A.J.M. Tijsen PhD

Research Associate
Main activities
Molecular Cardiology
Focus of research

- Allelic imbalance as explanation for differences in disease severity in inherited arrhythmias

- Inhibition of alleles with dominant-negative mutations as therapy in inherited arrhythmias and heart failure

I study these two aspects in iPS-derived cardiomyocytes

Key publications
  • Tijsen Anke J., Creemers Esther E., Moerland Perry D., de Windt Leon J., van der Wal Allard C., Kok Wouter E., Pinto Yigal M. MiR423-5p As a Circulating Biomarker for Heart Failure Circulation research 2010;106 (6):1035-U63 [PubMed]
  • Tijsen Anke J., van der Made Ingeborg, van den Hoogenhof Maarten M., Wijnen Wino J., van Deel Elza D., de Groot Nina E., Alekseev Sergey, Fluiter Kees, Schroen Blanche, Goumans Marie-José, van der Velden Jolanda, Duncker Dirk J., Pinto Yigal M., Creemers Esther E. The microRNA-15 family inhibits the TGFβ-pathway in the heart Cardiovascular research 2014;104 (1):61-71 [PubMed]
  • Amin Ahmad S., Giudicessi John R., Tijsen Anke J., Spanjaart Anne M., Reckman Yolan J., Klemens Christine A., Tanck Michael W., Kapplinger Jamie D., Hofman Nynke, Sinner Moritz F., Müller Martina, Wijnen Wino J., Tan Hanno L., Bezzina Connie R., Creemers Esther E., Wilde Arthur A. M., Ackerman Michael J., Pinto Yigal M. Variants in the 3 untranslated region of the KCNQ1-encoded K(v)7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner European heart journal 2012;33 (6):714-723 [PubMed]
  • Shinnawi Rami, Huber Irit, Maizels Leonid, Shaheen Naim, Gepstein Amira, Arbel Gil, Tijsen Anke J., Gepstein Lior Monitoring Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Genetically Encoded Calcium and Voltage Fluorescent Reporters Stem cell reports 2015;5 (4):582-596 [PubMed]
  • Duisters Rudy F., Tijsen Anke J., Schroen Blanche, Leenders Joost J., Lentink Viola, van der Made Ingeborg, Herias Veronica, van Leeuwen Rick E., Schellings Mark W., Barenbrug Paul, Maessen Jos G., Heymans Stephane, Pinto Yigal M., Creemers Esther E. miR-133 and miR-30 Regulate Connective Tissue Growth Factor Implications for a Role of MicroRNAs in Myocardial Matrix Remodeling Circulation research 2009;104 (2):170-U61 [PubMed]
All Publications
Research programmes

Prof. Y. Pinto PhD (Molecular genetics of heart failure)