foto

Dr. D.H. Nieman

Position
Associate professor (UHD)
Main activities
Research, Patient care, Teaching
Specialisation
Psychiatry, clinical psychology
Focus of research

Neurophysiology, neuropsychology and treatment of recent onset schizophrenia and its prodrome

Key publications
  • Nieman DH, Ruhrmann S, Dragt S, Soen F, van Tricht MJ, Koelman JHTM, Bour LJ, Velthorst E, Becker HE, Weiser M, Linszen DH, de Haan L, Psychosis prediction: stratification of risk estimation with information-processing and premorbid functioning variables. SCHIZOPHRENIA BULL 2014;40 (6):1482-1490 [PubMed]
  • van Tricht MJ, Ruhrmann S, Arns M, Müller R, Bodatsch M, Velthorst E, Koelman JHTM, Bour LJ, Zurek K, Schultze-Lutter F, Klosterkötter J, Linszen DH, de Haan L, Brockhaus-Dumke A, Nieman DH, Can quantitative EEG measures predict clinical outcome in subjects at Clinical High Risk for psychosis? A prospective multicenter study. SCHIZOPHR RES 2014;153 (1-3):42-47 [PubMed]
  • Nieman DH, Velthorst E, Becker HE, de Haan L, Dingemans PM, Linszen DH, Birchwood M, Patterson P, Salokangas RKR, Heinimaa M, Heinz A, Juckel G, von Reventlow HG, Morrison A, Schultze-Lutter F, Klosterkötter J, Ruhrmann S [Contributors: McGorry PD, McGlashan TH, Knapp M, van de Fliert R, Klaassen R, Picker H, Neumann M, Brockhaus-Dumke A, Pukrop R, Svirskis T, Huttunen J, Laine T, Ilonen T, Ristkari T, Hietala J, Skeate A, Gudlowski Y, Ozgürdal S, French P, Stevens H]] , The Strauss and Carpenter Prognostic Scale in subjects clinically at high risk of psychosis. ACTA PSYCHIAT SCAND 2013;127 (1):53-61 [PubMed]
  • Nieman DH, Dragt S, van Duin EDA, Denneman N, Overbeek JM, de Haan L, Rietdijk J, Ising HK, Klaassen RMC, van Amelsvoort T, Wunderink L, van der Gaag M, Linszen DH, COMT Val(158)Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions. SCHIZOPHR RES 2016;174 (1-3):24-28 [PubMed]
  • Fusar-Poli P, Cappucciati M, Borgwardt S, Woods SW, Addington J, Nelson B, Nieman DH, Stahl DR, Rutigliano G, Riecher-Rössler A, Simon AE, Mizuno M, Lee TY, Kwon JS, Lam MML, Perez J, Keri S, Amminger P, Metzler S, Kawohl W, Rössler W, Lee J, Labad J, Ziermans T, An SK, Liu CC, Woodberry KA, Braham A, Corcoran C, McGorry P, Yung AR, McGuire PK, Heterogeneity of Psychosis Risk Within Individuals at Clinical High Risk: A Meta-analytical Stratification. JAMA PSYCHIAT 2016;73 (2):113-120 [PubMed]
All Publications
Curriculum Vitae

Dorien H. Nieman, PhD
Academic Medical Center
Dept. of Psychiatry
University of Amsterdam
PO Box 75867
1070 AW Amsterdam
The Netherlands

Tel. +31-20-8913683
Fax: +31-20-8913536
Email: d.h.nieman@amc.nl

Personal details
Female, married, 2 children (Tristan and Florian)
Born Novermber 9, 1968, Purmerend, The Netherlands

Master’s
University of Amsterdam, Department of Psychology
August 1994 MSc

PhD
1996-2001 Ph.D. University of Amsterdam
Supervisors: Prof. Dr. D.H. Linszen, Prof. Dr. B.W. Ongerboer de Visser
Title thesis: Neurophysiological and neuropsychological correlates of symptom dimensions of recent onset schizophrenia.

Postdoctoral clinical training
2001-2003 Health care psychology
2006-2010 Clinical psychology Registration number BIG: 39060895525

Work experience since graduating
1996-2001 PhD student Department of Psychiatry and Department of Neurology/Clinical Neurophysiology Unit, Academic Medical Center, Amsterdam (fixed term, full time)
2001-2006 Post doc and psychologist Department of Psychiatry, Academic Medical Center, Amsterdam (fixed term, full time)
2006- Post doc, clinical psychologist and cognitive behavioural therapist (registration number: 203157), Department of Psychiatry, Academic Medical Center, Amsterdam (tenured, part time) 2012- Coordinator of the Ultra High Risk outpatient clinic of the Department of Psychiatry, Academic Medical Center, The Netherlands 2014- Principal Investigator and Head of the Cognition lab of the Department of Psychiatry, Academic Medical Center, The Netherlands  

