, Refocusing on use of cholesteryl ester transfer protein inhibitors. AM J CARDIOL 2007;100 (11 A):n47-n52 [PubMed]
Kastelein JJP, van Leuven SI, Burgess L, Evans GW, Kuivenhoven JA, Barter PJ, Revkin JH, Grobbee DE, Riley WA, Shear CL, Duggan WT, Bots ML, Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia. NEW ENGL J MED 2007;356 (16):1620-1630 [PubMed]
Kastelein JJP, van Leuven SI, Evans GW, Riley WA, Revkin JH, Shear CL, Bots ML, Designs of RADIANCE 1 and 2: carotid ultrasound studies comparing the effects of torcetrapib/atorvastatin with atorvastatin alone on atherosclerosis. CURR MED RES OPIN 2007;23 (4):885-894 [PubMed]
Khush KK, Waters DD, Bittner V, Deedwania PC, Kastelein JJP, Lewis SJ, Wenger NK, Effect of high-dose atorvastatin on hospitalizations for heart failure: subgroup analysis of the Treating to New Targets (TNT) study. CIRCULATION 2007;115 (5):576-583 [PubMed]
LaRosa JC, Grundy SM, Kastelein JJP, Kostis JB, Greten H, Safety and efficacy of atorvastatin-induced very low-density lipoprotein cholesterol levels in patients with coronary heart disease (a post hoc analysis of the treating to new targets [TNT] study). AM J CARDIOL 2007;100 (5):747-752 [PubMed]
Meuwese MC, Stroes ESG, Hazen SL, van Miert JN, Kuivenhoven JA, Schaub RG, Wareham NJ, Luben R, Kastelein JJP, Khaw KT, Boekholdt SM, Serum Myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals - The EPIC-Norfolk prospective population study. J AM COLL CARDIOL 2007;50 (2):159-165 [PubMed]
Nierman MC, Rip J, Kuivenhoven JA, Sakai N, Kastelein JJP, de Sain-van der Velden MGM, Stroes ESG, Prinsen BHCMT, Enhanced apoB48 metabolism in lipoprotein lipase X447 homozygotes. ATHEROSCLEROSIS 2007;194 (2):446-451 [PubMed]
Nieuwdorp M. Metabolic and vascular dysfunction during hyperglycemia induced inflammation. The role of the endothelial glycocalyx on vascular homeostasis in vivo. s.l.: s.n.; 2007. 158p. ISBN 9789090221038 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Hoekstra JBL, Kastelein JJP; copromotor(s): Stroes ESG, Vink H)
Nieuwdorp M, Holleman F, de Groot E, Vink H, Gort J, Kontush A, Chapman MJ, Hutten BA, Brouwer CB, Hoekstra JBL, Kastelein JJP, Stroes ESG, Perturbation of hyaluronan metabolism predisposes patients with type 1 diabetes mellitus to atherosclerosis. DIABETOLOGIA 2007;50 (6):1288-1293 [PubMed]
Nieuwdorp M, Stroes ESG, Kastelein JJP, Normalization of metabolic syndrome using fenofibrate, metformin or their combination. DIABETES OBES METAB 2007;9 (6):869-878 [PubMed]
Ozsoy RC. The dyslipidemia of chronic renal failure and the effects of statin therapy. s.l.: s.n.; 2007. 160p. ISBN 9789090217475 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Arisz L, Kastelein JJP; copromotor(s): Koopman MG)
Ozsoy RC, van der Steeg WA, Kastelein JJP, Arisz L, Koopman MG, Dyslipidaemia as predictor of progressive renal failure and the impact of treatment with atorvastatin. NEPHROL DIAL TRANSPL 2007;22 (6):1578-1586 [PubMed]
Penning-van Beest FJA, Termorshuizen F, Goettsch WG, Klungel OH, Kastelein JJP, Herings RMC, Adherence to evidence-based statin guidelines reduces the risk of hospitalizations for acute myocardial infarction by 40%: a cohort study. EUR HEART J 2007;28 (2):154-159 [PubMed]
Pinedo S, Vissers MN, von Bergmann K, Elharchaoui K, Lütjohann D, Luben R, Wareham NJ, Kastelein JJP, Khaw KT, Boekholdt SM, Plasma levels of plant sterols and the risk of coronary artery disease: the prospective EPIC-Norfolk Population Study. J LIPID RES 2007;48 (1):139-144 [PubMed]
Rana JS, Boekholdt SM, Ridker PM, Jukema JW, Luben R, Bingham SA, Day NE, Wareham NJ, Kastelein JJP, Khaw KT, Differential leucocyte count and the risk of future coronary artery disease in healthy men and women: the EPIC-Norfolk Prospective Population Study. J INTERN MED 2007;262 (6):678-689 [PubMed]
Rana JS, Nieuwdorp M, Jukema JW, Kastelein JJP, Cardiovascular metabolic syndrome - an interplay of, obesity, inflammation, diabetes and coronary heart disease. DIABETES OBES METAB 2007;9 (3):218-232 [PubMed]
Ridker PM, Fonseca FAH, Genest J, Gotto AM, Kastelein JJP, Khurmi NS, Koenig W, Libby P, Lorenzatti AJ, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ, Baseline characteristics of participants in the JUPITER trial, a randomized placebo-controlled primary prevention trial of statin therapy among individuals with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein. AM J CARDIOL 2007;100 (11):1659-1664 [PubMed]
Rip J, Sierts JA, Vaessen SFC, Kastelein JJP, Twisk J, Kuivenhoven JA, Adeno-associated virus LPL(S447X) gene therapy in LDL receptor knockout mice. ATHEROSCLEROSIS 2007;194 (1):55-61 [PubMed]
Rodenburg J, Vissers MN, Wiegman A, van Trotsenburg ASP, van der Graaf A, de Groot E, Wijburg FA, Kastelein JJP, Hutten BA, Statin treatment in children with familial hypercholesterolemia - The younger, the better. CIRCULATION 2007;116 (6):664-668 [PubMed]
Sankatsing RR, Wit FW, Pakker N, Vyankandondera J, Mmiro F, Okong P, Kastelein JJ, Lange JM, Stroes ES, Reiss P, Effects of nevirapine, compared with lamivudine, on lipids and lipoproteins in HIV-1-uninfected newborns: the stopping infection from mother-to-child via breast-feeding in Africa lipid substudy. J INFECT DIS 2007;196 (1):15-22 [PubMed]
Schouten O, Hoeks SE, Welten GMJM, Davignon J, Kastelein JJP, Vidakovic R, Feringa HHH, Dunkelgrun M, van Domburg RT, Bax JJ, Poldermans D, Effect of statin withdrawal on frequency of cardiac events after vascular surgery. AM J CARDIOL 2007;100 (2):316-320 [PubMed]
Shepherd J, Kastelein JJP, Bittner V, Deedwania P, Breazna A, Dobson S, Wilson DJ, Zuckerman A, Wenger NK, Effect of intensive lipid lowering with atorvastatin on renal function in patients with coronary heart disease: the Treating to New Targets (TNT) study. CLIN J AM SOC NEPHRO 2007;2 (6):1131-1139 [PubMed]
Souverein OW, Defesche JC, Zwinderman AH, Kastelein JJP, Tanck MWT, Influence of LDL-receptor mutation type on age at first cardiovascular event in patients with familial hypercholesterolaemia. EUR HEART J 2007;28 (3):299-304 [PubMed]
Vaessen SFC, Twisk J, Kastelein JJP, Kuivenhoven JA, Gene therapy in disorders of lipoprotein metabolism. CURR GENE THER 2007;7 (1):35-47 [PubMed]
van der Steeg WA, Boekholdt SM, Stein EA, El-Harchaoui K, Stroes ESG, Sandhu MS, Wareham NJ, Jukema JW, Luben R, Zwinderman AH, Kastelein JJP, Khaw KT, Role of the apolipoprotein B-apolipoprotein A-I ratio in cardiovascular risk assessment: a case-control analysis in EPIC-Norfolk. ANN INTERN MED 2007;146 (9):640-648 [PubMed]
van der Steeg WA, Hovingh GK, Klerkx AHEM, Hutten BA, Nootenboom IC, Levels JHM, van Tol A, Dallinga-Thie GM, Zwinderman AH, Kastelein JJP, Kuivenhoven JA, Cholesteryl ester transfer protein and hyperalphalipoproteinemia in Caucasians. J LIPID RES 2007;48 (3):674-682 [PubMed]
van der Steeg WA, Kastelein JJP. Dyslipidemie in: Hovingh GK, Somsen GA, editors. Probleemgeoriënteerd denken in de cardiologie en vasculaire geneeskunde; een praktijkboek voor de opleiding en de kliniek. Utrecht: De Tijdstroom; 2007., p. 223-230
van Leuven SI, Hezemans R, Levels JH, Snoek S, Stokkers PC, Hovingh GK, Kastelein JJP, Stroes ES, de Groot E, Hommes DW, Enhanced atherogenesis and altered high density lipoprotein in patients with Crohn's disease. J LIPID RES 2007;48 (12):2640-2646 [PubMed]
Barter PJ, Kastelein JJP, Targeting cholesteryl ester transfer protein for the prevention and management of cardiovascular disease. J AM COLL CARDIOL 2006;47 (3):492-499 [PubMed]
Barter P, Kastelein J, Translating today's science into clinical practice. ATHEROSCLEROSIS SUPP 2006;7 (1):1-2
Birjmohun RS, van der Steeg WA, Stroes ESG, Kastelein JJP, De rol van het 'high-density'-lipoproteine (HDL)-partikel in de atherogenese en de mogelijkheden om de concentratie daarvan te verhogen. NED TIJDSCHR GENEESKD 2006;150 (41):2245-2250 [PubMed]
Bisoendial RJ. High-density lipoprotein and C-reactive protein, friend and foe in cardiovascular disease. S.l.: s.n.; 2006. 174p. ISBN 9789090209784 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Stroes ESG)
Boekholdt SM, Hack CE, Sandhu MS, Luben R, Bingham SA, Wareham NJ, Peters RJG, Jukema JW, Day NE, Kastelein JJP, Khaw KT, C-reactive protein levels and coronary artery disease incidence and mortality in apparently healthy men and women: the EPIC-Norfolk prospective population study 1993-2003. ATHEROSCLEROSIS 2006;187 (2):415-422 [PubMed]
Boekholdt SM, Souverein OW, Tanck MWT, Hovingh GK, Kuivenhoven JA, Peters RIG, Jansen H, Schiffers PMH, van der Wall EE, Doevendans PA, Reitsma PH, Zwinderman AH, Kastelein JJP, Jukema JW, Common variants of multiple genes that control reverse cholesterol transport together explain only a minor part of the variation of HDL cholesterol levels. CLIN GENET 2006;69 (3):263-270 [PubMed]
Deedwania P, Barter P, Carmena R, Fruchart JC, Grundy SM, Haffner S, Kastelein JJP, LaRosa JC, Schachner H, Shepherd J, Waters DD, Reduction of low-density lipoprotein cholesterol in patients with coronary heart disease and metabolic syndrome: analysis of the Treating to New Targets study. LANCET 2006;368 (9539):919-928 [PubMed]
Goettsch WG, Heintjes EM, Kastelein JJP, Rabelink TJ, Johansson S, Herings RMC, Results from a rosuvastatin historical cohort study in more than 45,000 Dutch statin users, a PHARMO study. PHARMACOEPIDEM DR S 2006;15 (7):435-443 [PubMed]
Jakulj L, Vissers MN, Rodenburg J, Wiegman A, Trip MD, Kastelein JJP, Plant stanols do not restore endothelial function in pre-pubertal children with familial hypercholesterolemia despite reduction of low-density lipoprotein cholesterol levels. J PEDIATR-US 2006;148 (4):495-500 [PubMed]
Kastelein JJP, Wedel MK, Baker BF, Su J, Bradley JD, Yu RZ, Chuang E, Graham MJ, Crooke RM, Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B. CIRCULATION 2006;114 (16):1729-1735 [PubMed]
Klerkx AHEM, El Harchaoui K, van der Steeg WA, Boekholdt SM, Stroes ESG, Kastelein JJP, Kuivenhoven JA, Cholesteryl ester transfer protein (CETP) inhibition beyond raising high-density lipoprotein cholesterol levels: pathways by which modulation of CETP activity may alter atherogenesis. ARTERIOSCL THROM VAS 2006;26 (4):706-715 [PubMed]
Koeijvoets KCMC, van Rossum EFC, Dallinga-Thie GM, Steyerberg EW, Defesche JC, Kastelein JJP, Lamberts SWJ, Sijbrands EJG, A functional polymorphism in the glucocorticoid receptor gene and its relation to cardiovascular disease risk in familial hypercholesterolemia. J CLIN ENDOCR METAB 2006;91 (10):4131-4136 [PubMed]
Kramer A, Jansen ACM, van Aalst-Cohen ES, Tanck MWT, Kastelein JJP, Zwinderman AH, Relative risk for cardiovascular atherosclerotic events after smoking cessation: 6-9 years excess risk in individuals with familial hypercholesterolemia. BMC PUBLIC HEALTH 2006;6:262 [PubMed]
Maitland-van der Zee AH, Jukema JW, Zwinderman AH, Hallman DM, de Boer A, Kastelein JJP, de Knijff P, Apolipoprotein-E polymorphism and response to pravastatin in men with coronary artery disease (REGRESS). ACTA CARDIOL 2006;61 (3):327-331 [PubMed]
Meuwese MC, Franssen R, Stroes ESG, Kastelein JJP, And then there were acyl coenzyme A:cholesterol acyl transferase inhibitors. CURR OPIN LIPIDOL 2006;17 (4):426-430 [PubMed]
Nierman MC. Lipoprotein lipase S477X. From beneficial gene variant to gene therapy. S.l.: s.n.; 2006. 254p. ISBN 9789090213101 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Stroes ESG, Kuivenhoven JA)
Nieuwdorp M, Mooij HL, Kroon J, Atasever B, Spaan JAE, Ince C, Holleman F, Diamant M, Heine RJ, Hoekstra JBL, Kastelein JJP, Stroes ESG, Vink H, Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes. DIABETES 2006;55 (4):1127-1132 [PubMed]
Nieuwdorp M, van Haeften TW, Gouverneur MCLG, Mooij HL, van Lieshout MHP, Levi M, Meijers JCM, Holleman F, Hoekstra JBL, Vink H, Kastelein JJP, Stroes ESG, Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo. DIABETES 2006;55 (2):480-486 [PubMed]
Ozsoy RC, van Leuven SI, Kastelein JJP, Arisz L, Koopman MG, The dyslipidemia of chronic renal disease: effects of statin therapy. CURR OPIN LIPIDOL 2006;17 (6):659-666 [PubMed]
Rana JS, Jansen AC, Zwinderman AH, Nieuwdorp M, van Aalst-Cohen ES, Jukema JW, Trip MD, Kastelein JJP, Metabolic syndrome and risk of coronary, cerebral, and peripheral vascular disease in a large Dutch population with familial hypercholesterolemia. DIABETES CARE 2006;29 (5):1125-1127 [PubMed]
Rana JS, Jansen AC, Zwinderman AH, van Aalst-Cohen ES, Jukema JW, Trip MD, Kastelein JJP, Lipoprotein (a) and risk of cardiovascular disease in patients with metabolic syndrome in a population of familial hypercholesterolaemia. J INTERN MED 2006;260 (2):183-185 [PubMed]
Rip J. Lipoprotein lipase, hypertriglyceridemia and atherosclerosis. S.l.: s.n.; 2006. 242p. ISBN 9789090209036 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Kuivenhoven JA)
Rip J, Nierman MC, Ross CJ, Jukema JW, Hayden MR, Kastelein JJP, Stroes ESG, Kuivenhoven JA, Lipoprotein lipase S447X: a naturally occurring gain-of-function mutation. ARTERIOSCL THROM VAS 2006;26 (6):1236-1245 [PubMed]
Rip J, Nierman MC, Wareham NJ, Luben R, Bingham SA, Day NE, van Miert JNI, Hutten BA, Kastelein JJP, Kuivenhoven JA, Khaw KT, Boekholdt SM, Serum lipoprotein lipase concentration and risk for future coronary artery disease: the EPIC-Norfolk prospective population study. ARTERIOSCL THROM VAS 2006;26 (3):637-642 [PubMed]
Rip J, van Dijk KW, Sierts JA, Kastelein JJP, Twisk J, Kuivenhoven JA, AAV1-LPL(S447X) gene therapy reduces hypertriglyceridemia in apoE2 knock in mice. BBA-MOL CELL BIOL L 2006;1761 (10):1163-1168 [PubMed]
Rodenburg J, Vissers MN, Wiegman A, Miller ER, Ridker PM, Witztum JL, Kastelein JJP, Tsimikas S, Oxidized low-density lipoprotein in children with familial hypercholesterolemia and unaffected siblings: effect of pravastatin. J AM COLL CARDIOL 2006;47 (9):1803-1810 [PubMed]
Roest M, Rodenburg J, Wiegman A, Kastelein JJP, Voorbij HAM, Paraoxonase genotype and carotid intima-media thickness in children with familial hypercholesterolemia. EUR J CARDIOV PREV R 2006;13 (3):464-466 [PubMed]
Ross CJD, Twisk J, Bakker AC, Miao F, Verbart D, Rip J, Godbey T, Dijkhuizen P, Hermens WTJMC, Kastelein JJP, Kuivenhoven JA, Meulenberg JM, Hayden MR, Correction of feline lipoprotein lipase deficiency with adeno-associated virus serotype 1-mediated gene transfer of the lipoprotein lipase S447X beneficial mutation. HUM GENE THER 2006;17 (5):487-499 [PubMed]
Ross CJD, Twisk J, Kuivenhoven JA, Rip J, Kastelein JJ, Hayden MR, Gene therapy with lipoprotein lipase variant S447X - Response. ARTERIOSCL THROM VAS 2006;26 (3):E25-E28
Ueland T, Vissers MN, Wiegman A, Rodenburg J, Hutten B, Gullestad L, Ose L, Rifai N, Ridker PM, Kastelein JJP, Aukrust P, Semb AG, Increased inflammatory markers in children with familial hypercholesterolaemia. EUR J CLIN INVEST 2006;36 (3):147-152 [PubMed]
Vaessen SFC, Schaap FG, Kuivenhoven JA, Groen AK, Hutten BA, Boekholdt SM, Hattori H, Sandhu MS, Bingham SA, Luben R, Palmen JA, Wareham NJ, Humphries SE, Kastelein JJP, Talmud PJ, Khaw KT, Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study. J LIPID RES 2006;47 (9):2064-2070 [PubMed]
van Aalst-Cohen ES, Jansen ACM, Tanck MWT, Defesche JC, Trip MD, Lansberg PJ, Stalenhoef AFH, Kastelein JJP, Diagnosing familial hypercholesterolaemia: the relevance of genetic testing. EUR HEART J 2006;27 (18):2240-2246 [PubMed]
van der Graaf A, Hutten BA, Kastelein JJP, Vissers MN, Premature cardiovascular disease in young women with heterozygous familial hypercholesterolemia. EXPERT REV CARDIOVASC THER 2006;4 (3):345-351 [PubMed]
van Leuven SI, Kastelein JJP, Allison AC, Hayden MR, Stroes ESG, Mycophenolate mofetil (MMF): firing at the atherosclerotic plaque from different angles?. CARDIOVASC RES 2006;69 (2):341-347 [PubMed]
van Leuven SI, Kastelein JJP, D'Cruz DP, Hughes GR, Stroes ES, Atherogenesis in rheumatology. LUPUS 2006;15 (3):117-121 [PubMed]
van Leuven SI, Kastelein JJP, Hayden MR, Stroes ES, Mycophenolate mofetil as an immunomodulatory silver bullet in atherogenesis?. LUPUS 2006;15 (11 Suppl. S):11-17
