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Dr. B. Blom

Position
Associate professor (UHD)
Main activities
Teaching, Research
Specialisation
Immunology
Focus of research

Development and function of human lymphocytes with a particular focuss on the development and function of T cells, B cells and innate lymphoid cells (ILCs) in patients that undergo allogeneic stem cell transplantations.

Key publications
  • Nagasawa M, Germar K, Blom B, Spits H, Human CD5(+) Innate Lymphoid Cells Are Functionally Immature and Their Development from CD34(+) Progenitor Cells Is Regulated by Id2. FRONT IMMUNOL 2017;8:1047 [PubMed]
  • Karrich JJ, Jachimowski LCM, Libouban M, Iyer A, Brandwijk K, Taanman-Kueter EW, Nagasawa M, de Jong EC, Uittenbogaart CH, Blom B, MicroRNA-146a regulates survival and maturation of human plasmacytoid dendritic cells. BLOOD 2013;122 (17):3001-3009 [PubMed]
  • Karrich JJ, Jachimowski LCM, Nagasawa M, Kamp A, Balzarolo M, Wolkers MC, Uittenbogaart CH, van Ham SM, Blom B, IL-21-stimulated human plasmacytoid dendritic cells secrete granzyme B, which impairs their capacity to induce T-cell proliferation. BLOOD 2013;121 (16):3103-3111 [PubMed]
  • Karrich JJ, Balzarolo M, Schmidlin H, Libouban M, Nagasawa M, Gentek R, Kamihira S, Maeda T, Amsen D, Wolkers MC, Blom B, The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1. BLOOD 2012;119 (22):5191-5200 [PubMed]
  • Karrich JJ, Jachimowski LCM, Uittenbogaart CH, Blom B, The plasmacytoid dendritic cell as the Swiss army knife of the immune system: molecular regulation of its multifaceted functions. J IMMUNOL 2014;193 (12):5772-5778 [PubMed]
All Publications
Curriculum Vitae

 Positions and Employment:

1993-1997:     PhD student, Netherlands Cancer Institute, Amsterdam

1997-2000:     Postdoctoral fellow, Schering at DNAX (owned by Schering Plough, now Merck), Palo Alto, CA USA

2000-2003:     Senior Postdoc, Netherlands Cancer Institute, Amsterdam

2003-2006:     Assistant Professor, Amsterdam Medical Center/University of Amsterdam, Amsterdam

2006-present: Associate Professor, Amsterdam Medical Center/University of Amsterdam, Amsterdam

2010-present: Principal Investigator, Amsterdam Medical Center/University of Amsterdam, Amsterdam

2015-present: Principal Educator, Amsterdam Medical Center/University of Amsterdam, Amsterdam

2016-present: Head of the HIS mouse facility, Amsterdam Medical Center/University of Amsterdam, Amsterdam

Research programmes

Development and function of human lymphocytes

Our immune system develops from hematopoietic stem cells, which through sequential steps commit into mature effector cells. These processes are tightly orchestrated by cytokines and transcription factors that enforce lineage decisions. Our main objective focusses on the development and function of the lymphoid compartment, including T, B, Natural Killer (NK), innate lymphoid cells (ILCs)and plasmacytoid dendritic cells (pDC) (Blom & Spits, Annu Rev Immunol. 2006). The cytokines that we consider of interest in this context include IL-7, TSLP, FLT3L, IL-15, and IL-21. The families of transcription factors that we, in close collaboration with Prof. dr. Hergen Spits, study include members of the (basic)-helix-loop-helix, Notch, GATA, and Ets families (Nagasawa et al. Front Immunol. 2017, Shikhagaie et al. Cell Rep. 2017, Karrich et al. J Immunol. 2014, Karrich et al. Blood 2013a, Karrich et al. Blood 2013b, Karrich et al. Blood 2012, Dontje et al. Blood 2006, Schmidlin et al. Blood 2006, Colantonio et al. Plos One 2011, Schotte et al. J Exp Med 2004).

Patients that suffer from hematological malignancies may be cured by an allogeneic hematopoietic stem cell transplantation resulting from the graft versus leukemia/lymphoma (GvL) effect. This therapeutic intervention, however, is frequently complicated by graft-versus-host-disease (GvHD) and opportunistic infections causing high morbidity and mortality. As ILCs, in particular the subgroup ILC3, have been forwarded as guardians of the mucosal barriers by the production of IL-22 that restores epithelial linings, we in close collaboration with dr. Mette Hazenberg aim to investigate the role of ILCs in patients that suffer from GvHD.

Theme: Infection and Immunity

Faculty
Dr. B. Blom

PhD Students
K. Liu MD
S.Z. Omar

Others
Drs. K.I.M. Brandwijk

Dr. M.D. Hazenberg MD PhD (Innate and adaptive immunity following allogeneic hematopoietic stem cell transplantation)

Other research related activities
  • Contribution to training of professionals, University of Amsterdam
  • Contribution to training of professionals, VU University Medical Center
  • Membership of medical or scientific committee, University of Amsterdam, head HIS mouse facility
  • Membership of medical or scientific committee, University of Amsterdam, member user cie Flowcytometry
  • Membership of medical or scientific committee, University of Amsterdam, Amsterdam Infection&Immunity Institute, program leader Inflammatory Diseases