Brief summary of research over last five years
In the past 5 years D. Nieman has focused on neurophysiological, neuropsychological and clinical research in subjects with an ultra high risk (UHR) for developing a first psychosis. In the ZonMw funded Dutch Prediction of Psychosis Study and the European Commission funded European Prediction of Psychosis Study, subjects with an ultra high risk for developing psychosis were detected and followed for three years. Several predictors of a first psychotic episode were found. In addition, underlying biological mechanisms and symptomatology of the prodromal period and transition to psychosis were studied longitudinally. D. Nieman was post doc in these projects. In the ZonMw funded project ‘Prevention of psychosis with a cognitive behavioural intervention in help-seeking young people with an at risk mental state for developing psychosis’ a newly developed treatment for UHR subjects was investigated in a multicenter randomized clinical trial. This study aimed at reducing the number of transitions to a first psychotic episode in help-seeking UHR subjects with cognitive behavioural therapy. D. Nieman was coordinator of the AMC site in this project. A major theme in a recently started project is investigating the relationship between genotype, endophenotype and phenotype in psychiatric disorders and their prodrome.

 H-index (Google scholar): 17

 International activities

Reviewer international:
Schizophrenia Research, Archives of General Psychiatry, Schizophrenia Bulletin, Bipolar Disorders, Psychiatry Research, Psychopharmacology, Clinical Neuropharmacology, Biological Psychiatry

 (Inter)national lectures/invitations:

  • Preventive psychotherapy. National Mental Health Conference. Antwerp, Belgium. September 17, 2014.
  • Chair symposium ‘At Risk Mental State Treatment Update’. Speakers: P. McGorry, A. Morrison, M. van der Gaag, D. Nieman. Schizophrenia Symposium: At Risk Mental State Treatment Update. Schizophrenia International Research Society conference, Florence, Italy 2014. Chair and speaker. Other speakers: P. McGorry, A. Morrison, M. van der Gaag, S. Ruhrmann.
  • Neurophysiological paradigms in subjects at ultra high risk for psychosis. International congress on schizophrenia research, Colorado Springs, 2012
  • Cognitive behavioural therapy can change the appraisal of voices. International congress on schizophrenia research, Florence, April 16, 2010.
  • P300 event related potential in subjects at ultra high risk for developing psychosis. 5th International Conference on Early Psychosis, Birmingham, October 5, 2006.
  • Eye movement abnormalities in patients at risk for developing psychosis.12th Congress of the Association of European Psychiatrists, April 15, 2004.
  • Neurophysiological research findings in the prodromal period of psychosis. Turku, February 26, 2004.
  • The anti-saccade test in young patients with schizophrenia. Dutch working group for neuro-ophtalmology. April 24, 1998. 
  • Neurophysiological and neuropsychological research in young patients with schizophrenia. Regional working group neuropsychology, September 21, 1998.
  • Neurophysiological and neuropsychological correlates of symptom dimensions of recent-onset schizophrenia. Master Class of prof. dr Nancy Andreasen (USA), organised by the Board of Directors of the AMC, October 31, 1997.  

Organisation conference

  • The earlier, the better?! The Hague, Netherlands. May 30, 2013. Co- organisors M. van der Gaag, F. van de Kar. Keynote speakers: J. van Os (chair), A. Yung, M. van der Gaag, D. Nieman

Invited sabbatical

  • Prof. dr. P. McGorry, University of Melbourne, Australia. October-December 2014 

International collaborations

  •  Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany: prof. dr. S. Ruhrmann.
  • Institute of Psychiatry, University of London, UK: dr. P. Fusar-Poli, Prof. dr. P. McGuire
  • School of Psychology, University of Birmingham, Birmingham, UK: prof. dr. M. Birchwood, dr. P. Patterson
  • Dept. of Psychiatry, University of Turku, Turku, Finland: prof. dr. R. Salokangas, dr. M. Heinimaa.
  • Dept. of Psychiatry, Psychotherapy and Psychosomatic Medicine, Ruhr-University Bochum, Bochum, Germany: prof. dr. G. Juckel, dr. H. Graf von Reventlow.
  • Dept. of Psychiatry, Greater Manchester West Mental Health Trust, Manchester, School of Psychological Sciences, University of Manchester, Manchester, UK.: dr. P. French
  • Department of Psychiatry, University of Melbourne, Australia: Prof. dr. P. McGorry, dr. B. Nelson

Other academic activities

Involved in the following current PhD projects

  • Anna Domen (AMC): Transdiagnostic cognitive dysfunctions in psychiatric patients. Expected year of thesis defence: 2017
  • Hiske Becker (AMC). Neuropsychological markers of transition to a first psychotic episode. Expected year of thesis defence: 2014
  • Mariska Mantione (AMC): Neuropsychology of deep brain stimulation in patients with obsessive compulsive disorder. Expected year of thesis defence: 2014
  • Bouke Sterk (AMC). Implementation of an early detection of psychosis project in Amsterdam. Expected year of thesis defence: 2015

