Dr. D.M. de Bruin MSc PhD

Scientific staff member (UD)
Main activities
optics, photonics, focal therapy, clinical translation
Focus of research

1) Digital pathology, funded by ITEA

2) quantitative analysis of data using i.e. a convolutional neural networks (CNN), funded by ITEA.

3) Imaging using contrast enhanced endoscopy, optical coherence tomography (OCT) and con-focal laser endomicroscopy (CLE) during interventions, funded by ZonMW and cure for cancer (CFC).

4) Functional (in vivo) optical imaging of malignant and benign disease, funded by ZonMW and cure for cancer (CFC).

5) Design and development of new minimally invasive optical devices for in vivo use, funded by STW.

6) Focal therapy of malignancies using irreversible electroporation (IRE), funded by CFC.

7) Clinical Translation and intergration.

Key publications
  • Cauberg ECC, de Bruin DM, Faber DJ, van Leeuwen TG, de La Rosette JJMCH, de Reijke TM, A new generation of optical diagnostics for bladder cancer: technology, diagnostic accuracy, and future applications. EUR UROL 2009;56 (2):287-296 [PubMed]
  • Wijmans L, de Bruin DM, Meijer SL, Annema JT, Real-Time Optical Biopsy of Lung Cancer. AM J RESP CRIT CARE 2016;194 (8):e10-e11 [PubMed]
  • Bus MTJ, de Bruin DM, Faber DJ, Kamphuis GM, Zondervan PJ, Laguna-Pes MP, van Leeuwen TG, de Reijke TM, de la Rosette JJMCH, Optical Coherence Tomography as a Tool for In Vivo Staging and Grading of Upper Urinary Tract Urothelial Carcinoma: A Study of Diagnostic Accuracy. J UROLOGY 2016;196 (6):1749-1755 [PubMed]
  • Baard J, de Bruin DM, Zondervan PJ, Kamphuis G, de la Rosette J, Laguna MP, Diagnostic dilemmas in patients with upper tract urothelial carcinoma. NAT REV UROL 2017;14 (3):181-191 [PubMed]
  • de Bruin DM, Broekgaarden M, van Gemert MJC, Heger M, de la Rosette JJ, van Leeuwen TG, Faber DJ, Assesment of apoptosis induced changes in scattering using optical coherence tomography. J BIOPHOTONICS 2016;9 (9):913-923 [PubMed]
All Publications
Curriculum Vitae

Daniel Martijn de Bruin is a staff member, performing translational research at both the department of Urology and the photonics group of the department of Biomedical Engineering & Physics of the AMC. His task is to initiate new research that will ultimately result in minimal invasive optical diagnostic device that allows diagnosis of disease. 


Martijn studied photonics and laser-optics at Technical College Ede. After graduation, he studied molecular biology (BSC) at Hogeschool Utrecht which was finished with a full year research internship at the Wellman Center for Photomedicine, Harvard Medical School. Subsequently, he received his Master degree (MSc) in Medical Biochemistry from the University of Amsterdam. While obtaining his Masters, Martijn finished his doctorate (PhD) at the department of biomedical engineering & physics (BMEP) at the Academic Medical Center (AMC).


His projects revolve around digital pathology using convolutional neural networks as computer aided diagnosis for pathologists, optical coherence tomography (OCT), con-focal laser endomicroscopy which are both novel clinical imaging techniques that enables minimal invasive optical biopsy and irrversible electroporation (IRE) an novel interventional treatment for cancer. Besides understanding and engineering the basic technologies involved, the photonics group partially leaped the gap that existed between new optical clinical imaging technologies and the everyday clinical reality. This resulted in new and successful collaborations between the department of BMEP and departments such as Urology, Cardiology, Surgery and Radiotherapy within the AMC. Moreover, other hospitals such as the Dutch Cancer Institute (NKI), the Vrije Universiteit medical center (VUmc) and international hospitals are involved in their projects as well.


Research programmes

Prof. dr. A.G.J.M. van Leeuwen MSc PhD (Biomedical photonics for functional and molecular imaging)

Other research related activities
  • Board of directors / Trustees / Supervisory board, Offroad Medical BV
Current research funding
  • Elesta S.r.L.
  • Personeelsproject - Industrie
  • Stichting Cure for Cancer