MD PhD J.H. van der Lee

Research Associate
Main activities
clinical epidemiology
Focus of research
  1. Systematic Reviews
  2. Clinimetrics
  3. RCT methodology related to optimal sample sizes
Key publications
  • van der Lee Johanna H., Wesseling Judit, Tanck Michael W., Offringa Martin Sequential design with boundaries approach in pediatric intervention research reduces sample size Journal of clinical epidemiology 2010;63 (1):19-27 [PubMed]
  • Fernandes Ricardo M., van der Lee Johanna H., Offringa Martin A systematic review of the reporting of Data Monitoring Committees roles, interim analysis and early termination in pediatric clinical trials BMC pediatrics 2009;9 (1):77 [PubMed]
  • van der Lee Johanna H., Tanck Michael W. T., Wesseling Judit, Offringa Martin Pitfalls in the design and analysis of paediatric clinical trials: a case of a 'failed' multi-centre study, and potential solutions Acta paediatrica (Oslo, Norway 2009;98 (2):385-391 [PubMed]
  • van der Lee J. H., Wesseling J., Tanck M. W. T., Offringa M. Efficient ways exist to obtain the optimal sample size in clinical trials in rare diseases Journal of clinical epidemiology 2008;61 (4):324-330 [PubMed]
  • van der Lee Johanna H., Mokkink Lidwine B., Grootenhuis Martha A., Heymans Hugo S., Offringa Martin Definitions and measurement of chronic health conditions in childhood: a systematic review JAMA 2007;297 (24):2741-2751 [PubMed]
All Publications
Curriculum Vitae

After graduation from medical school (Erasmus University Rotterdam, 1987), Hanneke van der Lee (1963) worked as an epidemiological researcher in general practice and in paediatrics (hemoglobinopathies and other congenital anomalies). Her PhD study “forced use of the upper extremity in chronic stroke patients” (2001) was performed at the department of rehabilitation medicine of the VU medical centre in Amsterdam.

Hanneke has worked as an epidemiologist at the Department of Pediatric Clinical Epidemiology in the Emma Children’s Hospital AMC Amsterdam since 2003. Her main interests are systematic reviews, clinimetrics, and RCT methodology related to optimal sample sizes. Since July 2009 she has been the convener of the international Standard Development Groups on Data Monitoring Committees and Adequate Sample Sizes (

Research programmes

MD PhD J.H. van der Lee (Promoties)

Prof. PhD M. Offringa (Innovative methodologies for child health clinical trials)

MD PhD J.W. Groothoff (End-stage Renal Insufficiency in Children)