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Dr. H.A. Marquering

Position
Associate professor (UHD)
Main activities
Research, Teaching
Specialisation
Cardiovascular Imaging and Image Analysis
Focus of research

The focus of my research is the application of Artificial Intelligence on medical image analyses, and 3D and 4D cardiovascular images in particular. The research encompasses GOFAI (good old-fashioned artificial intelligence) as well as the more novel deep learning / convolutional neural networks approaches. A strong focus is on neurovascular image analysis for diagnosis, prognostics and treatment decision support of patients suffering from (acute ischemic or hemorrhagic) stroke.

Moreover, our research group works on heterogeneous data analysis in which radiological image data is combined with other types (clinical, baseline, lab) data to enhance prognostics. Since our research group is working for a long time on digital image analysis, other aspects of the digitization is also of our interest. Such subjects include image logistics and exchange, privacy and security, and collaboration with ambulances in the hyper-acute situations.

Key publications
  • Marquering HA, van Ooij P, Streekstra GJ, Schneiders JJ, Majoie CB, VanBavel E, Nederveen AJ, Multiscale flow patterns within an intracranial aneurysm phantom. IEEE T BIO-MED ENG 2011;58 (12):3447-3450 [PubMed]
  • Marquering H, Dahlen FA, Nolet G, Three-dimensional sensitivity kernels for finite-frequency traveltimes: the banana-doughnut paradox. GEOPHYS J INT 1999;137 (3):805-815
  • Santos EMM, Dankbaar JW, Treurniet KM, Horsch AD, Roos YB, Kappelle LJ, Niessen WJ, Majoie CB, Velthuis B, Marquering HA [Contributors: Duijm LE, Keizer K, van der Lugt A, Dippel DW, Droogh-de Greeve KE, Bienfait HP, van Walderveen MA, Wermer MJ, Lycklama à Nijeholt GJ, Boiten J, Duyndam D, Kwa IV, Meijer JF, van Dijk EJ, Kesselring FO, Hofmeijer J, Vos JA, Schonewille WJ, van Rooij WJ, de Kort PL, Pleiter CC, Bakker SL, Bot J, Visser MC, van der Schaaf IC, Mali WP, van Seeters T, Niesten JM, Biessels GJ, Luitse MJ, van der Graaf Y]] , Permeable Thrombi Are Associated With Higher Intravenous Recombinant Tissue-Type Plasminogen Activator Treatment Success in Patients With Acute Ischemic Stroke. STROKE 2016;47 (8):2058-2065 [PubMed]
  • Bucker A, Boers AM, Bot JCJ, Berkhemer OA, Lingsma HF, Yoo AJ, van Zwam WH, van Oostenbrugge RJ, van der Lugt A, Dippel DWJ, Roos YBWEM, Majoie CBLM, Marquering HA, Associations of Ischemic Lesion Volume With Functional Outcome in Patients With Acute Ischemic Stroke: 24-Hour Versus 1-Week Imaging. STROKE 2017;48 (5):1233-1240 [PubMed]
  • Elattar MA, Wiegerinck EM, Planken RN, VanBavel E, van Assen HC, Baan J Jr, Marquering HA, Automatic segmentation of the aortic root in CT angiography of candidate patients for transcatheter aortic valve implantation. MED BIOL ENG COMPUT 2014;52 (7):611-618 [PubMed]
All Publications
Curriculum Vitae

Henk Marquering defended his PhD at the Utrecht University in 1996 on Surface-wave mode coupling: Modelling and inverting waveforms including body-wave phases. He continued his work on theoretical seismology as a post-doc in Princeton University. Here he worked on the rather controversial "banana-doughnut kernels".

He returned to the Netherlands in 1998 to work as a researcher in the R&D department of Oce. During the 5 years that he worked here his focus was on document analysis, and image processing, most noticeably on the segmentation of Japanese newspapers.