Vriend JWJ, de Groot E, de Waal TT, Zijta FM, Kastelein JJP, Mulder BJM, Increased carotid and femoral intima-media thickness in patients after repair of aortic coarctation: influence of early repair. AM HEART J 2006;151 (1):242-247 [PubMed]
Walma EP, Visseren FLJ, Jukema JW, Kastelein JJP, Hoes AW, Stalenhoef AFH, Richtlijn 'diagnostiek en behandeling van familiaire hypercholesterolemie' van het College voor zorgverzekeringen. NED TIJDSCHR GENEESKD 2006;150 (1):18-23 [PubMed]
Waters DD, LaRosa JC, Barter P, Fruchart JC, Gotto AM Jr, Carter R, Breazna A, Kastelein JJP, Grundy SM, Effects of high-dose atorvastatin on cerebrovascular events in patients with stable coronary disease in the TNT (treating to new targets) study. J AM COLL CARDIOL 2006;48 (9):1793-1799 [PubMed]
Birjmohun RM, Stroes ESG, Kastelein JJP, Future strategies in the management of dyslipidemia. FUTURE CARDIOL 2005;1 (2):127-130
Birjmohun RS, Hutten BA, Kastelein JJP, Stroes ESG, Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds - A meta-analysis of randomized controlled trials. J AM COLL CARDIOL 2005;45 (2):185-197 [PubMed]
Bisoendial R, Birjmohun R, Keller T, van Leuven S, Levels H, Levi M, Kastelein J, Stroes E, In vivo effects of C-reactive protein (CRP)-infusion into humans. CIRC RES 2005;97 (12):e115-e116 [PubMed]
Bisoendial RJ, Hovingh GK, El Harchaoui K, Levels JHM, Tsimikas S, Pu K, Zwinderman AE, Kuivenhoven JA, Kastelein JJP, Stroes ESG, Consequences of cholesteryl ester transfer protein inhibition in patients with familial hypoalphalipoproteinemia. ARTERIOSCL THROM VAS 2005;25 (9):E133-E134 [PubMed]
Bisoendial RJ, Kastelein JJP, Levels JHM, Zwaginga JJ, van den Bogaard B, Reitsma PH, Meijers JCM, Hartman D, Levi M, Stroes ESG, Activation of inflammation and coagulation after infusion of C-reactive protein in humans. CIRC RES 2005;96 (7):714-716 [PubMed]
Bisoendial R, Kastelein J, Stroes E, In response to van den Berg et al: on the direct actions of CRP in humans. CIRC RES 2005;97 (7):e71 [PubMed]
Boekholdt SM. Genetic and biochemical risk factors in coronary artery disease. S.l.: s.n.; 2005. 280p. ISBN 90-9019174-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP, Peters RJG; copromotor(s): Jukema JW, Reitsma PH)
Boekholdt SM, Keller TT, Wareham NJ, Luben R, Bingham SA, Day NE, Sandhu MS, Jukema JW, Kastelein JJP, Hack CE, Khaw KT, Serum levels of type II secretory phospholipase A2 and the risk of future coronary artery disease in apparently healthy men and women - The EPIC-Norfolk Prospective Population study. ARTERIOSCL THROM VAS 2005;25 (4):839-846 [PubMed]
Boekholdt SM, Sacks FM, Jukema JW, Shepherd J, Freeman DJ, McMahon AD, Cambien F, Nicaud V, de Grooth GJ, Talmud PJ, Humphries SE, Miller GJ, Eiriksdottir G, Gudnason V, Kauma H, Kakko S, Savolainen MJ, Arca M, Montali A, Liu S, Lanz HJ, Zwinderman AH, Kuivenhoven JA, Kastelein JJP, Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment - Individual patient meta-analysis of 13,677 subjects. CIRCULATION 2005;111 (3):278-287 [PubMed]
Bots AFE, Kastelein JJP, Achieving lipid goals in real life: the Dutch DISCOVERY Study. INT J CLIN PRACT 2005;59 (12):1387-1394 [PubMed]
Cobbe SM, Kastelein JJP, A symposium: Statin Therapy: Setting New Standards in the Management of Dyslipidaemia - Foreword. EUR HEART J SUPPL 2005;7 (Suppl A):A3-A4
Cohen ES. Diagnostic criteria and risk factors for cardiovascular in familial hypercholesterolemia. S.l.: s.n.; 2005. 191p. ISBN 90-9019102-X [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Trip MD, Lansberg PJ)
de Groot E, Hovingh GK, Zwinderman AH, Wiegman A, Smit AJ, Kastelein JJP, Data density curves of B-mode ultrasound arterial wall thickness measurements in unaffected control and at-risk populations. INT ANGIOL 2005;24 (4):359-365 [PubMed]
Fouchier SW. Genetic determinants of cholesterol homeostasis. S.l.: s.n.; 2005. 149p. ISBN 90-9019319-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Defesche JC)
Fouchier SW, Kastelein JJP, Defesche JC, Update of the molecular basis of familial hypercholesterolemia in The Netherlands. HUM MUTAT 2005;26 (6):550-556 [PubMed]
Fouchier SW, Rodenburg J, Defesche JC, Kastelein JJP, Management of hereditary dyslipidaemia; the paradigm of autosomal dominant hypercholesterolaemia. EUR J HUM GENET 2005;13 (12):1247-1253 [PubMed]
Fouchier SW, Sankatsing RR, Peter J, Castillo S, Pocovi M, Alonso R, Kastelein JJP, Defesche JC, High frequency of APOB gene mutations causing familial hypobetalipoproteinaemia in patients of Dutch and Spanish descent. J MED GENET 2005;42 (4):e23 [PubMed]
Frisdal E, Klerkx AHEM, Le Goff W, Tanck MWT, Lagarde JP, Jukema JW, Kastelein JJP, Chapman MJ, Guerin M, Functional interaction between -629C/A, -971G/A and -1337C/T polymorphisms in the CETP gene is a major determinant of promoter activity and plasma CETP concentration in the REGRESS Study. HUM MOL GENET 2005;14 (18):2607-2618 [PubMed]
Hovingh GK. Molecular defects in the metabolism of the HDL particle and the consequences for atherosclerosis progression. S.l.: s.n.; 2005. 251p. ISBN 90-9019244-1 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Groen AK, Kuivenhoven JA)
Hovingh GK, de Groot E, van der Steeg W, Boekholdt SM, Hutten BA, Kuivenhoven JA, Kastelein JJP, Inherited disorders of HDL metabolism and atherosclerosis. CURR OPIN LIPIDOL 2005;16 (2):139-145 [PubMed]
Hovingh GK, Hutten BA, Holleboom AG, Petersen W, Rol P, Stalenhoef A, Zwinderman AH, de Groot E, Kastelein JJP, Kuivenhoven JA, Compromised LCAT function is associated with increased atherosclerosis. CIRCULATION 2005;112 (6):879-884 [PubMed]
Jakulj L, Trip MD, Sudhop T, von Bergmann K, Kastelein JJP, Vissers MN, Inhibition of cholesterol absorption by the combination of dietary plant sterols and ezetimibe: effects on plasma lipid levels. J LIPID RES 2005;46 (12):2692-2698 [PubMed]
Jansen ACM, van Aalst-Cohen ES, Hutten BA, Büller HR, Kastelein JJP, Prins MH, Guidelines were developed for data collection from medical records for use in retrospective analyses. J CLIN EPIDEMIOL 2005;58 (3):269-274 [PubMed]
Jansen ACM, van Aalst-Cohen ES, Tanck MWT, Cheng S, Fontecha MR, Li J, Defesche JC, Kastelein JJP, Genetic determinants of cardiovascular disease risk in familial hypercholesterolemia. ARTERIOSCL THROM VAS 2005;25 (7):1475-1481 [PubMed]
Kastelein J, Metabolic and cardiovascular disease: complications and consequences. ATHEROSCLEROSIS SUPP 2005;6 (2):1-2 [PubMed]
Kastelein JJP, Modifying plasma low-density lipoprotein and high-density lipoprotein cholesterol: what combinations are available in the future?. AM J CARDIOL 2005;96 (9A):20K-27K; discussion 34K-35K [PubMed]
Kastelein JJP, The realities of dyslipidaemia: what do the studies tell us?. EUR HEART J SUPPL 2005;7 (F):F27-F33
Kastelein JJP, Fouchier SW, Defesche JC, What promise does PCSK9 hold?. J AM COLL CARDIOL 2005;45 (10):1620-1621 [PubMed]
Kastelein JJP, Sager PT, de Groot E, Veltri E, Comparison of ezetimibe plus simvastatin versus simvastatin monotherapy on atherosclerosis progression in familial hypercholesterolemia: Design and rationale of the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression (ENHANCE) trial. AM HEART J 2005;149 (2):234-239 [PubMed]
Kastelein JJP, Sankatsing RR, Ezetimibe/simvastatin (INEGY) in the treatment of hyperlipidaemia. INT J CLIN PRACT 2005;59 (12):1464-1471 [PubMed]
Koeijvoets KCMC, Rodenburg J, Hutten BA, Wiegman A, Kastelein JJP, Sijbrands EJG, Low-density lipoprotein receptor genotype and response to pravastatin in children with familial hypercholesterolemia - Substudy of an intima-media thickness trial. CIRCULATION 2005;112 (20):3168-3173 [PubMed]
Koeijvoets KCMC, Wiegman A, Rodenburg J, Defesche JC, Kastelein JJP, Sijbrands EJG, Effect of low-density lipoprotein receptor mutation on lipoproteins and cardiovascular disease risk: a parent-offspring study. ATHEROSCLEROSIS 2005;180 (1):93-99 [PubMed]
Kuivenhoven JA, de Grooth GJ, Kawamura H, Klerkx AH, Wilhelm F, Trip MD, Kastelein JJP, Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with Pravastatin in type II dyslipidemia. AM J CARDIOL 2005;95 (9):1085-1088 [PubMed]
LaRosa JC, Grundy SM, Waters DD, Shear C, Barter P, Fruchart JC, Gotto AM, Greten H, Kastelein JJP, Shepherd J, Wenger NK, Intensive lipid lowering with atorvastatin in patients with stable coronary disease. NEW ENGL J MED 2005;352 (14):1425-1435 [PubMed]
Monraats PS, Rana JS, Nierman MC, Pires NMM, Zwinderman AH, Kastelein JJP, Kuivenhoven JA, de Maat MPM, Rittersma SZH, Schepers A, Doevendans PAF, de Winter RJ, Tio RA, Frants RR, Quax PHA, van der Laarse A, van der Wall EE, Jukema JW, Lipoprotein lipase gene polymorphisms and the risk of target vessel revascularization after percutaneous coronary intervention. J AM COLL CARDIOL 2005;46 (6):1093-1100 [PubMed]
Monraats PS, Rana JS, Zwinderman AH, de Maat MPM, Kastelein JP, Agema WRP, Doevendans PAF, de Winter RJ, Tio RA, Waltenberger J, Frants RR, van der Laarse A, van der Wall EE, Jukema JW, -455G/A polymorphism and preprocedural plasma levels of fibrinogen show no association with the risk of clinical restenosis in patients with coronary stent placement. THROMB HAEMOSTASIS 2005;93 (3):564-569 [PubMed]
Nierman MC, Prinsen BHCMT, Rip J, Veldman RJ, Kuivenhoven JA, Kastelein JJP, de Sain-van der Velden MGM, Stroes ESG, Enhanced conversion of triglyceride-rich lipoproteins and increased low-density lipoprotein removal in LPLS447X carriers. ARTERIOSCL THROM VAS 2005;25 (11):2410-2415 [PubMed]
Nierman MC, Rip J, Kuivenhoven JA, van Raalte DH, Hutten BA, Sakai N, Kastelein JJP, Stroes ESG, Carriers of the frequent lipoprotein lipase S447X variant exhibit enhanced postprandial apoprotein B-48 clearance. METABOLISM 2005;54 (11):1499-1503 [PubMed]
Nierman MC, Rip J, Twisk J, Meulenberg JJM, Kastelein JJP, Stroes ESG, Kuivenhoven JA, Gene therapy for genetic lipoprotein lipase deficiency: from promise to practice. NETH J MED 2005;63 (1):14-19 [PubMed]
Nieuwdorp M, Meuwese MC, Vink H, Hoekstra JBL, Kastelein JJP, Stroes ESG, The endothelial glycocalyx: a potential barrier between health and vascular disease. CURR OPIN LIPIDOL 2005;16 (5):507-511 [PubMed]
Ozsoy RC, Koopman MG, Kastelein JJP, Arisz L, The acute effect of atorvastatin on proteinuria in patients with chronic glomerulonephritis. CLIN NEPHROL 2005;63 (4):245-249 [PubMed]
Pedersen TR, Faergeman O, Kastelein JJP, Olsson AG, Tikkanen MJ, Holme I, Larsen ML, Bendiksen FS, Lindahl C, Szarek M, Tsai J, High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trial. JAMA-J AM MED ASSOC 2005;294 (19):2437-2445 [PubMed]
Rana JS. The cardiovascular metabolic syndrome. S.l.: s.n.; 2005. 229p. ISBN 9090198040 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Jukema JW)
Rana JS, Monraats PS, Zwinderman AH, de Maat MPM, Kastelein JJP, Agema WRP, Doevendans PAF, de Winter RJ, Tio RA, Waltenberger J, Frants RR, van der Laarse A, van der Wall EE, Jukema JW, Pre-procedural levels of erythrocyte sedimentation rate (ESR) and risk of clinical restenosis in patients with percutaneous coronary intervention and coronary stent placement. THROMB HAEMOSTASIS 2005;94 (4):892-894 [PubMed]
Rana JS, Monraats PS, Zwinderman AH, de Maat MPM, Kastelein JJP, Doevendans PAF, de Winter RJ, Tio RA, Frants RR, van der Laarse A, van der Wall EE, Jukema JW, Metabolic syndrome and risk of restenosis in patients undergoing percutaneous coronary intervention. DIABETES CARE 2005;28 (4):873-877 [PubMed]
Rip J, Nierman MC, Sierts JA, Petersen W, van den Oever K, van Raalte D, Ross CJD, Hayden MR, Bakker AC, Dijkhuizen P, Hermens WT, Twisk J, Stroes E, Kastelein JJP, Kuivenhoven JA, Meulenberg JM, Gene therapy for lipoprotein lipase deficiency: Working toward clinical application. HUM GENE THER 2005;16 (11):1276-1286 [PubMed]
Rodenburg J. Familial hypercholesterolemia in childhood: diagnostics, therapeutical options and risk stratification. S.l.: s.n.; 2005. 239p. ISBN 90-9019673-0 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Wiegman A, Vissers MN, Hutten BA)
Roest M, Jansen ACM, Barendrecht A, Leus FR, Kastelein JJP, Voorbij HAM, Variation at the paraoxonase gene locus contributes to carotid arterial wall thickness in subjects with familial hypercholesterolemia. CLIN BIOCHEM 2005;38 (2):123-127 [PubMed]
Ross CJD, Liu G, Kuivenhoven JA, Twisk J, Rip J, van Dop W, Excoffon KJDA, Lewis SME, Kastelein JJ, Hayden MR, Complete rescue of lipoprotein lipase-deficient mice by somatic gene transfer of the naturally occurring LPLS447X beneficial mutation. ARTERIOSCL THROM VAS 2005;25 (10):2143-2150 [PubMed]
Rotmans JI. Therapeutic strategies to prevent stenosis in arteriovenous grafts for hemodialysis. Studies in a porcine arteriovenous graft model. S.l.: s.n.; 2005. 160p. ISBN 90-9018634-4 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Stroes ESG, Pasterkamp G)
Sankatsing RR, de Groot E, Jukema JW, de Feyter PJ, Pennell DJ, Schoenhagen P, Nissen SE, Stroes ESG, Kastelein JJP, Surrogate markers for atherosclerotic disease. CURR OPIN LIPIDOL 2005;16 (4):434-441 [PubMed]
Sankatsing RR, Fouchier SW, de Haan S, Hutten BA, de Groot E, Kastelein JJP, Stroes ESG, Hepatic and cardiovascular consequences of familial hypobetalipoproteinemia. ARTERIOSCL THROM VAS 2005;25 (9):1979-1984 [PubMed]
van Aalst-Cohen ES, Jansen ACM, Boekholdt SM, Tanck MWT, Fontecha MR, Cheng S, Li J, Defesche JC, Kuivenhoven JA, Kastelein JJP, Genetic determinants of plasma HDL-cholesterol levels in familial hypercholesterolemia. EUR J HUM GENET 2005;13 (10):1137-1142 [PubMed]
van der Harst P, Kastelein JJP, van Gilst WH, Statinen: voorlopig niet als regel maximaal doseren. NED TIJDSCHR GENEESKD 2005;149 (46):2589-2589; author reply 2590 [PubMed]
van der Steeg WA, El-Harchaoui K, Kuivenhoven JA, Kastelein JJP, Increasing high-density lipoprotein cholesterol through cholesteryl ester transfer protein inhibition: a next step in the fight against cardiovascular disease?. CURR DRUG TARGETS CARDIOVASC HAEMATOL DISORD 2005;5 (6):481-488 [PubMed]
van Himbergen TM, Roest M, de Graaf J, Jansen EHJM, Hattori H, Kastelein JJP, Voorbij HAM, Stalenhoef AFH, van Tits LJH, Indications that paraoxonase-1 contributes to plasma high density lipoprotein levels in familial hypercholesterolemia. J LIPID RES 2005;46 (3):445-451 [PubMed]
van Leuven SI, Kastelein JJP, Atorvastatin. EXPERT OPIN PHARMACO 2005;6 (7):1191-1203 [PubMed]
van Leuven SI, Kastelein JJP, Hayden MR, d'Cruz D, Hughes GR, Stroes ES, Cardiovascular disease in systemic lupus erythematosus: has the time for action come?. CURR OPIN LIPIDOL 2005;16 (5):501-506 [PubMed]
van Wissen S, Smilde TJ, Trip MD, Stalenhoef AFH, Kastelein JJP, Long-term safety and efficacy of high-dose Atorvastatin treatment in patients with familial hypercholesterolemia. AM J CARDIOL 2005;95 (2):264-266 [PubMed]
Vriend JWJ, de Groot E, Bouma BJ, Hrudova J, Kastelein JJP, Tijssen JGP, Mulder BJM, Carotid intima-media thickness in post-coarctectomy patients with exercise induced hypertension. HEART 2005;91 (7):962-963 [PubMed]
Vriend JWJ, Engelfriet PM, de Groot E, Elsen BM, Kastelein JJP, Mulder BJM, Age at repair and left ventricular mass in patients after repair of aortic coarctation. J THORAC CARDIOV SUR 2005;130 (3):896-897 [PubMed]
Vriend JWJ, Zwinderman AH, de Groot E, Kastelein JJP, Bouma BJ, Mulder BJM, Predictive value of mild, residual descending aortic narrowing for blood pressure and vascular damage in patients after repair of aortic coarctation. EUR HEART J 2005;26 (1):84-90 [PubMed]
Wegman JJ, Hu X, Tan H, Bergen AAB, Trip MD, Kastelein JJP, Smulders YM, Patients with premature coronary artery disease who carry the ABCC6 R1141X mutation have no Pseudoxanthoma Elasticum phenotype. INT J CARDIOL 2005;100 (3):389-393 [PubMed]
Agema WRP, de Maat MPM, Zwinderman AH, Kastelein JJP, Rabelink TJ, van Boven AJ, Feskens EJM, Boer JMA, van der Wall EE, Jukema JW, An integrated evaluation of endothelial constitutive nitric oxide synthase polymorphisms and coronary artery disease in men. CLIN SCI 2004;107 (3):255-261 [PubMed]
Agema WRP, Jukema JW, de Maat MPM, Zwinderman AH, Kastelein JJP, Rabelink TJ, van der Wall EE, Pharmacogenetics of the CD14 endotoxin receptor polymorphism and progression of coronary atherosclerosis. THROMB HAEMOSTASIS 2004;91 (5):986-990 [PubMed]