Completed PhD projects

  • Dragt S. Exploring the road to a first psychosis. Work in progress 2011. 176p. ISBN 9789090263076. PhD thesis University of Amsterdam. Promotor(s): Linszen DH, van der Gaag M; copromotor: Nieman DH
  •  Velthorst E. The lonely soul wanders. On the role of impaired social functioning in the prediction of first psychosis 2011. 191p. ISBN 9789090263083 PhD thesis University of Amsterdam. (Promotor(s): Linszen DH, de Haan L; copromotor: Nieman DH
  • van Tricht M. Neurophysiological correlates of the pathway to the early stages of psychosis 2013. 218p ISBN 978-94-6182-271-0. PhD thesis University of Amsterdam. (Promotor(s): Linszen DH, de Haan L; copromotors: Nieman DH, Koelman JH.
  • Klaassen RMC. Emerging symptoms on the pathway to psychosis; 2013. 179p. ISBN 9789088917110 PhD thesis Universiteit van Amsterdam. Promotor(s): de Haan L, van der Gaag M; copromotor(s): Nieman DH, van Beveren N

Local collaborations

Department of Neurology/Clinical Neurophysiology Unit, AMC: J. Koelman, L. Bour

 National collaborations

  • VU University/Parnassia: M. van der Gaag
  • UMCU: S. Durston, P. Schothorst
  • Rivierduinen: R. Klaassen
  • GGZ Friesland: L. Wunderink

Professional memberships

  • International Early Psychosis Association
  • Schizophrenia International Research Society
  • Dutch Association for Cognitive and Behavioural Therapy

Editorial experience

  • Editorial board member of the World Journal of Psychiatr
  • Editorial board member of the Austin Journal of Clinical Case Reports

Awards and grants

Young Scientist Award, 10th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 2000

"Early detection of psychosis: the efficacy of an early detection program in Amsterdam’ Nieman DH (author), Linszen DH, Van Amelsvoort TA, Becker HE, Birchwood M, Dingemans PM, De Haan L (Principal Investigator), Lester H, Van der Fliert R, € 468.719 ZonMw 2007. 

Cognitive remediation in psychiatric patients with an applied online cognitive game and assessment tool. Nieman DH, Kumar R, Sparrowhawk K, Knight D, Sala M, Jaspers M, Schene A, de Haan L, Denys D. € 425.048 Life Science and Health-Match/Netherlands Genomics Initiative 2013

Cognitive Behavioural Therapy focussing on Social Activation in Patients with Recent Onset Schizophrenia. Meijer CJ, Velthorst E, Nieman DH, van der Gaag M, Grant P, Koeter M, Smit F, Staring T, de Haan L, € 149.774. ZonMw 2014

Publications

International refereed publications, in press

  • Nieman DH, Ruhrmann S, Dragt S, Soen F, van Tricht MJ, Koelman JH, Bour LJ, Velthorst E, Becker HE, Weiser M, Linszen DH, de Haan L. Psychosis Prediction: Stratification of Risk Estimation With Information-Processing and Premorbid Functioning Variables. Schizophrenia Bulletin (IF 8.486).
  • Van Tricht MJ, Ruhrmann S, Arns M, Müller R, Bodatsch M, Velthorst E, Koelman JH, Bour LJ, Zurek K, Schultze-Lutter F, Klosterkötter J, Linszen DH, de Haan L, Nieman DH. Can quantative EEG measures predict clinical outcome in subjects at ultra high risk for psychosis? A prospective mulicentre study. Schizophrenia Res (IF 4.59)
  • Rietdijk J, ising HK, Dragt S, Klaassen R, Nieman D, Wunderink L, Cuijpers P, Linszen D, van der Gaag M. Depression and social anxiety in help-seeking patients with an ultra-high risk for developing psychosis. Soc Psychiatry Psychiatr Epidemiol (IF 2.861)
  • Mantione M, Nieman DH, Figee M, Denys D. Cognitive behavioural therapy augments the effects of deep brain stimulation in obsessive compulsive disorder. Psychological Medicine (IF 5.587)
  • Velthorst E, Koeter M, van der Gaag M, Nieman DH, Fett AJ, Smit F, Staring ABP, Meijer C, de Haan L. Adapted CBT required for targeting negative symptoms in schizophrenia: meta-analysis and meta-regression. Psychological Medicine (IF 5.587)

Submitted after revision

  • Van Tricht, Bour LJ, Koelman JH, Braff DL, de Wilde O, Boerée T, Linszen DH, de Haan L, Nieman DH. State and trait aspects of information processing deficits associated with transition: a longitudinal study from prodromal state to first psychosis
  • Ising HK, Veling W, Rietdijk J, Dragt S, Klaassen R, Savelsberg N, Boonstra N, Nieman D, Wunderink L, Linszen D, Smit F, and van der Gaag M. Cost-utility and cost-effectiveness of the prevention of a first episode psychosis in ultra high risk subjects.
  • Ising H, Ruhrmann S, Veling W, Rietdijk J, Dragt S, Klaasen M, Burger N, Nieman DH, Boonstra N, Wundering L, Linszen DH, van der Gaag M. Predictors of onset among young treatment seeking patients with an ultra high risk status in the EDIE-NL study

