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Dr. S.I. Gringhuis PhD

Position
Other
Main activities
Research
Specialisation
Molecular biology, signal transduction, innate immunology
Focus of research

My research focuses on the identification of signaling pathways induced by C-type lectins on dendritic cells and how these signaling pathways lead to pathogen-specific T cell polarization, neutrophil activation as well as anti-viral responses, which could be targeted therapeutically to either enhance immunity or deter aberrant immunity.
 

Key publications
  • Gringhuis SI, Kaptein TM, Wevers BA, Theelen B, van der Vlist M, Boekhout T, Geijtenbeek TBH, Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1 beta via a noncanonical caspase-8 inflammasome. NAT IMMUNOL 2012;13 (3):246-U63 [PubMed]
  • Geijtenbeek TBH, Gringhuis SI, C-type lectin receptors in the control of T helper cell differentiation. NAT REV IMMUNOL 2016;16 (7):433-448 [PubMed]
  • Wevers BA, Kaptein TM, Zijlstra-Willems EM, Theelen B, Boekhout T, Geijtenbeek TBH, Gringhuis SI, Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antifungal immunity. CELL HOST MICROBE 2014;15 (4):494-505 [PubMed]
  • Mesman AW, Zijlstra-Willems EM, Kaptein TM, de Swart RL, Davis ME, Ludlow M, Duprex WP, Gack MU, Gringhuis SI, Geijtenbeek TBH, Measles Virus Suppresses RIG-I-like Receptor Activation in Dendritic Cells via DC-SIGN-Mediated Inhibition of PP1 Phosphatases. CELL HOST MICROBE 2014;16 (1):31-42 [PubMed]
  • Gringhuis SI, Hertoghs N, Kaptein TM, Zijlstra-Willems EM, Sarrami-Fooroshani R, Sprokholt JK, van Teijlingen NH, Kootstra NA, Booiman T, van Dort KA, Ribeiro CMS, Drewniak A, Geijtenbeek TBH, HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3. NAT IMMUNOL 2017;18 (2):225-235 [PubMed]
All Publications
Research programmes

C-type lectin signaling in infection and immunity

Dendritic cells initiate adaptive immune responses to combat infections. C-type lectins are crucial in pathogen recognition and in shaping adaptive immunity. However, little is known about the molecular signaling pathways that are induced by C-type lectins upon pathogen binding. My research focuses on the identification of signaling pathways induced by C-type lectins and how these signaling pathways lead to pathogen-specific T cell polarization. Furthermore, we investigate whether these signaling pathways are involved in the induction of aberrant immune responses as observed during asthma or allergy.

Faculty
Dr. S.I. Gringhuis PhD

PhD Students
L.C. Helgers
B.M. Nijmeijer MSc
M. Stunnenberg

Others
Ing. T.M. Kaptein MSc

Prof. dr. T.B.H. Geijtenbeek (Dendritic cells in infection and immunity)

Current research funding
  • Stichting Aidsfonds/SOA AIDS Nederland