• Male

Dr. M.F. Stevens MD PhD

Position: Associate professor (UHD)
Main activities: Patient care, Research
Specialisation: Anesthesiology
foto
Focus of research:

Pediatric Anesthesia, Acute pain management, Regional Anesthesia, Neurotoxicity of anesthetics and local anesthetics

 

AMC themes: Infection & Immunity, Other research
Departments: Anesthesiology
Hulst AH, Avis HJ, Hollmann MW, Stevens MF, In Response. A A CASE REP 2017;ahead of print [PubMed]
Hulst AH, Avis HJ, Hollmann MW, Stevens MF, Massive Subcutaneous Emphysema and Bilateral Tension Pneumothoraces After Supplemental Oxygen Delivery via an Airway Exchange Catheter: A Case Report. A A CASE REP 2017;8 (2):26-28 [PubMed]
Donders JCE, Baumann HM, Stevens MF, Kloen P, Hemorrhagic-Induced Cardiovascular Complications During Reamer-Irrigator-Aspirator-Assisted Femoral Nonunion Treatment. J ORTHOP TRAUMA 2016;30 (9):E294-E298 [PubMed]
Heijtel DFR, Petersen ET, Mutsaerts HJMM, Bakker E, Schober P, Stevens MF, van Berckel BNM, Majoie CBLM, Booij J, van Osch MJP, van Bavel ET, Boellaard R, Lammertsma AA, Nederveen AJ, Quantitative agreement between [(15)O]H2O PET and model free QUASAR MRI-derived cerebral blood flow and arterial blood volume. NMR BIOMED 2016;29 (4):519-526 [PubMed]
Kessler J, Wegener JT, Hollmann MW, Stevens MF, Teaching concepts in ultrasound-guided regional anesthesia. CURR OPIN ANESTHESIO 2016;29 (5):608-613 [PubMed]
Verlinde M, Hollmann MW, Stevens MF, Hermanns H, Werdehausen R, Lirk P, Local Anesthetic-Induced Neurotoxicity. INT J MOL SCI 2016;17 (3):339 [PubMed]
Wegener JT, Kraal T, Stevens MF, Hollmann MW, Kerkhoffs GMMJ, Haverkamp D, Low-dose dexamethasone during arthroplasty: What do we know about the risks?. EFORT OPEN REV 2016;1 (8):303-309 [PubMed]
Frkovic V, Ward C, Preckel B, Lirk P, Hollmann MW, Stevens MF, Wegener JT, Influence of arm position on ultrasound visibility of the axillary brachial plexus. EUR J ANAESTH 2015;32 (11):771-780 [PubMed]
Lirk P, Verhamme C, Boeckh R, Stevens MF, ten Hoope W, Gerner P, Blumenthal S, de Girolami U, van Schaik IN, Hollmann MW, Picardi S, Effects of early and late diabetic neuropathy on sciatic nerve block duration and neurotoxicity in Zucker diabetic fatty rats. BRIT J ANAESTH 2015;114 (2):319-326 [PubMed]
Stevens MF, van Lier F, Best of pediatric anesthesia 2014 of what is handoff. NED TIJDSCHR ANESTHESIOL 2015;28:16
Heijtel DFR, Mutsaerts HJMM, Bakker E, Schober P, Stevens MF, Petersen ET, van Berckel BNM, Majoie CBLM, Booij J, van Osch MJP, VanBavel E, Boellaard R, Lammertsma AA, Nederveen AJ, Accuracy and precision of pseudo-continuous arterial spin labeling perfusion during baseline and hypercapnia: a head-to-head comparison with ¹⁵O H₂O positron emission tomography. NEUROIMAGE 2014;92:182-192 [PubMed]
Lirk P. Local anesthetics: New insights into risks and benefits. S.l.: s.n.; 2014. 322p. ISBN 9789088919008 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Hollmann MW; copromotor(s): Hauck-Weber NC, Stevens MF)
Luiten WE, Schepers T, Luitse JS, Goslings JC, Hermanides J, Stevens MF, Hollmann MW, van Samkar G, Comparison of continuous nerve block versus patient-controlled analgesia for postoperative pain and outcome after talar and calcaneal fractures. FOOT ANKLE INT 2014;35 (11):1116-1121 [PubMed]
Picardi S, Stevens MF, Hahnenkamp K, Durieux ME, Lirk P, Hollmann MW, Time-dependent modulation of muscarinic m1/m3 receptor signalling by local anaesthetics. BRIT J ANAESTH 2014;112 (2):370-379 [PubMed]
Weenink RP, Hollmann MW, Stevens MF, Kager J, van Gulik TM, van Hulst RA, Detection of cerebral arterial gas embolism using regional cerebral oxygen saturation, quantitative electroencephalography, and brain oxygen tension in the swine. J NEUROSCI METH 2014;228:79-85 [PubMed]
Weenink RP, Hollmann MW, Vrijdag XCE, van Lienden KP, de Boo DW, Stevens MF, van Gulik TM, van Hulst RA, Obesity Paradox in Critically Ill Patients : authors' reply. CRIT CARE MED 2014;42 (3):e251-e252 [PubMed]