Birjmohun RS, Hutten BA, Kastelein JJP, Stroes ESG, Increasing HDL cholesterol with extended-release nicotinic acid: from promise to practice. NETH J MED 2004;62 (7):229-234 [PubMed]
Boekholdt SM, Kuivenhoven JA, Hovingh GK, Jukema JW, Kastelein JJP, van Tol A, CETP gene variation: relation to lipid parameters and cardiovascular risk. CURR OPIN LIPIDOL 2004;15 (4):393-398 [PubMed]
Boekholdt SM, Kuivenhoven JA, Wareham NJ, Peters RJG, Jukema JW, Luben R, Bingham SA, Day NE, Kastelein JJP, Khaw KT, Plasma levels of cholesteryl ester transfer protein and the risk of future coronary artery disease in apparently healthy men and women: the prospective EPIC (European Prospective Investigation into Cancer and nutrition)-Norfolk population study. CIRCULATION 2004;110 (11):1418-1423 [PubMed]
Boekholdt SM, Peters RJG, de Maat MPM, Zwinderman AH, van der Wall EE, Reitsma PH, Jukema JW, Kastelein JJP, Interaction between a genetic variant of the platelet fibrinogen receptor and fibrinogen levels in determining the risk of cardiovascular events. AM HEART J 2004;147 (1):181-186 [PubMed]
Büller HR, Kastelein JJP, Stroes ESG, editors, Vasculaire geneeskunde; 2e herz dr. Alphen a/d Rijn: van Zuiden; 2004. -p.
Büller HR, Kastelein JJP, Stroes ESG, editors, Vasculaire geneeskunde; 2e herz. dr. Alphen/ad Rijn: Van Zuiden; 2004. -p.
Büller HR, Kastelein JJP, Stroes ESG, editors, Vasculaire geneeskunde; 2e herz. dr. Alphen a/d Rijn: Van Zuiden; 2004. -p.
Defesche JC, Lansberg PJ, Umans-Eckenhausen MAW, Kastelein JJP, Advanced method for the identification of patients with inherited hypercholesterolemia. SEMIN VASC MED 2004;4 (1):59-65 [PubMed]
de Groot E, Hovingh GK, Wiegman A, Duriez P, Smit AJ, Fruchart JC, Kastelein JJP, Measurement of arterial wall thickness as a surrogate marker for atherosclerosis. CIRCULATION 2004;109 (23 Suppl 1):III33-III38 [PubMed]
de Grooth GJ, Klerkx AHEM, Stroes ESG, Stalenhoef AFH, Kastelein JJP, Kuivenhoven JA, A review of CETP and its relation to atherosclerosis. J LIPID RES 2004;45 (11):1967-1974 [PubMed]
de Grooth GJ, Smilde TJ, van Wissen S, Klerkx AHEM, Zwinderman AH, Fruchart JC, Kastelein JJP, Stalenhoef AFH, Kuivenhoven JA, The relationship between cholesteryl ester transfer protein levels and risk factor profile in patients with familial hypercholesterolemia. ATHEROSCLEROSIS 2004;173 (2):261-267 [PubMed]
de Grooth GJ, Zerba KE, Huang SP, Tsuchihashi Z, Kirchgessner T, Belder R, Vishnupad P, Hu B, Klerkx AHEM, Zwinderman AH, Jukema JW, Sacks FM, Kastelein JJP, Kuivenhoven JA, The cholesteryl ester transfer protein (CETP) TaqIB polymorphism in the cholesterol and recurrent events study: No interaction with the response to pravastatin therapy and no effects on cardiovascular outcome - A prospective analysis of the CETP TaqIB polymorphism on cardiovascular outcome and interaction with cholesterol-lowering therapy. J AM COLL CARDIOL 2004;43 (5):854-857 [PubMed]
Foucher C, Rattier S, Flavell DM, Talmud PJ, Humphries SE, Kastelein JJP, Ayyobi A, Pimstone S, Frohlich J, Ansquer JC, Steiner G, Response to micronized fenofibrate treatment is associated with the peroxisome-proliferator-activated receptors alpha G/C intron7 polymorphism in subjects with type 2 diabetes. PHARMACOGENETICS 2004;14 (12):823-829 [PubMed]
Fouchier SW, Defesche JC, Kastelein JJP, Sijbrands EJG, Familial defective apolipoprotein B versus familial hypercholesterolemia: an assessment of risk. SEMIN VASC MED 2004;4 (3):259-264 [PubMed]
Fruchart JC, Nierman MC, Stroes ESG, Kastelein JJP, Duriez P, New risk factors for atherosclerosis and patient risk assessment. CIRCULATION 2004;109 (23 Suppl 1):III15-III19 [PubMed]
Homsma SJ, Lansberg PJ, Kastelein JJ, Actieve opsporing van patiënten met familiaire hypercholesterolemie en verzekerbaarheid voor levens- en arbeidsongeschiktheidsverzekeringen. NED TIJDSCHR GENEESKD 2004;148 (10):493-496 [PubMed]
Hovingh GK, Brownlie A, Bisoendial RJ, Dube MP, Levels JHM, Petersen W, Dullaart RPF, Stroes ESG, Zwinderman AH, de Groot E, Hayden MR, Kuivenhoven JA, Kastelein JJP, A novel ApoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease. J AM COLL CARDIOL 2004;44 (7):1429-1435 [PubMed]
Hovingh GK, Kuivenhoven JA, Bisoendial RJ, Groen AK, van Dam M, van Tol A, Wellington C, Hayden MR, Smelt AHM, Kastelein JJP, HDL deficiency and atherosclerosis: lessons from Tangier disease. J INTERN MED 2004;255 (2):299-301 [PubMed]
Jansen ACM, van Aalst-Cohen ES, Tanck MW, Trip MD, Lansberg PJ, Liem AH, van Lennep HWOR, Sijbrands EJG, Kastelein JJP, The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients. J INTERN MED 2004;256 (6):482-490 [PubMed]
Jukema JW, Lenselink M, de Grooth GJ, Boekholdt SM, Liem AH, Kuivenhoven JA, Kastelein JJP, Enhancing reverse cholesterol transport/raising HDL cholesterol: new options for prevention and treatment of cardiovascular disease. NETH HEART J 2004;12 (11):491-508
Kastelein J, Cardiovascular risk--through the ages. ATHEROSCLEROSIS SUPP 2004;5 (2):1-2 [PubMed]
Kastelein J, Polymorphisms, practicalities and pleiotropism. INT J CLIN PRACT 2004;58 (Suppl. 143):1-2
Kastelein JJP, Should rosuvastatin be withdrawn from the market?. LANCET 2004;364 (9445):1577-8; author reply 1578-9 [PubMed]
Kastelein JJP, de Groot E, Sankatsing R, Atherosclerosis measured by B-mode ultrasonography: Effect of statin therapy on disease progression. AM J MED 2004;116 (Suppl 6A):31S-36S [PubMed]
Kastelein JJP, Stroes ESG, de Groot E, Subclinical atherosclerosis as a target of therapy: Potential role of statins. AM J CARDIOL 2004;93 (6):737-740 [PubMed]
Klerkx AHEM, de Grooth GJ, Zwinderman AH, Jukema JW, Kuivenhoven JA, Kastelein JJP, Cholesteryl ester transfer protein concentration is associated with progression of atherosclerosis and response to pravastatin in men with coronary artery disease (REGRESS). EUR J CLIN INVEST 2004;34 (1):21-28 [PubMed]
Maitland-van der Zee AH, Klungel OH, Stricker BHC, Veenstra DL, Kastelein JJP, Hofman A, Witteman JCM, Leufkens HGM, van Duijn CM, de Boer A, Pharmacoeconomic evaluation of testing for angiotensin-converting enzyme genotype before starting beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor therapy in men. PHARMACOGENETICS 2004;14 (1):53-60 [PubMed]
Maitland-van der Zee AH, Stricker BHC, Klungel OH, Kastelein JJP, Hofman A, Witteman JCM, Leufkens HGM, van Duijn CM, de Boer A, Effectiveness of HMG-CoA reductase inhibitors is modified by the ACE insertion deletion polymorphism. ATHEROSCLEROSIS 2004;175 (2):377-379 [PubMed]
Netea MG, Hijmans A, van Wissen S, Smilde TJ, Trip MD, Kullberg BJ, de Boo T, van der Meer JWM, Kastelein JJP, Stalenhoef AFH, Stalenhorf AFH, Toll-like receptor-4 Asp299Gly polymorphism does not influence progression of atherosclerosis in patients with familial hypercholesterolaemia. EUR J CLIN INVEST 2004;34 (2):94-99 [PubMed]
Pedersen TR, Faergeman O, Kastelein JJP, Olsson AG, Tikkanen MJ, Holme I, Larsen ML, Bendiksen FS, Lindahl C, Palmer G, Design and baseline characteristics of the incremental decrease in end points through aggressive lipid lowering study. AM J CARDIOL 2004;94 (6):720-724 [PubMed]
Rodenburg J, Vissers MN, Daniels SR, Wiegman A, Kastelein JJP, Lipid-lowering medications. PEDIATR ENDOCRINOL REV 2004;2 (Suppl. 1):171-180 [PubMed]
Rodenburg J, Vissers MN, Trip MD, Wiegman A, Bakker HD, Kastelein JJP, The spectrum of statin therapy in hyperlipidemic children. SEMIN VASC MED 2004;4 (4):313-320 [PubMed]
Rodenburg J, Vissers MN, Wiegman A, Trip MD, Bakker HD, Kastelein JJP, Familial hypercholesterolemia in children. CURR OPIN LIPIDOL 2004;15 (4):405-411 [PubMed]
Rodenburg J, Wiegman A, Vissers MN, Kastelein JJP, Stalenhoef AFH, A boy with autosomal recessive hypercholesterolaemia. NETH J MED 2004;62 (3):89-93 [PubMed]
Ross CJD, Twisk J, Meulenberg JM, Liu G, van den Oever K, Moraal E, Hermens WT, Rip J, Kastelein JJP, Kuivenhoven JA, Hayden MR, Long-term correction of murine lipoprotein lipase deficiency with AAV1-mediated gene transfer of the naturally occurring LPLS447X beneficial mutation. HUM GENE THER 2004;15 (9):906-919 [PubMed]
Rotmans JI, Verhagen HJM, Velema E, de kleijn DPV, van den Heuvel M, Kastelein JJP, Pasterkamp G, Stroes ESG, Local overexpression of C-type natriuretic peptide ameliorates vascular adaptation of porcine hemodialysis grafts. KIDNEY INT 2004;65 (5):1897-1905 [PubMed]
Shepherd J, Hunninghake DB, Stein EA, Kastelein JJP, Harris S, Pears J, Hutchinson HG, Safety of rosuvastatin. AM J CARDIOL 2004;94 (7):882-888 [PubMed]
van Aalst-Cohen ES, Jansen ACM, de Jongh S, de Sauvage Nolting PRW, Kastelein JJP, Clinical, diagnostic, and therapeutic aspects of familial hypercholesterolemia. SEMIN VASC MED 2004;4 (1):31-41 [PubMed]
van Aalst-Cohen ES, Trip MD, Vissers MN, Rodenburg J, Kastelein JJP, Clinical, diagnostic and therapeutic aspects of (inherited) hypercholesterolemia. DRUG DISCOV TODAY 2004;1 (2):165-170
van Bellen A, Defesche JC, Kastelein JJP, Wiegman A. Familial hypercholesterolemia in: Poortman Y, Steegers R, Kluft C, editors. The increasing role of nutrition and genomics in the prevention and management of disease. S.l.: s.n.; 2004., p. hfst 6
van der Steeg WA, Kuivenhoven JA, Klerkx AH, Boekholdt SM, Hovingh GK, Kastelein JJP, Role of CETP inhibitors in the treatment of dyslipidemia. CURR OPIN LIPIDOL 2004;15 (6):631-636 [PubMed]
van Leth F, Phanuphak P, Stroes E, Gazzard B, Cahn P, Raffi F, Wood R, Bloch M, Katlama C, Kastelein JJP, Schechter M, Murphy RL, Horban A, Hall DB, Lange JMA, Reiss P, Nevirapine and efavirenz elicit different changes in lipid profiles in antiretroviral-therapy-naive patients infected with HIV-1. PLOS MED 2004;1 (1):e19-74 [PubMed]
van Tits LJH, Smilde TJ, van Wissen S, de Graaf J, Kastelein JJP, Stalenhoef AFH, Effects of atorvastatin and simvastatin on low-density lipoprotein subfraction profile, low-density lipoprotein oxidizability, and antibodies to oxidized low-density lipoprotein in relation to carotid intima media thickness in familial hypercholesterolemia. J INVEST MED 2004;52 (3):177-184 [PubMed]
Vriend JJW, de Groot E, Kastelein JJP, Mulder BJM, Carotid and femoral B-mode ultrasound intima-media thickness measurements in adult post-coarctectomy patients. INT ANGIOL 2004;23 (1):41-46 [PubMed]
Wiegman A, de Groot E, Hutten BA, Rodenburg J, Gort J, Bakker HD, Sijbrands EJG, Kastelein JJP, Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia. LANCET 2004;363 (9406):369-370 [PubMed]
Wiegman A, Hutten BA, de Groot E, Rodenburg J, Bakker HD, Büller HR, Sijbrands EJG, Kastelein JJP, Efficacy and safety of statin therapy in children with familial hypercholesterolemia - A randomized controlled trial. JAMA-J AM MED ASSOC 2004;292 (3):331-337 [PubMed]
Wiersma HE, Wiegman A, Koopmans RP, Bakker HD, Kastelein JJP, van Boxtel CJ, Steady-state pharmacokinetics of pravastatin in children with familial hypercholesterolaemia. CLIN DRUG INVEST 2004;24 (2):113-120 [PubMed]
Wonderling D, Umans-Eckenhausen MAW, Marks D, Defesche JC, Kastelein JJP, Thorogood M, Cost-effectiveness analysis of the genetic screening program for familial hypercholesterolemia in the Netherlands. SEMIN VASC MED 2004;4 (1):97-104 [PubMed]
Barter P, Kastelein J, Nunn A, Hobbs R, High density lipoproteins (HDLs) and atherosclerosis; the unanswered questions. ATHEROSCLEROSIS 2003;168 (2):195-211 [PubMed]
Bisoendial RJ, Hovingh GK, Levels JHM, Lerch PG, Andresen I, Hayden MR, Kastelein JJP, Stroes ESG, Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein. CIRCULATION 2003;107 (23):2944-2948 [PubMed]
Boekholdt SM, Agema WRP, Peters RJG, Zwinderman AH, van der Wall EE, Reitsma PH, Kastelein JJP, Jukema JW, Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events. CIRCULATION 2003;107 (19):2416-2421 [PubMed]
Boekholdt SM, Peters RJG, Fountoulaki K, Kastelein JJP, Sijbrands EJG, Molecular variation at the apolipoprotein B gene locus in relation to lipids and cardiovascular disease: a systematic meta-analysis. HUM GENET 2003;113 (5):417-425 [PubMed]
de Grooth GJ. Cholesteryl ester transfer protein. Its role in cardiovascular disease and drug development. S.l.: s.n.; 2003. 166p. ISBN 90 74384 03 x [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Stalenhoef AFH, Kuivenhoven JA)
de Jongh S, Vissers MN, Rol P, Bakker HD, Kastelein JJP, Stroes ESG, Plant sterols lower LDL cholesterol without improving endothelial function in prepubertal children with familial hypercholesterolaemia. J INHERIT METAB DIS 2003;26 (4):343-351 [PubMed]
de Sauvage Nolting PRW, Defesche JC, Buirma RJA, Hutten BA, Lansberg PJ, Kastelein JJP, Prevalence and significance of cardiovascular risk factors in a large cohort of patients with familial hypercholesterolaemia. J INTERN MED 2003;253 (2):161-168 [PubMed]
Descamps OS, de Meester A, Cheron P, Kastelein JJ, Heller FR, Silent ischaemia in familial hypercholesterolemia. ATHEROSCLEROSIS SUPP 2003;4 (3):7-8 [PubMed]
Elrayess MA, Webb KE, Flavell DM, Syvänne M, Taskinen MR, Frick MH, Nieminen MS, Kesäniemi YA, Pasternack A, Jukema JW, Kastelein JJP, Zwinderman AH, Humphries SE, A novel functional polymorphism in the PECAM-1 gene (53G>A) is associated with progression of atherosclerosis in the LOCAT and REGRESS studies. ATHEROSCLEROSIS 2003;168 (1):131-138 [PubMed]
Hoogendijk CF, Scholtz CL, Pimstone SM, Ehrenborg E, Kastelein JJP, Defesche JC, Thiart R, du Plessis L, de Villiers JNP, Zaahl MG, Delport R, Rubinsztein DC, Raffel LJ, Grim CE, Mediene-Benchekor S, Amouyel P, Brousseau T, Steyn K, Lombard CJ, Hayden MR, Kotze MJ, Allelic variation in the promoter region of the LDL receptor gene: analysis of an African-specific variant in the FP2 cis-acting regulatory element. MOL CELL PROBE 2003;17 (4):175-181 [PubMed]
Hovingh GK, van Wijland MJA, Brownlie A, Bisoendial RJ, Hayden MR, Kastelein JJP, Groen AK, The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia. J LIPID RES 2003;44 (6):1251-1255 [PubMed]
Jansen ACM. Familial hypercholesterolemia. The determination of phenotype. S.l.: s.n.; 2003. 167p. ISBN 90-9017543-1 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Sijbrands EJG, Tanck MWT)
Kastelein J, What future for combination therapies?. INT J CLIN PRACT 2003;134 (134):45-50 [PubMed]
Kastelein JJP, The future of lipid-lowering therapy: the big picture. NETH J MED 2003;61 (5 Suppl):35-39 [PubMed]
Kastelein JJP, Wiegman A, de Groot E, Surrogate markers of atherosclerosis: impact of statins. ATHEROSCLEROSIS SUPP 2003;4 (1):31-36 [PubMed]
Klerkx AHEM, Tanck MWT, Kastelein JJP, Molhuizen HOF, Jukema JW, Zwinderman AH, Kuivenhoven JA, Haplotype analysis of the CETP gene: not TaqIB, but the closely linked -629C-->A polymorphism and a novel promoter variant are independently associated with CETP concentration. HUM MOL GENET 2003;12 (2):111-123 [PubMed]
Kuivenhoven JA, Hovingh GK, van Tol A, Jauhiainen M, Ehnholm C, Fruchart JC, Brinton EA, Otvos JD, Smelt AHM, Brownlee A, Zwinderman AH, Hayden MR, Kastelein JJP, Heterozygosity for ABCA1 gene mutations: effects on enzymes, apolipoproteins and lipoprotein particle size. ATHEROSCLEROSIS 2003;171 (2):311-319 [PubMed]
Maitland-van der Zee AH, Stricker BHC, Klungel OH, Mantel-Teeuwisse AK, Kastelein JJP, Hofman A, Leufkens HGM, van Duijn CM, de Boer A, Adherence to and dosing of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitors in the general population differs according to apolipoprotein E-genotypes. PHARMACOGENETICS 2003;13 (4):219-223 [PubMed]
Nanjee MN, Stocks J, Cooke CJ, Molhuizen HOF, Marcovina S, Crook D, Kastelein JP, Miller NE, A novel LCAT mutation (Phe382-->Val) in a kindred with familial LCAT deficiency and defective apolipoprotein B-100. ATHEROSCLEROSIS 2003;170 (1):105-113 [PubMed]
Nolting PRWdS, de Groot E, Zwinderman AH, Buirma RJA, Trip MD, Kastelein JJP, Regression of carotid and femoral artery intima-media thickness in familial hypercholesterolemia: Treatment with simvastatin. ARCH INTERN MED 2003;163 (15):1837-1841 [PubMed]
Ozsoy RC, Kastelein JJP, Arisz L, Koopman MG, Atorvastatin and the dyslipidemia of early renal failure. ATHEROSCLEROSIS 2003;166 (1):187-194 [PubMed]
