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PhD J.H.T.M. Koelman

Position
Medical Specialist
Main activities
Patient care
Specialisation
Neurology
Focus of research

The Department of Neurology performs clinical and translational research within three research themes: infection & inflammation, cerebrovascular disorders, and movement disorders. .The themes are imbedded in the nine translational research programs of Amsterdam Neuroscience, the research institute of neuroscience investigators in the Amsterdam area. All staff members of the Department of Neurology are involved in research and collaborate within Neuroscience Amsterdam, with other academic and non-academic hospitals, and with international research groups.

The research of the movement disorders group focuses on improving treatment, diagnosis, and insight in pathophysiology of movement disorders such as Parkinson’s disease, tremor, myoclonus, and dystonia. The group has a strong clinical research infrastructure to conduct large cohort studies and randomized controlled trials on interventions ranging from medication to botulinum toxin injections and Deep Brain Stimulation (DBS), aimed at solving burning clinical questions. Advanced neurophysiological measures and analysis techniques, intraoperative microrecording from nuclei situated deeply in the brain, and (functional) MRI are available to answer important diagnostic and pathophysiological research questions. The group is embedded in the neurodegeneration program of Amsterdam Neuroscience.

The research I work on, focuses on clinical neurophysiological aspects of movement disorders and on treatment with botulinum toxin, especially in patients with dystonia and functional movement disorders.  In addition I am involved in research projects on clinical neurophysiological aspects of schizophrenia and on prognostification of outcome after cardiac arrest.

 

 

Key publications
  • van der Salm Sandra M. A., Koelman Johannes H. T. M., Henneke Samantha, van Rootselaar Anne-Fleur, Tijssen Marina A. J. Axial jerks: a clinical spectrum ranging from propriospinal to psychogenic myoclonus Journal of neurology 2010;257 (8):1349-1355 [PubMed]
  • Bouwes Aline, Binnekade Jan M., Kuiper Michael A., Bosch Frank H., Zandstra Durk F., Toornvliet Arnoud C., Biemond Hazra S., Kors Bas M., Koelman Johannes H. T. M., Verbeek Marcel M., Weinstein Henry C., Hijdra Albert, Horn Janneke Prognosis of coma after therapeutic hypothermia: A prospective cohort study Annals of neurology 2012;71 (2):206-212 [PubMed]
  • Tricht Mirjam J. van, Nieman Dorien H., Koelman Johannes H. T. M., van der Meer Johan N., Bour Lo J., de Haan Lieuwe, Linszen Don H. Reduced Parietal P300 Amplitude is Associated with an Increased Risk for a First Psychotic Episode Biological psychiatry 2010;68 (7):642-648 [PubMed]
  • Nijmeijer S. W. R., Koelman J. H. T. M., Standaar T. S. M., Postma M., Tijssen M. A. J. Cervical dystonia: improved treatment response to botulinum toxin after referral to a tertiary centre and the use of polymyography Parkinsonism & related disorders 2013;19 (5):533-538 [PubMed]
  • Verhamme Camiel, van Schaik Ivo N., Koelman Johannes H. T. M., de Haan Rob J., de Visser Marianne The natural history of Charcot-Marie-Tooth type 1A in adults: a 5-year follow-up study Brain 2009;132 (Part 12):3252-3262 [PubMed]
All Publications