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Dr. L.J.A. Spijkers

Position
Postdoc
Main activities
Research
Specialisation
Sphingolipids in cardiovascular function
Focus of research

Sphingolipids in essential hypertension-associated endothelial dysfunction.

Key publications
  • Spijkers LJA, van den Akker RFP, Janssen BJA, Debets JJ, de Mey JGR, Stroes ESG, van den Born BJH, Wijesinghe DS, Chalfant CE, MacAleese L, Eijkel GB, Heeren RMA, Alewijnse AE, Peters SLM, Hypertension is associated with marked alterations in sphingolipid biology: a potential role for ceramide. PLOS ONE 2011;6 (7):e21817 [PubMed]
  • Spijkers LJA, Janssen BJA, Nelissen J, Meens MJPMT, Wijesinghe D, Chalfant CE, de Mey JGR, Alewijnse AE, Peters SLM, Antihypertensive treatment differentially affects vascular sphingolipid biology in spontaneously hypertensive rats. PLOS ONE 2011;6 (12):e29222 [PubMed]
  • Meens MJPMT, Mattheij NJA, van Loenen PB, Spijkers LJA, Lemkens P, Nelissen J, Compeer MG, Alewijnse AE, de Mey JGR, G-protein beta gamma subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide. BRIT J PHARMACOL 2012;166 (1):297-308 [PubMed]
  • Spijkers LJA, Alewijnse AE, Peters SLM, FTY720 (fingolimod) increases vascular tone and blood pressure in spontaneously hypertensive rats via inhibition of sphingosine kinase. BRIT J PHARMACOL 2012;166 (4):1411-1418 [PubMed]
All Publications
Research programmes

Dr. L. Vogt MD PhD (Renal phenotypes and cardiovascular health)