Rotmans JI, Velema E, Verhagen HJM, Blankensteijn JD, Kastelein JJP, de Kleijn DPV, Yo M, Pasterkamp G, Stroes ESG, Rapid, arteriovenous graft failure due to intimal hyperplasia: A porcine, bilateral, carotid arteriovenous graft model. J SURG RES 2003;113 (1):161-171 [PubMed]
Semb AG, van Wissen S, Ueland T, Smilde T, Waehre T, Tripp MD, Frøland SS, Kastelein JJP, Gullestad L, Pedersen TR, Aukrust P, Stalenhoef AFH, Raised serum levels of soluble CD40 ligand in patients with familial hypercholesterolemia: Downregulatory effect of statin therapy. J AM COLL CARDIOL 2003;41 (2):275-279 [PubMed]
Singaraja RR. The role of abca1 in athrosclerosis: lessons from in vitro and in vivo models. S.l.: s.n.; 2003. 239p. ISBN 90-9017228-9 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP, Hayden MR; copromotor(s): )
Singaraja RR, Brunham LR, Visscher H, Kastelein JJP, Hayden MR, Efflux and atherosclerosis - The clinical and biochemical impact of variations in the ABCA1 gene. ARTERIOSCL THROM VAS 2003;23 (8):1322-1332 [PubMed]
Tanck MWT, Klerkx AHEM, Jukema JW, de Knijff P, Kastelein JJP, Zwinderman AH, Estimation of multilocus haplotype effects using weighted penalised log-likelihood: Analysis of five sequence variations at the cholesteryl ester transfer protein gene locus. ANN HUM GENET 2003;67 (Part 2):175-184 [PubMed]
Trip MD, van Wissen S, Smilde TJ, Hutten BA, Stalenhoef AFH, Kastelein JJP, Effect of atorvastatin (80 mg) and simvastatin (40 mg) on plasma fibrinogen levels and on carotid intima media thickness in patients with familial hypercholesterolemia. AM J CARDIOL 2003;91 (5):604-606 [PubMed]
Umans-Eckenhausen MAW, Defesche JC, van Dam MJ, Kastelein JJP, Long-term compliance with lipid-lowering medication after genetic screening for familial hypercholesterolemia. ARCH INTERN MED 2003;163 (1):65-68 [PubMed]
van der Valk M, Sauerwein HP, Kastelein JJP, Reiss P, Lipodystrophy associated with treatment of HIV-1 infection. ADVERSE DRUG REACT BULL 2003;218:835-838
van Vugt RM, Kater L, Dijkstra PF, Schardijn GH, Kastelein JJ, Bijlsma JW, The outcome of angiography in patients with Raynaud's phenomenon: an unexpected role for atherosclerosis and hypercholesterolemia. CLIN EXP RHEUMATOL 2003;21 (4):445-450 [PubMed]
van Wissen S. Aggressive lipid lowering in patients with familial hypercholesterolaemia. S.l.: s.n.; 2003. 150p. ISBN 90 5170 690 1 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP, Stalenhoef AFH; copromotor(s): Büller HR)
van Wissen S, Smilde TJ, de Groot E, Hutten BA, Kastelein JJP, Stalenhoef AFH, The significance of femoral intima-media thickness and plaque scoring in the Atorvastatin versus Simvastatin on Atherosclerosis Progression (ASAP) study. J CARDIOVASC RISK 2003;10 (6):451-455 [PubMed]
van Wissen S, Smilde TJ, Trip MD, de Boo T, Kastelein JJP, Stalenhoef AFH, Long term statin treatment reduces lipoprotein(a) concentrations in heterozygous familial hypercholesterolaemia. HEART 2003;89 (8):893-896 [PubMed]
Wiegman A. Pediatric implications of heterozygous familial hypercholesterolemia. S.l.: s.n.; 2003. 147p. ISBN 90-9017042-1 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP, Heymans HSA; copromotor(s): Bakker HD, Sijbrands EJG)
Wiegman A, Rodenburg J, de Jongh S, Defesche JC, Bakker HD, Kastelein JJP, Sijbrands EJG, Family history and cardiovascular risk in familial hypercholesterolemia - Data in more than 1000 children. CIRCULATION 2003;107 (11):1473-1478 [PubMed]
Wiegman A, Sijbrands EJG, Rodenburg J, Defesche JC, de Jongh S, Bakker HD, Kastelein JJP, The apolipoprotein epsilon4 allele confers additional risk in children with familial hypercholesterolemia. PEDIATR RES 2003;53 (6):1008-1012 [PubMed]
Attie AD, Hamon Y, Brooks-Wilson AR, Gray-Keller MP, MacDonald MLE, Rigot V, Tebon A, Zhang LH, Mulligan JD, Singaraja RR, Bitgood JJ, Cook ME, Kastelein JJP, Chimini G, Hayden MR, Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken. J LIPID RES 2002;43 (10):1610-1617 [PubMed]
Attie AD, Krauss RM, Gray-Keller MP, Brownlie A, Miyazaki M, Kastelein JJ, Lusis AJ, Stalenhoef AFH, Stoehr JP, Hayden MR, Ntambi JM, Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J LIPID RES 2002;43 (11):1899-1907 [PubMed]
Bisoendial RJ, Hovingh GK, de Groot E, Kastelein JJP, Lansberg PJ, Stroes ESG, Measurement of subclinical atherosclerosis: beyond risk factor assessment. CURR OPIN LIPIDOL 2002;13 (6):595-603 [PubMed]
Boekholdt SM, Trip MD, Peters RJG, Engelen M, Boer JMA, Feskens EJM, Zwinderman AH, Kastelein JJP, Reitsma PH, Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction. ARTERIOSCL THROM VAS 2002;22 (12):E24-E27 [PubMed]
Büller HR, Kastelein JJP, Stroes ESG, editors, Vasculaire geneeskunde. Alphen a/d Rijn: Van Zuiden communications; 2002. 356p. ISBN 90 76906 34 3
Büller HR, Kastelein JJP, Stroes ESG, editors, Vasculaire geneeskunde. S.l.: Van Zuiden Communications; 2002. -p.
de Beer F, Stalenhoef AFH, Hoogerbrugge N, Kastelein JJP, Gevers Leuven JA, van Duijn CM, Havekes LM, Smelt AHM, Expression of type III hyperlipoproteinemia in apolipoprotein E2 (Arg158 -> Cys) homozygotes is associated with hyperinsulinemia. ARTERIOSCL THROM VAS 2002;22 (2):294-299 [PubMed]
de Graaf J, de Sauvage Nolting PRW, van Dam M, Belsey EM, Kastelein JJP, Haydn Pritchard P, Stalenhoef AFH, Consumption of tall oil-derived phytosterols in a chocolate matrix significantly decreases plasma total and low-density lipoprotein-cholesterol levels. BRIT J NUTR 2002;88 (5):479-488 [PubMed]
de Grooth GJ, Kuivenhoven JA, Stalenhoef AFH, de Graaf J, Zwinderman AH, Posma JL, van Tol A, Kastelein JJP, Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans - A randomized phase II dose-response study. CIRCULATION 2002;105 (18):2159-2165 [PubMed]
de Jongh S. Familial hypercholesterolemia in childhood. S.l.: s.n.; 2002. 159p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP, Heymans HSA; copromotor(s): Bakker HD, Büller HR)
de Jongh S, Lilien MR, Bakker HD, Hutten BA, Kastelein JJP, Stroes ESG, Family history of cardiovascular events and endothelial dysfunction in children with familial hypercholesterolemia. ATHEROSCLEROSIS 2002;163 (1):193-197 [PubMed]
de Jongh S, Lilien MR, Op't Roodt J, Stroes ESG, Bakker HD, Kastelein JJP, Early statin therapy restores endothelial function in children with familial hypercholesterolemia. J AM COLL CARDIOL 2002;40 (12):2117-2121 [PubMed]
de Jongh S, Ose L, Szamosi T, Gagné C, Lambert M, Scott R, Perron P, Dobbelaere D, Saborio M, Tuohy MB, Stepanavage M, Sapre A, Gumbiner B, Mercuri M, van Trotsenburg ASP, Bakker HD, Kastelein JJP, Efficacy and safety of statin therapy in children with familial hypercholesterolemia - A randomized, double-blind, placebo-controlled trial with simvastatin. CIRCULATION 2002;106 (17):2231-2237 [PubMed]
de Jongh S, Stalenhoef AFH, Tuohy MB, Mercuri M, Bakker HD, Kastelein JJP, Efficacy, safety and tolerability of simvastatin in children with familial hypercholesterolaemia - Rationale, design and baseline characteristics. CLIN DRUG INVEST 2002;22 (8):533-540
de Sauvage Nolting PRW. Genetics and therapy of familial hypercholesterolemia. S.l.: s.n.; 2002. 173p. ISBN 90 6464 085 8 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP, Büller HR; copromotor(s): )
de Sauvage Nolting PRW, Buirma RJA, Hutten BA, Kastelein JJP, Baseline lipid values partly determine the response to high-dose simvastatin in patients with familial hypercholesterolemia - The examination of probands and relatives in Statin studies with familial hypercholesterolemia (ExPRESS FH). ATHEROSCLEROSIS 2002;164 (2):347-354 [PubMed]
de Sauvage Nolting PRW, Buirma RJA, Hutten BA, Kastelein JJP, Two-year efficacy and safety of Simvastatin 80 mg in familial hypercholesterolemia (The examination of probands and relatives in statin studies with familial hypercholesterolemia [ExPRESS FH]). AM J CARDIOL 2002;90 (2):181-+ [PubMed]
de Sauvage Nolting PRW, Twickler MB, Dallinga-Thie GM, Buirma RJA, Hutten BA, Kastelein JJP, Elevated remnant-like particles in heterozygous familial hypercholesterolemia and response to statin therapy. CIRCULATION 2002;106 (7):788-792 [PubMed]
Evans V, Kastelein JJP, Lipoprotein lipase deficiency - Rare or common?. CARDIOVASC DRUG THER 2002;16 (4):283-287 [PubMed]
Jansen ACM, van Wissen S, Defesche JC, Kastelein JJP, Phenotypic variability in familial hypercholesterolaemia: an update. CURR OPIN LIPIDOL 2002;13 (2):165-171 [PubMed]
Kastelein J, de Groot E, Zwinderman K, Arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux - Reply. LANCET 2002;359 (9325):2279
Maitland-van der Zee AH, Klungel OH, Stricker BHC, Verschuren WMM, Kastelein JJP, Leufkens HGM, de Boer A, Genetic polymorphisms: importance for response to HMG-CoA reductase inhibitors. ATHEROSCLEROSIS 2002;163 (2):213-222 [PubMed]
Maitland-van der Zee AH, Stricker BH, Klungel OH, Kastelein JJ, Hofman A, Witteman JC, Breteler MM, Leufkens HG, van Duijn CM, de Boer A, The effectiveness of hydroxy-methylglutaryl coenzyme A reductase inhibitors (statins) in the elderly is not influenced by apolipoprotein E genotype. PHARMACOGENETICS 2002;12 (8):647-653 [PubMed]
Trip MD. The spectrum of premature atherosclerosis: from single gene to complex genetic disorder. S.l.: s.n.; 2002. 248p. ISBN 90-9016460-X [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP; copromotor(s): Büller HR, Reitsma PH)
Trip MD, Smulders YM, Wegman JJ, Hu X, Boer JMA, ten Brink JB, Zwinderman AH, Kastelein JJP, Feskens EJM, Bergen AAB, Frequent mutation in the ABCC6 gene (R1141X) is associated with a strong increase in the prevalence of coronary artery disease. CIRCULATION 2002;106 (7):773-775 [PubMed]
Umans-Eckenhausen MAW. Genetic insights, clinical efficacy and practical implications of genetic screening for familial hypercholesterolemia. S.l.: s.n.; 2002. 165p. ISBN 90 5170 657 X [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Büller HR, Kastelein JJP; copromotor(s): Defesche JC)
Umans-Eckenhausen MAW, Oort FJ, Ferenschild KCMP, Defesche JC, Kastelein JJP, de Haes JCJM, Parental attitude towards genetic testing for familial hypercholesterolaemia in children. J MED GENET 2002;39 (9):e49 [PubMed]
Umans-Eckenhausen MAW, Sijbrands EJG, Kastelein JJP, Defesche JC, Low-density lipoprotein receptor gene mutations and cardiovascular risk in a large genetic cascade screening population. CIRCULATION 2002;106 (24):3031-3036 [PubMed]
van Dam MJ, de Groot E, Clee SM, Hovingh GK, Roelants R, Brooks-Wilson A, Zwinderman AH, Smit AJ, Smelt AHM, Groen AK, Hayden MR, Kastelein JJP, Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study. LANCET 2002;359 (9300):37-41 [PubMed]
van Dam MJ, Kastelein JJP, Treatment of hyperlipidemia with the statins: redefining what the statins can do. CARDIOVASC REV REP 2002;23:77-81, 84
van Dam M, van Wissen S, Kastelein JJP, Declaring war on undertreatment: rationale for an aggressive approach to lowering cholesterol. J CARDIOVASC RISK 2002;9 (2):89-95 [PubMed]
van Dam M, Zwart M, de Beer F, Smelt AHM, Prins MH, Trip MD, Havekes LM, Lansberg PJ, Kastelein JJP, Long term efficacy and safety of atorvastatin in the treatment of severe type III and combined dyslipidaemia. HEART 2002;88 (3):234-238 [PubMed]
van Wissen S, Trip MD, Smilde TJ, de Graaf J, Stalenhoef AFH, Kastelein JJP, Differential hs-CRP reduction in patients with familial hypercholesterolemia treated with aggressive or conventional statin therapy. ATHEROSCLEROSIS 2002;165 (2):361-366 [PubMed]
Wellington CL, Yang YZ, Zhou S, Clee SM, Tan B, Hirano K, Zwarts K, Kwok A, Gelfer A, Marcil M, Newman S, Roomp K, Singaraja R, Collins J, Zhang LH, Groen AK, Hovingh K, Brownlie A, Tafuri S, Genest J Jr, Kastelein JJP, Hayden MR, Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol. J LIPID RES 2002;43 (11):1939-1949 [PubMed]
Zwarts KY, Clee SM, Zwinderman AH, Engert JC, Singaraja R, Loubser O, James E, Roomp K, Hudson TJ, Jukema JW, Kastelein JJP, Hayden MR, ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels. CLIN GENET 2002;61 (2):115-125 [PubMed]
Agema WR, Jukema JW, Pimstone SN, Kastelein JJ, Genetic aspects of restenosis after percutaneous coronary interventions: towards more tailored therapy. EUR HEART J 2001;22 (22):2058-2074 [PubMed]
Attie AD, Kastelein JP, Hayden MR, Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis. J LIPID RES 2001;42 (11):1717-1726 [PubMed]
Boer JM, Feskens EJ, Kuivenhoven JA, Schouten EG, Havekes LM, Kastelein JJ, Seidell JC, Kromhout D, Parental history of myocardial infarction: lipid traits, gene polymorphisms and lifestyle. ATHEROSCLEROSIS 2001;155 (1):149-156 [PubMed]
Clee SM, Loubser O, Collins J, Kastelein JJ, Hayden MR, The LPL S447X cSNP is associated with decreased blood pressure and plasma triglycerides, and reduced risk of coronary artery disease. CLIN GENET 2001;60 (4):293-300 [PubMed]
Clee SM, Zwinderman AH, Engert JC, Zwarts KY, Molhuizen HO, Roomp K, Jukema JW, van Wijland M, van Dam M, Hudson TJ, Brooks-Wilson A, Genest J Jr, Kastelein JJ, Hayden MR, Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease. CIRCULATION 2001;103 (9):1198-1205 [PubMed]
Defesche JC, Kastelein JJP. Lipoproteins and atherosclerosis in: Doevendans PA, Wilde AA, editors. Cardiovascular genetics. Dordrecht: Kluwer Academic Publishers; 2001., p. 51-58
Doevendans PA, Jukema W, Spiering W, Defesche JC, Kastelein JJ, Molecular genetics and gene expression in atherosclerosis. INT J CARDIOL 2001;80 (2-3):161-172 [PubMed]
Fouchier SW, Defesche JC, Umans-Eckenhausen MW, Kastelein JP, The molecular basis of familial hypercholesterolemia in The Netherlands. HUM GENET 2001;109 (6):602-615 [PubMed]
Leus FR, Zwart M, Kastelein JJ, Voorbij HA, PON2 gene variants are associated with clinical manifestations of cardiovascular disease in familial hypercholesterolemia patients. ATHEROSCLEROSIS 2001;154 (3):641-649 [PubMed]
Sijbrands EJ, Westendorp RG, Defesche JC, de Meier PH, Smelt AH, Kastelein JJ, Mortality over two centuries in large pedigree with familial hypercholesterolaemia: family tree mortality study. BMJ-BRIT MED J 2001;322 (7293):1019-1023 [PubMed]
Smilde TJ, van Wissen S, Wollersheim H, Kastelein JJ, Stalenhoef AF, Genetic and metabolic factors predicting risk of cardiovascular disease in familial hypercholesterolemia. NETH J MED 2001;59 (4):184-195 [PubMed]
Smilde TJ, van Wissen S, Wollersheim H, Trip MD, Kastelein JJ, Stalenhoef AF, Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial. LANCET 2001;357 (9256):577-581 [PubMed]
ten Asbroek AH, de Mheen PJ, Defesche JC, Kastelein JJ, Gunning-Schepers LJ, Results from a family and DNA based active identification programme for familial hypercholesterolaemia. J EPIDEMIOL COMMUN H 2001;55 (7):500-502 [PubMed]
Umans-Eckenhausen MA, Defesche JC, Sijbrands EJ, Scheerder RL, Kastelein JJ, Review of first 5 years of screening for familial hypercholesterolaemia in the Netherlands. LANCET 2001;357 (9251):165-168 [PubMed]
van Dam MJ, Penn HJ, den Hartog FR, Kragten HA, Trip MD, Buirma RJ, Kastelein JJ, A comparison of the efficacy and tolerability of titrate-to-goal regimens of simvastatin and fluvastatin: a randomized, double-blind study in adult patients at moderate to high risk for cardiovascular disease. CLIN THER 2001;23 (3):467-478 [PubMed]
van der Valk M, Kastelein JJ, Murphy RL, van Leth F, Katlama C, Horban A, Glesby M, Behrens G, Clotet B, Stellato RK, Molhuizen HO, Reiss P, Nevirapine-containing antiretroviral therapy in HIV-1 infected patients results in an anti-atherogenic lipid profile. AIDS 2001;15 (18):2407-2414 [PubMed]
van Geel PP, Pinto YM, Zwinderman AH, Henning RH, van Boven AJ, Jukema JW, Bruschke AV, Kastelein JJ, van Gilst WH, Increased risk for ischaemic events is related to combined RAS polymorphism. HEART 2001;85 (4):458-462 [PubMed]
Clee SM, Bissada N, Miao F, Miao L, Marais AD, Henderson HE, Steures P, McManus J, McManus B, LeBoeuf RC, Kastelein JJ, Hayden MR, Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis. J LIPID RES 2000;41 (4):521-531 [PubMed]
Clee SM, Kastelein JJ, van Dam M, Marcil M, Roomp K, Zwarts KY, Collins JA, Roelants R, Tamasawa N, Stulc T, Suda T, Ceska R, Boucher B, Rondeau C, DeSouich C, Brooks-Wilson A, Molhuizen HO, Frohlich J, Genest J Jr, Hayden MR, Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes. J CLIN INVEST 2000;106 (10):1263-1270 [PubMed]