International refereed publications

  • Van Tricht MJ, Harmsen E, Koelman JH, Bour L, van Amelsvoort TA, Linszen DH, de Haan L, Nieman DH. Effects of cannabis use on Event Related Potentials in subjects at ultra high risk for psychosis and healthy controls. International Journal of Psychophysiology. 2013;88(2):149-56. (IF 2.036)
  • Velthorst E, Derks EM, Schothorst P, Becker H, Durston S, Ziermans T, Nieman DH, de Haan L. Quantitative and qualitative symptomatic differences in individuals at Ultra-High Risk for psychosis and healthy controls. Psychiatry Res. 2013;210(2):432-7. (IF 2.456)
  • van der Gaag M, Nieman DH, Rietdijk J, Dragt S, Ising HK, Klaassen RM, Koeter M, Cuijpers P, Wunderink L, Linszen DH.Cognitive Behavioral Therapy for Subjects at Ultra high Risk for Developing Psychosis: A Randomized Controlled Clinical Trial. Schizophr Bulletin, 2012;38:1180-1188. (IF 8.486)
  • Nieman DH, Velthorst E, Becker HE, de Haan L, Dingemans PM, Linszen DH, Birchwood M, Patterson P, Salokangas RKR, Heinimaa M, Heinz A, Juckel G, Graf van Reventlow H, Mosrrison A, Schulze Lutter F, Klosterkotter J, Ruhrmann S. The predictive value of the Strauss and Carpenter Prognostic Scale in subjects clinically at high risk for developing psychosis. Acta Psychiatrica Scandinavica. 2013;127(1):53-61 (IF 4.857)
  • van Tricht MJ, Nieman DH, Koelman JH, van der Meer JN, Bour LJ de Haan L, Linszen D. Course of P300 amplitudes in the prodrome and first episode of psychosis. World Journal of Biological Psychiatry 2012. DOI: 10.3109 (F 3.570)
  • Salokangas RK, Nieman DH, Heinimaa M, Svirskis T, Luutonen S, From T, von Reventlow HG, Juckel G, Linszen D, Dingemans P, Birchwood M, Patterson P, Schultze-Lutter F, Klosterkötter J, Ruhrmann S; Psychosocial outcome in patients at clinical high risk of psychosis: a prospective follow-up. Soc Psychiatry Psychiatr Epidemiol. 2013;48(2):303-11 (IF 2.861)
  • Ising HK, Veling W, Loewy RL, Rietveld, MW, Rietdijk J, Dragt S, Klaassen, RMC, Nieman DH, Wunderink L, Linszen DH, van der Gaag M. The development of the 16-item version of the Prodromal Questionnaire (PQ-16) to screen for ultrahigh risk for developing psychosis in the general help-seeking population. Schizophrenia Bulletin.2012; 38(6):1288-96. (IF 8.486)
  • Meijer JH, Swets M, Keeman S, Nieman DH, Meijer CJ and GROUP. Does a schizo-affective subtype exist from a cognitive perspective? Results from a large cross-sectional study in patients with psychosis and their unaffected relatives. Journal of Nervous and Mental Disease 2013;201(1):30-5. (IF 1.842).
  • Meijer JH, Schmitz N, Nieman DH, Becker HE, van Amelsvoort TAMJ, Dingemans PM, Linszen D.H, De Haan L. Semantic fluency deficits and grey matter differences before transition to psychosis: A voxelwise correlational analysis. Psychiatry Research Neuroimaging, 2011;194 (1):1-6. (IF 2.524)
  • Nieman DH, Sutterland AL, Otten J, Becker HE, Drent ML, de Haan L. Treating prolactinoma and psychosis: medication and cognitive behavioural therapy. British Medical Journal Case Reports 2011; doi 10.1136
  • Dragt S, Nieman D, Schultze-Lutter F, van der Meer F, Becker H, de Haan L, Dingemans PM, Birchwood M, Patterson P, Salokangas, MD, R, Heinimaa M, Heinz A, Juckel G, Graf von Reventlow H, French P, Stevens H, Ruhrmann S, Klosterkötter J, Don Linszen D, on behalf of the EPOS Group. Onset of cannabis use precedes onset of symptoms in subjects at clinical high risk for psychosis. Acta Psychiatrica Scandinavica 2012;125 (1):45-53. (IF 4.857)
  • Rietdijk J, Klaassen R, Ising H, Dragt S, Nieman DH, van de Kamp J, Cuijpers P, Linszen D, van der Gaag M, Detection of people at risk of developing a first psychosis: comparison of two recruitment strategies. Acta Psychiatrica Scandinavica 2012;126(1):21-30. (IF 4.857)
  • Velthorst E, Nieman DH, Veling W, Klaassen RM, Dragt S, Rietdijk J, Ising H, Wunderink L, Linszen DH, de Haan L, van der Gaag M, Ethnicity and baseline symptomatology in patients with an At Risk Mental State for psychosis. Psychological medicine 2011; 11:1-10. (IF 5.587)
  • Klaassen RMC, Velthorst E, Nieman DH, de Haan L, Becker HE, Dingemans PM, van de Fliert JR, van der Gaag M, Linszen DH, Factor Analysis of the Scale of Prodromal Symptoms: Differentiating between Negative and Depression Symptoms. Psychopathology 2011;44 (6):379-385. (IF 1.816)
  • Simon AE, Velthorst E, Nieman DH, Linszen D, Umbricht D, de Haan L, Ultra high-risk state for psychosis and non-transition: a systematic review. Schizophrenia Research 2011;132 (1):8-17 (IF4.748)
  • van Tricht MJ, Nieman DH, Koelman JHTM, Bour LJ, van der Meer JN, van Amelsvoort TA, Linszen DH, de Haan L, Auditory ERP components before and after transition to a first psychotic episode. Biological Psychology 2011;87 (3):350-357 (IF 3.225).
  • Velthorst E, Nieman DH, Meijer C, Linszen D, de Haan L, Social Disability at Admission for a First Psychosis Does Not Predict Clinical Outcome at 5-Year Follow-Up. J of Nerv and Ment dis 2011;199 (7):510-512 (IF 1.682)
  • Van Tricht MJ, Nieman DH, Koelman JHTM, Van der Meer J, Bour LJ, De Haan L, Linszen D. Reduced parietal P300 amplitude is associated with an increased risk for a first psychotic episode. Biological Psychiatry, 2010 1;68(7):642-648 (IF 8.674)
