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PhD J.M. Dijk

Position
Medical Specialist
Main activities
Patient care, Research
Specialisation
Neurology, movement disorders
Focus of research

The Department of Neurology performs clinical and translational research within three research themes: infection & inflammation, cerebrovasculair disorders, and movement disorders.The themes are imbedded in the nine translational research programs of Amsterdam Neuroscience, the research institute of neuroscience investigators in the Amsterdam area. All staff members of the Department of Neurology are involved in research and collaborate within Neuroscience Amsterdam, with other academic and non-academic hospitals, and with international research groups.


The research of the movement disorders group focuses on improving treatment, diagnosis, and insight in pathophysiology of movement disorders such as Parkinson’s disease, tremor, myoclonus, and dystonia. The group has a strong clinical research infrastructure to conduct large cohort studies and randomized controlled trials on interventions ranging from medication to botulinum toxin injections and Deep Brain Stimulation (DBS), aimed at solving burning clinical questions. Advanced neurophysiological measures and analysis techniques, intraoperative microrecording from nuclei situated deeply in the brain, and (functional) MRI are available to answer important diagnostic and pathophysiological research questions. The group is embedded in the neurodegeneration program of Amsterdam Neuroscience.


The focus of my current research is improving the treatment of patients with movement disorders. Several clinical trials are currently being carried out in which the effects of DBS and Continuous Intrajejunal Levodopa Infusion for advanced Parkinson’s disease are compared, the effect of treatment with botulinum toxin on functional myoclonus is being evaluated and in which the role of serotonergic system in cervical dystonia is being assessed.


My PhD-thesis focussed on another topic: new vascular risk factors. Several studies, mainly concerning the vessel wall characteristics arterial stiffness and intima-media-thickness, were carried out in the Secondary Manifestations of ARTerial disease (SMART) cohort in the Julius Center for Health Sciences and Primary Care (UMCU Utrecht).

 

Key publications
  • Dijk Joke M., Tijssen Marina A. J. Management of patients with myoclonus: available therapies and the need for an evidence-based approach Lancet neurology 2010;9 (10):1028-1036 [PubMed]
  • van Tricht Mirjam J., Dreissen Yasmine E. M., Cath Danielle, Dijk Joke M., Contarino Maria Fiorella, van der Salm Sandra M., Foncke Elisabeth M. J., Groen Justus L., Schmand Ben, Tijssen Marina A. J. Cognition and psychopathology in myoclonus-dystonia Journal of neurology, neurosurgery, and psychiatry 2012;83 (8):814-820 [PubMed]
  • Zoons E., Dijkgraaf M. G. W., Dijk J. M., van Schaik I. N., Tijssen M. A. Botulinum toxin as treatment for focal dystonia: a systematic review of the pharmaco-therapeutic and pharmaco-economic value Journal of neurology 2012;259 (12):2519-2526 [PubMed]
  • Zoons E., Booij J., Nederveen A. J., Dijk J. M., Tijssen M. A. J. Structural, functional and molecular imaging of the brain in primary focal dystonia-A review NeuroImage 2011;56 (3):1011-1020 [PubMed]
  • Dijk Joke M., Algra Ale, van der Graaf Yolanda, Grobbee Diederick E., Bots Michiel L. Carotid stiffness and the risk of new vascular events in patients with manifest cardiovascular disease. The SMART study European heart journal 2005;26 (12):1213-1220 [PubMed]
All Publications
Current research funding
  • Crediteurenadm. VUmc, p/a Profource Service Center
  • ZonMw