Davidson MH, Stein EA, Hunninghake DB, Ose L, Dujovne CA, Insull W Jr, Bertolami M, Weiss SR, Kastelein JJ, Scott RS, Campodónico S, Escobar ID, Schrott HG, Bays H, Stepanavage ME, Wu M, Tate AC, Melino MR, Kush D, Mercuri M, Mitchel YB, Lipid-altering efficacy and safety of simvastatin 80 mg/day: worldwide long-term experience in patients with hypercholesterolemia. NUTR METAB CARDIOVAS 2000;10 (5):253-262 [PubMed]
Hayden MR, Clee SM, Brooks-Wilson A, Genest J Jr, Attie A, Kastelein JJ, Cholesterol efflux regulatory protein, Tangier disease and familial high-density lipoprotein deficiency. CURR OPIN LIPIDOL 2000;11 (2):117-122 [PubMed]
Heikens J, Ubbink MC, van der Pal HP, Bakker PJ, Fliers E, Smilde TJ, Kastelein JJ, Trip MD, Long term survivors of childhood brain cancer have an increased risk for cardiovascular disease. CANCER-AM CANCER SOC 2000;88 (9):2116-2121 [PubMed]
Hoffer MJ, Snieder H, Bredie SJ, Demacker PN, Kastelein JJ, Frants RR, Stalenhoef AF, The V73M mutation in the hepatic lipase gene is associated with elevated cholesterol levels in four Dutch pedigrees with familial combined hyperlipidemia. ATHEROSCLEROSIS 2000;151 (2):443-450 [PubMed]
Jukema JW, Kastelein JJ, Tailored therapy to fit individual profiles. Genetics and coronary artery disease. ANN NY ACAD SCI 2000;902:17-24; discussion 24-6 [PubMed]
Kastelein JJ, Screening for familial hypercholesterolaemia. Effective, safe treatments and dna testing make screening attractive. BMJ-BRIT MED J 2000;321 (7275):1483-1484 [PubMed]
Kastelein JJ, Isaacsohn JL, Ose L, Hunninghake DB, Frohlich J, Davidson MH, Habib R, Dujovne CA, Crouse JR, Liu M, Melino MR, O'Grady L, Mercuri M, Mitchel YB, Comparison of effects of simvastatin versus atorvastatin on high-density lipoprotein cholesterol and apolipoprotein A-I levels. AM J CARDIOL 2000;86 (2):221-223 [PubMed]
Kastelein JJ, Jukema JW, Zwinderman AH, Clee S, van Boven AJ, Jansen H, Rabelink TJ, Peters RJ, Lie KI, Liu G, Bruschke AV, Hayden MR, Lipoprotein lipase activity is associated with severity of angina pectoris. REGRESS Study Group. CIRCULATION 2000;102 (14):1629-1633 [PubMed]
Khoo KL, van Acker P, Defesche JC, Tan H, van de Kerkhof L, Heijnen-van Eijk SJ, Kastelein JJ, Deslypere JP, Low-density lipoprotein receptor gene mutations in a Southeast Asian population with familial hypercholesterolemia. CLIN GENET 2000;58 (2):98-105 [PubMed]
Lansberg PJ, Tuzgöl S, van de Ree MA, Defesche JC, Kastelein JJ, Prevalentie van familiaire hypercholesterolemie onder volwassenen in vier huisartsenpraktijken hoger dan werd aangenomen. NED TIJDSCHR GENEESKD 2000;144 (30):1437-1440 [PubMed]
Leus FR, Wittekoek ME , Prins J, Kastelein JJ, Voorbij HA, Paraoxonase gene polymorphisms are associated with carotid arterial wall thickness in subjects with familial hypercholesterolemia. ATHEROSCLEROSIS 2000;149 (2):371-377 [PubMed]
Lombardi MP, Redeker EJ, Defesche JC, Kamerling SW, Trip MD, Mannens MM, Havekes LM, Kastelein JJ, Molecular genetic testing for familial hypercholesterolemia: spectrum of LDL receptor gene mutations in The Netherlands. CLIN GENET 2000;57 (2):116-124 [PubMed]
Ose L, Davidson MH, Stein EA, Kastelein JJ, Scott RS, Hunninghake DB, Campodonico S, Insull W, Escobar ID, Schrott HG, Stepanavage ME, Wu M, Tate AC, Melino MR, Mercuri M, Mitchel YB, Lipid-altering efficacy and safety of simvastatin 80 mg/day: long-term experience in a large group of patients with hypercholesterolemia. World Wide Expanded Dose Simvastatin Study Group. CLIN CARDIOL 2000;23 (1):39-46 [PubMed]
Sijbrands EJ, Westendorp RG, Paola Lombardi M, Havekes LM, Frants RR, Kastelein JJ, Smelt AH, Additional risk factors influence excess mortality in heterozygous familial hypercholesterolaemia. ATHEROSCLEROSIS 2000;149 (2):421-425 [PubMed]
Smilde TJ, Trip MD, Wollersheim H, van Wissen S, Kastelein JJ, Stalenhoef AF, Rationale, Design and Baseline Characteristics of a Clinical Trial Comparing the Effects of Robust vs Conventional Cholesterol Lowering and Intima Media Thickness in Patients with Familial Hypercholesterolaemia : The Atorvastatin versus Simvastatin on Atherosclerosis Progression (ASAP) Study. CLIN DRUG INVEST 2000;20 (2):67-79 [PubMed]
Smilde TJ, van den Berkmortel FW, Wollersheim H, van Langen H, Kastelein JJ, Stalenhoef AF, The effect of cholesterol lowering on carotid and femoral artery wall stiffness and thickness in patients with familial hypercholesterolaemia. EUR J CLIN INVEST 2000;30 (6):473-480 [PubMed]
Stalenhoef AF, de Graaf J, Wittekoek ME , Bredie SJ, Demacker PN, Kastelein JJ, The effect of concentrated n-3 fatty acids versus gemfibrozil on plasma lipoproteins, low density lipoprotein heterogeneity and oxidizability in patients with hypertriglyceridemia. ATHEROSCLEROSIS 2000;153 (1):129-138 [PubMed]
Trip MD, Lansberg PJ, de Jongh S, Kastelein JJ, Familiaire hypercholesterolemie: cardiovasculaire complicaties op jonge leeftijd te verwachten en te voorkomen. NED TIJDSCHR GENEESKD 2000;144 (30):1425-1428 [PubMed]
Boer JM, Kuivenhoven JA, Feskens EJ, Schouten EG, Havekes LM, Seidell JC, Kastelein JJ, Kromhout D, Physical activity modulates the effect of a lipoprotein lipase mutation (D9N) on plasma lipids and lipoproteins. CLIN GENET 1999;56 (2):158-163 [PubMed]
Brooks-Wilson A, Marcil M, Clee SM, Zhang LH, Roomp K, van Dam M, Yu L, Brewer C, Collins JA, Molhuizen HO, Loubser O, Ouelette BF, Fichter K, Ashbourne-Excoffon KJ, Sensen CW, Scherer S, Mott S, Denis M, Martindale D, Frohlich J, Morgan K, Koop B, Pimstone S, Kastelein JJ, Genest J Jr, Hayden MR, Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. NAT GENET 1999;22 (4):336-345 [PubMed]
de Maat MP, Jukema JW, Ye S, Zwinderman AH, Moghaddam PH, Beekman M, Kastelein JJ, van Boven AJ, Bruschke AV, Humphries SE, Kluft C, Henney AM, Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis. AM J CARDIOL 1999;83 (6):852-856 [PubMed]
Franco RF, Trip MD, ten Cate H, van den Ende A, Prins MH, Kastelein JJ, Reitsma PH, The 20210 G-->A mutation in the 3'-untranslated region of the prothrombin gene and the risk for arterial thrombotic disease. BRIT J HAEMATOL 1999;104 (1):50-54 [PubMed]
Gagné SE, Larson MG, Pimstone SN, Schaefer EJ, Kastelein JJ, Wilson PW, Ordovas JM, Hayden MR, A common truncation variant of lipoprotein lipase (Ser447X) confers protection against coronary heart disease: the Framingham Offspring Study. CLIN GENET 1999;55 (6):450-454 [PubMed]
Hallman DM, Groenemeijer BE, Jukema JW, Boerwinkle E, Kastelein JJ, Analysis of lipoprotein lipase haplotypes reveals associations not apparent from analysis of the constituent loci. ANN HUM GENET 1999;63 (Part 6):499-510 [PubMed]
Henderson HE, Kastelein JJ, Zwinderman AH, Gagné E, Jukema JW, Reymer PW, Groenemeyer BE, Lie KI, Bruschke AV, Hayden MR, Jansen H, Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins. J LIPID RES 1999;40 (4):735-743 [PubMed]
Kastelein JJ, The future of best practice. ATHEROSCLEROSIS 1999;143 (Suppl. 1):S17-S21 [PubMed]
Kastelein JJ, Ordovas JM, Wittekoek ME , Pimstone SN, Wilson WF, Gagné SE, Larson MG, Schaefer EJ, Boer JM, Gerdes C, Hayden MR, Two common mutations (D9N, N291S) in lipoprotein lipase: a cumulative analysis of their influence on plasma lipids and lipoproteins in men and women. CLIN GENET 1999;56 (4):297-305 [PubMed]
Marcil M, Brooks-Wilson A, Clee SM, Roomp K, Zhang LH, Yu L, Collins JA, van Dam M, Molhuizen HO, Loubster O, Ouellette BF, Sensen CW, Fichter K, Mott S, Denis M, Boucher B, Pimstone S, Genest J Jr, Kastelein JJ, Hayden MR, Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux. LANCET 1999;354 (9187):1341-1346 [PubMed]
Minnema MC, Wittekoek ME , Schoonenboom N, Kastelein JJ, Hack CE, ten Cate H, Activation of the contact system of coagulation does not contribute to the hemostatic imbalance in hypertriglyceridemia. ARTERIOSCL THROM VAS 1999;19 (10):2548-2553 [PubMed]
Umans-Eckenhausen MA, Defesche JC, Scheerder RL, Cliné F, Kastelein JJ, Opsporing van patiënten met familiaire hypercholesterolemie in Nederland. NED TIJDSCHR GENEESKD 1999;143 (22):1157-1161 [PubMed]
Verhaar MC, Honing ML, van Dam T, Zwart M, Koomans HA, Kastelein JJ, Rabelink TJ, Nifedipine improves endothelial function in hypercholesterolemia, independently of an effect on blood pressure or plasma lipids. CARDIOVASC RES 1999;42 (3):752-760 [PubMed]
Verhaar MC, Wever RM, Kastelein JJ, van Loon D, Milstien S, Koomans HA, Rabelink TJ, Effects of oral folic acid supplementation on endothelial function in familial hypercholesterolemia. A randomized placebo-controlled trial. CIRCULATION 1999;100 (4):335-338 [PubMed]
Wittekoek ME , de Groot E, Prins MH, Trip MD, Büller HR, Kastelein JJ, Differences in intima-media thickness in the carotid and femoral arteries in familial hypercholesterolemic heterozygotes with and without clinical manifestations of cardiovascular disease. ATHEROSCLEROSIS 1999;146 (2):271-279 [PubMed]
Wittekoek ME , Moll E, Pimstone SN, Trip MD, Lansberg PJ, Defesche JC, van Doormaal JJ, Hayden MR, Kastelein JJ, A frequent mutation in the lipoprotein lipase gene (D9N) deteriorates the biochemical and clinical phenotype of familial hypercholesterolemia. ARTERIOSCL THROM VAS 1999;19 (11):2708-2713 [PubMed]
Yu L, Heere-Ress E, Boucher B, Defesche JC, Kastelein J, Lavoie MA, Genest J Jr, Familial hypercholesterolemia. Acceptor splice site (G-->C) mutation in intron 7 of the LDL-R gene: alternate RNA editing causes exon 8 skipping or a premature stop codon in exon 8. LDL-R(Honduras-1) [LDL-R1061(-1) G-->C]. ATHEROSCLEROSIS 1999;146 (1):125-131 [PubMed]
Defesche JC, Kastelein JJ, Molecular epidemiology of familial hypercholesterolaemia. LANCET 1998;352 (9141):1643-1644 [PubMed]
de Maat MP, Kastelein JJ, Jukema JW, Zwinderman AH, Jansen H, Groenemeier B, Bruschke AV, Kluft C, -455G/A polymorphism of the beta-fibrinogen gene is associated with the progression of coronary atherosclerosis in symptomatic men: proposed role for an acute-phase reaction pattern of fibrinogen. REGRESS group. ARTERIOSCL THROM VAS 1998;18 (2):265-271 [PubMed]
Diekman T, Demacker PN, Kastelein JJ, Stalenhoef AF, Wiersinga WM, Increased oxidizability of low-density lipoproteins in hypothyroidism. J CLIN ENDOCR METAB 1998;83 (5):1752-1755 [PubMed]
Franco RF, Zago MA, Trip MD, ten Cate H, van den Ende A, Prins MH, Kastelein JJ, Reitsma PH, Prevalence of hereditary haemochromatosis in premature atherosclerotic vascular disease. BRIT J HAEMATOL 1998;102 (5):1172-1175 [PubMed]
Henderson HE, Bijvoet SM, Mannens MA, Bruin T, Erkelens DW, Hayden MR, Kastelein JJ, Ile225Thr loop mutation in the lipoprotein lipase (LPL) gene is a de novo event. AM J MED GENET 1998;78 (4):313-316 [PubMed]
Hoffer MJ, Bredie SJ, Snieder H, Reymer PW, Demacker PN, Havekes LM, Boomsma DI, Stalenhoef AF, Frants RR, Kastelein JJ, Gender-related association between the -93T-->G/D9N haplotype of the lipoprotein lipase gene and elevated lipid levels in familial combined hyperlipidemia. ATHEROSCLEROSIS 1998;138 (1):91-99 [PubMed]
Kastelein JJ, Groenemeyer BE, Hallman DM, Henderson H, Reymer PW, Gagné SE, Jansen H, Seidell JC, Kromhout D, Jukema JW, Bruschke AV, Boerwinkle E, Hayden MR, The Asn9 variant of lipoprotein lipase is associated with the -93G promoter mutation and an increased risk of coronary artery disease. The Regress Study Group. CLIN GENET 1998;53 (1):27-33 [PubMed]
Kuivenhoven JA, Jukema JW, Zwinderman AH, de Knijff P, McPherson R, Bruschke AV, Lie KI, Kastelein JJ, The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. The Regression Growth Evaluation Statin Study Group. NEW ENGL J MED 1998;338 (2):86-93 [PubMed]
Prins J, van der Hoek YY, Biesheuvel TH, Leus FR, van Rijn HJ, Kastelein JJ, The functional and clinical significance of the Met-->Thr substitution in Kringle IV type 10 of apolipoprotein(a). THROMB RES 1998;90 (3):125-130 [PubMed]
Rust S, Walter M, Funke H, von Eckardstein A, Cullen P, Kroes HY, Hordijk R, Geisel J, Kastelein J, Molhuizen HO, Schreiner M, Mischke A, Hahmann HW, Assmann G, Assignment of Tangier disease to chromosome 9q31 by a graphical linkage exclusion strategy. NAT GENET 1998;20 (1):96-98 [PubMed]
Verhaar MC, Wever RM, Kastelein JJ, van Dam T, Koomans HA, Rabelink TJ, 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. CIRCULATION 1998;97 (3):237-241 [PubMed]
Verhoeff BJ, Trip MD, Prins MH, Kastelein JJ, Reitsma PH, The effect of a common methylenetetrahydrofolate reductase mutation on levels of homocysteine, folate, vitamin B12 and on the risk of premature atherosclerosis. ATHEROSCLEROSIS 1998;141 (1):161-166 [PubMed]
von Eckardstein A, Chirazi A, Schuler-Lüttmann S, Walter M, Kastelein JJ, Geisel J, Real JT, Miccoli R, Noseda G, Höbbel G, Assmann G, Plasma and fibroblasts of Tangier disease patients are disturbed in transferring phospholipids onto apolipoprotein A-I. J LIPID RES 1998;39 (5):987-998 [PubMed]
von Eckardstein A, Huang Y, Kastelein JJ, Geisel J, Real JT, Kuivenhoven JA, Miccoli R, Noseda G, Assmann G, Lipid-free apolipoprotein (apo) A-I is converted into alpha-migrating high density lipoproteins by lipoprotein-depleted plasma of normolipidemic donors and apo A-I-deficient patients but not of Tangier disease patients. ATHEROSCLEROSIS 1998;138 (1):25-34 [PubMed]
Wittekoek ME , Pimstone SN, Reymer PW, Feuth L, Botma GJ, Defesche JC, Prins M, Hayden MR, Kastelein JJ, A common mutation in the lipoprotein lipase gene (N291S) alters the lipoprotein phenotype and risk for cardiovascular disease in patients with familial hypercholesterolemia. CIRCULATION 1998;97 (8):729-735 [PubMed]
Bakker HD, Wiegman A, Defesche JC, Kastelein JJ, Is opsporing en behandeling van familiaire hypercholesterolemie geïndiceerd bij kinderen?. NED TIJDSCHR GENEESKD 1997;141 (52):2548-2551 [PubMed]
de Maat MP, Knipscheer HC, Kastelein JJ, Kluft C, Modulation of plasma fibrinogen levels by ciprofibrate and gemfibrozil in primary hyperlipidaemia. THROMB HAEMOSTASIS 1997;77 (1):75-79 [PubMed]
Ehrenborg E, Clee SM, Pimstone SN, Reymer PW, Benlian P, Hoogendijk CF, Davis HJ, Bissada N, Miao L, Gagné SE, Greenberg LJ, Henry R, Henderson H, Ordovas JM, Schaefer EJ, Kastelein JJ, Kotze MJ, Hayden MR, Ethnic variation and in vivo effects of the -93t-->g promoter variant in the lipoprotein lipase gene. ARTERIOSCL THROM VAS 1997;17 (11):2672-2678 [PubMed]
Foubert L, Bruin T, de Gennes JL, Ehrenborg E, Furioli J, Kastelein J, Benlian P, Hayden M, A single Ser259Arg mutation in the gene for lipoprotein lipase causes chylomicronemia in Moroccans of Berber ancestry. HUM MUTAT 1997;10 (3):179-185 [PubMed]
Groenemeijer BE, Hallman MD, Reymer PW, Gagné E, Kuivenhoven JA, Bruin T, Jansen H, Lie KI, Bruschke AV, Boerwinkle E, Hayden MR, Kastelein JJ, Genetic variant showing a positive interaction with beta-blocking agents with a beneficial influence on lipoprotein lipase activity, HDL cholesterol, and triglyceride levels in coronary artery disease patients. The Ser447-stop substitution in the lipoprotein lipase gene. REGRESS Study Group. CIRCULATION 1997;95 (12):2628-2635 [PubMed]
Hansen PS, Defesche JC, Kastelein JJ, Gerdes LU, Fraza L, Gerdes C, Tato F, Jensen HK, Jensen LG, Klausen IC, Faergeman O, Schuster H, Phenotypic variation in patients heterozygous for familial defective apolipoprotein B (FDB) in three European countries. ARTERIOSCL THROM VAS 1997;17 (4):741-747 [PubMed]
Jansen H, Verhoeven AJ, Weeks L, Kastelein JJ, Halley DJ, van den Ouweland A, Jukema JW, Seidell JC, Birkenhäger JC, Common C-to-T substitution at position -480 of the hepatic lipase promoter associated with a lowered lipase activity in coronary artery disease patients. ARTERIOSCL THROM VAS 1997;17 (11):2837-2842 [PubMed]
Kluijtmans LA, Kastelein JJ, Lindemans J, Boers GH, Heil SG, Bruschke AV, Jukema JW, van den Heuvel LP, Trijbels FJ, Boerma GJ, Verheugt FW, Willems F, Blom HJ, Thermolabile methylenetetrahydrofolate reductase in coronary artery disease. CIRCULATION 1997;96 (8):2573-2577 [PubMed]
