Dr. H.G. Ruhé

Main activities
Patient care, Research
Psychiatry, Mood disorders, Pharmacology, Treatment resistance, Neuroimaging
Focus of research

My focusof research is the treatment of Major Depressive Disorder, and especially when patients do not respond to first and second line treatment (treatment resistant depression).

In order to better understand and quantify the brain mechanisms underlying treatment resistant depression, I use neuroimaging approaches like SPECT and fMRI.

Besides I am interested in using neuroimaging as a tool for inprovement of diagnosis in psychiatry, again focussed on mood disorders like Major Depressive Disorder and Bipolar Disorder

Key publications
  • Ruhé HG. Dose-escalation in the picture. Pharmacological and imaging studies in depression. s.l.: s.n.; 2008. 300p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Schene AH; copromotor(s): Booij J)
  • Ruhe HG, Mason NS, Schene AH, Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies. MOL PSYCHIATR 2007;12 (4):331-359 [PubMed]
  • Ruhé HG , Booij J, Weert HCV, Reitsma JB, Fransen EJF, Michel MC, Schene AH, Evidence Why Paroxetine Dose Escalation is Not Effective in Major Depressive Disorder: A Randomized Controlled Trial With Assessment of Serotonin Transporter Occupancy. NEUROPSYCHOPHARMACOL 2009;34 (4):999-1010 [PubMed]
  • Ruhé HG , Huyser J, Swinkels JA, Schene AH, Switching antidepressants after a first selective serotonin reuptake inhibitor in major depressive disorder: a systematic review. J CLIN PSYCHIAT 2006;67 (12):1836-1855 [PubMed]
  • Ruhé HG , Huyser J, Swinkels JA, Schene AH, Dose escalation for insufficient response to standard-dose selective serotonin reuptake inhibitors in major depressive disorder: systematic review. BRIT J PSYCHIAT 2006;189:309-316 [PubMed]
All Publications
Curriculum Vitae

Available on request