  • Velthorst E, Nieman D, Linszen D, Becker H, De Haan L, Dingemans P, Birchwood M, Patterson P, Salokangas R, Heinimaa M, Heinz A, Juckel G, Graf von Reventlow H, French P, Stevens H, Schultze-Lutter F, Klosterkötter J, Ruhrmann S. Disability in patients clinically at high risk for a psychosis. British Journal of Psychiatry 2010;197:278-84. (IF 5.947)
  • Velthorst E, Nieman DH, Klaassen RMC, Becker HE, Dingemans PM, Linszen DH, De Haan L. Three year course of clinical symptomatology in young people at ultra high risk for transition to psychosis. Acta Psychiatrica Scandinavica, 2011;123(1):36-42. (IF 4.220)
  • Dragt S, Nieman DH, Veltman D, Becker, HE, van de Fliert R, de Haan L, Linszen DH. Socio-demographic characteristics and social adjustment as predictors of a first psychosis in subjects at ultra high risk. Schizophrenia Research 2011;125(1):69-76. (IF4.748)
  • van Tricht MJ, Nieman DH, Bour LJ, Becker HE, Boeree T, Koelman J, Linszen DH. Increased saccadic rate during smooth pursuit eye movements in patients at ultra high risk for developing psychosis. Brain and cognition, 2010;73(3):215-21. (IF 2.838)
  • Niessen M, Dingemans PM, Becker HE, van de Fliert JR, Nieman DH, Linszen DH. Diagnostic validity of the Eppendorf Schizophrenia Inventory (ESI). A self-report ‘screen’ for UHR and acute psychosis. Psychological Assessment 2010; 22(4):935-44. (IF 2.589).
  • HE Becker, DH Nieman, S Wiltink, PM Dingemans, JR VD Fliert, De Haan L, TA van Amelsvoort, DH Linszen. Neurocognitive functioning before and after the first psychotic episode: Does psychosis result in cognitive deterioration? Psychological Medicine 2010; 5:1-8. (IF 5.012)
  • Van Tricht MJ, Nieman DH, Bour LJ, Boeree T; Koelman JH, De Haan L, Linszen DH. Increased saccadic rate during Smooth Pursuit Eye Movements in patients at Ultra High Risk for developing a psychosis. Brain and Cognition 2010;73(3):215-221. (IF 2.838)
  • Dragt, S. Nieman DH, Becker HE; Van de Fliert R, Dingemans PM, De Haan L, van Amelsvoort TA, Linszen DH. Age at onset of cannabis use is associated with age at onset of high-risk symptoms for psychosis. Canadian Journal of Psychiatry, 2010, 55(3): 165-171 (IF 2.418)
  • Bloeman OJ, de Koning MB, Schmitz N, Nieman DH, Becker HE, de Haan L, Dingemans P, Linszen DH, van Amelsvoort TA. White-matter markers for psychosis in a prospective ultra-high-risk cohort. Psychol Med. 2010 Aug;40(8):1297-304. (IF 5.200)
  • Korver N, Nieman DH, Becker HE, Van de Fliert JR, Dingemans PM, De Haan L, Spiering M, Schmitz N, Linszen DH. Symptomatology and neuropsychological functioning in cannabis using subjects at ultra high risk for developing psychosis and healthy controls. Australian and New Zealand Journal of Psychiatry, 2010 44(3) 230-6. (IF 2.481).
  • Becker HE, Nieman DH, Dingemans PM, van de Fliert JR, De Haan L, Linszen DH. Verbal fluency as a possible predictor for psychosis. Eur Psychiatry. 2010;25(2):105-10. (IF 3.365)\
  • Nieman DH, Rike WH, Becker HE, Dingemans PM, Van Amelsvoort TA, De Haan L, Van der Gaag M, Denys DA, Linszen DH. The prescription of antipsychotic medication to patients at ultra high risk for developing psychosis. International Clinical Psychopharmacology 2009;24:223-228. (IF 3.345)
  • Talamini LM, De Haan L, Nieman DH, Linszen DH, Meeter M. Reduced context effects on retrieval in first-episode schizophrenia. Plos One 2010;5(4):e10356 (IF 4.411)
  • Rietdijk J, Dragt S, Klaassen R, Ising H, Nieman D, Wunderink L, Delespaul P, Cuijpers P, Linszen D, van der Gaag M. A single blind randomized controlled trial of cognitive behavioural therapy in a help-seeking population with an At Risk Mental State for psychosis: the Dutch Early Detection and Intervention Evaluation (EDIE-NL) trial. Trials 2010;11(1):30. (IF 2.080)
  • de Koning MB, Bloemen OJN, van Amelsvoort TAMJ, Becker HE, Nieman DH, van der Gaag M, Linszen DH. Early intervention in patients at ultra high risk of psychosis: benefits and risks. Acta Psychiatrica Scandinavica 2009;119(6):426-442. (IF 3.733).
  • Velthorst E, Nieman DH, Becker HE, van de Fliert R, Dingemans PM, Klaassen R, de Haan L, van Amelsvoort T, Linszen DH. Baseline differences in clinical symptomatology between ultra high risk subjects with and without a transition to psychosis. Schizophrenia Research 2009;109(1-3):60-65. (IF 4.458)
  • Nieman D, Becker H, van de Fliert R, Plat N, Bour L, Koelman H, Klaassen M, Dingemans P, Niessen M, Linszen D. Antisaccade task performance in patients at ultra high risk for developing psychosis. Schizophrenia Research 2007;95(1-3):54-60. (IF 4.240)
  • Nieman DH, Koelman JHTM, Linszen DH, Bour LJ, Dingemans PM, Ongerboer de Visser BW. Clinical and neuropsychological correlates of the P300 in schizophrenia. Schizophrenia research 2002;55(1-2):105-113. (IF 3.203).
  • Nieman DH, Bour LJ, Linszen DH, Goede J, Koelman JH, Gersons BP, Ongerboer de Visser BW. Neuropsychological and clinical correlates of antisaccade task performance in schizophrenia. Neurology 2000;54(4):866-871. (IF 8.172)
  • Nieman DH, Ongerboer De Visser BW, Koelman JHTM, Hofman WF, Linszen DH The P3 event-related potential in young recent-onset schizophrenic patients. International Clinical Psychopharmacology. 1998;13:67-73. (IF 3.345)  

