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Dr. C. Ris-Stalpers PhD

Position
Associate professor (UHD)
Main activities
Research
Specialisation
Molecular Obstetrics & Molecular Endocrinology
Focus of research

About 25% of all pregnancies are complicated by gestational disease, of which severe hypertension (i.e. early preeclampsia and HELLP syndrome) and preterm labour are the leading cause of pregnancy-related maternal morbidity and mortality and poor neonatal outcome. Although there is consensus that the causal organ for these gestational diseases is the placenta the underlying multifactorial molecular causes and early and reliable clinical biomarkers that explain and predict development of obstetrical disease during the course of pregnancy are not available.

The past years, the department of Obstetrics and Gynaecology of the AMC has (with METC approval) set up an infrastructure called the Preeclampsia And Non-preeclampsia DAtabase (PANDA), in which we collect placental biopsies and maternal and fetal genomic DNA and blood of over 400 pregnancies. This infrastructure has enabled us to carry out several important research projects. We collaborated in a study validating a novel marker for preeclampsia, we have identified a placental signature specific for HELLP syndrome, we have discovered four novel highly placenta specific genes relevant for the development of early and severe preeclampsia and investigated the relation of placental specific spliced variants of the FLT1 gene to gestational hypertensive disease and fetal growth.
 

The PANDA biobanking effort will during 2010 be extended by the collection of myometrium and placental bed biopsies, essential to our further studies on the molecular basis of premature labour and early placentation.

Key publications
  • Iglesias-Platas I, Monk D, Jebbink J, Buimer M, Boer K, van der Post J, Hills F, Apostolidou S, Ris-Stalpers C, Stanier P, Moore GE, STOX1 is not imprinted and is not likely to be involved in preeclampsia. NAT GENET 2007;39 (3):279-80; author reply 280-1 [PubMed]
  • Jebbink J, Wolters A, Fernando F, Afink G, van der Post J, Ris-Stalpers C, Molecular genetics of preeclampsia and HELLP syndrome - A review. BBA-MOL BASIS DIS 2012;1822 (12):1960-1969 [PubMed]
  • Jebbink J, Keijser R, Veenboer G, van der Post J, Ris-Stalpers C, Afink G, Expression of Placental FLT1 Transcript Variants Relates to Both Gestational Hypertensive Disease and Fetal Growth. HYPERTENSION 2011;58 (1):70-U129 [PubMed]
  • Kleinrouweler CE, van Uitert M, Moerland PD, Ris-Stalpers C, van der Post JAM, Afink GB, Differentially expressed genes in the pre-eclamptic placenta: a systematic review and meta-analysis. PLOS ONE 2013;8 (7):e68991 [PubMed]
  • Ris-Stalpers C, Physiology and pathophysiology of the DUOXes. ANTIOXID REDOX SIGN 2006;8 (9-10):1563-1572 [PubMed]
All Publications
Curriculum Vitae

Personal details
Name: Carrie Ris-Stalpers PhD
Title: Associate professor
Date of birth: March 18th, 1962
Nationality: Dutch
Marital status: married, 2 children

Education
Master’s: Msc Chemistry, Faculty of Mathematics and Physics, University of Amsterdam (1987)
Main subjects: Microbiology, Experimental Endocrinology.
Doctorate: Erasmus University Rotterdam (June 29th, 1994), Supervisor Prof Dr JA Grootegoed
Thesis title: Mutations in the human androgen receptor and the androgen receptor insensitivity syndrome

Affiliations
1987 – 1992
Onderzoeker in Opleiding’ with NWO at the department of Endocrinology & ReproductionDepartment of Medicine, Erasmus University Rotterdam.
1993 – 1996
Postdoctoral research fellow on the laboratory of pediatric endocrinology of the Emma Childrens Hospital, AMC, Amsterdam.
Project funded by the EG: biocommunication in thyroid autoimmune diseases: from molecular biology to clinical investigation.
1996 – 2008
Supervisor of the laboratory of Pediatric Endocrinology of the AMC
2003 – 2004
Staff member of the department of Pediatrics, ODP leider Pediatric Endocrinology GEMO 07 ad interim
member of the Wetenschappelijke Adviesraad GEMO
2005 – 2008
ODP leider Pediatric Endocrinology GEMO 07, member of the Wetenschappelijke Adviesraad GEMO
2006
Appointed Universitair Hoofddocent
2008
Staff member of the department of Gynaecology & Obstetrics
2009
Establishment of the Molecular Obstetrics research group as part of the Laboratory of Reproductive Biology
 

Supervised PhD students
Completed
2000 Simone AR van de Graaf; New insights in the human thyroglobulin structure
2003 José C Moreno; Novel thyroid specific transcripts identified by SAGE: implications for congenital hypothyroidism
2003 Erwin Pauws; Gene Expression in thyroid and thyroid cancer
2008 Maarten Buimer; The placenta as modulator of fetal prosperity
Ongoing
2011 Jiska de Haan-Jebbink


 

Research programmes

Prof. dr. J.A.M. van der Post MD PhD (Reproductive Health, placental disease and maternal and fetal diseases)

Prof. dr. S. Repping (Reproduction & Development -- Human Reproduction)

Current research funding
  • AMC
  • Stichting AMC Foundation (Vrijgesteld)