Dr. S. Mastenbroek PhD

Scientific staff member (UD)
Main activities
Patient care, Research
Clinical Embryologist
Focus of research

Dr. Sebastiaan Mastenbroek is an Assistant Professor and one of the Clinical Embryologists of the Center for Reproductive Medicine of the Academic Medical Center.

An important focus of his research in past years has been Preimplantation Genetic Screening (PGS) and human preimplantation embryology. PGS is a technique to select embryos in an IVF treatment based on their chromosomal content. In 2007, publication of his randomized controlled trial on PGS in the New England Journal of Medicine started a fiercely debated controversy on the use of PGS as it showed that the technique lowered pregnancy rates after IVF instead of increasing the pregnancy rates. He then published research that provided technical as well as biological reasons for the inefficacy of PGS.

In a broader perspective he is interested in ovarian aging, early human development, implantation, assisted reproductive techniques and evidence based laboratory practice. He is supervising multiple randomized controlled trials in IVF, involved in the development of techniques that are able to analyse single oocytes and embryos, and uses these techniques to find biological plausibility for the clinical outcomes of his trials.

He is a board member of the SAF foundation (, chair of the LSFD laboratory working group, board member of the special interest group ART of the Dutch Society of Obstetrics and Gynaecology, associate editor of Human Reproduction Online, editor of the Cochrane Gynaecology and Fertility Group, and member of the Science Committee of the Dutch Society for Clinical Embryology. 



Key publications
  • Mastenbroek S, Twisk M, van Echten-Arends J, Sikkema-Raddatz B, Korevaar JC, Verhoeve HR, Vogel NEA, Arts EGJM, de Vries JWA, Bossuyt PM, Buys CHCM, Heineman MJ, Repping S, van der Veen F, In vitro fertilization with preimplantation genetic screening. NEW ENGL J MED 2007;357 (1):9-17 [PubMed]
  • Mastenbroek S, Twisk M, van der Veen F, Repping S, Preimplantation genetic screening: a systematic review and meta-analysis of RCTs. HUM REPROD UPDATE 2011;17 (4):454-466 [PubMed]
  • Kleijkers SHM, Mantikou E, Slappendel E, Consten D, van Echten-Arends J, Wetzels AM, van Wely M, Smits LJM, van Montfoort APA, Repping S, Dumoulin JCM, Mastenbroek S, Influence of embryo culture medium (G5 and HTF) on pregnancy and perinatal outcome after IVF: a multicenter RCT. HUM REPROD 2016;31 (10):2219-2230 [PubMed]
  • Mantikou E, Youssef MAFM, van Wely M, van der Veen F, Al-Inany HG, Repping S, Mastenbroek S, Embryo culture media and IVF/ICSI success rates: a systematic review. HUM REPROD UPDATE 2013;19 (3):210-220 [PubMed]
  • Mantikou E, Jonker MJ, Wong KM, van Montfoort APA, de Jong M, Breit TM, Repping S, Mastenbroek S, Factors affecting the gene expression of in vitro cultured human preimplantation embryos. HUM REPROD 2016;31 (2):298-311 [PubMed]
All Publications
Research programmes

Reproduction & Development - Human Reproduction - Clinical Embryology

  Our research focusses on clinical and basic aspects of Human Reproductive Biology.

Dr. S. Mastenbroek PhD

PhD Students
Drs. R.P. Berkhout MD
M.A.J. Smits
M. Tarahomi MD
M.S. Zagers MSc

Prof. dr. S. Repping (Reproduction & Development -- Human Reproduction)

Prof. dr. F. van der Veen (Reproduction and development])

Other research related activities
  • Board of directors / Trustees / Supervisory board, Stichting Automatisering Fertiliteit (SAF)
  • Board of directors / Trustees / Supervisory board, Working group lab ´Landelijk Specialistisch Fertiliteits Dossier´
  • Board of directors / Trustees / Supervisory board, Dutch Society for Obstetrics and Gynaecology - SIG ART
  • Membership of editorial board / Editorship, COCHRANE DATABASE OF SYSTEMATIC REVIEWS
  • Membership of medical or scientific committee, Society for Clinical Embryology, Scientific Committee