Dr. G. Stokman

Main activities
Tubular epithelial cell injury and repair.
Focus of research

Role of Exchange Protein directly Activated by cAMP (Epac) in tubular damage and nephrotoxicity.

Toll-like receptors drive tubular repair by regulating Wnt expression and epithelial morphogenesis.



Key publications
  • Stokman G, Qin Y, Genieser HG, Schwede F, de Heer E, Bos JL, Bajema IM, van de Water B, Price LS, Epac-Rap signaling reduces cellular stress and ischemia-induced kidney failure. J AM SOC NEPHROL 2011;22 (5):859-872 [PubMed]
  • Stokman G, Qin Y, Rácz Z, Hamar P, Price LS, Application of siRNA in targeting protein expression in kidney disease. ADV DRUG DELIVER REV 2010;62 (14):1378-1389 [PubMed]
  • Stokman G, Leemans JC, Claessen N, Weening JJ, Florquin S, Hematopoietic stem cell mobilization therapy accelerates recovery of renal function independent of stem cell contribution. J AM SOC NEPHROL 2005;16 (6):1684-1692 [PubMed]
  • Leemans JC, Stokman G, Claessen N, Rouschop KM, Teske GJD, Kirschning CJ, Akira S, van der Poll T, Weening JJ, Florquin S, Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J CLIN INVEST 2005;115 (10):2894-2903 [PubMed]
  • Stokman G, Qin Y, Booij TH, Ramaiahgari S, Lacombe M, Dolman MEM, van Dorenmalen KMA, Teske GJD, Florquin S, Schwede F, van de Water B, Kok RJ, Price LS, Epac-Rap signaling reduces oxidative stress in the tubular epithelium. J AM SOC NEPHROL 2014;25 (7):1474-1485 [PubMed]
All Publications
Research programmes

Prof. dr. S. Florquin (Renal inflammation and repair)