Dr. D.J. Stenvers

Main activities
Patient care, Research
Endocrinology and metabolism
Focus of research

The circadian timing system consists of a central brain clock and peripheral clocks in metabolic organs such as liver, pancreas and adipose tissue. The circadian system receives direct information about light and darkness from the retina, and synchronises energy metabolism with the 24-hour rhythms of light/darkness and feeding/fasting. In present society, disruption of the circadian synchrony between the 24-hour rhythms of central and peripheral clocks, hormones, the autonomic nervous system, light/dark exposure, sleep/wake behaviour and food intake may contribute to the pandemic of obesity and type 2 diabetes. Dr. Stenvers' research focuses on the use of circadian knowledge to improve human metabolic health.

Key publications
  • Stenvers DJ, Scheer FAJL, Schrauwen P, la Fleur SE, Kalsbeek A, Circadian clocks and insulin resistance. NAT REV ENDOCRINOL 2018;-:- [PubMed]
  • Opperhuizen AL, Stenvers DJ, Jansen RD, Foppen E, Fliers E, Kalsbeek A, Light at night acutely impairs glucose tolerance in a time-, intensity- and wavelength-dependent manner in rats. DIABETOLOGIA 2017;60 (7):1333-1343 [PubMed]
  • Stenvers DJ, van Dorp R, Foppen E, Mendoza J, Opperhuizen AL, Fliers E, Bisschop PH, Meijer JH, Kalsbeek A, Deboer T, Dim light at night disturbs the daily sleep-wake cycle in the rat. SCI REP-UK 2016;6:35662 [PubMed]
  • Stenvers DJ, Schouten LJ, Jurgens J, Endert E, Kalsbeek A, Fliers E, Bisschop PH, Breakfast replacement with a low-glycaemic response liquid formula in patients with type 2 diabetes: a randomised clinical trial. BRIT J NUTR 2014;112 (4):504-512 [PubMed]
All Publications