foto

Dr. M.C. Dessing

Position
Postdoc
Main activities
Research
Specialisation
innate immunity in acute renal failure
Focus of research

Determine the contribution of innate immunity receptors (including Toll-like receptors and TREM) in ischemia-reperfusion induced injury of the kidney.

Curriculum Vitae

Personal details
Title(s), initial(s), first name, surname: Dr. M.C. (Mark) Dessing
Male/female: male
Date and place of birth: 01/04/1976, Gouda
Nationality: Dutch
Birth country of parents: the Netherlands

Master's (‘doctoraal’)
University/College of Higher Education: Biology, University of Utrecht, Utrecht
Date (dd/mm/yy): 31/08/2001
Main subject: Zoology

Doctorate
University/College of Higher Education: Academic Medical Center, University of Amsterdam, Amsterdam
Date (dd/mm/yy): 14/06/2007
Supervisor (‘Promotor’): Prof. Dr. Tom van der Poll
Title of thesis: Toll-like receptors and innate immunity in pneumonia

 Work experience since graduating

  1. 2009–2011 Postdoc position: Department of Pathology, AMC, Amsterdam, the Netherlands (1.0 fte, fixed-term)Project: Contribution of TREM-1 and TREM-2 in acute kidney injury
    Supervision: Prof. Dr. S. Florquin
  2. 2007-2009 Postdoc position: Department of Pathology, AMC, Amsterdam, the Netherlands (1.0 fte, fixed-term)
    Project: Regulation of renal injury, repair and rejection by Toll-like receptors and their negative regulators.
    Supervision: Dr. J.C. Leemans and Prof. Dr. S. Florquin
  3. 2002–2007 PhD student: Center of Experimental and Molecular Medicine, AMC, Amsterdam, the Netherlands (1.0 fte, fixed-term)
    Thesis: Toll-like receptors and innate immunity in pneumonia
    Promotor: Prof. Dr. T. van der Poll
    Co-promotor: Dr. A.F. de Vos
    Date of promotion: June 14, 2007

Brief summary of research over the last five years
As a PhD-student I have investigated Toll-like receptors (TLRs) and innate immunity in pneumonia. TLRs are long known to be involved in inducing an inflammatory response upon recognition of molecules released by, or present on pathogens. During my project I focussed mainly on: (1) recognition of Streptococcus pneumoniae or its ligands by TLRs, CD14 and Myd88 and (2) contribution of TLRs, CD14 during viral pneumonia induced by influenza A. Own research and collaboration with other PhD students at the Center for Experimental Internal Medicine has resulted in several published papers (see List of Publications below). As a Postdoc I have continued my interest in TLRs. More recently TLRs were also shown to be important in recognizing endogenous molecules which can be released upon tissue damage, like in IR induced injury. I have investigated TLR-profiles in biopsies from kidney transplant patients with/without acute rejection. In addition, I investigated the contribution of TLR-ligands HMGB1 and S100A9 and receptor RAGE in experimental renal IR. Research at the department of Pathology has resulted in several papers which are currently submitted or in preparation (4 papers). Due to my grant in 2008 from the Dutch Kidney Foundation I am able to expand my curiosity about the contribution of innate immunity in kidney disease and transplantation. My goal for the near future is to create my own research-niche on TREM signalling in innate to adaptive immunity which will be feasible through this proposal.


International Congress:

  • 2009 2nd European Congress of Immunology (ECI), Berlin, Germany (2 poster presentations)
  • 2008 Toll2008, Lisbon, Portugal (poster presentation)Nantes/Actualités/Transplantation (N.A.T.), Nantes, France (poster presentation)
    American Society of Nephrology (ASN), San Francisco, USA (poster presentation)
  •  2007 TSIS 2007: Trauma, shock, inflammation and sepsis, Munich, Germany
    (poster presentation)
  • 2006 Cytokines 2006, Molecular biology and human diseases, Vienna, Austria
    (oral and poster presentation)
  • 2005 International Cytokine Society Conference 2005, Seoul, South Korea
    (oral and poster presentation).
    Euroconference: at the interface between innate and adaptive immunity in mammalian against bacterial infections, Joachimstal, Germany
    (poster presentation)
  • 2004 Toll2004, Taormina, Italy (2 poster presentations)
  • 2003 International Cytokine Society Annual Conference 2003, Dublin, Ireland
    Toll-like receptors, London, England

International Cooperation
Collaboration with:
• Prof. J.C. Paton, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia
• Prof. S. Knapp, Center for Molecular Medicine, Austrian Academy of Science, Medical University Vienna, Vienna, Austria
• Prof. M. Colonna, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, USA
• Dr. S. Endo, Institute of development, aging and cancer, Dep. Of experimental immunology, Sendai, Japan
• Prof. M. Goldman: Institute for Medical Immunology, Université Libre de Bruxelles, Charleroi, Belgium

Other academic activities

University of Amsterdam, Department of Pathology
I am coordinating editor of the internet site N.I.E.R. (Nephrological Issues in Experimental Research), an educational website dedicated to offer structure and guidance in the world of nephrological research, in particular for young investigators in nephrology (www.NIER.eu).

