I focus my research on the use of humanized mice in several field of biomedical research. These mice are able to develop human immune system that makes them a great model to study pathologies involving the immune system.
In collaboration with other department of the AMC, I use these mice to study cardiovascular diseases, immuno-oncology and virology.
COBRA (CO-morBidity in Relation to AIDS) is a UE-funded project aiming at better understanding the link between HIV infection, antiretroviral therapy and the developement of Age-associated non communicable comorbidities. Within this project, I am trying to establish the causative effect of HIV infection and antiretroviral therapy on metabolic, immunologic and ageing changes using a humanized mouse model. Those mice are susceptible to HIV infection and therapy.