National (refereed) journals

  • Nieman DH, Van Der Gaag M. Cognitive behavioral therapy in patients with an increased risk of psychosis. Tijdschrift voor Psychiatrie (Journal of Psychiatry) 2008;50:69-70.
  • de Haan L, Velthorst E, Nieman DH, Becker HE, de Lange MA, van der Gaag M. Prevention of psychotic disorders; is the time ripe for intervention?].Ned Tijdschr Geneeskd. 2013;157(9):A5641.
  • Nieman D, Becker H, Gevers C, Linszen D. Cognitieve gedragstherapie (CGT) bij jongeren met risicosymptomen voor een psychose. (Cognitive behavioral therapy for youth with risk symptoms for a first psychosis). Kind en adolescent praktijk (Child and adolescent practice) 2007;6:4-9.
  • Klaassen MC, Nieman DH, Becker HE, Linszen DH. Wanneer heeft detectie van hoogrisicofactoren voor een eerste psychose zin? (Is there any point in detecting high risk factors prior to a first psychosis?) Tijdschrift voor Psychiatrie (Journal of Psychiatry) 2006;48(6):467-476. 
  • Nieman DH, Becker HE, Linszen DH. Psychotherapie bij (pre)psychotische patiënten. (Psychotherapy for (pre)psychotic patients. Kinder & jeugd psychotherapie (Child and Adolescent Psychiatry) 2004;4:59-66.
  • Nieman DH, Becker HE, Bour LJ, Linszen DH. Is schizofrenie te voorspellen? (Can schizophrenia be predicted?) Neuropraxis 2003; 7(2): 35-40.
  • Nieman DH. Neurofysiologisch en neuropsychologisch onderzoek bij patiënten met recent-ontstane schizofrenie. (Neurophysiological and neuropsychological research in patients with recent-onset schizophrenia. Nederlands Tijdschrift voor Neurologie (Dutch Journal for Neurology) 2002;5(1):68-69.
  • Nieman DH, Bour LJ, Linszen DH, Koelman JHTM, Ongerboer de Visser BW. Neurofysiologisch en neuropsychologisch onderzoek bij jonge patiënten met schizofrenie. Psychologie en computers: tijdschrift voor computer ondersteunde psychodiagnostiek en revalidatie 1998;15(2):44-54.
  • Engelsdorp Gastelaars H van, Nieman DH, Dingemans PMAJ. Een neuropsychologische testbatterij in onderzoek naar recent ontstane schizofrenie. Psychologie en computers: tijdschrift voor computer ondersteunde psychodiagnostiek en revalidatie 1998;15(3):83-95.

