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Dr. E.N.T.P. Bakker

Position
Scientific staff member (UD)
Main activities
Research, Teaching
Specialisation
Vascular Biology
Focus of research

Experimental work on vascular remodeling associated with altered blood flow, hypertension and atherosclerosis. Role of vascular tone, inflammation and transglutaminases in arterial remodeling.

Currently I focus on the role of the brain vasculature in cognitive function. In particular, I am interested in the perivascular pathway of amyloid beta removal. The characteristics, its driving force, and impact of vascular pathology on this transport pathway are currently unknown and of great potential importance in the development of dementia.

Key publications
  • Bedussi B, Naessens DMP, de Vos J, Olde Engberink R, Wilhelmus MMM, Richard E, ten Hove M, VanBavel E, Bakker ENTP, Enhanced interstitial fluid drainage in the hippocampus of spontaneously hypertensive rats. SCI REP-UK 2017;7 (1):744 [PubMed]
  • Bedussi B, van der Wel NN, de Vos J, van Veen H, Siebes M, VanBavel E, Bakker ENTP, Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways. J CEREBR BLOOD F MET 2017;37 (4):1374-1385 [PubMed]
  • Bedussi B, Almasian M , de Vos J, VanBavel E, Bakker ENTP, Paravascular spaces at the brain surface: Low resistance pathways for cerebrospinal fluid flow. J CEREBR BLOOD F MET 2018;38 (4):719-726 [PubMed]
  • Palao T, Rippe C, van Veen H, VanBavel E, Swärd K, Bakker ENTP, Thrombospondin-4 knockout in hypertension protects small-artery endothelial function but induces aortic aneurysms. AM J PHYSIOL-HEART C 2016;310 (11):H1486-H1493 [PubMed]
  • Palao T, Swärd K, Jongejan A, Moerland PD, de Vos J, van Weert A, Arribas SM, Groma G, VanBavel E, Bakker ENTP, Gene Expression and MicroRNA Expression Analysis in Small Arteries of Spontaneously Hypertensive Rats. Evidence for ER Stress. PLOS ONE 2015;10 (9):e0137027 [PubMed]
All Publications
Curriculum Vitae

1988-93 Biology University of Leiden. Masters degree: 10-8-93
1993-98 PhD project Dept. of Physiology, VUMC. Thesis: Regulation of vascular tone by endothelial factors in isolated arterioles. PhD degree: 9-6-98
1998-2001 Post-doc Medical Physics, AMC. Topic: structural and functional adaptation of arterioles.
2001-2002 Marie Curie Fellowship, European Union. Dept. Of Pharmacology, University of Aarhus, Aarhus, Denmark. Title: Microvascular remodeling: structure follows function?
2002-2006 Dekker Fellowship Netherlands Heart Foundation. Dept. Medical Physics, AMC. Topic: Mechanisms of coronary microvascular remodeling.
2006-2008 Dekker Fellowship Netherlands Heart Foundation, continuation and extension with PhD project: “The role of transglutaminases in the progression of atherosclerosis”.
2008- Assistant Professor, Dept. of Biomedical Engineering and Physics, AMC.
 

Current research funding
  • Stichting Alzheimer Nederland