University of Amsterdam, Center of Experimental and Molecular Medicine (CEMM)
At the department of CEMM I have supervised the work of students, trained new PhD students in the murine-pneumonia model and organized a conference ‘Infectious diseases’ Egmond aan Zee, the Netherlands.

General
I reviewed manuscripts for the international scientific journals: American Journal of Respiratory and Critical Care Medicine, BMC Immunology, Clinical experimental Immunology, International Journal of Biochemistry & Cell Biology, Journal of Infection and The Journal of Infectious Diseases.

Courses/workshops:

  • 2006 Single Nucleotide Polymorphisms (SNP) and human diseases, Rotterdam, the Netherlands
  • 2005 Practical Biostatistics, department of clinical epidemiology and biostatistics, AMC, Amsterdam, the Netherlands
    Advanced Immunology, Amsterdam Leiden institute for immunology, Amsterdam, the Netherlands
    Scientific writing in English for publication, AMC, Amsterdam, the Netherlands
  •  2003 Infectious diseases, research institute of infectious diseases, AMC, Amsterdam, the Netherlands
    Laboratory safety AMC, Amsterdam, the Netherlands
  • 1996 Proefdierkunde artikel 2, (Biotechnician degree) “tweede lid van het dierproevenbesluit”, Utrecht, the Netherlands
    Stralingsfysica onderdeel 5B (Radiation physics degree), Utrecht, the Netherlands

National congress:

  • 2009 NCMLS Symposium 2009, New Frontiers in Pattern Recognition Receptors. Radboud Universitiet, Nijmegen
  • Dutch symposia of Nefrology, Veldhoven
  • 2008 Dutch symposia of Nefrology, Veldhoven
    NfN (Nederlandse federatie voor nefrologie) najaarssymposium, Utrecht (Poster/ oral presentation)
  • 2007 Dutch symposia of Nefrology, Veldhoven
    NfN (Nederlandse federatie voor nefrologie) najaarssymposium, Utrecht
  • 2005 PhD student-retraite Infectious Diseases, Egmond aan Zee
    (oral presentation).
  • 2004 PhD student-retraite Infectious Diseases, Raalte
    (oral presentations)
    Molecular microbiology of infectious diseases, Rotterdam

Membership

  • 2007 - Present Membership of ‘Nederlandse federatie voor Nefrologie’
  • 2006 - Present Membership of ‘GeNeYouS: the Genomics Network for Young Scientists’.

Scholarships and prizes

  • 2008 Grant from Dutch Kidney foundation ‘Open onderzoekprogramma BWO’: Contribution of TREM-1 and TREM-2 in acute kidney injury (C08.2274: 2009-2011, €250.000).
  • 2005 Travel grant from the Spinoza foundation for International Cytokine Society (ICS 2005), Seoul, South Korea
     