Lirk P, Rutten MVH, Haller I, Stevens MF, Laudolff-Birmingham J, Hollmann M, Birmingham B, Management of the patient with diabetic peripheral neuropathy presenting for peripheral regional anesthesia: a European survey and review of literature. MINERVA ANESTESIOL 2013;79 (9):1039-1048 [PubMed]
Picardi S, Cartellieri S, Groves D, Hahnenekamp K, Gerner P, Durieux ME, Stevens MF, Lirk P, Hollmann MW, Local anesthetic-induced inhibition of human neutrophil priming: the influence of structure, lipophilicity, and charge. REGION ANESTH PAIN M 2013;38 (1):9-15 [PubMed]
Weenink RP. Advances in diagnosis and treatment of cerebral arterial gas embolism. s.l.: s.n.; 2013. 227p. ISBN 9789090276885 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Hollmann MW, van Gulik TM; copromotor(s): van Hulst RA, Stevens MF)
Weenink RP, Hollmann MW, Vrijdag XCE, van Lienden KP, de Boo DW, Stevens MF, van Gulik TM, van Hulst RA, Hyperbaric oxygen does not improve cerebral function when started 2 or 4 hours after cerebral arterial gas embolism in swine. CRIT CARE MED 2013;41 (7):1719-1727 [PubMed]
Wegener JT. Educational and clinical aspects of peripheral nerve blockade. s.l.: s.n.; 2013. 159p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Hollmann MW, Preckel B; copromotor(s): Stevens MF)
Wegener JT, van Doorn CT, Eshuis JH, Hollmann MW, Preckel B, Stevens MF, Value of an electronic tutorial for image interpretation in ultrasound-guided regional anesthesia. REGION ANESTH PAIN M 2013;38 (1):44-49 [PubMed]
Wegener JT, van Ooij B , van Dijk CN, Karayeva SA, Hollmann MW, Preckel B, Stevens MF, Long-term pain and functional disability after total knee arthroplasty with and without single-injection or continuous sciatic nerve block in addition to continuous femoral nerve block: a prospective, 1-year follow-up of a randomized controlled trial. REGION ANESTH PAIN M 2013;38 (1):58-63 [PubMed]
Hermanides J, Hollmann MW, Stevens MF, Lirk P, Failed epidural: causes and management. BRIT J ANAESTH 2012;109 (2):144-154 [PubMed]
Koster HT, Avis HJ, Stevens MF, Hollmann MW, Metamizol bij postoperatieve pijnbestrijding. NED TIJDSCHR GENEESKD 2012;156 (14):A4323 [PubMed]
Lirk P, Flatz M, Haller I, Hausott B, Blumenthal S, Stevens MF, Suzuki S, Klimaschewski L, Gerner P, In Zucker Diabetic Fatty Rats, Subclinical Diabetic Neuropathy Increases In Vivo Lidocaine Block Duration But Not In Vitro Neurotoxicity. REGION ANESTH PAIN M 2012;37 (6):601-606 [PubMed]
Stevens MF. Mechanisms of neuro- and cytotoxicity of local anesthetics and their adjuvants. s.l.: s.n.; 2012. 169p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Hollmann MW; copromotor(s): Lirk PB)
Weenink RP, Vrijdag XCE, van Putten MJAM, Hollmann MW, Stevens MF, van Gulik TM, van Hulst RA, Quantitative electroencephalography in a swine model of cerebral arterial gas embolism. CLIN NEUROPHYSIOL 2012;123 (2):411-417 [PubMed]
Wegener J, Preckel B, Hollmann MW, Stevens MF, Sciatic Nerve Block for Analgesia After Total Knee Arthroplasty The Jury Is Still Out Reply. REGION ANESTH PAIN M 2012;37 (1):123-124 [PubMed]
Wegener JT, Preckel B, Hollmann MW, Stevens MF, Is a Single Sciatic Really Equivalent to a Continuous Sciatic Block for Total Knee Replacement? Reply. REGION ANESTH PAIN M 2012;37 (2):235 [PubMed]
Werdehausen R, Braun S, Fazeli S, Hermanns H, Hollmann MW, Bauer I, Stevens MF, Lipophilicity but not stereospecificity is a major determinant of local anaesthetic-induced cytotoxicity in human T-lymphoma cells. EUR J ANAESTH 2012;29 (1):35-41 [PubMed]
Stevens MF, de Nes L, Hollmann MW, Randomized clinical trial of epidural, spinal or patient-controlled analgesia for patients undergoing laparoscopic colorectal surgery (Br J Surg 2011; 98: 1068-1078). BRIT J SURG 2011;98 (12):1805-1805; author reply 1806 [PubMed]
Stevens MF, Werdehausen R, Gaza N, Hermanns H, Kremer D, Bauer I, Küry P, Hollmann MW, Braun S, Midazolam activates the intrinsic pathway of apoptosis independent of benzodiazepine and death receptor signaling. REGION ANESTH PAIN M 2011;36 (4):343-349 [PubMed]
