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Dr. J. den Dunnen PhD

Position
Scientific staff member (UD)
Main activities
Research
Specialisation
Immunology
Focus of research

Investigating the role of Fc receptors on myeloid cells during bacterial infections, rheumatoid arthritis, and inflammatory bowel disease.

Key publications
  • Hansen IS, Baeten DLP , den Dunnen J, The inflammatory function of human IgA. CELL MOL LIFE SCI 2018;ahead of print [PubMed]
  • Hansen IS, Krabbendam L, Bernink JH, Loayza-Puch F, Hoepel W, van Burgsteden JA, Kuijper EC, Buskens CJ, Bemelman WA, Zaat SAJ, Agami R, Vidarsson G, van den Brink GR, de Jong EC, Wildenberg ME, Baeten DLP , Everts B, den Dunnen J, + dendritic cells into pro-inflammatory cells through glycolytic reprogramming. NAT COMMUN 2018;9 (1):863 [PubMed]
  • Hansen IS, Hoepel W, Zaat SAJ, Baeten DLP , den Dunnen J, Serum IgA Immune Complexes Promote Proinflammatory Cytokine Production by Human Macrophages, Monocytes, and Kupffer Cells through FcαRI-TLR Cross-Talk. J IMMUNOL 2017;199 (12):4124-4131 [PubMed]
  • Vogelpoel LTC, Hansen IS, Rispens T, Muller FJM, van Capel TMM, Turina MC, Vos JB, Baeten DLP , Kapsenberg ML, de Jong EC, den Dunnen J, Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages. NAT COMMUN 2014;5:5444 [PubMed]
  • den Dunnen J, Vogelpoel LTC, Wypych T, Muller FJM, de Boer L, Kuijpers TW, Zaat SAJ, Kapsenberg ML, de Jong EC, IgG opsonization of bacteria promotes Th17 responses via synergy between TLRs and Fc gamma RIIa in human dendritic cells. BLOOD 2012;120 (1):112-121 [PubMed]
All Publications
Research programmes

Fc receptor induced inflammation

 My group studies the induction of inflammation by Fc receptors during bacterial infections, rheumatoid arthritis, and inflammatory bowel disease, with the aim to identify new targets for therapy of these diseases.

Faculty
Dr. J. den Dunnen PhD

PhD Students
J.W. Hoepel MSc
M. Newling

Prof. dr. D.L.P. Baeten (Immunopathology of chronic inflammatory arthritis)

Current research funding
  • AMC (Vrijgesteld)
  • Stichting ReumaNederland