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F. Eftimov MD PhD

Positions
Other Academic Staff, Medical Specialist
Main activities
Patient care, Research
Specialisation
Neurologist, Neuromuscular disorders
Focus of research

 The Department of Neurology performs clinical and translational research within three research themes: infection & inflammation, cerebrovascular disorders, and movement disorders. The themes are imbedded in the nine translational research programs of Amsterdam Neuroscience, the research institute of neuroscience investigators in the Amsterdam area. All staff members of the Department of Neurology are involved in research and collaborate within Neuroscience Amsterdam, with other academic and non-academic hospitals, and with international research groups.
Infection & Inflammation
We perform clinical translational research in the field of neurological infections & inflammation. We perform prospective clinical cohort studies, randomized clinical trials, and experimental research, combining our clinical expertise with groundbreaking, translational approaches using clinical data, human samples, next generation sequencing, in vitro techniques, and mouse models in the era's of bacterial meningitis & encephalitis, infections after stroke, septic encephalopathy, and inflammatory diseases of peripheral nerves and muscles.
Since the completion of my Neurology training in 2012 I have been working as a neurologist, with a special interest in neuromuscular diseases and neuroimmunology. In daily practice, I see patients with all kinds of neuromuscular disease, such as motor neuron disease, myopathies, and neuropathies. My specific area of interest is chronic inflammatory demyelinating polyneuropathy (CIDP). Other areas of expertise include myositis, neurological manifestations of sarcoidosis and various inflammatory neuropathies (GBS, MMN, vasculitis). As one of GBS/CIDP Foundation centers of excellence, we seek to improve treatment in CIDP and other inflammatory neuropathies. In 2015 I finished my PhD thesis ‘Treatment of chronic inflammatory neuropathies’. Currently I am combining a translational approach to search for biomarkers of disease activity in CIDP and clinical research that focuses on long-term outcome of the disease. I am the coordinating investigator of a multicenter randomised controlled trial (IOC trial) to study overtreatment with IVIg in CIDP. In recent years I have initiated several CIDP studies and have participated in international randomised controlled trials in CIDP. As one of the initiators of the International CIDP Outcome Study (ICOS) and co-organizer of the European Neuromuscular Center workshop on international standardization of CIDP registries I hope to improve international collaboration and to contribute to discovering new treatments for this rare disease.

Key publications
  • Eftimov Filip, van Schaik Ivo Chronic inflammatory demyelinating polyradiculoneuropathy: update on clinical features, phenotypes and treatment options Current opinion in neurology 2013;26 (5):496-502 [PubMed]
  • Eftimov Filip, Winer John B., Vermeulen Marinus, de Haan Rob, van Schaik Ivo N. Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy Cochrane database of systematic reviews (Online) 2013;2013 (12):CD001797 [PubMed]
  • Eftimov F., Vermeulen M., van Doorn P. A., Brusse E., van Schaik I. N., van den Berg L. H., van der Pol W. L., Faber C. G., Oostrom J. C. H., Vogels O. J. M., Kleine B. U., van Norden A. G. W., Verschuuren J. J. G. M., Hadden R. D. M. Long-term remission of CIDP after pulsed dexamethasone or short-term prednisolone treatment Neurology 2012;78 (14):1079-1084 [PubMed]
  • van Schaik Ivo N., Eftimov Filip, van Doorn Pieter A., Brusse Esther, van den Berg Leonard H., van der Pol W. Ludo, Faber Catharina G., van Oostrom Joost Ch, Vogels Oscar Jm, Hadden Rob Dm, Kleine Bert U., van Norden Anouk Gw, Verschuuren Jan Jgm, Dijkgraaf Marcel Gw, Vermeulen Marinus Pulsed high-dose dexamethasone versus standard prednisolone treatment for chronic inflammatory demyelinating polyradiculoneuropathy (PREDICT study): a double-blind, randomised, controlled trial Lancet neurology 2010;9 (3):245-253 [PubMed]
  • Eftimov Filip, Vermeulen Marinus, de Haan Rob J., van den Berg Leonard H., van Schaik Ivo N. Subcutaneous immunoglobulin therapy for multifocal motor neuropathy Journal of the peripheral nervous system 2009;14 (2):93-100 [PubMed]
All Publications
Research programmes

Prof. I.N. van Schaik PhD (Neuroinfection & inflammation)

Prof. D. van de Beek MD PhD (Neuroinfection and Inflammation)

Current research funding
  • Biogen Limited
  • GBS/CIDP Foundation International
  • Grifols S.A.
  • Medical Research BV
  • Peripheral Nerve Society
  • Prinses Beatrix Spierfonds
  • ProPhase, LLC.
  • UCB Biopharma SPRL
  • ZonMw