Weenink RP, Hollmann MW, Stevens MF, van Lienden KP, Ghazi-Hosseini E, van Gulik TM, van Hulst RA, Cerebral arterial gas embolism in swine. Comparison of two sites for air injection. J NEUROSCI METH 2011;194 (2):336-341 [PubMed]
Wegener JT, Boender ZJ, Preckel B, Hollmann MW, Stevens MF, Comparison of percutaneous electrical nerve stimulation and ultrasound imaging for nerve localization. BRIT J ANAESTH 2011;106 (1):119-123 [PubMed]
Wegener JT, van Ooij B , van Dijk CN, Hollmann MW, Preckel B, Stevens MF, Value of single-injection or continuous sciatic nerve block in addition to a continuous femoral nerve block in patients undergoing total knee arthroplasty: a prospective, randomized, controlled trial. REGION ANESTH PAIN M 2011;36 (5):481-488 [PubMed]
Werdehausen R, Braun S, Hermanns H, Kremer D, Küry P, Hollmann MW, Bauer I, Stevens MF, The influence of adjuvants used in regional anesthesia on lidocaine-induced neurotoxicity in vitro. REGION ANESTH PAIN M 2011;36 (5):436-443 [PubMed]
Braun S, Gaza N, Werdehausen R, Hermanns H, Bauer I, Durieux ME, Hollmann MW, Stevens MF, Ketamine induces apoptosis via the mitochondrial pathway in human lymphocytes and neuronal cells. BRIT J ANAESTH 2010;105 (3):347-354 [PubMed]
Braun S, Werdehausen R, Gaza N, Hermanns H, Kremer D, Küry P, Hollmann MW, Stevens MF, Benzethonium increases the cytotoxicity of s(+)-ketamine in lymphoma, neuronal, and glial cells. ANESTH ANALG 2010;111 (6):1389-1393 [PubMed]
Gaza N. Mechanismen der Toxizität von Ketamin und Midazolam an Lymphom- und Neuroblastomzellen des Menschen. S.l.: s.n.; 2010. 61p. Proefschrift Heinrich-Heine-Universität, Düsseldorf, Medizinische Fakultät. (Promotor(s): Stevens MF; copromotor(s): Jäger M)
Braun S, Werdehausen R, Bothur T, Hermanns H, Lipfert P, Stevens MF, Incidental recognition of an aspirated tablet in an oesophagectomized patient. BRIT J ANAESTH 2009;103 (1):138-139 [PubMed]
Wegener JT, Frässdorf J, Stevens MF, Effective plexus anaesthesia in a patient with Ehlers-Danlos syndrome type III. EUR J ANAESTH 2009;26 (7):619-621 [PubMed]
Werdehausen R. Experimentelle Untersuchungen zur Bedeutung von Signalwegen der Apoptose für die Neurotoxizität von Lidocain. S.l.: s.n.; 2009. 71p. Proefschrift Heinrich-Heine-Universität, Düsseldorf, Medizinische Fakultät. (Promotor(s): Stevens MF; copromotor(s): Boege F)
Werdehausen R, Fazeli S, Braun S, Hermanns H, Essmann F, Hollmann MW, Bauer I, Stevens MF, Apoptosis induction by different local anaesthetics in a neuroblastoma cell line. BRIT J ANAESTH 2009;103 (5):711-718 [PubMed]
Koch T, Fichtner A, Schwemmer U, Standl T, Volk T, Engelhard K, Stevens MF, Putzke C, Scholz J, Zenz M, Motsch J, Hempel V, Heinrichs A, Zwissler B, Levobupivacaine for epidural anaesthesia and postoperative analgesia in hip surgery: a multi-center efficacy and safety equivalence study with bupivacaine and ropivacaine. ANAESTHESIST 2008;57 (5):475-482 [PubMed]
Stevens MF, Frequency-dependent block in humans?. ANESTH ANALG 2008;107 (3):1082-3; author reply 1083 [PubMed]
Hermanns H, Braun S, Werdehausen R, Werner A, Lipfert P, Stevens MF, Skin temperature after interscalene brachial plexus blockade. REGION ANESTH PAIN M 2007;32 (6):481-487 [PubMed]
Hermanns H, Lipfert P, Meier S, Jetzek-Zader M, Krauspe R, Stevens MF, Cortical somatosensory-evoked potentials during spine surgery in patients with neuromuscular and idiopathic scoliosis under propofol-remifentanil anaesthesia. BRIT J ANAESTH 2007;98 (3):362-365 [PubMed]
Jetzek-Zader M, Gudowius S, Feyen O, Stevens M, Lipfert P, Niehues T, A single intravenous dose of prednisolone induces phosphatidylserine externalization, loss of surface marker expression and a 24-h net increase in human peripheral blood lymphocytes ex vivo. RHEUMATOL INT 2007;27 (7):667-673 [PubMed]
Koch A, Zacharowski K, Boehm O, Stevens M, Lipfert P, von Giesen HJ, Wolf A, Freynhagen R, Nitric oxide and pro-inflammatory cytokines correlate with pain intensity in chronic pain patients. INFLAMM RES 2007;56 (1):32-37 [PubMed]
Stevens MF, Hermanns H, Freynhagen R, Novotny GEK, Lipfert P, Regeneration of baroafferents after implantation into different vessels. J PERIPHER NERV SYST 2007;12 (1):40-49 [PubMed]
