foto

PhD A. Baartscheer

Position
Support Staff
Main activities
Research
Specialisation
Ionic metabolism in normal and failing hearts, electrophysiology, fatty acid metabolism, cholesterol
Focus of research

Ionic (especially caclium and sodium) metabolism and its role in excitation contraction coupling in the setting of heart failure.

Prevention of the develoment of heart failure by controlling the ionic metabolism.

Activation of the down regulated fatty acid metabolism in HF.

The role of cholestrol metabolism on arrhythmogenesis.

 

Key publications
  • Baartscheer A., Schumacher C. A., van Borren M. M. G. J., Belterman C. N. W., Coronel R., Fiolet J. W. T. Increased Na+/H+-exchange activity is the cause of increased [Na+](i) and underlies disturbed calcium handling in the rabbit pressure and volume overload heart failure model Cardiovascular research 2003;57 (4):1015-1024 [PubMed]
  • Baartscheer Antonius, Schumacher Cees A., Belterman Charly N. W., Coronel Ruben, Fiolet Jan W. T. SR calcium handling and calcium after-transients in a rabbit model of heart failure Cardiovascular research 2003;58 (1):99-108 [PubMed]
  • Baartscheer A., Schumacher C. A., Belterman C. N. W., Coronel R., Fiolet J. W. T. [Na+](i) and the driving force of the Na+/Ca2+-exchanger in heart failure Cardiovascular research 2003;57 (4):986-995 [PubMed]
  • Baartscheer Antonius, Schumacher Cees A., van Borren Marcel M. G. J., Belterman Charly N. W., Coronel Ruben, Opthof Tobias, Fiolet Jan W. T. Chronic inhibition of Na+/H+-exchanger attenuates cardiac hypertrophy and prevents cellular remodeling in heart failure Cardiovascular research 2005;65 (1):83-92 [PubMed]
  • Baartscheer A., Hardziyenka M., Schumacher C. A., Belterman C. N. W., van Borren M. M. G. J., Verkerk A. O., Coronel R., Fiolet J. W. T. Chronic inhibition of the Na(+)/H(+)- exchanger causes regression of hypertrophy, heart failure, and ionic and electrophysiological remodelling British journal of pharmacology 2008;154 (6):1266-1275 [PubMed]
All Publications
Research programmes

MD PhD R. Coronel (Mechanisms of sudden cardiac death)