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Dr. N.A. Kootstra

Position
Associate professor (UHD)
Main activities
Research
Specialisation
Immunology; Virology; infectious disease
Focus of research

Host-virus interactions in the natural course of infection and during therapeutic interventions.

Key publications
  • Cobos Jiménez V, Wit FWNM, Joerink M, Maurer I, Harskamp AM, Schouten J, Prins M, van Leeuwen EMM, Booiman T, Deeks SG, Reiss P, Kootstra NA [Contributors: Reiss P, Wit FWNM, van der Valk M, Schouten J , Kooij KW, van Zoest RA, Elsenga BC, Prins M, Martens M, Moll S, Berkel J, Totté M, Visser GR, Kovalev S, Zaheri S, Hillebregt MMJ, Ruijs YMC, Benschop DP, Reis P, Janssen FR, Heidenrijk M, Zikkenheiner W, Boumans L, Kootstra NA, Harskamp-Holwerda AM, Maurer I, Mangas Ruiz MM, Girigorie AF, Boeser-Nunnink B, Geerlings SE, Godfried MH, Goorhuis A, Hovius JWR, Nellen FJB, van der Meer JTM, van der Poll T, Prins JM, Wiersinga WJ, van Eden J, van Hes AMH, Mutschelknauss M, Nobel HE, Pijnappel FJJ, Westerman AM, de Jong J, Postema PG, Bisschop PHLT, Serlie MJM, Lips P, Dekker E, de Rooij SEJA, Willemsen JMR, Vogt L, Portegies P, Schmand BA, Geurtsen GJ , ter Stege JA, Klein Twennaar M, van Eck-Smit BLF, de Jong M, Richel DJ, Verbraak FD, Demirkaya N , Visser I, Ruhé HG, Nieuwkerk PT, van Steenwijk RP, Dijkers E, Majoie CBLM, Caan MWA, Su T, van Lunsen HW, Nievaard MAF, van den Born BJH, Stroes ESG, Mulder WMC]] , T-Cell Activation Independently Associates With Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment. J INFECT DIS 2016;214 (2):216-225 [PubMed]
  • van der Ree MH, de Vree JM, Stelma F, Willemse S, van der Valk M, Rietdijk S, Molenkamp R, Schinkel J, van Nuenen AC, Beuers U, Hadi S, Harbers M, van der Veer E, Liu K, Grundy J, Patick AK, Pavlicek A, Blem J, Huang M, Grint P, Neben S, Gibson NW, Kootstra NA, Reesink HW, Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial. LANCET 2017;389 (10070):709-717 [PubMed]
  • Booiman T, Setiawan LC, Kootstra NA, Genetic variation in Trex1 affects HIV-1 disease progression. AIDS 2014;28 (17):2517-2521 [PubMed]
  • Jansen L, de Niet A, Stelma F, van Iperen EPA, van Dort KA, Tempelmans Plat-Sinnige MJ, Takkenberg RB, Chin DJ, Zwinderman AHK, Lopatin U, Kootstra NA, Reesink HW, HBsAg loss in patients treated with peginterferon alfa-2a and adefovir is associated with SLC16A9 gene variation and lower plasma carnitine levels. J HEPATOL 2014;61 (4):730-737 [PubMed]
  • Gijsbers EF, van Nuenen AC, de la Peňa AT, Bowles EJ, Stewart-Jones GB, Schuitemaker H, Kootstra NA, Low level of HIV-1 evolution after transmission from mother to child. SCI REP-UK 2014;4:5079 [PubMed]
All Publications
Research programmes

Host-virus interaction and immune responses in viral infections.

mainly focuses on virus-host interactions in the natural course of HIV-1 infection and during therapeutic intervention. In particular, we study the role of restriction factors and other newly identified HIV dependency factors in HIV-1 replication and pathogenesis. Furthermore, we study immunological ageing in patients with HIV receiving long-term cART who participate in the prospective ageing cohort study on “Co-morbidity and Ageing with HIV” (AGEhIV) and participate in the COBRA study (EU FP7) on “Co-morbidity in relation to Aids”.

In collaboration with Sanquin and the Department of Gastroenterology at the AMC, the role of viral and host factors in HBV replication and the response to antiviral therapy in chronic hepatitis B patients is investigated.

Our group participates in the Amsterdam Cohort Studies on HIV infection and AIDS (www.amsterdamcohortstudies.org) and the prospective HIV and aging cohort (AgeIV).

Faculty
Dr. N.A. Kootstra

Postdocs
Dr. T. Booiman PhD

PhD Students
Drs. R. Erken MD
Drs. Z. Kruize
V. Loukachov
L. van Pul

Others
Ing. B.D.M. Boeser-Nunnink
Ing. K.A. van Dort
Ing. A.F. Girigorie
Ing. A.M. Harskamp-Holwerda
Ing. M. Mangas-Ruiz
Ing. I. Maurer
Ing. A.C. van Nuenen

Prof. dr. P. Reiss MD PhD (Complications of HIV and HIV treatment)

Other research related activities
  • Membership of medical or scientific committee, Amsterdam Cohort Studies, Steering Committee/Scientific Board
  • Membership of medical or scientific committee, AgeIV study, Steering Committee/Scientific Board
  • Membership of medical or scientific committee, COBRA, Steering Committee/Scientific Board
  • Outside member, Subcommittee Medical/Veterinarian issues of the Committee Genetic Modification (COGEM)
Current research funding
  • AMC
  • Nederlandse Vereniging voor Gastro-Enterologie
  • Stichting Aidsfonds/SOA AIDS Nederland
  • Stichting AMC Foundation (Vrijgesteld)
  • Toegepaste en Technische Wetenschappen (TTW)