Stevens MF, Schwarte LA, Golla E, Ilg A, Lipfert P, Hermanns H, Repeated pulmonary oedema after interscalene block and general anaesthesia. ACTA ANAESTH SCAND 2007;51 (5):645-647 [PubMed]
Stevens MF, Werdehausen R, Golla E, Braun S, Hermanns H, Ilg A, Willers R, Lipfert P, Does interscalene catheter placement with stimulating catheters improve postoperative pain or functional outcome after shoulder surgery? A prospective, randomized and double-blinded trial. ANESTH ANALG 2007;104 (2):442-447 [PubMed]
Werdehausen R, Braun S, Essmann F, Schulze-Osthoff K, Walczak H, Lipfert P, Stevens MF, Lidocaine induces apoptosis via the mitochondrial pathway independently of death receptor signaling. ANESTHESIOLOGY 2007;107 (1):136-143 [PubMed]
Werdehausen R, Braun S, Hermanns H, Freynhagen R, Lipfert P, Stevens MF, Uniform distribution of skin-temperature increase after different regional-anesthesia techniques of the lower extremity. REGION ANESTH PAIN M 2007;32 (1):73-78 [PubMed]
Werdehausen R, Braun S, Hermanns H, Krauspe R, Lipfert P, Stevens MF, Stimulating catheter as a tool to evaluate peripheral nerve function during hip rotationplasty. REGION ANESTH PAIN M 2007;32 (6):528-532 [PubMed]
Freynhagen R, Baron R, Tölle T, Stemmler E, Gockel U, Stevens M, Maier C, Screening of neuropathic pain components in patients with chronic back pain associated with nerve root compression: a prospective observational pilot study (MIPORT). CURR MED RES OPIN 2006;22 (3):529-537 [PubMed]
Freynhagen R, Muth-Selbach U, Lipfert P, Stevens MF, Zacharowski K, Tölle TR, von Giesen HJ, The effect of mirtazapine in patients with chronic pain and concomitant depression. CURR MED RES OPIN 2006;22 (2):257-264 [PubMed]
Hermanns H, Lipfert P, Ladda S, Stevens MF, Propofol infusion syndrome during anaesthesia for scoliosis surgery in an adolescent with neonatal progeroid syndrome. ACTA ANAESTH SCAND 2006;50 (3):392-394 [PubMed]
Hermanns H, Lipfert P, Stevens MF, Assessment of somatosensory evoked potentials during resuscitation of a 15-year-old boy with Duchenne muscular dystrophy. RESUSCITATION 2006;69 (3):521-524 [PubMed]
Hermanns H, Stevens MF, Werdehausen R, Braun S, Lipfert P, Jetzek-Zader M, Sedation during spinal anaesthesia in infants. BRIT J ANAESTH 2006;97 (3):380-384 [PubMed]
Jetzek-Zader M, Hermanns H, Freynhagen R, Lipfert P, Stevens MF, Increase in skin temperature after spinal anesthesia in infants. REGION ANESTH PAIN M 2006;31 (6):519-522 [PubMed]
Stevens MF, Golla E, Lipfert P, Intra- und postoperative Analgesie mit Kaudalkatheter bei einem Kind mit Schwartz-Jampel-Syndrom. ANAESTHESIST 2006;55 (5):555-560 [PubMed]
Stevens MF, Werdehausen R, Hermanns H, Lipfert P, Skin temperature during regional anesthesia of the lower extremity. ANESTH ANALG 2006;102 (4):1247-1251 [PubMed]
Stevens MF, Hoppe M, Holthusen H, Lipfert P, Tetrodotoxin-induced conduction blockade is prolonged by hyaluronic acid with and without bupivacaine. ACTA ANAESTH SCAND 2004;48 (1):128-134 [PubMed]
Stevens MF, Hoppe M, Holthusen H, Lipfert P, Tetrodotoxin-induced conduction blockade is prolonged by hyaluronic acid with and without bupivacaine [Corrected from: Acta Anaesthesiol Scand 48 (1), 2004, 128-134]. ACTA ANAESTH SCAND 2004;48 (3):128-134 [PubMed]
Stevens MF, Novotny GE, Lipfert P, Inactivation of baroafferents leads to loss of barosensitivity without changes in nerve morphology. J AUTONOM NERV SYST 1998;68 (3):125-134 [PubMed]
Stevens MF, Klement W, Lipfert P, Leitungsblockaden beim Menschen sind stimulationsfrequenzabhängig. ANAESTHESIST 1996;45 (6):533-537 [PubMed]
Stevens MF, Linstedt U, Neruda B, Lipfert P, Wulf H, Effect of transcutaneous electrical nerve stimulation on onset of axillary plexus block. ANAESTHESIA 1996;51 (10):916-919 [PubMed]
Holthusen H, Eichwede F, Stevens M, Willnow U, Lipfert P, Pre-emptive analgesia: comparison of preoperative with postoperative caudal block on postoperative pain in children. BRIT J ANAESTH 1994;73 (4):440-442 [PubMed]
Key publications