List of publications
 

University of Amsterdam, Center of Experimental and Molecular Medicine
1. Dessing MC, Hirst RA, De Vos AF, Van der Poll T. Role of Toll-like receptors 2 and 4 in pulmonary inflammation and injury induced by pneumolysin in mice. In press: Plos One 2010 (IF not applicable)
2. Dessing MC, Van der Sluijs KF, Spek CA, van der Poll T. Gene-expression profiles in murine influenza pneumonia. In press: J Innate Immun 2009;1:366–375 (IF unknown)
3. Wiersinga WJ, Dessing MC, van der Poll T. Gene-expression profiles in murine melioidosis. Microbes Infect. 2008 Jul;10(8):868-77. (IF 2.80)
4. Giebelen IA, Leendertse M, Dessing MC, Meijers JC, Levi M, Draing C, von Aulock S, van der Poll T. Endogenous beta-adrenergic receptors inhibit lipopolysaccharide-induced pulmonary cytokine release and coagulation. Am J Respir Cell Mol Biol. 2008 Sep;39(3):373-9 (IF 4.48)
5. Stegenga ME, van der Crabben SN, Dessing MC, Pater JM, van den Pangaart PS, de Vos AF, Tanck MW, Roos D, Sauerwein HP, van der Poll T. Effect of acute hyperglycaemia and/or hyperinsulinaemia on proinflammatory gene expression, cytokine production and neutrophil function in humans. Diabet Med. 2008 Feb;25(2):157-64. (IF 3.17)
6. Dessing MC, Schouten M, Draing C, Levi M, von Aulock S, van der Poll T. Role played by Toll-like receptors 2 and 4 in lipoteichoic acid-induced lung inflammation and coagulation. J Infect Dis. 2008 Jan 15;197(2):245-52. (IF 5.68)
7. Wolthuis EK, Choi G, Dessing MC, Bresser P, Lutter R, Dzoljic M, van der Poll T, Vroom MB, Hollmann M, Schultz MJ. Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury. Anesthesiology. 2008 Jan;108(1):46-54 (IF 5.12)
8. Dessing MC, Florquin S, Paton JC, van der Poll T. Toll-like receptor 2 contributes to antibacterial defence against pneumolysin-deficient pneumococci. Cell Microbiol. 2008 Jan;10(1):237-46. (IF 5.60)
9. Dessing MC, van der Sluijs KF, Florquin S, van der Poll T. Monocyte chemoattractant protein 1 contributes to an adequate immune response in influenza pneumonia Clin Immunol. 2007 Dec;125(3):328-36 (IF 3.61)
10. Dessing MC, van der Sluijs KF, Florquin S, van der Poll T. CD14 plays a limited role during influenza A virus infection in vivo. Immunol Lett. 2007 Oct 31;113(1):47-51 (IF 2.86)
11. Wiersinga WJ, Wieland CW, Dessing MC, Chantratita N, Cheng AC, Limmathurotsakul D, Chierakul W, Leendertse M, Florquin S, de Vos AF, White N, Dondorp AM, Day NP, Peacock SJ, van der Poll T. Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis). PLoS Med. 2007 Jul 31;4(7):e248. (IF 13.18)
12. Wiersinga WJ, Dessing MC, Kager PA, Cheng AC, Limmathurotsakul D, Day NP, Dondorp AM, van der Poll T, Peacock SJ. High-throughput mRNA profiling characterizes the expression of inflammatory molecules in sepsis caused by Burkholderia pseudomallei. Infect Immun. 2007 Jun;75(6):3074-9.
(IF 3.99)
13. Dessing MC, Knapp S, Florquin S, de Vos AF, van der Poll T. CD14 facilitates invasive respiratory tract infection by Streptococcus pneumoniae. Am J Respir Crit Care Med. 2007 Mar 15;175(6):604-11. (IF 9.79)
14. Dessing MC, van der Sluijs KF, Florquin S, Akira S, van der Poll T. Toll-like receptor 2 does not contribute to host response during postinfluenza pneumococcal pneumonia. Am J Respir Cell Mol Biol. 2007 May;36(5):609-14. (IF 4.48)
15. van Zoelen MA, Bakhtiari K, Dessing MC, van't Veer C, Spek CA, Tanck M, Meijers JC, van der Poll T. Ethyl pyruvate exerts combined anti-inflammatory and anticoagulant effects on human monocytic cells. Thromb Haemost. 2006 Dec;96(6):789-93. (IF 3.80)
16. Dessing MC, de Vos AF, Florquin S, van der Poll T. Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia. Infect Immun. 2006 Dec;74(12):7021-3. (IF 3.99)
17. Maris NA, Dessing MC*, de Vos AF, Bresser P, van der Zee JS, Jansen HM, Spek CA, van der Poll T. Toll-like receptor mRNA levels in alveolar macrophages after inhalation of endotoxin. Eur Respir J. 2006 Sep;28(3):622-6. * Equal contribution. (IF 5.55)
18. Maris NA, de Vos AF, Dessing MC, Spek CA, Lutter R, Jansen HM, van der Zee JS, Bresser P, van der Poll T. Antiinflammatory effects of salmeterol after inhalation of lipopolysaccharide by healthy volunteers. Am J Respir Crit Care Med. 2005 Oct 1;172(7):878-84 (IF 9.79)

University of Utrecht, Department of Pharmacology and Pathophysiology
1. De Vries A, Engels F, Henricks PA, Leusink-Muis T, McGregor GP, Braun A, Groneberg DA, Dessing MC, Nijkamp FP, Fischer A. Airway hyper-responsiveness in allergic asthma in guinea-pigs is mediated by nerve growth factor via the induction of substance P: a potential role for trkA. Clin Exp Allergy. 2006 Sep;36(9):1192-200 (IF 3.56)
2. De Vries A, Dessing MC, Engels F, Henricks PA, Nijkamp FP: Nerve growth factor induces a neurokinin-1 receptor- mediated airway hyperresponsiveness in guinea pigs. Am J Respir Crit Care Med. 1999 May;159(5 Pt 1):1541-4 (IF 9.79)

Books, or contributions to books

2007 Thesis University of Amsterdam: M.C. Dessing: Toll-like receptors and innate immunity in pneumonia. ISBN: 978-90-9021864-9.
 

Research programmes

Prof. dr. S. Florquin (Renal inflammation and repair)

Dr. J.C. Leemans (Renal Inflammation and Repair)