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PhD H.P. Kok

Position
Research Associate
Main activities
Research
Specialisation
Hyperthermia
Focus of research

Petra Kok is responsible for developing the clinical hyperthermia treatment planning at Amsterdam UMC. Her research on hyperthermia has resulted in a research line focusing on clinical hyperthermia treatment planning using on-line adaptive strategies. Furthermore, she explores biological modelling to predict the hyperthermic radiosensitization in terms of effective enhanced radiation dose. Her multidisciplinary research also aims to improve the quality of hyperthermia treatment planning by including patient-specific dielectric tissue properties reconstructed using MR techniques and using advanced thermal modelling techniques including discrete vasculature. Aim of this effort is gaining optimal treatment quality and synergy with radiotherapy and chemotherapy both in terms of tumor temperatures achieved, as well as optimal clinical sequence and time interval with other modalities.

The impact of her research is enhanced by ongoing translation of the developed planning modules into a commercially available clinical hyperthermia treatment planning package for use by clinical hyperthermia professionals worldwide.

Ongoing granted research projects:

  • UVA 2017-10873: Clinical evaluation of the benefit of planning based steering to improve effectiveness of hyperthermia in cervical cancer patients. Project leaders H.P. Kok, J. Crezee, L.J.A. Stalpers. Funding €326.486,-; 1 Postdoc.
  • UVA 2017-10595: Development of treatment planning to optimize clinical effectiveness of hyperthermic intraperitoneal chemotherapy in colorectal cancer patients. Project leaders J. Crezee, N.A.P. Franken, H.P. Kok, P.J. Tanis. Funding € 563.765,-; 2 PhD students

Previous granted research projects:

  • UVA 2012-5540: Towards biological treatment planning in radiotherapy combined with hyperthermia to improve clinical outcome. Project leaders H.P. Kok, N.A.P. Franken, L.J.A. Stalpers. € 553.300,-; 2 PhD students
  • UVA 2012-5393: Active hot spot suppression to improve thermal dose and clinical outcome of locoregional hyperthermia treatment. Project leaders J. Crezee, H.P. Kok, L.J.A. Stalpers.
    € 339.300,-; 1 Postdoc.

Petra Kok has been co-promotor of three PhD students:

  • G. Schooneveldt (UvA, 22 October 2019),
  • C.M. van Leeuwen (UvA, 3 July 2018),
  • A.L. Oei (UvA, 24 March 2017).

Current supervision of PhD students:

  • D.R. Löke (UvA, expected 2021),
  • Two PhD students (vacancies) in the framework of H2020-MSCA-ITN-2020-955625 “HYPERBOOST” (UvA, expected 2024).

Selected other activities:

  • Invited lectures at several conferences and other meetings: MyWave 2020, Lisbon; EuCAP 2020, Copenhagen; PIERS 2019, Rome; STM 2019, St. Pete Beach; Kantonsspital Aarau 2019; San Giovanni Hospital- Oncologic Institute Bellinzona 2017; ESHO 2014, Turin.
  • 2020: Invited guest editor for special issue "Hyperthermia in Cancer" in ‘Cancers’ (impact factor 6.162).
  • Host prof Peter Wust (Berlin), Spinoza chair at University of Amsterdam 3-4 July 2018
  • Regular visits as guest researcher at Chalmers University, Göteborg, Sep 2013 – May 2017.
  • Discussion leader/ opponent during PhD licentiate thesis defense of P. Takook (Gothenburg; 2016 May 18, Towards a microwave hyperthermia system for head and neck tumors)
Key publications
  • Kok H. P., Schooneveldt G., Bakker A., de Kroon-Oldenhof R., Korshuize-van Straten L., de Jong C. E., Steggerda-Carvalho E., Geijsen E. D., Stalpers L. J. A., Crezee J. Predictive value of simulated SAR and temperature for changes in measured temperature after phase-amplitude steering during locoregional hyperthermia treatments International journal of hyperthermia 2018;35 (1):330-339 [PubMed]
  • van Leeuwen C. M., Crezee J., Oei A. L., Franken N. A. P., Stalpers L. J. A., Bel A., Kok H. P. The effect of time interval between radiotherapy and hyperthermia on planned equivalent radiation dose International journal of hyperthermia 2018;34 (7):901-909 [PubMed]
  • van Leeuwen C. M., Crezee J., Oei A. L., Franken N. A. P., Stalpers L. J. A., Bel A., Kok H. P. 3D radiobiological evaluation of combined radiotherapy and hyperthermia treatments International journal of hyperthermia 2017;33 (2):160-169 [PubMed]
  • Kok H. Petra, Korshuize-van Straten Linda, Bakker Akke, de Kroon-Oldenhof Rianne, Geijsen Elisabeth D., Stalpers Lukas J. A., Crezee Johannes Online Adaptive Hyperthermia Treatment Planning During Locoregional Heating to Suppress Treatment-Limiting Hot Spots International journal of radiation oncology, biology, physics 2017;99 (4):1039-1047 [PubMed]
  • van Leeuwen Caspar M., Oei Arlene L., Chin Kenneth W. T. K., Crezee Johannes, Bel Arjan, Westermann Anneke M., Buist Marrije R., Franken Nicolaas A. P., Stalpers Lukas J. A., Kok H. Petra A short time interval between radiotherapy and hyperthermia reduces in-field recurrence and mortality in women with advanced cervical cancer Radiation oncology (London, England) 2017;12 (1):75 [PubMed]
All Publications
Curriculum Vitae

2007-present: Postdoc researcher on development and application of hyperthermia treatment planning.

2007: PhD thesis 'Treatment planning for locoregional and intraluminal hyperthermia' (University of Amsterdam).

2002-2007: PhD student on a KWF project to develop a new dual modality hyperthermia technique for treatment of cancer at the oesophagus and other intracavitary locations.

2002: M. Sc. Thesis in Computational Science (Utrecht University). Graduation project on adaptive moving mesh methods for reaction-diffusion models from chemistry and biology.

  Projects:
• Project leader of KWF-supported research project UVA 2012-5540: "Towards biological treatment planning in radiotherapy combined with hyperthermia to improve clinical outcome".
  Project leaders: Dr. H.P. Kok, Dr. N.A.P. Franken, Dr. L.J.A. Stalpers.

• Co-project leader of KWF-supported research project UVA 2012-5393: "Active hot spot suppression to improve thermal dose and clinical outcome of locoregional hyperthermia treatment".
  Project leaders: Dr. J. Crezee, Dr. H.P. Kok, Dr. L.J.A. Stalpers.

 Awards:
2012: ESHO Rosner Award (11th ICHO meeting, Kyoto, Japan).
2012: Poster Presentation Award (11th ICHO meeting, Kyoto, Japan).
2009: ESHO Student Award (25th ESHO meeting, Verona, Italy).
2007: Editor's Award from the International Journal of Hyperthermia
           (editorial award best paper 2006)
2005: Kim Young Investigator Award (22nd ESHO meeting, Graz, Austria).
2004: Young Investigator Travel Award (9th ICHO meeting, St. Louis, USA).

 

Research programmes

PhD J. Crezee (Hyperthermia)

Prof. PhD C.R.N. Rasch (Image guided and physics application in the clinic)

Current research funding
  • KWF Kankerbestrijding