Wegener JT, van Ooij B , van Dijk CN, Hollmann MW, Preckel B, Stevens MF, Value of single-injection or continuous sciatic nerve block in addition to a continuous femoral nerve block in patients undergoing total knee arthroplasty: a prospective, randomized, controlled trial. REGION ANESTH PAIN M 2011;36 (5):481-488 [PubMed]
Braun S, Gaza N, Werdehausen R, Hermanns H, Bauer I, Durieux ME, Hollmann MW, Stevens MF, Ketamine induces apoptosis via the mitochondrial pathway in human lymphocytes and neuronal cells. BRIT J ANAESTH 2010;105 (3):347-354 [PubMed]
Werdehausen R, Fazeli S, Braun S, Hermanns H, Essmann F, Hollmann MW, Bauer I, Stevens MF, Apoptosis induction by different local anaesthetics in a neuroblastoma cell line. BRIT J ANAESTH 2009;103 (5):711-718 [PubMed]
Werdehausen R, Braun S, Essmann F, Schulze-Osthoff K, Walczak H, Lipfert P, Stevens MF, Lidocaine induces apoptosis via the mitochondrial pathway independently of death receptor signaling. ANESTHESIOLOGY 2007;107 (1):136-143 [PubMed]
Werdehausen R, Braun S, Hermanns H, Kremer D, Küry P, Hollmann MW, Bauer I, Stevens MF, The influence of adjuvants used in regional anesthesia on lidocaine-induced neurotoxicity in vitro. REGION ANESTH PAIN M 2011;36 (5):436-443 [PubMed]