 In 2003 he joined the LKEB department of the LUMC. Here he started working on the segmentation of coronary arteries in multi-slice CT images. His work resulted in a market introduction of Medis software on CT based stenosis quantification of carotid arteries.

 In 2008 he joined 3mensio as a researcher/programmer where he mainly worked on the introduction of 3mensio's software for the measurements for sizing and patient selection for the transcatheter aortic valve implantation (TAVI).

In September he started at the Radiology department and the Biomedical Engineering and Physics department of the Amsterdam UMC, location AMC. He is currently an associate professor and principal investigator in cardiovascular imaging and image analysis. Part of his research focusses on the application of machine learning and artifical intellligence for the analysis of radiological images. He was involved in 4 CARISMA and 1 HTSM STW projects. He was project leader of PAPAVER and the NutsOhra funded project Q-SAB.  He is and was involved in multiple ITEA projects sucha as MEDUSA , 3DpathologyMedolution, and PARTNER. Henk is also co-chairing the H2020 project INSIST forcussing on In-silico clinical trials for treatment of stroke. Recently he also got involved in two securiy-based H2020 projects; Safecare and Asclepios.

Henk is a cofounder of Nico-lab, an AMC spin-off AI company that focusses on the automated analysis of images of patients suspected of stroke. With Nico.lab the AMC has succesfully set up awarded collaborative projects such as STW take off (1 and 2), ANIMATIONS, BRAINS, ARCADES.

Henk Marquering is (co)author of over 125 peer-reviewed papers, has a H-factor of 32 (google scholar) and has two patents on the segmentation of japanese newspaper: Segmenting an image via a graph; Patent number: 7570811 and Segmenting an image via shortest cycles; Patent number: 7529407.

Henk also was part of the start of thrombus pervious research. And here you can find some of his old work on banana-doiughnut kernels.

 

 

Research programmes

Cardiovascular image analysis

My research focuses on the application of Artificial Intelligence for quantitative image analysis for (1) computer aided diagnosis, (2) treatment selection, (3)  minimal invasive treatment planning, and (4) improving prognostics. Within this field, I have a special interest in neurovascular image analysis and ischemic and hemorrhagic stroke.

Faculty
Dr. H.A. Marquering
M.W.A. Caan

PhD Students
N. Arrarte Terreros
A.M.M. Boers (Univerisity Twente)
B.R. Boti MSc
B.M.W. Cornelissen MSc (Universiteit Twente)
Drs. A.E.D. Groot MD
I. Jansen
M. Kappelhof MD
P.R. Konduri
K.R. van Kranendonk
E.L. Leemans MSc
M. Lucas
H. Prasetya MEng
L.A. Ramos
R. Ricci Lopes MSc
R. Sales Barros MSc
Drs. W.E. van der Steen MD
T. Tervoort
M.L. Tolhuisen MSc
K.M. Treurniet
M. Tuler de Oliveira
H. van Voorst MD MSc
R. Zoetmulder

Prof. dr. C.B.L.M. Majoie (Neuroradiology, Neurovascular diseases: imaging and endovascular treatment of acute stroke)

Dr. J. Baan MD PhD (Transcatheter Heart Valve Interventions)

Other research related activities
  • Membership of medical or scientific committee, CCVW, UvA
  • Coordinator MIK-BAM3.3, University of Amsterdam
  • Examinator opleiding Bachelor Natuur- en Sterrenkunde, University of Amsterdam
  • Examiner for master Physics, University of Amsterdam
  • Examinator Medische informatiekunde, University of Amsterdam
  • BKO certified teacher, Evidence-based education
  • Member, NVPHBV
  • Stock / Shareholder, NICo-Lab (www.nico-lab.com)
Current research funding
  • AMC
  • Europese Unie
  • IPPMed Inst.für Pharmakologie und praeventive Medizin GmbH
  • Life Sciences Health TKI
  • Rijksdienst voor Ondernemend Nederland
  • Technologiestichting STW