Dr. J.C. Villaudy PhD

Main activities
Humanized mouse system
Focus of research

I focus my research on the use of humanized mice in several field of biomedical research. These mice are able to develop human immune system that makes them a great model to study pathologies involving the immune system. 

In collaboration with other department of the AMC, I use these mice to study cardiovascular diseases, immuno-oncology and virology.

COBRA (CO-morBidity in Relation to AIDS) is a UE-funded project aiming at better understanding the link between HIV infection, antiretroviral therapy and the developement of Age-associated non communicable comorbidities. Within this project, I am trying to establish the causative effect of HIV infection and antiretroviral therapy on metabolic, immunologic and ageing changes using a humanized mouse model. Those mice are susceptible to HIV infection and therapy. 

Key publications
  • Villaudy J, Schotte R, Legrand N, Spits H, Critical assessment of human antibody generation in humanized mouse models. J IMMUNOL METHODS 2014;410:18-27 [PubMed]
All Publications
Research programmes

Prof. dr. B. Berkhout (Virology)

Prof. dr. P. Reiss MD PhD (Complications of HIV and HIV treatment)

Other research related activities
  • Scientist, AIMM Therapeutics