A. van der Ende PhD

Associate Professor, Assistant Professor
Main activities
Biochemistry; Molecular Microbiology
Focus of research
  • Pathogenesis of meningococcal disease
  • Pathogenesis of invasive pneumococcal disease
  • Population structure of Neisseria meningitidis
  • Population structure of Streptococcus pneumoniae
  • Population structure of Chlamydiae
  • Molecular epidemiology and Genotyping of pathogenic bacteria
  • Bacterial Gene Expression Regulation
  • Antigenic Variation of bacterial Outer Membrane Proteins
Key publications
  • Bijlsma Merijn W., Bekker Vincent, Brouwer Matthijs C., Spanjaard Lodewijk, van de Beek Diederik, van der Ende Arie Epidemiology of invasive meningococcal disease in the Netherlands, 1960-2012: an analysis of national surveillance data Lancet infectious diseases 2014;14 (9):805-812 [PubMed]
  • Bekker Vincent, Bijlsma Merijn W., van de Beek Diederik, Kuijpers Taco W., van der Ende Arie Incidence of invasive group B streptococcal disease and pathogen genotype distribution in newborn babies in the Netherlands over 25 years: a nationwide surveillance study Lancet infectious diseases 2014;14 (11):1083-1089 [PubMed]
  • Bijlsma Merijn W., Brouwer Matthijs C., Spanjaard Lodewijk, van de Beek Diederik, van der Ende Arie A decade of herd protection after introduction of meningococcal serogroup C conjugate vaccination Clinical infectious diseases 2014;59 (9):1216-1221 [PubMed]
  • Knol Mirjam J., Wagenvoort Gertjan H. J., Sanders Elisabeth A. M., Elberse Karin, Vlaminckx Bart J., de Melker Hester E., van der Ende Arie Invasive Pneumococcal Disease 3 Years after Introduction of 10-Valent Pneumococcal Conjugate Vaccine, the Netherlands Emerging infectious diseases 2015;21 (11):2040-2044 [PubMed]
  • van Deursen Anna M. M., van Mens Suzan P., Sanders Elisabeth A. M., Vlaminckx Bart J. M., de Melker Hester E., Schouls Leo M., de Greeff Sabine C., van der Ende Arie Invasive pneumococcal disease and 7-valent pneumococcal conjugate vaccine, the Netherlands Emerging infectious diseases 2012;18 (11):1729-1737 [PubMed]
All Publications
Curriculum Vitae

Arie van der Ende received training in chemistry and biochemistry at the University of Groningen, the Netherlands. He did a PhD in molecular genetics at the Institute of Molecular Biology at the University of Utrecht (Utrecht, the Netherlands) and thereafter he joined the laboratory of Nobel Prize laureate Professor dr. Arthur Kornberg at Stanford University (Dept. of Biochemistry, Medical School, Stanford University, Palo Alto, California, USA). Hereafter, he was Assistant Professor in Cell Biology (Dept. of Cell Biology, Medical School, University of Utrecht, Utrecht, the Netherlands). At this moment he is Associate Professor in Medical Microbiology, head of the Laboratory for Experimental Bacteriology and head of the Netherlands Reference Laboratory for Bacterial Meningitis (all at the Dept. of Medical Microbiology, Academic Medical Centre, University of Amsterdam). His research interests are the pathogenesis and molecular epidemiology of bacterial meningitis. He has teaching responsibilities in BSc courses in Medicine and BSc/MSc courses in Life Sciences.

Research programmes

A. van der Ende PhD (Epidemiology and pathogenesis of bacterial meningitis)

The research on Bacterial Meningitis benefits strongly from the Netherlands Reference Laboratory for Bacterial Meningitis (NRLBM; head: Dr. A. van der Ende) located at the Department of Medical Microbiology, AMC. The NRLBM gives access to a collection of over 10,000 bacterial isolates form patients and carriers and of human clinical specimen (liquor and serum). In addition, basic patients’ data like age, gender, date of hospital admission and place of living are available but due to cooperative studies with dr. D. van de Beek (Department of Neurology, AMC) patients’ genetic material and data like clinical features and outcome are available of about 1500 patients.
We study the molecular epidemiology and population structure of the main pathogens causing meningitis, Neisseria meningitidis and Streptococcus pneumoniae, and of Chlamydia species causing respiratory infections and sexual transmitted disease. In addition, we study the pathogenesis of meningococcal and invasive pneumococcal disease. We are particularly interested in the bacterial stress response and its regulation by small RNAs (ribo-regulation) in conjunction with alternative sigma factors like sigmaE. In collaborative studies with Dr. D. van de Beek (Department of Neurology, AMC) we investigate clinical aspects of bacterial meningitis as well correlation between clinical features, outcome and host and bacterial factors.

Theme: Infection and Immunity

This research group participates in CINIMA

Y. Pannekoek PhD

A.W.M. Arends-van t Klooster
S. Bovenkerk BEng
W.C.M. Bril-Keijzers BEng
I.G.A. de Beer-Schuurman BEng
M.M. Feller
K. Schipper BEng

Current research funding
  • AMC
  • GlaxoSmithKline Biologicals SA
  • MSD International GmbH
  • Pfizer B.V. (4726)
  • RIVM