• Female

Dr. A.J. Tijsen

Position: Postdoc
Main activities: Research
Specialisation: Molecular Cardiology
foto
Focus of research:

- Allelic imbalance as explanation for differences in disease severity in inherited arrhythmias

- Inhibition of alleles with dominant-negative mutations as therapy in inherited arrhythmias and heart failure

I study these two aspects in iPS-derived cardiomyocytes

AMC themes: Cardiovascular Diseases
Departments: Cardiology
Smit NW, Cócera Ortega L, Végh AMD, Meijborg VMF, Smits AM, Klerk M, Tijsen AJM, Tan HL, Goumans MJHT, Boink GJJ, Coronel R, Human Cardiomyocyte Progenitor Cells in Co-culture with Rat Cardiomyocytes Form a Pro-arrhythmic Substrate: Evidence for Two Different Arrhythmogenic Mechanisms. FRONT PHYSIOL 2017;8:797 [PubMed]
van den Berg NWE , Kawasaki M, Berger WR, Neefs J, Meulendijks E, Tijsen AJ, de Groot JR, MicroRNAs in Atrial Fibrillation: from Expression Signatures to Functional Implications. CARDIOVASC DRUG THER 2017;31 (3):345-365 [PubMed]
Shinnawi R, Huber I, Maizels L, Shaheen N, Gepstein A, Arbel G, Tijsen AJ, Gepstein L, Monitoring Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Genetically Encoded Calcium and Voltage Fluorescent Reporters. STEM CELL REP 2015;5 (4):582-596 [PubMed]
Tijsen AJ, van der Made I, van den Hoogenhof MM, Wijnen WJ, van Deel ED, de Groot NE, Alekseev S, Fluiter K, Schroen B, Goumans MJ, van der Velden J, Duncker DJ, Pinto YM, Creemers EE, The microRNA-15 family inhibits the TGFβ-pathway in the heart. CARDIOVASC RES 2014;104 (1):61-71 [PubMed]
Wijnen WJ, van der Made I, van den Oever S, Hiller M, de Boer BA, Picavet DI, Chatzispyrou IA, Houtkooper RH, Tijsen AJ, Hagoort J, van Veen H, Everts V, Ruijter JM, Pinto YM, Creemers EE, Cardiomyocyte-specific miRNA-30c over-expression causes dilated cardiomyopathy. PLOS ONE 2014;9 (5):e96290 [PubMed]
Tijsen AJM. MicroRNAs in cardiac diseases. The devil is in the details. s.l.: s.n.; 2013. 291p. ISBN 9789461918581 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Pinto YM; copromotor(s): Creemers EEJM)
Amin AS, Giudicessi JR, Tijsen AJ, Spanjaart AM, Reckman YJ, Klemens CA, Tanck MW, Kapplinger JD, Hofman N, Sinner MF, Müller M, Wijnen WJ, Tan HL, Bezzina CR, Creemers EE, Wilde AAM, Ackerman MJ, Pinto YM, Variants in the 3 untranslated region of the KCNQ1-encoded K(v)7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner. EUR HEART J 2012;33 (6):714-723 [PubMed]
Creemers EE, Tijsen AJ, Pinto YM, Circulating MicroRNAs Novel Biomarkers and Extracellular Communicators in Cardiovascular Disease?. CIRC RES 2012;110 (3):483-495 [PubMed]
Tijsen AJ, Pinto YM, Creemers EE, Circulating microRNAs as diagnostic biomarkers for cardiovascular diseases. AM J PHYSIOL-HEART C 2012;303 (9):H1085-H1095 [PubMed]
Tijsen AJ, Pinto YM, Creemers EE, Non-cardiomyocyte microRNAs in heart failure. CARDIOVASC RES 2012;93 (4):573-582 [PubMed]
Sondermeijer BM, Bakker A, Halliani A, de Ronde MWJ, Marquart AA, Tijsen AJ, Mulders TA, Kok MGM, Battjes S, Maiwald S, Sivapalaratnam S, Trip MD, Moerland PD, Meijers JCM, Creemers EE, Pinto-Sietsma SJ, Platelets in patients with premature coronary artery disease exhibit upregulation of miRNA340* and miRNA624*. PLOS ONE 2011;6 (10):e25946 [PubMed]
Tijsen AJ, Creemers EE, Moerland PD, de Windt LJ, van der Wal AC, Kok WE, Pinto YM, MiR423-5p As a Circulating Biomarker for Heart Failure. CIRC RES 2010;106 (6):1035-U63 [PubMed]
Tijsen AJ, Creemers EE, Moerland PD, Pinto YM, MicroRNAs As Circulating Biomarkers for Heart Failure: Questions About MiR-423-5p Response. CIRC RES 2010;106 (9):E9
Duisters RF, Tijsen AJ, Schroen B, Leenders JJ, Lentink V, van der Made I, Herias V, van Leeuwen RE, Schellings MW, Barenbrug P, Maessen JG, Heymans S, Pinto YM, Creemers EE, miR-133 and miR-30 Regulate Connective Tissue Growth Factor Implications for a Role of MicroRNAs in Myocardial Matrix Remodeling. CIRC RES 2009;104 (2):170-U61 [PubMed]
Key publications

Tijsen AJ, Creemers EE, Moerland PD, de Windt LJ, van der Wal AC, Kok WE, Pinto YM, MiR423-5p As a Circulating Biomarker for Heart Failure. CIRC RES 2010;106 (6):1035-U63 [PubMed]
Tijsen AJ, van der Made I, van den Hoogenhof MM, Wijnen WJ, van Deel ED, de Groot NE, Alekseev S, Fluiter K, Schroen B, Goumans MJ, van der Velden J, Duncker DJ, Pinto YM, Creemers EE, The microRNA-15 family inhibits the TGFβ-pathway in the heart. CARDIOVASC RES 2014;104 (1):61-71 [PubMed]
Amin AS, Giudicessi JR, Tijsen AJ, Spanjaart AM, Reckman YJ, Klemens CA, Tanck MW, Kapplinger JD, Hofman N, Sinner MF, Müller M, Wijnen WJ, Tan HL, Bezzina CR, Creemers EE, Wilde AAM, Ackerman MJ, Pinto YM, Variants in the 3 untranslated region of the KCNQ1-encoded K(v)7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner. EUR HEART J 2012;33 (6):714-723 [PubMed]
Shinnawi R, Huber I, Maizels L, Shaheen N, Gepstein A, Arbel G, Tijsen AJ, Gepstein L, Monitoring Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Genetically Encoded Calcium and Voltage Fluorescent Reporters. STEM CELL REP 2015;5 (4):582-596 [PubMed]
Duisters RF, Tijsen AJ, Schroen B, Leenders JJ, Lentink V, van der Made I, Herias V, van Leeuwen RE, Schellings MW, Barenbrug P, Maessen JG, Heymans S, Pinto YM, Creemers EE, miR-133 and miR-30 Regulate Connective Tissue Growth Factor Implications for a Role of MicroRNAs in Myocardial Matrix Remodeling. CIRC RES 2009;104 (2):170-U61 [PubMed]


All Publications

Research programmes

Prof. dr. Y.M. Pinto (Molecular genetics of heart failure)

Other research related activities
  • None reported
Current research funding
  • AMC
  • Stichting AMC Foundation (Vrijgesteld)
  • ZonMw (Vrijgesteld)