Book

  • Van der Gaag M, Nieman DH, Van den Berg D. 2013. 217p ISBN 978-0-415-53968-5. CBT for those at risk for a fist episode psychosis: Evidence based psychotherapy for people with an ‘At Risk Mental State’. Oxford, UK: Routledge.

Book chapters

  • Nieman DH, van Tricht MJ. Neurofysiologie (Neurophysiology). Handboek Schizofrenie (Handbook Schizophrenia) eds W. Cahn, L. Krabbendam, I. Myin-Germeys, R. Bruggeman, L. de Haan. 2011, pp 281-297. Utrecht: De Tijdstroom
  • Nieman DH, Meijer CJ, Staring T, van der Gaag M. Psychologische interventies. (Psychological Interventions). Handboek Vroege psychose (Handbook Early Psychosis), 2013, pp107-118. Eds W. Veling, D. Linszen, J. van Weeghel. Amsterdam: Uitgeverij SWP Amsterdam
  • Van der Gaag M, Boonstra N, Klaassen R, Rietdijk J, van der Berg D, Nieman DH. Ultrahoog risico voor het ontwikkelen van een eerste psychose. (Ultra high risk for developing psychosis). Handboek Vroege psychose, (Handbook Early Psychosis). 2013, pp18-29. Eds W. Veling, D. Linszen, J. van Weeghel.Amsterdam: Uitgeverij SWP Amsterdam