All Publications

Curriculum Vitae

Curriculum vitae

Name: Priv.-Doz. Dr. Dr. Markus Florian Stevens, DEAA, DESRA

Education: M.D. Heinrich-Heine-University of Düsseldorf 1991

Doctoral thesis: Inactivation of baroafferents in rabbits leads to loss of barosensitivity without changes in nerve morphology 1993

Work Experience:

1991-93 Research Fellow, Department of Experimental Anesthesiology, University of Düsseldorf
1993-98 Training in Anesthesiology, University Hospital Düsseldorf
1998-2007 Consultant anesthesiologist at the Department of Anesthesiology; University Hospital Düsseldorf
2007 Consultant anesthesiologist at the Academic Medical Center, Amsterdam

Habilitation: New clinical and experimental aspects of regional anaesthesia, 2007
(postdoctoral qualification)

PhD thesis: Mechanisms of neuro- and cytotoxicity of local anesthetics and their adjuvants. 2012

Apprenticeships: Specialist in anesthesiology, Specialists in Medical Quality Management, Assessor of the European Foundation of Quality Management, Medical Informatics, Specialist in Emergency Medicine, Diplomat of the European Academy of Anaesthesiologists, Specialist in Intensive Care Medicine, Diplomat of the European Society of Regional Anaesthesia, Ultrasound in Regional Anesthesia

Research Subjects: Paediatric Anesthesia, Pathophysiology of peripheral nerves, Regional Anesthesia, Toxicity of local anaesthetics, Ultrasound in Anesthesia

Grants: 2x German Research Council (DFG Li 585/1-1) & (DFG Ste 983/1-1), AMC Moederproject.

Prizes: 2nd prize lecture competition of the German anaesthesia congress, Leipzig, 2006
3rd poster prize of the European Society of Regional Anaesthesia, Valencia, 2007
Beste proefschrift Abbvie award 2013 

Research programmes

Prof. M.J. Schultz MD PhD (Prevention and treatment of organ failure in intensive care medicine)

Dr. J. Horn MD PhD (Neurology on the Intensive Care Unit)

Prof. dr. B. Preckel MA MD PhD (Patient safety, procedural sedation, cardiovascular protection, optimizing perioperative metabolism, cerebral perfusion, Wireless Monitoring)

Prof. dr. M.W. Hollmann MD PhD (Organprotection)

Other research related activities
  • Speakers bureau / Lectures, University of Düsseldorf
  • lecturer, Academy for Perioperative Ultrasound
  • Membership of editorial board / Editorship, NEDERLANDS TIJDSCHRIFT VOOR ANESTHESIOLOGIE
  • Contribution to guidelines and protocols, CBO postoperatieve pijn
Current research funding
  • None reported