Knipscheer HC, Kindt I, van den Ende A, Nurmohamed MT, Smalbraak H, Mulder WJ, Kastelein JJ, Magnesium pyridoxal-5'-phosphate glutamate, "A vitamin B6 derivative", does not affect lipoprotein levels in patients with familial hypercholesterolaemia. EUR J CLIN PHARMACOL 1997;51 (6):499-503 [PubMed]
Kockx M, de Maat MP, Knipscheer HC, Kastelein JJ, Kluft C, Princen HM, Kooistra T, Effects of gemfibrozil and ciprofibrate on plasma levels of tissue-type plasminogen activator, plasminogen activator inhibitor-1 and fibrinogen in hyperlipidaemic patients. THROMB HAEMOSTASIS 1997;78 (4):1167-1172 [PubMed]
Kuivenhoven JA, de Knijff P, Boer JM, Smalheer HA, Botma GJ, Seidell JC, Kastelein JJ, Pritchard PH, Heterogeneity at the CETP gene locus. Influence on plasma CETP concentrations and HDL cholesterol levels. ARTERIOSCL THROM VAS 1997;17 (3):560-568 [PubMed]
Kuivenhoven JA, Groenemeyer BE, Boer JM, Reymer PW, Berghuis R, Bruin T, Jansen H, Seidell JC, Kastelein JJ, Ser447stop mutation in lipoprotein lipase is associated with elevated HDL cholesterol levels in normolipidemic males. ARTERIOSCL THROM VAS 1997;17 (3):595-599 [PubMed]
Kuivenhoven JA, Pritchard H, Hill J, Frohlich J, Assmann G, Kastelein J, The molecular pathology of lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes. J LIPID RES 1997;38 (2):191-205 [PubMed]
Lombardi P, Defesche JC, Kamerling SW, Kastelein JJ, Havekes LM, A novel mutation M-21V in exon 1 of the low density lipoprotein receptor gene causing familial hypercholesterolemia. CLIN GENET 1997;51 (6):430-431 [PubMed]
Lombardi P, Defesche JC, Kamerling SW, Kastelein JJ, Havekes LM, A novel V415A mutation in exon 9 of the low density lipoprotein receptor gene causing familial hypercholesterolemia. CLIN GENET 1997;51 (4):286-287 [PubMed]
Lookene A, Groot NB, Kastelein JJ, Olivecrona G, Bruin T, Mutation of tryptophan residues in lipoprotein lipase. Effects on stability, immunoreactivity, and catalytic properties. J BIOL CHEM 1997;272 (2):766-772 [PubMed]
Pimstone SN, Defesche JC, Clee SM, Bakker HD, Hayden MR, Kastelein JJ, Differences in the phenotype between children with familial defective apolipoprotein B-100 and familial hypercholesterolemia. ARTERIOSCL THROM VAS 1997;17 (5):826-833 [PubMed]
Prins J, Leus FR, van der Hoek YY, Kastelein JJ, Bouma BN, van Rijn HJ, The identification and significance of a Thr-->Pro polymorphism in kringle IV type 8 of apolipoprotein(a). THROMB HAEMOSTASIS 1997;77 (5):949-954 [PubMed]
Stroes E, Kastelein J, Cosentino F, Erkelens W, Wever R, Koomans H, Lüscher T, Rabelink T, Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. J CLIN INVEST 1997;99 (1):41-46 [PubMed]
van der Hoek YY, Lingenhel A, Kraft HG, Defesche JC, Kastelein JJ, Utermann G, Sib-pair analysis detects elevated Lp(a) levels and large variation of Lp(a) concentration in subjects with familial defective ApoB. J CLIN INVEST 1997;99 (9):2269-2273 [PubMed]
van der Hoek YY, Wanders RJ, van den Ende AE, Kraft HG, Gabel BR, Kastelein JJ, Koschinsky ML, Lipoprotein[a] is not present in the plasma of patients with some peroxisomal disorders. J LIPID RES 1997;38 (8):1612-1619 [PubMed]
Bijvoet S, Gagné SE, Moorjani S, Gagné C, Henderson HE, Fruchart JC, Dallongeville J, Alaupovic P, Prins M, Kastelein JJ, Hayden MR, Alterations in plasma lipoproteins and apolipoproteins before the age of 40 in heterozygotes for lipoprotein lipase deficiency. J LIPID RES 1996;37 (3):640-650 [PubMed]
Bijvoet SM, Wiebusch H, Ma Y, Reymer PW, Bruin T, Bakker HD, Funke H, Assmann G, Hayden MR, Kastelein JJ, Compound heterozygosity for a known and a novel defect in the lipoprotein lipase gene (Asp250-->Asn; Ser251-->Cys) resulting in lipoprotein lipase (LPL) deficiency. NETH J MED 1996;49 (5):189-195 [PubMed]
Bredie SJ, Westerveld HT, Knipscheer HC, de Bruin TW, Kastelein JJ, Stalenhoef AF, Effects of gemfibrozil or simvastatin on apolipoprotein-B-containing lipoproteins, apolipoprotein-CIII and lipoprotein(a) in familial combined hyperlipidaemia. NETH J MED 1996;49 (2):59-67 [PubMed]
Defesche JC, van Diermen DE, Hayden MR, Kastelein JP, Origin and migration of an Afrikaner founder mutation FHAfrikaner-2 (V408M) causing familial hypercholesterolemia. GENE GEOGR 1996;10 (1):1-10 [PubMed]
Hoffer MJ, Bredie SJ, Boomsma DI, Reymer PW, Kastelein JJ, de Knijff P, Demacker PN, Stalenhoef AF, Havekes LM, Frants RR, The lipoprotein lipase (Asn291-->Ser) mutation is associated with elevated lipid levels in families with familial combined hyperlipidaemia. ATHEROSCLEROSIS 1996;119 (2):159-167 [PubMed]
Jukema JW, van Boven AJ, Groenemeijer B, Zwinderman AH, Reiber JH, Bruschke AV, Henneman JA, Molhoek GP, Bruin T, Jansen H, Gagné E, Hayden MR, Kastelein JJ, The Asp9 Asn mutation in the lipoprotein lipase gene is associated with increased progression of coronary atherosclerosis. REGRESS Study Group, Interuniversity Cardiology Institute, Utrecht, The Netherlands. Regression Growth Evaluation Statin Study. CIRCULATION 1996;94 (8):1913-1918 [PubMed]
Knipscheer HC, Boelen CC, Kastelein JJ, van Diermen DE, Groenemeijer BE, van den Ende A, Büller HR, Bakker HD, Short-term efficacy and safety of pravastatin in 72 children with familial hypercholesterolemia. PEDIATR RES 1996;39 (5):867-871 [PubMed]
Knipscheer HC, de Valois JC, van den Ende B, ten Cate JW, Kastelein JJ, Ciprofibrate versus gemfibrozil in the treatment of primary hyperlipidaemia. ATHEROSCLEROSIS 1996;124 (Suppl):S75-S81 [PubMed]
Kuivenhoven JA, Stalenhoef AF, Hill JS, Demacker PN, Errami A, Kastelein JJ, Pritchard PH, Two novel molecular defects in the LCAT gene are associated with fish eye disease. ARTERIOSCL THROM VAS 1996;16 (2):294-303 [PubMed]
Kuivenhoven JA, Weibusch H, Pritchard PH, Funke H, Benne R, Assmann G, Kastelein JJ, An intronic mutation in a lariat branchpoint sequence is a direct cause of an inherited human disorder (fish-eye disease). J CLIN INVEST 1996;98 (2):358-364 [PubMed]
Lombardi P, Kamerling SW, Defesche JC, Kastelein JJ, Havekes LM, Identification of a double mutation in the low-density lipoprotein receptor gene causing familial hypercholesterolemia. CLIN GENET 1996;50 (6):525-526 [PubMed]
van den Ende A, van der Hoek YY, Kastelein JJ, Koschinsky ML, Labeur C, Rosseneu M, Lipoprotein [a]. ADV CLIN CHEM 1996;32:73-134 [PubMed]
Wiebusch H, Funke H, Bruin T, Bucher H, von Eckardstein A, Kastelein JJ, Assmann G, Compound heterozygosity for a known (D250N) and a novel (E410K) missense mutation in the C-terminal domain of lipoprotein lipase causes familial chylomicronemia. HUM MUTAT 1996;8 (4):381-383 [PubMed]
Bredie SJ, de Bruin TW, Demacker PN, Kastelein JJ, Stalenhoef AF, Comparison of gemfibrozil versus simvastatin in familial combined hyperlipidemia and effects on apolipoprotein-B-containing lipoproteins, low-density lipoprotein subfraction profile, and low-density lipoprotein oxidizability. AM J CARDIOL 1995;75 (5):348-353 [PubMed]
Diekman T, Lansberg PJ, Kastelein JJ, Wiersinga WM, Prevalence and correction of hypothyroidism in a large cohort of patients referred for dyslipidemia. ARCH INTERN MED 1995;155 (14):1490-1495 [PubMed]
Kuivenhoven JA, van Voorst tot Voorst EJ, Wiebusch H, Marcovina SM, Funke H, Assmann G, Pritchard PH, Kastelein JJ, A unique genetic and biochemical presentation of fish-eye disease. J CLIN INVEST 1995;96 (6):2783-2791 [PubMed]
Lansberg PJ, Mitchel YB, Shapiro D, Kastelein JJ, Altman R, Jerums G, Bolzano K, Giannini S, Davignon J, DeWailly P, Long-term efficacy and tolerability of simvastatin in a large cohort of elderly hypercholesterolemic patients. ATHEROSCLEROSIS 1995;116 (2):153-162 [PubMed]
Lombardi P, Sijbrands EJ, van de Giessen K, Smelt AH, Kastelein JJ, Frants RR, Havekes LM, Mutations in the low density lipoprotein receptor gene of familial hypercholesterolemic patients detected by denaturing gradient gel electrophoresis and direct sequencing. J LIPID RES 1995;36 (4):860-867 [PubMed]
Pimstone SN, Gagné SE, Gagné C, Lupien PJ, Gaudet D, Williams RR, Kotze M, Reymer PW, Defesche JC, Kastelein JJ, Mutations in the gene for lipoprotein lipase. A cause for low HDL cholesterol levels in individuals heterozygous for familial hypercholesterolemia. ARTERIOSCL THROM VAS 1995;15 (10):1704-1712 [PubMed]
Reymer PW, Gagné E, Groenemeyer BE, Zhang H, Forsyth I, Jansen H, Seidell JC, Kromhout D, Lie KE, Kastelein J, A lipoprotein lipase mutation (Asn291Ser) is associated with reduced HDL cholesterol levels in premature atherosclerosis. NAT GENET 1995;10 (1):28-34 [PubMed]
Reymer PW, Groenemeyer BE, van de Burg R, Kastelein JJ, Apolipoprotein E genotyping on agarose gels. CLIN CHEM 1995;41 (7):1046-1047 [PubMed]
Zhang H, Reymer PW, Liu MS, Forsythe IJ, Groenemeyer BE, Frohlich J, Brunzell JD, Kastelein JJ, Hayden MR, Ma Y, Patients with apoE3 deficiency (E2/2, E3/2, and E4/2) who manifest with hyperlipidemia have increased frequency of an Asn 291-->Ser mutation in the human LPL gene. ARTERIOSCL THROM VAS 1995;15 (10):1695-1703 [PubMed]
Bijvoet SM, Bruin T, Tuzgöl S, Bakker HD, Hayden MR, Kastelein JJ, Homozygosity for a mutation in the lipoprotein lipase gene (Gly139-->Ser) causes chylomicronaemia in a boy of Spanish descent. HUM GENET 1994;93 (3):339-343 [PubMed]
Bruin T, Groot NB, Jansen J, Kastelein JJ, The C-terminus of lipoprotein lipase is essential for biological function but contains no domain for glycosylphosphatidylinositol anchoring. EUR J BIOCHEM 1994;221 (3):1019-1025 [PubMed]
Bruin T, Tuzgöl S, Mulder WJ, van den Ende AE, Jansen H, Hayden MR, Kastelein JJ, A compound heterozygote for lipoprotein lipase deficiency, Val69-->Leu and Gly188-->Glu: correlation between in vitro LPL activity and clinical expression. J LIPID RES 1994;35 (3):438-445 [PubMed]
de Knijff P, van den Maagdenberg AM, Boomsma DI, Stalenhoef AF, Smelt AH, Kastelein JJ, Marais AD, Frants RR, Havekes LM, Variable expression of familial dysbetalipoproteinemia in apolipoprotein E*2 (Lys146-->Gln) Allele carriers. J CLIN INVEST 1994;94 (3):1252-1262 [PubMed]
Knipscheer HC, Nurmohamed MT, van den Ende A, Plaat B, Pruijs HJ, Mulder WJ, Kastelein JJ, Gemfibrozil treatment of the high triglyceride-low high-density lipoprotein cholesterol trait in men with established atherosclerosis. J INTERN MED 1994;236 (4):377-384 [PubMed]
Lansberg PJ, Knipscheer HC, Kastelein JJ, Prins MH, van der Ende AE, The effect of Fiberform, a low-phytate wheat fibre, on plasma lipids and blood pressure of women with familial hypercholesterolaemia. J INTERN MED 1994;236 (4):477-478 [PubMed]
Stalenhoef AF, Defesche JC, Kleinveld HA, Demacker PN, Kastelein JJ, Decreased resistance against in vitro oxidation of LDL from patients with familial defective apolipoprotein B-100. ARTERIOSCLER THROMB 1994;14 (3):489-493 [PubMed]
Tuzgöl S, Bijvoet SM, Bruin T, Kastelein JJ, Hayden MR, Apolipoprotein CII-Padova (Tyr37-->stop) as a cause of chylomicronaemia in an Italian kindred from Siculiana. J MED GENET 1994;31 (8):622-626 [PubMed]
van den Broek AJ, Hollaar L, Schaefer HI, van der Laarse A, Schuster H, Defesche JC, Kastelein JJ, van 't Hooft FM, Screening for familial defective apolipoprotein B-100 with improved U937 monocyte proliferation assay. CLIN CHEM 1994;40 (3):395-399 [PubMed]
van der Hoek YY, Kastelein JJ, Koschinsky ML, Analysis of structure--function relationships in human apolipoprotein(a). CAN J PHYSIOL PHARM 1994;72 (3):304-310 [PubMed]
van der Hoek YY, Sangrar W, Côté GP, Kastelein JJ, Koschinsky ML, Binding of recombinant apolipoprotein(a) to extracellular matrix proteins. ARTERIOSCLER THROMB 1994;14 (11):1792-1798 [PubMed]
Bijvoet SM, Bruin T, Kastelein JJ, The familial hyperchylomicronaemia syndrome. NETH J MED 1993;42 (1-2):36-44 [PubMed]
Bruin T, Tuzgöl S, van Diermen DE, Hoogerbrugge-van der Linden N, Brunzell JD, Hayden MR, Kastelein JJ, Recurrent pancreatitis and chylomicronemia in an extended Dutch kindred is caused by a Gly154-->Ser substitution in lipoprotein lipase. J LIPID RES 1993;34 (12):2109-2119 [PubMed]
Defesche JC, Lansberg PJ, Reymer PW, Lamping RJ, Kastelein JJ, Analysis of the Afrikaner mutation in exon 9 of the low-density lipoprotein receptor gene in a large Dutch kindred suffering from familial hypercholesterolaemia. NETH J MED 1993;42 (1-2):53-60 [PubMed]
Defesche JC, Pricker KL, Hayden MR, van der Ende BE, Kastelein JJ, Familial defective apolipoprotein B-100 is clinically indistinguishable from familial hypercholesterolemia. ARCH INTERN MED 1993;153 (20):2349-2356 [PubMed]
Defesche JC, van Diermen DE, Lansberg PJ, Lamping RJ, Reymer PW, Hayden MR, Kastelein JJ, South African founder mutations in the low-density lipoprotein receptor gene causing familial hypercholesterolemia in the Dutch population. HUM GENET 1993;92 (6):567-570 [PubMed]
Hayden MR, Kastelein JJ, Funke H, Brunzell JD, Ma Y, Phenotypic variation of mutations in the human lipoprotein-lipase gene. BIOCHEM SOC T 1993;21 (2):506-509 [PubMed]
Henderson HE, Ma Y, Liu MS, Clark-Lewis I, Maeder DL, Kastelein JJ, Brunzell JD, Hayden MR, Structure-function relationships of lipoprotein lipase: mutation analysis and mutagenesis of the loop region. J LIPID RES 1993;34 (9):1593-1602 [PubMed]
Stalenhoef AF, Lansberg PJ, Kroon AA, Kortmann B, de Haan AF, Stuyt PM, Kastelein JJ, Treatment of primary hypercholesterolaemia. Short-term efficacy and safety of increasing doses of simvastatin and pravastatin: a double-blind comparative study. J INTERN MED 1993;234 (1):77-82 [PubMed]
van der Hoek YY, Wittekoek ME , Beisiegel U, Kastelein JJ, Koschinsky ML, The apolipoprotein(a) kringle IV repeats which differ from the major repeat kringle are present in variably-sized isoforms. HUM MOL GENET 1993;2 (4):361-366 [PubMed]
Bruin T, Kastelein JJ, van Diermen DE, Ma Y, Henderson HE, Stuyt PM, Stalenhoef AF, Sturk A, Brunzell JD, Hayden MR, A missense mutation Pro157 Arg in lipoprotein lipase (LPLNijmegen) resulting in loss of catalytic activity. EUR J BIOCHEM 1992;208 (2):267-272 [PubMed]
Defesche JC, van de Ree MA, Kastelein JJ, van Diermen DE, Janssens NW, van Doormaal JJ, Hayden MR, Detection of the Pro664-Leu mutation in the low-density lipoprotein receptor and its relation to lipoprotein(a) levels in patients with familial hypercholesterolemia of Dutch ancestry from The Netherlands and Canada. CLIN GENET 1992;42 (6):273-280 [PubMed]
Dekker E, Büller HR, Kastelein JJ, Postmenopauzale oestrogeensubstitutie en het risico van atherosclerotische hart- en vaatziekten. NED TIJDSCHR GENEESKD 1992;136 (25):1197-1200 [PubMed]
Kastelein JJ, Pritchard PH, Erkelens DW, Kuivenhoven JA, Albers JJ, Frohlich JJ, Familial high-density-lipoprotein deficiency causing corneal opacities (fish eye disease) in a family of Dutch descent. J INTERN MED 1992;231 (4):413-419 [PubMed]
Lansberg PJ, Kastelein JJ, Defesche JC, ten Cate JW, De behandeling van familiaire hypercholesterolemie. NED TIJDSCHR GENEESKD 1992;136 (15):734-738 [PubMed]
Ma YH, Bruin T, Tuzgol S, Wilson BI, Roederer G, Liu MS, Davignon J, Kastelein JJ, Brunzell JD, Hayden MR, Two naturally occurring mutations at the first and second bases of codon aspartic acid 156 in the proposed catalytic triad of human lipoprotein lipase. In vivo evidence that aspartic acid 156 is essential for catalysis. J BIOL CHEM 1992;267 (3):1918-1923 [PubMed]
Ma Y, Wilson BI, Bijvoet S, Henderson HE, Cramb E, Roederer G, Ven Murthy MR, Julien P, Bakker HD, Kastelein JJ, A missense mutation (Asp250----Asn) in exon 6 of the human lipoprotein lipase gene causes chylomicronemia in patients of different ancestries. GENOMICS 1992;13 (3):649-653 [PubMed]
Top B, Uitterlinden AG, van der Zee A, Kastelein JJ, Leuven JA, Havekes LM, Frants RR, Absence of mutations in the promoter region of the low density lipoprotein receptor gene in a large number of familial hypercholesterolaemia patients as revealed by denaturing gradient gel electrophoresis. HUM GENET 1992;89 (5):561-565 [PubMed]
Bakker HD, Bruin T, Schaap MC, Lansberg PJ, Kastelein JJ, The prediction of the therapeutic response to cholesterol lowering drugs in an 11-year-old boy with homozygous familial hypercholesterolaemia. J INHERIT METAB DIS 1991;14 (3):389-392 [PubMed]
Bruin T, Reymer PW, Groenemeyer BE, Talmud PJ, Kastelein JJ, HindIII-polymorphism in the LPL-gene detected by PCR. NUCLEIC ACIDS RES 1991;19 (22):6346 [PubMed]
Key publications