Abstracts

  • de Haan L, Velthorst E, van Tricht M, Becker HE, Nieman D. The social brain: social disability, cognitive deficits and event-related potentials in PRS. European Neuropsychopharmacology 2012; 21:S192
  • Mantione M, Nieman D, Schuurman R, Denys D. Neuropsychological effects of nucleus accumbens deep brain stimulation surgery for obsessive-compulsive disorder. European neuropsychopharmacology 2010;20:526-527.
  • Nieman D, Becker H, de Haan L, van der Gaag M, Denys D, Linszen D. Prescription of antipsychotic medication to patients at ultra high risk for developing psychosis in a naturalistic setting. Schizophrenia Research 2010; 117; 301.
  • Meijer JH, Schmtz N, Nieman DH, van Amelsvoort TA, Becker HE, de Haan L. The neuroanatomy of semantic verbal fluency deficits in individuals at ultra high risk for psychosis: implications for prediction. Biological Psychiatry 2009; 26:5.
  • Velthorst E, Nieman D, Becker H, van de Fliert R, Dingemans P, Klaassen R, de Haan L, van Amelsvoort T, Linszen D. Baseline differences in clinical symptomatology between ultra high risk subjects with and without a transition to psychosis. Schizophrenia Research 2010;117; 530.
  • Nieboer RM, Wunderink L, Boonstra N, Rietdijk J, Dragt S, Ising H, Klaassen R, Nieman D, van der Gaag M. Detection of patients at risk for psychosis by screening the help seeking population referred to mental health care services by self report questionnaire. Schizophrenia Research, 2010: 117: 301.
  • Dragt S., Nieman D.H., Becker H.E., Van De Fliert J.R., De Haan L., Linszen D.H. Environmental factors and social adjustment as predictors of a first psychosis in subjects at ultra high risk. Schizophrenia Research 2010;117 (2-3); 287
  • Bloemen O.J.N., De Koning M.B., Schmitz N., Nieman D.H., Becker H.E., Dingemans P., Linszen D.H., Van Amelsvoort T.A.M.J. Biological Psychiatry 2009;65 (8 SUPPL. 1);9.
  • Meijer J.H. Schmitz N. Nieman D.H. De Haan L. Becker H.E. Linszen D.H. Semantic fluency deficits and grey matter differences before transition to psychosis: A voxelwise correlational analysis. Schizophrenia Research. 2010;117 (2-3); 340.
  • Nieman DH, Becker HE, Van de Fliert JR, Plat NP, Bour LJ, Koelman JH, Dingemans PM, Linszen DH. Antisaccade task performance in patients at risk for developing psychosis. Schizophrenia Research 2006;81:267.
  • Nieman DH, Dragt S, Becker HE, Van de Fliert JR, Dingemans PM, Linszen DH. Cannabis abuse and or dependence at younger age relates to high risk symptoms for developing psychosis at younger age. Schizophrenia Research 2006;81:267.
  • Nieman DH, Becker HE, van de Fliert JR, Plat NP, Dingemans PM and Linszen DH. Disorganisation symptomatology and the P300 event related potential in ultra high risk patients: cross sectional and longitudinal data. Schizophrenia Research 2006:86:14
  • Nieman DH, Becker HE, van de Fliert JR, Plat NP, Niessen M, Klaassen MC, Dingemans PM, Linszen DH. Neurobiological abnormalities before and after the onset of psychosis: a P300 event-related potential study. Schizophrenia Research 2006;86:70-71.
  • Becker HE, Nieman DH, van de Fliert JR, Dingemans PM, Linszen DH. Cognitive functioning in patients at ultra high risk for a first episode of psychosis: Relation to daily life functioning Schizophrenia Research 2006;81:259.
  • Becker HE, Nieman DH, van de Fliert JR, Dingemans PM, Linszen DH. Cognitive functioning in patients at ultra high risk for developing Schizophrenia Research 2006;81:259.
  • Niessen MA, Dingemans PMAJ, Becker HE, van de Fliert JR, Nieman DH, Linszen DH. Validity of the Eppendorfer schizophrenia inventory (ESI) as a screening device in high risk assessment. Schizophrenia Research, 2006;86: 80
  • Klaassen MC, Nieman DH, de Haan L, Becker HE, Dingemans PM, Linszen DH, van de Fliert R. Differentiation between depressive and negative symptoms in patients at ultra high risk for psychosis Schizophrenia Research, 2006;86:81-82.
  • Van de Fliert JR, Becker HE, Nieman DH, Dingemans PM, Niessen MA, Linszen DH, Patients at high risk for psychosis: level of functioning and handicaps of the transition and non-transition group Schizophrenia Research 2006;81:272.
  • Dingemans PM, Becker HE, van de Fliert JR, Niessen MA, Nieman DH, Linszen DH, Ruhrmann S, Heinimaa M, Patterson P, Graf von Reventlow H et al. Personality pathology traits and risk for psychosis Schizophrenia Research 2006;86:94.
  • Becker HE, Nieman DH, van de Fliert JR, Dingemans PM, Linszen. Patients at high risk for psychosis: Verbal Fluency. Schizophrenia Research 2006;86:94.
  • Van de Fliert JR, Becker HE, Linszen DH., Dingemans PM, Nieman DH, van Benthem R, Menninga SM, Klaassen MC. Patients at high risk for psychosis: Baseline symptomatology. European Psychiatry 2004;19:199.
  • Becker HE, Nieman DH, van de Fliert JR, Dingemans P, Linszen DH. Cannabis use and misuse in patients at ultra high risk for psychosis. European Psychiatry 2004;19:199.
  • Nieman DH, Bour LJ, van de Fliert JR, Klaassen MC, Becker HE, Plat N, Dingemans PM, Linszen DH. Eye movement abnormalities in patients at risk for developing psychosis. European Psychiatry 2004;19:23.
  • Nieman DH, Linszen DH. Memory performance at onset may be predictive of the course of schizophrenia. Schizophrenia Research 2003;60(1):151.
  • Nieman DH, Bour LJ, Linszen DH, Ongerboer de Visser BW. Restricted visual scan patterns are related to working memory deficits in recent-onset schizophrenia. Schizophrenia Research 2001;49:217.
  • Nieman DH, Koelman JHTM, Linszen DH, Bour LJ, Dingemans PM, Ongerboer de Visser BW. The P300 event-related potential: correlations with memory impairment and negative symptomatology. Schizophrenia Research 2000;41:152.
  • Nieman DH, Bour LJ, Goede J, Linszen DH, Gersons BPR, Ongerboer de Visser BW. Visual scanning and antisaccades in recent onset schizophrenic patients: correlations with working memory deficits and visual attention. Journal of Psychophysiology 2000;14:S51-S52. 
  • Nieman DH, Bour LJ, Goede J, Linszen DH, Gersons BPR, Ongerboer de Visser BW. Visual scanning in recent-onset schizophrenia: relationship with the antisaccade task and working memory deficits. Behavioral Pharmacology 2000;11:345.
  • Nieman DH, Bour LJ, Linszen DH, Goede J, Ongerboer de Visser BW. Neuropsychological and clinical correlates of antisaccade task performance in young recent-onset schizophrenic patients. Schizophrenia Research 1999;36:265.
Research programmes

New, evidence-based, transdiagnostic treatments in psychiatry

Although psychiatric disorders are common in the general population worldwide, their causes are still poorly understood. The diagnostic categories in the most widely used classification system in clinical practice (i.e. the DSM) are based on expert consensus. However, biological (cognitive, genetic, neurophysiological, neuroimaging, blood marker, etc.) dysfunctions underlying psychiatric disorders, are not specific for these diagnostic categories. One aim of our research is to investigate transdiagnostic biological dysfunctions underlying psychiatric disorders and new treatments for these dysfunctions. An example is a recently started RCT that investigates cognitive remediation in schizophrenia, depression or obsessive-compulsive disorder with an online serious game.

Furthermore, early detection and treatment of psychiatric disorders can improve prognosis. We investigate prediction models that can enhance prediction accuracy of developing a severe mental disorder in symptomatic, help-seeking patients at risk and new, evidence-based treatments which can be offered to these patients.
 

Faculty
Dr. D.H. Nieman

Postdocs
Dr. M.C. Klaassen (de Bascule)
Dr. M.J. van Tricht (Arkin)

PhD Students
Drs. H.E. Becker MD
Drs. A.C. Domen
Drs. B. Sterk MD
A.M. Tedja
Y.M. Wong

Prof. dr. L. de Haan (Recent onset schizophrenia)