Dr. R.A. Bem MD PhD

Main activities
Patient care, Research
Focus of research

1) The acute respiratory distress syndrome (ARDS).
2) Acute lung injury in animals.
3) Severe pneumovirus (e.g. RSV) lung disease in humans and animals. 

In these fields, specific research topics include:
- cellular mechanisms of lung epithelial injury (e.g. pro-apoptotic pathways)
- pro-inflammatory responses (e.g. neutrophil activation)
- children, effect of age
- effect of mechanical ventilation
- cardiovascular and fluid effects

Studies under progress are translational projects including experiments with human patient material (ex vivo and in vitro) and animal research.

Key publications
  • Bem RA, Domachowske JB, Rosenberg HF, Animal models of human respiratory syncytial virus disease. AM J PHYSIOL-LUNG C 2011;301 (2):L148-L156 [PubMed]
  • Cortjens B, de Boer OJ, de Jong R, Antonis AF, Sabogal Piñeros YS, Lutter R, van Woensel JB, Bem RA, Neutrophil extracellular traps cause airway obstruction during respiratory syncytial virus disease. J PATHOL 2016;238 (3):401-411 [PubMed]
  • Bem RA, van Woensel JBM, Lutter R, Domachowske JB, Medema JP, Rosenberg HF, Bos AP, Granzyme A- and B-Cluster Deficiency Delays Acute Lung Injury in Pneumovirus-Infected Mice. J IMMUNOL 2010;184 (2):931-938 [PubMed]
  • Bem RA, Bos AP, Wösten-van Asperen RM, Bruijn M, Lutter R, Sprick MR, van Woensel JBM, Potential Role of Soluble TRAIL in Epithelial Injury in Children with Severe RSV Infection. AM J RESP CELL MOL 2010;42 (6):697-705 [PubMed]
  • Bem RA, van Woensel JBM, Bos AP, Koski A, Farnand AW, Domachowske JB, Rosenberg HF, Martin TR, Matute-Bello G, Mechanical ventilation enhances lung inflammation and caspase activity in a model of mouse pneumovirus infection. AM J PHYSIOL-LUNG C 2009;296 (1):L46-L56 [PubMed]
All Publications
Research programmes

J.B.M. van Woensel MD PhD (Acute lung injury in children)