Robinson JG, Farnier M, Krempf M, Bergeron J, Luc G, Averna M, Stroes ES, Langslet G, Raal FJ, El Shahawy M, Koren MJ, Lepor NE, Lorenzato C, Pordy R, Chaudhari U, Kastelein JJP [Contributors: Caccavo A, Codutti O, Gelersztein E, Vico M, Zaidman C, Majul C, Balthazar Y, Capiau L, Vrolix M, Vermeersch P, Gotchev D, Todorov G, Tumbev H, Tzekova M, Gronkova N, Dimov B, Nikolaeva A, Devedzhiev T, Mincheva V, D'Ignazio G, Dzongowski P, Elliott T, Hart R, Hoag G, Martinho V, O'Mahony M, Tellier G, Bergeron J, Pandey S, Heaton K, Constance C, Phaneuf DC, Shu D, Narvaez NC, Cañon CO, Cardenas SP, Loayza MS, de Salazar DM, Lopez RB, Gomez JI, Mendoza JA, Cure CC, Ceska R, Zidkova E, Jansky P, Egstrup K, Klausen IBC, Lomholdt J, Gislason G, Torp-Pedersen C, Poulsen S, Kuusela M, Kekki S, Nieminen S, Tuomilehto J, Boye A, Bruckert E, Cadinot D, Farnier M, Lejay D, Luc G, Revol T, Schaupp T, Krempf M, Bonnet J, Paillard F, Moulin P, Junggeburth J, Isermann B, Zühlke M, Züchner D, Theis E, Stößel J, König HJ, Rinke A, Piechatzek R, Contzen C, Lappo M, Himpel-Boenninghoff AA, Meissner G, Maus O, Degtyareva E, Schulze ED, Horacek T, Marten I, Becher P, Matoltsy A, Nyirati G, Paragh G, Zilahi Z, Nagy K, Kanakaridisz N, Beke E, Biro J, Schnabel R, Elias M, Gavish D, Francis A, Nseir W, Zimlichman R, Averna M, Pozzi C, Lembo G, Bucci M, Mezzetti A, Rubba P, de Pellegrin AM, Salvioni A, de Cesare N, Briones IR, Campos PF, Rosas EL, Espinosa EV, Salazar MA, Ruiz AB, Furusho LC, Olvera I, Stroes E, van den Berg R, Basart D, Köse V, Kentgens S, Peeters M, Hoogendijk J, Voors-Pette C, Agous I, van Kempen W, Lingan GR, Kooy A, Troquay R, Herrman J, Hoivik H, Langslet G, Norheim P, Risberg K, Høivik HO, Elle S, Derezinski T, Miekus P, Ogorek M, Szymkowiak K, Cesar M, Gawron A, Dabrowska M, Blach E, Konieczny M, Sidor M, Matias F, da Silva PM, Carvalho D, Mendonca I, Andor M, Andrei L, Podoleanu C, Pop C, Chizhov P, Chumakova G, Goloschekin B, Libov I, Paltsman Z, Strutinskiy A, Koziolova N, Breedt J, Ebrahim I, Ellis G, Fulat M, van Rensburg DJ, Raal F, van Dyk C, Vally T, van der Walt E, Kotzé H, Landman C, Tayob M, Caixas A, García LR, Fernandez-Cruz A, Gil-Extremera B, Grijalvo OM, Plana N, Fuentes F, Valdivielso P, Fraile B, Borgencrantz B, Larnefeldt H, Tengmark BO, Eriksson M, Olsson-Önerud Å, Amalyan W, Dyadyk O, Koval O, Kushnir M, Svintsitskiy A, Kovalyov O, Bondarchuk O, Tashchuk V, Barna O, Prokhorov O, Karpenko O, Stanciu D, Pawa R, Balaji H, Doig F, Harvey P, Ranganath L, Massalski W, Hassanin H, Timmis H, Pavel-Knox I, Abdulhakim E, Oyesile B, Horvathova V, Donnachie H, Kondagunta V, Shaw H, Thomas H, Kadr H, Gunstone A, Lip G, Ellery A, Kerrane J, Sarker A, Wong Yk, Soran H, Maw K, Andersen J, Blair-Britt L, Huffman C, Kivitz A, Marple R, Patron A, Schear M, Allegar N, Awasty V, Casanova R, Chaykin L, Cohen L, Collins H, Collins G, Elkin G, Reyes H, Feld L, Fuller G, Glover R, Greenwald J, Herrod J, Kaye W, Kimmel M, Kolettis E, Lakin G, Lorch D, Palatnik M, Patel R, Reichman A, Rohlf J, Shockey G, Shore K, Radin D, Alvarado O, Bellingar B, Egelhof R, McKnight T, Plevin S, Pritchard J, Reddy R, Velazquez F, Bolster E, Broker R, Butuk D, Cheung D, Cohen K, Golden G, Murray A, Naccarato T, Uusinarkaus K, Pudi K, Graff A, Blumberg V, Dunn F, Toth P, Anspach R, Chuang R, Meli J, Nevins B, Wayne J, Schmidt L, Levinsky D, Rubino J, Shealy N, Torres D, West J, Jain R, Vardi G, Singh N, Thew S, Lo E, Heitner J, Gerber J, Malik A, Weinstein D, Prashad R, Koren M, Ghitis A, David W, Reis G, Kinzfogl G, Haught H, Kantaros L, O'dea D, Weiss D, Kassas S, Hunter J, Mollod M, Khan N, Henderson D, Gatien L, Schramm R, Madder R, El Shahawy M, Voyce S, Nadar V, Stich M, Kumar M, Black R, Treasure C, Lebeis M, McCullough P, Lepor N, Moriarty P, Waxler A, Talreja D, Gen M, Dohad S, East C, Conrad G, Asbill B, Roberts J, Robinson J, Zarich S, Davis B, Krolick M, Sherman H, Thompson P]] , Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events. NEW ENGL J MED 2015;372 (16):1489-1499 [PubMed]
Hovingh GK, Kastelein JJP, van Deventer SJH, Round P, Ford J, Saleheen D, Rader DJ, Brewer HB, Barter PJ, Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial. LANCET 2015;386 (9992):452-460 [PubMed]
Kastelein JJP, Besseling J, Shah S, Bergeron J, Langslet G, Hovingh GK, Al-Saady N, Koeijvoets M, Hunter J, Johnson-Levonas AO, Fable J, Sapre A, Mitchel Y, Anacetrapib as lipid-modifying therapy in patients with heterozygous familial hypercholesterolaemia (REALIZE): a randomised, double-blind, placebo-controlled, phase 3 study. LANCET 2015;385 (9983):2153-2161 [PubMed]
Gaudet D, Alexander VJ, Baker BF, Brisson D, Tremblay K, Singleton W, Geary RS, Hughes SG, Viney NJ, Graham MJ, Crooke RM, Witztum JL, Brunzell JD, Kastelein JJP, Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia. NEW ENGL J MED 2015;373 (5):438-447 [PubMed]


