M.A. Middelkamp Hup MD PhD

Other Academic Staff, Medical Specialist
Main activities
Education, Patient care, Research
Dermatology; focus on Pediatric Dermatology, Atopic Dermatitis and Allergic Contact Dermatitis
Focus of research

Atopic Dermatitis (AD)


-AD in children: fillagrin mutations, skin barrier biomarkers and immunological biomarkers, related to clinical parameters and phenotype


-The role of allergic contact dermatitis in children with and without AD


-Fillagrin mutations and clinical outcome of AD


-Immunology: T cells subsets, with emphasis on IL-31 producing T cells; Cytokine profiles in transdermal fluid




- treatment of ulcerated hemangiomas




Key publications
  • Szegedi Krisztina, Kremer Andreas E., Kezic Sanja, Teunissen Marcel B. M., Bos Jan D., Luiten Rosalie M., Res Pieter C., Middelkamp-Hup Maritza A. Increased frequencies of IL-31-producing T cells are found in chronic atopic dermatitis skin Experimental dermatology 2012;21 (6):431-436 [PubMed]
  • Proudfoot L. E., Powell A. M., Ayis S., Barbarot S., Baselga Torres E., Deleuran M., Fölster-Holst R., Gelmetti C., Hernández-Martin A., Middelkamp-Hup M. A., Oranje A. P., Logan K., Perkins M., Patrizi A., Rovatti G., Schofield O., Spuls P., Svensson A., Vestergaard C., Wahlgren C.-F., Schmitt J., Flohr C. The European treatment of severe atopic eczema in children taskforce (TREAT) survey British journal of dermatology 2013;169 (4):901-909 [PubMed]
  • Szegedi K., Lutter R., Res P. C., Bos J. D., Luiten R. M., Kezic S., Middelkamp-Hup M. A. Cytokine profiles in interstitial fluid from chronic atopic dermatitis skin Journal of the European Academy of Dermatology and Venereology 2015;29 (11):2136-2144 [PubMed]
  • Roekevisch E., Leeflang M. M. G., Schram M. E., Campbell L. E., Irwin McLean W. H., Kezic S., Bos J. D., Spuls P. I., Middelkamp-Hup M. A. Patients with atopic dermatitis with filaggrin loss-of-function mutations show good but lower responses to immunosuppressive treatment British journal of dermatology 2017;177 (6):1745-1746 [PubMed]
  • Lubbes Stefanie, Rustemeyer Thomas, Sillevis Smitt Johannes H., Schuttelaar Marie Louise, Middelkamp-Hup Maritza A. Contact sensitization in Dutch children and adolescents with and without atopic dermatitis - a retrospective analysis Contact dermatitis 2017;76 (3):151-159 [PubMed]
All Publications
Research programmes

Prof. R.M. Luiten PhD (Pigment cell disorders of the skin)

Prof. P.I. Spuls PhD (dermato-immunology and dermato-epidemiology)


M.A. Middelkamp Hup MD PhD (Promoties)

(Medewerkers buiten research programmes van afdeling Dermatologie)