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Dr. J.J.T.H. Roelofs MD PhD

Position
Associate professor (UHD)
Main activities
Patient care, Research
Specialisation
Pathologist
Focus of research

Reciprocal interactions between coagulation and inflammation in the context of kidney diseases.

Current research programmes:

  1. The fibrinolytic system in renal disease
  2. Active Protein C (APC) and the endothelial protein C receptor (EPCR) in acute kidney injury and renal allograft rejection
  3. APC and EPCR in antiphospholipid antibody-induced renal thrombotic microangiopathy
  4. Platelets and platelet-derived microparticles (PMP) in acute kidney injury and renal allograft rejection
Key publications
  • Jansen MPB, Emal D, Teske GJD, Dessing MC, Florquin S, Roelofs JJTH, Release of extracellular DNA influences renal ischemia reperfusion injury by platelet activation and formation of neutrophil extracellular traps. KIDNEY INT 2017;91 (2):352-364 [PubMed]
  • Lattenist L, Ochodnický P, Ahdi M, Claessen N, Leemans JC, Satchell SC, Florquin S, Gerdes VE, Roelofs JJTH, Renal endothelial protein C receptor expression and shedding during diabetic nephropathy. J THROMB HAEMOST 2016;14 (6):1171-1182 [PubMed]
  • Lattenist L, Kers J, Claessen N, ten Berge IJM, Bemelman FJ, Florquin S, Roelofs JJTH, Renal and urinary levels of endothelial protein C receptor correlate with acute renal allograft rejection. PLOS ONE 2013;8 (5):e64994 [PubMed]
  • Lattenist L, Jansen MPB, Teske G, Claessen N, Meijers JCM, Rezaie AR, Esmon CT, Florquin S, Roelofs JJTH, Activated protein C protects against renal ischaemia/reperfusion injury, independent of its anticoagulant properties. THROMB HAEMOSTASIS 2016;116 (1):124-133 [PubMed]
  • Jansen MPB, Pulskens WP, Butter LM, Florquin S, Juffermans NP, Roelofs JJTH, Leemans JC, MITOCHONDRIAL DNA IS RELEASED IN URINE OF SIRS PATIENTS WITH ACUTE KIDNEY INJURY AND CORRELATES WITH SEVERITY OF RENAL DYSFUNCTION. SHOCK 2018;49 (3):301-310 [PubMed]
All Publications
Curriculum Vitae

Joris Roelofs was educated at the Catholic University of Leuven (Belgium) and the VU University, Amsterdam, where he received his MD degree in 2000. He received his PhD degree from the Faculty of Medicine at the University of Amsterdam in 2007, and he was board certified in Pathology in 2008. Since then, Joris Roelofs has been a Consultant Histopathologist in the Department of Pathology at the AMC, specializing in kidney, liver and lung pathology. In 2010, he worked as a Research Fellow in the Kirkland Center for Lupus Research (Cornell University Medical College, New York City).

Research programmes

Coagulation and the kidney

My group studies reciprocal interactions between coagulation/hemostasis and mechanisms of renal disease. Currently, I focus on 2 distinct but complementary research lines:

1. The role of the Protein C and Protein S anticoagulant systems in acute kidney injury and renal transplant rejection

2. The role of blood platelets in acute and chronic renal disease, with an emphasis on diabetic nephropathy
 

Faculty
Dr. J.J.T.H. Roelofs MD PhD

PhD Students
A.M.L. Scantlebery MSc
M. Uil

Prof. dr. S. Florquin (Renal inflammation and repair)

Other research related activities
  • Contribution to training of professionals, www.renalpathologycourse.org
  • Contribution to training of professionals, Educational Ambassador, International Society of Nephrology
  • Membership of medical or scientific committee, Renal Pathology Society, Research Committee
  • Membership of medical or scientific committee, Stichting PALGA, Wetenschappelijke Raad
  • Membership of medical or scientific committee, ZonMw (Netherlands Organisation for Health Research and Development), Off Road commissie
  • Membership of editorial board / Editorship, ISRN VASCULAR MEDICINE
  • Membership of editorial board / Editorship, World Journal of Nephrology
  • Membership of editorial board / Editorship, World Journal of Translational Medicine