All Publications

Curriculum Vitae

 Biography Prof. John J.P. Kastelein, MD PhD FESC

 

John J.P. Kastelein (1954) is Professor of Medicine at the Department of Vascular Medicine at the Academic Medical Center (AMC) of the University of Amsterdam, where he holds the Strategic Chair of Genetics of Cardiovascular Disease. Professor Kastelein has published over 820 research papers in peer reviewed journals, including Nature Genetics, Lancet, New England Journal of Medicine, JAMA and Circulation and has a Hirsch index of 99 in July 2016. His overall citatitions reached 45655 in July 2016 and were 5314 over the year 2015. He is listed among the 3000 Highly Cited Researchers 2015; Dr. Kastelein is on the 10th position for the Netherlands and on the 2nd position for the Unviversity of Amsterdam.

 

He received his medical degree in Amsterdam in 1980 where he subsequently received specialty training in internal medicine. Then, between 1986 and 1988, he was trained in medical genetics, lipidology and molecular biology at the University of British Columbia, Vancouver under the guidance of Prof. Dr. M.R. Hayden. In 1997 and 1998 he served a visiting Professorship at the Center for Molecular Medicine and Therapeutics at the University of British Columbia, Vancouver, Canada. Upon his return to the Netherlands, he was awarded a doctorate (Cum Laude) and in 1989 he founded the Lipid Research Clinic at the Academic Medical Center, AMC) in Amsterdam, which is currently serving as a tertiary referral centre and has become part of the department of Vascular Medicine.

The most important concept in Dr. Kastelein’s research career, developed initially at the University of British Columbia, by his mentor Dr. Hayden, and subsequently transformed into practice at the AMC in Amsterdam, the Netherlands, is the “extreme genetics” approach. This approach teaches that the study of rare human disorders that are associated with premature coronary disease have broader relevance for the understanding of the etiology of heart disease in general and will yield therapeutic targets that are valid for all patients.

This approach has been very successful, in so far that Familial Hypercholesterolemia is now internationally recognized as the paradigm for the relationship between LDL-C and heart disease, a relationship substantiated by at least 50 peer reviewed manuscripts and 10 postdoctoral theses in Dr. Kastelein’s curriculum vitae.

The same “extreme genetics” concept was applied to disorders of HDL-C and elevated triglycerides and lead to the discovery of the cholesterol efflux protein ABCA1 and later to gene therapy for lipoprotein lipase deficiency. These two innovative contributions to science have lead to important breakthroughs in the field of drug development for the prevention of cardiovascular disease (development of ABCA1 agonists) and in the area of gene therapy for hereditary disorders such as haemophilia, LCAT deficiency and others.

In 1995, Dr. Kastelein initiated a foundation for the active identification of patients with classical familial hypercholesterolaemia (FH) in the Netherlands (StoeH), for which he currently holds a position in the board of directors. This program has now been fully institutionalized and is operational under supervision of the RijksInstituut voor Volksgezondheid en Milieu (RIVM) and financially supported by the Ministry of Health with a total grant of approximately 30 million Euros. Since its inception, the StoeH has found over 25.000 individuals for whom a molecular diagnosis of FH could be made. The subsequent improvement of the treatment of these FH patients has saved many lives, as published in Lancet in 2001 and in the British Medical Journal in 2008.

Dr. Kastelein was president of the Dutch Atherosclerosis Society (DAS) and chairs the National Scientific Committee on Familial Hypercholesterolemia (EHC). He also is a member of the Royal Dutch Society for Medicine & Physics, the Council for Basic Science of the American Heart Association and the European Atherosclerosis Society and a Fellow of the European Society of Cardiology. He also is a boardmember of the International Task Force for CHD Prevention and was recently appointed to the Executive Board of the International Atherosclerosis Society (IAS) and is a recognized world leader in the significance of lipoprotein metabolism for the development of atherosclerotic vascular disease.

Dr. Kastelein was a principal investigator of the Bloodomics and CardioGenics consortia, two large European Union supported endavours under the Framework Programme 7, that aim to elucidate the molecular basis of atherosclerosis and premature coronary disease. Besides the scientific programmes aimed at the etiology of atherogenesis, Dr. Kastelein also served on a number of executive and steering committees of large cardiovascular intervention studies, including the IDEAL, TNT, CAPTIVATE, ENHANCE, ILLUMINATE, JUPITER, RADIANCE and numerous others of which TNT (2005), RADIANCE 1 (2007), ENHANCE (2008) and JUPITER (2008) are published in the New England Journal of Medicine, IDEAL (2006) in JAMA and RADIANCE 2 (2007) in Lancet.

Dr. Kastelein has directed 55 postdoctoral theses and currently, he works in a team of 7 internists, 6 postdoctoral fellows, 26 MD PhD students, and a large number of laboratory technicians and clinical trial / study coordinators

Dr. Kastelein is invited regularly to important meetings on vascular disease for invited or keynote lectures, at least 5 meetings per year (American Heart Association, American College of Cardiology, European Society of Cardiology, International Atherosclerosis Society, European Atherosclerosis Society, etc.). Overall, his invited lectures can be numbered in hundreds.

Dr. Kastelein was in 1997 a co-founder of Xenon Genetics Inc., a drug discovery company that has now changed its name into Xenon Pharmaceuticals Inc., listed on the Nasdaq, and is based in Vancouver, Canada. One of Dr. Kastelein’s concepts of using “extreme genetics” to clone human validated disease genes that can than be turned into useful therapeutic targets, was an important basis for the rise of Xenon and also lead to the cloning of the ATP-binding cassette A1 (ABCA1) gene, as published in Nature Genetics 1999.

Professor Kastelein was also one of the founders of Amsterdam Molecular Therapeutics Inc. (AMT), a gene therapy company based on the concept of gene replacement in hereditary lipoprotein disorders. AMT has enjoyed a successful Initial Public Offering (IPO) at EuroNext in Amsterdam in the summer of 2007. The results of the first successful human gene therapy trial were widely publicized in the media and are published in ATVB in 2008. Furthermore, this gene therapy (Glybera) has now been approved by the European commission and constitutes the first approved gene therapy worldwide. Amsterdam Molecular Therapeutics has now changed its name into UniQure, listed on the Nasdaq, and Prof. Kastelein is the major consultant for Glybera. The review article on the history of Glybera as published in Human Gene Therapy in 2013 belonged to the 10 most referenced manuscripts in this journal.

Recently, Prof. Kastelein also founded Dezima Inc, a pharmaceutical company that develops assets for the treatment of dyslipidemia and has developed a cholesteryl ester transfer protein (CETP) inhibitor DEZ-001 (formerly TA-8995), inlicensed from Mitsubishi Tanabe Pharma Corporation (MTPC). Dezima Pharma was acquired by Amgen in 2015 in one of the largest private equity deals in biotechnology history of the Netherlands.

Last, Dr. Kastelein received the first Lifetime Achievement Award of the Dutch Heart Foundation in 2010 as well as the ZonMW Parel price and has received the Anitschkov Price from the European Atherosclerosis Society for the best atherosclerosis research in Europe in June 2014. In 2014, Dr. Kastelein was also awarded the No.1 position among the Top Worldwide Expers in Hyperlipidemia Research and Treatment by Expertscape. He also was a recipient of the Huibregtsenprice 2014 for the best academic researcher in the Netherlands. He is listed on the worldwide list of the 400 most influential biomedical researchers, Eur J. Clin Invest 2013; 43: 1339-1365. Last, Thomson Reuters has ranked Dr. Kastelein among the top 1% of researchers for the most cited documents in his field and top 100 of the most influential clinical researchers globally in 2015.

 

Research programmes

Vascular Medicine

Since lowering systemic risk factors can only prevent 35% of cardiovascular events, novel interventions are needed. Two approaches are being pursued:
1. Directly increasing vessel-wall resistance against atherogenic insults.
2. Identifying inflammation-modulating pathways to attenuate atherogenesis

With respect to the first, efforts are being made to target the endothelial glycocalyx as therapeutic target.

With respect to the second, HDL-increasing agents are being evaluated as novel targets to attenuate pro-inflammatory changes.


Themes: Metabolic Disorders, Cardiovascular Diseases

Faculty
Prof. J.J.P. Kastelein MD PhD
Dr. ir. G.M. Dallinga-Thie PhD
Ir. J.C. Defesche PhD
Dr. G.K. Hovingh MD PhD (visiting professor at Imperial College London UK)
Dr. S.J. Pinto-Sietsma

PhD Students
I.K. Luirink
R.J. Roelants MD
Drs. J.C. van Capelleveen

Prof. dr. E.S.G. Stroes MD PhD (Novel anti-atherogenic strategies targeting the vessel wall)

Other research related activities
  • Membership of advisory board / Consultant, Sanofi-Aventis
  • Membership of advisory board / Consultant, The Medicines Company
  • Membership of advisory board / Consultant, F. Hoffmann-La Roche
  • Membership of advisory board / Consultant, CSL Behring
  • Membership of advisory board / Consultant, Eli Lilly
  • Stock / Shareholder, UniQure
  • Membership of advisory board / Consultant, Cerenis
  • Membership of advisory board / Consultant, Regeneron
  • Membership of advisory board / Consultant, Novartis BV
  • Membership of advisory board / Consultant, Pfizer BV
  • Membership of advisory board / Consultant, Staten Biotech Inc.
  • Membership of advisory board / Consultant, Teva Pharmaceuticals
  • Membership of advisory board / Consultant, Madrigal Pharmaceuticals Inc.
  • Membership of advisory board / Consultant, Corvidia
  • Membership of advisory board / Consultant, Gemphire Pharmaceuticals Inc.
  • Membership of advisory board / Consultant, Akarna Therapeutics
  • Membership of advisory board / Consultant, Affiris Therapeutics
  • Membership of advisory board / Consultant, Cymabay
  • Membership of advisory board / Consultant, Esperion Pharmaceuticals
  • Membership of advisory board / Consultant, Medpace Inc.
  • Membership of advisory board / Consultant, Alnylam Pharmaceuticals
  • Membership of advisory board / Consultant, Ionis Pharmaceuticals Inc.
  • Membership of advisory board / Consultant, LSP Advisory Inc.
  • Membership of advisory board / Consultant, Forbion Capital Partners
Current research funding
  • AMC