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C.A. Remme PhD

Position
Associate Professor
Main activities
Research
Specialisation
Basic and translational cardiac electrophysiology
Focus of research
 
• Translational studies into cardiac sodium channel (dys)function and inherited sodium channelopathies (including SCN5A mutations) associated with cardiac arrhythmias and sudden cardiac death, incorporating clinical and genetic with functional and mechanistic studies in transgenic models and human induced pluripotent stem cell-derived (iPSC) cardiomyocytes.

• Basic studies aimed at (1) unraveling mechanisms by which defective sodium channels mediate cardiac conduction slowing and arrhythmogenesis, (2) the complexity of sodium channel function and regulation, and (3) their diverse (non-electrogenic) roles in cardiac structure and function.

• Identification of novel (genetic) determinants, modifiers and pathways mediating cardiac electrophysiology and arrhythmia risk.

• Translational studies aimed at identifying novel targets for the prevention and treatment of cardiac arrhythmias and sudden cardiac death.

 

 

Key publications
  • Marsman Roos F. J., Bezzina Connie R., Freiberg Fabian, Verkerk Arie O., Adriaens Michiel E., Podliesna Svitlana, Chen Chen, Purfürst Bettina, Spallek Bastian, Koopmann Tamara T., Baczko Istvan, dos Remedios Cristobal G., George Alfred L., Bishopric Nanette H., Lodder Elisabeth M., de Bakker Jacques M. T., Fischer Robert, Coronel Ruben, Wilde Arthur A. M., Gotthardt Michael, Remme Carol Ann Coxsackie and Adenovirus Receptor Is a Modifier of Cardiac Conduction and Arrhythmia Vulnerability in the Setting of Myocardial Ischemia Journal of the American College of Cardiology 2014;63 (6):549-559 [PubMed]
  • Bezzina Connie R., Barc Julien, Mizusawa Yuka, Remme Carol Ann, Gourraud Jean-Baptiste, Simonet Floriane, Verkerk Arie O., Schwartz Peter J., Crotti Lia, Dagradi Federica, Guicheney Pascale, Fressart Véronique, Leenhardt Antoine, Antzelevitch Charles, Bartkowiak Susan, Borggrefe Martin, Schimpf Rainer, Schulze-Bahr Eric, Zumhagen Sven, Behr Elijah R., Bastiaenen Rachel, Tfelt-Hansen Jacob, Olesen Morten Salling, Kääb Stefan, Beckmann Britt M., Weeke Peter, Watanabe Hiroshi, Endo Naoto, Minamino Tohru, Horie Minoru, Ohno Seiko, Hasegawa Kanae, Makita Naomasa, Nogami Akihiko, Shimizu Wataru, Aiba Takeshi, Froguel Philippe, Balkau Beverley, Lantieri Olivier, Torchio Margherita, Wiese Cornelia, Weber David, Wolswinkel Rianne, Coronel Ruben, Boukens Bas J., Bézieau Stéphane, Charpentier Eric, Chatel Stéphanie, Despres Aurore, Gros Françoise, Kyndt Florence, Lecointe Simon, Lindenbaum Pierre, Portero Vincent, Violleau Jade, Gessler Manfred, Tan Hanno L., Roden Dan M., Christoffels Vincent M., Le Marec Hervé, Wilde Arthur A., Probst Vincent, Schott Jean-Jacques, Dina Christian, Redon Richard Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death Nature genetics 2013;45 (9):1044-1049 [PubMed]
  • Portero Vincent, Casini Simona, Hoekstra Maaike, Verkerk Arie O., Mengarelli Isabella, Belardinelli Luiz, Rajamani Sridharan, Wilde Arthur A. M., Bezzina Connie R., Veldkamp Marieke W., Remme Carol Ann Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes Cardiovascular research 2017;113 (7):829-838 [PubMed]
  • Rivaud Mathilde R., Agullo-Pascual Esperanza, Lin Xianming, Leo-Macias Alejandra, Zhang Mingliang, Rothenberg Eli, Bezzina Connie R., Delmar Mario, Remme Carol Ann Sodium Channel Remodeling in Subcellular Microdomains of Murine Failing Cardiomyocytes Journal of the American Heart Association 2017;6 (12):e007622 [PubMed]
All Publications
Research programmes

C.A. Remme PhD (Basic and translational cardiac electrophysiology)

Basic and translational studies into cardiac arrhythmias and sudden cardiac death

Postdocs
S. Casini PhD
V.M. Portero PhD

PhD Students
S.M. van der Voorn MSc

Others
G.A. Marchal
R. Wolswinkel BSc

Current research funding
  • AMC
  • Netherlands Heart Institute
  • Stichting AMC Foundation (Vrijgesteld)
  • ZonMw