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Drs. B.A. Wevers MSc

Position
PhD student
Main activities
Research
Specialisation
Molecular biology, signal transduction, innate immunology
Focus of research

Antifungal immunity. Opportunistic fungi represent a serious health problem by causing systemic life-threatening infections in individuals who are immune compromised, including HIV-1/AIDS and cancer patients. Effective phagocytic clearance of fungal pathogens requires intact Th-17 and Th1 immune responses, for mobilization and activation of neutrophils, respectively. Recognition of fungal cell wall carbohydrates by C-type lectins on human dendritic cells and subsequent cytokine production is crucial for the orchestration of protective T helper cell polarization. We are identifying C-type lectins that interact with different fungal species and how these C-type lectins induce adaptive immunity. In particular we are investigating signaling by C-type lectins such as dectin-1 and dectin-2.

Key publications
  • Gringhuis SI, Wevers BA, Kaptein TM, van Capel TMM, Theelen B, Boekhout T, de Jong EC, Geijtenbeek TBH, Selective C-Rel Activation via Malt1 Controls Anti-Fungal T-H-17 Immunity by Dectin-1 and Dectin-2. PLOS PATHOG 2011;7 (1):e1001259 [PubMed]
  • Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SCM, Geijtenbeek TBH, Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk. NAT IMMUNOL 2009;10 (2):203-213 [PubMed]
All Publications