Dr. D.M.J. Milstein

Scientific staff member (UD)
Main activities
Oral & Maxillofacial Diagnostics, Translational Research
Focus of research

Research in cardiovascular physiology, surgery, and oral & maxillofacial specialties with a particular focus on tissue oxygenation, microcirculation, (orapathology, regeneration, and oral diagnostic sciences. Research projects include studies in hyperbaric medicine for wound healing, ischemia-reperfusion injuries, osteoradionecrosis & medication-related osteonecrosis of the jaw, photodynamic therapy for head & neck malignancies, clinical value of monitoring perioperative patient microcirculation, and evaluating the influences of both oral prosthesis and their materials on normal and pathological lesions.


Key publications
  • Tytgat SHAJ, van der Zee DC, Ince C, Milstein DMJ, Carbon dioxide gas pneumoperitoneum induces minimal microcirculatory changes in neonates during laparoscopic pyloromyotomy. SURG ENDOSC 2013;27 (9):3465-3473 [PubMed]
  • Milstein DMJ, van Kuijen AM, Copper MP, Karakullukçu B, Tan IB, Lindeboom JAH, Fokkens WJ, Ince C, Monitoring microcirculatory alterations in oral squamous cell carcinoma following photodynamic therapy. PHOTODIAGN PHOTODYN 2012;9 (1):69-75 [PubMed]
  • Milstein DMJ, te Boome LCJ, Cheung YW, Lindeboom JAH, van den Akker HP, Biemond BJ, Ince C, Use of sidestream dark-field (SDF) imaging for assessing the effects of high-dose melphalan and autologous stem cell transplantation on oral mucosal microcirculation in myeloma patients. ORAL SURG ORAL MED O 2010;109 (1):91-97 [PubMed]
  • Milstein DMJ, Bezemer R, Lindeboom JAH, Ince C, The acute effects of CMF-based chemotherapy on maxillary periodontal microcirculation. CANCER CHEMOTH PHARM 2009;64 (5):1047-1052 [PubMed]
  • Milstein DMJ, Mathura KR, Lindeboom JAH, Ramsoekh D, Lindeboom R, Ince C, The temporal course of mucoperiosteal flap revascularization at guided bone regeneration-treated implant sites: a pilot study. J CLIN PERIODONTOL 2009;36 (10):892-897 [PubMed]
All Publications
Research programmes

Prof. dr. C. Ince (Cardiovascular aspects of Surgery and Critical Illness)

Other research related activities
  • Contribution to training of professionals, University of Amsterdam
  • Contribution to guidelines and protocols, Microcirculation research