P. Henneman PhD

Research Associate
Main activities
Education, Research
Epigenetic Epidemiology, Genetic Epidemiology
Focus of research

Situated at the Clinical Genetics department of the Amsterdam Medical Center (NL), Dr Henneman (PI) is leading a research group studying epigenetics of complex and non-complex diseases in order to detect novel associated genetic and epigenetic loci. Moreover, Dr. Henneman is closely involved in follow-up translational studies of novel detected loci. Three major topics are in particular Dr. Henneman’s interest: (1) Early developmental  environmental factors and their epigenetic contribution to complex diseases e.g. food allergy, Type II diabetes mellitus and stress disorders like post-traumatic stress disorder (PTSD). (2) Epigenetics in intervention and translational studies focusing on e.g. PTSD and Crohn’s disease. (3) Clinical diagnostic applications of epigenetic signatures in rare syndromes. In relation to the latter, Dr. Henneman is affiliated to the dept. of clinical genetics, genome diagnostics, where he is closely involved in the implementation and application of DNA-methylation signatures of rare syndromes under the flag of EpiSign, an international collaboration with Canadian (London Health Sciences Centre, Canada, Episign, Dr. Bekim Sadokovic) and USA partners. In total Dr. Henneman’ s research group involves 9 PhD students, 2 bioinformaticians and 1 Post doc researcher. In 2017 his first PhD student defended her thesis on complex traits and epigenetic analyses within a large cohort of Ghanaian migrants (promotor Prof. dr. Charles Agyemang). In 2018 Dr. Henneman received substantial funding (in collaboration with Prof. dr, G.R.A.M. D’Haens) from the Helmsley charity foundation (USA) to study therapeutic response of anti-inflammatory therapy in patients suffering from Crohn’s disease in order to develop a personalized treatment protocol. Within this project, Dr. Henneman’ s group also applied single cell technology in this cohort in order to study the context and origin of the detected differential DNA-methylation profiles (unpublished).

Key publications
  • van der Laan Loes C., Meeks Karlijn A. C., Chilunga Felix P., Agyemang Charles, Venema Andrea, Mannens Marcel M. A. M., Zafarmand Mohammad H., Klipstein-Grobusch Kerstin, Smeeth Liam, Adeyemo Adebowale, Henneman Peter Epigenome-wide association study for perceived discrimination among sub-Saharan African migrants in Europe - the RODAM study Scientific reports 2020;10 (1) [PubMed]
  • Jansen Philip R., Petrus Nicole C. M., Venema Andrea, Posthuma Danielle, Mannens Marcel M. A. M., Sprikkelman Aline B., Henneman Peter Higher Polygenetic Predisposition for Asthma in Cow's Milk Allergic Children Nutrients 2018;10 (11) [PubMed]
  • Henneman Peter, Bouman Arjan, Mul Adri, Knegt Lia, van der Kevie-Kersemaekers Anne-Marie, Zwaveling-Soonawala Nitash, Meijers-Heijboer Hanne E. J., Paul van Trotsenburg A. S., Mannens Marcel M. Widespread domain-like perturbations of DNA methylation in whole blood of Down syndrome neonates PLoS ONE 2018;13 (3) [PubMed]
  • Henneman Peter, Petrus Nicole C. M., Venema Andrea, van Sinderen Femke, van der Lip Karin, Hennekam Raoul C., Mannens Marcel, Sprikkelman Aline B. Genetic susceptibility for cow's milk allergy in Dutch children: the start of the allergic march? Clinical and translational allergy 2016;6:7 [PubMed]
  • Li Yim Andrew Y. F., Duijvis Nicolette W., Zhao Jing, de Jonge Wouter J., D'Haens Geert R. A. M., Mannens Marcel M. A. M., Mul Adri N. P. M., te Velde Anje A., Henneman Peter Peripheral blood methylation profiling of female Crohn's disease patients Clinical epigenetics 2016;8:65 [PubMed]
All Publications
Research programmes

Prof. M.M.A.M. Mannens PhD (Genome diagnostics i.p. epigenetics of disease)