Tytgat Institute for Liver and Intestinal Research

The liver and intestinal research of the AMC is concentrated in the Tytgat Institute. Housing more than 70 basic and clinical scientists, we are one of the leading international research centers in gastroenterology and hepatology. Research in the Tytgat Institute is both fundamental and translational, but always built on a clinical question, providing results that can be translated into clinical practice. Extensive collaboration between physicians and researchers ensures a close link between the clinic and basic research.MC.

Cell and gene therapy

PI: Dr. J. Seppen, Dr. P.J. Bosma
We are exploring the use of viral and bacterial vectors in liver and intestinal disease. A clinical trial for Crigler Najjar syndrome using adeno-associated virus is in preparation. The AMC bioartificial liver, in which cell lines are used to replace liver function, will be tested in patients with acute liver failure in the near future.

Causes and treatment of cholestatic liver disease

PI: Prof.dr. R.P.J. Oude Elferink, Prof.dr. U. Beuers, Dr. C.C. Paulusma
The common theme of these studies is the characterization of transport processes involved in bile formation. This includes solute transport but particularly also lipid transport. Lipid translocation within biological membranes is not only studied in the context of bile formation but also in several other physiological processes. The molecular mechanism of cholestatic itch is studied and potential drugs to relieve it are tested.

Fat and drug metabolism

PI: Prof.dr. R.P.J. Oude Elferink
Fatty liver disease is an increasing problem in the western population as it is associated with obesity. In various mouse models the process of triglyceride accumulation in the liver is studied and conditions (drugs and nutrition) are tested for therapy of this syndrome.

Intestinal development and cancer

PI: Prof.dr. G.R. van den Brink
The fate of stem cells and their function is studied in transgenic mouse models. This allows a better understanding of cellular processes that underlie the disease mechanism of inflammatory bowel disease and colon cancer.

Gut inflammation and inflammatory bowel disease (IBD).

PI: Prof.dr. W. de Jonge, Prof.dr. H. Spits, Dr. A.A. te Velde
Several aspects of immune cells involved in IBD are studied, with the purpose to find targets for drug development. Further, we have a special interest in the brain-gut axis as a causal factor in functional bowel disorders such as irritable bowel syndrome and esophagitis. The role of mast cells is an important aspect of these studies.