Dr. J.H.M. Levels PhD

Main activities
Lipid metabolism, Proteomics, Hemostasis
Focus of research

Hemostasis and  Lipid Metabolism

Key publications
  • Raterman HG, Levels H, Voskuyl AE, Lems WF, Dijkmans BA, Nurmohamed MT, HDL protein composition alters from proatherogenic into less atherogenic and proinflammatory in rheumatoid arthritis patients responding to rituximab. ANN RHEUM DIS 2013;72 (4):560-565 [PubMed]
  • Levels JHM, Geurts P, Karlsson H, Maree R, Ljunggren S, Fornander L, Wehenkel L, Lindahl M, Stroes ESG, Kuivenhoven JA, Meijers JCM, High-density lipoprotein proteome dynamics in human endotoxemia. PROTEOME SCI 2011;9 (1):34 [PubMed]
  • Holleboom AG, Karlsson H, Lin RS, Beres TM, Sierts JA, Herman DS, Stroes ESG, Aerts JM, Kastelein JJP, Motazacker MM, Dallinga-Thie GM, Levels JHM, Zwinderman AH, Seidman JG, Seidman CE, Ljunggren S, Lefeber DJ, Morava E, Wevers RA, Fritz TA, Tabak LA, Lindahl M, Hovingh GK, Kuivenhoven JA, Heterozygosity for a loss-of-function mutation in GALNT2 improves plasma triglyceride clearance in man. CELL METAB 2011;14 (6):811-818 [PubMed]
  • Bartuzi P, Billadeau DD, Favier R, Rong S, Dekker D, Fedoseienko A, Fieten H, Wijers M, Levels JH, Huijkman N, Kloosterhuis N, Van der Molen H, Brufau G, Groen AK, Elliott AM, Kuivenhoven JA, Plecko B, Grangl G, McGaughran J, Horton JD, Burstein E, Hofker MH, van de Sluis B, CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. NAT COMMUN 2016;7:10961 [PubMed]
  • Fedoseienko A, Wijers M, Wolters JC, Dekker D, Smit M, Huijkman N, Kloosterhuis N, Klug H, Schepers A, Willems van Dijk K, Levels JHM, Billadeau DD, Hofker MH, van Deursen J, Westerterp M, Burstein E, Kuivenhoven JA, van de Sluis B, The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking. CIRC RES 2018;122 (12):1648-1660 [PubMed]
All Publications
Curriculum Vitae

1987: HLO Technician, training at ZLS Zuid Nederland


1996: Master in Chemistry, Biochemistry (Faculty of Chemistry, University of Amsterdam)


2002: PhD. Thesis: Lipoproteins in innate immunity. (Faculty of Medicine, University of Amsterdam)


Research programmes

Prof. dr. M. Nieuwdorp MD PhD (Gutmicrobiota as novel diagnostic and therapeutic targets in cardiometabolism)